                        SEQUENCE LISTING

<110> CODEXIS, INC.
 
<120> ENGINEERED URIDINE PHOSPHORYLASE VARIANT ENZYMES
 
<130> CX2-214WO2
 
<140> 
<141> 2021-12-17
 
<150> US 63/127,431
<151> 2020-12-18

<150> US 63/148,324
<151> 2021-02-11
 
<160> 1200
 
<210> 1
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 2
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 2
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 3
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 3
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 4
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 4
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 5
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 5
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaaag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 6
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 6
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Lys 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 7
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 7
atgtccaagt ctgatagttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 8
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 8
Met Ser Lys Ser Asp Ser Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 9
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 9
atgtccaagt ctgatgggtt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 10
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 10
Met Ser Lys Ser Asp Gly Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 11
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 11
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaggt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 12
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 12
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Gly 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 13
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 13
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 14
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 14
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 15
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 15
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 16
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 16
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 17
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 17
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 18
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 18
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 19
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 19
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttctc gggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 20
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 20
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Arg Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 21
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 21
atgtccaagt ctgatgttac gcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 22
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 22
Met Ser Lys Ser Asp Val Thr His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 23
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 23
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatagt 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 24
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 24
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Ser Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 25
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 25
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gcgtccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 26
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 26
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Arg Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 27
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 27
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatgac 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 28
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 28
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asp Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 29
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 29
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaact gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 30
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 30
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 31
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 31
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaggcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 32
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 32
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 33
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 33
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaagt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 34
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 34
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ser 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 35
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 35
atgtccaagt ctgatcggtt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 36
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 36
Met Ser Lys Ser Asp Arg Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 37
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 37
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataac 120
ccggttttcc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtcagac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 38
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 38
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Phe Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 39
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 39
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatagt 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaact gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaagcagac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 40
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 40
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Ser Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 41
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 41
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatagt 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 42
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 42
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Ser Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 43
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 43
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaact 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 44
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 44
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Thr 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 45
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 45
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataac 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtactga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtcagac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 46
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 46
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Leu Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 47
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 47
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatg 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 48
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 48
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Met 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 49
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 49
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaact gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 50
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 50
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 51
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 51
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaggcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 52
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 52
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 53
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 53
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg cgccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 54
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 54
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Ala Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 55
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 55
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtcagac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggtgcgt cgtctgctg                        759

 
<210> 56
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 56
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Val Arg Arg Leu Leu             
                245                 250             

 
<210> 57
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 57
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaaat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaggcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 58
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 58
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 59
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 59
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaagtgac gactgcgctg 420
gttgaagctg cgaaagaact gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 60
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 60
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Val Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 61
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 61
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttttcc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaagcagac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 62
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 62
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Phe Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 63
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 63
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatagt 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaggcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 64
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 64
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Ser Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 65
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 65
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 66
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 66
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 67
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 67
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatgac 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 68
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 68
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asp Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 69
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 69
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataac 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtcagac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 70
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 70
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 71
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 71
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gaagccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 72
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 72
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Lys Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 73
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 73
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaaat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaggcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 74
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 74
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 75
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 75
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgggta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 76
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 76
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Gly Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 77
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 77
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcac gattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 78
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 78
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Thr Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 79
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 79
atgtccaagt ctgattattt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 80
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 80
Met Ser Lys Ser Asp Tyr Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 81
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 81
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 82
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 82
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 83
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 83
atgtccaagt ctgattggtt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 84
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 84
Met Ser Lys Ser Asp Trp Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 85
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 85
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtactga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtcagac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 86
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 86
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Leu Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 87
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 87
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtactga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaagcagac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 88
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 88
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Leu Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 89
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 89
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 90
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 90
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 91
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 91
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaagcagac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 92
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 92
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 93
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 93
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatagt 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 94
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 94
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Ser Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 95
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 95
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtactga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 96
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 96
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Leu Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 97
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 97
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatagt 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaagtgac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaggcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 98
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 98
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Ser Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Val Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 99
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 99
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataac 120
ccggttttcc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaggcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 100
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 100
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Phe Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 101
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 101
atgtccaagt ctgatgtttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 102
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 102
Met Ser Lys Ser Asp Val Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 103
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 103
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaagtgac gactgcgctg 420
gttgaagctg cgaaagaact gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 104
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 104
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Val Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 105
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 105
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaact gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 106
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 106
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 107
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 107
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gctggatagt 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaggcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 108
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 108
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Leu Asp Ser Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 109
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 109
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gctggataag 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaact gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 110
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 110
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Leu Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 111
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 111
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat attgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 112
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 112
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ile Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 113
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 113
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gctggatgac 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaact gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaagcagac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 114
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 114
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Leu Asp Asp Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 115
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 115
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatagt 120
ccggttttcc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaggcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 116
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 116
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Ser Pro Val Phe Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 117
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 117
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaaat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaagcagac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 118
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 118
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 119
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 119
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 120
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 120
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 121
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 121
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 122
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 122
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 123
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 123
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatgac 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtactga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaggcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 124
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 124
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asp Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Met Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Leu Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 125
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 125
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat tgggagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 126
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 126
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Trp Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 127
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 127
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctag gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 128
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 128
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Arg Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 129
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 129
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatct gttgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 130
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 130
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Cys 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 131
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 131
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaaat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtcagac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 132
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 132
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 133
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 133
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 134
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 134
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 135
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 135
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctat gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 136
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 136
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Met Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 137
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 137
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt acggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 138
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 138
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 139
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 139
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccgattaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 140
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 140
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Ile Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 141
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 141
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttctt ctgaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 142
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 142
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Ser Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 143
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 143
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatagt 120
ccggttttcc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 144
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 144
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Ser Pro Val Phe Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 145
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 145
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 146
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 146
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 147
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 147
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatgac 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtcagac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 148
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 148
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asp Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 149
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 149
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtgtgggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 150
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 150
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Val Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 151
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 151
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 152
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 152
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 153
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 153
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttttcc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaagcagac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 154
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 154
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Phe Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 155
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 155
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattgggg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggtgcgt cgtctgctg                        759

 
<210> 156
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 156
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Val Arg Arg Leu Leu             
                245                 250             

 
<210> 157
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 157
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 158
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 158
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 159
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 159
atgtccaagt ctgatttttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 160
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 160
Met Ser Lys Ser Asp Phe Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 161
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 161
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatagt 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 162
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 162
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Ser Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 163
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 163
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataac 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaagcagac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 164
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 164
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 165
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 165
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaagcgcat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 166
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 166
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ala His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 167
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 167
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga ggctccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 168
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 168
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ala Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 169
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 169
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 170
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 170
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 171
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 171
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatgac 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtcagac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 172
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 172
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asp Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 173
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 173
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat ccggagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 174
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 174
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Pro Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 175
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 175
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttttcc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaact gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 176
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 176
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Phe Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 177
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 177
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttgct acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 178
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 178
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Ala Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 179
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 179
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataac 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaaat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 180
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 180
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 181
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 181
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttttcc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 182
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 182
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Phe Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 183
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 183
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatgac 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 184
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 184
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asp Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 185
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 185
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat tatgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 186
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 186
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Tyr Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 187
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 187
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggtttgt acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 188
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 188
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Cys Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 189
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 189
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatagt 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaggcaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 190
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 190
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Ser Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 191
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 191
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaaagtat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtcagac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 192
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 192
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 193
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 193
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaggcaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 194
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 194
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 195
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 195
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gctggatagt 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaact gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 196
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 196
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Leu Asp Ser Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 197
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 197
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaaagcat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 198
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 198
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Lys His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 199
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 199
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggatagt 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaaat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtgcaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 200
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 200
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Ser Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Ala Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 201
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 201
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gggtccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 202
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 202
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Gly Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 203
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 203
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaata ctggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 204
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 204
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Thr Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 205
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 205
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaggcaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 206
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 206
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 207
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 207
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgaggt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 208
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 208
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Glu Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 209
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 209
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataac 120
ccggttttcc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaact gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 210
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 210
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Phe Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 211
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 211
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataac 120
ccggttttcc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaaat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 212
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 212
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Phe Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 213
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 213
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccgtctcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 214
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 214
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ser Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 215
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 215
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcagtgtgga agcggcgcgt cgtctgctg                        759

