                         SEQUENCE LISTING

<110>  REGENXBIO Inc.
 
<120>  TAU-SPECIFIC ANTIBODY GENE THERAPY COMPOSITIONS, METHODS AND USES
        THEREOF

<130>  38013.0006P1

<150>  63/131,660
<151>  2020-12-29

<150>  63/139,496
<151>  2021-01-20

<160>  397   

<170>  PatentIn version 3.5

<210>  1
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody chain

<400>  1
gaggtgcagc tggtgcagtc tggagcagag gtgaagaagc ccggggagtc tctgaagatc       60

tcctgtaagg tttctggata cgactttagc aagtactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggctc atctatcctg gtgactctga taccagatat      180

agtccatctt tggaagggca agtcagcatc tcagccgaca agtccatcag cgccgcctac      240

ttgcaattca gcagcctgaa ggcctcggac agcgccatgt attattgtgt gaggaaggga      300

tatagtgcct accttggagg gtggttcgac ccctggggcc agggaaccct ggtcaccgtc      360

tcctcg                                                                 366


<210>  2
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody chain

<400>  2
gacatccagt tgacccagtc tccagactcc ctggctgcgt ctctgggcga gagggtcacc       60

atcaactgca ggtccagcca gaatattttt tacaactcca acaataagaa cttcttagct      120

tggtatcagc agaaagcagg acagtctcct aagttgctta tttactgggc ttctacgcgg      180

gaatccgggg tccctgaccg attcagtggc agcggctctg ggacagattt cactctcacc      240

atcagcggcc tgcaggctgg agatgtggca gtttatttct gtcagcaata ttttactgat      300

gctcccactt tcggcggagg gaccaaggtg gagatcaaa                             339


<210>  3
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody chain

<400>  3
gaggtgcagc tgttgcagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc       60

tcctgtgaag cctctggatt caccttcagt tcctattcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggaatg gctgacactt atctcatata atggagtcaa taagtattac      180

gcaaagtccg tgaagggccg attcgccatc tccagagacg attccaagag cacactgttt      240

ttgcaaatga acagcctgac aactgacgac acggctgtat attactgtgc gagatgtcca      300

atcccgcggg cggcgtcgta tagaaatgga gataattatt tcgaattcgg ccagggcacc      360

ctggtcaccg tctcctcg                                                    378


<210>  4
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody chain

<400>  4
caggctgtgg tgactcagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtgccc tgagttctgc ctcagtctct acttcttcgt accccagctg gtaccagcag      120

accccaggcc agcctccacg catgctcatc cacaacacag acactcgctc ttctggtgtc      180

cctgatcgct tctctggctc catccttggg aagaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaatctga ttactactgt gtggtatatt tggggaatgg cttttgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  5
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  5
gaggtgcagc tggtggagtc tgggggaggc ttggtgcagc cgggggggtc cctaagactc       60

tcctgtgcag cctccggatt cacctttagc atctatacca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attctcagtg atggtagcac atactatgca      180

gactccgtag agggccgatt caccatctcc agagacaatt ccaagaccac cctgtatcta      240

caaatgaaca gcctgacagc cgaggacacg gccgtatatt attgtacaaa acgtgttgag      300

gggagctttc gggggtgggg ccagggaacc ctggtcaccg tctcctcg                   348


<210>  6
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  6
gaaattgtga tgacacagtc tccaggcacc ctgtctttgt ctccagggga aagcgccacc       60

ctctcctgca gggccagtca gagtgttagc actacctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacagattca gtggcagtgg gtctgggaca gacttcactc tcacaatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggtg ggtcacgctt gatcaccttc      300

ggccaaggga cacgactgga gattaaa                                          327


<210>  7
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; transgene

<400>  7
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctggggagag cctgaagatc      120

agctgcaaag tgtctggcta tgacttcagc aagtactgga ttggctgggt cagacagatg      180

cctggcaaag gcctggaatg gatgggactg atctaccctg gggactctga caccagatac      240

agccctagcc tggaaggcca ggtgtccatc tctgctgaca agagcatctc tgcagcctac      300

ctgcagttca gcagcctgaa ggcctctgac tctgccatgt actactgtgt cagaaagggc      360

tactctgcct accttggagg atggtttgat ccttggggcc agggcacact ggtcacagtg      420

tcctctgcta agacaacagc cccttctgtg taccctctgg ctcctgtgtg tggggacaca      480

acaggatcct ctgtgacact gggctgcctg gtcaagggat acttccctga gccagtgaca      540

ctgacctgga actctggatc tctgtcctct ggggtgcaca cattccctgc tgtgctgcag      600

tctgacctgt acaccctgag cagcagtgtg acagtgacca gcagcacatg gcccagccag      660

agcatcacct gtaatgtggc tcaccctgcc agctccacca aggtggacaa gaagattgag      720

cctagaggcc ccaccatcaa gccctgtcct ccatgcaagt gtcctgctcc taacctgctt      780

ggaggcccct ctgtgttcat cttcccacct aagatcaagg atgtgctgat gatctctctg      840

agccccattg tgacctgtgt ggtggtggat gtgtctgagg atgaccctga tgtgcagatc      900

tcttggtttg tgaacaatgt ggaagtgcac acagcccaga cacagaccca cagagaggac      960

tacaacagca ccctgagagt ggtgtctgcc ctgcctatcc agcaccagga ctggatgagt     1020

ggcaaagagt tcaagtgcaa agtgaacaac aaggacctgc ctgctccaat tgagagaacc     1080

atcagcaagc ccaagggctc tgttagagcc cctcaagtgt atgtgctgcc tccacctgag     1140

gaagagatga ccaagaaaca agtgaccctg acatgcatgg tcacagactt catgcctgag     1200

gacatctatg tggaatggac caacaatggc aagacagagc tgaactacaa gaacactgag     1260

cctgtgctgg actctgatgg cagctacttc atgtacagca agctgagggt tgagaagaag     1320

aactgggttg agagaaacag ctacagctgc tctgtggtgc atgagggcct gcacaatcac     1380

cacaccacca agagcttcag cagaacccct ggcaagagaa agagaagagg ctctggagaa     1440

ggcagaggct ccctgctgac atgtggggat gttgaagaga atcctgggcc tatgtatagg     1500

atgcaactgc tcctcctgat tgctctgagc ctggctcttg tgaccaactc tgacatccag     1560

ctgacacaga gccctgacag cctggctgct tctctgggag agagagtgac catcaactgc     1620

agaagctccc agaacatctt ctacaacagc aacaacaaga acttcctggc ctggtatcag     1680

cagaaggctg gccagtctcc taagctgctg atctactggg ccagcaccag agaatctggg     1740

gtgccagata gattttctgg cagtggctct ggcacagact tcaccctgac aatcagtgga     1800

ctgcaggctg gggatgttgc tgtgtacttc tgccagcagt acttcacaga tgcccctacc     1860

tttggtggtg gcaccaaggt ggaaatcaag agggctgatg ctgcccctac agtgtctatc     1920

ttcccaccta gctctgagca gctgaccagt ggtggtgcct ctgttgtgtg cttcctgaac     1980

aacttctacc ccaaggacat caatgtgaag tggaagattg atggctctga gaggcagaat     2040

ggggtgctga acagctggac agaccaggac agcaaggact ccacctacag catgagcagc     2100

acactgaccc tgaccaagga tgagtatgag aggcacaaca gctacacctg tgaagccaca     2160

cacaagacca gcacaagccc cattgtgaag tccttcaaca gaaatgagtg ttaa           2214


<210>  8
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; transgene

<400>  8
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggtgcagc tgctgcagag tggtggtggt gttgtgcagc ctggtggctc tctgagactg      120

tcttgtgaag cctctggctt caccttcagc agctacagca tgcactgggt cagacaggcc      180

cctggcaaag gactggaatg gctgaccctg atcagctaca atggggtcaa caagtactat      240

gccaagtctg tgaagggcag atttgccatc agcagagatg acagcaagtc taccctgttc      300

ctgcagatga acagcctgac cacagatgac actgctgtgt actactgtgc cagatgtccc      360

attcctagag ctgccagcta cagaaatggg gacaactact ttgagtttgg ccagggcacc      420

ctggtcacag tgtcctctgc taagacaaca gccccttctg tgtaccctct ggctcctgtg      480

tgtggggaca caacaggatc ctctgtgaca ctgggctgcc tggtcaaggg ctactttcct      540

gagccagtga cactgacctg gaactctgga tctctgtcct ctggggtgca cacattccct      600

gctgtgctgc agtctgacct gtacaccctg agcagcagtg tgacagtgac cagcagcaca      660

tggcccagcc agagcatcac ctgtaatgtg gctcaccctg ccagctccac caaggtggac      720

aagaagattg agcctagagg ccccaccatc aagccctgtc ctccatgcaa gtgtcctgct      780

cctaacctgc ttggaggccc ctctgtgttc atcttcccac ctaagatcaa ggatgtgctg      840

atgatctctc tgagccccat tgtgacctgt gtggtggttg atgtgtctga ggatgaccca      900

gatgtgcaga tctcttggtt tgtgaacaat gtggaagtgc acacagccca gacacagacc      960

cacagagagg actacaacag caccctgaga gtggtgtctg ccctgcctat ccagcaccag     1020

gactggatgt ctggcaaaga gttcaagtgc aaagtgaaca acaaggacct gcctgctcca     1080

attgagagaa ccatcagcaa gcccaagggc tctgttagag cccctcaagt gtatgtgctg     1140

cctccacctg aggaagagat gaccaagaaa caagtgaccc tgacatgcat ggtcactgac     1200

ttcatgcctg aggacatcta tgtggaatgg accaacaatg gcaagacaga gctgaactac     1260

aagaacactg agcctgtgct ggactctgat ggcagctact tcatgtacag caagctgagg     1320

gttgagaaga agaactgggt tgagagaaac agctactcct gctctgtggt gcatgagggc     1380

ctgcacaacc atcacaccac aaagagcttc agcagaaccc caggcaagag aaagagaaga     1440

ggctctggag aaggcagagg ctccctgctg acatgtgggg atgttgaaga gaatcctggg     1500

cctatgtata ggatgcaact gctcctcctg attgctctga gcctggctct tgtgaccaac     1560

tctcaggctg tggtcaccca agagcctagc ctgtctgtgt ctcctggtgg cacagtgaca     1620

ctgacatgtg ccctgtcctc tgcctctgtg tctaccagca gctaccccag ctggtatcag     1680

cagacacctg gccagcctcc aagaatgctg atccacaaca cagacaccag atcctctggg     1740

gtgccagaca gattctctgg cagcatcctg ggcaagaagg ctgccctgac aatcactggt     1800

gcccaggctg atgatgagtc tgactactac tgtgtggtgt accttggcaa tggcttctgg     1860

gtgtttggtg gtggcaccaa gctgacagtg ctgggccagc ctaaaagcag cccctctgtg     1920

acactgttcc ctccaagctc tgaggaactg gaaacaaaca aggccacact tgtgtgcacc     1980

atcacagact tctaccctgg ggttgtgaca gtggactgga aagtggatgg cacccctgtg     2040

acacaaggca tggaaaccac acagcccagc aagcagagca acaacaagta catggccagc     2100

tcctatctga ccctgacagc cagagcctgg gagagacaca gctcttacag ctgccaagtg     2160

acccatgagg gccacacagt ggaaaagagc ctgagcagag ctgactgctc ttaa           2214


<210>  9
<211>  2184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; transgene

<400>  9
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggtgcagc tggtggaaag tggtggtgga ctggttcagc ctggtggcag cctgagactg      120

tcttgtgctg cctctggctt caccttcagc atctacacca tgagctgggt cagacaggct      180

cctggcaaag gcctggaatg ggtgtcagct atcctgtctg atggcagcac ctactatgct      240

gactctgtgg aaggcagatt caccatcagc agagacaaca gcaagaccac actgtacctg      300

cagatgaaca gcctgacagc tgaggacact gctgtgtact actgcaccaa gagagtggaa      360

ggctccttca gaggctgggg acagggaaca ctggtcactg tgtcctctgc caagacaact      420

gccccttctg tgtaccctct ggctcctgtg tgtggggaca caacaggatc ctctgtgaca      480

ctgggctgcc tggtcaaggg ctactttcct gagccagtga cactgacctg gaactctgga      540

tctctgtcct ctggggtgca cacattccct gctgtgctgc agtctgacct gtacaccctg      600

agcagctctg tgactgtgac cagcagcaca tggcccagcc agagcatcac ctgtaatgtg      660

gctcaccctg ccagctccac caaggtggac aagaagattg agcctagagg ccccaccatc      720

aagccctgtc ctccatgcaa gtgtcctgct cctaacctgc ttggaggccc ctctgtgttc      780

atcttcccac ctaagatcaa ggatgtgctg atgatctctc tgagccccat tgtgacctgt      840

gtggtggttg atgtgtctga ggatgaccct gatgtgcaga tctcttggtt tgtgaacaat      900

gtggaagtgc acacagccca gacacagacc cacagagagg actacaacag caccctgaga      960

gtggtgtctg ccctgcctat ccagcaccag gactggatgt ctggcaaaga gttcaagtgc     1020

aaagtgaaca acaaggacct gcctgctcca attgagagaa ccatctccaa gcctaagggc     1080

tctgtcaggg cccctcaagt gtatgtgctg ccacctcctg aggaagagat gaccaagaaa     1140

caagtgaccc tgacatgcat ggtcacagac ttcatgcctg aggacatcta tgtggaatgg     1200

accaacaatg gcaagacaga gctgaactac aagaacactg agcctgtgct ggactctgat     1260

ggctcctact tcatgtacag caagctgagg gttgagaaga agaactgggt tgagagaaac     1320

agctacagct gctctgtggt gcatgagggc ctgcacaatc accacaccac caagagcttc     1380

agcagaaccc ctggcaagag aaagagaaga ggctctggag aaggcagagg ctccctgctg     1440

acatgtgggg atgttgaaga gaatcctggg cctatgtata ggatgcaact gctcctcctg     1500

attgctctga gcctggctct tgtgaccaac tctgagattg tgatgacaca gagccctggc     1560

acactgtctc tgagccctgg ggaatctgcc acactgagct gtagagccag ccagtctgtg     1620

tctaccacct acctggcctg gtatcagcag aagcctggac aggctcccag actgctgatc     1680

tatggggcct cttctagagc cacaggcatc cctgacagat tttctggcag tggctctggc     1740

acagacttca ccctgaccat cagcagactg gaacctgagg actttgctgt gtactactgc     1800

cagcagtatg gtggcagcag gctgatcaca tttggccagg gcacaagact ggaaatcaag     1860

agggctgatg ctgcccctac agtgtctatc ttcccaccta gctctgagca gctgaccagt     1920

ggtggtgcct ctgttgtgtg cttcctgaac aacttctacc ccaaggacat caatgtgaag     1980

tggaagattg atggctctga gaggcagaat ggggtgctga acagctggac agaccaggac     2040

agcaaggact ccacctacag catgagcagc accctgacac tgaccaagga tgagtatgag     2100

aggcacaaca gctacacctg tgaagccaca cacaagacca gcacaagccc cattgtgaag     2160

tccttcaaca gaaatgagtg ttaa                                            2184


<210>  10
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; transgene

<400>  10
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctggggagag cctgaagatc      120

agctgcaaag tgtctggcta tgacttcagc aagtactgga ttggctgggt cagacagatg      180

cctggcaaag gcctggaatg gatgggactg atctaccctg gggactctga caccagatac      240

agccctagcc tggaaggcca ggtgtccatc tctgctgaca agagcatctc tgcagcctac      300

ctgcagttca gcagcctgaa ggcctctgac tctgccatgt actactgtgt cagaaagggc      360

tactctgcct accttggagg atggtttgat ccttggggcc agggcacact ggtcacagtg      420

tcctctgcta agacaacagc cccttctgtg taccctctgg ctcctgtgtg tggggacaca      480

acaggatcct ctgtgacact gggctgcctg gtcaagggat acttccctga gccagtgaca      540

ctgacctgga actctggatc tctgtcctct ggggtgcaca cattccctgc tgtgctgcag      600

tctgacctgt acaccctgag cagcagtgtg acagtgacca gcagcacatg gcccagccag      660

agcatcacct gtaatgtggc tcaccctgcc agctccacca aggtggacaa gaagattgag      720

cctagaggcc ccaccatcaa gccctgtcct ccatgcaagt gtcctgctcc taacgctgcc      780

ggaggcccct ctgtgttcat cttcccacct aagatcaagg atgtgctgat gatctctctg      840

agccccattg tgacctgtgt ggtggtggat gtgtctgagg atgaccctga tgtgcagatc      900

tcttggtttg tgaacaatgt ggaagtgcac acagcccaga cacagaccca cagagaggac      960

tacaacagca ccctgagagt ggtgtctgcc ctgcctatcc agcaccagga ctggatgagt     1020

ggcaaagagt tcaagtgcaa agtgaacaac aaggacctgg gcgctccaat tgagagaacc     1080

atcagcaagc ccaagggctc tgttagagcc cctcaagtgt atgtgctgcc tccacctgag     1140

gaagagatga ccaagaaaca agtgaccctg acatgcatgg tcacagactt catgcctgag     1200

gacatctatg tggaatggac caacaatggc aagacagagc tgaactacaa gaacactgag     1260

cctgtgctgg actctgatgg cagctacttc atgtacagca agctgagggt tgagaagaag     1320

aactgggttg agagaaacag ctacagctgc tctgtggtgc atgagggcct gcacaatcac     1380

cacaccacca agagcttcag cagaacccct ggcaagagaa agagaagagg ctctggagaa     1440

ggcagaggct ccctgctgac atgtggggat gttgaagaga atcctgggcc tatgtatagg     1500

atgcaactgc tcctcctgat tgctctgagc ctggctcttg tgaccaactc tgacatccag     1560

ctgacacaga gccctgacag cctggctgct tctctgggag agagagtgac catcaactgc     1620

agaagctccc agaacatctt ctacaacagc aacaacaaga acttcctggc ctggtatcag     1680

cagaaggctg gccagtctcc taagctgctg atctactggg ccagcaccag agaatctggg     1740

gtgccagata gattttctgg cagtggctct ggcacagact tcaccctgac aatcagtgga     1800

ctgcaggctg gggatgttgc tgtgtacttc tgccagcagt acttcacaga tgcccctacc     1860

tttggtggtg gcaccaaggt ggaaatcaag agggctgatg ctgcccctac agtgtctatc     1920

ttcccaccta gctctgagca gctgaccagt ggtggtgcct ctgttgtgtg cttcctgaac     1980

aacttctacc ccaaggacat caatgtgaag tggaagattg atggctctga gaggcagaat     2040

ggggtgctga acagctggac agaccaggac agcaaggact ccacctacag catgagcagc     2100

acactgaccc tgaccaagga tgagtatgag aggcacaaca gctacacctg tgaagccaca     2160

cacaagacca gcacaagccc cattgtgaag tccttcaaca gaaatgagtg ttaa           2214


<210>  11
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; transgene

<400>  11
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggtgcagc tgctgcagag tggtggtggt gttgtgcagc ctggtggctc tctgagactg      120

tcttgtgaag cctctggctt caccttcagc agctacagca tgcactgggt cagacaggcc      180

cctggcaaag gactggaatg gctgaccctg atcagctaca atggggtcaa caagtactat      240

gccaagtctg tgaagggcag atttgccatc agcagagatg acagcaagtc taccctgttc      300

ctgcagatga acagcctgac cacagatgac actgctgtgt actactgtgc cagatgtccc      360

attcctagag ctgccagcta cagaaatggg gacaactact ttgagtttgg ccagggcacc      420

ctggtcacag tgtcctctgc taagacaaca gccccttctg tgtaccctct ggctcctgtg      480

tgtggggaca caacaggatc ctctgtgaca ctgggctgcc tggtcaaggg ctactttcct      540

gagccagtga cactgacctg gaactctgga tctctgtcct ctggggtgca cacattccct      600

gctgtgctgc agtctgacct gtacaccctg agcagcagtg tgacagtgac cagcagcaca      660

tggcccagcc agagcatcac ctgtaatgtg gctcaccctg ccagctccac caaggtggac      720

aagaagattg agcctagagg ccccaccatc aagccctgtc ctccatgcaa gtgtcctgct      780

cctaacgctg ccggaggccc ctctgtgttc atcttcccac ctaagatcaa ggatgtgctg      840

atgatctctc tgagccccat tgtgacctgt gtggtggttg atgtgtctga ggatgaccca      900

gatgtgcaga tctcttggtt tgtgaacaat gtggaagtgc acacagccca gacacagacc      960

cacagagagg actacaacag caccctgaga gtggtgtctg ccctgcctat ccagcaccag     1020

gactggatgt ctggcaaaga gttcaagtgc aaagtgaaca acaaggacct gggagctcca     1080

attgagagaa ccatcagcaa gcccaagggc tctgttagag cccctcaagt gtatgtgctg     1140

cctccacctg aggaagagat gaccaagaaa caagtgaccc tgacatgcat ggtcactgac     1200

ttcatgcctg aggacatcta tgtggaatgg accaacaatg gcaagacaga gctgaactac     1260

aagaacactg agcctgtgct ggactctgat ggcagctact tcatgtacag caagctgagg     1320

gttgagaaga agaactgggt tgagagaaac agctactcct gctctgtggt gcatgagggc     1380

ctgcacaacc atcacaccac aaagagcttc agcagaaccc caggcaagag aaagagaaga     1440

ggctctggag aaggcagagg ctccctgctg acatgtgggg atgttgaaga gaatcctggg     1500

cctatgtata ggatgcaact gctcctcctg attgctctga gcctggctct tgtgaccaac     1560

tctcaggctg tggtcaccca agagcctagc ctgtctgtgt ctcctggtgg cacagtgaca     1620

ctgacatgtg ccctgtcctc tgcctctgtg tctaccagca gctaccccag ctggtatcag     1680

cagacacctg gccagcctcc aagaatgctg atccacaaca cagacaccag atcctctggg     1740

gtgccagaca gattctctgg cagcatcctg ggcaagaagg ctgccctgac aatcactggt     1800

gcccaggctg atgatgagtc tgactactac tgtgtggtgt accttggcaa tggcttctgg     1860

gtgtttggtg gtggcaccaa gctgacagtg ctgggccagc ctaaaagcag cccctctgtg     1920

acactgttcc ctccaagctc tgaggaactg gaaacaaaca aggccacact tgtgtgcacc     1980

atcacagact tctaccctgg ggttgtgaca gtggactgga aagtggatgg cacccctgtg     2040

acacaaggca tggaaaccac acagcccagc aagcagagca acaacaagta catggccagc     2100

tcctatctga ccctgacagc cagagcctgg gagagacaca gctcttacag ctgccaagtg     2160

acccatgagg gccacacagt ggaaaagagc ctgagcagag ctgactgctc ttaa           2214


<210>  12
<211>  2184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; transgene

<400>  12
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggtgcagc tggtggaaag tggtggtgga ctggttcagc ctggtggcag cctgagactg      120

tcttgtgctg cctctggctt caccttcagc atctacacca tgagctgggt cagacaggct      180

cctggcaaag gcctggaatg ggtgtcagct atcctgtctg atggcagcac ctactatgct      240

gactctgtgg aaggcagatt caccatcagc agagacaaca gcaagaccac actgtacctg      300

cagatgaaca gcctgacagc tgaggacact gctgtgtact actgcaccaa gagagtggaa      360

ggctccttca gaggctgggg acagggaaca ctggtcactg tgtcctctgc caagacaact      420

gccccttctg tgtaccctct ggctcctgtg tgtggggaca caacaggatc ctctgtgaca      480

ctgggctgcc tggtcaaggg ctactttcct gagccagtga cactgacctg gaactctgga      540

tctctgtcct ctggggtgca cacattccct gctgtgctgc agtctgacct gtacaccctg      600

agcagctctg tgactgtgac cagcagcaca tggcccagcc agagcatcac ctgtaatgtg      660

gctcaccctg ccagctccac caaggtggac aagaagattg agcctagagg ccccaccatc      720

aagccctgtc ctccatgcaa gtgtcctgct cctaacgccg ctggaggccc ctctgtgttc      780

atcttcccac ctaagatcaa ggatgtgctg atgatctctc tgagccccat tgtgacctgt      840

gtggtggttg atgtgtctga ggatgaccct gatgtgcaga tctcttggtt tgtgaacaat      900

gtggaagtgc acacagccca gacacagacc cacagagagg actacaacag caccctgaga      960

gtggtgtctg ccctgcctat ccagcaccag gactggatgt ctggcaaaga gttcaagtgc     1020

aaagtgaaca acaaggacct gggagctcca attgagagaa ccatctccaa gcctaagggc     1080

tctgtcaggg cccctcaagt gtatgtgctg ccacctcctg aggaagagat gaccaagaaa     1140

caagtgaccc tgacatgcat ggtcacagac ttcatgcctg aggacatcta tgtggaatgg     1200

accaacaatg gcaagacaga gctgaactac aagaacactg agcctgtgct ggactctgat     1260

ggctcctact tcatgtacag caagctgagg gttgagaaga agaactgggt tgagagaaac     1320

agctacagct gctctgtggt gcatgagggc ctgcacaatc accacaccac caagagcttc     1380

agcagaaccc ctggcaagag aaagagaaga ggctctggag aaggcagagg ctccctgctg     1440

acatgtgggg atgttgaaga gaatcctggg cctatgtata ggatgcaact gctcctcctg     1500

attgctctga gcctggctct tgtgaccaac tctgagattg tgatgacaca gagccctggc     1560

acactgtctc tgagccctgg ggaatctgcc acactgagct gtagagccag ccagtctgtg     1620

tctaccacct acctggcctg gtatcagcag aagcctggac aggctcccag actgctgatc     1680

tatggggcct cttctagagc cacaggcatc cctgacagat tttctggcag tggctctggc     1740

acagacttca ccctgaccat cagcagactg gaacctgagg actttgctgt gtactactgc     1800

cagcagtatg gtggcagcag gctgatcaca tttggccagg gcacaagact ggaaatcaag     1860

agggctgatg ctgcccctac agtgtctatc ttcccaccta gctctgagca gctgaccagt     1920

ggtggtgcct ctgttgtgtg cttcctgaac aacttctacc ccaaggacat caatgtgaag     1980

tggaagattg atggctctga gaggcagaat ggggtgctga acagctggac agaccaggac     2040

agcaaggact ccacctacag catgagcagc accctgacac tgaccaagga tgagtatgag     2100

aggcacaaca gctacacctg tgaagccaca cacaagacca gcacaagccc cattgtgaag     2160

tccttcaaca gaaatgagtg ttaa                                            2184


<210>  13
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; transgene

<400>  13
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaagtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctggggagag cctgaagatc      120

agctgcaaag tgtctggcta tgacttcagc aagtactgga ttggctgggt cagacagatg      180

cctggcaaag gcctggaatg gatgggcctg atctaccctg gggactctga caccagatac      240

agccctagcc tggaaggcca ggtgtccatc tctgctgaca agagcatctc tgcagcctac      300

ctgcagttca gcagcctgaa ggcctctgac tctgccatgt actactgtgt cagaaagggc      360

tactctgcct accttggagg atggtttgat ccttggggcc agggcacact ggttacagtg      420

tcctctgcca gcacaaaggg cccctctgtt tttccactgg ctcccagcag caagtccacc      480

agtggtggta cagctgccct gggctgtctg gtcaaggatt acttccctga gcctgtgact      540

gtgtcctgga actctggtgc tctgacctct ggggtgcaca cctttccagc tgtgctgcag      600

tcctctggcc tgtactctct gtcctctgtg gtcacagtgc ctagctctag cctgggcacc      660

cagacctaca tctgcaatgt gaaccacaag cctagcaaca ccaaggtgga caagagagtg      720

gaacccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agaactgctt      780

ggaggccctt ctgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      840

acccctgaag tgacctgtgt ggtggtggat gtgtcccatg aggacccaga agtgaagttc      900

aattggtatg tggatggggt tgaagtgcac aatgccaaga ccaagcctag agaggaacag      960

tacaacagca cctacagagt ggtgtctgtg ctgacagtgc tgcaccagga ctggctgaat     1020

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat tgagaaaacc     1080

atcagcaagg ccaagggcca gccaagagaa ccccaggttt acaccctgcc acctagcaga     1140

gaagagatga ccaagaatca ggtgtccctg acctgcctgg ttaagggctt ctacccctct     1200

gacattgctg tggaatggga gagcaatggc cagcctgaga acaactacaa gacaacccct     1260

cctgtgctgg actctgatgg ctcattcttc ctgtacagca agctgactgt ggacaagtcc     1320

agatggcagc agggaaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac     1380

tacacccaga aaagtctgtc tctgtcccct ggcaagagaa agagaagagg ctctggagaa     1440

ggcagaggct ccctgctgac atgtggggat gttgaagaga atcctgggcc tatgtatagg     1500

atgcaactgc tcctcctgat tgctctgagc ctggctcttg tgaccaactc tgatatccag     1560

ctgacacaga gccctgacag cctggctgct tctctgggag agagagtgac catcaactgc     1620

agaagctccc agaacatctt ctacaactcc aacaacaaga acttcctggc ctggtatcag     1680

caaaaggctg gacagagccc caagctgctg atctactggg cctctaccag agagtctggg     1740

gtcccagaca gattctctgg ctctggatct ggcacagact tcaccctgac catcagtgga     1800

ctgcaggctg gggatgttgc tgtgtacttc tgccagcagt acttcacaga tgcccctacc     1860

tttggtggtg gcacaaaggt ggaaatcaag agaacagtgg ctgccccatc tgtgttcatc     1920

ttcccaccat ctgatgaaca gctgaagtct ggcactgcct ctgttgtgtg cctgctgaac     1980

aacttctacc ctagagaagc caaggtgcag tggaaagtgg ataatgccct ccagtctggc     2040

aatagccaag agtcagtgac agagcaggac tccaaggatt ccacctacag cctgagcagc     2100

accctgacac tgagcaaggc tgactatgag aagcacaaag tgtatgcctg tgaagtgaca     2160

caccagggac tgagcagccc agtgaccaag agcttcaaca ggggagagtg ctga           2214


<210>  14
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; transgene

<400>  14
atgtacagga tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaagtgcagc ttctgcagtc tggtggtggt gttgtgcagc ctggtggctc tctgagactg      120

tcttgtgaag cctctggctt caccttcagc agctacagca tgcactgggt tagacaggcc      180

cctggcaaag gcctggaatg gctgaccctg atcagctaca atggggtcaa caagtactat      240

gccaagtctg tgaagggcag atttgccatc agcagagatg acagcaagag caccctgttt      300

ctgcagatga acagcctgac cacagatgac acagcagtgt actactgtgc cagatgtccc      360

attcctagag ctgccagcta cagaaatggg gacaactact ttgagtttgg ccagggcaca      420

ctggtcacag tgtcctctgc ctctacaaag ggcccctctg tgtttcctct ggctcctagc      480

agcaagtcca ccagtggtgg tacagctgcc ctgggctgtc tggtcaagga ttacttccct      540

gagcctgtga ctgtgtcctg gaattctggg gctctgacct ctggggtgca cacctttcca      600

gctgtgctgc agtcctctgg cctgtactct ctgtcctctg tggttacagt gccaagcagc      660

tctctgggca cccagaccta catctgcaat gtgaaccaca agcctagcaa caccaaggtg      720

gacaagagag tggaacccaa gagctgtgac aagacccaca cctgtcctcc atgtcctgct      780

ccagaactgc ttggaggccc atcagtgttt ctgttccctc caaagcctaa ggacaccctg      840

atgatcagca gaacccctga agtgacctgt gtggtggtgg atgtgtccca tgaggaccca      900

gaagtgaagt tcaattggta tgtggatggg gttgaagtgc acaatgccaa gaccaagcct      960

agagaggaac agtacaacag cacctacaga gtggtgtctg tgctgacagt gctgcaccag     1020

gactggctga atggcaaaga gtacaagtgc aaggtgtcca acaaggccct gcctgctcct     1080

attgagaaaa ccatcagcaa ggccaagggc cagccaagag aaccccaggt ttacaccctg     1140

ccacctagca gagaagagat gaccaagaac caggtgtccc tgacctgcct ggttaagggc     1200

ttctacccct ctgacattgc tgtggaatgg gagagcaatg gccagcctga gaacaactac     1260

aagacaaccc ctcctgtgct ggactctgat ggctcattct tcctgtacag caagctgact     1320

gtggacaagt ccagatggca gcagggaaat gtgttcagct gctctgtgat gcatgaggcc     1380

ctgcacaacc actacaccca gaaaagtctg agtctgagcc ctggcaagag aaagagaaga     1440

ggctctggag aaggcagagg cagcctgctg acatgtgggg atgttgaaga gaatcctggg     1500

cctatgtata gaatgcaact gctcctcctg attgctctga gcctggctct ggttaccaac     1560

agccaggctg tggtcacaca agagcccagc ctgtctgtgt ctcctggtgg aacagtgacc     1620

ctgacttgtg ccctctcttc tgcctctgtg tccacaagca gctaccccag ctggtatcag     1680

cagacacctg gccagccacc tagaatgctg atccacaaca ctgacaccag aagctctggg     1740

gtcccagaca gattctctgg cagcatcctg ggaaagaagg ctgccctgac aatcactggt     1800

gcccaggctg atgatgagtc tgactactat tgtgtggtgt accttggcaa tggcttttgg     1860

gtgttcggtg gtggcaccaa actgactgtg ctgggacagc ctaaagctgc cccttctgtg     1920

acactgttcc cacctagctc tgaggaactg caggccaaca aagccacact tgtgtgcctg     1980

atctctgact tctaccctgg ggctgtgaca gtggcttgga aggctgatag cagccctgtg     2040

aaggctgggg ttgagacaac cacacctagc aagcagagca acaacaaata tgctgcctcc     2100

agctatctgt ctctgacccc tgagcagtgg aagtcccaca gatcctacag ctgtcaagtg     2160

acccatgagg gctccacagt ggaaaagaca gtggccccaa cagagtgcag ctga           2214


<210>  15
<211>  2184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; transgene

