﻿                         序列表

<110>  远大赛威信生命科学（南京）有限公司

<120>  诺如病毒病毒样颗粒、免疫组合物或试剂盒及其用途

<130>   EIC21310029P

<150>  202011606203.7
<151>  2020-12-30

<150>  202011606268.1
<151>  2020-12-30

<160>  12

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  530
<212>  PRT
<213>  诺如病毒(Norovirus)

<400>  1
Met Met Met Ala Ser Lys Asp Ala Thr Ser Ser Val Asp Gly Ala Ser 
1               5                   10                  15      
Gly Ala Gly Gln Leu Val Pro Glu Val Asn Ala Ser Asp Pro Leu Ala 
            20                  25                  30          
Met Asp Pro Val Ala Gly Ser Ser Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              
Val Asn Pro Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  
Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  
Phe Asp Leu Ser Leu Gly Pro His Leu Asn Pro Phe Leu Leu His Leu 
                85                  90                  95      
Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Met 
            100                 105                 110         
Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Val Ser Cys Ile 
        115                 120                 125             
Pro Pro Gly Phe Gly Ser His Asn Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 
Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Ile Glu Val 
145                 150                 155                 160 
Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Arg Asn 
                165                 170                 175     
Gln Gln Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Thr 
            180                 185                 190         
Gly Gly Gly Thr Gly Asp Ser Phe Val Val Ala Gly Arg Val Met Thr 
        195                 200                 205             
Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val 
    210                 215                 220                 
Glu Gln Lys Thr Arg Pro Phe Thr Leu Pro Asn Leu Pro Leu Ser Ser 
225                 230                 235                 240 
Leu Ser Asn Ser Arg Ala Pro Leu Pro Ile Ser Ser Met Gly Ile Ser 
                245                 250                 255     
Pro Asp Asn Val Gln Ser Val Gln Phe Gln Asn Gly Arg Cys Thr Leu 
            260                 265                 270         
Asp Gly Arg Leu Val Gly Thr Thr Pro Val Ser Leu Ser His Val Ala 
        275                 280                 285             
Lys Ile Arg Gly Thr Ser Asn Gly Thr Val Ile Asn Leu Thr Glu Leu 
    290                 295                 300                 
Asp Gly Thr Pro Phe His Pro Phe Glu Gly Pro Ala Pro Ile Gly Phe 
305                 310                 315                 320 
Pro Asp Leu Gly Gly Cys Asp Trp His Ile Asn Met Thr Gln Phe Gly 
                325                 330                 335     
His Ser Ser Gln Thr Gln Tyr Asp Val Asp Thr Thr Pro Asp Thr Phe 
            340                 345                 350         
Val Pro His Leu Gly Ser Ile Gln Ala Asn Gly Ile Gly Ser Gly Asn 
        355                 360                 365             
Tyr Val Gly Val Leu Ser Trp Ile Ser Pro Pro Ser His Pro Ser Gly 
    370                 375                 380                 
Ser Gln Val Asp Leu Trp Lys Ile Pro Asn Tyr Gly Ser Ser Ile Thr 
385                 390                 395                 400 
Glu Ala Thr His Leu Ala Pro Ser Val Tyr Pro Pro Gly Phe Gly Glu 
                405                 410                 415     
Val Leu Val Phe Phe Met Ser Lys Met Pro Gly Pro Gly Ala Tyr Asn 
            420                 425                 430         
Leu Pro Cys Leu Leu Pro Gln Glu Tyr Ile Ser His Leu Ala Ser Glu 
        435                 440                 445             
Gln Ala Pro Thr Val Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro 
    450                 455                 460                 
Asp Thr Gly Arg Asn Leu Gly Glu Phe Lys Ala Tyr Pro Asp Gly Phe 
465                 470                 475                 480 
Leu Thr Cys Val Pro Asn Gly Ala Ser Ser Gly Pro Gln Gln Leu Pro 
                485                 490                 495     
Ile Asn Gly Val Phe Val Phe Val Ser Trp Val Ser Arg Phe Tyr Gln 
            500                 505                 510         
Leu Lys Pro Val Gly Thr Ala Ser Ser Ala Arg Gly Arg Leu Gly Leu 
        515                 520                 525             
Arg Arg 
    530 

<210>  2
<211>  542
<212>  PRT
<213>  诺如病毒(Norovirus)

