                         SEQUENCE LISTING

<110>  Helmholtz Zentrum Mnchen Deutsches Forschungszentrum fr 
       Gesundheit und Umwelt (GmbH)
 
<120>  APPLICATION OF CRISPR/CAS13 FOR THERAPY OF RNA VIRUS AND/OR 
       BACTERIUM INDUCED DISEASES

<130>  HEL17177PCT

<150>  LU 102326
<151>  2020-12-22

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  967
<212>  PRT
<213>  Rumniococcus flavefaciens

<400>  1

Met Ile Glu Lys Lys Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser 
1               5                   10                  15      


Thr Leu Val Ser Gly Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly 
            20                  25                  30          


Ser Asp Ala Arg Leu Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser 
        35                  40                  45              


Val Asn Glu Gly Glu Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala 
    50                  55                  60                  


Gly Tyr Lys Ile Gly Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala 
65                  70                  75                  80  


Val Val Ala Asn Asn Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met 
                85                  90                  95      


Leu Gly Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala 
            100                 105                 110         


Asp Gly Asn Asp Asn Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp 
        115                 120                 125             


Ile Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val 
    130                 135                 140                 


Asn Asn Ile Ser Gly Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe 
145                 150                 155                 160 


Ser Thr Val Tyr Thr Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg 
                165                 170                 175     


Ala Ala Phe Asn Asn Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln 
            180                 185                 190         


Tyr Asp Glu Phe Asp Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe 
        195                 200                 205             


Gly Gln Ala Phe Phe Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr 
    210                 215                 220                 


Gly Asn Glu Cys Tyr Asp Ile Leu Ala Leu Leu Ser Gly Leu Arg His 
225                 230                 235                 240 


Trp Val Val His Asn Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp 
                245                 250                 255     


Leu Tyr Asn Leu Asp Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu 
            260                 265                 270         


Asn Tyr Leu Tyr Asp Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser 
        275                 280                 285             


Lys Asn Ser Ala Ala Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile 
    290                 295                 300                 


Asn Pro Ala Glu Phe Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys 
305                 310                 315                 320 


Glu Gln Lys Asn Leu Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met 
                325                 330                 335     


Leu Asp Arg Lys Asp Met Ser Glu Ile Arg Lys Asn His Lys Val Phe 
            340                 345                 350         


Asp Ser Ile Arg Thr Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr 
        355                 360                 365             


Arg Tyr Tyr Ile Glu Glu Asp Ala Lys Val Ala Ala Ala Asn Lys Ser 
    370                 375                 380                 


Leu Pro Asp Asn Glu Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile 
385                 390                 395                 400 


Asn Leu Arg Gly Ser Phe Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr 
                405                 410                 415     


Asp Glu Ala Asn Arg Ile Trp Arg Lys Leu Glu Asn Ile Met His Asn 
            420                 425                 430         


Ile Lys Glu Phe Arg Gly Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp 
        435                 440                 445             


Ala Pro Arg Leu Pro Arg Ile Leu Pro Ala Gly Arg Asp Val Ser Ala 
    450                 455                 460                 


Phe Ser Lys Leu Met Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu 
465                 470                 475                 480 


Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln 
                485                 490                 495     


Ser Phe Leu Lys Val Met Pro Leu Ile Gly Val Asn Ala Lys Phe Val 
            500                 505                 510         


Glu Glu Tyr Ala Phe Phe Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu 
        515                 520                 525             


Arg Leu Ile Lys Ser Phe Ala Arg Met Gly Glu Pro Ile Ala Asp Ala 
    530                 535                 540                 


Arg Arg Ala Met Tyr Ile Asp Ala Ile Arg Ile Leu Gly Thr Asn Leu 
545                 550                 555                 560 


Ser Tyr Asp Glu Leu Lys Ala Leu Ala Asp Thr Phe Ser Leu Asp Glu 
                565                 570                 575     


Asn Gly Asn Lys Leu Lys Lys Gly Lys His Gly Met Arg Asn Phe Ile 
            580                 585                 590         


Ile Asn Asn Val Ile Ser Asn Lys Arg Phe His Tyr Leu Ile Arg Tyr 
        595                 600                 605             


Gly Asp Pro Ala His Leu His Glu Ile Ala Lys Asn Glu Ala Val Val 
    610                 615                 620                 


Lys Phe Val Leu Gly Arg Ile Ala Asp Ile Gln Lys Lys Gln Gly Gln 
625                 630                 635                 640 


Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys Ile Gly Lys 
                645                 650                 655     


Asp Lys Gly Lys Ser Val Ser Glu Lys Val Asp Ala Leu Thr Lys Ile 
            660                 665                 670         


Ile Thr Gly Met Asn Tyr Asp Gln Phe Asp Lys Lys Arg Ser Val Ile 
        675                 680                 685             