<400>  15
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaagtgcagc tggtggaaag tggtggtgga ctggttcagc ctggtggcag cctgagactg      120

tcttgtgctg cctctggctt caccttcagc atctacacca tgagctgggt cagacaggcc      180

cctggcaaag gactggaatg ggtgtcagcc atcctgtctg atggcagcac ctactatgct      240

gactctgtgg aaggcagatt caccatcagc agagacaaca gcaagaccac actgtacctg      300

cagatgaaca gcctgacagc tgaggacaca gcagtgtact actgcaccaa gagagtggaa      360

ggctccttca gaggctgggg ccagggaaca ctggttacag tgtcctctgc cagcacaaag      420

ggcccctctg tttttccact ggctcccagc agcaagagca ccagtggtgg aacagctgcc      480

ctgggctgtc tggtcaagga ttacttccct gagcctgtga ctgtgtcctg gaactctggt      540

gcactgacct ctggggtgca cacctttcca gctgtgctgc agtcctctgg cctgtactct      600

ctgtcctctg tggtcacagt gcctagctct agcctgggca cccagaccta catctgcaat      660

gtgaaccaca agcctagcaa caccaaggtg gacaaaagag tggaacccaa gagctgtgac      720

aagacccaca cctgtcctcc atgtcctgct ccagaactgc ttggaggccc ttctgtgttc      780

ctgtttcctc caaagcctaa ggacaccctg atgatcagca gaacccctga agtgacctgt      840

gtggtggttg atgtgtccca tgaggaccca gaagtgaagt tcaattggta tgtggatggg      900

gttgaagtgc acaatgccaa gaccaagcct agagaggaac agtacaactc cacctacaga      960

gtggtgtctg tgctgacagt gctgcaccag gactggctga atggcaaaga gtacaagtgc     1020

aaggtgtcca acaaggccct gcctgctcct attgagaaaa ccatctccaa ggccaagggc     1080

cagccaagag aaccccaggt ttacaccctg ccacctagca gagaagagat gaccaagaac     1140

caggtgtccc tgacctgcct ggttaagggc ttctacccct ctgacattgc tgtggaatgg     1200

gagagcaatg gccagcctga aaacaactac aagacaaccc ctcctgtgct ggactcagat     1260

ggctcattct tcctgtacag caagctgact gtggacaagt ccaggtggca gcagggaaat     1320

gtgttcagct gctctgtgat gcatgaggcc ctgcacaacc actacaccca gaaaagtctg     1380

agtctgagcc ctggcaagag aaagagaaga ggctctggag aaggcagagg ctccctgctg     1440

acatgtgggg atgttgaaga gaatcctggg cctatgtata ggatgcaact gctcctcctg     1500

attgctctga gcctggctct tgtgaccaac tctgagattg tgatgacaca gagcccaggc     1560

acactgtcac tgtctccagg ggaatctgcc actctgagct gtagagccag ccagtctgtg     1620

tctaccacct acctggcctg gtatcagcaa aagcctggac aggctcccag actgctgatc     1680

tatggggcct cttctagagc cacaggcatc cctgacagat tttctggcag tggctctggc     1740

acagacttca ccctgaccat ctctagactg gaacctgagg actttgctgt ctactactgc     1800

cagcagtatg gtggctccag actgatcacc tttggccagg gcaccagact ggaaatcaag     1860

agaacagtgg ctgccccatc tgtgttcatc ttcccaccat ctgatgagca gctcaagtct     1920

ggcactgcct ctgttgtgtg cctgctgaac aacttctacc ctagagaagc caaggtgcag     1980

tggaaggttg acaatgccct gcagtctggc aatagccaag aatctgtgac agagcaggac     2040

tccaaggata gcacctacag cctgtctagc accctgacac tgagcaaggc tgactatgag     2100

aagcacaaag tgtatgcctg tgaagtgaca caccagggcc tgagcagccc agtgaccaag     2160

agcttcaata gaggggagtg ctga                                            2184


<210>  16
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker construct

<400>  16
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaag                     1725


<210>  17
<211>  380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; enhancer construct

<400>  17
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg                                                  380


<210>  18
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; chimeric intron

<400>  18
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  19
<211>  594
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  19
cgcgtggtac ctctggtcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc       60

aacgaccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      120

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      180

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      240

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctactcga      300

ggccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      360

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg ggggggcgcg      420

cgccaggcgg ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg      480

cagccaatca gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc      540

ggccctataa aaagcgaagc gcgcggcggg cgggagcggg atcagccacc gcgg            594


<210>  20
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter construct

<400>  20
tatataagga cgcgccgggt gtggcacagc tagttccgtc gcagccggga tttgggtcgc       60

agttcttgtt tgtggatcgc tgtgatcgtc acttggtgag tagcgggctg ctgggctggc      120

cggggctttc gtggccgccg ggccgctcgg tgggacggag gcgtgtggag agaccgccaa      180

gggctgtagt ctgggtccgc gagcaaggtt gccctgaact gggggttggg gggagcgcag      240

caaaatggcg gctgttcccg agtcttgaat ggaagacgct tgtgaggcgg gctgtgaggt      300

cgttgaaaca aggtgggggg catggtgggc ggcaagaacc caaggtcttg aggccttcgc      360

taatgcggga aagctcttat tcgggtgaga tgggctgggg caccatctgg ggaccctgac      420

gtgaagtttg tcactgactg gagaactcgg tttgtcgtct gttgcggggg cggcagttat      480

ggcggtgccg ttgggcagtg cacccgtacc tttgggagcg cgcgccctcg tcgtgtcgtg      540

acgtcacccg ttctgttggc ttataatgca gggtggggcc acctgccggt aggtgtgcgg      600

taggcttttc tccgtcgcag gacgcagggt tcgggcctag ggtaggctct cctgaatcga      660

caggcgccgg acctctggtg aggggaggga taagtgaggc gtcagtttct ctggtcggtt      720

ttatgtacct atcttcttaa gtagctgaag ctccggtttt gaactatgcg ctcggggttg      780

gcgagtgtgt tttgtgaagt tttttaggca ccttttgaaa tgtaatcatt tgggtcaata      840

tgtaattttc agtgttagac tagtaaattg tccgctaaat tctggccgtt tttggctttt      900

ttgttagac                                                              909


<210>  21
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; enhancer sequence

<400>  21
ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg       60

ccacgtcaga cgaagggcgc agcgagcgtc ctgatccttc cgcccggacg ctcaggacag      120

cggcccgctg ctcataagac tcggccttag aaccccagta tcagcagaag gacattttag      180

gacgggactt gggtgactct agggcactgg ttttctttcc agagagcgga acaggcgagg      240

aaaagtagtc ccttctcggc gattctgcgg agggatctcc gtggggcggt gaacgccgat      300

gat                                                                    303


<210>  22
<211>  448
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  22
agtgcaagtg ggttttagga ccaggatgag gcggggtggg ggtgcctacc tgacgaccga       60

ccccgaccca ctggacaagc acccaacccc cattccccaa attgcgcatc ccctatcaga      120

gagggggagg ggaaacagga tgcggcgagg cgcgtgcgca ctgccagctt cagcaccgcg      180

gacagtgcct tcgcccccgc ctggcggcgc gcgccaccgc cgcctcagca ctgaaggcgc      240

gctgacgtca ctcgccggtc ccccgcaaac tccccttccc ggccaccttg gtcgcgtccg      300

cgccgccgcc ggcccagccg gaccgcacca cgcgaggcgc gagatagggg ggcacgggcg      360

cgaccatctg cgctgcggcg ccggcgactc agcgctgcct cagtctgcgg tgggcagcgg      420

aggagtcgtg tcgtgcctga gagcgcag                                         448


<210>  23
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  23
ctgcagaggg ccctgcgtat gagtgcaagt gggttttagg accaggatga ggcggggtgg       60

gggtgcctac ctgacgaccg accccgaccc actggacaag cacccaaccc ccattcccca      120

aattgcgcat cccctatcag agagggggag gggaaacagg atgcggcgag gcgcgtgcgc      180

actgccagct tcagcaccgc ggacagtgcc ttcgcccccg cctggcggcg cgcgccaccg      240

ccgcctcagc actgaaggcg cgctgacgtc actcgccggt cccccgcaaa ctccccttcc      300

cggccacctt ggtcgcgtcc gcgccgccgc cggcccagcc ggaccgcacc acgcgaggcg      360

cgagataggg gggcacgggc gcgaccatct gcgctgcggc gccggcgact cagcgctgcc      420

tcagtctgc                                                              429


<210>  24
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  24
ctgcagaggg ccctgcgtat gagtgcaagt gggttttagg accaggatga ggcggggtgg       60

gggtgcctac ctgacgaccg accccgaccc actggacaag cacccaaccc ccattcccca      120

aattgcgcat cccctatcag agagggggag gggaaacagg atgcggcgag gcgcgtgcgc      180

actgccagct tcagcaccgc ggacagtgcc ttcgcccccg cctggcggcg cgcgccaccg      240

ccgcctcagc actgaaggcg cgctgacgtc actcgccggt cccccgcaaa ctccccttcc      300

cggccacctt ggtcgcgtcc gcgccgccgc cggcccagcc ggaccgcacc acgcgaggcg      360

cgagataggg gggcacgggc gcgaccatct gcgctgcggc gccggcgact cagcgctgcc      420

tcagtctgcg gtgggcagcg gaggagtcgt gtcgtgcctg agagcgcagg gcgcgcc         477


<210>  25
<211>  469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  25
ctgcagaggg ccctgcgtat gagtgcaagt gggttttagg accaggatga ggcggggtgg       60

gggtgcctac ctgacgaccg accccgaccc actggacaag cacccaaccc ccattcccca      120

aattgcgcat cccctatcag agagggggag gggaaacagg atgcggcgag gcgcgtgcgc      180

actgccagct tcagcaccgc ggacagtgcc ttcgcccccg cctggcggcg cgcgccaccg      240

ccgcctcagc actgaaggcg cgctgacgtc actcgccggt cccccgcaaa ctccccttcc      300

cggccacctt ggtcgcgtcc gcgccgccgc cggcccagcc ggaccgcacc acgcgaggcg      360

cgagataggg gggcacgggc gcgaccatct gcgctgcggc gccggcgact cagcgctgcc      420

tcagtctgcc aattgcagcg gaggagtcgt gtcgtgcctg agagcgcag                  469


<210>  26
<211>  571
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  26
cctgcagggc ccactagtat ctgcagaggg ccctgcgtat gagtgcaagt gggttttagg       60

accaggatga ggcggggtgg gggtgcctac ctgacgaccg accccgaccc actggacaag      120

cacccaaccc ccattcccca aattgcgcat cccctatcag agagggggag gggaaacagg      180

atgcggcgag gcgcgtgcgc actgccagct tcagcaccgc ggacagtgcc ttcgcccccg      240

cctggcggcg cgcgccaccg ccgcctcagc actgaaggcg cgctgacgtc actcgccggt      300

cccccgcaaa ctccccttcc cggccacctt ggtcgcgtcc gcgccgccgc cggcccagcc      360

ggaccgcacc acgcgaggcg cgagataggg gggcacgggc gcgaccatct gcgctgcggc      420

gccggcgact cagcgctgcc tcagtctgcg gtgggcagcg gaggagtcgt gtcgtgcctg      480

agagcgcagc tgtgctcctg ggcaccgcgc agtccgcccc cgcggctcct ggccagacca      540

cccctaggac cccctgcccc aagtcgcagc c                                     571


<210>  27
<211>  229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  27
agctgaatgg ggtccgcctc ttttccctgc ctaaacagac aggaactcct gccaattgag       60

ggcgtcaccg ctaaggctcc gccccagcct gggctccaca accaatgaag ggtaatctcg      120

acaaagagca aggggtgggg cgcgggcgcg caggtgcagc agcacacagg ctggtcggga      180

gggcggggcg cgacgtctgc cgtgcggggt cccggcatcg gttgcgcgc                  229


<210>  28
<211>  1675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  28
gtctgcaagc agacctggca gcattgggct ggccgccccc cagggcctcc tcttcatgcc       60

cagtgaatga ctcaccttgg cacagacaca atgttcgggg tgggcacagt gcctgcttcc      120

cgccgcaccc cagcccccct caaatgcctt ccgagaagcc cattgagtag ggggcttgca      180

ttgcacccca gcctgacagc ctggcatctt gggataaaag cagcacagcc ccctaggggc      240

tgcccttgct gtgtggcgcc accggcggtg gagaacaagg ctctattcag cctgtgccca      300

ggaaagggga tcaggggatg cccaggcatg gacagtgggt ggcagggggg gagaggaggg      360

ctgtctgctt cccagaagtc caaggacaca aatgggtgag gggactgggc agggttctga      420

ccctgtggga ccagagtgga gggcgtagat ggacctgaag tctccaggga caacagggcc      480

caggtctcag gctcctagtt gggcccagtg gctccagcgt ttccaaaccc atccatcccc      540

agaggttctt cccatctctc caggctgatg tgtgggaact cgaggaaata aatctccagt      600

gggagacgga ggggtggcca gggaaacggg gcgctgcagg aataaagacg agccagcaca      660

gccagctcat gcgtaacggc tttgtggagc tgtcaaggcc tggtctctgg gagagaggca      720

cagggaggcc agacaaggaa ggggtgacct ggagggacag atccaggggc taaagtcctg      780

ataaggcaag agagtgccgg ccccctcttg ccctatcagg acctccactg ccacatagag      840

gccatgattg acccttagac aaagggctgg tgtccaatcc cagcccccag ccccagaact      900

ccagggaatg aatgggcaga gagcaggaat gtgggacatc tgtgttcaag ggaaggactc      960

caggagtctg ctgggaatga ggcctagtag gaaatgaggt ggcccttgag ggtacagaac     1020

aggttcattc ttcgccaaat tcccagcacc ttgcaggcac ttacagctga gtgagataat     1080

gcctgggtta tgaaatcaaa aagttggaaa gcaggtcaga ggtcatctgg tacagccctt     1140

ccttcccttt tttttttttt tttttttttg tgagacaagg tctctctctg ttgcccaggc     1200

tggagtggcg caaacacagc tcactgcagc ctcaacctac tgggctcaag caatcctcca     1260

gcctcagcct cccaaagtgc tgggattaca agcatgagcc accccactca gccctttcct     1320

tcctttttaa ttgatgcata ataattgtaa gtattcatca tggtccaacc aaccctttct     1380

tgacccacct tcctagagag agggtcctct tgattcagcg gtcagggccc cagacccatg     1440

gtctggctcc aggtaccacc tgcctcatgc aggagttggc gtgcccagga agctctgcct     1500

ctgggcacag tgacctcagt ggggtgaggg gagctctccc catagctggg ctgcggccca     1560

accccacccc ctcaggctat gccagggggt gttgccaggg gcacccgggc atcgccagtc     1620

tagcccactc cttcataaag ccctcgcatc ccaggagcga gcagagccag agcat          1675


<210>  29
<211>  2043
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  29
agctctgagc tcctcctctg ctcgcccaat ccttccaacc ccctatggtg gtatggctga       60

cacagaaaat gtctgctcct gtatgggaca tttgcccctc ttctccaaat ataagacagg      120

atgaggccta gcttttgctg ctccaaagtt ttaaaagaac acattgcacg gcatttaggg      180

actctaaagg gtggaggagg aatgagggaa ttgcatcatg ccaaggctgg tcctcatcca      240

tcactgcttc cagggcccag agtggcttcc aggaagtatt cttacaaagg aagcccgatc      300

tgtagctaac actcagagcc cattttcctg cgttaacccc tcccgacctc atatacagga      360

gtaacatgat cagtgacctg ggggagctgg ccaaactgcg ggacctgccc aagctgaggg      420

ccttggtgct gctggacaac ccctgtgccg atgagactga ctaccgccag gaggccctgg      480

tgcagatggc acacctagag cgcctagaca aagagtacta tgaggacgag gaccgggcag      540

aagctgagga gatccgacag aggctgaagg aggaacagga gcaagaactc gacccggacc      600

aagacatgga accgtacctc ccgccaactt agtggctcct ctagcctgca gggacagtaa      660

aggtgatggc aggaaggcag cccccggagg tcaaaggctg ggcacgcggg aggagaggcc      720

agagtcagag gctgcgggta tctcagatat gaaggaaaga tgagagaggc tcaggaagag      780

gtaagaaaag acacaagaga ccagagaagg gagaagaatt agagagggag gcagaggacc      840

gctgtctcta cagacatagc tggtagagac tgggaggaag ggatgaaccc tgagcgcatg      900

aagggaagga ggtggctggt ggtatatgga ggatgtagct gggccaggga aaagatcctg      960

cactaaaaat ctgaagctaa aaataacagg acacggggtg gagaggcgaa aggagggcag     1020

agtgaggcag agagactgag aggcctgggg atgtgggcat tccggtaggg cacacagttc     1080

acttgtcttc tctttttcca ggaggccaaa gatgctgacg tcaagaactc ataatacccc     1140

agtggggacc accgcattca tagccctgtt acaagaagtg ggagatgttc ctttttgtcc     1200

cagactggaa atccgttaca tcccgaggct caggttctgt ggtggtcatc tctgtgtggc     1260

ttgttctgtg ggcctaccta aagtcctaag cacagctctc aagcagatcc gaggcgacta     1320

agatgctagt aggggttgtc tggagagaag agccgaggag gtgggctgtg atggatcagt     1380

tcagctttca aataaaaagg cgtttttata ttctgtgtcg agttcgtgaa cccctgtggt     1440

gggcttctcc atctgtctgg gttagtacct gccactatac tggaataagg ggacgcctgc     1500

ttccctcgag ttggctggac aaggttatga gcatccgtgt acttatgggg ttgccagctt     1560

ggtcctggat cgcccgggcc cttcccccac ccgttcggtt ccccaccacc acccgcgctc     1620

gtacgtgcgt ctccgcctgc agctcttgac tcatcggggc ccccgggtca catgcgctcg     1680

ctcggctcta taggcgccgc cccctgccca ccccccgccc gcgctgggag ccgcagccgc     1740

cgccactcct gctctctctg cgccgaagct tcgaggggct cgcatctctc cttcacgcgc     1800

ccgccgccct acctgaggcc gccatccacg ccggttgagt cgcgttctgc cgcctcccgc     1860

ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc     1920

gggcctttgt ccggcgctcc cttggagcct acctagactc agccggctct ccacgctttg     1980

cctgaccctg cttgctcaac tctacgtctt tgtttcgttt tctgttctgc gccgttacag     2040

atc                                                                   2043


<210>  30
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  30
gaggaggagg agagagaccg ggagggcgcc cgggaggcag ggcgcgcgca cactccgagg       60


<210>  31
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  31
gatgctgacg aaggctcgcg aggctgtgag cagccacagt gccctgctca gaagccccgg       60


<210>  32
<211>  364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  32
acttgtggac taagtttgtt cgcatcccct tctccaaccc cctcagtaca tcaccctggg       60

ggaacagggt ccacttgctc ctgggcccac acagtcctgc agtattgtgt atataaggcc      120

agggcaaaga ggagcaggtt ttaaagtgaa aggcaggcag gtgttgggga ggcagttacc      180

ggggcaacgg gaacagggcg tttcggaggt ggttgccatg gggacctgga tgctgacgaa      240

ggctcgcgag gctgtgagca gccacagtgc cctgctcaga agccccaagc tcgtcagtca      300

agccggttct ccgtttgcac tcaggagcac gggcaggcga gtggccccta gttctggggg      360

cagc                                                                   364


<210>  33
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  33
gtctcccgcg cccgcgcccg tgtcgccgcc gtgcccgcga gcgggagccg gagtcgccgc       60


<210>  34
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  34
cgtgtgcaga tgcagggcgc cggtgccctg cgggtgcggg tgcaggagca gcgtgtgcag       60


<210>  35
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  35
ccccacgcca ccctttctgg tcatctcccc tcccgccccg cccctgcgca cactccctcg       60


<210>  36
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  36
tctccccggt aaagtctcgc ggtgctgccg ggctcagccc cgtctcctcc tcttgctccc       60


<210>  37
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  37
cgcctcctcc gcccgccgcc cgggagccgc agccgccgcc gccactgcca ctcccgctct       60


<210>  38
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  38
tgggtgcccc cacccttccc ccatcctcct cccttcccca ctccaccctc gtcggtcccc       60


<210>  39
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  39
aaaaaaaaaa aaaaagccca ccctccagcc tcgctgcaaa gagaaaaccg gagcagccgc       60


<210>  40
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  40
tctcgcactc tcccttctcc tttataaagg ccggaacagc tgaaagggtg gcaacttctc       60


<210>  41
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  41
gccgcgtcca cctgtcggcc gggcccagcc gagcgcgcag cgggcacgcc gcgcgcgcgg       60


<210>  42
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  42
gcgccccgcc cccggcgctg agtcctgtga cagcccccgg gccgcctgca cttgcagcct       60


<210>  43
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  43
aaagaagagt cccctattcc tgaaacttac tctgtccgtg gtgctgaaac attgtaccga       60


<210>  44
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  44
cgtcctcaaa gagcagcaag ccttctccat cttaatttga ctctaccgca gagcagactt       60


<210>  45
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  45
atgcagctat tctgttgtat tctcattctc actctccctc ccttctctca ctctcactct       60


<210>  46
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  46
catgttagcg tccccagctg cagcccaggg agggagagag gctgcgctca gtctgagagt       60


<210>  47
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  47
tgacgtcaga gagagagttt aaaacagagg gagacggttg agagcacaca agccgcttta       60


<210>  48
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  48
gagtgaaaat aaaagattgt ataaatcgtg gggcatgtgg aattgtgtgt gcctgtgcgt       60


<210>  49
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  49
gccgcggcga ggaagctcca taaaagccct gtcgcgaccc gctctctgca ccccatccgc       60


<210>  50
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  50
cagtcctaag tataagccct ataaaatgat gggctttgaa atgctggtca gggtagagtg       60


<210>  51
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  51
ttttccatta atgttttcag actgctgttg accacaggta actgaaatca tggaaagaga       60


<210>  52
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter sequence

<400>  52
tggtcatatg agcagaaatg atgagaaaag cactttttaa tcttttcgca cttgctctgc       60


<210>  53
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  53
aatagccaga gcagaagcct atataggtgg ccatcccacc tccaggctca cttcccgaca       60


<210>  54
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  54
cagcgctcag attttgcagc ataaatttgc atccaggaca gaccagagca gaggctgagg       60


<210>  55
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  55
gcacgcacgc gcgcgcaggg ccaagcccga ggcagctcgc ccgcagctcg cactcgcagg       60


<210>  56
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  56
cccgcctctg gctcgcccga ggacgcgctg gcacgcctcc caccccctca ctctgactcc       60


<210>  57
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  57
cactgggctc cctttccctc aaatgctctg gggctctccg cgctttcctg agtccgggct       60


<210>  58
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  58
cacagaaaac tcctctgggc cacgcttccc gcctcgccga ggtctcccca gtctgcccct       60


<210>  59
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  59
ctctgccccc gcctaccccg gagccgtgca gccgcctctc cgaatctctc tcttctcctg       60


<210>  60
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  60
ctggatttat aatcgcccta taaagctcca gaggcggtca ggcacctgca gaggagcccc       60


<210>  61
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  61
gggacgcgcg ggcggggtgg gctgtgcccc gcgggaaccc cgccggcctg tgcgcttgct       60

g                                                                       61


<210>  62
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  62
ctccctcccg cgctccccgc gctcgggcgc cgcagagctg tccagcttca gtgccgaacc       60


<210>  63
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  63
gtactggtgt acaaggacaa ggtgactttt tttcttttcc cagattgaaa gggccaaaga       60


<210>  64
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  64
cctccgccgc tcagccccgg actccttacg tcagggtagc ggggtccccc ctccgcgcgg       60


<210>  65
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  65
ccaggagagc tcggcaagta tataaggaca gaggagcgcg ggaccaagcg gcggcgaagg       60


<210>  66
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  66
ttccttcagc tgtgtcttaa agtaaatctt gttgtggagc ggagccctca gctgagggag       60


<210>  67
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  67
gtaagtatct tcttcttccc ctcgtgagtc cctccccttt tccagaatca cttgcactgt       60


<210>  68
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  68
ggggcggagc ggagacagta ccttcggaga taatcctttc tcctgccgca gtggagagga       60


<210>  69
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  69
ccctgcctag tctccatata aaagcggcgc cgcctccccg ccctctctca ctccccgctc       60


<210>  70
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  70
gggcggccca gccccaggtt acgtcgtccc cagaaagaat ctggccaaca gtctggccgt       60


<210>  71
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  71
ggcaggttct cttacatcga ccgcttaaga gtcgcgctgt aagaagcaac acctcctcct       60

cgcctccgcc atccacccgg cagccgcgaa gcagcaacc                              99


<210>  72
<211>  865
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  72
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccacta cgggtttagg ctgcccatgt aaggaggcaa      180

ggcctgggga cacccgagat gcctggttat aattaaccca gacatgtggc tgcccccccc      240

ccccccaaca cctgctgcct ctaaaaataa ccctgtccct ggtggatccc actacgggtt      300

taggctgccc atgtaaggag gcaaggcctg gggacacccg agatgcctgg ttataattaa      360

cccagacatg tggctgcccc cccccccccc aacacctgct gcctctaaaa ataaccctgt      420

ccctggtgga tcccctgcat gcgaagatct tcgaacaagg ctgtggggga ctgagggcag      480

gctgtaacag gcttgggggc cagggcttat acgtgcctgg gactcccaaa gtattactgt      540

tccatgttcc cggcgaaggg ccagctgtcc cccgccagct agactcagca cttagtttag      600

gaaccagtga gcaagtcagc ccttggggca gcccatacaa ggccatgggg ctgggcaagc      660

tgcacgcctg ggtccggggt gggcacggtg cccgggcaac gagctgaaag ctcatctgct      720

ctcaggggcc cctccctggg gacagcccct cctggctagt cacaccctgt aggctcctct      780

atataaccca ggggcacagg ggctgccctc attctaccac cacctccaca gcacagacag      840

acactcagga gccagccagc gtcga                                            865


<210>  73
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  73
atggaggcgg tactatgtag atgagaattc aggagcaaac tgggaaaagc aactgcttcc       60

aaatatttgt gatttttaca gtgtagtttt ggaaaaactc ttagcctacc aattcttcta      120

agtgttttaa aatgtgggag ccagtacaca tgaagttata gagtgtttta atgaggctta      180

aatatttacc gtaactatga aatgctacgc atatcatgct gttcaggctc cgtggccacg      240

caactcatac t                                                           251


<210>  74
<211>  212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  74
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa       60

cgggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac ag                                    212


<210>  75
<211>  460
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  75
gggctggaag ctacctttga catcatttcc tctgcgaatg catgtataat ttctacagaa       60

cctattagaa aggatcaccc agcctctgct tttgtacaac tttcccttaa aaaactgcca      120

attccactgc tgtttggccc aatagtgaga actttttcct gctgcctctt ggtgcttttg      180

cctatggccc ctattctgcc tgctgaagac actcttgcca gcatggactt aaacccctcc      240

agctctgaca atcctctttc tcttttgttt tacatgaagg gtctggcagc caaagcaatc      300

actcaaagtt caaaccttat cattttttgc tttgttcctc ttggccttgg ttttgtacat      360

cagctttgaa aataccatcc cagggttaat gctggggtta atttataact aagagtgctc      420

tagttttgca atacaggaca tgctataaaa atggaaagat                            460


<210>  76
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  76
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agt                                                                    723


<210>  77
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; furin T2A

<400>  77
agaaagagaa gaggctctgg agaaggcaga ggctccctgc tgacatgtgg ggatgttgaa       60

gagaatcctg ggcct                                                        75


<210>  78
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; furin

<400>  78
agaaagagaa ga                                                           12


<210>  79
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; furin-linker

<400>  79
agaaagagaa gaggctctgg a                                                 21


<210>  80
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  80
ggctctgga                                                                9


<210>  81
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  81
ggctctggag gctctgga                                                     18


<210>  82
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  82
ggcggaggag gctct                                                        15


<210>  83
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; T2A

<400>  83
gaaggcagag gctccctgct gacatgtggg gatgttgaag agaatcctgg gcct             54


<210>  84
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; rabbit globin poly A

<400>  84
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcg                                                                127


<210>  85
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; b-globin polyA signal

<400>  85
ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc tctca            55


<210>  86
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; IL-2 leader peptide