<400>  2
Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Thr Asp Gly Ala Ala 
1               5                   10                  15      
Gly Leu Val Pro Glu Ser Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          
Ala Gly Ala Ala Leu Ala Ala Pro Val Thr Gly Gln Thr Asn Ile Ile 
        35                  40                  45              
Asp Pro Trp Ile Arg Ala Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  
Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  
Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      
Asn Gly Tyr Ala Gly Gly Met Glu Val Gln Val Met Leu Ala Gly Asn 
            100                 105                 110         
Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             
Pro Val Glu Asn Leu Ser Pro Gln Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 
Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 
Val Arg Asn Asn Phe Phe His Tyr Asn Gln Lys Asp Asp Pro Lys Met 
                165                 170                 175     
Arg Ile Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         
Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             
Asp Phe Asp Phe Thr Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 
Lys Pro Phe Thr Leu Pro Ile Leu Thr Leu Gly Glu Leu Ser Asn Ser 
225                 230                 235                 240 
Arg Phe Pro Val Ser Ile Asp Gln Met Tyr Thr Ser Pro Asn Glu Ile 
                245                 250                 255     
Ile Ser Val Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         
Gln Gly Thr Thr Gln Leu Gln Val Ser Gly Ile Cys Ala Phe Lys Gly 
        275                 280                 285             
Glu Val Thr Ala His Leu His Asp Asn Asp His Leu Tyr Asn Val Thr 
    290                 295                 300                 
Ile Thr Asn Leu Asn Gly Ser Pro Phe Asp Pro Ser Glu Asp Ile Pro 
305                 310                 315                 320 
Ala Pro Leu Gly Val Pro Asp Phe Gln Gly Arg Val Phe Gly Ile Ile 
                325                 330                 335     
Ser Gln Arg Asp Lys His Asn Ser Pro Gly His Asn Glu Pro Ala Asn 
            340                 345                 350         
Arg Gly His Asp Ala Val Val Pro Thr Tyr Thr Ala Gln Tyr Thr Pro 
        355                 360                 365             
Lys Leu Gly Gln Ile Gln Ile Gly Thr Trp Gln Thr Asp Asp Leu Thr 
    370                 375                 380                 
Val Asn Gln Pro Val Lys Phe Thr Pro Val Gly Leu Asn Asp Thr Glu 
385                 390                 395                 400 
His Phe Asn Gln Trp Val Val Pro Arg Tyr Ala Gly Ala Leu Asn Leu 
                405                 410                 415     
Asn Thr Asn Leu Ala Pro Ser Val Ala Pro Val Phe Pro Gly Glu Arg 
            420                 425                 430         
Leu Leu Phe Phe Arg Ser Tyr Ile Pro Leu Lys Gly Gly Tyr Gly Asn 
        435                 440                 445             
Pro Ala Ile Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
    450                 455                 460                 
Gln Glu Ala Ala Pro Ser Met Ser Glu Val Ala Leu Val Arg Tyr Ile 
465                 470                 475                 480 
Asn Pro Asp Thr Gly Arg Ala Leu Phe Glu Ala Lys Leu His Arg Ala 
                485                 490                 495     
Gly Phe Met Thr Val Ser Ser Asn Thr Ser Ala Pro Val Val Val Pro 
            500                 505                 510         
Ala Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser 
        515                 520                 525             
Leu Ala Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Val Gln 
    530                 535                 540         

<210>  3
<211>  548
<212>  PRT
<213>  诺如病毒(Norovirus)