 
<210> 216
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 216
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Ser Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 217
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 217
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcgtga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 218
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 218
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Arg Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 219
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 219
atgtccaagt ctgatgtttt tcatctcggc ctcactaaag ctgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaaac tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaaat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 220
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 220
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Ala Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 221
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 221
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgatggatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 222
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 222
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Met Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 223
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 223
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaagcagac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 224
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 224
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 225
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 225
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat acggagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 226
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 226
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Thr Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 227
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 227
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagtcta tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 228
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 228
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 229
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 229
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaaggcat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 230
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 230
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Arg His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 231
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 231
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattgagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 232
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 232
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Glu Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 233
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 233
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacatc gtcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 234
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 234
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ser Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 235
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 235
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggtttcg acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 236
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 236
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Ser Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 237
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 237
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcgttcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 238
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 238
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Val Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 239
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 239
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagag tcgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 240
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 240
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Ser Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 241
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 241
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttttcc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagaaat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaagcagac cgaaagccgt 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 242
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 242
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Phe Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Glu Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 243
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 243
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaagag 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattagtg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 244
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 244
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Glu 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Ser Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 245
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 245
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 246
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 246
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 247
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 247
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 248
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 248
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 249
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 249
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 250
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 250
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 251
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 251
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 252
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 252
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 253
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 253
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 254
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 254
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 255
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 255
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 256
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 256
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 257
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 257
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggt 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 258
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 258
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 259
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 259
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 260
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 260
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 261
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 261
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 262
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 262
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 263
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 263
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 264
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 264
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 265
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 265
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 266
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 266
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 267
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 267
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 268
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 268
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 269
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 269
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 270
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 270
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 271
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 271
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac ccctagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 272
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 272
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Pro Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 273
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 273
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggctgagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 274
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 274
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Ala Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 275
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 275
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 276
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 276
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 277
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 277
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 278
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 278
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 279
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 279
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagtcga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 280
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 280
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 281
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 281
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cgtggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 282
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 282
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Val Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 283
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 283
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 284
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 284
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 285
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 285
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 286
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 286
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 287
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 287
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 288
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 288
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 289
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 289
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 290
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 290
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 291
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 291
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc ggttgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 292
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 292
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Val Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 293
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 293
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 294
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 294
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 295
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 295
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 296
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 296
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 297
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 297
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 298
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 298
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 299
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 299
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 300
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 300
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 301
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 301
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 302
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 302
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 303
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 303
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 304
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 304
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 305
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 305
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 306
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 306
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 307
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 307
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 308
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 308
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 309
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 309
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 310
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 310
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 311
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 311
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 312
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 312
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 313
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 313
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 314
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 314
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 315
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 315
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggt 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 316
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 316
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 317
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 317
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 318
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 318
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 319
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 319
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caagtggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 320
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 320
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 321
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 321
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cgcggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 322
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 322
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Ala Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 323
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 323
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 324
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 324
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 325
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 325
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 326
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 326
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 327
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 327
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 328
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 328
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 329
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 329
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 330
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 330
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 331
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 331
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc aaggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 332
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 332
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Lys Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 333
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 333
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 334
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 334
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 335
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 335
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagcggg 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 336
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 336
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser Gly 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 337
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 337
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 338
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 338
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 339
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 339
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattca caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttcttgt 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 340
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 340
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile His Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Cys 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 341
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 341
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatgggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 342
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 342
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Met Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 343
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 343
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagggga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 344
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 344
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Gly Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 345
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 345
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 346
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 346
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 347
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 347
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
ttggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 348
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 348
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Leu Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 349
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 349
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgaggt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 350
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 350
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Glu Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 351
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 351
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggag 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 352
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 352
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 353
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 353
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgtcgcaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 354
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 354
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Ser Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 355
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 355
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg ggcggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 356
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 356
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Ala Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 357
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 357
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg tttgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 358
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 358
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Phe Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 359
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 359
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 360
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 360
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 361
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 361
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 362
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 362
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 363
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 363
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 364
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 364
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 365
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 365
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 366
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 366
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 367
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 367
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gccggacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 368
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 368
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Arg Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 369
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 369
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaagtga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 370
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 370
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Val Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 371
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 371
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac ctcgagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 372
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 372
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Ser Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 373
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 373
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagaata tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 374
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 374
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Asn Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 375
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 375
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
gcgattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 376
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 376
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro Ala Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 377
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 377
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 378
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 378
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 379
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 379
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca agtcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 380
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 380
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Ser His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 381
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 381
atgtccaagt ctgatgtttt ccatctgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaagcagt agaaagccgc 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 382
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 382
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Val Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 383
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 383
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggat 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 384
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 384
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Asp His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 385
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 385
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actttggttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 386
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 386
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr Leu Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 387
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 387
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 388
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 388
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 389
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 389
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 390
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 390
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 391
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 391
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
acgattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 392
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 392
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro Thr Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 393
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 393
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagacg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 394
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 394
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Thr His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 395
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 395
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcttatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 396
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 396
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Leu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 397
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 397
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc cgtgcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 398
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 398
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Arg Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 399
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 399
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg cgggtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 400
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 400
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Arg Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 401
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 401
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaagga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 402
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 402
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Arg Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 403
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 403
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacctac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 404
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 404
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Pro Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 405
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 405
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctgg tggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 406
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 406
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Gly Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 407
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 407
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtaag gcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 408
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 408
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Arg Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 409
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 409
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc ggctgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 410
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 410
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Ala Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 411
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 411
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 412
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 412
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 413
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 413
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatca tgcctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 414
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 414
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Met Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 415
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 415
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 416
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 416
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 417
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 417
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
ggggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 418
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 418
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Gly Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 419
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 419
atgtccgagt ctgatgtttt ccatctgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttact acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacagac tgaaagccac 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 420
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 420
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 421
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 421
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttctactgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 422
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 422
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Thr Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 423
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 423
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tgtgggagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 424
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 424
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Trp Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 425
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 425
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gtggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 426
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 426
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Val Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 427
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 427
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cggtagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 428
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 428
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Gly Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 429
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 429
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
tggattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 430
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 430
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro Trp Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 431
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 431
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 432
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 432
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 433
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 433
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tgagggagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 434
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 434
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Arg Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 435
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 435
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 436
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 436
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 437
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 437
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
ctgctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 438
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 438
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Leu Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 439
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 439
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gactccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 440
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 440
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Thr Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 441
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 441
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcacagca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 442
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 442
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Gln His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 443
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 443
atgtccgagt ctgatgtttt ccatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 444
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 444
Met Ser Glu Ser Asp Val Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 445
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 445
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaagcagt agaaagccgc 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 446
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 446
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Val Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 447
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 447
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagagg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 448
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 448
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Arg His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 449
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 449
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 450
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 450
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 451
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 451
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
gtgattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 452
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 452
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro Val Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 453
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 453
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 454
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 454
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 455
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 455
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggtggagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 456
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 456
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Val Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 457
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 457
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tgggtgagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 458
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 458
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Gly Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 459
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 459
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 460
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 460
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 461
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 461
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 462
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 462
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 463
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 463
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaaacgac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 464
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 464
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Thr Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 465
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 465
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 466
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 466
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 467
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 467
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
ccggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 468
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 468
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Pro Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 469
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 469
atgtccgagt ctgatgtttt ccatctgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgagta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttact acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaagcaac tgaaagccgc 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 470
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 470
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser Arg 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 471
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 471
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaggt agaaagccac 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 472
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 472
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 473
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 473
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttctgcggat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 474
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 474
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ala Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 475
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 475
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcggatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 476
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 476
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 477
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 477
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 478
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 478
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 479
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 479
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gttgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 480
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 480
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Val Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 481
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 481
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccct gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat atcgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 482
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 482
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Leu Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ile Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 483
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 483
atgtccgagt ctgatgtttt ccatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgagta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtcaggt agaaagccac 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 484
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 484
Met Ser Glu Ser Asp Val Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 485
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 485
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tgcatgagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 486
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 486
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met His Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 487
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 487
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt catggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 488
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 488
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Met Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 489
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 489
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
aagggttctc gcgaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gcggagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 490
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 490
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Arg Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 491
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 491
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 492
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 492
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 493
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 493
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcatcaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 494
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 494
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met His Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 495
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 495
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tgcaggagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 496
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 496
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Gln Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 497
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 497
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggctc gattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 498
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 498
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ser Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 499
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 499
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 500
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 500
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 501
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 501
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 502
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 502
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 503
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 503
atgtccgagt ctgatgtttt ccatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgagta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaagcaac tgaaagccac 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 504
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 504
Met Ser Glu Ser Asp Val Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 505
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 505
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tgtgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtattggta caacgggcgc gattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat tgggagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 506
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 506
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Trp Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 507
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 507
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tgaaggagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 508
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 508
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Lys Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 509
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 509
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 510
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 510
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 511
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 511
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattgtgccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 512
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 512
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Val Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 513
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 513
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaatcgac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 514
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 514
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ser Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 515
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 515
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtgg tactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 516
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 516
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Gly Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 517
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 517
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttgga tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 518
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 518
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Trp Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 519
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 519
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttctgcgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 520
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 520
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Leu Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 521
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 521
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc acttggtggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 522
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 522
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Trp Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 523
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 523
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaagctac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 524
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 524
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 525
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 525
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgaggcga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 526
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 526
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ala Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 527
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 527
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 528
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 528
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 529
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 529
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatgg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 530
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 530
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Met Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 531
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 531
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 532
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 532
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 533
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 533
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tgtctgagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 534
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 534
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Ser Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 535
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 535
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattctgccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 536
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 536
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Leu Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 537
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 537
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 538
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 538
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 539
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 539
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaattga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 540
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 540
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Leu Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 541
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 541
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
tgggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 542
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 542
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Trp Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 543
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 543
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttaccgtg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 544
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 544
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Arg Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 545
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 545
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gttggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 546
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 546
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Leu Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 547
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 547
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gcatccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 548
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 548
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu His Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 549
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 549
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc agcctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 550
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 550
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Gln Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 551
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 551
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca acttcggttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 552
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 552
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr Ser Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 553
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 553
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgtcggatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 554
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 554
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Ser Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 555
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 555
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaata tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 556
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 556
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Asn Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 557
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 557
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actttgtggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 558
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 558
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Leu Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 559
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 559
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcaggtc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 560
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 560
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gly Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 561
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 561
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaggcgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 562
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 562
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Arg Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 563
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 563
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga aactgcgcgt cgtctgctg                        759