<400>  86
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60


<210>  87
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; signaling sequence

<400>  87

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  88
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  88

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala 
            20                  25      


<210>  89
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  89

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala 
            20                  25                  


<210>  90
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  90

Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val 
1               5                   10                  15      


Ala Leu Ala 
            


<210>  91
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  91

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala 
        


<210>  92
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  92

Met Arg Leu Leu Ala Phe Leu Ser Leu Leu Ala Leu Val Leu Gln Glu 
1               5                   10                  15      


Thr Gly Thr 
            


<210>  93
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  93

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  94
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  94

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  95
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  95

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ile Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  96
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  96

Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala 
1               5                   10                  15  


<210>  97
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  97

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  98
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  98

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  99
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  99

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  100
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  100

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met 
        35                  40                  45              


Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn 
                85                  90                  95      


Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  101
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  102
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  102

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg 
                85                  90                  95      


Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 


<210>  103
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  103

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  104
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  104
gccagcacaa agggcccctc tgtttttcca ctggctccca gcagcaagag caccagtggt       60

ggaacagctg ccctgggctg tctggtcaag gattacttcc ctgagcctgt gactgtgtcc      120

tggaactctg gtgcactgac ctctggggtg cacacctttc cagctgtgct gcagtcctct      180

ggcctgtact ctctgtcctc tgtggtcaca gtgcctagct ctagcctggg cacccagacc      240

tacatctgca atgtgaacca caagcctagc aacaccaagg tggacaaaag agtggaaccc      300

aagagctgtg acaagaccca cacctgtcct ccatgtcctg ctccagaact gcttggaggc      360

ccttctgtgt tcctgtttcc tccaaagcct aaggacaccc tgatgatcag cagaacccct      420

gaagtgacct gtgtggtggt tgatgtgtcc catgaggacc cagaagtgaa gttcaattgg      480

tatgtggatg gggttgaagt gcacaatgcc aagaccaagc ctagagagga acagtacaac      540

tccacctaca gagtggtgtc tgtgctgaca gtgctgcacc aggactggct gaatggcaaa      600

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgctc ctattgagaa aaccatctcc      660

aaggccaagg gccagccaag agaaccccag gtttacaccc tgccacctag cagagaagag      720

atgaccaaga accaggtgtc cctgacctgc ctggttaagg gcttctaccc ctctgacatt      780

gctgtggaat gggagagcaa tggccagcct gaaaacaact acaagacaac ccctcctgtg      840

ctggactcag atggctcatt cttcctgtac agcaagctga ctgtggacaa gtccaggtgg      900

cagcagggaa atgtgttcag ctgctctgtg atgcatgagg ccctgcacaa ccactacacc      960

cagaaaagtc tgagtctgag ccctggcaag                                       990


<210>  105
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  105

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  106
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  106
gcgagcacca aaggcccgag cgtgtttccg ctggcgccgt gcagccgcag caccagcgaa       60

agcaccgcgg cgctgggctg cctggtgaaa gattattttc cggaaccggt gaccgtgagc      120

tggaacagcg gcgcgctgac cagcggcgtg catacctttc cggcggtgct gcagagcagc      180

ggcctgtata gcctgagcag cgtggtgacc gtgccgagca gcaactttgg cacccagacc      240

tatacctgca acgtggatca taaaccgagc aacaccaaag tggataaaac cgtggaacgc      300

aaatgctgcg tggaatgccc gccgtgcccg gcgccgccgg tggcgggccc gagcgtgttt      360

ctgtttccgc cgaaaccgaa agataccctg atgattagcc gcaccccgga agtgacctgc      420

gtggtggtgg atgtgagcca tgaagatccg gaagtgcagt ttaactggta tgtggatggc      480

gtggaagtgc ataacgcgaa aaccaaaccg cgcgaagaac agtttaacag cacctttcgc      540

gtggtgagcg tgctgaccgt ggtgcatcag gattggctga acggcaaaga atataaatgc      600

aaagtgagca acaaaggcct gccggcgccg attgaaaaaa ccattagcaa aaccaaaggc      660

cagccgcgcg aaccgcaggt gtataccctg ccgccgagcc gcgaagaaat gaccaaaaac      720

caggtgagcc tgacctgcct ggtgaaaggc ttttatccga gcgatattag cgtggaatgg      780

gaaagcaacg gccagccgga aaacaactat aaaaccaccc cgccgatgct ggatagcgat      840

ggcagctttt ttctgtatag caaactgacc gtggataaaa gccgctggca gcagggcaac      900

gtgtttagct gcagcgtgat gcatgaagcg ctgcataacc attataccca gaaaagcctg      960

agcctgagcc cgggcaaata a                                                981


<210>  107
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  107

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  108
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  108
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca atgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccgtgccc atcatgccca gcacctgaat tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcgtgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa gccttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  109
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  109

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  110
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  110

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  111
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  111
gcgagcacca aaggcccgag cgtgtttccg ctggcgccga gcagcaaaag caccagcggc       60

ggcaccgcgg cgctgggctg cctggtgaaa gattattttc cggaaccggt gaccgtgagc      120

tggaacagcg gcgcgctgac cagcggcgtg catacctttc cggcggtgct gcagagcagc      180

ggcctgtata gcctgagcag cgtggtgacc gtgccgagca gcagcctggg cacccagacc      240

tatatttgca acgtgaacca taaaccgagc aacaccaaag tggataaaaa agtggaaccg      300

aaaagctgcg ataaaaccca tacctgcccg ccgtgcccgg cgccggaagc ggcgggcggc      360

ccgagcgtgt ttctgtttcc gccgaaaccg aaagataccc tgatgattag ccgcaccccg      420

gaagtgacct gcgtggtggt ggatgtgagc catgaagatc cggaagtgaa atttaactgg      480

tatgtggatg gcgtggaagt gcataacgcg aaaaccaaac cgcgcgaaga acagtataac      540

agcacctatc gcgtggtgag cgtgctgacc gtgctgcatc aggattggct gaacggcaaa      600

gaatataaat gcaaagtgag caacaaagcg ctgggcgcgc cgattgaaaa aaccattagc      660

aaagcgaaag gccagccgcg cgaaccgcag gtgtataccc tgccgccgag ccgcgatgaa      720

ctgaccaaaa accaggtgag cctgacctgc ctggtgaaag gcttttatcc gagcgatatt      780

gcggtggaat gggaaagcaa cggccagccg gaaaacaact ataaaaccac cccgccggtg      840

ctggatagcg atggcagctt ttttctgtat agcaaactga ccgtggataa aagccgctgg      900

cagcagggca acgtgtttag ctgcagcgtg atgcatgaag cgctgcataa ccattatacc      960

cagaaaagcc tgagcctgag cccgggcaaa                                       990


<210>  112
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  112

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            100                 105                 110         


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
145                 150                 155                 160 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                165                 170                 175     


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            180                 185                 190         


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        195                 200                 205             


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    210                 215                 220                 


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
225                 230                 235                 240 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                245                 250                 255     


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            260                 265                 270         


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        275                 280                 285             


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    290                 295                 300                 


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
305                 310                 315                 320 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                325                 330 


<210>  113
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  113
gctaagacaa cagccccttc tgtgtaccct ctggctcctg tgtgtgggga cacaacagga       60

tcctctgtga cactgggctg cctggtcaag ggctactttc ctgagccagt gacactgacc      120

tggaactctg gatctctgtc ctctggggtg cacacattcc ctgctgtgct gcagtctgac      180

ctgtacaccc tgagcagcag tgtgacagtg accagcagca catggcccag ccagagcatc      240

acctgtaatg tggctcaccc tgccagctcc accaaggtgg acaagaagat tgagcctaga      300

ggccccacca tcaagccctg tcctccatgc aagtgtcctg ctcctaacct gcttggaggc      360

ccctctgtgt tcatcttccc acctaagatc aaggatgtgc tgatgatctc tctgagcccc      420

attgtgacct gtgtggtggt tgatgtgtct gaggatgacc cagatgtgca gatctcttgg      480

tttgtgaaca atgtggaagt gcacacagcc cagacacaga cccacagaga ggactacaac      540

agcaccctga gagtggtgtc tgccctgcct atccagcacc aggactggat gtctggcaaa      600

gagttcaagt gcaaagtgaa caacaaggac ctgcctgctc caattgagag aaccatcagc      660

aagcccaagg gctctgttag agcccctcaa gtgtatgtgc tgcctccacc tgaggaagag      720

atgaccaaga aacaagtgac cctgacatgc atggtcactg acttcatgcc tgaggacatc      780

tatgtggaat ggaccaacaa tggcaagaca gagctgaact acaagaacac tgagcctgtg      840

ctggactctg atggcagcta cttcatgtac agcaagctga gggttgagaa gaagaactgg      900

gttgagagaa acagctactc ctgctctgtg gtgcatgagg gcctgcacaa ccatcacacc      960

acaaagagct tcagcagaac cccaggcaag                                       990


<210>  114
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  114

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            100                 105                 110         


Pro Ala Pro Asn Ala Ala Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
145                 150                 155                 160 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                165                 170                 175     


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            180                 185                 190         


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        195                 200                 205             


Lys Asp Leu Gly Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    210                 215                 220                 


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
225                 230                 235                 240 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                245                 250                 255     


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            260                 265                 270         


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        275                 280                 285             


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    290                 295                 300                 


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
305                 310                 315                 320 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                325                 330 


<210>  115
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  115
gccaagacaa ctgccccttc tgtgtaccct ctggctcctg tgtgtgggga cacaacagga       60

tcctctgtga cactgggctg cctggtcaag ggctactttc ctgagccagt gacactgacc      120

tggaactctg gatctctgtc ctctggggtg cacacattcc ctgctgtgct gcagtctgac      180

ctgtacaccc tgagcagctc tgtgactgtg accagcagca catggcccag ccagagcatc      240

acctgtaatg tggctcaccc tgccagctcc accaaggtgg acaagaagat tgagcctaga      300

ggccccacca tcaagccctg tcctccatgc aagtgtcctg ctcctaacgc cgctggaggc      360

ccctctgtgt tcatcttccc acctaagatc aaggatgtgc tgatgatctc tctgagcccc      420

attgtgacct gtgtggtggt tgatgtgtct gaggatgacc ctgatgtgca gatctcttgg      480

tttgtgaaca atgtggaagt gcacacagcc cagacacaga cccacagaga ggactacaac      540

agcaccctga gagtggtgtc tgccctgcct atccagcacc aggactggat gtctggcaaa      600

gagttcaagt gcaaagtgaa caacaaggac ctgggagctc caattgagag aaccatctcc      660

aagcctaagg gctctgtcag ggcccctcaa gtgtatgtgc tgccacctcc tgaggaagag      720

atgaccaaga aacaagtgac cctgacatgc atggtcacag acttcatgcc tgaggacatc      780

tatgtggaat ggaccaacaa tggcaagaca gagctgaact acaagaacac tgagcctgtg      840

ctggactctg atggctccta cttcatgtac agcaagctga gggttgagaa gaagaactgg      900

gttgagagaa acagctacag ctgctctgtg gtgcatgagg gcctgcacaa tcaccacacc      960

accaagagct tcagcagaac ccctggcaag                                       990


<210>  116
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  116

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  117
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  117
agaacagtgg ctgccccatc tgtgttcatc ttcccaccat ctgatgagca gctcaagtct       60

ggcactgcct ctgttgtgtg cctgctgaac aacttctacc ctagagaagc caaggtgcag      120

tggaaggttg acaatgccct gcagtctggc aatagccaag aatctgtgac agagcaggac      180

tccaaggata gcacctacag cctgtctagc accctgacac tgagcaaggc tgactatgag      240

aagcacaaag tgtatgcctg tgaagtgaca caccagggcc tgagcagccc agtgaccaag      300

agcttcaata gaggggagtg c                                                321


<210>  118
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  118

Gly Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp 
            20                  25                  30          


Phe Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro 
        35                  40                  45              


Val Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu 
65                  70                  75                  80  


Arg His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val 
                85                  90                  95      


Glu Lys Ser Leu Ser Arg Ala Asp Cys Ser 
            100                 105     


<210>  119
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  119
ggccagccta aaagcagccc ctctgtgaca ctgttccctc caagctctga ggaactggaa       60

acaaacaagg ccacacttgt gtgcaccatc acagacttct accctggggt tgtgacagtg      120

gactggaaag tggatggcac ccctgtgaca caaggcatgg aaaccacaca gcccagcaag      180

cagagcaaca acaagtacat ggccagctcc tatctgaccc tgacagccag agcctgggag      240

agacacagct cttacagctg ccaagtgacc catgagggcc acacagtgga aaagagcctg      300

agcagagctg actgctct                                                    318


<210>  120
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Tau epitope

<400>  120

Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala 
1               5                   10      


<210>  121
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; tau epitope

<400>  121

Pro Met Pro Asp Leu Lys Asn 
1               5           


<210>  122
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; tau epitope


<220>
<221>  misc
<222>  (8)..(8)
<223>  Serine is phosphorylated

<220>
<221>  misc
<222>  (11)..(11)
<223>  Threonine is phosphorylated

<400>  122

Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser 
1               5                   10                  15      


Arg Thr 
        


<210>  123
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; tau epitope


<220>
<221>  misc
<222>  (9)..(9)
<223>  Threonine is phosphorylated

<220>
<221>  misc
<222>  (11)..(11)
<223>  Serine is phosphorylated

<400>  123

Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro 
1               5                   10                  15      


Thr Arg 
        


<210>  124
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  124

Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu Tyr 
1               5                   10                  15      


Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
            20                  25                  30      


<210>  125
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  125

Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
1               5                   10                  15      


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            20                  25                  30      


<210>  126
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  126

Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
1               5                   10                  15      


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            20                  25                  30      


<210>  127
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  127

Gly Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr 
1               5                   10                  15      


Thr Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
            20                  25                  30      


<210>  128
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  128

Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr 
1               5                   10                  15      


Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
            20                  25                  30      


<210>  129
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  129

Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu Tyr 
1               5                   10                  15      


Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
            20                  25                  30      


<210>  130
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  130

Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val Tyr 
1               5                   10                  15      


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            20                  25                  30      


<210>  131
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  131

Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val Tyr 
1               5                   10                  15      


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            20                  25                  30      


<210>  132
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  132

Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr 
1               5                   10                  15      


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            20                  25                  30      


<210>  133
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  133

Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp Gly Thr Tyr 
1               5                   10                  15      


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            20                  25                  30      


<210>  134
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  134

Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr 
1               5                   10                  15      


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            20                  25                  30      


<210>  135
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  135

Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr 
1               5                   10                  15      


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            20                  25                  30      


<210>  136
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  136

Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr 
1               5                   10                  15      


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            20                  25                  30      


<210>  137
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  137

Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr 
1               5                   10                  15      


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            20                  25                  30      


<210>  138
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; furin 2A linker

<400>  138

Arg Lys Arg Arg Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe 
1               5                   10                  15      


Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25                  30      


<210>  139
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  139

Arg Lys Arg Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
1               5                   10                  15      


Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25  


<210>  140
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  140

Gly Ser Gly 
1           


<210>  141
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  141

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  142
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  142

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  143
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  143

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  144
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  144

Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys 
1               5                   10                  15      


Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25          


<210>  145
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; linker

<400>  145

Arg Lys Arg Arg 
1               


<210>  146
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  146

Arg Arg Arg Arg 
1               


<210>  147
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  147

Arg Arg Lys Arg 
1               


<210>  148
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  148

Arg Lys Lys Arg 
1               


<210>  149
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  149

Gly Gly Gly Gly Ser 
1               5   


<210>  150
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  150

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  151
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  151

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  152
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  152

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  153
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  153

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  154
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  154

Lys Tyr Trp Ile Gly 
1               5   


<210>  155
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  155

Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Glu Phe Glu Arg Glu 
1               5                   10                  15  


<210>  156
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  156

Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro 
1               5                   10              


<210>  157
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  157

Arg Ser Ser Gln Asn Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu 
1               5                   10                  15      


Ala 
    


<210>  158
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  158

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  159
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  159

Gln Gln Tyr Phe Thr Asp Ala Pro Thr 
1               5                   


<210>  160
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  160

Ser Tyr Ser Met His 
1               5   


<210>  161
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  161

Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  162
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  162

Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn Tyr Phe 
1               5                   10                  15      


Glu 
    


<210>  163
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  163

Ala Leu Ser Ser Ala Ser Val Ser Thr Ser Ser Tyr Pro Ser 
1               5                   10                  


<210>  164
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  164

Asn Thr Asp Thr Arg Ser Ser 
1               5           


<210>  165
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  165

Val Val Tyr Leu Gly Asn Gly Phe Trp Val 
1               5                   10  


<210>  166
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  166

Ile Tyr Thr Met Ser 
1               5   


<210>  167
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  167

Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu Gly 
1               5                   10                  15      


<210>  168
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  168

Arg Val Glu Gly Ser Phe Arg Gly 
1               5               


<210>  169
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  169

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  170
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  170

Arg Ala Ser Gln Ser Val Ser Thr Thr Tyr Leu Ala 
1               5                   10          


<210>  171
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  171

Gln Gln Tyr Gly Gly Ser Arg Leu Ile Thr 
1               5                   10  


<210>  172
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  172

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  173
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  173

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


<210>  174
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  174

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  175
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  175

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  176
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  176

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


<210>  177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  177

Glu Pro Lys Ser Cys Asp Lys Thr His Leu 
1               5                   10  


<210>  178
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  178

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  179
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  179

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  180
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  180

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210>  181
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  181

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  182
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  182

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala 
1               5                   10              


<210>  183
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  183

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu 
            20                  


<210>  184
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  184

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu 
            20                  


<210>  185
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  185

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  186
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  186

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  187
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain


<220>
<221>  misc
<222>  (227)..(230)
<223>  can be present or absent from the peptide

<220>
<221>  misc
<222>  (230)..(230)
<223>  Xaa can be threonine or lysine

<220>
<221>  misc
<222>  (231)..(236)
<223>  can be present or absent from the peptide

<220>
<221>  misc
<222>  (237)..(247)
<223>  can be present or absent from the peptide

<400>  187

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Xaa Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu 
                245         


<210>  188
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  188

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  189
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain


<220>
<221>  misc
<222>  (231)..(234)
<223>  can be present or absent from peptide

<220>
<221>  misc
<222>  (234)..(234)
<223>  Xaa can be threonine or lysine

<220>
<221>  misc
<222>  (235)..(240)
<223>  can be present or absent from peptide

<220>
<221>  misc
<222>  (241)..(251)
<223>  can be present or absent from peptide

<400>  189

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Xaa Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250     


<210>  190
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  190

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met 
        35                  40                  45              


Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn 
                85                  90                  95      


Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Cys Ser 
    210                 215 


<210>  191
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain


<220>
<221>  MISC
<222>  (221)..(224)
<223>  can be present or absent from peptide

<220>
<221>  MISC
<222>  (224)..(224)
<223>  Xaa can be threonine or lysine

<220>
<221>  MISC
<222>  (225)..(230)
<223>  can be present or absent from peptide

<220>
<221>  MISC
<222>  (231)..(241)
<223>  can be present or absent from peptide

<400>  191

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Xaa 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu 
    


<210>  192
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  192

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg 
                85                  90                  95      


Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  193
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  193

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  194
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  194

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val 
        


<210>  195
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  195

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  196
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  196

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  197
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  197

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  198
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  198

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        195                 200                 205 


<210>  199
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  199

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
1               5                   10                  15      


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            20                  25                  30          


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        35                  40                  45              


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    50                  55                  60                  


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
65                  70                  75                  80  


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                85                  90                  95      


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105     


<210>  200
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  200

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  201
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  201

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
1               5                   10                  15      


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            20                  25                  30          


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        35                  40                  45              


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    50                  55                  60                  


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
65                  70                  75                  80  


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                85                  90                  95      


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105     


<210>  202
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  202

Cys Pro Pro Cys Pro Ala 
1               5       


<210>  203
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  203

Cys Pro Pro Cys Pro 
1               5   


<210>  204
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  204

Cys Pro Pro Cys Ala 
1               5   


<210>  205
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  205

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly 
            20          


<210>  206
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  206

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  207
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  207

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  208
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  208

Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  209
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  209

Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  210
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  210

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210>  211
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  211

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala 
            20          


<210>  212
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  212

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu 
            20                  25          


<210>  213
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  213

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu 
            20                  25          


<210>  214
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  214

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly 
            20          


<210>  215
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  215

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  216
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  216

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  217
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; intron sequence

<400>  217
gtgagtatct cagggatcca gacatgggga tatgggaggt gcctctgatc ccagggctca       60

ctgtgggtct ctctgttcac ag                                                82


<210>  218
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; intron sequence

<400>  218
gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa       60

agaactgctc ctcagtggat gttgccttta cttctag                                97


<210>  219
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid

<400>  219

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Asp Gly Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  220
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid

<400>  220

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  221
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid

<400>  221

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Asp Gly Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  222
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid

<400>  222

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  223
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid

<400>  223

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Glu Ser Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  224
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid

<400>  224

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Gly Gly Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  225
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid

<400>  225

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Asp Gly Thr Leu Ala Thr 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  226
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  226

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  227
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  227

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  228
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  228

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  229
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge

<400>  229

Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


<210>  230
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  230

Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
1               5                   10                  15      


Pro Cys Lys Cys Pro 
            20      


<210>  231
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge

<400>  231

Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile 
1               5                   10                  15      


Lys Pro Cys Pro Pro Cys Lys Cys Pro 
            20                  25  


<210>  232
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; IgG construct

<400>  232

Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        35                  40                  45              


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
    50                  55                  60                  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
65                  70                  75                  80  


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
                85                  90                  95      


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
            100                 105                 110         


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
        115                 120                 125             


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
    130                 135                 140                 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
145                 150                 155                 160 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
                165                 170                 175     


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
            180                 185                 190         


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
        195                 200                 205             


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    210                 215         


<210>  233
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; IgG construct

<400>  233

Ala Pro Asn Ala Ala Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        35                  40                  45              


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
    50                  55                  60                  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
65                  70                  75                  80  


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
                85                  90                  95      


Asp Leu Gly Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
            100                 105                 110         


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
        115                 120                 125             


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
    130                 135                 140                 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
145                 150                 155                 160 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
                165                 170                 175     


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
            180                 185                 190         


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
        195                 200                 205             


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    210                 215         


<210>  234
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  234

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala 
    130                 135                 140                 


Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn 
145                 150                 155                 160 


Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
            180                 185                 190         


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr 
    210                 215                 220                 


Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
                245                 250                 255     


Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
        275                 280                 285             


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
    290                 295                 300                 


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
305                 310                 315                 320 


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
                325                 330                 335     


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
            340                 345                 350         


Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
        355                 360                 365             


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
    370                 375                 380                 


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
385                 390                 395                 400 


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
                405                 410                 415     


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
        435                 440                 445             


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
    450                 455                 460                 


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475             


<210>  235
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  235

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala 
    130                 135                 140                 


Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn 
145                 150                 155                 160 


Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
            180                 185                 190         


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr 
    210                 215                 220                 


Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys 
                245                 250                 255     


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
465                 470                 


<210>  236
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  236

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala 
    130                 135                 140                 


Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn 
145                 150                 155                 160 


Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
            180                 185                 190         


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr 
    210                 215                 220                 


Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr 
                245                 250                 255     


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
        275                 280                 285             


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
    290                 295                 300                 


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
305                 310                 315                 320 


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
                325                 330                 335     


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
            340                 345                 350         


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
    370                 375                 380                 


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
385                 390                 395                 400 


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
                405                 410                 415     


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
        435                 440                 445             


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
    450                 455                 460                 


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
465                 470                 475                 480 


Pro Gly Lys 
            


<210>  237
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  237

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala 
    130                 135                 140                 


Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn 
145                 150                 155                 160 


Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
            180                 185                 190         


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr 
    210                 215                 220                 


Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Gly Gly Gly Gly Gly Glu Ser Lys Tyr Gly Pro 
                245                 250                 255     


Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
    290                 295                 300                 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
465                 470                 475                 


<210>  238
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  238

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala 
    130                 135                 140                 


Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn 
145                 150                 155                 160 


Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
            180                 185                 190         


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr 
    210                 215                 220                 


Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Pro 
                245                 250                 255     


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
            260                 265                 270         


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
        275                 280                 285             


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
    290                 295                 300                 


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
305                 310                 315                 320 


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
                325                 330                 335     


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
            340                 345                 350         


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
        355                 360                 365             


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
    370                 375                 380                 


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
385                 390                 395                 400 


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
                405                 410                 415     


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
            420                 425                 430         


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
        435                 440                 445             


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
    450                 455                 460                 


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
465                 470                 475                 480 


Phe Ser Arg Thr Pro Gly Lys 
                485         


<210>  239
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  239

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala 
    130                 135                 140                 


Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn 
145                 150                 155                 160 


Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
            180                 185                 190         


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr 
    210                 215                 220                 


Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ser 
                245                 250                 255     


Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Leu Gly Lys 
            


<210>  240
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  240

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ala Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys 
145                 150                 155                 160 


Arg Ser Ser Gln Asn Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly 
    210                 215                 220                 


Asp Val Ala Val Tyr Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Pro Arg Gly Pro Thr 
                245                 250                 255     


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
        275                 280                 285             


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
    290                 295                 300                 


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
305                 310                 315                 320 


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
                325                 330                 335     


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
            340                 345                 350         


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
    370                 375                 380                 


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
385                 390                 395                 400 


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
                405                 410                 415     


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
        435                 440                 445             


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
    450                 455                 460                 


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
465                 470                 475                 480 


Pro Gly Lys 
            


<210>  241
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  241

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ala Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys 
145                 150                 155                 160 


Arg Ser Ser Gln Asn Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly 
    210                 215                 220                 


Asp Val Ala Val Tyr Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Gly Glu 
                245                 250                 255     


Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala 
            260                 265                 270         


Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile 
        275                 280                 285             


Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
305                 310                 315                 320 


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
                325                 330                 335     


Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln 
            340                 345                 350         


Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val 
    370                 375                 380                 


Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr 
385                 390                 395                 400 


Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu 
                405                 410                 415     


Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr 
            420                 425                 430         


Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 
        435                 440                 445             


Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr 
    450                 455                 460                 


Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys 
465                 470                 475                 480 


Ser Phe Ser Arg Thr Pro Gly Lys 
                485             


<210>  242
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  242

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ala Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys 
145                 150                 155                 160 


Arg Ser Ser Gln Asn Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly 
    210                 215                 220                 


Asp Val Ala Val Tyr Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys 
            260                 265                 270         


Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe 
        275                 280                 285             


Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val 
    290                 295                 300                 


Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile 
305                 310                 315                 320 


Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr 
                325                 330                 335     


His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro 
            340                 345                 350         


Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val 
        355                 360                 365             


Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro 
    370                 375                 380                 


Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu 
385                 390                 395                 400 


Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp 
                405                 410                 415     


Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr 
            420                 425                 430         


Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser 
        435                 440                 445             


Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu 
    450                 455                 460                 


Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His 
465                 470                 475                 480 


His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 490         


<210>  243
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  243

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    130                 135                 140                 


Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly Glu Arg 
145                 150                 155                 160 


Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn Ser Asn 
                165                 170                 175     


Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro 
            180                 185                 190         


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
        195                 200                 205             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
    210                 215                 220                 


Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln Tyr Phe 
225                 230                 235                 240 


Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu 
                245                 250                 255     


Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala 
            260                 265                 270         


Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile 
        275                 280                 285             


Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
305                 310                 315                 320 


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
                325                 330                 335     


Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln 
            340                 345                 350         


Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val 
    370                 375                 380                 


Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr 
385                 390                 395                 400 


Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu 
                405                 410                 415     


Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr 
            420                 425                 430         


Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 
        435                 440                 445             


Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr 
    450                 455                 460                 


Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys 
465                 470                 475                 480 


Ser Phe Ser Arg Thr Pro Gly Lys 
                485             


<210>  244
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  244

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    130                 135                 140                 


Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly Glu Arg 
145                 150                 155                 160 


Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn Ser Asn 
                165                 170                 175     


Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro 
            180                 185                 190         


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
        195                 200                 205             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
    210                 215                 220                 


Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln Tyr Phe 
225                 230                 235                 240 


Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly 
                245                 250                 255     


Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 
            260                 265                 270         


Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile 
        275                 280                 285             


Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln 
305                 310                 315                 320 


Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln 
                325                 330                 335     


Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu 
            340                 345                 350         


Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys 
        355                 360                 365             


Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys 
    370                 375                 380                 


Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro 
385                 390                 395                 400 


Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr 
                405                 410                 415     


Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys 
            420                 425                 430         


Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val 
    450                 455                 460                 


Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn 
465                 470                 475                 480 


His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 490             


<210>  245
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  245

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    130                 135                 140                 


Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly Glu Arg 
145                 150                 155                 160 


Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn Ser Asn 
                165                 170                 175     


Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro 
            180                 185                 190         


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
        195                 200                 205             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
    210                 215                 220                 


Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln Tyr Phe 
225                 230                 235                 240 


Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys 
            260                 265                 270         


Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro 
        275                 280                 285             


Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser 
    290                 295                 300                 


Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp 
305                 310                 315                 320 


Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr 
                325                 330                 335     


Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val 
            340                 345                 350         


Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu 
        355                 360                 365             


Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg 
    370                 375                 380                 


Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val 
385                 390                 395                 400 


Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr 
                405                 410                 415     


Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr 
            420                 425                 430         


Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys 
    450                 455                 460                 


Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu 
465                 470                 475                 480 


Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly 
                485                 490                 495     


Lys 
    


<210>  246
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  246

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
        115                 120                 125             


Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly Glu Arg Val Thr Ile 
    130                 135                 140                 


Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn Ser Asn Asn Lys Asn 
145                 150                 155                 160 


Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln 
        195                 200                 205             


Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln Tyr Phe Thr Asp Ala 
    210                 215                 220                 


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Pro Arg Gly 
225                 230                 235                 240 


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
            260                 265                 270         


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
    290                 295                 300                 


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
305                 310                 315                 320 


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
                325                 330                 335     


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
        355                 360                 365             


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
    370                 375                 380                 


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
385                 390                 395                 400 


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
                405                 410                 415     


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
            420                 425                 430         


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
        435                 440                 445             


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
    450                 455                 460                 


Arg Thr Pro Gly Lys 
465                 


<210>  247
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  247

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
        115                 120                 125             


Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly Glu Arg Val Thr Ile 
    130                 135                 140                 


Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn Ser Asn Asn Lys Asn 
145                 150                 155                 160 


Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln 
        195                 200                 205             


Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln Tyr Phe Thr Asp Ala 
    210                 215                 220                 


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
225                 230                 235                 240 


Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
                245                 250                 255     


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
            260                 265                 270         


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
    290                 295                 300                 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
305                 310                 315                 320 


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
                325                 330                 335     


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
            340                 345                 350         


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
        355                 360                 365             


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
    370                 375                 380                 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
385                 390                 395                 400 


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
                405                 410                 415     


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
            420                 425                 430         


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
        435                 440                 445             


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
    450                 455                 460                 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 


<210>  248
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  248

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
        115                 120                 125             


Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly Glu Arg Val Thr Ile 
    130                 135                 140                 


Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn Ser Asn Asn Lys Asn 
145                 150                 155                 160 


Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln 
        195                 200                 205             


Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln Tyr Phe Thr Asp Ala 
    210                 215                 220                 


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
225                 230                 235                 240 


Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
                245                 250                 255     


Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
        275                 280                 285             


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
    290                 295                 300                 


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
305                 310                 315                 320 


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
                325                 330                 335     