<400>  3
Met Lys Met Ala Ser Asn Asp Ala Thr Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      
Gly Leu Val Pro Glu Ile Asn Asn Glu Ala Met Ala Leu Asp Pro Val 
            20                  25                  30          
Ala Gly Ala Ala Ile Ala Ala Pro Leu Thr Gly Gln Gln Asn Ile Ile 
        35                  40                  45              
Asp Pro Trp Ile Met Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  
Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  
Leu Gly Pro Glu Ile Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      
Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Val Leu Ala Gly Asn 
            100                 105                 110         
Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Ile Pro Pro Asn Phe 
        115                 120                 125             
Pro Ile Asp Asn Leu Ser Ala Ala Gln Ile Thr Met Cys Pro His Val 
    130                 135                 140                 
Ile Val Asp Val Arg Gln Leu Glu Pro Val Asn Leu Pro Met Pro Asp 
145                 150                 155                 160 
Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gly Ser Asp Ser Arg Leu 
                165                 170                 175     
Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ser Gly 
            180                 185                 190         
Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             
Glu Phe Ser Phe Asn Phe Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 
Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Ser Glu Met Ser Asn Ser 
225                 230                 235                 240 
Arg Phe Pro Val Pro Ile Asp Ser Leu His Thr Ser Pro Thr Glu Asn 
                245                 250                 255     
Ile Val Val Gln Cys Gln Asn Gly Arg Val Thr Leu Asp Gly Glu Leu 
            260                 265                 270         
Met Gly Thr Thr Gln Leu Leu Pro Ser Gln Ile Cys Ala Phe Arg Gly 
        275                 280                 285             
Val Leu Thr Arg Ser Thr Ser Arg Ala Ser Asp Gln Ala Asp Thr Ala 
    290                 295                 300                 
Thr Pro Arg Leu Phe Asn Tyr Tyr Trp His Ile Gln Leu Asp Asn Leu 
305                 310                 315                 320 
Asn Gly Thr Pro Tyr Asp Pro Ala Glu Asp Ile Pro Gly Pro Leu Gly 
                325                 330                 335     
Thr Pro Asp Phe Arg Gly Lys Val Phe Gly Val Ala Ser Gln Arg Asn 
            340                 345                 350         
Pro Asp Ser Thr Thr Arg Ala His Glu Ala Lys Val Asp Thr Thr Ala 
        355                 360                 365             
Gly Arg Phe Thr Pro Lys Leu Gly Ser Leu Glu Ile Ser Thr Glu Ser 
    370                 375                 380                 
Gly Asp Phe Asp Gln Asn Gln Pro Thr Arg Phe Thr Pro Val Gly Ile 
385                 390                 395                 400 
Gly Val Asp His Glu Ser Asp Phe Gln Gln Trp Ser Leu Pro Asp Tyr 
                405                 410                 415     
Ser Gly Gln Phe Thr His Asn Met Asn Leu Ala Pro Ala Val Ala Pro 
            420                 425                 430         
Asn Phe Pro Gly Glu Gln Leu Leu Phe Phe Arg Ser Gln Leu Pro Ser 
        435                 440                 445             
Ser Gly Gly Arg Ser Asn Gly Ile Leu Asp Cys Leu Val Pro Gln Glu 
    450                 455                 460                 
Trp Val Gln His Phe Tyr Gln Glu Ser Ala Pro Ala Gln Thr Gln Val 
465                 470                 475                 480 
Ala Leu Val Arg Tyr Val Asn Pro Asp Thr Gly Arg Val Leu Phe Glu 
                485                 490                 495     
Ala Lys Leu His Lys Leu Gly Phe Met Thr Ile Ala Lys Asn Gly Asp 
            500                 505                 510         
Ser Pro Ile Thr Val Pro Pro Asn Gly Tyr Phe Arg Phe Glu Ser Trp 
        515                 520                 525             
Val Asn Pro Phe Tyr Thr Leu Ala Pro Met Gly Thr Gly Asn Gly Arg 
    530                 535                 540                 
Arg Arg Val Gln 
545             

<210>  4
<211>  540
<212>  PRT
<213>  诺如病毒(Norovirus)

<400>  4
Met Lys Met Ala Ser Ser Asp Ala Asn Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      
Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          
Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              
Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  
Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  
Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      
Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         
Ala Phe Thr Ala Gly Lys Val Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             
Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 
Val Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 
Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Pro Thr Ile 
                165                 170                 175     
Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         
Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             
Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 
Lys Pro Phe Ser Val Pro Val Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 
Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     
Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         
Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             
Asp Val Thr His Ile Thr Gly Ser Arg Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 
Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 
Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     
Thr Thr Arg Thr Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Tyr 
            340                 345                 350         
Thr Gly Ser Ala Asp Phe Ala Pro Lys Leu Gly Arg Val Gln Phe Glu 
        355                 360                 365             
Thr Asp Thr Asp His Asp Phe Glu Ala Asn Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 
Pro Val Gly Val Ile Gln Asp Gly Ser Thr Thr His Arg Asn Glu Pro 
385                 390                 395                 400 
Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Thr His Asn Val 
                405                 410                 415     
His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         
Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asp 
        435                 440                 445             
Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln Tyr Phe Tyr Gln Glu 
    450                 455                 460                 
Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 
Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     
Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         
Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             
Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Val 
    530                 535                 540 