 
<210> 564
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 564
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Thr Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 565
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 565
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 566
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 566
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 567
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 567
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgagta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgcgtcaggt agaaagccac 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 568
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 568
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Arg Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 569
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 569
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtacta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 570
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 570
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Thr Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 571
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 571
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actgttgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 572
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 572
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr Val Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 573
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 573
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattaggccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 574
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 574
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Arg Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 575
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 575
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgcg acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 576
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 576
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Ala Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 577
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 577
atgtccaagt ctgatgtttt tcatctcggc ctcactttga acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 578
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 578
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Leu Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 579
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 579
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat ggtgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 580
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 580
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Gly Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 581
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 581
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tgtgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
aagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga ggcgccgaat atcgagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 582
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 582
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ala Pro Asn Ile Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 583
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 583
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat tgggagacga tgaaacaaac cgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 584
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 584
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Trp Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 585
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 585
atgtccaagt ctgatgtttt ccatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgagta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaagcagt agaaagccac 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 586
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 586
Met Ser Lys Ser Asp Val Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Ala Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 587
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 587
atgtccgagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt accgaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaagt ggaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 588
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 588
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Thr Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 589
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 589
atgtccaagt ctgatgtttt ccatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgagta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaggt agaaagccac 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 590
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 590
Met Ser Lys Ser Asp Val Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 591
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 591
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtagaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac tgaaagccat 720
gcggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 592
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 592
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 593
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 593
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 594
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 594
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 595
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 595
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggcggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 596
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 596
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Ala Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 597
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 597
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggaggagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 598
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 598
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 599
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 599
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgac 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 600
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 600
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 601
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 601
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagcca 300
catattaatg tgggtgatgt cgtggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 602
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 602
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Val Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 603
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 603
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggcggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggggttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 604
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 604
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Ala Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 605
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 605
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgac 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggcggagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggggttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 606
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 606
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Ala Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 607
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 607
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 608
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 608
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 609
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 609
atgtccgaat ctgatgtttt tcatcttggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggggttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 610
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 610
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 611
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 611
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 612
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 612
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 613
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 613
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaggagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggggttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 614
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 614
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 615
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 615
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 616
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 616
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 617
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 617
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggcggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggggttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 618
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 618
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Ala Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 619
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 619
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggaggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggggttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 620
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 620
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 621
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 621
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cgtggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 622
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 622
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Val Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 623
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 623
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cgtggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgac 480
accttctacc caggccagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggaggagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggggttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 624
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 624
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Val Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 625
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 625
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgac 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggggttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 626
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 626
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 627
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 627
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 628
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 628
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 629
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 629
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cgtggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggcggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggggttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 630
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 630
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Val Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Ala Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 631
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 631
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggaggagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 632
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 632
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 633
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 633
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggaggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 634
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 634
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 635
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 635
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggggttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 636
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 636
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 637
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 637
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggcggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 638
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 638
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Ala Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 639
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 639
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 640
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 640
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 641
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 641
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cgtggttacc aaggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 642
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 642
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Val Val Thr Lys Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 643
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 643
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cgtggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagacga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 644
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 644
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Val Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 645
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 645
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 646
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 646
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 647
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 647
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 648
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 648
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 649
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 649
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 650
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 650
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 651
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 651
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 652
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 652
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 653
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 653
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc aaggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggggttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 654
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 654
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Lys Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 655
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 655
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cgtggttacc aaggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggcggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggggttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 656
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 656
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Val Val Thr Lys Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Ala Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 657
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 657
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc ggtggttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 658
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 658
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Val Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 659
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 659
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc aaggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggaggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 660
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 660
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Lys Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 661
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 661
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 662
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 662
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 663
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 663
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggcggagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggggttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 664
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 664
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Ala Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 665
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 665
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 666
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 666
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 667
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 667
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc aaggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 668
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 668
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Lys Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 669
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 669
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cgtggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgac 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggcggagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 670
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 670
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Val Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Ala Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 671
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 671
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cgtggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 672
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 672
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Val Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 673
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 673
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggaggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 674
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 674
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 675
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 675
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggcggagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggggttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 676
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 676
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Ala Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 677
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 677
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggaggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 678
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 678
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 679
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 679
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc aaggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 680
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 680
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Lys Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 681
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 681
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 682
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 682
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 683
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 683
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cgtggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 684
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 684
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Val Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 685
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 685
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 686
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 686
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 687
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 687
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggggttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 688
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 688
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 689
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 689
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 690
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 690
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 691
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 691
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagcca 300
catattaatg tgggtgatgt cgtggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggaggagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 692
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 692
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Val Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 693
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 693
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 694
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 694
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 695
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 695
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgac 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 696
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 696
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 697
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 697
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagacga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 698
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 698
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 699
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 699
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 700
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 700
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 701
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 701
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 702
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 702
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 703
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 703
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 704
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 704
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 705
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 705
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaggagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 706
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 706
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 707
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 707
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgac 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggaggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 708
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 708
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 709
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 709
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggcggagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 710
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 710
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Ala Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 711
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 711
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc aaggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 712
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 712
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Lys Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 713
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 713
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggcggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggggttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 714
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 714
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Ala Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 715
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 715
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggaggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggggttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 716
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 716
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 717
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 717
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggcggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 718
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 718
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Ala Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 719
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 719
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 720
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 720
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 721
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 721
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgac 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 722
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 722
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 723
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 723
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggaggagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 724
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 724
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 725
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 725
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cgtggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 726
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 726
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Val Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 727
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 727
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggaggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 728
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 728
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 729
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 729
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 730
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 730
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 731
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 731
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggcggagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc gggggttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 732
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 732
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Ala Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 733
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 733
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 734
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 734
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 735
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 735
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 736
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 736
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 737
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 737
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggaggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 738
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 738
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 739
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 739
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 740
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 740
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 741
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 741
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 742
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 742
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 743
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 743
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc aaggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgac 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 744
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 744
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Lys Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 745
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 745
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc aaggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgac 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggaggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 746
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 746
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Lys Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 747
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 747
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtggc gggggttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 748
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 748
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 749
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 749
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagacga tgaaacaaac cgaaagccat 720
gccgtgaaaa tcgtggtaga agcggcgcgt cgtctgctg                        759