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
            340                 345                 350         


Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
        355                 360                 365             


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
    370                 375                 380                 


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
385                 390                 395                 400 


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
                405                 410                 415     


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
        435                 440                 445             


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
    450                 455                 460                 


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475             


<210>  249
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  249

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
    130                 135                 140                 


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
145                 150                 155                 160 


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
                165                 170                 175     


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
    210                 215                 220                 


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
                245                 250                 255     


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
            260                 265                 270         


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
    290                 295                 300                 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
305                 310                 315                 320 


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
                325                 330                 335     


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
            340                 345                 350         


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
        355                 360                 365             


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
    370                 375                 380                 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
385                 390                 395                 400 


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
                405                 410                 415     


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
            420                 425                 430         


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
        435                 440                 445             


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
    450                 455                 460                 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 


<210>  250
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  250

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
    130                 135                 140                 


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
145                 150                 155                 160 


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
                165                 170                 175     


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
    210                 215                 220                 


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys 
                245                 250                 255     


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
        275                 280                 285             


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
    290                 295                 300                 


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
305                 310                 315                 320 


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
                325                 330                 335     


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
            340                 345                 350         


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
        355                 360                 365             


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
    370                 375                 380                 


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
385                 390                 395                 400 


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
                405                 410                 415     


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
        435                 440                 445             


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
    450                 455                 460                 


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475                 


<210>  251
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  251

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
    130                 135                 140                 


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
145                 150                 155                 160 


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
                165                 170                 175     


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
    210                 215                 220                 


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr 
                245                 250                 255     


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
        275                 280                 285             


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
    290                 295                 300                 


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
305                 310                 315                 320 


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
                325                 330                 335     


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
            340                 345                 350         


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
    370                 375                 380                 


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
385                 390                 395                 400 


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
                405                 410                 415     


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
        435                 440                 445             


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
    450                 455                 460                 


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
465                 470                 475                 480 


Pro Gly Lys 
            


<210>  252
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  252

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu 
    130                 135                 140                 


Ala Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln 
145                 150                 155                 160 


Asn Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
            180                 185                 190         


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val 
    210                 215                 220                 


Tyr Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys 
                245                 250                 255     


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
        275                 280                 285             


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
    290                 295                 300                 


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
305                 310                 315                 320 


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
                325                 330                 335     


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
            340                 345                 350         


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
        355                 360                 365             


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
    370                 375                 380                 


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
385                 390                 395                 400 


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
                405                 410                 415     


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
        435                 440                 445             


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
    450                 455                 460                 


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475                 


<210>  253
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  253

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu 
    130                 135                 140                 


Ala Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln 
145                 150                 155                 160 


Asn Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
            180                 185                 190         


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val 
    210                 215                 220                 


Tyr Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro 
                245                 250                 255     


Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
        275                 280                 285             


Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu 
305                 310                 315                 320 


Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr 
                325                 330                 335     


Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
            340                 345                 350         


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln 
    370                 375                 380                 


Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val 
385                 390                 395                 400 


Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val 
                405                 410                 415     


Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg 
        435                 440                 445             


Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val 
    450                 455                 460                 


Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg 
465                 470                 475                 480 


Thr Pro Gly Lys 
                


<210>  254
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  254

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu 
    130                 135                 140                 


Ala Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln 
145                 150                 155                 160 


Asn Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
            180                 185                 190         


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val 
    210                 215                 220                 


Tyr Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu 
                245                 250                 255     


Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala 
            260                 265                 270         


Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile 
        275                 280                 285             


Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
305                 310                 315                 320 


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
                325                 330                 335     


Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln 
            340                 345                 350         


Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val 
    370                 375                 380                 


Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr 
385                 390                 395                 400 


Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu 
                405                 410                 415     


Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr 
            420                 425                 430         


Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 
        435                 440                 445             


Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr 
    450                 455                 460                 


Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys 
465                 470                 475                 480 


Ser Phe Ser Arg Thr Pro Gly Lys 
                485             


<210>  255
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  255

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro 
    130                 135                 140                 


Ser Leu Ser Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Leu 
145                 150                 155                 160 


Ser Ser Ala Ser Val Ser Thr Ser Ser Tyr Pro Ser Trp Tyr Gln Gln 
                165                 170                 175     


Thr Pro Gly Gln Pro Pro Arg Met Leu Ile His Asn Thr Asp Thr Arg 
            180                 185                 190         


Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Leu Gly Lys Lys 
        195                 200                 205             


Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp Asp Glu Ser Asp Tyr 
    210                 215                 220                 


Tyr Cys Val Val Tyr Leu Gly Asn Gly Phe Trp Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys 
                245                 250                 255     


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
        275                 280                 285             


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
    290                 295                 300                 


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
305                 310                 315                 320 


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
                325                 330                 335     


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
            340                 345                 350         


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
        355                 360                 365             


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
    370                 375                 380                 


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
385                 390                 395                 400 


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
                405                 410                 415     


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
        435                 440                 445             


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
    450                 455                 460                 


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475                 


<210>  256
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  256

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro 
    130                 135                 140                 


Ser Leu Ser Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Leu 
145                 150                 155                 160 


Ser Ser Ala Ser Val Ser Thr Ser Ser Tyr Pro Ser Trp Tyr Gln Gln 
                165                 170                 175     


Thr Pro Gly Gln Pro Pro Arg Met Leu Ile His Asn Thr Asp Thr Arg 
            180                 185                 190         


Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Leu Gly Lys Lys 
        195                 200                 205             


Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp Asp Glu Ser Asp Tyr 
    210                 215                 220                 


Tyr Cys Val Val Tyr Leu Gly Asn Gly Phe Trp Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser 
                245                 250                 255     


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
465                 470                 475 


<210>  257
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  257

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro 
    130                 135                 140                 


Ser Leu Ser Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Leu 
145                 150                 155                 160 


Ser Ser Ala Ser Val Ser Thr Ser Ser Tyr Pro Ser Trp Tyr Gln Gln 
                165                 170                 175     


Thr Pro Gly Gln Pro Pro Arg Met Leu Ile His Asn Thr Asp Thr Arg 
            180                 185                 190         


Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Leu Gly Lys Lys 
        195                 200                 205             


Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp Asp Glu Ser Asp Tyr 
    210                 215                 220                 


Tyr Cys Val Val Tyr Leu Gly Asn Gly Phe Trp Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro 
                245                 250                 255     


Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
        275                 280                 285             


Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu 
305                 310                 315                 320 


Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr 
                325                 330                 335     


Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
            340                 345                 350         


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln 
    370                 375                 380                 


Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val 
385                 390                 395                 400 


Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val 
                405                 410                 415     


Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg 
        435                 440                 445             


Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val 
    450                 455                 460                 


Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg 
465                 470                 475                 480 


Thr Pro Gly Lys 
                


<210>  258
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  258

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro 
    130                 135                 140                 


Ser Leu Ser Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Leu 
145                 150                 155                 160 


Ser Ser Ala Ser Val Ser Thr Ser Ser Tyr Pro Ser Trp Tyr Gln Gln 
                165                 170                 175     


Thr Pro Gly Gln Pro Pro Arg Met Leu Ile His Asn Thr Asp Thr Arg 
            180                 185                 190         


Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Leu Gly Lys Lys 
        195                 200                 205             


Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp Asp Glu Ser Asp Tyr 
    210                 215                 220                 


Tyr Cys Val Val Tyr Leu Gly Asn Gly Phe Trp Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Glu Ser Lys Tyr Gly 
                245                 250                 255     


Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
            260                 265                 270         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        275                 280                 285             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
    290                 295                 300                 


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
305                 310                 315                 320 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
                325                 330                 335     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            340                 345                 350         


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
        355                 360                 365             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    370                 375                 380                 


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
385                 390                 395                 400 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                405                 410                 415     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            420                 425                 430         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
        435                 440                 445             


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    450                 455                 460                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
465                 470                 475                 480 


<210>  259
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  259

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro 
    130                 135                 140                 


Ser Leu Ser Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Leu 
145                 150                 155                 160 


Ser Ser Ala Ser Val Ser Thr Ser Ser Tyr Pro Ser Trp Tyr Gln Gln 
                165                 170                 175     


Thr Pro Gly Gln Pro Pro Arg Met Leu Ile His Asn Thr Asp Thr Arg 
            180                 185                 190         


Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Leu Gly Lys Lys 
        195                 200                 205             


Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp Asp Glu Ser Asp Tyr 
    210                 215                 220                 


Tyr Cys Val Val Tyr Leu Gly Asn Gly Phe Trp Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu 
                245                 250                 255     


Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala 
            260                 265                 270         


Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile 
        275                 280                 285             


Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
305                 310                 315                 320 


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
                325                 330                 335     


Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln 
            340                 345                 350         


Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val 
    370                 375                 380                 


Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr 
385                 390                 395                 400 


Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu 
                405                 410                 415     


Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr 
            420                 425                 430         


Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 
        435                 440                 445             


Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr 
    450                 455                 460                 


Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys 
465                 470                 475                 480 


Ser Phe Ser Arg Thr Pro Gly Lys 
                485             


<210>  260
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  260

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro 
    130                 135                 140                 


Ser Leu Ser Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Leu 
145                 150                 155                 160 


Ser Ser Ala Ser Val Ser Thr Ser Ser Tyr Pro Ser Trp Tyr Gln Gln 
                165                 170                 175     


Thr Pro Gly Gln Pro Pro Arg Met Leu Ile His Asn Thr Asp Thr Arg 
            180                 185                 190         


Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Leu Gly Lys Lys 
        195                 200                 205             


Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp Asp Glu Ser Asp Tyr 
    210                 215                 220                 


Tyr Cys Val Val Tyr Leu Gly Asn Gly Phe Trp Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu 
                245                 250                 255     


Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Leu Gly Lys 
                


<210>  261
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  261

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val 
    130                 135                 140                 


Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly Thr Val Thr 
145                 150                 155                 160 


Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser Ser Tyr Pro 
                165                 170                 175     


Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met Leu Ile His 
            180                 185                 190         


Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp 
    210                 215                 220                 


Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn Gly Phe Trp 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Glu Pro Arg Gly Pro 
                245                 250                 255     


Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
        275                 280                 285             


Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu 
305                 310                 315                 320 


Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr 
                325                 330                 335     


Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
            340                 345                 350         


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln 
    370                 375                 380                 


Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val 
385                 390                 395                 400 


Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val 
                405                 410                 415     


Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg 
        435                 440                 445             


Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val 
    450                 455                 460                 


Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg 
465                 470                 475                 480 


Thr Pro Gly Lys 
                


<210>  262
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  262

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val 
    130                 135                 140                 


Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly Thr Val Thr 
145                 150                 155                 160 


Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser Ser Tyr Pro 
                165                 170                 175     


Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met Leu Ile His 
            180                 185                 190         


Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp 
    210                 215                 220                 


Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn Gly Phe Trp 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly 
                245                 250                 255     


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
            260                 265                 270         


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
        275                 280                 285             


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
    290                 295                 300                 


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
305                 310                 315                 320 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
                325                 330                 335     


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
            340                 345                 350         


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
        355                 360                 365             


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
    370                 375                 380                 


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
385                 390                 395                 400 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
                405                 410                 415     


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
            420                 425                 430         


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
        435                 440                 445             


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
    450                 455                 460                 


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
465                 470                 475                 480 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 


<210>  263
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  263

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val 
    130                 135                 140                 


Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly Thr Val Thr 
145                 150                 155                 160 


Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser Ser Tyr Pro 
                165                 170                 175     


Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met Leu Ile His 
            180                 185                 190         


Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp 
    210                 215                 220                 


Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn Gly Phe Trp 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 
            260                 265                 270         


Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile 
        275                 280                 285             


Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln 
305                 310                 315                 320 


Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln 
                325                 330                 335     


Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu 
            340                 345                 350         


Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys 
        355                 360                 365             


Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys 
    370                 375                 380                 


Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro 
385                 390                 395                 400 


Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr 
                405                 410                 415     


Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys 
            420                 425                 430         


Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val 
    450                 455                 460                 


Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn 
465                 470                 475                 480 


His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 490             


<210>  264
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  264

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro 
145                 150                 155                 160 


Gly Gly Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser 
                165                 170                 175     


Thr Ser Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro 
            180                 185                 190         


Arg Met Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp 
        195                 200                 205             


Arg Phe Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr 
    210                 215                 220                 


Gly Ala Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu 
225                 230                 235                 240 


Gly Asn Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250                 255     


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
            260                 265                 270         


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
        275                 280                 285             


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
    290                 295                 300                 


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
305                 310                 315                 320 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
                325                 330                 335     


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
            340                 345                 350         


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
        355                 360                 365             


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
    370                 375                 380                 


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
385                 390                 395                 400 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
                405                 410                 415     


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
            420                 425                 430         


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
        435                 440                 445             


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
    450                 455                 460                 


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
465                 470                 475                 480 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 


<210>  265
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  265

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro 
145                 150                 155                 160 


Gly Gly Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser 
                165                 170                 175     


Thr Ser Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro 
            180                 185                 190         


Arg Met Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp 
        195                 200                 205             


Arg Phe Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr 
    210                 215                 220                 


Gly Ala Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu 
225                 230                 235                 240 


Gly Asn Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250                 255     


Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
            260                 265                 270         


Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
    290                 295                 300                 


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
305                 310                 315                 320 


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
                325                 330                 335     


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
            340                 345                 350         


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
        355                 360                 365             


Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
    370                 375                 380                 


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
385                 390                 395                 400 


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
                405                 410                 415     


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
            420                 425                 430         


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
    450                 455                 460                 


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
465                 470                 475                 480 


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 490                 


<210>  266
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  266

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro 
145                 150                 155                 160 


Gly Gly Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser 
                165                 170                 175     


Thr Ser Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro 
            180                 185                 190         


Arg Met Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp 
        195                 200                 205             


Arg Phe Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr 
    210                 215                 220                 


Gly Ala Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu 
225                 230                 235                 240 


Gly Asn Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile 
            260                 265                 270         


Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
    290                 295                 300                 


Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
305                 310                 315                 320 


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
                325                 330                 335     


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
            340                 345                 350         


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
        355                 360                 365             


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr 
385                 390                 395                 400 


Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu 
                405                 410                 415     


Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
            420                 425                 430         


Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu 
    450                 455                 460                 


Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His 
465                 470                 475                 480 


Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro 
                485                 490                 495     


Gly Lys 
        


<210>  267
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  267

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met 
        35                  40                  45              


Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn 
                85                  90                  95      


Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly 
        115                 120                 125             


Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala 
    130                 135                 140                 


Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met His Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Leu Thr Leu Ile Ser Tyr Asn Gly Val 
                165                 170                 175     


Asn Lys Tyr Tyr Ala Lys Ser Val Lys Gly Arg Phe Ala Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Ser Thr Leu Phe Leu Gln Met Asn Ser Leu Thr Thr 
        195                 200                 205             


Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Cys Pro Ile Pro Arg Ala 
    210                 215                 220                 


Ala Ser Tyr Arg Asn Gly Asp Asn Tyr Phe Glu Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys 
                245                 250                 255     


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
        275                 280                 285             


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
    290                 295                 300                 


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
305                 310                 315                 320 


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
                325                 330                 335     


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
            340                 345                 350         


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
        355                 360                 365             


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
    370                 375                 380                 


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
385                 390                 395                 400 


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
                405                 410                 415     


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
        435                 440                 445             


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
    450                 455                 460                 


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475                 


<210>  268
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  268

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met 
        35                  40                  45              


Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn 
                85                  90                  95      


Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly 
        115                 120                 125             


Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala 
    130                 135                 140                 


Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met His Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Leu Thr Leu Ile Ser Tyr Asn Gly Val 
                165                 170                 175     


Asn Lys Tyr Tyr Ala Lys Ser Val Lys Gly Arg Phe Ala Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Ser Thr Leu Phe Leu Gln Met Asn Ser Leu Thr Thr 
        195                 200                 205             


Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Cys Pro Ile Pro Arg Ala 
    210                 215                 220                 


Ala Ser Tyr Arg Asn Gly Asp Asn Tyr Phe Glu Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro 
                245                 250                 255     


Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
        275                 280                 285             


Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu 
305                 310                 315                 320 


Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr 
                325                 330                 335     


Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
            340                 345                 350         


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln 
    370                 375                 380                 


Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val 
385                 390                 395                 400 


Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val 
                405                 410                 415     


Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg 
        435                 440                 445             


Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val 
    450                 455                 460                 


Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg 
465                 470                 475                 480 


Thr Pro Gly Lys 
                


<210>  269
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  269

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met 
        35                  40                  45              


Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn 
                85                  90                  95      


Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly 
        115                 120                 125             


Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala 
    130                 135                 140                 


Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met His Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Leu Thr Leu Ile Ser Tyr Asn Gly Val 
                165                 170                 175     


Asn Lys Tyr Tyr Ala Lys Ser Val Lys Gly Arg Phe Ala Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Ser Thr Leu Phe Leu Gln Met Asn Ser Leu Thr Thr 
        195                 200                 205             


Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Cys Pro Ile Pro Arg Ala 
    210                 215                 220                 


Ala Ser Tyr Arg Asn Gly Asp Asn Tyr Phe Glu Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu 
                245                 250                 255     


Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala 
            260                 265                 270         


Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile 
        275                 280                 285             


Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
305                 310                 315                 320 


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
                325                 330                 335     


Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln 
            340                 345                 350         


Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val 
    370                 375                 380                 


Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr 
385                 390                 395                 400 


Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu 
                405                 410                 415     


Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr 
            420                 425                 430         


Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 
        435                 440                 445             


Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr 
    450                 455                 460                 


Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys 
465                 470                 475                 480 


Ser Phe Ser Arg Thr Pro Gly Lys 
                485             


<210>  270
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  270

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met 
        35                  40                  45              


Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn 
                85                  90                  95      


Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met His 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Thr Leu Ile 
                165                 170                 175     


Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Cys 
    210                 215                 220                 


Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn Tyr Phe Glu 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Arg Gly Pro 
                245                 250                 255     


Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
        275                 280                 285             


Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu 
305                 310                 315                 320 


Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr 
                325                 330                 335     


Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
            340                 345                 350         


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln 
    370                 375                 380                 


Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val 
385                 390                 395                 400 


Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val 
                405                 410                 415     


Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg 
        435                 440                 445             


Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val 
    450                 455                 460                 


Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg 
465                 470                 475                 480 


Thr Pro Gly Lys 
                


<210>  271
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  271

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met 
        35                  40                  45              


Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn 
                85                  90                  95      


Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met His 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Thr Leu Ile 
                165                 170                 175     


Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Cys 
    210                 215                 220                 


Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn Tyr Phe Glu 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Gly 
                245                 250                 255     


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
            260                 265                 270         


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
        275                 280                 285             


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
    290                 295                 300                 


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
305                 310                 315                 320 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
                325                 330                 335     


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
            340                 345                 350         


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
        355                 360                 365             


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
    370                 375                 380                 


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
385                 390                 395                 400 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
                405                 410                 415     


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
            420                 425                 430         


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
        435                 440                 445             


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
    450                 455                 460                 


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
465                 470                 475                 480 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 


<210>  272
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  272

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met 
        35                  40                  45              


Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn 
                85                  90                  95      


Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met His 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Thr Leu Ile 
                165                 170                 175     


Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Cys 
    210                 215                 220                 


Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn Tyr Phe Glu 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 
            260                 265                 270         


Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile 
        275                 280                 285             


Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln 
305                 310                 315                 320 


Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln 
                325                 330                 335     


Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu 
            340                 345                 350         


Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys 
        355                 360                 365             


Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys 
    370                 375                 380                 


Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro 
385                 390                 395                 400 


Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr 
                405                 410                 415     


Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys 
            420                 425                 430         


Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val 
    450                 455                 460                 


Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn 
465                 470                 475                 480 


His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 490             


<210>  273
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  273

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met 
        35                  40                  45              


Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn 
                85                  90                  95      


Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Ser Tyr Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys 
            180                 185                 190         


Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
        195                 200                 205             


Leu Phe Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly 
225                 230                 235                 240 


Asp Asn Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
            260                 265                 270         


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
        275                 280                 285             


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
    290                 295                 300                 


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
305                 310                 315                 320 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
                325                 330                 335     


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
            340                 345                 350         


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
        355                 360                 365             


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
    370                 375                 380                 


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
385                 390                 395                 400 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
                405                 410                 415     


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
            420                 425                 430         


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
        435                 440                 445             


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
    450                 455                 460                 


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
465                 470                 475                 480 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 


<210>  274
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  274

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met 
        35                  40                  45              


Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn 
                85                  90                  95      


Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Ser Tyr Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys 
            180                 185                 190         


Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
        195                 200                 205             


Leu Phe Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly 
225                 230                 235                 240 


Asp Asn Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
            260                 265                 270         


Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
    290                 295                 300                 


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
305                 310                 315                 320 


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
                325                 330                 335     


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
            340                 345                 350         


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
        355                 360                 365             


Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
    370                 375                 380                 


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
385                 390                 395                 400 


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
                405                 410                 415     


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
            420                 425                 430         


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
    450                 455                 460                 


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
465                 470                 475                 480 


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 490                 


<210>  275
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  275

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met 
        35                  40                  45              


Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn 
                85                  90                  95      


Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Ser Tyr Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys 
            180                 185                 190         


Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
        195                 200                 205             


Leu Phe Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly 
225                 230                 235                 240 


Asp Asn Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile 
            260                 265                 270         


Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
    290                 295                 300                 


Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
305                 310                 315                 320 


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
                325                 330                 335     


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
            340                 345                 350         


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
        355                 360                 365             


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr 
385                 390                 395                 400 


Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu 
                405                 410                 415     


Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
            420                 425                 430         


Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu 
    450                 455                 460                 


Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His 
465                 470                 475                 480 


Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro 
                485                 490                 495     


Gly Lys 
        


<210>  276
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  276

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
        115                 120                 125             


Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Ser 
    130                 135                 140                 


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr Tyr Leu 
145                 150                 155                 160 


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
                165                 170                 175     


Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
        195                 200                 205             


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg Leu Ile 
    210                 215                 220                 


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Glu Pro Arg Gly Pro 
225                 230                 235                 240 


Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
            260                 265                 270         


Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu 
    290                 295                 300                 


Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr 
305                 310                 315                 320 


Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
                325                 330                 335     


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln 
        355                 360                 365             


Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val 
    370                 375                 380                 


Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val 
385                 390                 395                 400 


Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg 
            420                 425                 430         


Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val 
        435                 440                 445             


Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg 
    450                 455                 460                 


Thr Pro Gly Lys 
465             


<210>  277
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  277

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
        115                 120                 125             


Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Ser 
    130                 135                 140                 


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr Tyr Leu 
145                 150                 155                 160 


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
                165                 170                 175     


Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
        195                 200                 205             


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg Leu Ile 
    210                 215                 220                 


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Glu Ser Lys Tyr Gly 
225                 230                 235                 240 


Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460                 


<210>  278
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  278

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
        115                 120                 125             


Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Ser 
    130                 135                 140                 


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr Tyr Leu 
145                 150                 155                 160 


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
                165                 170                 175     


Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
        195                 200                 205             


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg Leu Ile 
    210                 215                 220                 


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Gly 
225                 230                 235                 240 


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
                245                 250                 255     


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            260                 265                 270         


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
305                 310                 315                 320 


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                325                 330                 335     


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            340                 345                 350         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        355                 360                 365             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    370                 375                 380                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
385                 390                 395                 400 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                405                 410                 415     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            420                 425                 430         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        435                 440                 445             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    450                 455                 460                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470             


<210>  279
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  279

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
        115                 120                 125             


Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Ser 
    130                 135                 140                 


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr Tyr Leu 
145                 150                 155                 160 


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
                165                 170                 175     


Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
        195                 200                 205             


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg Leu Ile 
    210                 215                 220                 


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Gly 
225                 230                 235                 240 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Leu Gly Lys 
465                 


<210>  280
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  280

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
        115                 120                 125             


Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Ser 
    130                 135                 140                 


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr Tyr Leu 
145                 150                 155                 160 


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
                165                 170                 175     


Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
        195                 200                 205             


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg Leu Ile 
    210                 215                 220                 


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Gly 
225                 230                 235                 240 


Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 
                245                 250                 255     


Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile 
            260                 265                 270         


Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln 
    290                 295                 300                 


Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln 
305                 310                 315                 320 


Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu 
                325                 330                 335     


Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys 
            340                 345                 350         


Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys 
        355                 360                 365             


Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro 
    370                 375                 380                 


Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr 
385                 390                 395                 400 


Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys 
                405                 410                 415     


Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val 
        435                 440                 445             


Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn 
    450                 455                 460                 


His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475         


<210>  281
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  281

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
        115                 120                 125             


Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Ser 
    130                 135                 140                 


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr Tyr Leu 
145                 150                 155                 160 


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
                165                 170                 175     


Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
        195                 200                 205             


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg Leu Ile 
    210                 215                 220                 


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Gly 
225                 230                 235                 240 


Gly Gly Gly Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
                245                 250                 255     


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
465                 470             


<210>  282
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  282

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu 
    130                 135                 140                 


Ser Pro Gly Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
145                 150                 155                 160 


Ser Thr Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
                165                 170                 175     


Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly 
    210                 215                 220                 


Gly Ser Arg Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
225                 230                 235                 240 


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
                245                 250                 255     


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            260                 265                 270         


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
305                 310                 315                 320 


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                325                 330                 335     


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            340                 345                 350         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        355                 360                 365             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    370                 375                 380                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
385                 390                 395                 400 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                405                 410                 415     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            420                 425                 430         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        435                 440                 445             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    450                 455                 460                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470             


<210>  283
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  283

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu 
    130                 135                 140                 


Ser Pro Gly Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
145                 150                 155                 160 


Ser Thr Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
                165                 170                 175     


Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly 
    210                 215                 220                 


Gly Ser Arg Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
225                 230                 235                 240 


Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
                245                 250                 255     


Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
        275                 280                 285             


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
    290                 295                 300                 


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
305                 310                 315                 320 


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
                325                 330                 335     


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
            340                 345                 350         


Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
        355                 360                 365             


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
    370                 375                 380                 


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
385                 390                 395                 400 


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
                405                 410                 415     


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
        435                 440                 445             


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
    450                 455                 460                 


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475             


<210>  284
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  284

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu 
    130                 135                 140                 


Ser Pro Gly Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
145                 150                 155                 160 


Ser Thr Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
                165                 170                 175     


Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly 
    210                 215                 220                 


Gly Ser Arg Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
225                 230                 235                 240 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile 
                245                 250                 255     


Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
        275                 280                 285             


Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
    290                 295                 300                 


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
305                 310                 315                 320 


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
                325                 330                 335     


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
            340                 345                 350         


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr 
    370                 375                 380                 


Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu 
385                 390                 395                 400 


Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
                405                 410                 415     


Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu 
        435                 440                 445             


Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His 
    450                 455                 460                 


Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro 
465                 470                 475                 480 


Gly Lys 
        


<210>  285
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  285

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Gly Thr Leu Ser Leu Ser Pro Gly Glu Ser Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Thr Thr Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala 
            180                 185                 190         


Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Tyr Gly Gly Ser Arg Leu Ile Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Arg Leu Glu Ile Lys Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
                245                 250                 255     


Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
        275                 280                 285             


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
    290                 295                 300                 


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
305                 310                 315                 320 


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
                325                 330                 335     


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
            340                 345                 350         


Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
        355                 360                 365             


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
    370                 375                 380                 


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
385                 390                 395                 400 


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
                405                 410                 415     


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
        435                 440                 445             


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
    450                 455                 460                 


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475             


<210>  286
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  286

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Gly Thr Leu Ser Leu Ser Pro Gly Glu Ser Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Thr Thr Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala 
            180                 185                 190         


Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Tyr Gly Gly Ser Arg Leu Ile Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Arg Leu Glu Ile Lys Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr 
                245                 250                 255     


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
        275                 280                 285             


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
    290                 295                 300                 


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
305                 310                 315                 320 


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
                325                 330                 335     


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
            340                 345                 350         


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
    370                 375                 380                 


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
385                 390                 395                 400 


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
                405                 410                 415     


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
        435                 440                 445             


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
    450                 455                 460                 


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
465                 470                 475                 480 


Pro Gly Lys 
            


<210>  287
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  287

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Gly Thr Leu Ser Leu Ser Pro Gly Glu Ser Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Thr Thr Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala 
            180                 185                 190         


Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Tyr Gly Gly Ser Arg Leu Ile Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Arg Leu Glu Ile Lys Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Pro 
                245                 250                 255     


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
            260                 265                 270         


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
        275                 280                 285             


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
    290                 295                 300                 


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
305                 310                 315                 320 


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
                325                 330                 335     


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
            340                 345                 350         


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
        355                 360                 365             


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
    370                 375                 380                 


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
385                 390                 395                 400 


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
                405                 410                 415     


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
            420                 425                 430         


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
        435                 440                 445             


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
    450                 455                 460                 


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
465                 470                 475                 480 


Phe Ser Arg Thr Pro Gly Lys 
                485         


<210>  288
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  288

Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu 
1               5                   10                  15      


Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg Leu 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Ser Ile Tyr Thr Met Ser Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr 
                165                 170                 175     


Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
            180                 185                 190         


Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr 
        195                 200                 205             


Ala Val Tyr Tyr Cys Thr Lys Arg Val Glu Gly Ser Phe Arg Gly Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Arg Gly Pro Thr 
225                 230                 235                 240 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
            260                 265                 270         


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
        275                 280                 285             


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
    290                 295                 300                 


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
305                 310                 315                 320 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
    370                 375                 380                 


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
385                 390                 395                 400 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
            420                 425                 430         


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
        435                 440                 445             


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  289
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  289

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg 
                85                  90                  95      


Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Thr Phe Ser Ile Tyr Thr Met Ser Trp Val Arg Gln Ala Pro 
145                 150                 155                 160 


Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Ser Asp Gly Ser Thr 
                165                 170                 175     


Tyr Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            180                 185                 190         


Ser Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Thr Ala Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Thr Lys Arg Val Glu Gly Ser Phe Arg Gly 
    210                 215                 220                 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Gly 
225                 230                 235                 240 


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
                245                 250                 255     


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            260                 265                 270         


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
305                 310                 315                 320 


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                325                 330                 335     


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            340                 345                 350         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        355                 360                 365             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    370                 375                 380                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
385                 390                 395                 400 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                405                 410                 415     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            420                 425                 430         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        435                 440                 445             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    450                 455                 460                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470             


<210>  290
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  290

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg 
                85                  90                  95      


Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Thr Phe Ser Ile Tyr Thr Met Ser Trp Val Arg Gln Ala Pro 
145                 150                 155                 160 


Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Ser Asp Gly Ser Thr 
                165                 170                 175     


Tyr Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            180                 185                 190         


Ser Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Thr Ala Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Thr Lys Arg Val Glu Gly Ser Phe Arg Gly 
    210                 215                 220                 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Gly 
225                 230                 235                 240 


Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 
                245                 250                 255     


Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile 
            260                 265                 270         


Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln 
    290                 295                 300                 


Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln 
305                 310                 315                 320 


Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu 
                325                 330                 335     


Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys 
            340                 345                 350         


Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys 
        355                 360                 365             


Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro 
    370                 375                 380                 


Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr 
385                 390                 395                 400 


Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys 
                405                 410                 415     


Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val 
        435                 440                 445             


Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn 
    450                 455                 460                 


His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475         


<210>  291
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  291

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg 
                85                  90                  95      


Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr Thr Met Ser Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Leu 
                165                 170                 175     


Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Lys Arg Val Glu 
    210                 215                 220                 


Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
                245                 250                 255     


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            260                 265                 270         


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
305                 310                 315                 320 


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                325                 330                 335     


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            340                 345                 350         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        355                 360                 365             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    370                 375                 380                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
385                 390                 395                 400 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                405                 410                 415     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            420                 425                 430         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        435                 440                 445             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    450                 455                 460                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470             


