               SEQUENCE LISTING

<110> IDP DISCOVERY PHARMA S.L.

<120> VEGF_regulating peptides

<130> 906 772

<150> EP 20383169.8
<151> 2020-12-29

<160> 37

<170> BiSSAP 1.3.6

<210> 1
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> X represents (Leu)m, wherein m is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 2..2
<223> X represents (Asp)n, wherein n is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 17..17
<223> X represents (Arg)p, wherein p is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> X represents (Lys)q, wherein q is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18;

<400> 1
Xaa Xaa Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val 
1               5                   10                  15      
Xaa Xaa 
        

<210> 2
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> X represents (Leu)m, wherein m is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> a N-terminal end corresponds to -NHR5, wherein R5 is selected
      from the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 2..2
<223> X represents (Asp)n, wherein n is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 5..5
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 12 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 12..12
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 5 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 17..17
<223> X represents (Arg)p, wherein p is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> X represents (Lys)q, wherein q is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18;

<400> 2
Xaa Xaa Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val 
1               5                   10                  15      
Xaa Xaa 
        

<210> 3
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> X represents (Leu)m, wherein m is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 2..2
<223> X represents (Asp)n, wherein n is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 7..7
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 14 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 14..14
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 7 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 17..17
<223> X represents (Arg)p, wherein p is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> X represents (Lys)q, wherein q is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 3
Xaa Xaa Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val 
1               5                   10                  15      
Xaa Xaa 
        

<210> 4
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> X represents (Leu)m, wherein m is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 2..2
<223> X represents (Asp)n, wherein n is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 8..8
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 15 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 8 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 17..17
<223> X represents (Arg)p, wherein p is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> X represents (Lys)q, wherein q is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 4
Xaa Xaa Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val 
1               5                   10                  15      
Xaa Xaa 
        

<210> 5
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> X represents (Leu)m, wherein m is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 2..2
<223> X represents (Asp)n, wherein n is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 10..10
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 17 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 17..17
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 10 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> X represents (Lys)q, wherein q is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 5
Xaa Xaa Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val 
1               5                   10                  15      
Arg Xaa 
        

<210> 6
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 3..3
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 10 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 10..10
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 3 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 6
Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val Arg 
1               5                   10                  15  

<210> 7
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 5..5
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 12 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 12..12
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 5 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 7
Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val Arg 
1               5                   10                  15  

<210> 8
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 6..6
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 13 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 13..13
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 6 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 8
Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val Arg 
1               5                   10                  15  

<210> 9
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 8..8
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 15 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 8 by a linker "L

<400> 9
Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val Arg 
1               5                   10                  15  

<210> 10
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 5..5
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 12 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 12..12
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 5 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 10
Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val 
1               5                   10                  15      
Arg Lys 
        

<210> 11
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 7..7
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 12 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 14..14
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 7 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 11
Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val 
1               5                   10                  15      
Arg Lys 
        

<210> 12
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 8..8
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 15 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of the amino acid at
      position 8 by a linker "L

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 12
Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val 
1               5                   10                  15      
Arg Lys 
        

<210> 13
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<400> 13
Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val 
1               5                   10                  15      
Arg Lys 
        

<210> 14
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 3..3
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 10 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 10..10
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 3 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> C-terminal end corresponds to -C(O)NH2

<400> 14
Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val Arg 
1               5                   10                  15  

<210> 15
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 5..5
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 12 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 12..12
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 5 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> C-terminal end corresponds to -C(O)NH2

<400> 15
Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val Arg 
1               5                   10                  15  

<210> 16
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 6..6
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 13 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 13..13
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 6 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> C-terminal end corresponds to -C(O)NH2

<400> 16
Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val Arg 
1               5                   10                  15  

<210> 17
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 6..6
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 13 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 13..13
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 6 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<400> 17
Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val Arg 
1               5                   10                  15  

<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 8..8
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 15 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 8 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> C-terminal end corresponds to -C(O)NH2

<400> 18
Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val Arg 
1               5                   10                  15  

<210> 19
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 5..5
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 12 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 12..12
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 5 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> C-terminal end corresponds to -C(O)NH2

<400> 19
Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val 
1               5                   10                  15      
Arg Lys 
        

<210> 20
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 7..7
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 14 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 14..14
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 7 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> C-terminal end corresponds to -C(O)NH2

<400> 20
Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val 
1               5                   10                  15      
Arg Lys 
        

<210> 21
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 8..8
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 15 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 8 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> C-terminal end corresponds to -C(O)NH2

<400> 21
Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val 
1               5                   10                  15      
Arg Lys 
        

<210> 22
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> X represents (Arg)r, wherein r is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 2..2
<223> X represents (Ser)s, wherein s is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> X represents (Leu)t, wherein t is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 19..19
<223> X represents (Pro)v, wherein v is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 19..19
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 22
Xaa Xaa Arg Arg Ser Lys Glu Ser Glu Val Phe Tyr Glu Leu Ala His 
1               5                   10                  15      
Gln Xaa Xaa 
            

<210> 23
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> X represents (Arg)r, wherein r is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 2..2
<223> X represents (Ser)s, wherein s is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 8..8
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of amino acid at
      position 15 by the linker "L

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of amino acid at
      position 8 by the linker "L