<210>  5
<211>  547
<212>  PRT
<213>  诺如病毒(Norovirus)

<400>  5
Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      
Asn Leu Val Pro Glu Ala Thr Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          
Val Gly Ala Ser Ile Ala Ala Pro Val Val Gly Gln Gln Asn Ile Ile 
        35                  40                  45              
Asp Pro Trp Ile Arg Glu Asn Phe Val Gln Ala Pro Gln Gly Glu Phe 
    50                  55                  60                  
Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Met Leu Leu Asn Leu Glu 
65                  70                  75                  80  
Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ser His Leu Ser Arg Met Tyr 
                85                  90                  95      
Asn Gly Tyr Ala Gly Gly Met Gln Val Gln Val Val Leu Ala Gly Asn 
            100                 105                 110         
Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             
Pro Val Glu Asn Ile Ser Ala Ala Gln Ile Thr Met Cys Pro His Val 
    130                 135                 140                 
Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 
Ile Arg Asn Arg Phe Phe His Tyr Asn Gln Glu Asn Thr Pro Arg Met 
                165                 170                 175     
Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Ser Gly Glu 
            180                 185                 190         
Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ala Pro Asp 
        195                 200                 205             
Phe Glu Phe Thr Phe Leu Val Pro Pro Thr Val Glu Ser Lys Thr Lys 
    210                 215                 220                 
Pro Phe Thr Leu Pro Ile Leu Thr Leu Gly Glu Leu Ser Asn Ser Arg 
225                 230                 235                 240 
Phe Pro Ala Pro Ile Asp Met Leu Tyr Thr Asp Pro Asn Glu Ala Ile 
                245                 250                 255     
Val Val Gln Pro Gln Asn Gly Arg Cys Thr Leu Asp Gly Thr Leu Gln 
            260                 265                 270         
Gly Thr Thr Gln Leu Val Pro Thr Gln Ile Cys Ser Phe Arg Gly Thr 
        275                 280                 285             
Leu Val Ser Gln Thr Ser Arg Ser Ala Asp Ser Thr Asp Ser Ala Pro 
    290                 295                 300                 
Arg Val Arg Ser His Pro Leu His Val Gln Leu Lys Asn Leu Asp Gly 
305                 310                 315                 320 
Thr Pro Tyr Asp Pro Thr Asp Glu Val Pro Ala Val Leu Gly Ala Ile 
                325                 330                 335     
Asp Phe Lys Gly Thr Val Phe Gly Val Ala Ser Gln Arg Asn Thr Thr 
            340                 345                 350         
Gly Asn Ser Ile Gly Ala Thr Arg Ala His Glu Val His Ile Asp Thr 
        355                 360                 365             
Thr Asn Pro Arg Tyr Thr Pro Lys Leu Gly Ser Val Leu Met Tyr Ser 
    370                 375                 380                 
Glu Ser Asn Asp Phe Asp Asp Gly Gln Pro Thr Arg Phe Thr Pro Ile 
385                 390                 395                 400 
Gly Met Gly Ala Asp Asp Trp His Gln Trp Glu Leu Pro Glu Tyr Ser 
                405                 410                 415     
Gly His Leu Thr Leu Asn Met Asn Leu Ala Pro Ala Leu Ala Pro Ala 
            420                 425                 430         
Phe Pro Gly Glu Arg Ile Leu Phe Phe Arg Ser Val Val Pro Ser Ala 
        435                 440                 445             
Gly Gly Tyr Gly Ser Gly His Ile Asp Cys Leu Ile Pro Gln Glu Trp 
    450                 455                 460                 
Val Gln His Phe Tyr Gln Glu Ala Ala Pro Ser Gln Ser Ala Val Ala 
465                 470                 475                 480 
Leu Ile Arg Tyr Val Asn Pro Asp Thr Gly Arg Asn Ile Phe Glu Ala 
                485                 490                 495     
Lys Leu His Arg Glu Gly Phe Ile Thr Val Ala Asn Ser Gly Asn Asn 
            500                 505                 510         
Pro Ile Val Val Pro Pro Asn Gly Tyr Phe Arg Phe Glu Ala Trp Val 
        515                 520                 525             
Asn Gln Phe Tyr Thr Leu Thr Pro Met Gly Thr Gly Gln Gly Arg Arg 
    530                 535                 540                 
Arg Val Gln 
545         