<210>  292
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  292

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg 
                85                  90                  95      


Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr Thr Met Ser Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Leu 
                165                 170                 175     


Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Lys Arg Val Glu 
    210                 215                 220                 


Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
                245                 250                 255     


Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
        275                 280                 285             


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
    290                 295                 300                 


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
305                 310                 315                 320 


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
                325                 330                 335     


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
            340                 345                 350         


Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
        355                 360                 365             


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
    370                 375                 380                 


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
385                 390                 395                 400 


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
                405                 410                 415     


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
        435                 440                 445             


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
    450                 455                 460                 


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475             


<210>  293
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  293

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg 
                85                  90                  95      


Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr Thr Met Ser Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Leu 
                165                 170                 175     


Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Lys Arg Val Glu 
    210                 215                 220                 


Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile 
                245                 250                 255     


Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
        275                 280                 285             


Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
    290                 295                 300                 


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
305                 310                 315                 320 


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
                325                 330                 335     


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
            340                 345                 350         


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr 
    370                 375                 380                 


Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu 
385                 390                 395                 400 


Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
                405                 410                 415     


Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu 
        435                 440                 445             


Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His 
    450                 455                 460                 


Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro 
465                 470                 475                 480 


Gly Lys 
        


<210>  294
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  294

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg 
                85                  90                  95      


Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile 
145                 150                 155                 160 


Tyr Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
            180                 185                 190         


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Thr Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
                245                 250                 255     


Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
        275                 280                 285             


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
    290                 295                 300                 


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
305                 310                 315                 320 


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
                325                 330                 335     


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
            340                 345                 350         


Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
        355                 360                 365             


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
    370                 375                 380                 


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
385                 390                 395                 400 


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
                405                 410                 415     


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
        435                 440                 445             


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
    450                 455                 460                 


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475             


<210>  295
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  295

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg 
                85                  90                  95      


Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile 
145                 150                 155                 160 


Tyr Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
            180                 185                 190         


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Thr Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr 
                245                 250                 255     


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
        275                 280                 285             


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
    290                 295                 300                 


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
305                 310                 315                 320 


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
                325                 330                 335     


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
            340                 345                 350         


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
    370                 375                 380                 


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
385                 390                 395                 400 


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
                405                 410                 415     


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
        435                 440                 445             


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
    450                 455                 460                 


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
465                 470                 475                 480 


Pro Gly Lys 
            


<210>  296
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  296

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg 
                85                  90                  95      


Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile 
145                 150                 155                 160 


Tyr Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
            180                 185                 190         


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Thr Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Pro 
                245                 250                 255     


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
            260                 265                 270         


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
        275                 280                 285             


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
    290                 295                 300                 


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
305                 310                 315                 320 


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
                325                 330                 335     


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
            340                 345                 350         


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
        355                 360                 365             


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
    370                 375                 380                 


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
385                 390                 395                 400 


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
                405                 410                 415     


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
            420                 425                 430         


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
        435                 440                 445             


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
    450                 455                 460                 


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
465                 470                 475                 480 


Phe Ser Arg Thr Pro Gly Lys 
                485         


<210>  297
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  297

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
        115                 120                 125             


Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Ser 
    130                 135                 140                 


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr Tyr Leu 
145                 150                 155                 160 


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
                165                 170                 175     


Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
        195                 200                 205             


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg Leu Ile 
    210                 215                 220                 


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
225                 230                 235 


<210>  298
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  298

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu 
    130                 135                 140                 


Ser Pro Gly Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
145                 150                 155                 160 


Ser Thr Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
                165                 170                 175     


Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly 
    210                 215                 220                 


Gly Ser Arg Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
225                 230                 235                 240 


<210>  299
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  299

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Gly Thr Leu Ser Leu Ser Pro Gly Glu Ser Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Thr Thr Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala 
            180                 185                 190         


Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Tyr Gly Gly Ser Arg Leu Ile Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Arg Leu Glu Ile Lys 
                245 


<210>  300
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  300

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro 
    130                 135                 140                 


Ser Leu Ser Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Leu 
145                 150                 155                 160 


Ser Ser Ala Ser Val Ser Thr Ser Ser Tyr Pro Ser Trp Tyr Gln Gln 
                165                 170                 175     


Thr Pro Gly Gln Pro Pro Arg Met Leu Ile His Asn Thr Asp Thr Arg 
            180                 185                 190         


Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Leu Gly Lys Lys 
        195                 200                 205             


Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp Asp Glu Ser Asp Tyr 
    210                 215                 220                 


Tyr Cys Val Val Tyr Leu Gly Asn Gly Phe Trp Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu 
                245     


<210>  301
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  301

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val 
    130                 135                 140                 


Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly Thr Val Thr 
145                 150                 155                 160 


Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser Ser Tyr Pro 
                165                 170                 175     


Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met Leu Ile His 
            180                 185                 190         


Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp 
    210                 215                 220                 


Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn Gly Phe Trp 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  302
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  302

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro 
145                 150                 155                 160 


Gly Gly Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser 
                165                 170                 175     


Thr Ser Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro 
            180                 185                 190         


Arg Met Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp 
        195                 200                 205             


Arg Phe Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr 
    210                 215                 220                 


Gly Ala Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu 
225                 230                 235                 240 


Gly Asn Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250                 255     


<210>  303
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  303

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala 
    130                 135                 140                 


Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn 
145                 150                 155                 160 


Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
            180                 185                 190         


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr 
    210                 215                 220                 


Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  304
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  304

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ala Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys 
145                 150                 155                 160 


Arg Ser Ser Gln Asn Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly 
    210                 215                 220                 


Asp Val Ala Val Tyr Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  305
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  305

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    130                 135                 140                 


Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly Glu Arg 
145                 150                 155                 160 


Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn Ser Asn 
                165                 170                 175     


Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro 
            180                 185                 190         


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
        195                 200                 205             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
    210                 215                 220                 


Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln Tyr Phe 
225                 230                 235                 240 


Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250                 255 


<210>  306
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  306
gaggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctggggagag cctgaagatc       60

agctgcaaag tgtctggcta tgacttcagc aagtactgga ttggctgggt cagacagatg      120

cctggcaaag gcctggaatg gatgggactg atctaccctg gggactctga caccagatac      180

agccctagcc tggaaggcca ggtgtccatc tctgctgaca agagcatctc tgcagcctac      240

ctgcagttca gcagcctgaa ggcctctgac tctgccatgt actactgtgt cagaaagggc      300

tactctgcct accttggagg atggtttgat ccttggggcc agggcacact ggtcacagtg      360

tcctct                                                                 366


<210>  307
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  307
gacatccagc tgacacagag ccctgacagc ctggctgctt ctctgggaga gagagtgacc       60

atcaactgca gaagctccca gaacatcttc tacaacagca acaacaagaa cttcctggcc      120

tggtatcagc agaaggctgg ccagtctcct aagctgctga tctactgggc cagcaccaga      180

gaatctgggg tgccagatag attttctggc agtggctctg gcacagactt caccctgaca      240

atcagtggac tgcaggctgg ggatgttgct gtgtacttct gccagcagta cttcacagat      300

gcccctacct ttggtggtgg caccaaggtg gaaatcaag                             339


<210>  308
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  308
gaggtgcagc tgctgcagag tggtggtggt gttgtgcagc ctggtggctc tctgagactg       60

tcttgtgaag cctctggctt caccttcagc agctacagca tgcactgggt cagacaggcc      120

cctggcaaag gactggaatg gctgaccctg atcagctaca atggggtcaa caagtactat      180

gccaagtctg tgaagggcag atttgccatc agcagagatg acagcaagtc taccctgttc      240

ctgcagatga acagcctgac cacagatgac actgctgtgt actactgtgc cagatgtccc      300

attcctagag ctgccagcta cagaaatggg gacaactact ttgagtttgg ccagggcacc      360

ctggtcacag tgtcctct                                                    378


<210>  309
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  309
caggctgtgg tcacccaaga gcctagcctg tctgtgtctc ctggtggcac agtgacactg       60

acatgtgccc tgtcctctgc ctctgtgtct accagcagct accccagctg gtatcagcag      120

acacctggcc agcctccaag aatgctgatc cacaacacag acaccagatc ctctggggtg      180

ccagacagat tctctggcag catcctgggc aagaaggctg ccctgacaat cactggtgcc      240

caggctgatg atgagtctga ctactactgt gtggtgtacc ttggcaatgg cttctgggtg      300

tttggtggtg gcaccaagct gacagtgctg                                       330


<210>  310
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  310
gaggtgcagc tggtggaaag tggtggtgga ctggttcagc ctggtggcag cctgagactg       60

tcttgtgctg cctctggctt caccttcagc atctacacca tgagctgggt cagacaggct      120

cctggcaaag gcctggaatg ggtgtcagct atcctgtctg atggcagcac ctactatgct      180

gactctgtgg aaggcagatt caccatcagc agagacaaca gcaagaccac actgtacctg      240

cagatgaaca gcctgacagc tgaggacact gctgtgtact actgcaccaa gagagtggaa      300

ggctccttca gaggctgggg acagggaaca ctggtcactg tgtcctct                   348


<210>  311
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  311
gagattgtga tgacacagag ccctggcaca ctgtctctga gccctgggga atctgccaca       60

ctgagctgta gagccagcca gtctgtgtct accacctacc tggcctggta tcagcagaag      120

cctggacagg ctcccagact gctgatctat ggggcctctt ctagagccac aggcatccct      180

gacagatttt ctggcagtgg ctctggcaca gacttcaccc tgaccatcag cagactggaa      240

cctgaggact ttgctgtgta ctactgccag cagtatggtg gcagcaggct gatcacattt      300

ggccagggca caagactgga aatcaag                                          327


<210>  312
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  312
ggcggaggtg gcagcggagg tggcggatca                                        30


<210>  313
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  313
ggtggaggcg gttcaggcgg aggtggcagc ggcggtggag ggtcg                       45


<210>  314
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  314
ggtggaggcg gttcaggcgg aggtggcagc ggcggtggag ggtcaggtgg aggtggatca       60


<210>  315
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  315
ggcggaggag gcggaggtgg aggagga                                           27


<210>  316
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  316
gagcctagag gccccaccat caagccctgt cctccatgca agtgtcctgc tcctaacctg       60

cttggaggcc cctctgtgtt catcttccca cctaagatca aggatgtgct gatgatctct      120

ctgagcccca ttgtgacctg tgtggtggtg gatgtgtctg aggatgaccc tgatgtgcag      180

atctcttggt ttgtgaacaa tgtggaagtg cacacagccc agacacagac ccacagagag      240

gactacaaca gcaccctgag agtggtgtct gccctgccta tccagcacca ggactggatg      300

agtggcaaag agttcaagtg caaagtgaac aacaaggacc tgcctgctcc aattgagaga      360

accatcagca agcccaaggg ctctgttaga gcccctcaag tgtatgtgct gcctccacct      420

gaggaagaga tgaccaagaa acaagtgacc ctgacatgca tggtcacaga cttcatgcct      480

gaggacatct atgtggaatg gaccaacaat ggcaagacag agctgaacta caagaacact      540

gagcctgtgc tggactctga tggcagctac ttcatgtaca gcaagctgag ggttgagaag      600

aagaactggg ttgagagaaa cagctacagc tgctctgtgg tgcatgaggg cctgcacaat      660

caccacacca ccaagagctt cagcagaacc cctggcaag                             699


<210>  317
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  317
gaggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctggggagag cctgaagatc       60

agctgcaaag tgtctggcta tgacttcagc aagtactgga ttggctgggt cagacagatg      120

cctggcaaag gcctggaatg gatgggactg atctaccctg gggactctga caccagatac      180

agccctagcc tggaaggcca ggtgtccatc tctgctgaca agagcatctc tgcagcctac      240

ctgcagttca gcagcctgaa ggcctctgac tctgccatgt actactgtgt cagaaagggc      300

tactctgcct accttggagg atggtttgat ccttggggcc agggcacact ggtcacagtg      360

tcctctggcg gaggtggcag cggaggtggc ggatcagaca tccagctgac acagagccct      420

gacagcctgg ctgcttctct gggagagaga gtgaccatca actgcagaag ctcccagaac      480

atcttctaca acagcaacaa caagaacttc ctggcctggt atcagcagaa ggctggccag      540

tctcctaagc tgctgatcta ctgggccagc accagagaat ctggggtgcc agatagattt      600

tctggcagtg gctctggcac agacttcacc ctgacaatca gtggactgca ggctggggat      660

gttgctgtgt acttctgcca gcagtacttc acagatgccc ctacctttgg tggtggcacc      720

aaggtggaaa tcaagggcgg aggaggcgga ggtggaggag gagagcctag aggccccacc      780

atcaagccct gtcctccatg caagtgtcct gctcctaacc tgcttggagg cccctctgtg      840

ttcatcttcc cacctaagat caaggatgtg ctgatgatct ctctgagccc cattgtgacc      900

tgtgtggtgg tggatgtgtc tgaggatgac cctgatgtgc agatctcttg gtttgtgaac      960

aatgtggaag tgcacacagc ccagacacag acccacagag aggactacaa cagcaccctg     1020

agagtggtgt ctgccctgcc tatccagcac caggactgga tgagtggcaa agagttcaag     1080

tgcaaagtga acaacaagga cctgcctgct ccaattgaga gaaccatcag caagcccaag     1140

ggctctgtta gagcccctca agtgtatgtg ctgcctccac ctgaggaaga gatgaccaag     1200

aaacaagtga ccctgacatg catggtcaca gacttcatgc ctgaggacat ctatgtggaa     1260

tggaccaaca atggcaagac agagctgaac tacaagaaca ctgagcctgt gctggactct     1320

gatggcagct acttcatgta cagcaagctg agggttgaga agaagaactg ggttgagaga     1380

aacagctaca gctgctctgt ggtgcatgag ggcctgcaca atcaccacac caccaagagc     1440

ttcagcagaa cccctggcaa g                                               1461


<210>  318
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  318
gaggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctggggagag cctgaagatc       60

agctgcaaag tgtctggcta tgacttcagc aagtactgga ttggctgggt cagacagatg      120

cctggcaaag gcctggaatg gatgggactg atctaccctg gggactctga caccagatac      180

agccctagcc tggaaggcca ggtgtccatc tctgctgaca agagcatctc tgcagcctac      240

ctgcagttca gcagcctgaa ggcctctgac tctgccatgt actactgtgt cagaaagggc      300

tactctgcct accttggagg atggtttgat ccttggggcc agggcacact ggtcacagtg      360

tcctctggtg gaggcggttc aggcggaggt ggcagcggcg gtggagggtc ggacatccag      420

ctgacacaga gccctgacag cctggctgct tctctgggag agagagtgac catcaactgc      480

agaagctccc agaacatctt ctacaacagc aacaacaaga acttcctggc ctggtatcag      540

cagaaggctg gccagtctcc taagctgctg atctactggg ccagcaccag agaatctggg      600

gtgccagata gattttctgg cagtggctct ggcacagact tcaccctgac aatcagtgga      660

ctgcaggctg gggatgttgc tgtgtacttc tgccagcagt acttcacaga tgcccctacc      720

tttggtggtg gcaccaaggt ggaaatcaag ggcggaggag gcggaggtgg aggaggagag      780

cctagaggcc ccaccatcaa gccctgtcct ccatgcaagt gtcctgctcc taacctgctt      840

ggaggcccct ctgtgttcat cttcccacct aagatcaagg atgtgctgat gatctctctg      900

agccccattg tgacctgtgt ggtggtggat gtgtctgagg atgaccctga tgtgcagatc      960

tcttggtttg tgaacaatgt ggaagtgcac acagcccaga cacagaccca cagagaggac     1020

tacaacagca ccctgagagt ggtgtctgcc ctgcctatcc agcaccagga ctggatgagt     1080

ggcaaagagt tcaagtgcaa agtgaacaac aaggacctgc ctgctccaat tgagagaacc     1140

atcagcaagc ccaagggctc tgttagagcc cctcaagtgt atgtgctgcc tccacctgag     1200

gaagagatga ccaagaaaca agtgaccctg acatgcatgg tcacagactt catgcctgag     1260

gacatctatg tggaatggac caacaatggc aagacagagc tgaactacaa gaacactgag     1320

cctgtgctgg actctgatgg cagctacttc atgtacagca agctgagggt tgagaagaag     1380

aactgggttg agagaaacag ctacagctgc tctgtggtgc atgagggcct gcacaatcac     1440

cacaccacca agagcttcag cagaacccct ggcaag                               1476


<210>  319
<211>  1491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  319
gaggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctggggagag cctgaagatc       60

agctgcaaag tgtctggcta tgacttcagc aagtactgga ttggctgggt cagacagatg      120

cctggcaaag gcctggaatg gatgggactg atctaccctg gggactctga caccagatac      180

agccctagcc tggaaggcca ggtgtccatc tctgctgaca agagcatctc tgcagcctac      240

ctgcagttca gcagcctgaa ggcctctgac tctgccatgt actactgtgt cagaaagggc      300

tactctgcct accttggagg atggtttgat ccttggggcc agggcacact ggtcacagtg      360

tcctctggtg gaggcggttc aggcggaggt ggcagcggcg gtggagggtc aggtggaggt      420

ggatcagaca tccagctgac acagagccct gacagcctgg ctgcttctct gggagagaga      480

gtgaccatca actgcagaag ctcccagaac atcttctaca acagcaacaa caagaacttc      540

ctggcctggt atcagcagaa ggctggccag tctcctaagc tgctgatcta ctgggccagc      600

accagagaat ctggggtgcc agatagattt tctggcagtg gctctggcac agacttcacc      660

ctgacaatca gtggactgca ggctggggat gttgctgtgt acttctgcca gcagtacttc      720

acagatgccc ctacctttgg tggtggcacc aaggtggaaa tcaagggcgg aggaggcgga      780

ggtggaggag gagagcctag aggccccacc atcaagccct gtcctccatg caagtgtcct      840

gctcctaacc tgcttggagg cccctctgtg ttcatcttcc cacctaagat caaggatgtg      900

ctgatgatct ctctgagccc cattgtgacc tgtgtggtgg tggatgtgtc tgaggatgac      960

cctgatgtgc agatctcttg gtttgtgaac aatgtggaag tgcacacagc ccagacacag     1020

acccacagag aggactacaa cagcaccctg agagtggtgt ctgccctgcc tatccagcac     1080

caggactgga tgagtggcaa agagttcaag tgcaaagtga acaacaagga cctgcctgct     1140

ccaattgaga gaaccatcag caagcccaag ggctctgtta gagcccctca agtgtatgtg     1200

ctgcctccac ctgaggaaga gatgaccaag aaacaagtga ccctgacatg catggtcaca     1260

gacttcatgc ctgaggacat ctatgtggaa tggaccaaca atggcaagac agagctgaac     1320

tacaagaaca ctgagcctgt gctggactct gatggcagct acttcatgta cagcaagctg     1380

agggttgaga agaagaactg ggttgagaga aacagctaca gctgctctgt ggtgcatgag     1440

ggcctgcaca atcaccacac caccaagagc ttcagcagaa cccctggcaa g              1491


<210>  320
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  320
gacatccagc tgacacagag ccctgacagc ctggctgctt ctctgggaga gagagtgacc       60

atcaactgca gaagctccca gaacatcttc tacaacagca acaacaagaa cttcctggcc      120

tggtatcagc agaaggctgg ccagtctcct aagctgctga tctactgggc cagcaccaga      180

gaatctgggg tgccagatag attttctggc agtggctctg gcacagactt caccctgaca      240

atcagtggac tgcaggctgg ggatgttgct gtgtacttct gccagcagta cttcacagat      300

gcccctacct ttggtggtgg caccaaggtg gaaatcaagg gcggaggtgg cagcggaggt      360

ggcggatcag aggtgcagct ggtgcagtct ggggctgaag tgaagaagcc tggggagagc      420

ctgaagatca gctgcaaagt gtctggctat gacttcagca agtactggat tggctgggtc      480

agacagatgc ctggcaaagg cctggaatgg atgggactga tctaccctgg ggactctgac      540

accagataca gccctagcct ggaaggccag gtgtccatct ctgctgacaa gagcatctct      600

gcagcctacc tgcagttcag cagcctgaag gcctctgact ctgccatgta ctactgtgtc      660

agaaagggct actctgccta ccttggagga tggtttgatc cttggggcca gggcacactg      720

gtcacagtgt cctctggcgg aggaggcgga ggtggaggag gagagcctag aggccccacc      780

atcaagccct gtcctccatg caagtgtcct gctcctaacc tgcttggagg cccctctgtg      840

ttcatcttcc cacctaagat caaggatgtg ctgatgatct ctctgagccc cattgtgacc      900

tgtgtggtgg tggatgtgtc tgaggatgac cctgatgtgc agatctcttg gtttgtgaac      960

aatgtggaag tgcacacagc ccagacacag acccacagag aggactacaa cagcaccctg     1020

agagtggtgt ctgccctgcc tatccagcac caggactgga tgagtggcaa agagttcaag     1080

tgcaaagtga acaacaagga cctgcctgct ccaattgaga gaaccatcag caagcccaag     1140

ggctctgtta gagcccctca agtgtatgtg ctgcctccac ctgaggaaga gatgaccaag     1200

aaacaagtga ccctgacatg catggtcaca gacttcatgc ctgaggacat ctatgtggaa     1260

tggaccaaca atggcaagac agagctgaac tacaagaaca ctgagcctgt gctggactct     1320

gatggcagct acttcatgta cagcaagctg agggttgaga agaagaactg ggttgagaga     1380

aacagctaca gctgctctgt ggtgcatgag ggcctgcaca atcaccacac caccaagagc     1440

ttcagcagaa cccctggcaa g                                               1461


<210>  321
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  321
gacatccagc tgacacagag ccctgacagc ctggctgctt ctctgggaga gagagtgacc       60

atcaactgca gaagctccca gaacatcttc tacaacagca acaacaagaa cttcctggcc      120

tggtatcagc agaaggctgg ccagtctcct aagctgctga tctactgggc cagcaccaga      180

gaatctgggg tgccagatag attttctggc agtggctctg gcacagactt caccctgaca      240

atcagtggac tgcaggctgg ggatgttgct gtgtacttct gccagcagta cttcacagat      300

gcccctacct ttggtggtgg caccaaggtg gaaatcaagg gtggaggcgg ttcaggcgga      360

ggtggcagcg gcggtggagg gtcggaggtg cagctggtgc agtctggggc tgaagtgaag      420

aagcctgggg agagcctgaa gatcagctgc aaagtgtctg gctatgactt cagcaagtac      480

tggattggct gggtcagaca gatgcctggc aaaggcctgg aatggatggg actgatctac      540

cctggggact ctgacaccag atacagccct agcctggaag gccaggtgtc catctctgct      600

gacaagagca tctctgcagc ctacctgcag ttcagcagcc tgaaggcctc tgactctgcc      660

atgtactact gtgtcagaaa gggctactct gcctaccttg gaggatggtt tgatccttgg      720

ggccagggca cactggtcac agtgtcctct ggcggaggag gcggaggtgg aggaggagag      780

cctagaggcc ccaccatcaa gccctgtcct ccatgcaagt gtcctgctcc taacctgctt      840

ggaggcccct ctgtgttcat cttcccacct aagatcaagg atgtgctgat gatctctctg      900

agccccattg tgacctgtgt ggtggtggat gtgtctgagg atgaccctga tgtgcagatc      960

tcttggtttg tgaacaatgt ggaagtgcac acagcccaga cacagaccca cagagaggac     1020

tacaacagca ccctgagagt ggtgtctgcc ctgcctatcc agcaccagga ctggatgagt     1080

ggcaaagagt tcaagtgcaa agtgaacaac aaggacctgc ctgctccaat tgagagaacc     1140

atcagcaagc ccaagggctc tgttagagcc cctcaagtgt atgtgctgcc tccacctgag     1200

gaagagatga ccaagaaaca agtgaccctg acatgcatgg tcacagactt catgcctgag     1260

gacatctatg tggaatggac caacaatggc aagacagagc tgaactacaa gaacactgag     1320

cctgtgctgg actctgatgg cagctacttc atgtacagca agctgagggt tgagaagaag     1380

aactgggttg agagaaacag ctacagctgc tctgtggtgc atgagggcct gcacaatcac     1440

cacaccacca agagcttcag cagaacccct ggcaag                               1476


<210>  322
<211>  1491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  322
gacatccagc tgacacagag ccctgacagc ctggctgctt ctctgggaga gagagtgacc       60

atcaactgca gaagctccca gaacatcttc tacaacagca acaacaagaa cttcctggcc      120

tggtatcagc agaaggctgg ccagtctcct aagctgctga tctactgggc cagcaccaga      180

gaatctgggg tgccagatag attttctggc agtggctctg gcacagactt caccctgaca      240

atcagtggac tgcaggctgg ggatgttgct gtgtacttct gccagcagta cttcacagat      300

gcccctacct ttggtggtgg caccaaggtg gaaatcaagg gtggaggcgg ttcaggcgga      360

ggtggcagcg gcggtggagg gtcaggtgga ggtggatcag aggtgcagct ggtgcagtct      420

ggggctgaag tgaagaagcc tggggagagc ctgaagatca gctgcaaagt gtctggctat      480

gacttcagca agtactggat tggctgggtc agacagatgc ctggcaaagg cctggaatgg      540

atgggactga tctaccctgg ggactctgac accagataca gccctagcct ggaaggccag      600

gtgtccatct ctgctgacaa gagcatctct gcagcctacc tgcagttcag cagcctgaag      660

gcctctgact ctgccatgta ctactgtgtc agaaagggct actctgccta ccttggagga      720

tggtttgatc cttggggcca gggcacactg gtcacagtgt cctctggcgg aggaggcgga      780

ggtggaggag gagagcctag aggccccacc atcaagccct gtcctccatg caagtgtcct      840

gctcctaacc tgcttggagg cccctctgtg ttcatcttcc cacctaagat caaggatgtg      900

ctgatgatct ctctgagccc cattgtgacc tgtgtggtgg tggatgtgtc tgaggatgac      960

cctgatgtgc agatctcttg gtttgtgaac aatgtggaag tgcacacagc ccagacacag     1020

acccacagag aggactacaa cagcaccctg agagtggtgt ctgccctgcc tatccagcac     1080

caggactgga tgagtggcaa agagttcaag tgcaaagtga acaacaagga cctgcctgct     1140

ccaattgaga gaaccatcag caagcccaag ggctctgtta gagcccctca agtgtatgtg     1200

ctgcctccac ctgaggaaga gatgaccaag aaacaagtga ccctgacatg catggtcaca     1260

gacttcatgc ctgaggacat ctatgtggaa tggaccaaca atggcaagac agagctgaac     1320

tacaagaaca ctgagcctgt gctggactct gatggcagct acttcatgta cagcaagctg     1380

agggttgaga agaagaactg ggttgagaga aacagctaca gctgctctgt ggtgcatgag     1440

ggcctgcaca atcaccacac caccaagagc ttcagcagaa cccctggcaa g              1491


<210>  323
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  323
gaggtgcagc tgctgcagag tggtggtggt gttgtgcagc ctggtggctc tctgagactg       60

tcttgtgaag cctctggctt caccttcagc agctacagca tgcactgggt cagacaggcc      120

cctggcaaag gactggaatg gctgaccctg atcagctaca atggggtcaa caagtactat      180

gccaagtctg tgaagggcag atttgccatc agcagagatg acagcaagtc taccctgttc      240

ctgcagatga acagcctgac cacagatgac actgctgtgt actactgtgc cagatgtccc      300

attcctagag ctgccagcta cagaaatggg gacaactact ttgagtttgg ccagggcacc      360

ctggtcacag tgtcctctgg cggaggtggc agcggaggtg gcggatcaca ggctgtggtc      420

acccaagagc ctagcctgtc tgtgtctcct ggtggcacag tgacactgac atgtgccctg      480

tcctctgcct ctgtgtctac cagcagctac cccagctggt atcagcagac acctggccag      540

cctccaagaa tgctgatcca caacacagac accagatcct ctggggtgcc agacagattc      600

tctggcagca tcctgggcaa gaaggctgcc ctgacaatca ctggtgccca ggctgatgat      660

gagtctgact actactgtgt ggtgtacctt ggcaatggct tctgggtgtt tggtggtggc      720

accaagctga cagtgctggg cggaggaggc ggaggtggag gaggagagcc tagaggcccc      780

accatcaagc cctgtcctcc atgcaagtgt cctgctccta acctgcttgg aggcccctct      840

gtgttcatct tcccacctaa gatcaaggat gtgctgatga tctctctgag ccccattgtg      900

acctgtgtgg tggtggatgt gtctgaggat gaccctgatg tgcagatctc ttggtttgtg      960

aacaatgtgg aagtgcacac agcccagaca cagacccaca gagaggacta caacagcacc     1020

ctgagagtgg tgtctgccct gcctatccag caccaggact ggatgagtgg caaagagttc     1080

aagtgcaaag tgaacaacaa ggacctgcct gctccaattg agagaaccat cagcaagccc     1140

aagggctctg ttagagcccc tcaagtgtat gtgctgcctc cacctgagga agagatgacc     1200

aagaaacaag tgaccctgac atgcatggtc acagacttca tgcctgagga catctatgtg     1260

gaatggacca acaatggcaa gacagagctg aactacaaga acactgagcc tgtgctggac     1320

tctgatggca gctacttcat gtacagcaag ctgagggttg agaagaagaa ctgggttgag     1380

agaaacagct acagctgctc tgtggtgcat gagggcctgc acaatcacca caccaccaag     1440

agcttcagca gaacccctgg caag                                            1464


<210>  324
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  324
gaggtgcagc tgctgcagag tggtggtggt gttgtgcagc ctggtggctc tctgagactg       60

tcttgtgaag cctctggctt caccttcagc agctacagca tgcactgggt cagacaggcc      120

cctggcaaag gactggaatg gctgaccctg atcagctaca atggggtcaa caagtactat      180

gccaagtctg tgaagggcag atttgccatc agcagagatg acagcaagtc taccctgttc      240

ctgcagatga acagcctgac cacagatgac actgctgtgt actactgtgc cagatgtccc      300

attcctagag ctgccagcta cagaaatggg gacaactact ttgagtttgg ccagggcacc      360

ctggtcacag tgtcctctgg tggaggcggt tcaggcggag gtggcagcgg cggtggaggg      420

tcgcaggctg tggtcaccca agagcctagc ctgtctgtgt ctcctggtgg cacagtgaca      480

ctgacatgtg ccctgtcctc tgcctctgtg tctaccagca gctaccccag ctggtatcag      540

cagacacctg gccagcctcc aagaatgctg atccacaaca cagacaccag atcctctggg      600

gtgccagaca gattctctgg cagcatcctg ggcaagaagg ctgccctgac aatcactggt      660

gcccaggctg atgatgagtc tgactactac tgtgtggtgt accttggcaa tggcttctgg      720

gtgtttggtg gtggcaccaa gctgacagtg ctgggcggag gaggcggagg tggaggagga      780

gagcctagag gccccaccat caagccctgt cctccatgca agtgtcctgc tcctaacctg      840

cttggaggcc cctctgtgtt catcttccca cctaagatca aggatgtgct gatgatctct      900

ctgagcccca ttgtgacctg tgtggtggtg gatgtgtctg aggatgaccc tgatgtgcag      960

atctcttggt ttgtgaacaa tgtggaagtg cacacagccc agacacagac ccacagagag     1020

gactacaaca gcaccctgag agtggtgtct gccctgccta tccagcacca ggactggatg     1080

agtggcaaag agttcaagtg caaagtgaac aacaaggacc tgcctgctcc aattgagaga     1140

accatcagca agcccaaggg ctctgttaga gcccctcaag tgtatgtgct gcctccacct     1200

gaggaagaga tgaccaagaa acaagtgacc ctgacatgca tggtcacaga cttcatgcct     1260

gaggacatct atgtggaatg gaccaacaat ggcaagacag agctgaacta caagaacact     1320

gagcctgtgc tggactctga tggcagctac ttcatgtaca gcaagctgag ggttgagaag     1380

aagaactggg ttgagagaaa cagctacagc tgctctgtgg tgcatgaggg cctgcacaat     1440

caccacacca ccaagagctt cagcagaacc cctggcaag                            1479


<210>  325
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  325
gaggtgcagc tgctgcagag tggtggtggt gttgtgcagc ctggtggctc tctgagactg       60