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> X represents (Leu)t, wherein t is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 19..19
<223> X represents (Pro)v, wherein v is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 19..19
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 23
Xaa Xaa Arg Arg Ser Lys Glu Ser Glu Val Phe Tyr Glu Leu Ala His 
1               5                   10                  15      
Gln Xaa Xaa 
            

<210> 24
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> X represents (Arg)r, wherein r is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 2..2
<223> X represents (Ser)s, wherein s is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 10..10
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of amino acid at
      position 17 by the linker "L

<220> 
<221> MISC_FEATURE
<222> 17..17
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of amino acid at
      position 10 by the linker "L

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> X represents (Leu)t, wherein t is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 19..19
<223> X represents (Pro)v, wherein v is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 19..19
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 24
Xaa Xaa Arg Arg Ser Lys Glu Ser Glu Val Phe Tyr Glu Leu Ala His 
1               5                   10                  15      
Gln Xaa Xaa 
            

<210> 25
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> X represents (Arg)r, wherein r is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 2..2
<223> X represents (Ser)s, wherein s is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 5..5
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of amino acid at
      position 12 by the linker "L

<220> 
<221> MISC_FEATURE
<222> 12..12
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of amino acid at
      position 5 by the linker "L

<220> 
<221> MISC_FEATURE
<222> 18..18
<223> X represents (Leu)t, wherein t is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 19..19
<223> X represents (Pro)v, wherein v is 0 or 1

<220> 
<221> MISC_FEATURE
<222> 19..19
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 25
Xaa Xaa Arg Arg Ser Lys Glu Ser Glu Val Phe Tyr Glu Leu Ala His 
1               5                   10                  15      
Gln Xaa Xaa 
            

<210> 26
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 8..8
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of amino acid at
      position 15 by the linker "L

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of amino acid at
      position 8 by the linker "L

<220> 
<221> MISC_FEATURE
<222> 17..17
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 26
Arg Ser Arg Arg Ser Lys Glu Ser Glu Val Phe Tyr Glu Leu Ala His 
1               5                   10                  15      
Gln 
    

<210> 27
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 10..10
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of amino acid at
      position 17 by the linker "L

<220> 
<221> MISC_FEATURE
<222> 17..17
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of amino acid at
      position 10 by the linker "L

<220> 
<221> MISC_FEATURE
<222> 17..17
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 27
Arg Ser Arg Arg Ser Lys Glu Ser Glu Val Phe Tyr Glu Leu Ala His 
1               5                   10                  15      
Gln 
    

<210> 28
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 1..1
<223> N-terminal end corresponds to -NHR5, wherein R5 is selected from
      the group consisting of -H and (C1-C20)alkyl

<220> 
<221> MISC_FEATURE
<222> 3..3
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of amino acid at
      position 10 by the linker "L

<220> 
<221> MISC_FEATURE
<222> 10..10
<223> the amino acid is of formula (I), the alpha carbon of this amino
      acid being connected to the alpha carbon of amino acid at
      position 3 by the linker "L

<220> 
<221> MISC_FEATURE
<222> 19..19
<223> C-terminal end corresponds to -C(O)R4, wherein R4 is a radical
      selected from the group consisting of -OH and -NR17R18

<400> 28
Arg Ser Arg Arg Ser Lys Glu Ser Glu Val Phe Tyr Glu Leu Ala His 
1               5                   10                  15      
Gln Leu Pro 
            

<210> 29
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 8..8
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 15 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 15..15
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 8 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 17..17
<223> C-terminal end corresponds to -C(O)NH2

<400> 29
Arg Ser Arg Arg Ser Lys Glu Ser Glu Val Phe Tyr Glu Leu Ala His 
1               5                   10                  15      
Gln 
    

<210> 30
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 10..10
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 17 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 17..17
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 10 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 17..17
<223> C-terminal end corresponds to -C(O)NH2

<400> 30
Arg Ser Arg Arg Ser Lys Glu Ser Glu Val Phe Tyr Glu Leu Ala His 
1               5                   10                  15      
Gln 
    

<210> 31
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> MISC_FEATURE
<222> 3..3
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 10 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 10..10
<223> the amino acid is of formula (I), being R19 a -CH3 radical; the
      alpha carbon of this amino acid being connected to the alpha
      carbon of amino acid at position 3 by the linker
      -(CH2)6-CH=CH-(CH2)3-

<220> 
<221> MISC_FEATURE
<222> 19..19
<223> C-terminal end corresponds to -C(O)NH2

<400> 31
Arg Ser Arg Arg Ser Lys Glu Ser Glu Val Phe Tyr Glu Leu Ala His 
1               5                   10                  15      
Gln Leu Pro 
            

<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 32
agaaaatctg gcaccacacc                                                20


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 33
ggggtgttga aggtctcaaa                                                20


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 34
tactgccatc caatcgagac                                                20


<210> 35
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 35
gcatggtgat gttggact                                                  18


<210> 36
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Lineal sequence derived from SEQ ID NO:1 (m,n,q=0; p=1)

<400> 36
Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val Arg 
1               5                   10                  15  

<210> 37
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> Lineal sequence derived from SEQ ID NO:1 (m, n,p, q=0)

<400> 37
Lys Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val 
1               5                   10                  