 
<210> 750
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 750
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Ala Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 751
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 751
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggcggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 752
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 752
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Ala Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 753
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 753
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgac 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 754
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 754
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 755
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 755
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggcggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatgatggc ggtggttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 756
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 756
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Ala Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Met Ala Val Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 757
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 757
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatcccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 758
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 758
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 759
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 759
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgac 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggcggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 760
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 760
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Ala Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 761
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 761
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cgtggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgac 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggaggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 762
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 762
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Val Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 763
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 763
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatctgt acgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc aaggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgac 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 764
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 764
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Val Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Lys Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 765
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 765
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cgtggttacc aaggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 766
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 766
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Val Val Thr Lys Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 767
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 767
atgtccaaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatctca tcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtctga tggcggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 768
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 768
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Leu Met Ala Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 769
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 769
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggatcgt gtggaatata tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagcca 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctggc 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaggagtg gcaggcaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 770
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 770
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Tyr Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Gly 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Ala Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 771
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 771
atgtccaagt ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tccctggcga cccggatcgt gtggaaaaga tcgccgcgct gatggataag 120
ccggttaagc tggcatctca ccgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta catcgggcgc tattcaggaa 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggtagca tggaggagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gattccgaat gctgagacga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 772
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 772
Met Ser Lys Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser His Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Ser Gly 
                85                  90                  95      
Ala Ile Gln Glu His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Ile Pro Asn Ala Glu Thr Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 773
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 773
atgtccgaat ctgatagttt tcatctgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataaa 120
ccggttaagc tggcacagtg gcgcgaattc actagctggc gtgcagagct ggatggtaaa 180
cctgttgttg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcac tattcagcca 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
aagggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 774
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 774
Met Ser Glu Ser Asp Ser Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Gln Trp Arg 
        35                  40                  45              
Glu Phe Thr Ser Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Val Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Thr Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 775
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 775
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 776
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 776
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 777
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 777
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 778
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 778
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 779
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 779
atgtccgaat ctgatagttt tcatctgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actagctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacctg 540
cagggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc gagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 780
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 780
Met Ser Glu Ser Asp Ser Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Ser Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Leu Gln Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 781
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 781
atgtccgaat ctgatgtatt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcac tattcagggg 300
catattaatg tgggtgaggt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacctg 540
aagggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgctc gagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gaagagtcga tgaaacaaac tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 782
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 782
Met Ser Glu Ser Asp Val Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Thr Ile Gln Gly His Ile Asn Val Gly Glu Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Leu Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ser Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Glu Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 783
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 783
atgtccgaat ctgatgtatt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcacagtg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcac tattcagggg 300
catattaatg tgggtgaggt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgactgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcagcgcatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgctc gagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gaagagtcga tgaaacaaac tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 784
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 784
Met Ser Glu Ser Asp Val Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Gln Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Thr Ile Gln Gly His Ile Asn Val Gly Glu Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Asp Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ser Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Glu Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 785
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 785
atgtccgaat ctgatagttt tcatctgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttgtcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcagcgcatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac tgaaagccat 720
atgatcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 786
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 786
Met Ser Glu Ser Asp Ser Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Val Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Ile Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 787
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 787
atgtccgaat ctgatgtgtt tcatctgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actagttggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 788
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 788
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Ser Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 789
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 789
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacttggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatctg 540
aagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc gagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 790
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 790
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Leu Lys Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 791
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 791
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actagttggc gtgcagagct ggatggtaaa 180
cctgttgtcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 792
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 792
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Ser Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Val Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 793
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 793
atgtccgaat ctgatagctt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 794
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 794
Met Ser Glu Ser Asp Ser Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 795
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 795
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgtttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 796
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 796
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 797
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 797
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacctg 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 798
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 798
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Leu Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 799
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 799
atgtccgaat ctgatgtttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 800
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 800
Met Ser Glu Ser Asp Val Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 801
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 801
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcag tagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 802
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 802
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ser Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 803
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 803
atgtccgaat ctgatgtgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actagttggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
aagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac tgaaagccat 720
atgatcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 804
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 804
Met Ser Glu Ser Asp Val Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Ser Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Ile Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 805
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 805
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt ggaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 806
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 806
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 807
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 807
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttgttg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 808
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 808
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Val Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 809
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 809
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 810
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 810
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 811
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 811
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcac cattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 812
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 812
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Thr Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 813
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 813
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc acttcgtggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 814
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 814
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Ser Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 815
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 815
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 816
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 816
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 817
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 817
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
caaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 818
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 818
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 819
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 819
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggccacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 820
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 820
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 821
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 821
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcacaatg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 822
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 822
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Gln Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 823
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 823
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gaagagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 824
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 824
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Glu Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 825
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 825
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgattgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 826
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 826
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Asp Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 827
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 827
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
ctgctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 828
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 828
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Leu Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 829
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 829
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcaggacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 830
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 830
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Asp Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 831
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 831
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atgatcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 832
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 832
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Ile Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 833
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 833
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggcgcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 834
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 834
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 835
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 835
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 836
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 836
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 837
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 837
atgtccgaat ctgatgtgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacttggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcatttt 540
cagggttcta tggaagagtg gcagcgcatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac tgaaagccat 720
atgatcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 838
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 838
Met Ser Glu Ser Asp Val Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Gln Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Ile Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 839
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 839
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 840
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 840
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 841
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 841
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgaagt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 842
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 842
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Glu Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 843
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 843
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgcggctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 844
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 844
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Ala Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 845
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 845
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
gcagttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 846
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 846
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Ala Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 847
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 847
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaagaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 848
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 848
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Glu Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 849
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 849
atgtccgaat ctgatgtttt tcatctcggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggatcgt gtggaaaaaa tcgccgcgct gatggataag 120
ccggttaagc tggcatcttg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttatcg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagccg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ctgcacttcg caccgctgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcacttt 540
aaaggttcta tggaagagtg gcagcgtatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccggat gctgagtcga tgaaacaaac cgaaagccat 720
atggtgaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 850
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 850
Met Ser Glu Ser Asp Val Phe His Leu Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Asp Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Lys Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Pro His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Leu His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg His Phe Lys Gly Ser Met Glu Glu Trp Gln Arg Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asp Ala Glu Ser Met Lys Gln Thr Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 851
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 851
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 852
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 852
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 853
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 853
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggaattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 854
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 854
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 855
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 855
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gctgccgaat gttgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 856
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 856
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Leu Pro Asn Val Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 857
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 857
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gctgccgaat gttgaggaca tgaaatgggt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 858
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 858
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Leu Pro Asn Val Glu Asp Met Lys Trp Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 859
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 859
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 860
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 860
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 861
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 861
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgttacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gttgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 862
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 862
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Val Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 863
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 863
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaatacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgaaaggggt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 864
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 864
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gly Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 865
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 865
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gttgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 866
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 866
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Val Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 867
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Pyruvate oxidase
 
<400> 867
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 868
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Pyruvate oxidase
 
<400> 868
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 869
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 869
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 870
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 870
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 871
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 871
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgttacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 872
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 872
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 873
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 873
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggaattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaatacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 874
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 874
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 875
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 875
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 876
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 876
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 877
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 877
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gatgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 878
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 878
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Met Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 879
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 879
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gttgagagta tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 880
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 880
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Val Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 881
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 881
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gctgccgaat gctgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 882
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 882
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 883
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 883
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatgccgaat gctgagagta tgaaatgggt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 884
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 884
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Met Pro Asn Ala Glu Ser Met Lys Trp Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 885
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 885
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gctgccgaat gttgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 886
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 886
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Leu Pro Asn Val Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 887
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 887
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgttacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagagta tgaaaggggt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 888
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 888
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gly Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 889
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 889
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 890
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 890
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 891
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 891
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgttacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gatgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 892
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 892
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Met Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 893
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 893
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gctgccgaat gttgagagta tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 894
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 894
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Leu Pro Asn Val Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 895
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 895
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgttacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 896
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 896
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 897
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 897
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 898
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 898
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 899
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 899
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gttgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 900
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 900
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Val Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 901
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 901
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgttacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 902
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 902
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Met Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 903
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 903
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaatacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 904
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 904
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 905
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 905
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 906
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 906
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 907
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 907
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 908
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 908
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 909
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 909
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 910
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 910
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 911
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 911
atgtccgagt ctgatagttt tgctatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcact gatggataac 120
ccagttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttctggcgg cgaaatcctg cggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgc cgtctgctg                        759