tcttgtgaag cctctggctt caccttcagc agctacagca tgcactgggt cagacaggcc      120

cctggcaaag gactggaatg gctgaccctg atcagctaca atggggtcaa caagtactat      180

gccaagtctg tgaagggcag atttgccatc agcagagatg acagcaagtc taccctgttc      240

ctgcagatga acagcctgac cacagatgac actgctgtgt actactgtgc cagatgtccc      300

attcctagag ctgccagcta cagaaatggg gacaactact ttgagtttgg ccagggcacc      360

ctggtcacag tgtcctctgg tggaggcggt tcaggcggag gtggcagcgg cggtggaggg      420

tcaggtggag gtggatcaca ggctgtggtc acccaagagc ctagcctgtc tgtgtctcct      480

ggtggcacag tgacactgac atgtgccctg tcctctgcct ctgtgtctac cagcagctac      540

cccagctggt atcagcagac acctggccag cctccaagaa tgctgatcca caacacagac      600

accagatcct ctggggtgcc agacagattc tctggcagca tcctgggcaa gaaggctgcc      660

ctgacaatca ctggtgccca ggctgatgat gagtctgact actactgtgt ggtgtacctt      720

ggcaatggct tctgggtgtt tggtggtggc accaagctga cagtgctggg cggaggaggc      780

ggaggtggag gaggagagcc tagaggcccc accatcaagc cctgtcctcc atgcaagtgt      840

cctgctccta acctgcttgg aggcccctct gtgttcatct tcccacctaa gatcaaggat      900

gtgctgatga tctctctgag ccccattgtg acctgtgtgg tggtggatgt gtctgaggat      960

gaccctgatg tgcagatctc ttggtttgtg aacaatgtgg aagtgcacac agcccagaca     1020

cagacccaca gagaggacta caacagcacc ctgagagtgg tgtctgccct gcctatccag     1080

caccaggact ggatgagtgg caaagagttc aagtgcaaag tgaacaacaa ggacctgcct     1140

gctccaattg agagaaccat cagcaagccc aagggctctg ttagagcccc tcaagtgtat     1200

gtgctgcctc cacctgagga agagatgacc aagaaacaag tgaccctgac atgcatggtc     1260

acagacttca tgcctgagga catctatgtg gaatggacca acaatggcaa gacagagctg     1320

aactacaaga acactgagcc tgtgctggac tctgatggca gctacttcat gtacagcaag     1380

ctgagggttg agaagaagaa ctgggttgag agaaacagct acagctgctc tgtggtgcat     1440

gagggcctgc acaatcacca caccaccaag agcttcagca gaacccctgg caag           1494


<210>  326
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  326
caggctgtgg tcacccaaga gcctagcctg tctgtgtctc ctggtggcac agtgacactg       60

acatgtgccc tgtcctctgc ctctgtgtct accagcagct accccagctg gtatcagcag      120

acacctggcc agcctccaag aatgctgatc cacaacacag acaccagatc ctctggggtg      180

ccagacagat tctctggcag catcctgggc aagaaggctg ccctgacaat cactggtgcc      240

caggctgatg atgagtctga ctactactgt gtggtgtacc ttggcaatgg cttctgggtg      300

tttggtggtg gcaccaagct gacagtgctg ggcggaggtg gcagcggagg tggcggatca      360

gaggtgcagc tgctgcagag tggtggtggt gttgtgcagc ctggtggctc tctgagactg      420

tcttgtgaag cctctggctt caccttcagc agctacagca tgcactgggt cagacaggcc      480

cctggcaaag gactggaatg gctgaccctg atcagctaca atggggtcaa caagtactat      540

gccaagtctg tgaagggcag atttgccatc agcagagatg acagcaagtc taccctgttc      600

ctgcagatga acagcctgac cacagatgac actgctgtgt actactgtgc cagatgtccc      660

attcctagag ctgccagcta cagaaatggg gacaactact ttgagtttgg ccagggcacc      720

ctggtcacag tgtcctctgg cggaggaggc ggaggtggag gaggagagcc tagaggcccc      780

accatcaagc cctgtcctcc atgcaagtgt cctgctccta acctgcttgg aggcccctct      840

gtgttcatct tcccacctaa gatcaaggat gtgctgatga tctctctgag ccccattgtg      900

acctgtgtgg tggtggatgt gtctgaggat gaccctgatg tgcagatctc ttggtttgtg      960

aacaatgtgg aagtgcacac agcccagaca cagacccaca gagaggacta caacagcacc     1020

ctgagagtgg tgtctgccct gcctatccag caccaggact ggatgagtgg caaagagttc     1080

aagtgcaaag tgaacaacaa ggacctgcct gctccaattg agagaaccat cagcaagccc     1140

aagggctctg ttagagcccc tcaagtgtat gtgctgcctc cacctgagga agagatgacc     1200

aagaaacaag tgaccctgac atgcatggtc acagacttca tgcctgagga catctatgtg     1260

gaatggacca acaatggcaa gacagagctg aactacaaga acactgagcc tgtgctggac     1320

tctgatggca gctacttcat gtacagcaag ctgagggttg agaagaagaa ctgggttgag     1380

agaaacagct acagctgctc tgtggtgcat gagggcctgc acaatcacca caccaccaag     1440

agcttcagca gaacccctgg caag                                            1464


<210>  327
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  327
caggctgtgg tcacccaaga gcctagcctg tctgtgtctc ctggtggcac agtgacactg       60

acatgtgccc tgtcctctgc ctctgtgtct accagcagct accccagctg gtatcagcag      120

acacctggcc agcctccaag aatgctgatc cacaacacag acaccagatc ctctggggtg      180

ccagacagat tctctggcag catcctgggc aagaaggctg ccctgacaat cactggtgcc      240

caggctgatg atgagtctga ctactactgt gtggtgtacc ttggcaatgg cttctgggtg      300

tttggtggtg gcaccaagct gacagtgctg ggtggaggcg gttcaggcgg aggtggcagc      360

ggcggtggag ggtcggaggt gcagctgctg cagagtggtg gtggtgttgt gcagcctggt      420

ggctctctga gactgtcttg tgaagcctct ggcttcacct tcagcagcta cagcatgcac      480

tgggtcagac aggcccctgg caaaggactg gaatggctga ccctgatcag ctacaatggg      540

gtcaacaagt actatgccaa gtctgtgaag ggcagatttg ccatcagcag agatgacagc      600

aagtctaccc tgttcctgca gatgaacagc ctgaccacag atgacactgc tgtgtactac      660

tgtgccagat gtcccattcc tagagctgcc agctacagaa atggggacaa ctactttgag      720

tttggccagg gcaccctggt cacagtgtcc tctggcggag gaggcggagg tggaggagga      780

gagcctagag gccccaccat caagccctgt cctccatgca agtgtcctgc tcctaacctg      840

cttggaggcc cctctgtgtt catcttccca cctaagatca aggatgtgct gatgatctct      900

ctgagcccca ttgtgacctg tgtggtggtg gatgtgtctg aggatgaccc tgatgtgcag      960

atctcttggt ttgtgaacaa tgtggaagtg cacacagccc agacacagac ccacagagag     1020

gactacaaca gcaccctgag agtggtgtct gccctgccta tccagcacca ggactggatg     1080

agtggcaaag agttcaagtg caaagtgaac aacaaggacc tgcctgctcc aattgagaga     1140

accatcagca agcccaaggg ctctgttaga gcccctcaag tgtatgtgct gcctccacct     1200

gaggaagaga tgaccaagaa acaagtgacc ctgacatgca tggtcacaga cttcatgcct     1260

gaggacatct atgtggaatg gaccaacaat ggcaagacag agctgaacta caagaacact     1320

gagcctgtgc tggactctga tggcagctac ttcatgtaca gcaagctgag ggttgagaag     1380

aagaactggg ttgagagaaa cagctacagc tgctctgtgg tgcatgaggg cctgcacaat     1440

caccacacca ccaagagctt cagcagaacc cctggcaag                            1479


<210>  328
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  328
caggctgtgg tcacccaaga gcctagcctg tctgtgtctc ctggtggcac agtgacactg       60

acatgtgccc tgtcctctgc ctctgtgtct accagcagct accccagctg gtatcagcag      120

acacctggcc agcctccaag aatgctgatc cacaacacag acaccagatc ctctggggtg      180

ccagacagat tctctggcag catcctgggc aagaaggctg ccctgacaat cactggtgcc      240

caggctgatg atgagtctga ctactactgt gtggtgtacc ttggcaatgg cttctgggtg      300

tttggtggtg gcaccaagct gacagtgctg ggtggaggcg gttcaggcgg aggtggcagc      360

ggcggtggag ggtcaggtgg aggtggatca gaggtgcagc tgctgcagag tggtggtggt      420

gttgtgcagc ctggtggctc tctgagactg tcttgtgaag cctctggctt caccttcagc      480

agctacagca tgcactgggt cagacaggcc cctggcaaag gactggaatg gctgaccctg      540

atcagctaca atggggtcaa caagtactat gccaagtctg tgaagggcag atttgccatc      600

agcagagatg acagcaagtc taccctgttc ctgcagatga acagcctgac cacagatgac      660

actgctgtgt actactgtgc cagatgtccc attcctagag ctgccagcta cagaaatggg      720

gacaactact ttgagtttgg ccagggcacc ctggtcacag tgtcctctgg cggaggaggc      780

ggaggtggag gaggagagcc tagaggcccc accatcaagc cctgtcctcc atgcaagtgt      840

cctgctccta acctgcttgg aggcccctct gtgttcatct tcccacctaa gatcaaggat      900

gtgctgatga tctctctgag ccccattgtg acctgtgtgg tggtggatgt gtctgaggat      960

gaccctgatg tgcagatctc ttggtttgtg aacaatgtgg aagtgcacac agcccagaca     1020

cagacccaca gagaggacta caacagcacc ctgagagtgg tgtctgccct gcctatccag     1080

caccaggact ggatgagtgg caaagagttc aagtgcaaag tgaacaacaa ggacctgcct     1140

gctccaattg agagaaccat cagcaagccc aagggctctg ttagagcccc tcaagtgtat     1200

gtgctgcctc cacctgagga agagatgacc aagaaacaag tgaccctgac atgcatggtc     1260

acagacttca tgcctgagga catctatgtg gaatggacca acaatggcaa gacagagctg     1320

aactacaaga acactgagcc tgtgctggac tctgatggca gctacttcat gtacagcaag     1380

ctgagggttg agaagaagaa ctgggttgag agaaacagct acagctgctc tgtggtgcat     1440

gagggcctgc acaatcacca caccaccaag agcttcagca gaacccctgg caag           1494


<210>  329
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  329
gaggtgcagc tggtggaaag tggtggtgga ctggttcagc ctggtggcag cctgagactg       60

tcttgtgctg cctctggctt caccttcagc atctacacca tgagctgggt cagacaggct      120

cctggcaaag gcctggaatg ggtgtcagct atcctgtctg atggcagcac ctactatgct      180

gactctgtgg aaggcagatt caccatcagc agagacaaca gcaagaccac actgtacctg      240

cagatgaaca gcctgacagc tgaggacact gctgtgtact actgcaccaa gagagtggaa      300

ggctccttca gaggctgggg acagggaaca ctggtcactg tgtcctctgg cggaggtggc      360

agcggaggtg gcggatcaga gattgtgatg acacagagcc ctggcacact gtctctgagc      420

cctggggaat ctgccacact gagctgtaga gccagccagt ctgtgtctac cacctacctg      480

gcctggtatc agcagaagcc tggacaggct cccagactgc tgatctatgg ggcctcttct      540

agagccacag gcatccctga cagattttct ggcagtggct ctggcacaga cttcaccctg      600

accatcagca gactggaacc tgaggacttt gctgtgtact actgccagca gtatggtggc      660

agcaggctga tcacatttgg ccagggcaca agactggaaa tcaagggcgg aggaggcgga      720

ggtggaggag gagagcctag aggccccacc atcaagccct gtcctccatg caagtgtcct      780

gctcctaacc tgcttggagg cccctctgtg ttcatcttcc cacctaagat caaggatgtg      840

ctgatgatct ctctgagccc cattgtgacc tgtgtggtgg tggatgtgtc tgaggatgac      900

cctgatgtgc agatctcttg gtttgtgaac aatgtggaag tgcacacagc ccagacacag      960

acccacagag aggactacaa cagcaccctg agagtggtgt ctgccctgcc tatccagcac     1020

caggactgga tgagtggcaa agagttcaag tgcaaagtga acaacaagga cctgcctgct     1080

ccaattgaga gaaccatcag caagcccaag ggctctgtta gagcccctca agtgtatgtg     1140

ctgcctccac ctgaggaaga gatgaccaag aaacaagtga ccctgacatg catggtcaca     1200

gacttcatgc ctgaggacat ctatgtggaa tggaccaaca atggcaagac agagctgaac     1260

tacaagaaca ctgagcctgt gctggactct gatggcagct acttcatgta cagcaagctg     1320

agggttgaga agaagaactg ggttgagaga aacagctaca gctgctctgt ggtgcatgag     1380

ggcctgcaca atcaccacac caccaagagc ttcagcagaa cccctggcaa g              1431


<210>  330
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  330
gaggtgcagc tggtggaaag tggtggtgga ctggttcagc ctggtggcag cctgagactg       60

tcttgtgctg cctctggctt caccttcagc atctacacca tgagctgggt cagacaggct      120

cctggcaaag gcctggaatg ggtgtcagct atcctgtctg atggcagcac ctactatgct      180

gactctgtgg aaggcagatt caccatcagc agagacaaca gcaagaccac actgtacctg      240

cagatgaaca gcctgacagc tgaggacact gctgtgtact actgcaccaa gagagtggaa      300

ggctccttca gaggctgggg acagggaaca ctggtcactg tgtcctctgg tggaggcggt      360

tcaggcggag gtggcagcgg cggtggaggg tcggagattg tgatgacaca gagccctggc      420

acactgtctc tgagccctgg ggaatctgcc acactgagct gtagagccag ccagtctgtg      480

tctaccacct acctggcctg gtatcagcag aagcctggac aggctcccag actgctgatc      540

tatggggcct cttctagagc cacaggcatc cctgacagat tttctggcag tggctctggc      600

acagacttca ccctgaccat cagcagactg gaacctgagg actttgctgt gtactactgc      660

cagcagtatg gtggcagcag gctgatcaca tttggccagg gcacaagact ggaaatcaag      720

ggcggaggag gcggaggtgg aggaggagag cccaggggcc ccaccatcaa gccctgcccc      780

ccctgtaagt gtccagctcc caacctgctg ggcggaccca gcgtgttcat cttccccccc      840

aagatcaagg acgtgctgat gatcagcctg agccccatcg tgacctgcgt ggtggtggac      900

gtgagcgagg acgaccccga cgtgcagatc agctggttcg tgaacaacgt ggaggtgcac      960

accgcccaga cccagaccca cagagaggac tacaactcta ctctgagggt cgtgtccgcc     1020

ctgcccatcc agcaccagga ctggatgagc ggcaaagagt tcaagtgcaa ggtcaacaac     1080

aaggacctgc cagcccccat cgagaggacc atcagcaagc ccaagggcag cgtgagagcc     1140

ccacaggtct acgtgctgcc cccacccgag gaagagatga ccaagaagca ggtcacactg     1200

acctgcatgg tgaccgactt catgcccgag gacatctacg tggagtggac caacaacggc     1260

aagaccgagc tgaactacaa gaacaccgag ccagtgctgg acagcgacgg cagctacttc     1320

atgtacagca agctgagggt ggagaagaag aactgggtcg agaggaacag ctacagctgc     1380

agcgtggtgc acgagggcct gcacaaccac cacaccacca agagcttcag caggaccccc     1440

ggcaag                                                                1446


<210>  331
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  331
gaggtgcagc tggtggaaag tggtggtgga ctggttcagc ctggtggcag cctgagactg       60

tcttgtgctg cctctggctt caccttcagc atctacacca tgagctgggt cagacaggct      120

cctggcaaag gcctggaatg ggtgtcagct atcctgtctg atggcagcac ctactatgct      180

gactctgtgg aaggcagatt caccatcagc agagacaaca gcaagaccac actgtacctg      240

cagatgaaca gcctgacagc tgaggacact gctgtgtact actgcaccaa gagagtggaa      300

ggctccttca gaggctgggg acagggaaca ctggtcactg tgtcctctgg tggaggcggt      360

tcaggcggag gtggcagcgg cggtggaggg tcaggtggag gtggatcaga gattgtgatg      420

acacagagcc ctggcacact gtctctgagc cctggggaat ctgccacact gagctgtaga      480

gccagccagt ctgtgtctac cacctacctg gcctggtatc agcagaagcc tggacaggct      540

cccagactgc tgatctatgg ggcctcttct agagccacag gcatccctga cagattttct      600

ggcagtggct ctggcacaga cttcaccctg accatcagca gactggaacc tgaggacttt      660

gctgtgtact actgccagca gtatggtggc agcaggctga tcacatttgg ccagggcaca      720

agactggaaa tcaagggcgg aggaggcgga ggtggaggag gagagcctag aggccccacc      780

atcaagccct gtcctccatg caagtgtcct gctcctaacc tgcttggagg cccctctgtg      840

ttcatcttcc cacctaagat caaggatgtg ctgatgatct ctctgagccc cattgtgacc      900

tgtgtggtgg tggatgtgtc tgaggatgac cctgatgtgc agatctcttg gtttgtgaac      960

aatgtggaag tgcacacagc ccagacacag acccacagag aggactacaa cagcaccctg     1020

agagtggtgt ctgccctgcc tatccagcac caggactgga tgagtggcaa agagttcaag     1080

tgcaaagtga acaacaagga cctgcctgct ccaattgaga gaaccatcag caagcccaag     1140

ggctctgtta gagcccctca agtgtatgtg ctgcctccac ctgaggaaga gatgaccaag     1200

aaacaagtga ccctgacatg catggtcaca gacttcatgc ctgaggacat ctatgtggaa     1260

tggaccaaca atggcaagac agagctgaac tacaagaaca ctgagcctgt gctggactct     1320

gatggcagct acttcatgta cagcaagctg agggttgaga agaagaactg ggttgagaga     1380

aacagctaca gctgctctgt ggtgcatgag ggcctgcaca atcaccacac caccaagagc     1440

ttcagcagaa cccctggcaa g                                               1461


<210>  332
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  332
gagattgtga tgacacagag ccctggcaca ctgtctctga gccctgggga atctgccaca       60

ctgagctgta gagccagcca gtctgtgtct accacctacc tggcctggta tcagcagaag      120

cctggacagg ctcccagact gctgatctat ggggcctctt ctagagccac aggcatccct      180

gacagatttt ctggcagtgg ctctggcaca gacttcaccc tgaccatcag cagactggaa      240

cctgaggact ttgctgtgta ctactgccag cagtatggtg gcagcaggct gatcacattt      300

ggccagggca caagactgga aatcaagggc ggaggtggca gcggaggtgg cggatcagag      360

gtgcagctgg tggaaagtgg tggtggactg gttcagcctg gtggcagcct gagactgtct      420

tgtgctgcct ctggcttcac cttcagcatc tacaccatga gctgggtcag acaggctcct      480

ggcaaaggcc tggaatgggt gtcagctatc ctgtctgatg gcagcaccta ctatgctgac      540

tctgtggaag gcagattcac catcagcaga gacaacagca agaccacact gtacctgcag      600

atgaacagcc tgacagctga ggacactgct gtgtactact gcaccaagag agtggaaggc      660

tccttcagag gctggggaca gggaacactg gtcactgtgt cctctggcgg aggaggcgga      720

ggtggaggag gagagcctag aggccccacc atcaagccct gtcctccatg caagtgtcct      780

gctcctaacc tgcttggagg cccctctgtg ttcatcttcc cacctaagat caaggatgtg      840

ctgatgatct ctctgagccc cattgtgacc tgtgtggtgg tggatgtgtc tgaggatgac      900

cctgatgtgc agatctcttg gtttgtgaac aatgtggaag tgcacacagc ccagacacag      960

acccacagag aggactacaa cagcaccctg agagtggtgt ctgccctgcc tatccagcac     1020

caggactgga tgagtggcaa agagttcaag tgcaaagtga acaacaagga cctgcctgct     1080

ccaattgaga gaaccatcag caagcccaag ggctctgtta gagcccctca agtgtatgtg     1140

ctgcctccac ctgaggaaga gatgaccaag aaacaagtga ccctgacatg catggtcaca     1200

gacttcatgc ctgaggacat ctatgtggaa tggaccaaca atggcaagac agagctgaac     1260

tacaagaaca ctgagcctgt gctggactct gatggcagct acttcatgta cagcaagctg     1320

agggttgaga agaagaactg ggttgagaga aacagctaca gctgctctgt ggtgcatgag     1380

ggcctgcaca atcaccacac caccaagagc ttcagcagaa cccctggcaa g              1431


<210>  333
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  333
gagattgtga tgacacagag ccctggcaca ctgtctctga gccctgggga atctgccaca       60

ctgagctgta gagccagcca gtctgtgtct accacctacc tggcctggta tcagcagaag      120

cctggacagg ctcccagact gctgatctat ggggcctctt ctagagccac aggcatccct      180

gacagatttt ctggcagtgg ctctggcaca gacttcaccc tgaccatcag cagactggaa      240

cctgaggact ttgctgtgta ctactgccag cagtatggtg gcagcaggct gatcacattt      300

ggccagggca caagactgga aatcaagggt ggaggcggtt caggcggagg tggcagcggc      360

ggtggagggt cggaggtgca gctggtggaa agtggtggtg gactggttca gcctggtggc      420

agcctgagac tgtcttgtgc tgcctctggc ttcaccttca gcatctacac catgagctgg      480

gtcagacagg ctcctggcaa aggcctggaa tgggtgtcag ctatcctgtc tgatggcagc      540

acctactatg ctgactctgt ggaaggcaga ttcaccatca gcagagacaa cagcaagacc      600

acactgtacc tgcagatgaa cagcctgaca gctgaggaca ctgctgtgta ctactgcacc      660

aagagagtgg aaggctcctt cagaggctgg ggacagggaa cactggtcac tgtgtcctct      720

ggcggaggag gcggaggtgg aggaggagag cctagaggcc ccaccatcaa gccctgtcct      780

ccatgcaagt gtcctgctcc taacctgctt ggaggcccct ctgtgttcat cttcccacct      840

aagatcaagg atgtgctgat gatctctctg agccccattg tgacctgtgt ggtggtggat      900

gtgtctgagg atgaccctga tgtgcagatc tcttggtttg tgaacaatgt ggaagtgcac      960

acagcccaga cacagaccca cagagaggac tacaacagca ccctgagagt ggtgtctgcc     1020

ctgcctatcc agcaccagga ctggatgagt ggcaaagagt tcaagtgcaa agtgaacaac     1080

aaggacctgc ctgctccaat tgagagaacc atcagcaagc ccaagggctc tgttagagcc     1140

cctcaagtgt atgtgctgcc tccacctgag gaagagatga ccaagaaaca agtgaccctg     1200

acatgcatgg tcacagactt catgcctgag gacatctatg tggaatggac caacaatggc     1260

aagacagagc tgaactacaa gaacactgag cctgtgctgg actctgatgg cagctacttc     1320

atgtacagca agctgagggt tgagaagaag aactgggttg agagaaacag ctacagctgc     1380

tctgtggtgc atgagggcct gcacaatcac cacaccacca agagcttcag cagaacccct     1440

ggcaag                                                                1446


<210>  334
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  334
gagattgtga tgacacagag ccctggcaca ctgtctctga gccctgggga atctgccaca       60

ctgagctgta gagccagcca gtctgtgtct accacctacc tggcctggta tcagcagaag      120

cctggacagg ctcccagact gctgatctat ggggcctctt ctagagccac aggcatccct      180

gacagatttt ctggcagtgg ctctggcaca gacttcaccc tgaccatcag cagactggaa      240

cctgaggact ttgctgtgta ctactgccag cagtatggtg gcagcaggct gatcacattt      300

ggccagggca caagactgga aatcaagggt ggaggcggtt caggcggagg tggcagcggc      360

ggtggagggt caggtggagg tggatcagag gtgcagctgg tggaaagtgg tggtggactg      420

gttcagcctg gtggcagcct gagactgtct tgtgctgcct ctggcttcac cttcagcatc      480

tacaccatga gctgggtcag acaggctcct ggcaaaggcc tggaatgggt gtcagctatc      540

ctgtctgatg gcagcaccta ctatgctgac tctgtggaag gcagattcac catcagcaga      600

gacaacagca agaccacact gtacctgcag atgaacagcc tgacagctga ggacactgct      660

gtgtactact gcaccaagag agtggaaggc tccttcagag gctggggaca gggaacactg      720

gtcactgtgt cctctggcgg aggaggcgga ggtggaggag gagagcctag aggccccacc      780

atcaagccct gtcctccatg caagtgtcct gctcctaacc tgcttggagg cccctctgtg      840

ttcatcttcc cacctaagat caaggatgtg ctgatgatct ctctgagccc cattgtgacc      900

tgtgtggtgg tggatgtgtc tgaggatgac cctgatgtgc agatctcttg gtttgtgaac      960

aatgtggaag tgcacacagc ccagacacag acccacagag aggactacaa cagcaccctg     1020

agagtggtgt ctgccctgcc tatccagcac caggactgga tgagtggcaa agagttcaag     1080

tgcaaagtga acaacaagga cctgcctgct ccaattgaga gaaccatcag caagcccaag     1140

ggctctgtta gagcccctca agtgtatgtg ctgcctccac ctgaggaaga gatgaccaag     1200

aaacaagtga ccctgacatg catggtcaca gacttcatgc ctgaggacat ctatgtggaa     1260

tggaccaaca atggcaagac agagctgaac tacaagaaca ctgagcctgt gctggactct     1320

gatggcagct acttcatgta cagcaagctg agggttgaga agaagaactg ggttgagaga     1380

aacagctaca gctgctctgt ggtgcatgag ggcctgcaca atcaccacac caccaagagc     1440

ttcagcagaa cccctggcaa g                                               1461


<210>  335
<211>  1488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  335
caggtccagc tgcaagagtc tggccctgga ctggtcaagc cttctggcac actgagcctg       60

acctgtgctg tgactggtgg cagcatcagc agcagcaatt ggtggtcttg ggtcagacag      120

agccctggca aaggcctgga atggattgga gagatccacc atgatggcaa cctgaactac      180

aaccctctgc tgaagtccag agtgtccatg agcctggaca gaagcaagaa ccagttcagc      240

ctgaagctga cctctgtgac agctgctgac actgctgtgt actactgtgc cagatgggac      300

ttcttctttg actcctccta ctacatcagg ggctttgacc tgtggggcca gggcacaatg      360

gttacagtgt cctctggtgg aggcggttca ggcggaggtg gcagcggcgg tggagggtca      420

ggtggaggtg gatcagagac aaccctgaca cagagccctg gcacattgtc tctgagccct      480

ggggagagag tgaccctgtc ttgtagagcc agccagtctg tggacagaaa ctacctggcc      540

tggtatcagc agaagcctgg ccagtctcct agactgctga tctactctgc ctctaggaga      600

gccacaggca tccctgacag attttctggc agtggctctg gcacagactt caccctgacc      660

atcagcagac tggaacctga ggactttgtg gtgtactact gccagcagta tggtggcagc      720

cctcctatca catttggcca gggcacaaga ctggaaatca agggcggagg aggcggaggt      780

ggaggaggag agcctagagg ccccaccatc aagccctgtc ctccatgcaa gtgtcctgct      840

cctaacctgc ttggaggccc ctctgtgttc atcttcccac ctaagatcaa ggatgtgctg      900

atgatctctc tgagccccat tgtgacctgt gtggtggtgg atgtgtctga ggatgaccct      960

gatgtgcaga tctcttggtt tgtgaacaat gtggaagtgc acacagccca gacacagacc     1020

cacagagagg actacaacag caccctgaga gtggtgtctg ccctgcctat ccagcaccag     1080

gactggatga gtggcaaaga gttcaagtgc aaagtgaaca acaaggacct gcctgctcca     1140

attgagagaa ccatcagcaa gcccaagggc tctgttagag cccctcaagt gtatgtgctg     1200

cctccacctg aggaagagat gaccaagaaa caagtgaccc tgacatgcat ggtcacagac     1260

ttcatgcctg aggacatcta tgtggaatgg accaacaatg gcaagacaga gctgaactac     1320

aagaacactg agcctgtgct ggactctgat ggcagctact tcatgtacag caagctgagg     1380

gttgagaaga agaactgggt tgagagaaac agctacagct gctctgtggt gcatgagggc     1440

ctgcacaatc accacaccac caagagcttc agcagaaccc ctggcaag                  1488


<210>  336
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  336
caggtccagc tgcaagagtc tggccctgga ctggtcaagc cttctggcac actgagcctg       60

acctgtgctg tgactggtgg cagcatcagc agcagcaatt ggtggtcttg ggtcagacag      120

agccctggca aaggcctgga atggattgga gagatccacc atgatggcaa cctgaactac      180

aaccctctgc tgaagtccag agtgtccatg agcctggaca gaagcaagaa ccagttcagc      240

ctgaagctga cctctgtgac agctgctgac actgctgtgt actactgtgc cagatgggac      300

ttcttctttg actcctccta ctacatcagg ggctttgacc tgtggggcca gggcacaatg      360

gttacagtgt cctctggtgg aggcggttca ggcggaggtg gcagcggcgg tggagggtcg      420

gagacaaccc tgacacagag ccctggcaca ttgtctctga gccctgggga gagagtgacc      480

ctgtcttgta gagccagcca gtctgtggac agaaactacc tggcctggta tcagcagaag      540

cctggccagt ctcctagact gctgatctac tctgcctcta ggagagccac aggcatccct      600

gacagatttt ctggcagtgg ctctggcaca gacttcaccc tgaccatcag cagactggaa      660

cctgaggact ttgtggtgta ctactgccag cagtatggtg gcagccctcc tatcacattt      720

ggccagggca caagactgga aatcaagggc ggaggaggcg gaggtggagg aggagagcct      780

agaggcccca ccatcaagcc ctgtcctcca tgcaagtgtc ctgctcctaa cctgcttgga      840

ggcccctctg tgttcatctt cccacctaag atcaaggatg tgctgatgat ctctctgagc      900

cccattgtga cctgtgtggt ggtggatgtg tctgaggatg accctgatgt gcagatctct      960

tggtttgtga acaatgtgga agtgcacaca gcccagacac agacccacag agaggactac     1020

aacagcaccc tgagagtggt gtctgccctg cctatccagc accaggactg gatgagtggc     1080

aaagagttca agtgcaaagt gaacaacaag gacctgcctg ctccaattga gagaaccatc     1140

agcaagccca agggctctgt tagagcccct caagtgtatg tgctgcctcc acctgaggaa     1200

gagatgacca agaaacaagt gaccctgaca tgcatggtca cagacttcat gcctgaggac     1260

atctatgtgg aatggaccaa caatggcaag acagagctga actacaagaa cactgagcct     1320

gtgctggact ctgatggcag ctacttcatg tacagcaagc tgagggttga gaagaagaac     1380

tgggttgaga gaaacagcta cagctgctct gtggtgcatg agggcctgca caatcaccac     1440

accaccaaga gcttcagcag aacccctggc aag                                  1473


<210>  337
<211>  1458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  337
caggtccagc tgcaagagtc tggccctgga ctggtcaagc cttctggcac actgagcctg       60