<210>  6
<211>  540
<212>  PRT
<213>  诺如病毒(Norovirus)

<400>  6
Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      
Gly Leu Val Pro Glu Ile Asn Asn Glu Val Met Pro Leu Glu Pro Val 
            20                  25                  30          
Ala Gly Ala Ser Leu Ala Thr Pro Val Ala Gly Gln His Asn Ile Ile 
        35                  40                  45              
Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Ala Gly Glu Phe 
    50                  55                  60                  
Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Leu Asp Leu Glu 
65                  70                  75                  80  
Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      
Asn Gly His Ala Gly Gly Met Glu Val Gln Ile Val Leu Ala Gly Asn 
            100                 105                 110         
Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Ile Pro Pro Gly Phe 
        115                 120                 125             
Pro Tyr Glu Asn Leu Ser Pro Ser Gln Ile Thr Met Cys Pro His Val 
    130                 135                 140                 
Ile Ile Asp Val Arg Gln Leu Glu Pro Val Leu Leu Pro Met Pro Asp 
145                 150                 155                 160 
Ile Arg Asn Asn Phe Phe His Tyr Asn Gln Ser Asn Asp Pro Lys Leu 
                165                 170                 175     
Arg Leu Leu Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ser Gly 
            180                 185                 190         
Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Lys Pro Ser Pro 
        195                 200                 205             
Asp Phe Glu Phe Thr Phe Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 
Lys Gln Phe Thr Leu Pro Ile Leu Lys Ile Ser Glu Met Thr Asn Ser 
225                 230                 235                 240 
Arg Phe Pro Val Pro Val Glu Met Met Tyr Thr Ala Arg Asn Glu Asn 
                245                 250                 255     
Gln Val Val Gln Pro Gln Asn Gly Arg Val Thr Leu Asp Gly Glu Leu 
            260                 265                 270         
Leu Gly Thr Thr Pro Leu Leu Ala Val Asn Ile Cys Lys Phe Lys Gly 
        275                 280                 285             
Glu Val Ile Ala Lys Asn Gly Asp Val Arg Ser Tyr Arg Met Asp Met 
    290                 295                 300                 
Glu Ile Thr Asn Thr Asp Gly Thr Pro Ile Asp Pro Thr Glu Asp Thr 
305                 310                 315                 320 
Pro Gly Pro Ile Gly Ser Pro Asp Phe Gln Gly Ile Leu Phe Gly Val 
                325                 330                 335     
Ala Ser Gln Arg Asn Lys Asn Glu Gln Asn Pro Ala Thr Arg Ala His 
            340                 345                 350         
Glu Ala Asn Ile Asn Thr Gly Gly Asp Gln Tyr Ala Pro Lys Leu Ala 
        355                 360                 365             
Gln Val Lys Phe Phe Ser Glu Ser Gln Asp Phe Glu Val His Gln Pro 
    370                 375                 380                 
Thr Val Phe Thr Pro Val Gly Val Val Gly Asp Ser Ser His Pro Phe 
385                 390                 395                 400 
Arg Gln Trp Val Leu Pro Arg Tyr Gly Gly His Leu Thr Asn Asn Thr 
                405                 410                 415     
His Leu Ala Pro Ala Val Ala Pro Leu Phe Pro Gly Glu Gln Ile Leu 
            420                 425                 430         
Phe Phe Arg Ser Gln Ile Pro Ser Ser Gly Gly His Glu Ser Gly Tyr 
        435                 440                 445             
Val Asp Cys Leu Val Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu 
    450                 455                 460                 
Ala Ala Thr Ala Gln Ser Glu Val Ala Leu Ile Arg Phe Ile Asn Pro 
465                 470                 475                 480 
Asp Thr Gly Arg Val Leu Phe Glu Ala Lys Leu His Lys Gln Gly Phe 
                485                 490                 495     
Ile Thr Val Ala His Thr Gly Asp Asn Pro Ile Val Met Pro Pro Asn 
            500                 505                 510         
Gly Tyr Phe Arg Phe Glu Ala Trp Val Asn Gln Phe Tyr Ser Leu Ala 
        515                 520                 525             
Pro Val Gly Thr Gly Asn Gly Arg Arg Arg Ile Gln 
    530                 535                 540 