 
<210> 912
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 912
Met Ser Glu Ser Asp Ser Phe Ala Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Leu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 913
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 913
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccagct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgttacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 914
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 914
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Met Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 915
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 915
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaatacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 916
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 916
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 917
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 917
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcacgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgttacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgaaaggggt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 918
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 918
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Thr Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gly Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 919
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 919
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagagta tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 920
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 920
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 921
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 921
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaatacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gttgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 922
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 922
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Val Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 923
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 923
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatgccgaat gctgagtcga tgaaacaggt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 924
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 924
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Met Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 925
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 925
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 926
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 926
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Met Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 927
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 927
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgttacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gatgccgaat gctgagagta tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 928
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 928
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Met Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 929
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 929
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 930
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 930
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 931
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 931
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggata tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 932
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 932
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 933
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 933
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 934
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 934
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 935
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 935
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 936
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 936
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 937
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 937
atgtccgagt ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgctatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccattct gatggataac 120
ccagttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgagtgtac gactgcgctg 420
gttgaagggg cgaaatcctg cggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgc cgtctgctg                        759

 
<210> 938
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 938
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ile Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Gly Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 939
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 939
atgtccgagt ctgatagttt tgctatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccattct gatggataac 120
ccagttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagggg cgaaatccat gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgggccaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgc cgtctgctg                        759

 
<210> 940
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 940
Met Ser Glu Ser Asp Ser Phe Ala Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ile Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Gly Ala 
    130                 135                 140                 
Lys Ser Met Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Gly Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 941
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 941
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgccgcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 942
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 942
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Pro Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 943
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 943
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgctatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgagtgtac gactgcgctg 420
gttgaagggg cgaaatcctg cggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgggccaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgc cgtctgctg                        759

 
<210> 944
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 944
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Gly Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Gly Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 945
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 945
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gctgccgaat gctgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 946
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 946
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 947
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 947
atgtccgagt ctgatagttt tgctatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgctatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgagtgtac gactgcgctg 420
gttgaagctg cgaaatccat gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgggccaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgc cgtctgctg                        759

 
<210> 948
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 948
Met Ser Glu Ser Asp Ser Phe Ala Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Met Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Gly Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 949
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 949
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgttacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatgccgaat gctgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 950
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 950
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Met Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 951
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 951
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagagta tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 952
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 952
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 953
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 953
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 954
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 954
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 955
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 955
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaatacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gttgagagta tgaaatgggt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 956
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 956
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Val Glu Ser Met Lys Trp Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 957
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 957
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaatacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 958
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 958
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 959
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 959
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaagtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 960
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 960
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Met Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 961
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 961
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccattct gatggataac 120
ccagttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatc 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgagtgtac gactgcgctg 420
gttgaagggg cgaaatcctg cggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgggccaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgc cgtctgctg                        759

 
<210> 962
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 962
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ile Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Gly Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Gly Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 963
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 963
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 964
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 964
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 965
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 965
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
tgggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccagct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gctgccgaat gctgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 966
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 966
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Trp Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 967
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 967
atgtccgagt ctgatagttt tgctatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgctatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccattct gatggataac 120
ccagttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgagtgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgggccaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgc cgtctgctg                        759

 
<210> 968
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 968
Met Ser Glu Ser Asp Ser Phe Ala Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ile Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Gly Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 969
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 969
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 970
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 970
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 971
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 971
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagagta tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 972
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 972
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 973
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 973
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 974
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 974
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 975
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 975
atgtccgagt ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttggtatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccagttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagcgg cgaaatcctg cggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgggccaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcggcc cgtctgctg                        759

 
<210> 976
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 976
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Gly Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Gly Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Ala Arg Leu Leu             
                245                 250             

 
<210> 977
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 977
atgtccaact ctgatagttt tgctatgggc ctcactaaaa acgatttaca aggggctacg 60
cttggtatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccattct gatggataac 120
ccagttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgagtgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgggccaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcggcc cgtctgctg                        759

 
<210> 978
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 978
Met Ser Asn Ser Asp Ser Phe Ala Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Gly Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ile Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Gly Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Ala Arg Leu Leu             
                245                 250             

 
<210> 979
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 979
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatg 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgtgtgtac gactgcgctg 420
gttgaagctg cgaaatcctg cggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgc cgtctgctg                        759

 
<210> 980
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 980
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Met 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Val Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 981
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 981
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
tgggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtacagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 982
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 982
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Trp Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Met Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 983
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 983
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaatacatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagagta tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 984
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 984
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 985
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 985
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 986
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 986
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 987
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 987
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctttg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 988
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 988
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Leu Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 989
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 989
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcgagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg gcaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagggcga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 990
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 990
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 991
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 991
atgtccgagt ctgatagttt tgctatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgctatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatc 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagcgg cgaaatcctg cggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcggcc cgtctgctg                        759

 
<210> 992
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 992
Met Ser Glu Ser Asp Ser Phe Ala Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Ala Arg Leu Leu             
                245                 250             

 
<210> 993
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 993
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaatgggt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 994
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 994
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Trp Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 995
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 995
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gagggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 996
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 996
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 997
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 997
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccaggggga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 998
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 998
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gly Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 999
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 999
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gatgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1000
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1000
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Met Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1001
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1001
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
tgggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1002
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1002
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Trp Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1003
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1003
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtatga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1004
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1004
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1005
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1005
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagcttt 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1006
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1006
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser Phe 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1007
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1007
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agtgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1008
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1008
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1009
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1009
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gtggagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1010
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1010
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Val Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1011
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1011
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaaggggt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1012
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1012
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gly Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1013
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1013
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaaattgt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1014
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1014
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Ile Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1015
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1015
atgtccgaat ctgatacttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1016
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1016
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1017
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1017
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccggag gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1018
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1018
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Glu Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1019
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1019
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg ttcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1020
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1020
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1021
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1021
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ggaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1022
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1022
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Gly 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1023
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1023
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1024
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1024
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1025
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1025
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1026
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1026
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1027
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1027
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggttatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1028
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1028
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1029
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1029
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tgacgagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1030
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1030
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Thr Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1031
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1031
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcagtatatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1032
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1032
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Tyr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1033
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1033
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccattct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1034
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1034
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ile Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1035
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1035
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat gggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1036
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1036
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Met Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1037
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1037
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggatgtg 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1038
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1038
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Val Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1039
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1039
atgtccgaat ctgatagttt tgcgatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1040
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1040
Met Ser Glu Ser Asp Ser Phe Ala Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1041
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1041
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcacagtg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1042
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1042
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Gln Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1043
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1043
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgcagga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1044
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1044
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Gln Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1045
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1045
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcggcg cgtctgctg                        759

 
<210> 1046
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1046
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Ala Arg Leu Leu             
                245                 250             

