                         SEQUENCE LISTING

<110>  Vascular Venture Korltolt Felelssg Trsasg
 
<120>  Chlorotoxin derivatives and use thereof

<130>  20-32-HU

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  36
<212>  PRT
<213>  Leiurus quinquestriatus

<400>  1

Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Met Ala Arg Lys Cys 
1               5                   10                  15      


Asp Asp Cys Cys Gly Gly Lys Gly Arg Gly Lys Cys Tyr Gly Pro Gln 
            20                  25                  30          


Cys Leu Cys Arg 
        35      


<210>  2
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  monolysine (K27) mutant of CTX

<400>  2

Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Met Ala Arg Arg Cys 
1               5                   10                  15      


Asp Asp Cys Cys Gly Gly Arg Gly Arg Gly Lys Cys Tyr Gly Pro Gln 
            20                  25                  30          


Cys Leu Cys Arg 
        35      


<210>  3
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  3

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Asp Lys Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg 
        35      


<210>  4
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  4

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Asp Lys Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  5
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  5

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Asp Lys Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly 
        35          


<210>  6
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  6

Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg Cys 
1               5                   10                  15      


Asp Lys Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys Leu 
            20                  25                  30          


Cys Asn Arg Gly Tyr 
        35          


<210>  7
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  7

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Asp Lys Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg 
        35      


<210>  8
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  8

Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg Cys Asp 
1               5                   10                  15      


Lys Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys Leu Cys 
            20                  25                  30          


Asn Arg Gly Tyr 
        35      


<210>  9
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  9

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Asp Lys Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn 
        35  


<210>  10
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  10

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Arg Asp Cys Cys Gly Gly Tyr Gly Lys Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  11
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  11

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Ile Lys Cys Cys Gly Gly Tyr Gly Tyr Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  12
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  12

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys His Lys Cys Cys Gly Gly Tyr Gly Trp Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  13
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  13

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Asp Arg Cys Cys Gly Gly Tyr Gly Lys Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  14
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  14

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Leu Lys Cys Cys Gly Gly Tyr Gly Gln Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  15
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  15

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Asp Lys Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Arg 
        35  


<210>  16
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  16

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Lys Asp Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  17
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  17

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Lys Lys Cys Cys Gly Gly Tyr Gly Lys Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  18
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  18

Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg Cys 
1               5                   10                  15      


Lys Lys Cys Cys Gly Gly Tyr Gly Lys Cys Phe Gly Tyr Gln Cys Leu 
            20                  25                  30          


Cys Asn Arg Gly Tyr 
        35          


<210>  19
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  19

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Lys Trp Cys Cys Gly Gly Tyr Gly Ile Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  20
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  20

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Val Lys Cys Cys Gly Gly Tyr Gly Phe Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  21
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  21

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Lys His Cys Cys Gly Gly Tyr Gly Val Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  22
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  22

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Lys Phe Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  23
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  23

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Lys Trp Cys Cys Gly Gly Tyr Gly Trp Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  24
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  24

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Asp Lys Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys 
        


<210>  25
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  25

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Lys Ser Cys Cys Gly Gly Tyr Gly Phe Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  26
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  26

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Lys Arg Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  27
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  27

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Arg Phe Cys Cys Gly Gly Tyr Gly Lys Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  28
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  28

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Val Trp Cys Cys Gly Gly Tyr Gly Lys Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  29
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  29

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Asp Asp Cys Cys Gly Gly Tyr Gly Lys Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  30
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  30

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Arg Lys Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  31
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  31

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Trp Lys Cys Cys Gly Gly Tyr Gly Trp Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  32
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  32

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Arg Arg Cys Cys Gly Gly Tyr Gly Lys Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  33
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  33

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Arg Trp Cys Cys Gly Gly Tyr Gly Lys Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  34
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  34

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Leu Lys Cys Cys Gly Gly Tyr Gly Ser Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  35
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  35

Xaa Xaa Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Xaa Xaa Cys Cys Gly Gly Tyr Gly Xaa Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Xaa Xaa Xaa Xaa 
        35              


