                         б

<110>  ҽҩƼ޹˾
       ҽƿƼ޹˾

<120>  һԽBCMAĿ弰Ӧ

<130>  AJ7552PCT2104

<160>  56

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  10
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  UNSURE
<222>  (5)..(5)
<223>  Ser  Thr  Arg


<220>
<221>  UNSURE
<222>  (6)..(6)
<223>  Arg  Ser  His


<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  VH-CDR1


<400>  1
Gly Tyr Thr Phe Xaa Xaa Tyr Ser Met Asn 
1               5                   10  

<210>  3
<211>  17
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  UNSURE
<222>  (5)..(5)
<223>  Gly  Glu  Arg


<220>
<221>  UNSURE
<222>  (8)..(8)
<223>  Ala  Thr  Val


<220>
<221>  UNSURE
<222>  (10)..(10)
<223>  Ile  Asn


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  VH-CDR2


<400>  3
Arg Ile Asn Thr Xaa Ser Gly Xaa Pro Xaa Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      
Gly 
    

<210>  3
<211>  10
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  UNSURE
<222>  (5)..(5)
<223>  Asn  Leu


<220>
<221>  UNSURE
<222>  (10)..(10)
<223>  His  Tyr  Phe


<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  VH-CDR3


<400>  3
Ser Asn Asp Tyr Xaa Tyr Ser Leu Asp Xaa 
1               5                   10  

<210>  4
<211>  15
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  UNSURE
<222>  (4)..(4)
<223>  Arg  Glu


<220>
<221>  UNSURE
<222>  (7)..(7)
<223>  Thr  Ser


<220>
<221>  UNSURE
<222>  (8)..(8)
<223>  Ile  Val


<220>
<221>  UNSURE
<222>  (9)..(9)
<223>  Ala  Leu


<220>
<221>  UNSURE
<222>  (11)..(11)
<223>  Ser  Asn


<220>
<221>  UNSURE
<222>  (12)..(12)
<223>  Pro  His


<220>
<221>  UNSURE
<222>  (13)..(13)
<223>  Ile  Leu


<220>
<221>  UNSURE
<222>  (14)..(14)
<223>  Ile  Val


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  VL-CDR1


<400>  4
Arg Ala Ser Xaa Ser Val Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Tyr 
1               5                   10                  15  

<210>  5
<211>  7
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(7)
<223>  VL-CDR2


<400>  5
Leu Ala Ser Asn Val Gln Thr 
1               5           

<210>  6
<211>  9
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  UNSURE
<222>  (1)..(1)
<223>  Leu  Phe


<220>
<221>  UNSURE
<222>  (5)..(5)
<223>  Thr  Ser


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  VL-CDR3


<400>  6
Xaa Gln Ser Arg Xaa Ile Pro Arg Thr 
1               5                   

<210>  7
<211>  10
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  VH-CDR1


<400>  7
Gly Tyr Thr Phe Ser Arg Tyr Ser Met Asn 
1               5                   10  

<210>  8
<211>  10
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  VH-CDR1


<400>  8
Gly Tyr Thr Phe Thr Ser Tyr Ser Met Asn 
1               5                   10  

<210>  9
<211>  10
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  VH-CDR1


<400>  9
Gly Tyr Thr Phe Arg His Tyr Ser Met Asn 
1               5                   10  

<210>  10
<211>  17
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  VH-CDR2


<400>  10
Arg Ile Asn Thr Gly Ser Gly Ala Pro Ile Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      
Gly 
    

<210>  11
<211>  17
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  VH-CDR2


<400>  11
Arg Ile Asn Thr Glu Ser Gly Ala Pro Asn Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      
Gly 
    

<210>  12
<211>  17
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  VH-CDR2


<400>  12
Arg Ile Asn Thr Arg Ser Gly Thr Pro Asn Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      
Gly 
    

<210>  13
<211>  17
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  VH-CDR2


<400>  13
Arg Ile Asn Thr Glu Ser Gly Val Pro Ile Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      
Gly 
    

<210>  14
<211>  10
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  VH-CDR3


<400>  14
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His 
1               5                   10  

<210>  15
<211>  10
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  VH-CDR3


<400>  15
Ser Asn Asp Tyr Leu Tyr Ser Leu Asp Tyr 
1               5                   10  

<210>  16
<211>  10
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(10)
<223>  VH-CDR3


<400>  16
Ser Asn Asp Tyr Leu Tyr Ser Leu Asp Phe 
1               5                   10  