 
<210> 1047
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1047
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttcctc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1048
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1048
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Pro Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1049
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1049
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgtttgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1050
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1050
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Val Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1051
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1051
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccggtgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1052
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1052
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Val Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1053
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1053
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
aggggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1054
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1054
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1055
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1055
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagtc ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1056
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1056
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Ser Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1057
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1057
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttggtatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1058
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1058
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Gly Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1059
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1059
atgtccgaat ctgatagttt tcatgtgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1060
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1060
Met Ser Glu Ser Asp Ser Phe His Val Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1061
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1061
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tggggcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1062
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1062
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Gly Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1063
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1063
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttctggctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1064
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1064
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Leu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1065
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1065
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaagcggt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1066
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1066
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Ala Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1067
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1067
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagggg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1068
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1068
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Gly Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1069
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1069
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ggggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1070
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1070
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Gly Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1071
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1071
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattgggg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1072
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1072
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1073
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1073
atgtccaatt ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1074
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1074
Met Ser Asn Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1075
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1075
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcagacgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1076
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1076
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Thr Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1077
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1077
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgctg tagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1078
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1078
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Cys Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1079
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1079
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggtgacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1080
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1080
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Val Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1081
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1081
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagac ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1082
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1082
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Thr Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1083
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1083
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggatctg 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1084
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1084
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Leu Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1085
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1085
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatg 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1086
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1086
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Met 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1087
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1087
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgg tagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1088
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1088
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Gly Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1089
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1089
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct gacgggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1090
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1090
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Thr Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1091
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1091
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggctttaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1092
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1092
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Phe Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1093
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1093
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gcttcttcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1094
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1094
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Ser Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1095
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1095
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagctgg 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1096
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1096
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser Trp 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1097
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1097
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgcttga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1098
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1098
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Leu Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1099
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1099
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
cttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1100
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1100
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Leu Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1101
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1101
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggccttcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1102
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1102
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Leu Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1103
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1103
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg cgaaagtgat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1104
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1104
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Val Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1105
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1105
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttattgctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1106
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1106
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Ile Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1107
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1107
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggcaagctg gcgcgaattc actacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatc ttgaatgtac gactgcgctg 420
gttgaagctg cgaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcaggaaatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1108
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1108
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Ala Ser Trp Arg 
        35                  40                  45              
Glu Phe Thr Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Leu Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Gln Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1109
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1109
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattgggg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat cggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgccgcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1110
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1110
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Pro Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1111
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1111
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat cggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgccgcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1112
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1112
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Pro Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1113
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1113
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggcaatg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccac 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1114
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1114
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Gln Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1115
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1115
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattgggg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agttcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1116
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1116
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1117
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1117
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggcaatg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgccgcaagt tgaaagcttc 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1118
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1118
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Gln Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Pro Gln Val Glu Ser Phe 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1119
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1119
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggtcgtg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat cggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaagcaagt tgaaagccac 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1120
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1120
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1121
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1121
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccggaa gctgaggaca tgccgcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1122
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1122
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Glu Ala Glu Asp Met Pro Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1123
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1123
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggtcgtg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgaagcaagt tgaaagccac 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1124
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1124
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1125
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1125
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggtcgtg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattgggg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1126
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1126
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1127
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1127
atgtccgaat ctgattcgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccggaa gctgagtcga tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1128
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1128
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Glu Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1129
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1129
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1130
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1130
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1131
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1131
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattgggg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1132
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1132
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1133
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1133
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattgggg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgccgcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1134
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1134
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Pro Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1135
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1135
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggcaatg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagcttc 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1136
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1136
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Gln Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser Phe 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1137
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1137
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggtcgtg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat cggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgccgcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1138
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1138
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Pro Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1139
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1139
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggtcgtg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1140
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1140
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1141
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1141
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggtcgtg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgccgcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1142
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1142
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Pro Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1143
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1143
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattgggg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccggaa gctgaggaca tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1144
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1144
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Glu Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1145
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1145
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccac 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1146
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1146
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1147
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1147
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttccac tggggcaatg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1148
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1148
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Pro Leu Gly Gln Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1149
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1149
atgtccgaat ctgatacgtt tgcagtgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1150
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1150
Met Ser Glu Ser Asp Thr Phe Ala Val Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1151
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1151
atgtccgaat ctgattcgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttccac tggggcaatg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagcttc 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1152
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1152
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Pro Leu Gly Gln Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser Phe 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1153
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1153
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggcaatg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagcttc 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1154
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1154
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Gln Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser Phe 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1155
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1155
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggcaatg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agttcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccggaa gctgaggaca tgccgcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1156
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1156
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Gln Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Glu Ala Glu Asp Met Pro Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1157
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1157
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggtcgtg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat cggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1158
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1158
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1159
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1159
atgtccgaat ctgattcgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggcaatg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1160
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1160
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Gln Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1161
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1161
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agttcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1162
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1162
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1163
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1163
atgtccgaat ctgattcgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttccac tggggcaatg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccggaa gctgagtcga tgccgcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1164
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1164
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Pro Leu Gly Gln Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Glu Ala Glu Ser Met Pro Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1165
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1165
atgtccgaat ctgattcgtt tcatgtgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggcaatg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1166
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1166
Met Ser Glu Ser Asp Ser Phe His Val Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Gln Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1167
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1167
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattgggg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1168
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1168
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1169
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1169
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggcaatg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattgggg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agttcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1170
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1170
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Gln Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1171
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1171
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggtcgtg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccggaa gctgaggaca tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1172
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1172
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Glu Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1173
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1173
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttccac tggggtcgtg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1174
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1174
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Pro Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1175
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1175
atgtccgaat ctgatacgtt tcatgtgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgccgcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1176
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1176
Met Ser Glu Ser Asp Thr Phe His Val Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Pro Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1177
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1177
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1178
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1178
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1179
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1179
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agttcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1180
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1180
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1181
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1181
atgtccgaat ctgattcgtt tcatgtgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttccac tggggcaatg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattgggg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgaagcaagt tgaaagctgg 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1182
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1182
Met Ser Glu Ser Asp Ser Phe His Val Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Pro Leu Gly Gln Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser Trp 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1183
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1183
atgtccgaat ctgatacgtt tcatgtgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat cggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agttcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgccgcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1184
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1184
Met Ser Glu Ser Asp Thr Phe His Val Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Pro Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1185
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1185
atgtccgaat ctgatagttt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttccac tggggtcgtg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattgggg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc agttcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgaggaca tgaagcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1186
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1186
Met Ser Glu Ser Asp Ser Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Pro Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Val 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Asp Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1187
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1187
atgtccgaat ctgatacgtt tcatgtgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcg tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcgtgagatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc aagtcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1188
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1188
Met Ser Glu Ser Asp Thr Phe His Val Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Val Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Arg Glu Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1189
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1189
atgtccgaat ctgattcgtt tcatgtgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggcaatg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgtacga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatcctg tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1190
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1190
Met Ser Glu Ser Asp Ser Phe His Val Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Gln Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Tyr Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Cys Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1191
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1191
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattgggg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cagggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1192
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1192
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Gly Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1193
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1193
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaagc tggggagttg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat tggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
caaggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccgaat gctgagtcga tgaaacaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1194
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1194
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Gln Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Asn Ala Glu Ser Met Lys Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1195
<211> 759
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1195
atgtccgaat ctgatacgtt tcatatgggc ctcactaaaa acgatttaca aggggctacg 60
cttgccatcc tgcctggcga cccggctcgt gtggaaaaaa tcgccgcgct gatggataac 120
ccggttaaac tggggtcgtg gcgcgaattc attacctggc gtgcagagct ggatggtaaa 180
cctgttattg tctgctctac cggtatcggc ggcccgtcta cctctattgc tgttgaaatt 240
ctggcacagc tgggcattcg caccttcctg cgtatcggta caacgggcgc tattcagggg 300
catattaatg tgggtgatgt cctggttacc acggcgtctg tccgtctgga tggcgcgagc 360
ggtcacttcg caccgatgga attcccggct gtcgctgatt tcgaatgtac gactgcgctg 420
gttgaagctg ccaaatccat cggcgcgaca actcacgttg gcgtgacagc ttcttctgat 480
accttctacc caggtcagga acgttacgat acttactctg gtcgcgtagt tcgtcgcttt 540
cgcggttcta tggaagagtg gcgtgtgatg ggcgtaatga actatgaaat ggaatctgca 600
accctgctga ccatgtgcgc atcgcagggc ctgcgtgccg gtatggtagc gggtgttatc 660
gttaaccgca cccagcaaga gctgccggaa gctgaggaca tgccgcaagt tgaaagccat 720
atggtcaaaa tcgtggtgga agcggcgcgt cgtctgctg                        759

 
<210> 1196
<211> 253
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of uridine phosphorylase
 