acctgtgctg tgactggtgg cagcatcagc agcagcaatt ggtggtcttg ggtcagacag      120

agccctggca aaggcctgga atggattgga gagatccacc atgatggcaa cctgaactac      180

aaccctctgc tgaagtccag agtgtccatg agcctggaca gaagcaagaa ccagttcagc      240

ctgaagctga cctctgtgac agctgctgac actgctgtgt actactgtgc cagatgggac      300

ttcttctttg actcctccta ctacatcagg ggctttgacc tgtggggcca gggcacaatg      360

gttacagtgt cctctggcgg aggtggcagc ggaggtggcg gatcagagac aaccctgaca      420

cagagccctg gcacattgtc tctgagccct ggggagagag tgaccctgtc ttgtagagcc      480

agccagtctg tggacagaaa ctacctggcc tggtatcagc agaagcctgg ccagtctcct      540

agactgctga tctactctgc ctctaggaga gccacaggca tccctgacag attttctggc      600

agtggctctg gcacagactt caccctgacc atcagcagac tggaacctga ggactttgtg      660

gtgtactact gccagcagta tggtggcagc cctcctatca catttggcca gggcacaaga      720

ctggaaatca agggcggagg aggcggaggt ggaggaggag agcctagagg ccccaccatc      780

aagccctgtc ctccatgcaa gtgtcctgct cctaacctgc ttggaggccc ctctgtgttc      840

atcttcccac ctaagatcaa ggatgtgctg atgatctctc tgagccccat tgtgacctgt      900

gtggtggtgg atgtgtctga ggatgaccct gatgtgcaga tctcttggtt tgtgaacaat      960

gtggaagtgc acacagccca gacacagacc cacagagagg actacaacag caccctgaga     1020

gtggtgtctg ccctgcctat ccagcaccag gactggatga gtggcaaaga gttcaagtgc     1080

aaagtgaaca acaaggacct gcctgctcca attgagagaa ccatcagcaa gcccaagggc     1140

tctgttagag cccctcaagt gtatgtgctg cctccacctg aggaagagat gaccaagaaa     1200

caagtgaccc tgacatgcat ggtcacagac ttcatgcctg aggacatcta tgtggaatgg     1260

accaacaatg gcaagacaga gctgaactac aagaacactg agcctgtgct ggactctgat     1320

ggcagctact tcatgtacag caagctgagg gttgagaaga agaactgggt tgagagaaac     1380

agctacagct gctctgtggt gcatgagggc ctgcacaatc accacaccac caagagcttc     1440

agcagaaccc ctggcaag                                                   1458


<210>  338
<211>  1488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  338
gagacaaccc tgacacagag ccctggcaca ttgtctctga gccctgggga gagagtgacc       60

ctgtcttgta gagccagcca gtctgtggac agaaactacc tggcctggta tcagcagaag      120

cctggccagt ctcctagact gctgatctac tctgcctcta ggagagccac aggcatccct      180

gacagatttt ctggcagtgg ctctggcaca gacttcaccc tgaccatcag cagactggaa      240

cctgaggact ttgtggtgta ctactgccag cagtatggtg gcagccctcc tatcacattt      300

ggccagggca caagactgga aatcaagggt ggaggcggtt caggcggagg tggcagcggc      360

ggtggagggt caggtggagg tggatcacag gtccagctgc aagagtctgg ccctggactg      420

gtcaagcctt ctggcacact gagcctgacc tgtgctgtga ctggtggcag catcagcagc      480

agcaattggt ggtcttgggt cagacagagc cctggcaaag gcctggaatg gattggagag      540

atccaccatg atggcaacct gaactacaac cctctgctga agtccagagt gtccatgagc      600

ctggacagaa gcaagaacca gttcagcctg aagctgacct ctgtgacagc tgctgacact      660

gctgtgtact actgtgccag atgggacttc ttctttgact cctcctacta catcaggggc      720

tttgacctgt ggggccaggg cacaatggtt acagtgtcct ctggcggagg aggcggaggt      780

ggaggaggag agcctagagg ccccaccatc aagccctgtc ctccatgcaa gtgtcctgct      840

cctaacctgc ttggaggccc ctctgtgttc atcttcccac ctaagatcaa ggatgtgctg      900

atgatctctc tgagccccat tgtgacctgt gtggtggtgg atgtgtctga ggatgaccct      960

gatgtgcaga tctcttggtt tgtgaacaat gtggaagtgc acacagccca gacacagacc     1020

cacagagagg actacaacag caccctgaga gtggtgtctg ccctgcctat ccagcaccag     1080

gactggatga gtggcaaaga gttcaagtgc aaagtgaaca acaaggacct gcctgctcca     1140

attgagagaa ccatcagcaa gcccaagggc tctgttagag cccctcaagt gtatgtgctg     1200

cctccacctg aggaagagat gaccaagaaa caagtgaccc tgacatgcat ggtcacagac     1260

ttcatgcctg aggacatcta tgtggaatgg accaacaatg gcaagacaga gctgaactac     1320

aagaacactg agcctgtgct ggactctgat ggcagctact tcatgtacag caagctgagg     1380

gttgagaaga agaactgggt tgagagaaac agctacagct gctctgtggt gcatgagggc     1440

ctgcacaatc accacaccac caagagcttc agcagaaccc ctggcaag                  1488


<210>  339
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  339
gagacaaccc tgacacagag ccctggcaca ttgtctctga gccctgggga gagagtgacc       60

ctgtcttgta gagccagcca gtctgtggac agaaactacc tggcctggta tcagcagaag      120

cctggccagt ctcctagact gctgatctac tctgcctcta ggagagccac aggcatccct      180

gacagatttt ctggcagtgg ctctggcaca gacttcaccc tgaccatcag cagactggaa      240

cctgaggact ttgtggtgta ctactgccag cagtatggtg gcagccctcc tatcacattt      300

ggccagggca caagactgga aatcaagggt ggaggcggtt caggcggagg tggcagcggc      360

ggtggagggt cgcaggtcca gctgcaagag tctggccctg gactggtcaa gccttctggc      420

acactgagcc tgacctgtgc tgtgactggt ggcagcatca gcagcagcaa ttggtggtct      480

tgggtcagac agagccctgg caaaggcctg gaatggattg gagagatcca ccatgatggc      540

aacctgaact acaaccctct gctgaagtcc agagtgtcca tgagcctgga cagaagcaag      600

aaccagttca gcctgaagct gacctctgtg acagctgctg acactgctgt gtactactgt      660

gccagatggg acttcttctt tgactcctcc tactacatca ggggctttga cctgtggggc      720

cagggcacaa tggttacagt gtcctctggc ggaggaggcg gaggtggagg aggagagcct      780

agaggcccca ccatcaagcc ctgtcctcca tgcaagtgtc ctgctcctaa cctgcttgga      840

ggcccctctg tgttcatctt cccacctaag atcaaggatg tgctgatgat ctctctgagc      900

cccattgtga cctgtgtggt ggtggatgtg tctgaggatg accctgatgt gcagatctct      960

tggtttgtga acaatgtgga agtgcacaca gcccagacac agacccacag agaggactac     1020

aacagcaccc tgagagtggt gtctgccctg cctatccagc accaggactg gatgagtggc     1080

aaagagttca agtgcaaagt gaacaacaag gacctgcctg ctccaattga gagaaccatc     1140

agcaagccca agggctctgt tagagcccct caagtgtatg tgctgcctcc acctgaggaa     1200

gagatgacca agaaacaagt gaccctgaca tgcatggtca cagacttcat gcctgaggac     1260

atctatgtgg aatggaccaa caatggcaag acagagctga actacaagaa cactgagcct     1320

gtgctggact ctgatggcag ctacttcatg tacagcaagc tgagggttga gaagaagaac     1380

tgggttgaga gaaacagcta cagctgctct gtggtgcatg agggcctgca caatcaccac     1440

accaccaaga gcttcagcag aacccctggc aag                                  1473


<210>  340
<211>  1457
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  340
agacaaccct gacacagagc cctggcacat tgtctctgag ccctggggag agagtgaccc       60

tgtcttgtag agccagccag tctgtggaca gaaactacct ggcctggtat cagcagaagc      120

ctggccagtc tcctagactg ctgatctact ctgcctctag gagagccaca ggcatccctg      180

acagattttc tggcagtggc tctggcacag acttcaccct gaccatcagc agactggaac      240

ctgaggactt tgtggtgtac tactgccagc agtatggtgg cagccctcct atcacatttg      300

gccagggcac aagactggaa atcaagggcg gaggtggcag cggaggtggc ggatcacagg      360

tccagctgca agagtctggc cctggactgg tcaagccttc tggcacactg agcctgacct      420

gtgctgtgac tggtggcagc atcagcagca gcaattggtg gtcttgggtc agacagagcc      480

ctggcaaagg cctggaatgg attggagaga tccaccatga tggcaacctg aactacaacc      540

ctctgctgaa gtccagagtg tccatgagcc tggacagaag caagaaccag ttcagcctga      600

agctgacctc tgtgacagct gctgacactg ctgtgtacta ctgtgccaga tgggacttct      660

tctttgactc ctcctactac atcaggggct ttgacctgtg gggccagggc acaatggtta      720

cagtgtcctc tggcggagga ggcggaggtg gaggaggaga gcctagaggc cccaccatca      780

agccctgtcc tccatgcaag tgtcctgctc ctaacctgct tggaggcccc tctgtgttca      840

tcttcccacc taagatcaag gatgtgctga tgatctctct gagccccatt gtgacctgtg      900

tggtggtgga tgtgtctgag gatgaccctg atgtgcagat ctcttggttt gtgaacaatg      960

tggaagtgca cacagcccag acacagaccc acagagagga ctacaacagc accctgagag     1020

tggtgtctgc cctgcctatc cagcaccagg actggatgag tggcaaagag ttcaagtgca     1080

aagtgaacaa caaggacctg cctgctccaa ttgagagaac catcagcaag cccaagggct     1140

ctgttagagc ccctcaagtg tatgtgctgc ctccacctga ggaagagatg accaagaaac     1200

aagtgaccct gacatgcatg gtcacagact tcatgcctga ggacatctat gtggaatgga     1260

ccaacaatgg caagacagag ctgaactaca agaacactga gcctgtgctg gactctgatg     1320

gcagctactt catgtacagc aagctgaggg ttgagaagaa gaactgggtt gagagaaaca     1380

gctacagctg ctctgtggtg catgagggcc tgcacaatca ccacaccacc aagagcttca     1440

gcagaacccc tggcaag                                                    1457


<210>  341
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; kozak sequence

<400>  341
gccacc                                                                   6


<210>  342
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV capsid protein

<400>  342

Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr 
1               5                   10                  15      


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            20                  25                  30      


<210>  343
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  343
ttacccgggg agcatgtcaa ggtcaaaatc gtcaagagcg tcagcaggca gcatatcaag       60

gtcaaagtcg tcaagggcat cggctgggag catgtctaag tcaaaatcgt caagggcgtc      120

ggtcggcccg ccgctttcgc actttagctg tttctccagg ccacatatga ttagttccag      180

gccgaaaagg aaggcaggtt cggctccctg ccggtcgaac agctcaattg cttgtttcag      240

aagtgggggc atagaatcgg tggtaggtgt ctctctttcc tcttttgcta cttgatgctc      300

ctgttcctcc aatacgcagc ccagtgtaaa gtggcccacg gcggacagag cgtacagtgc      360

gttctccagg gagaagcctt gctgacacag gaacgcgagc tgattttcca gggtttcgta      420

ctgtttctct gttgggcggg tgccgagatg cactttagcc ccgtcgcgat gtgagaggag      480

agcacagcgg tatgacttgg cgttgttccg cagaaagtct tgccatgact cgccttccag      540

ggggcaggag tgggtatgat gcctgtccag catctcgatt ggcagggcat cgagcagggc      600

ccgcttgttc ttcacgtgcc agtacagggt aggctgctca actcccagct tttgagcgag      660

tttccttgtc gtcaggcctt cgataccgac tccattgagt aattccagag cagagtttat      720

gattttgctc ttgtccagtc tagacat                                          747


<210>  344
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  344
gaacccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agaactgctt       60

ggaggccctt ctgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      120

acccctgaag tgacctgtgt ggtggttgat gtgtcccatg aggacccaga agtgaagttc      180

aattggtatg tggatggggt tgaagtgcac aatgccaaga ccaagcctag agaggaacag      240

tacaactcca cctacagagt ggtgtctgtg ctgacagtgc tgcaccagga ctggctgaat      300

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat tgagaaaacc      360

atctccaagg ccaagggcca gccaagagaa ccccaggttt acaccctgcc acctagcaga      420

gaagagatga ccaagaacca ggtgtccctg acctgcctgg ttaagggctt ctacccctct      480

gacattgctg tggaatggga gagcaatggc cagcctgaaa acaactacaa gacaacccct      540

cctgtgctgg actcagatgg ctcattcttc ctgtacagca agctgactgt ggacaagtcc      600

aggtggcagc agggaaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac      660

tacacccaga aaagtctgag tctgagccct ggcaag                                696


<210>  345
<211>  1458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  345
gaggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctggggagag cctgaagatc       60

agctgcaaag tgtctggcta tgacttcagc aagtactgga ttggctgggt cagacagatg      120

cctggcaaag gcctggaatg gatgggactg atctaccctg gggactctga caccagatac      180

agccctagcc tggaaggcca ggtgtccatc tctgctgaca agagcatctc tgcagcctac      240

ctgcagttca gcagcctgaa ggcctctgac tctgccatgt actactgtgt cagaaagggc      300

tactctgcct accttggagg atggtttgat ccttggggcc agggcacact ggtcacagtg      360

tcctctggcg gaggtggcag cggaggtggc ggatcagaca tccagctgac acagagccct      420

gacagcctgg ctgcttctct gggagagaga gtgaccatca actgcagaag ctcccagaac      480

atcttctaca acagcaacaa caagaacttc ctggcctggt atcagcagaa ggctggccag      540

tctcctaagc tgctgatcta ctgggccagc accagagaat ctggggtgcc agatagattt      600

tctggcagtg gctctggcac agacttcacc ctgacaatca gtggactgca ggctggggat      660

gttgctgtgt acttctgcca gcagtacttc acagatgccc ctacctttgg tggtggcacc      720

aaggtggaaa tcaagggcgg aggaggcgga ggtggaggag gagaacccaa gagctgtgac      780

aagacccaca cctgtcctcc atgtcctgct ccagaactgc ttggaggccc ttctgtgttc      840

ctgtttcctc caaagcctaa ggacaccctg atgatcagca gaacccctga agtgacctgt      900

gtggtggttg atgtgtccca tgaggaccca gaagtgaagt tcaattggta tgtggatggg      960

gttgaagtgc acaatgccaa gaccaagcct agagaggaac agtacaactc cacctacaga     1020

gtggtgtctg tgctgacagt gctgcaccag gactggctga atggcaaaga gtacaagtgc     1080

aaggtgtcca acaaggccct gcctgctcct attgagaaaa ccatctccaa ggccaagggc     1140

cagccaagag aaccccaggt ttacaccctg ccacctagca gagaagagat gaccaagaac     1200

caggtgtccc tgacctgcct ggttaagggc ttctacccct ctgacattgc tgtggaatgg     1260

gagagcaatg gccagcctga aaacaactac aagacaaccc ctcctgtgct ggactcagat     1320

ggctcattct tcctgtacag caagctgact gtggacaagt ccaggtggca gcagggaaat     1380

gtgttcagct gctctgtgat gcatgaggcc ctgcacaacc actacaccca gaaaagtctg     1440

agtctgagcc ctggcaag                                                   1458


<210>  346
<211>  1488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  346
gaggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctggggagag cctgaagatc       60

agctgcaaag tgtctggcta tgacttcagc aagtactgga ttggctgggt cagacagatg      120

cctggcaaag gcctggaatg gatgggactg atctaccctg gggactctga caccagatac      180

agccctagcc tggaaggcca ggtgtccatc tctgctgaca agagcatctc tgcagcctac      240

ctgcagttca gcagcctgaa ggcctctgac tctgccatgt actactgtgt cagaaagggc      300

tactctgcct accttggagg atggtttgat ccttggggcc agggcacact ggtcacagtg      360

tcctctggtg gaggcggttc aggcggaggt ggcagcggcg gtggagggtc aggtggaggt      420

ggatcagaca tccagctgac acagagccct gacagcctgg ctgcttctct gggagagaga      480

gtgaccatca actgcagaag ctcccagaac atcttctaca acagcaacaa caagaacttc      540

ctggcctggt atcagcagaa ggctggccag tctcctaagc tgctgatcta ctgggccagc      600

accagagaat ctggggtgcc agatagattt tctggcagtg gctctggcac agacttcacc      660

ctgacaatca gtggactgca ggctggggat gttgctgtgt acttctgcca gcagtacttc      720

acagatgccc ctacctttgg tggtggcacc aaggtggaaa tcaagggcgg aggaggcgga      780

ggtggaggag gagaacccaa gagctgtgac aagacccaca cctgtcctcc atgtcctgct      840

ccagaactgc ttggaggccc ttctgtgttc ctgtttcctc caaagcctaa ggacaccctg      900

atgatcagca gaacccctga agtgacctgt gtggtggttg atgtgtccca tgaggaccca      960

gaagtgaagt tcaattggta tgtggatggg gttgaagtgc acaatgccaa gaccaagcct     1020

agagaggaac agtacaactc cacctacaga gtggtgtctg tgctgacagt gctgcaccag     1080

gactggctga atggcaaaga gtacaagtgc aaggtgtcca acaaggccct gcctgctcct     1140

attgagaaaa ccatctccaa ggccaagggc cagccaagag aaccccaggt ttacaccctg     1200

ccacctagca gagaagagat gaccaagaac caggtgtccc tgacctgcct ggttaagggc     1260

ttctacccct ctgacattgc tgtggaatgg gagagcaatg gccagcctga aaacaactac     1320

aagacaaccc ctcctgtgct ggactcagat ggctcattct tcctgtacag caagctgact     1380

gtggacaagt ccaggtggca gcagggaaat gtgttcagct gctctgtgat gcatgaggcc     1440

ctgcacaacc actacaccca gaaaagtctg agtctgagcc ctggcaag                  1488


<210>  347
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  347
gaggtgcagc tgctgcagag tggtggtggt gttgtgcagc ctggtggctc tctgagactg       60

tcttgtgaag cctctggctt caccttcagc agctacagca tgcactgggt cagacaggcc      120

cctggcaaag gactggaatg gctgaccctg atcagctaca atggggtcaa caagtactat      180

gccaagtctg tgaagggcag atttgccatc agcagagatg acagcaagtc taccctgttc      240

ctgcagatga acagcctgac cacagatgac actgctgtgt actactgtgc cagatgtccc      300

attcctagag ctgccagcta cagaaatggg gacaactact ttgagtttgg ccagggcacc      360

ctggtcacag tgtcctctgg cggaggtggc agcggaggtg gcggatcaca ggctgtggtc      420

acccaagagc ctagcctgtc tgtgtctcct ggtggcacag tgacactgac atgtgccctg      480

tcctctgcct ctgtgtctac cagcagctac cccagctggt atcagcagac acctggccag      540

cctccaagaa tgctgatcca caacacagac accagatcct ctggggtgcc agacagattc      600

tctggcagca tcctgggcaa gaaggctgcc ctgacaatca ctggtgccca ggctgatgat      660

gagtctgact actactgtgt ggtgtacctt ggcaatggct tctgggtgtt tggtggtggc      720

accaagctga cagtgctggg cggaggaggc ggaggtggag gaggagaacc caagagctgt      780

gacaagaccc acacctgtcc tccatgtcct gctccagaac tgcttggagg cccttctgtg      840

ttcctgtttc ctccaaagcc taaggacacc ctgatgatca gcagaacccc tgaagtgacc      900

tgtgtggtgg ttgatgtgtc ccatgaggac ccagaagtga agttcaattg gtatgtggat      960

ggggttgaag tgcacaatgc caagaccaag cctagagagg aacagtacaa ctccacctac     1020

agagtggtgt ctgtgctgac agtgctgcac caggactggc tgaatggcaa agagtacaag     1080

tgcaaggtgt ccaacaaggc cctgcctgct cctattgaga aaaccatctc caaggccaag     1140

ggccagccaa gagaacccca ggtttacacc ctgccaccta gcagagaaga gatgaccaag     1200

aaccaggtgt ccctgacctg cctggttaag ggcttctacc cctctgacat tgctgtggaa     1260

tgggagagca atggccagcc tgaaaacaac tacaagacaa cccctcctgt gctggactca     1320

gatggctcat tcttcctgta cagcaagctg actgtggaca agtccaggtg gcagcaggga     1380

aatgtgttca gctgctctgt gatgcatgag gccctgcaca accactacac ccagaaaagt     1440

ctgagtctga gccctggcaa g                                               1461


<210>  348
<211>  1491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  348
gaggtgcagc tgctgcagag tggtggtggt gttgtgcagc ctggtggctc tctgagactg       60

tcttgtgaag cctctggctt caccttcagc agctacagca tgcactgggt cagacaggcc      120

cctggcaaag gactggaatg gctgaccctg atcagctaca atggggtcaa caagtactat      180

gccaagtctg tgaagggcag atttgccatc agcagagatg acagcaagtc taccctgttc      240

ctgcagatga acagcctgac cacagatgac actgctgtgt actactgtgc cagatgtccc      300

attcctagag ctgccagcta cagaaatggg gacaactact ttgagtttgg ccagggcacc      360

ctggtcacag tgtcctctgg tggaggcggt tcaggcggag gtggcagcgg cggtggaggg      420

tcaggtggag gtggatcaca ggctgtggtc acccaagagc ctagcctgtc tgtgtctcct      480

ggtggcacag tgacactgac atgtgccctg tcctctgcct ctgtgtctac cagcagctac      540

cccagctggt atcagcagac acctggccag cctccaagaa tgctgatcca caacacagac      600

accagatcct ctggggtgcc agacagattc tctggcagca tcctgggcaa gaaggctgcc      660

ctgacaatca ctggtgccca ggctgatgat gagtctgact actactgtgt ggtgtacctt      720

ggcaatggct tctgggtgtt tggtggtggc accaagctga cagtgctggg cggaggaggc      780

ggaggtggag gaggagaacc caagagctgt gacaagaccc acacctgtcc tccatgtcct      840

gctccagaac tgcttggagg cccttctgtg ttcctgtttc ctccaaagcc taaggacacc      900

ctgatgatca gcagaacccc tgaagtgacc tgtgtggtgg ttgatgtgtc ccatgaggac      960

ccagaagtga agttcaattg gtatgtggat ggggttgaag tgcacaatgc caagaccaag     1020

cctagagagg aacagtacaa ctccacctac agagtggtgt ctgtgctgac agtgctgcac     1080

caggactggc tgaatggcaa agagtacaag tgcaaggtgt ccaacaaggc cctgcctgct     1140

cctattgaga aaaccatctc caaggccaag ggccagccaa gagaacccca ggtttacacc     1200

ctgccaccta gcagagaaga gatgaccaag aaccaggtgt ccctgacctg cctggttaag     1260

ggcttctacc cctctgacat tgctgtggaa tgggagagca atggccagcc tgaaaacaac     1320

tacaagacaa cccctcctgt gctggactca gatggctcat tcttcctgta cagcaagctg     1380

actgtggaca agtccaggtg gcagcaggga aatgtgttca gctgctctgt gatgcatgag     1440

gccctgcaca accactacac ccagaaaagt ctgagtctga gccctggcaa g              1491


<210>  349
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  349
gaggtgcagc tggtggaaag tggtggtgga ctggttcagc ctggtggcag cctgagactg       60

tcttgtgctg cctctggctt caccttcagc atctacacca tgagctgggt cagacaggct      120

cctggcaaag gcctggaatg ggtgtcagct atcctgtctg atggcagcac ctactatgct      180

gactctgtgg aaggcagatt caccatcagc agagacaaca gcaagaccac actgtacctg      240

cagatgaaca gcctgacagc tgaggacact gctgtgtact actgcaccaa gagagtggaa      300

ggctccttca gaggctgggg acagggaaca ctggtcactg tgtcctctgg cggaggtggc      360

agcggaggtg gcggatcaga gattgtgatg acacagagcc ctggcacact gtctctgagc      420

cctggggaat ctgccacact gagctgtaga gccagccagt ctgtgtctac cacctacctg      480

gcctggtatc agcagaagcc tggacaggct cccagactgc tgatctatgg ggcctcttct      540

agagccacag gcatccctga cagattttct ggcagtggct ctggcacaga cttcaccctg      600

accatcagca gactggaacc tgaggacttt gctgtgtact actgccagca gtatggtggc      660

agcaggctga tcacatttgg ccagggcaca agactggaaa tcaagggcgg aggaggcgga      720

ggtggaggag gagaacccaa gagctgtgac aagacccaca cctgtcctcc atgtcctgct      780

ccagaactgc ttggaggccc ttctgtgttc ctgtttcctc caaagcctaa ggacaccctg      840

atgatcagca gaacccctga agtgacctgt gtggtggttg atgtgtccca tgaggaccca      900

gaagtgaagt tcaattggta tgtggatggg gttgaagtgc acaatgccaa gaccaagcct      960

agagaggaac agtacaactc cacctacaga gtggtgtctg tgctgacagt gctgcaccag     1020

gactggctga atggcaaaga gtacaagtgc aaggtgtcca acaaggccct gcctgctcct     1080

attgagaaaa ccatctccaa ggccaagggc cagccaagag aaccccaggt ttacaccctg     1140

ccacctagca gagaagagat gaccaagaac caggtgtccc tgacctgcct ggttaagggc     1200

ttctacccct ctgacattgc tgtggaatgg gagagcaatg gccagcctga aaacaactac     1260

aagacaaccc ctcctgtgct ggactcagat ggctcattct tcctgtacag caagctgact     1320

gtggacaagt ccaggtggca gcagggaaat gtgttcagct gctctgtgat gcatgaggcc     1380

ctgcacaacc actacaccca gaaaagtctg agtctgagcc ctggcaag                  1428


<210>  350
<211>  1458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv construct

<400>  350
gaggtgcagc tggtggaaag tggtggtgga ctggttcagc ctggtggcag cctgagactg       60

tcttgtgctg cctctggctt caccttcagc atctacacca tgagctgggt cagacaggct      120

cctggcaaag gcctggaatg ggtgtcagct atcctgtctg atggcagcac ctactatgct      180

gactctgtgg aaggcagatt caccatcagc agagacaaca gcaagaccac actgtacctg      240

cagatgaaca gcctgacagc tgaggacact gctgtgtact actgcaccaa gagagtggaa      300

ggctccttca gaggctgggg acagggaaca ctggtcactg tgtcctctgg tggaggcggt      360

tcaggcggag gtggcagcgg cggtggaggg tcaggtggag gtggatcaga gattgtgatg      420

acacagagcc ctggcacact gtctctgagc cctggggaat ctgccacact gagctgtaga      480

gccagccagt ctgtgtctac cacctacctg gcctggtatc agcagaagcc tggacaggct      540

cccagactgc tgatctatgg ggcctcttct agagccacag gcatccctga cagattttct      600

ggcagtggct ctggcacaga cttcaccctg accatcagca gactggaacc tgaggacttt      660

gctgtgtact actgccagca gtatggtggc agcaggctga tcacatttgg ccagggcaca      720

agactggaaa tcaagggcgg aggaggcgga ggtggaggag gagaacccaa gagctgtgac      780

aagacccaca cctgtcctcc atgtcctgct ccagaactgc ttggaggccc ttctgtgttc      840

ctgtttcctc caaagcctaa ggacaccctg atgatcagca gaacccctga agtgacctgt      900

gtggtggttg atgtgtccca tgaggaccca gaagtgaagt tcaattggta tgtggatggg      960

gttgaagtgc acaatgccaa gaccaagcct agagaggaac agtacaactc cacctacaga     1020

gtggtgtctg tgctgacagt gctgcaccag gactggctga atggcaaaga gtacaagtgc     1080

aaggtgtcca acaaggccct gcctgctcct attgagaaaa ccatctccaa ggccaagggc     1140

cagccaagag aaccccaggt ttacaccctg ccacctagca gagaagagat gaccaagaac     1200

caggtgtccc tgacctgcct ggttaagggc ttctacccct ctgacattgc tgtggaatgg     1260

gagagcaatg gccagcctga aaacaactac aagacaaccc ctcctgtgct ggactcagat     1320

ggctcattct tcctgtacag caagctgact gtggacaagt ccaggtggca gcagggaaat     1380

gtgttcagct gctctgtgat gcatgaggcc ctgcacaacc actacaccca gaaaagtctg     1440

agtctgagcc ctggcaag                                                   1458


<210>  351
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  351

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220 


<210>  352
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  352

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val 
    210                 215                 220 


<210>  353
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  353

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220 


<210>  354
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain


<220>
<221>  misc
<222>  (229)..(234)
<223>  can be present or absent from the peptide

<220>
<221>  misc
<222>  (235)..(238)
<223>  can be present or absent from the peptide

<400>  354

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Ser 
    210                 215                 220                 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235             


<210>  355
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain


<220>
<221>  misc
<222>  (225)..(233)
<223>  can be present or absent from peptide

<220>
<221>  misc
<222>  (230)..(230)
<223>  Xaa can be proline or serine

<220>
<221>  misc
<222>  (234)..(244)
<223>  can be present or absent from peptide

<400>  355

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Xaa Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu 
                


<210>  356
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  356

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


<210>  357
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  357

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val 
    210                 215                 220                 


<210>  358
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  358

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


<210>  359
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain


<220>
<221>  misc
<222>  (232)..(237)
<223>  can be present or absent from peptide

<220>
<221>  misc
<222>  (238)..(242)
<223>  can be present or absent from peptide

<400>  359

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val 
    210                 215                 220                 


Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
225                 230                 235                 240 


Ala Gly 
        


<210>  360
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain


<220>
<221>  misc
<222>  (229)..(237)
<223>  can be present or absent from peptide

<220>
<221>  misc
<222>  (234)..(234)
<223>  Xaa can be proline or serine

<220>
<221>  misc
<222>  (238)..(248)
<223>  can be present or absent from peptide