<210>  7
<211>  535
<212>  PRT
<213>  诺如病毒(Norovirus)

<400>  7
Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      
Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          
Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              
Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  
Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  
Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      
Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         
Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             
Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 
Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 
Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     
Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         
Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             
Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 
Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Gly Glu Leu Thr Asn Ser 
225                 230                 235                 240 
Arg Phe Pro Val Pro Ile Asp Glu Leu Tyr Thr Ser Pro Asn Glu Ser 
                245                 250                 255     
Leu Val Val Gln Pro Gln Asn Gly Arg Cys Ala Leu Asp Gly Glu Leu 
            260                 265                 270         
Gln Gly Thr Thr Gln Leu Leu Pro Thr Ala Ile Cys Ser Phe Arg Gly 
        275                 280                 285             
Arg Ile Asn Gln Lys Val Ser Gly Glu Asn His Val Trp Asn Met Gln 
    290                 295                 300                 
Ile Thr Asn Ile Asn Gly Thr Pro Phe Asp Pro Thr Glu Asp Val Pro 
305                 310                 315                 320 
Ala Pro Leu Gly Thr Pro Asp Phe Ser Gly Lys Leu Phe Gly Val Leu 
                325                 330                 335     
Ser Gln Arg Asp His Asp Asn Ala Cys Arg Ser His Asp Ala Val Ile 
            340                 345                 350         
Ala Thr Asn Ser Ala Lys Phe Thr Pro Lys Leu Gly Ala Ile Gln Ile 
        355                 360                 365             
Gly Thr Trp Glu Gln Asp Asp Val His Ile Asn Gln Pro Thr Lys Phe 
    370                 375                 380                 
Thr Pro Val Gly Leu Phe Glu Ser Glu Gly Phe Asn Gln Trp Thr Leu 
385                 390                 395                 400 
Pro Asn Tyr Ser Gly Ala Leu Thr Leu Asn Met Gly Leu Ala Pro Pro 
                405                 410                 415     
Val Ala Pro Thr Phe Pro Gly Glu Gln Ile Leu Phe Phe Arg Ser His 
            420                 425                 430         
Ile Pro Leu Lys Gly Gly Val Ala Asp Pro Val Ile Asp Cys Leu Leu 
        435                 440                 445             
Pro Gln Glu Trp Ile Gln His Leu Tyr Gln Glu Ser Ala Pro Ser Gln 
    450                 455                 460                 
Thr Asp Val Ala Leu Ile Arg Phe Thr Asn Pro Asp Thr Gly Arg Val 
465                 470                 475                 480 
Leu Phe Glu Ala Lys Leu His Arg Ser Gly Tyr Ile Thr Val Ala Asn 
                485                 490                 495     
Thr Gly Ser Arg Pro Ile Val Val Pro Ala Asn Gly Tyr Phe Arg Phe 
            500                 505                 510         
Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala Pro Met Gly Thr Gly 
        515                 520                 525             
Asn Gly Arg Arg Arg Val Gln 
    530                 535 

<210>  8
<211>  540
<212>  PRT
<213>  诺如病毒(Norovirus)