<400> 1196
Met Ser Glu Ser Asp Thr Phe His Met Gly Leu Thr Lys Asn Asp Leu 
1               5                   10                  15      
Gln Gly Ala Thr Leu Ala Ile Leu Pro Gly Asp Pro Ala Arg Val Glu 
            20                  25                  30          
Lys Ile Ala Ala Leu Met Asp Asn Pro Val Lys Leu Gly Ser Trp Arg 
        35                  40                  45              
Glu Phe Ile Thr Trp Arg Ala Glu Leu Asp Gly Lys Pro Val Ile Val 
    50                  55                  60                  
Cys Ser Thr Gly Ile Gly Gly Pro Ser Thr Ser Ile Ala Val Glu Ile 
65                  70                  75                  80  
Leu Ala Gln Leu Gly Ile Arg Thr Phe Leu Arg Ile Gly Thr Thr Gly 
                85                  90                  95      
Ala Ile Gln Gly His Ile Asn Val Gly Asp Val Leu Val Thr Thr Ala 
            100                 105                 110         
Ser Val Arg Leu Asp Gly Ala Ser Gly His Phe Ala Pro Met Glu Phe 
        115                 120                 125             
Pro Ala Val Ala Asp Phe Glu Cys Thr Thr Ala Leu Val Glu Ala Ala 
    130                 135                 140                 
Lys Ser Ile Gly Ala Thr Thr His Val Gly Val Thr Ala Ser Ser Asp 
145                 150                 155                 160 
Thr Phe Tyr Pro Gly Gln Glu Arg Tyr Asp Thr Tyr Ser Gly Arg Val 
                165                 170                 175     
Val Arg Arg Phe Arg Gly Ser Met Glu Glu Trp Arg Val Met Gly Val 
            180                 185                 190         
Met Asn Tyr Glu Met Glu Ser Ala Thr Leu Leu Thr Met Cys Ala Ser 
        195                 200                 205             
Gln Gly Leu Arg Ala Gly Met Val Ala Gly Val Ile Val Asn Arg Thr 
    210                 215                 220                 
Gln Gln Glu Leu Pro Glu Ala Glu Asp Met Pro Gln Val Glu Ser His 
225                 230                 235                 240 
Met Val Lys Ile Val Val Glu Ala Ala Arg Arg Leu Leu             
                245                 250             

 
<210> 1197
<211> 1224
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of MTR kinase
 
<400> 1197
atgagccagt atcatacctt caccgcggat gatgcggtgg cgtatgcgca gcaatttgcg 60
ggcattgata acccgagcga gctggttagc gcgcaagaag ttggtgacgg caacctgaac 120
ctggtgttca aggtttttga tcgtcagggt gtgagccgtg cgatcgttaa acaagcgctg 180
ccgtaccccc gtgcggttgg tccgagctgg ccgctgaccc tggaccgtgc gcgtcatgaa 240
gcgcagaccc tggtggcgca ctatcagcac agcccgcaac acaccgttaa gatccaccac 300
ttcgatccgg agctggcggt gatggttatg gaagacctga gcgatcaccg tatttggcgt 360
ggtgagctga tcgcgaacgt gtactatccg caggcggcgc gtcaactggg tgactacctg 420
gcgcaggttc tgttccacac cagcgatttt tatctgcacc cgcacgagaa gaaagcgcag 480
gtggcgcaat tcattaaccc gggcatgtgc gaaatcagcg aagacctgag ctttaacgat 540
ccgtaccaga ttcacgaacg taacaactat ccggcggagc tggaagcgga tgtggcggcg 600
ctgcgtgatg atgcgcaact gaagctggcg gttgcggcgc tgaaacaccg tttctttgcg 660
catgcggagg cgctgctgca tggtgacctt cacagcggca gcatcttcgt tgcggagggt 720
agcctgaagg tgatcgacgc ggaattcggt tactttggcc cgatcggttt tgatattggt 780
accgcgatcg gcaacctgct gctgaactat tgcggtctgc cgggtcaact gggtattcgt 840
gatgcggcgg cggcgcgtga acagcgtctg aacgatatcc accaactgtg gaccaccttc 900
gcggagcgtt ttcaagcgct ggcggcggaa aagacccgtg acgcggcgct ggcgtacccg 960
ggttatgcga gcgcgttcct gaagaaagtg tgggcggatg cggttggttt ttgcggcagc 1020
gagctgattc gtcgtagcgt gggcctgtcg cacgttgcgg acatcgatac cattcaggac 1080
gatgcgatgc gtcacgaatg cctgcgtcac gcgatcaccc tgggtcgtgc gctgattgtt 1140
ctggcggaga ccatcgacag cgtggatgaa ctgctggcgc gtgttcgtca atacagcctc 1200
gagcaccacc accaccacca ctga                                        1224

 
<210> 1198
<211> 407
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of MTR kinase
 
<400> 1198
Met Ser Gln Tyr His Thr Phe Thr Ala Asp Asp Ala Val Ala Tyr Ala 
1               5                   10                  15      
Gln Gln Phe Ala Gly Ile Asp Asn Pro Ser Glu Leu Val Ser Ala Gln 
            20                  25                  30          
Glu Val Gly Asp Gly Asn Leu Asn Leu Val Phe Lys Val Phe Asp Arg 
        35                  40                  45              
Gln Gly Val Ser Arg Ala Ile Val Lys Gln Ala Leu Pro Tyr Pro Arg 
    50                  55                  60                  
Ala Val Gly Pro Ser Trp Pro Leu Thr Leu Asp Arg Ala Arg His Glu 
65                  70                  75                  80  
Ala Gln Thr Leu Val Ala His Tyr Gln His Ser Pro Gln His Thr Val 
                85                  90                  95      
Lys Ile His His Phe Asp Pro Glu Leu Ala Val Met Val Met Glu Asp 
            100                 105                 110         
Leu Ser Asp His Arg Ile Trp Arg Gly Glu Leu Ile Ala Asn Val Tyr 
        115                 120                 125             
Tyr Pro Gln Ala Ala Arg Gln Leu Gly Asp Tyr Leu Ala Gln Val Leu 
    130                 135                 140                 
Phe His Thr Ser Asp Phe Tyr Leu His Pro His Glu Lys Lys Ala Gln 
145                 150                 155                 160 
Val Ala Gln Phe Ile Asn Pro Gly Met Cys Glu Ile Ser Glu Asp Leu 
                165                 170                 175     
Ser Phe Asn Asp Pro Tyr Gln Ile His Glu Arg Asn Asn Tyr Pro Ala 
            180                 185                 190         
Glu Leu Glu Ala Asp Val Ala Ala Leu Arg Asp Asp Ala Gln Leu Lys 
        195                 200                 205             
Leu Ala Val Ala Ala Leu Lys His Arg Phe Phe Ala His Ala Glu Ala 
    210                 215                 220                 
Leu Leu His Gly Asp Leu His Ser Gly Ser Ile Phe Val Ala Glu Gly 
225                 230                 235                 240 
Ser Leu Lys Val Ile Asp Ala Glu Phe Gly Tyr Phe Gly Pro Ile Gly 
                245                 250                 255     
Phe Asp Ile Gly Thr Ala Ile Gly Asn Leu Leu Leu Asn Tyr Cys Gly 
            260                 265                 270         
Leu Pro Gly Gln Leu Gly Ile Arg Asp Ala Ala Ala Ala Arg Glu Gln 
        275                 280                 285             
Arg Leu Asn Asp Ile His Gln Leu Trp Thr Thr Phe Ala Glu Arg Phe 
    290                 295                 300                 
Gln Ala Leu Ala Ala Glu Lys Thr Arg Asp Ala Ala Leu Ala Tyr Pro 
305                 310                 315                 320 
Gly Tyr Ala Ser Ala Phe Leu Lys Lys Val Trp Ala Asp Ala Val Gly 
                325                 330                 335     
Phe Cys Gly Ser Glu Leu Ile Arg Arg Ser Val Gly Leu Ser His Val 
            340                 345                 350         
Ala Asp Ile Asp Thr Ile Gln Asp Asp Ala Met Arg His Glu Cys Leu 
        355                 360                 365             
Arg His Ala Ile Thr Leu Gly Arg Ala Leu Ile Val Leu Ala Glu Thr 
    370                 375                 380                 
Ile Asp Ser Val Asp Glu Leu Leu Ala Arg Val Arg Gln Tyr Ser Leu 
385                 390                 395                 400 
Glu His His His His His His                                     
                405         

 
<210> 1199
<211> 1773
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Pyruvate oxidase
 