<210>  36
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  36

Ala Met Cys Met Pro Cys Ser Ser Ser Asp His Glu Ser Ala Arg Arg 
1               5                   10                  15      


Cys Asp Lys Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  37
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  37

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Asp Lys Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Arg Arg 
        35              


<210>  38
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  38

Ala Met Cys Met Pro Cys Ser Ser Ser Asp His Glu Ser Ala Arg Arg 
1               5                   10                  15      


Cys Asp Lys Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Arg Arg 
        35              


<210>  39
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  39

Ala Met Cys Met Pro Cys Ser Ser Ser Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Asp Lys Cys Cys Gly Gly Tyr Gly Arg Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  40
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  40

Ala Met Cys Met Pro Cys Ser Ser Ser Asp His Glu Ser Ala Arg Arg 
1               5                   10                  15      


Cys Arg Asp Cys Cys Gly Gly Tyr Gly Lys Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Gly Tyr 
        35              


<210>  41
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  41

Ala Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Thr Ala Arg Arg 
1               5                   10                  15      


Cys Arg Asp Cys Cys Gly Gly Tyr Gly Lys Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Arg Arg 
        35              


<210>  42
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative

<400>  42

Ala Met Cys Met Pro Cys Ser Ser Ser Asp His Glu Ser Ala Arg Arg 
1               5                   10                  15      


Cys Arg Asp Cys Cys Gly Gly Tyr Gly Lys Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Asn Arg Arg Arg 
        35              


<210>  43
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chlorotoxin derivative


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  43

Xaa Xaa Cys Met Pro Cys Xaa Xaa Xaa Asp His Xaa Xaa Ala Arg Arg 
1               5                   10                  15      


Cys Xaa Xaa Cys Cys Gly Gly Tyr Gly Xaa Cys Phe Gly Tyr Gln Cys 
            20                  25                  30          


Leu Cys Xaa Xaa Xaa Xaa 
        35              


<210>  44
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTXD8-CAR construct

<400>  44

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Ala Met Cys Met Pro Cys Ser Ser Ser Asp 
            20                  25                  30          


His Glu Ser Ala Arg Arg Cys Arg Asp Cys Cys Gly Gly Tyr Gly Lys 
        35                  40                  45              


Cys Phe Gly Tyr Gln Cys Leu Cys Asn Arg Arg Arg Thr Thr Thr Pro 
    50                  55                  60                  


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
65                  70                  75                  80  


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
                85                  90                  95      


Thr Arg Gly Leu Asp Phe Ala Cys Asp Met Phe Trp Val Leu Val Val 
            100                 105                 110         


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        115                 120                 125             


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp 
    130                 135                 140                 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
145                 150                 155                 160 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly Gly 
                165                 170                 175     


Gly Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            180                 185                 190         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        195                 200                 205             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    210                 215                 220                 


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
225                 230                 235                 240 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                245                 250                 255     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            260                 265                 270         


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        275                 280                 285             


Pro Arg Ala Ser Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly 
    290                 295                 300                 


Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro Arg Leu Leu Phe 
305                 310                 315                 320 


Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro Glu Glu Pro Leu 
                325                 330                 335     


Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys 
            340                 345                 350         


Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser 
        355                 360                 365             


Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly 
    370                 375                 380                 


Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser 
385                 390                 395                 400 


Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu 
                405                 410                 415     


Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu 
            420                 425                 430         


Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu 
        435                 440                 445             


Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met 
    450                 455                 460                 


Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu 
465                 470                 475                 480 


Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu 
                485                 490                 495     


Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys 
            500                 505                 510         


Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His 
        515                 520                 525             


Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp 
    530                 535                 540                 


Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu 
545                 550                 555                 560 


Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly 
                565                 570                 575     


Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu 
            580                 585                 590         


Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val Ser Ala Val Thr 
        595                 600                 605             


Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val Gly Ile Leu His 
    610                 615                 620                 


Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys Arg Met Thr Asp 
625                 630                 635                 640 


Pro Thr Arg Arg Phe 
                645 