<210>  17
<211>  15
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  VL-CDR1


<400>  17
Arg Ala Ser Arg Ser Val Thr Ile Leu Gly Asn Pro Ile Val Tyr 
1               5                   10                  15  

<210>  18
<211>  15
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  VL-CDR1


<400>  18
Arg Ala Ser Arg Ser Val Ser Val Ala Gly Asn His Ile Val Tyr 
1               5                   10                  15  

<210>  19
<211>  15
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  VL-CDR1


<400>  19
Arg Ala Ser Glu Ser Val Thr Ile Leu Gly Ser His Leu Ile Tyr 
1               5                   10                  15  

<210>  20
<211>  7
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(7)
<223>  VL-CDR2


<400>  20
Leu Ala Ser Asn Val Gln Thr 
1               5           

<210>  21
<211>  9
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  VL-CDR3


<400>  21
Leu Gln Ser Arg Thr Ile Pro Arg Thr 
1               5                   

<210>  22
<211>  9
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  VL-CDR3


<400>  22
Phe Gln Ser Arg Ser Ile Pro Arg Thr 
1               5                   

<210>  23
<211>  117
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(117)
<223>  VH


<400>  23
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Gly Ser Gly Ala Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Ile Phe Ser Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Val Ile Asn Asn Leu Lys Ser Glu Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  24
<211>  117
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(117)
<223>  VH


<400>  24
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Gly Ser Gly Ala Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Ser Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Val Ile Asn Asn Leu Lys Ser Glu Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  25
<211>  117
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(117)
<223>  VH


<400>  25
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Gly Ser Gly Ala Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Val Leu Asn Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  26
<211>  117
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(117)
<223>  VH


<400>  26
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg His Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Glu Ser Gly Val Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Val Leu Asn Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Leu Tyr Ser Leu Asp Phe Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  27
<211>  117
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(117)
<223>  VH


<400>  27
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Glu Ser Gly Ala Pro Asn Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Glu Ile Asn Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Leu Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  28
<211>  117
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(117)
<223>  VH


<400>  28
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Gly Ser Gly Ala Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Ile Phe Ser Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  29
<211>  117
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(117)
<223>  VH


<400>  29
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Arg Ser Gly Thr Pro Asn Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Asn Leu Lys Ser Glu Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  30
<211>  117
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(117)
<223>  VH


<400>  30
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Gly Ser Gly Ala Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Val Leu Asn Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  31
<211>  117
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(117)
<223>  VH


<400>  31
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg His Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Glu Ser Gly Val Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Val Leu Asn Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Leu Tyr Ser Leu Asp Phe Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  32
<211>  117
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(117)
<223>  VH


<400>  32
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Glu Ser Gly Ala Pro Asn Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Thr Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Glu Ile Asn Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Leu Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  33
<211>  111
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(111)
<223>  VL


<400>  33
Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Arg Ser Val Thr Ile Leu 
            20                  25                  30          
Gly Asn Pro Ile Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Val Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      
Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  34
<211>  111
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(111)
<223>  VL


<400>  34
Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Arg Ser Val Thr Ile Leu 
            20                  25                  30          
Gly Asn Pro Ile Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Val Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Phe Gln Ser Arg 
                85                  90                  95      
Ser Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  35
<211>  111
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(111)
<223>  VL


<400>  35
Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Thr Ile Leu 
            20                  25                  30          
Gly Asn Pro Ile Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Val Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Leu Glu Glu Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      
Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  36
<211>  111
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(111)
<223>  VL


<400>  36
Glu Ile Val Leu Thr Gln Ser Pro Pro Thr Leu Ala Met Ser Leu Gly 
1               5                   10                  15      
Lys Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Thr Ile Leu 
            20                  25                  30          
Gly Ser His Leu Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Leu Glu Glu Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      
Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  37
<211>  111
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(111)
<223>  VL


<400>  37
Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Ser Val Ala 
            20                  25                  30          
Gly Asn His Ile Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Val Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      
Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  38
<211>  111
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(111)
<223>  VL


<400>  38
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Arg Ser Val Thr Ile Leu 
            20                  25                  30          
Gly Asn Pro Ile Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Val Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      
Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  39
<211>  111
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(111)
<223>  VL


<400>  39
Glu Ile Val Met Thr Gln Ser Pro Pro Thr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Thr Ile Leu 
            20                  25                  30          
Gly Asn Pro Ile Val Tyr Trp Tyr Gln Gln Lys Ala Pro Lys Pro Pro 
        35                  40                  45              
Val Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Leu Glu Glu Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      
Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  40
<211>  111
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(111)
<223>  111