<400>  8
Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      
Gly Leu Val Pro Glu Gly Asn Asn Glu Thr Leu Pro Leu Glu Pro Val 
            20                  25                  30          
Ala Gly Ala Ala Ile Ala Ala Pro Val Thr Gly Gln Asn Asn Ile Ile 
        35                  40                  45              
Asp Pro Trp Ile Arg Thr Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  
Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Leu Asn Leu Glu 
65                  70                  75                  80  
Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      
Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         
Ala Phe Thr Ala Gly Lys Ile Leu Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             
Pro Val Glu Phe Leu Ser Pro Ala Gln Ile Thr Met Leu Pro His Leu 
    130                 135                 140                 
Ile Val Asp Val Arg Thr Leu Glu Pro Ile Met Ile Pro Leu Pro Asp 
145                 150                 155                 160 
Val Arg Asn Thr Phe Phe His Tyr Ser Asn Gln Pro Asn Ser Arg Met 
                165                 170                 175     
Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         
Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Thr Pro 
        195                 200                 205             
Asp Phe Glu Phe Thr Tyr Leu Val Pro Pro Ser Val Glu Ser Lys Thr 
    210                 215                 220                 
Lys Pro Phe Ser Leu Pro Ile Leu Thr Leu Ser Glu Leu Thr Asn Ser 
225                 230                 235                 240 
Arg Phe Pro Val Pro Ile Asp Ser Leu Phe Thr Ala Gln Asn Asn Val 
                245                 250                 255     
Leu Gln Val Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         
Gln Gly Thr Thr Gln Leu Leu Pro Ser Gly Ile Cys Ala Phe Arg Gly 
        275                 280                 285             
Arg Val Thr Ala Gln Ile Asn Gln Arg Asp Arg Trp His Met Gln Leu 
    290                 295                 300                 
Gln Asn Leu Asn Gly Thr Thr Tyr Asp Pro Thr Asp Asp Val Pro Ala 
305                 310                 315                 320 
Pro Leu Gly Thr Pro Asp Phe Lys Gly Val Val Phe Gly Met Val Ser 
                325                 330                 335     
Gln Arg Asn Val Gly Asn Asp Ala Pro Gly Ser Thr Arg Ala Gln Gln 
            340                 345                 350         
Ala Trp Val Ser Thr Tyr Ser Pro Gln Phe Val Pro Lys Leu Gly Ser 
        355                 360                 365             
Val Asn Leu Arg Ile Ser Asp Asn Asp Asp Phe Gln Phe Gln Pro Thr 
    370                 375                 380                 
Lys Phe Thr Pro Val Gly Val Asn Asp Asp Asp Asp Gly His Pro Phe 
385                 390                 395                 400 
Arg Gln Trp Glu Leu Pro Asn Tyr Ser Gly Glu Leu Thr Leu Asn Met 
                405                 410                 415     
Asn Leu Ala Pro Pro Val Ala Pro Asn Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         
Phe Phe Arg Ser Phe Val Pro Cys Ser Gly Gly Tyr Asn Gln Gly Ile 
        435                 440                 445             
Ile Asp Cys Leu Ile Pro Gln Glu Trp Ile Gln His Phe Tyr Gln Glu 
    450                 455                 460                 
Ser Ala Pro Ser Gln Ser Asp Val Ala Leu Ile Arg Tyr Val Asn Pro 
465                 470                 475                 480 
Asp Thr Gly Arg Thr Leu Phe Glu Ala Lys Leu His Arg Ser Gly Tyr 
                485                 490                 495     
Ile Thr Val Ala His Ser Gly Asp Tyr Pro Leu Val Val Pro Ala Asn 
            500                 505                 510         
Gly His Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala 
        515                 520                 525             
Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Ala Gln 
    530                 535                 540 

<210>  9
<211>  21
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  9
tcgttcgttc gttcgttcgt t                                                  21

<210>  10
<211>  25
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  10
tcgttcgttc gttcgttcgt tcgtt                                              25

<210>  11
<211>  21
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  11
tcgtcgtcgt cgtcgtcgtc g                                                  21

<210>  12
<211>  540
<212>  PRT
<213>  诺如病毒(Norovirus)

<400>  12
Met Lys Met Ala Ser Ser Asp Ala Asn Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      
Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          
Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              
Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  
Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  
Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      
Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         
Ala Phe Thr Ala Gly Lys Val Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             
Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 
Val Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 
Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Pro Thr Ile 
                165                 170                 175     
Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         
Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             
Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 
Lys Pro Phe Ser Val Pro Val Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 
Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     
Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         
Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             
Asp Val Thr His Ile Thr Gly Ser Arg Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 
Ser Gln Asn Trp Ser Asn Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 
Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     
Thr Thr Arg Thr Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Tyr 
            340                 345                 350         
Thr Gly Ser Ala Asp Phe Ala Pro Lys Leu Gly Arg Val Gln Phe Glu 
        355                 360                 365             
Thr Asp Thr Asp Arg Asp Phe Glu Ala Asn Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 
Pro Val Gly Val Ile Gln Asp Gly Ser Thr Thr His Arg Asn Glu Pro 
385                 390                 395                 400 
Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Thr Pro Asn Val 
                405                 410                 415     
His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         
Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asp 
        435                 440                 445             
Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln Tyr Phe Tyr Gln Glu 
    450                 455                 460                 
Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 
Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     
Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         
Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             
Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Leu 
    530                 535                 540 