<400> 1199
atgacccagg gtaaaattac cgcaagtgcc gcaatgctga atgtgctgaa aacctggggc 60
gttgatacca tttatggtat tccgagtggt accctgagca gcctgatgga tgccttagca 120
gaagataaag atatccgctt tctgcaggtg cgccatgaag aaaccggcgc attagccgca 180
gtgatgcagg caaaatttgg tggcagcatt ggtgttgcag tgggtagcgg tggtccgggt 240
gcaacccacc tgatcaatgg tgtttatgat gccgccatgg ataatacccc gtttctggcc 300
attctgggta gtcgccctgt gaatgaactg aatatggatg cattccagga gctgaatcag 360
aatccgatgt atcatggtat cgccgtttat aataagcgcg ttgcatacgc tgaacagctg 420
ccgaaagtga ttgatgaagc atgccgtgca gccgtgagca aaaaaggccc tgcagtggtt 480
gaaattccgg ttaattttgg cttccaggaa atcgatgaga acagttatta cggcagcggt 540
agttatgaac gtagctttat tgccccggcc ctgaatgaag tggaaattga taaagcagtg 600
gagatcctga acaaggcaga acgcccggtg atttatgcag gctttggtgg cgtgaaagca 660
ggtgaagtga ttaccgaact gagccgcaaa attaaagccc cgattattac caccggcaaa 720
aattttgagg cctttgaatg gaactacgag ggactgaccg gcagtgcata tcgtgtgggt 780
tggaaaccgg caaatgaagt ggtgtttgaa gccgataccg tgctgtttct gggtagcaat 840
tttccgtttg ccgaagttta tgaggcattt aaaaacaccg agaagttcat ccaggtggat 900
attgatccgt ataagctggg caaacgtcat gcactggatg caagtattct gggtgatgca 960
ggtcaggccg caaaagcaat tctggataaa gttgatgccg tggaaagcac cccgtggtgg 1020
cgtgcaaatg tgaaaaataa tcagaactgg cgcgactata tgaacaaact ggaaggcaaa 1080
accgagggtg aactgcagct gtatcaggtt tataatgcca ttaacaagca cgcagaccag 1140
gatgcaattt atagtattga cgtgggcaac agcacccaga ccagtacacg tcatctgcac 1200
atgaccccga aaaatatgtg gcgtaccagc ccgctgtttg caaccatggg tattgccctg 1260
ccgggcggta ttgctgcaaa aaaagataat ccggagcgtc aggtttggaa tattatgggt 1320
gatggtgcct ttaacatgtg ctatccggat gtgattacca atgttcagta caatctgccg 1380
gttattaacg ttgttttcag caatgccgag tacgcattta ttaagaacaa gtacgaggac 1440
accaacaagc atctgtttgg tgttgatttc accaacgccg attatgccaa aattgccgaa 1500
gcacagggcg cagttggttt taccgtggat cgcattgaag atattgacgc agtggttgcc 1560
gaagcagtga aactgaataa agaaggtaag accgtggtga ttgacgcccg cattacccag 1620
catcgccctt tacctgtgga agtgctggaa ctggatccga aactgcatag tgaagaagca 1680
attaaggcct ttaaggagaa gtacgaagcc gaagaactgg tgccgtttcg tctgtttctg 1740
gaagaagaag gcctgcagag tcgcgcaatt aaa                              1773

 
<210> 1200
<211> 591
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Pyruvate oxidase
 
<400> 1200
Met Thr Gln Gly Lys Ile Thr Ala Ser Ala Ala Met Leu Asn Val Leu 
1               5                   10                  15      
Lys Thr Trp Gly Val Asp Thr Ile Tyr Gly Ile Pro Ser Gly Thr Leu 
            20                  25                  30          
Ser Ser Leu Met Asp Ala Leu Ala Glu Asp Lys Asp Ile Arg Phe Leu 
        35                  40                  45              
Gln Val Arg His Glu Glu Thr Gly Ala Leu Ala Ala Val Met Gln Ala 
    50                  55                  60                  
Lys Phe Gly Gly Ser Ile Gly Val Ala Val Gly Ser Gly Gly Pro Gly 
65                  70                  75                  80  
Ala Thr His Leu Ile Asn Gly Val Tyr Asp Ala Ala Met Asp Asn Thr 
                85                  90                  95      
Pro Phe Leu Ala Ile Leu Gly Ser Arg Pro Val Asn Glu Leu Asn Met 
            100                 105                 110         
Asp Ala Phe Gln Glu Leu Asn Gln Asn Pro Met Tyr His Gly Ile Ala 
        115                 120                 125             
Val Tyr Asn Lys Arg Val Ala Tyr Ala Glu Gln Leu Pro Lys Val Ile 
    130                 135                 140                 
Asp Glu Ala Cys Arg Ala Ala Val Ser Lys Lys Gly Pro Ala Val Val 
145                 150                 155                 160 
Glu Ile Pro Val Asn Phe Gly Phe Gln Glu Ile Asp Glu Asn Ser Tyr 
                165                 170                 175     
Tyr Gly Ser Gly Ser Tyr Glu Arg Ser Phe Ile Ala Pro Ala Leu Asn 
            180                 185                 190         
Glu Val Glu Ile Asp Lys Ala Val Glu Ile Leu Asn Lys Ala Glu Arg 
        195                 200                 205             
Pro Val Ile Tyr Ala Gly Phe Gly Gly Val Lys Ala Gly Glu Val Ile 
    210                 215                 220                 
Thr Glu Leu Ser Arg Lys Ile Lys Ala Pro Ile Ile Thr Thr Gly Lys 
225                 230                 235                 240 
Asn Phe Glu Ala Phe Glu Trp Asn Tyr Glu Gly Leu Thr Gly Ser Ala 
                245                 250                 255     
Tyr Arg Val Gly Trp Lys Pro Ala Asn Glu Val Val Phe Glu Ala Asp 
            260                 265                 270         
Thr Val Leu Phe Leu Gly Ser Asn Phe Pro Phe Ala Glu Val Tyr Glu 
        275                 280                 285             
Ala Phe Lys Asn Thr Glu Lys Phe Ile Gln Val Asp Ile Asp Pro Tyr 
    290                 295                 300                 
Lys Leu Gly Lys Arg His Ala Leu Asp Ala Ser Ile Leu Gly Asp Ala 
305                 310                 315                 320 
Gly Gln Ala Ala Lys Ala Ile Leu Asp Lys Val Asp Ala Val Glu Ser 
                325                 330                 335     
Thr Pro Trp Trp Arg Ala Asn Val Lys Asn Asn Gln Asn Trp Arg Asp 
            340                 345                 350         
Tyr Met Asn Lys Leu Glu Gly Lys Thr Glu Gly Glu Leu Gln Leu Tyr 
        355                 360                 365             
Gln Val Tyr Asn Ala Ile Asn Lys His Ala Asp Gln Asp Ala Ile Tyr 
    370                 375                 380                 
Ser Ile Asp Val Gly Asn Ser Thr Gln Thr Ser Thr Arg His Leu His 
385                 390                 395                 400 
Met Thr Pro Lys Asn Met Trp Arg Thr Ser Pro Leu Phe Ala Thr Met 
                405                 410                 415     
Gly Ile Ala Leu Pro Gly Gly Ile Ala Ala Lys Lys Asp Asn Pro Glu 
            420                 425                 430         
Arg Gln Val Trp Asn Ile Met Gly Asp Gly Ala Phe Asn Met Cys Tyr 
        435                 440                 445             
Pro Asp Val Ile Thr Asn Val Gln Tyr Asn Leu Pro Val Ile Asn Val 
    450                 455                 460                 
Val Phe Ser Asn Ala Glu Tyr Ala Phe Ile Lys Asn Lys Tyr Glu Asp 
465                 470                 475                 480 
Thr Asn Lys His Leu Phe Gly Val Asp Phe Thr Asn Ala Asp Tyr Ala 
                485                 490                 495     
Lys Ile Ala Glu Ala Gln Gly Ala Val Gly Phe Thr Val Asp Arg Ile 
            500                 505                 510         
Glu Asp Ile Asp Ala Val Val Ala Glu Ala Val Lys Leu Asn Lys Glu 
        515                 520                 525             
Gly Lys Thr Val Val Ile Asp Ala Arg Ile Thr Gln His Arg Pro Leu 
    530                 535                 540                 
Pro Val Glu Val Leu Glu Leu Asp Pro Lys Leu His Ser Glu Glu Ala 
545                 550                 555                 560 
Ile Lys Ala Phe Lys Glu Lys Tyr Glu Ala Glu Glu Leu Val Pro Phe 
                565                 570                 575     
Arg Leu Phe Leu Glu Glu Glu Gly Leu Gln Ser Arg Ala Ile Lys     
            580                 585                 590     