<400>  40
Glu Ile Val Leu Thr Gln Ser Pro Pro Thr Leu Ala Met Ser Leu Gly 
1               5                   10                  15      
Lys Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Thr Ile Leu 
            20                  25                  30          
Gly Ser His Leu Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Leu Glu Glu Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      
Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     

<210>  41
<211>  111
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(111)

<400>  41
Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Ser Val Ala 
            20                  25                  30          
Gly Asn His Ile Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Val Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      
Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  42
<211>  111
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(111)
<223>  VL


<400>  42
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Arg Ser Val Thr Ile Leu 
            20                  25                  30          
Gly Asn Pro Ile Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Val Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      
Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  43
<211>  111
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(111)
<223>  VL


<400>  43
Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Arg Ser Val Thr Ile Leu 
            20                  25                  30          
Gly Asn Pro Ile Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Val Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      
Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  44
<211>  246
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(246)
<223>  scFv


<400>  44
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Gly Ser Gly Ala Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Ile Phe Ser Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Val Ile Asn Asn Leu Lys Ser Glu Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
        115                 120                 125             
Gly Glu Gly Ser Thr Lys Gly Asp Ile Val Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 
Ser Leu Ser Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
145                 150                 155                 160 
Ser Arg Ser Val Thr Ile Leu Gly Asn Pro Ile Val Tyr Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Pro Pro Val Leu Leu Ile Gln Leu Ala Ser Asn 
            180                 185                 190         
Val Gln Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

<210>  45
<211>  246
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(246)
<223>  scFv


<400>  45
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Gly Ser Gly Ala Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Ser Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Val Ile Asn Asn Leu Lys Ser Glu Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
        115                 120                 125             
Gly Glu Gly Ser Thr Lys Gly Asp Ile Val Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 
Ser Leu Ser Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
145                 150                 155                 160 
Ser Arg Ser Val Thr Ile Leu Gly Asn Pro Ile Val Tyr Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Pro Pro Val Leu Leu Ile Gln Leu Ala Ser Asn 
            180                 185                 190         
Val Gln Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

<210>  46
<211>  246
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(246)
<223>  scFv


<400>  46
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Gly Ser Gly Ala Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Ser Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Val Ile Asn Asn Leu Lys Ser Glu Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
        115                 120                 125             
Gly Glu Gly Ser Thr Lys Gly Asp Ile Val Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 
Ser Leu Ser Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
145                 150                 155                 160 
Ser Arg Ser Val Thr Ile Leu Gly Asn Pro Ile Val Tyr Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Pro Pro Val Leu Leu Ile Gln Leu Ala Ser Asn 
            180                 185                 190         
Val Gln Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Phe Gln Ser Arg Ser Ile Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

<210>  47
<211>  246
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(246)
<223>  scFv


<400>  47
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Gly Ser Gly Ala Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Val Leu Asn Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
        115                 120                 125             
Gly Glu Gly Ser Thr Lys Gly Glu Ile Val Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 
Thr Leu Ser Val Ser Leu Gly Gln Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 
Ser Arg Ser Val Thr Ile Leu Gly Asn Pro Ile Val Tyr Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Pro Pro Val Leu Leu Ile Gln Leu Ala Ser Asn 
            180                 185                 190         
Val Gln Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Asp Pro Leu Glu Glu Glu Asp Val Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

<210>  48
<211>  246
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(246)
<223>  scFv


<400>  48
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg His Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Glu Ser Gly Val Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Val Leu Asn Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Leu Tyr Ser Leu Asp Phe Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
        115                 120                 125             
Gly Glu Gly Ser Thr Lys Gly Glu Ile Val Leu Thr Gln Ser Pro Pro 
    130                 135                 140                 
Thr Leu Ala Met Ser Leu Gly Lys Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 
Ser Glu Ser Val Thr Ile Leu Gly Ser His Leu Ile Tyr Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn 
            180                 185                 190         
Val Gln Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Asp Pro Leu Glu Glu Glu Asp Val Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

<210>  49
<211>  246
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(246)
<223>  scFv


<400>  49
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Glu Ser Gly Ala Pro Asn Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Glu Ile Asn Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Leu Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
        115                 120                 125             
Gly Glu Gly Ser Thr Lys Gly Glu Ile Val Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 
Thr Leu Ser Val Ser Leu Gly Gln Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 
Ser Arg Ser Val Ser Val Ala Gly Asn His Ile Val Tyr Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Pro Pro Val Leu Leu Ile Gln Leu Ala Ser Asn 
            180                 185                 190         
Val Gln Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Asp Ser Leu Glu Pro Glu Asp Val Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