Glu Asp Thr Gly Arg Glu Asn Ala Glu Arg Glu Lys Phe Lys Lys Ile 
    690                 695                 700                 


Ile Ser Leu Tyr Leu Thr Val Ile Tyr His Ile Leu Lys Asn Ile Val 
705                 710                 715                 720 


Asn Ile Asn Ala Arg Tyr Val Ile Gly Phe His Cys Val Glu Arg Asp 
                725                 730                 735     


Ala Gln Leu Tyr Lys Glu Lys Gly Tyr Asp Ile Asn Leu Lys Lys Leu 
            740                 745                 750         


Glu Glu Lys Gly Phe Ser Ser Val Thr Lys Leu Cys Ala Gly Ile Asp 
        755                 760                 765             


Glu Thr Ala Pro Asp Lys Arg Lys Asp Val Glu Lys Glu Met Ala Glu 
    770                 775                 780                 


Arg Ala Lys Glu Ser Ile Asp Ser Leu Glu Ser Ala Asn Pro Lys Leu 
785                 790                 795                 800 


Tyr Ala Asn Tyr Ile Lys Tyr Ser Asp Glu Lys Lys Ala Glu Glu Phe 
                805                 810                 815     


Thr Arg Gln Ile Asn Arg Glu Lys Ala Lys Thr Ala Leu Asn Ala Tyr 
            820                 825                 830         


Leu Arg Asn Thr Lys Trp Asn Val Ile Ile Arg Glu Asp Leu Leu Arg 
        835                 840                 845             


Ile Asp Asn Lys Thr Cys Thr Leu Phe Arg Asn Lys Ala Val His Leu 
    850                 855                 860                 


Glu Val Ala Arg Tyr Val His Ala Tyr Ile Asn Asp Ile Ala Glu Val 
865                 870                 875                 880 


Asn Ser Tyr Phe Gln Leu Tyr His Tyr Ile Met Gln Arg Ile Ile Met 
                885                 890                 895     


Asn Glu Arg Tyr Glu Lys Ser Ser Gly Lys Val Ser Glu Tyr Phe Asp 
            900                 905                 910         


Ala Val Asn Asp Glu Lys Lys Tyr Asn Asp Arg Leu Leu Lys Leu Leu 
        915                 920                 925             


Cys Val Pro Phe Gly Tyr Cys Ile Pro Arg Phe Lys Asn Leu Ser Ile 
    930                 935                 940                 


Glu Ala Leu Phe Asp Arg Asn Glu Ala Ala Lys Phe Asp Lys Glu Lys 
945                 950                 955                 960 


Lys Lys Val Ser Gly Asn Ser 
                965         


<210>  2
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  SV40 NLS

<400>  2

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  3
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  NLS consensus sequence

<400>  3

Pro Ala Ala Lys Lys Lys Leu Asp 
1               5               


<210>  4
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIV NES

<400>  4

Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu 
1               5                   10      


<210>  5
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  SV40 NLS extended

<400>  5

Pro Pro Lys Lys Lys Arg Lys Val Glu Asp 
1               5                   10  


<210>  6
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  c-myc NLS

<400>  6

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  7
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  nucleoplasmin NLS

<400>  7

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  8
<211>  72
<212>  PRT
<213>  Murid gammaherpesvirus 4

<400>  8

Gly Cys Cys Ala Gly Gly Gly Thr Ala Gly Cys Thr Cys Ala Ala Thr 
1               5                   10                  15      


Thr Gly Gly Thr Ala Gly Ala Gly Cys Ala Thr Cys Ala Gly Gly Cys 
            20                  25                  30          


Thr Ala Gly Thr Ala Thr Cys Cys Thr Gly Thr Cys Gly Gly Thr Thr 
        35                  40                  45              


Cys Cys Gly Gly Thr Thr Cys Ala Ala Gly Thr Cys Cys Gly Gly Gly 
    50                  55                  60                  


Cys Cys Cys Thr Gly Gly Thr Thr 
65                  70          


<210>  9
<211>  84
<212>  PRT
<213>  Hepatitis delta virus

<400>  9

Gly Gly Cys Cys Gly Gly Cys Ala Thr Gly Gly Thr Cys Cys Cys Ala 
1               5                   10                  15      


Gly Cys Cys Thr Cys Cys Thr Cys Gly Cys Thr Gly Gly Cys Gly Cys 
            20                  25                  30          


Cys Gly Gly Cys Thr Gly Gly Gly Cys Ala Ala Cys Ala Thr Thr Cys 
        35                  40                  45              


Cys Gly Ala Gly Gly Gly Gly Ala Cys Cys Gly Thr Cys Cys Cys Cys 
    50                  55                  60                  


Thr Cys Gly Gly Thr Ala Ala Thr Gly Gly Cys Gly Ala Ala Thr Gly 
65                  70                  75                  80  


Gly Gly Ala Cys 
                