<210>  50
<211>  246
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(246)
<223>  scFv


<400>  50
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Gly Ser Gly Ala Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Ile Phe Ser Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
        115                 120                 125             
Gly Glu Gly Ser Thr Lys Gly Glu Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 
Thr Leu Ser Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
145                 150                 155                 160 
Ser Arg Ser Val Thr Ile Leu Gly Asn Pro Ile Val Tyr Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Pro Pro Val Leu Leu Ile Gln Leu Ala Ser Asn 
            180                 185                 190         
Val Gln Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Glu Asp Asp Val Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

<210>  51
<211>  246
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(246)
<223>  scFv


<400>  51
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Arg Ser Gly Thr Pro Asn Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Asn Leu Lys Ser Glu Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
        115                 120                 125             
Gly Glu Gly Ser Thr Lys Gly Asp Ile Val Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 
Ser Leu Ser Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
145                 150                 155                 160 
Ser Arg Ser Val Thr Ile Leu Gly Asn Pro Ile Val Tyr Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Pro Pro Val Leu Leu Ile Gln Leu Ala Ser Asn 
            180                 185                 190         
Val Gln Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

<210>  52
<211>  246
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(246)
<223>  scFv


<400>  52
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Gly Ser Gly Ala Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Val Leu Asn Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
        115                 120                 125             
Gly Glu Gly Ser Thr Lys Gly Glu Ile Val Met Thr Gln Ser Pro Pro 
    130                 135                 140                 
Thr Leu Ser Val Ser Leu Gly Gln Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 
Ser Arg Ser Val Thr Ile Leu Gly Asn Pro Ile Val Tyr Trp Tyr Gln 
                165                 170                 175     
Gln Lys Ala Pro Lys Pro Pro Val Leu Leu Ile Gln Leu Ala Ser Asn 
            180                 185                 190         
Val Gln Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Asp Pro Leu Glu Glu Glu Asp Val Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

<210>  53
<211>  246
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(246)
<223>  scFv


<400>  53
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg His Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Glu Ser Gly Val Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Val Leu Asn Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Leu Tyr Ser Leu Asp Phe Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
        115                 120                 125             
Gly Glu Gly Ser Thr Lys Gly Glu Ile Val Leu Thr Gln Ser Pro Pro 
    130                 135                 140                 
Thr Leu Ala Met Ser Leu Gly Lys Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 
Ser Glu Ser Val Thr Ile Leu Gly Ser His Leu Ile Tyr Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn 
            180                 185                 190         
Val Gln Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Asp Pro Leu Glu Glu Glu Asp Val Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Val Glu Ile Lys 
                245     

<210>  54
<211>  246
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(246)
<223>  scFv


<400>  54
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Glu Ser Gly Ala Pro Asn Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Thr Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Glu Ile Asn Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Leu Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
        115                 120                 125             
Gly Glu Gly Ser Thr Lys Gly Glu Ile Val Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 
Thr Leu Ser Val Ser Leu Gly Gln Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 
Ser Arg Ser Val Ser Val Ala Gly Asn His Ile Val Tyr Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Pro Pro Val Leu Leu Ile Gln Leu Ala Ser Asn 
            180                 185                 190         
Val Gln Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Val Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

<210>  55
<211>  246
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(246)
<223>  scFv


<400>  55
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Gly Ser Gly Ala Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Ile Phe Ser Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
        115                 120                 125             
Gly Glu Gly Ser Thr Lys Gly Glu Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 
Thr Leu Ser Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
145                 150                 155                 160 
Ser Arg Ser Val Thr Ile Leu Gly Asn Pro Ile Val Tyr Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Pro Pro Val Leu Leu Ile Gln Leu Ala Ser Asn 
            180                 185                 190         
Val Gln Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

<210>  56
<211>  246
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(246)
<223>  scFv


<400>  56
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Thr Arg Ser Gly Thr Pro Asn Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Asn Leu Lys Ser Glu Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      
Ser Asn Asp Tyr Asn Tyr Ser Leu Asp His Trp Gly Gln Gly Thr Ala 
            100                 105                 110         
Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
        115                 120                 125             
Gly Glu Gly Ser Thr Lys Gly Asp Ile Val Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 
Ser Leu Ser Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
145                 150                 155                 160 
Ser Arg Ser Val Thr Ile Leu Gly Asn Pro Ile Val Tyr Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Pro Pro Val Leu Leu Ile Gln Leu Ala Ser Asn 
            180                 185                 190         
Val Gln Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