<400>  360

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Xaa Cys Pro Ala Pro Glu Phe 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu 
                245             


<210>  361
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  361

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val 
    210                 


<210>  362
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  362

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
            180                 185                 190         


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val 
    210                 


<210>  363
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  363

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val 
    210                 


<210>  364
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain


<220>
<221>  misc
<222>  (222)..(227)
<223>  can be present or absent from peptide

<220>
<221>  misc
<222>  (228)..(232)
<223>  can be present or absent from peptide

<400>  364

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
            180                 185                 190         


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Glu Arg Lys Ser Cys Val Glu Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Pro Val Ala Gly 
225                 230         


<210>  365
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain


<220>
<221>  misc
<222>  (219)..(227)
<223>  can be present or absent from peptide

<220>
<221>  misc
<222>  (224)..(224)
<223>  Xaa can be proline or serine

<220>
<221>  misc
<222>  (228)..(238)
<223>  can be present or absent from peptide

<400>  365

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Xaa 
    210                 215                 220                 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235             


<210>  366
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  366

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    130                 135                 140                 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
145                 150                 155                 160 


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                165                 170                 175     


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            180                 185                 190         


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        195                 200                 205             


Val Glu Lys Thr Val Ala Pro Thr Cys Ser 
    210                 215             


<210>  367
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  367

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met 
        35                  40                  45              


Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn 
                85                  90                  95      


Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  368
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; antibody chain

<400>  368

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg 
                85                  90                  95      


Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Cys Ser 
    210                 


<210>  369
<211>  3859
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv-Fc construct

<400>  369
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcgccacca tgtacagaat gcagctgctg ctgctcattg ccctgtctct     1980

ggccctggtc accaattctg aggtgcagct ggtgcagtct ggggctgaag tgaagaagcc     2040

tggggagagc ctgaagatca gctgcaaagt gtctggctat gacttcagca agtactggat     2100

tggctgggtc agacagatgc ctggcaaagg cctggaatgg atgggactga tctaccctgg     2160

ggactctgac accagataca gccctagcct ggaaggccag gtgtccatct ctgctgacaa     2220

gagcatctct gcagcctacc tgcagttcag cagcctgaag gcctctgact ctgccatgta     2280

ctactgtgtc agaaagggct actctgccta ccttggagga tggtttgatc cttggggcca     2340

gggcacactg gtcacagtgt cctctggtgg aggcggttca ggcggaggtg gcagcggcgg     2400

tggagggtcg gacatccagc tgacacagag ccctgacagc ctggctgctt ctctgggaga     2460

gagagtgacc atcaactgca gaagctccca gaacatcttc tacaacagca acaacaagaa     2520

cttcctggcc tggtatcagc agaaggctgg ccagtctcct aagctgctga tctactgggc     2580

cagcaccaga gaatctgggg tgccagatag attttctggc agtggctctg gcacagactt     2640

caccctgaca atcagtggac tgcaggctgg ggatgttgct gtgtacttct gccagcagta     2700

cttcacagat gcccctacct ttggtggtgg caccaaggtg gaaatcaagg gcggaggagg     2760

cggaggtgga ggaggagagc ctagaggccc caccatcaag ccctgtcctc catgcaagtg     2820

tcctgctcct aacctgcttg gaggcccctc tgtgttcatc ttcccaccta agatcaagga     2880

tgtgctgatg atctctctga gccccattgt gacctgtgtg gtggtggatg tgtctgagga     2940

tgaccctgat gtgcagatct cttggtttgt gaacaatgtg gaagtgcaca cagcccagac     3000

acagacccac agagaggact acaacagcac cctgagagtg gtgtctgccc tgcctatcca     3060

gcaccaggac tggatgagtg gcaaagagtt caagtgcaaa gtgaacaaca aggacctgcc     3120

tgctccaatt gagagaacca tcagcaagcc caagggctct gttagagccc ctcaagtgta     3180

tgtgctgcct ccacctgagg aagagatgac caagaaacaa gtgaccctga catgcatggt     3240

cacagacttc atgcctgagg acatctatgt ggaatggacc aacaatggca agacagagct     3300

gaactacaag aacactgagc ctgtgctgga ctctgatggc agctacttca tgtacagcaa     3360

gctgagggtt gagaagaaga actgggttga gagaaacagc tacagctgct ctgtggtgca     3420

tgagggcctg cacaatcacc acaccaccaa gagcttcagc agaacccctg gcaagtaatg     3480

actcgaggac ggggtgaact acgcctgagg atccgatctt tttccctctg ccaaaaatta     3540

tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt     3600

cattgcaata gtgtgttgga attttttgtg tctctcactc ggaagcaatt cgttgatctg     3660

aatttcgacc acccataata cccattaccc tggtagataa gtagcatggc gggttaatca     3720

ttaactacaa ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc     3780

tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag     3840

tgagcgagcg agcgcgcag                                                  3859


<210>  370
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv-Fc construct

<400>  370
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctggggagag cctgaagatc      120

agctgcaaag tgtctggcta tgacttcagc aagtactgga ttggctgggt cagacagatg      180

cctggcaaag gcctggaatg gatgggactg atctaccctg gggactctga caccagatac      240

agccctagcc tggaaggcca ggtgtccatc tctgctgaca agagcatctc tgcagcctac      300

ctgcagttca gcagcctgaa ggcctctgac tctgccatgt actactgtgt cagaaagggc      360

tactctgcct accttggagg atggtttgat ccttggggcc agggcacact ggtcacagtg      420

tcctctggtg gaggcggttc aggcggaggt ggcagcggcg gtggagggtc ggacatccag      480

ctgacacaga gccctgacag cctggctgct tctctgggag agagagtgac catcaactgc      540

agaagctccc agaacatctt ctacaacagc aacaacaaga acttcctggc ctggtatcag      600

cagaaggctg gccagtctcc taagctgctg atctactggg ccagcaccag agaatctggg      660

gtgccagata gattttctgg cagtggctct ggcacagact tcaccctgac aatcagtgga      720

ctgcaggctg gggatgttgc tgtgtacttc tgccagcagt acttcacaga tgcccctacc      780

tttggtggtg gcaccaaggt ggaaatcaag ggcggaggag gcggaggtgg aggaggagag      840

cctagaggcc ccaccatcaa gccctgtcct ccatgcaagt gtcctgctcc taacctgctt      900

ggaggcccct ctgtgttcat cttcccacct aagatcaagg atgtgctgat gatctctctg      960

agccccattg tgacctgtgt ggtggtggat gtgtctgagg atgaccctga tgtgcagatc     1020

tcttggtttg tgaacaatgt ggaagtgcac acagcccaga cacagaccca cagagaggac     1080

tacaacagca ccctgagagt ggtgtctgcc ctgcctatcc agcaccagga ctggatgagt     1140

ggcaaagagt tcaagtgcaa agtgaacaac aaggacctgc ctgctccaat tgagagaacc     1200

atcagcaagc ccaagggctc tgttagagcc cctcaagtgt atgtgctgcc tccacctgag     1260

gaagagatga ccaagaaaca agtgaccctg acatgcatgg tcacagactt catgcctgag     1320

gacatctatg tggaatggac caacaatggc aagacagagc tgaactacaa gaacactgag     1380

cctgtgctgg actctgatgg cagctacttc atgtacagca agctgagggt tgagaagaag     1440

aactgggttg agagaaacag ctacagctgc tctgtggtgc atgagggcct gcacaatcac     1500

cacaccacca agagcttcag cagaacccct ggcaag                               1536


<210>  371
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv-Fc polypeptide

<400>  371

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp 
        35                  40                  45              


Phe Ser Lys Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr 
65                  70                  75                  80  


Ser Pro Ser Leu Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile 
                85                  90                  95      


Ser Ala Ala Tyr Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala 
            100                 105                 110         


Met Tyr Tyr Cys Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp 
        115                 120                 125             


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly Glu Arg Val 
                165                 170                 175     


Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn Ser Asn Asn 
            180                 185                 190         


Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly 
225                 230                 235                 240 


Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln Tyr Phe Thr 
                245                 250                 255     


Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro 
        275                 280                 285             


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser 
    290                 295                 300                 


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
305                 310                 315                 320 


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
                325                 330                 335     


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
            340                 345                 350         


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
        355                 360                 365             


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
    370                 375                 380                 


Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr 
385                 390                 395                 400 


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
                405                 410                 415     


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
            420                 425                 430         


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
        435                 440                 445             


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
    450                 455                 460                 


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
465                 470                 475                 480 


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
                485                 490                 495     


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            500                 505                 510         


<210>  372
<211>  3862
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv-Fc construct

<400>  372
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcgccacca tgtacagaat gcagctgctg ctgctcattg ccctgtctct     1980

ggccctggtc accaattctg aggtgcagct gctgcagagt ggtggtggtg ttgtgcagcc     2040

tggtggctct ctgagactgt cttgtgaagc ctctggcttc accttcagca gctacagcat     2100

gcactgggtc agacaggccc ctggcaaagg actggaatgg ctgaccctga tcagctacaa     2160

tggggtcaac aagtactatg ccaagtctgt gaagggcaga tttgccatca gcagagatga     2220

cagcaagtct accctgttcc tgcagatgaa cagcctgacc acagatgaca ctgctgtgta     2280

ctactgtgcc agatgtccca ttcctagagc tgccagctac agaaatgggg acaactactt     2340

tgagtttggc cagggcaccc tggtcacagt gtcctctggt ggaggcggtt caggcggagg     2400

tggcagcggc ggtggagggt cgcaggctgt ggtcacccaa gagcctagcc tgtctgtgtc     2460

tcctggtggc acagtgacac tgacatgtgc cctgtcctct gcctctgtgt ctaccagcag     2520

ctaccccagc tggtatcagc agacacctgg ccagcctcca agaatgctga tccacaacac     2580

agacaccaga tcctctgggg tgccagacag attctctggc agcatcctgg gcaagaaggc     2640

tgccctgaca atcactggtg cccaggctga tgatgagtct gactactact gtgtggtgta     2700

ccttggcaat ggcttctggg tgtttggtgg tggcaccaag ctgacagtgc tgggcggagg     2760

aggcggaggt ggaggaggag agcctagagg ccccaccatc aagccctgtc ctccatgcaa     2820

gtgtcctgct cctaacctgc ttggaggccc ctctgtgttc atcttcccac ctaagatcaa     2880

ggatgtgctg atgatctctc tgagccccat tgtgacctgt gtggtggtgg atgtgtctga     2940

ggatgaccct gatgtgcaga tctcttggtt tgtgaacaat gtggaagtgc acacagccca     3000

gacacagacc cacagagagg actacaacag caccctgaga gtggtgtctg ccctgcctat     3060

ccagcaccag gactggatga gtggcaaaga gttcaagtgc aaagtgaaca acaaggacct     3120

gcctgctcca attgagagaa ccatcagcaa gcccaagggc tctgttagag cccctcaagt     3180

gtatgtgctg cctccacctg aggaagagat gaccaagaaa caagtgaccc tgacatgcat     3240

ggtcacagac ttcatgcctg aggacatcta tgtggaatgg accaacaatg gcaagacaga     3300

gctgaactac aagaacactg agcctgtgct ggactctgat ggcagctact tcatgtacag     3360

caagctgagg gttgagaaga agaactgggt tgagagaaac agctacagct gctctgtggt     3420

gcatgagggc ctgcacaatc accacaccac caagagcttc agcagaaccc ctggcaagta     3480

atgactcgag gacggggtga actacgcctg aggatccgat ctttttccct ctgccaaaaa     3540

ttatggggac atcatgaagc cccttgagca tctgacttct ggctaataaa ggaaatttat     3600

tttcattgca atagtgtgtt ggaatttttt gtgtctctca ctcggaagca attcgttgat     3660

ctgaatttcg accacccata atacccatta ccctggtaga taagtagcat ggcgggttaa     3720

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     3780

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     3840

cagtgagcga gcgagcgcgc ag                                              3862


<210>  373
<211>  1539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv-Fc construct

<400>  373
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggtgcagc tgctgcagag tggtggtggt gttgtgcagc ctggtggctc tctgagactg      120

tcttgtgaag cctctggctt caccttcagc agctacagca tgcactgggt cagacaggcc      180

cctggcaaag gactggaatg gctgaccctg atcagctaca atggggtcaa caagtactat      240

gccaagtctg tgaagggcag atttgccatc agcagagatg acagcaagtc taccctgttc      300

ctgcagatga acagcctgac cacagatgac actgctgtgt actactgtgc cagatgtccc      360

attcctagag ctgccagcta cagaaatggg gacaactact ttgagtttgg ccagggcacc      420

ctggtcacag tgtcctctgg tggaggcggt tcaggcggag gtggcagcgg cggtggaggg      480

tcgcaggctg tggtcaccca agagcctagc ctgtctgtgt ctcctggtgg cacagtgaca      540

ctgacatgtg ccctgtcctc tgcctctgtg tctaccagca gctaccccag ctggtatcag      600

cagacacctg gccagcctcc aagaatgctg atccacaaca cagacaccag atcctctggg      660

gtgccagaca gattctctgg cagcatcctg ggcaagaagg ctgccctgac aatcactggt      720

gcccaggctg atgatgagtc tgactactac tgtgtggtgt accttggcaa tggcttctgg      780

gtgtttggtg gtggcaccaa gctgacagtg ctgggcggag gaggcggagg tggaggagga      840

gagcctagag gccccaccat caagccctgt cctccatgca agtgtcctgc tcctaacctg      900

cttggaggcc cctctgtgtt catcttccca cctaagatca aggatgtgct gatgatctct      960

ctgagcccca ttgtgacctg tgtggtggtg gatgtgtctg aggatgaccc tgatgtgcag     1020

atctcttggt ttgtgaacaa tgtggaagtg cacacagccc agacacagac ccacagagag     1080

gactacaaca gcaccctgag agtggtgtct gccctgccta tccagcacca ggactggatg     1140

agtggcaaag agttcaagtg caaagtgaac aacaaggacc tgcctgctcc aattgagaga     1200

accatcagca agcccaaggg ctctgttaga gcccctcaag tgtatgtgct gcctccacct     1260

gaggaagaga tgaccaagaa acaagtgacc ctgacatgca tggtcacaga cttcatgcct     1320

gaggacatct atgtggaatg gaccaacaat ggcaagacag agctgaacta caagaacact     1380

gagcctgtgc tggactctga tggcagctac ttcatgtaca gcaagctgag ggttgagaag     1440

aagaactggg ttgagagaaa cagctacagc tgctctgtgg tgcatgaggg cctgcacaat     1500

caccacacca ccaagagctt cagcagaacc cctggcaag                            1539


<210>  374
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv-Fc polypeptide

<400>  374

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Leu Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr 
65                  70                  75                  80  


Ala Lys Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys 
                85                  90                  95      


Ser Thr Leu Phe Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg 
        115                 120                 125             


Asn Gly Asp Asn Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly 
                165                 170                 175     


Gly Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr 
            180                 185                 190         


Ser Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg 
        195                 200                 205             


Met Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly 
225                 230                 235                 240 


Ala Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly 
                245                 250                 255     


Asn Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys 
        275                 280                 285             


Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro 
    290                 295                 300                 


Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser 
305                 310                 315                 320 


Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp 
                325                 330                 335     


Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr 
            340                 345                 350         


Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val 
        355                 360                 365             


Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu 
    370                 375                 380                 


Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg 
385                 390                 395                 400 


Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val 
                405                 410                 415     


Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr 
            420                 425                 430         


Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr 
        435                 440                 445             


Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu 
    450                 455                 460                 


Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys 
465                 470                 475                 480 


Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu 
                485                 490                 495     


Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly 
            500                 505                 510         


Lys 
    


<210>  375
<211>  3856
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv-Fc construct

<400>  375
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcgccacca tgtacagaat gcagctgctg ctgctcattg ccctgtctct     1980

ggccctggtc accaattctc aggtccagct gcaagagtct ggccctggac tggtcaagcc     2040

ttctggcaca ctgagcctga cctgtgctgt gactggtggc agcatcagca gcagcaattg     2100

gtggtcttgg gtcagacaga gccctggcaa aggcctggaa tggattggag agatccacca     2160

tgatggcaac ctgaactaca accctctgct gaagtccaga gtgtccatga gcctggacag     2220

aagcaagaac cagttcagcc tgaagctgac ctctgtgaca gctgctgaca ctgctgtgta     2280

ctactgtgcc agatgggact tcttctttga ctcctcctac tacatcaggg gctttgacct     2340

gtggggccag ggcacaatgg ttacagtgtc ctctggtgga ggcggttcag gcggaggtgg     2400

cagcggcggt ggagggtcgg agacaaccct gacacagagc cctggcacat tgtctctgag     2460

ccctggggag agagtgaccc tgtcttgtag agccagccag tctgtggaca gaaactacct     2520

ggcctggtat cagcagaagc ctggccagtc tcctagactg ctgatctact ctgcctctag     2580

gagagccaca ggcatccctg acagattttc tggcagtggc tctggcacag acttcaccct     2640

gaccatcagc agactggaac ctgaggactt tgtggtgtac tactgccagc agtatggtgg     2700

cagccctcct atcacatttg gccagggcac aagactggaa atcaagggcg gaggaggcgg     2760

aggtggagga ggagagccta gaggccccac catcaagccc tgtcctccat gcaagtgtcc     2820

tgctcctaac ctgcttggag gcccctctgt gttcatcttc ccacctaaga tcaaggatgt     2880

gctgatgatc tctctgagcc ccattgtgac ctgtgtggtg gtggatgtgt ctgaggatga     2940

ccctgatgtg cagatctctt ggtttgtgaa caatgtggaa gtgcacacag cccagacaca     3000

gacccacaga gaggactaca acagcaccct gagagtggtg tctgccctgc ctatccagca     3060

ccaggactgg atgagtggca aagagttcaa gtgcaaagtg aacaacaagg acctgcctgc     3120

tccaattgag agaaccatca gcaagcccaa gggctctgtt agagcccctc aagtgtatgt     3180

gctgcctcca cctgaggaag agatgaccaa gaaacaagtg accctgacat gcatggtcac     3240

agacttcatg cctgaggaca tctatgtgga atggaccaac aatggcaaga cagagctgaa     3300

ctacaagaac actgagcctg tgctggactc tgatggcagc tacttcatgt acagcaagct     3360

gagggttgag aagaagaact gggttgagag aaacagctac agctgctctg tggtgcatga     3420

gggcctgcac aatcaccaca ccaccaagag cttcagcaga acccctggca agtaatgact     3480

cgaggacggg gtgaactacg cctgaggatc cgatcttttt ccctctgcca aaaattatgg     3540

ggacatcatg aagccccttg agcatctgac ttctggctaa taaaggaaat ttattttcat     3600

tgcaatagtg tgttggaatt ttttgtgtct ctcactcgga agcaattcgt tgatctgaat     3660

ttcgaccacc cataataccc attaccctgg tagataagta gcatggcggg ttaatcatta     3720

actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     3780

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     3840

gcgagcgagc gcgcag                                                     3856


<210>  376
<211>  1533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv-Fc construct

<400>  376
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

caggtccagc tgcaagagtc tggccctgga ctggtcaagc cttctggcac actgagcctg      120

acctgtgctg tgactggtgg cagcatcagc agcagcaatt ggtggtcttg ggtcagacag      180

agccctggca aaggcctgga atggattgga gagatccacc atgatggcaa cctgaactac      240

aaccctctgc tgaagtccag agtgtccatg agcctggaca gaagcaagaa ccagttcagc      300

ctgaagctga cctctgtgac agctgctgac actgctgtgt actactgtgc cagatgggac      360

ttcttctttg actcctccta ctacatcagg ggctttgacc tgtggggcca gggcacaatg      420

gttacagtgt cctctggtgg aggcggttca ggcggaggtg gcagcggcgg tggagggtcg      480

gagacaaccc tgacacagag ccctggcaca ttgtctctga gccctgggga gagagtgacc      540

ctgtcttgta gagccagcca gtctgtggac agaaactacc tggcctggta tcagcagaag      600

cctggccagt ctcctagact gctgatctac tctgcctcta ggagagccac aggcatccct      660

gacagatttt ctggcagtgg ctctggcaca gacttcaccc tgaccatcag cagactggaa      720

cctgaggact ttgtggtgta ctactgccag cagtatggtg gcagccctcc tatcacattt      780

ggccagggca caagactgga aatcaagggc ggaggaggcg gaggtggagg aggagagcct      840

agaggcccca ccatcaagcc ctgtcctcca tgcaagtgtc ctgctcctaa cctgcttgga      900

ggcccctctg tgttcatctt cccacctaag atcaaggatg tgctgatgat ctctctgagc      960

cccattgtga cctgtgtggt ggtggatgtg tctgaggatg accctgatgt gcagatctct     1020

tggtttgtga acaatgtgga agtgcacaca gcccagacac agacccacag agaggactac     1080

aacagcaccc tgagagtggt gtctgccctg cctatccagc accaggactg gatgagtggc     1140

aaagagttca agtgcaaagt gaacaacaag gacctgcctg ctccaattga gagaaccatc     1200

agcaagccca agggctctgt tagagcccct caagtgtatg tgctgcctcc acctgaggaa     1260

gagatgacca agaaacaagt gaccctgaca tgcatggtca cagacttcat gcctgaggac     1320

atctatgtgg aatggaccaa caatggcaag acagagctga actacaagaa cactgagcct     1380

gtgctggact ctgatggcag ctacttcatg tacagcaagc tgagggttga gaagaagaac     1440

tgggttgaga gaaacagcta cagctgctct gtggtgcatg agggcctgca caatcaccac     1500

accaccaaga gcttcagcag aacccctggc aag                                  1533


<210>  377
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; scFv-Fc polypeptide

<400>  377

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Lys Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala Val Thr Gly Gly Ser 
        35                  40                  45              


Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Glu Ile His His Asp Gly Asn Leu Asn Tyr 
65                  70                  75                  80  


Asn Pro Leu Leu Lys Ser Arg Val Ser Met Ser Leu Asp Arg Ser Lys 
                85                  90                  95      


Asn Gln Phe Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Trp Asp Phe Phe Phe Asp Ser Ser Tyr Tyr 
        115                 120                 125             


Ile Arg Gly Phe Asp Leu Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
                165                 170                 175     


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Arg Asn 
            180                 185                 190         


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu 
        195                 200                 205             


Ile Tyr Ser Ala Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
225                 230                 235                 240 


Pro Glu Asp Phe Val Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Pro 
                245                 250                 255     


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys 
        275                 280                 285             


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
    290                 295                 300                 


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
305                 310                 315                 320 


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
                325                 330                 335     


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
            340                 345                 350         


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
        355                 360                 365             


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
    370                 375                 380                 


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
385                 390                 395                 400 


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
                405                 410                 415     


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
            420                 425                 430         


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
        435                 440                 445             


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
    450                 455                 460                 


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
465                 470                 475                 480 


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
                485                 490                 495     


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            500                 505                 510     


<210>  378
<211>  3865
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Fab construct

<400>  378
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcgccacca tgtacagaat gcagctgctg ctgctcattg ccctgtctct     1980

ggccctggtc accaattctg aagtgcagct ggtgcagtct ggggctgaag tgaagaagcc     2040

tggggagagc ctgaagatca gctgcaaagt gtctggctat gacttcagca agtactggat     2100

tggctgggtc agacagatgc ctggcaaagg cctggaatgg atgggcctga tctaccctgg     2160

ggactctgac accagataca gccctagcct ggaaggccag gtgtccatct ctgctgacaa     2220

gagcatctct gcagcctacc tgcagttcag cagcctgaag gcctctgact ctgccatgta     2280

ctactgtgtc agaaagggct actctgccta ccttggagga tggtttgatc cttggggcca     2340

gggcacactg gttacagtgt cctctgccag cacaaagggc ccctctgttt ttccactggc     2400

tcccagcagc aagtccacca gtggtggtac agctgccctg ggctgtctgg tcaaggatta     2460

cttccctgag cctgtgactg tgtcctggaa ctctggtgct ctgacctctg gggtgcacac     2520

ctttccagct gtgctgcagt cctctggcct gtactctctg tcctctgtgg tcacagtgcc     2580

tagctctagc ctgggcaccc agacctacat ctgcaatgtg aaccacaagc ctagcaacac     2640

caaggtggac aagagagtgg aacccaagag ctgtgacaag acccacagaa agagaagagg     2700

ctctggagaa ggcagaggct ccctgctgac atgtggggat gttgaagaga atcctgggcc     2760

tatgtatagg atgcaactgc tcctcctgat tgctctgagc ctggctcttg tgaccaactc     2820

tgatatccag ctgacacaga gccctgacag cctggctgct tctctgggag agagagtgac     2880

catcaactgc agaagctccc agaacatctt ctacaactcc aacaacaaga acttcctggc     2940

ctggtatcag caaaaggctg gacagagccc caagctgctg atctactggg cctctaccag     3000

agagtctggg gtcccagaca gattctctgg ctctggatct ggcacagact tcaccctgac     3060

catcagtgga ctgcaggctg gggatgttgc tgtgtacttc tgccagcagt acttcacaga     3120

tgcccctacc tttggtggtg gcacaaaggt ggaaatcaag agaacagtgg ctgccccatc     3180

tgtgttcatc ttcccaccat ctgatgaaca gctgaagtct ggcactgcct ctgttgtgtg     3240

cctgctgaac aacttctacc ctagagaagc caaggtgcag tggaaagtgg ataatgccct     3300

ccagtctggc aatagccaag agtcagtgac agagcaggac tccaaggatt ccacctacag     3360

cctgagcagc accctgacac tgagcaaggc tgactatgag aagcacaaag tgtatgcctg     3420

tgaagtgaca caccagggac tgagcagccc agtgaccaag agcttcaaca ggggagagtg     3480

ctgataactc gaggacgggg tgaactacgc ctgaggatcc gatctttttc cctctgccaa     3540

aaattatggg gacatcatga agccccttga gcatctgact tctggctaat aaaggaaatt     3600

tattttcatt gcaatagtgt gttggaattt tttgtgtctc tcactcggaa gcaattcgtt     3660

gatctgaatt tcgaccaccc ataataccca ttaccctggt agataagtag catggcgggt     3720

taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc     3780

gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg     3840

cctcagtgag cgagcgagcg cgcag                                           3865


<210>  379
<211>  1545
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Fab construct

<400>  379
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaagtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctggggagag cctgaagatc      120

agctgcaaag tgtctggcta tgacttcagc aagtactgga ttggctgggt cagacagatg      180

cctggcaaag gcctggaatg gatgggcctg atctaccctg gggactctga caccagatac      240

agccctagcc tggaaggcca ggtgtccatc tctgctgaca agagcatctc tgcagcctac      300

ctgcagttca gcagcctgaa ggcctctgac tctgccatgt actactgtgt cagaaagggc      360

tactctgcct accttggagg atggtttgat ccttggggcc agggcacact ggttacagtg      420

tcctctgcca gcacaaaggg cccctctgtt tttccactgg ctcccagcag caagtccacc      480

agtggtggta cagctgccct gggctgtctg gtcaaggatt acttccctga gcctgtgact      540

gtgtcctgga actctggtgc tctgacctct ggggtgcaca cctttccagc tgtgctgcag      600

tcctctggcc tgtactctct gtcctctgtg gtcacagtgc ctagctctag cctgggcacc      660

cagacctaca tctgcaatgt gaaccacaag cctagcaaca ccaaggtgga caagagagtg      720

gaacccaaga gctgtgacaa gacccacaga aagagaagag gctctggaga aggcagaggc      780

tccctgctga catgtgggga tgttgaagag aatcctgggc ctatgtatag gatgcaactg      840

ctcctcctga ttgctctgag cctggctctt gtgaccaact ctgatatcca gctgacacag      900

agccctgaca gcctggctgc ttctctggga gagagagtga ccatcaactg cagaagctcc      960

cagaacatct tctacaactc caacaacaag aacttcctgg cctggtatca gcaaaaggct     1020

ggacagagcc ccaagctgct gatctactgg gcctctacca gagagtctgg ggtcccagac     1080

agattctctg gctctggatc tggcacagac ttcaccctga ccatcagtgg actgcaggct     1140

ggggatgttg ctgtgtactt ctgccagcag tacttcacag atgcccctac ctttggtggt     1200

ggcacaaagg tggaaatcaa gagaacagtg gctgccccat ctgtgttcat cttcccacca     1260

tctgatgaac agctgaagtc tggcactgcc tctgttgtgt gcctgctgaa caacttctac     1320

cctagagaag ccaaggtgca gtggaaagtg gataatgccc tccagtctgg caatagccaa     1380

gagtcagtga cagagcagga ctccaaggat tccacctaca gcctgagcag caccctgaca     1440

ctgagcaagg ctgactatga gaagcacaaa gtgtatgcct gtgaagtgac acaccaggga     1500

ctgagcagcc cagtgaccaa gagcttcaac aggggagagt gctga                     1545


<210>  380
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain with signal peptide

<400>  380

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp 
        35                  40                  45              


Phe Ser Lys Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr 
65                  70                  75                  80  


Ser Pro Ser Leu Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile 
                85                  90                  95      


Ser Ala Ala Tyr Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala 
            100                 105                 110         


Met Tyr Tyr Cys Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp 
        115                 120                 125             


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 


<210>  381
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain no signal peptide

<400>  381

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His 
225                 


<210>  382
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain with signal peptide

<400>  382

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn 
        35                  40                  45              


Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr 
            100                 105                 110         


Phe Cys Gln Gln Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  383
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain with no signal peptide

<400>  383

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  384
<211>  3835
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Fab

<400>  384
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcgccacca tgtacagaat gcagctgctg ctgctcattg ccctgtctct     1980

ggccctggtc accaattctg aagtgcagct ggtggaaagt ggtggtggac tggttcagcc     2040

tggtggcagc ctgagactgt cttgtgctgc ctctggcttc accttcagca tctacaccat     2100

gagctgggtc agacaggccc ctggcaaagg actggaatgg gtgtcagcca tcctgtctga     2160

tggcagcacc tactatgctg actctgtgga aggcagattc accatcagca gagacaacag     2220

caagaccaca ctgtacctgc agatgaacag cctgacagct gaggacacag cagtgtacta     2280

ctgcaccaag agagtggaag gctccttcag aggctggggc cagggaacac tggttacagt     2340

gtcctctgcc agcacaaagg gcccctctgt ttttccactg gctcccagca gcaagagcac     2400

cagtggtgga acagctgccc tgggctgtct ggtcaaggat tacttccctg agcctgtgac     2460

tgtgtcctgg aactctggtg cactgacctc tggggtgcac acctttccag ctgtgctgca     2520

gtcctctggc ctgtactctc tgtcctctgt ggtcacagtg cctagctcta gcctgggcac     2580

ccagacctac atctgcaatg tgaaccacaa gcctagcaac accaaggtgg acaaaagagt     2640

ggaacccaag agctgtgaca agacccacag aaagagaaga ggctctggag aaggcagagg     2700

ctccctgctg acatgtgggg atgttgaaga gaatcctggg cctatgtata ggatgcaact     2760

gctcctcctg attgctctga gcctggctct tgtgaccaac tctgagattg tgatgacaca     2820

gagcccaggc acactgtcac tgtctccagg ggaatctgcc actctgagct gtagagccag     2880

ccagtctgtg tctaccacct acctggcctg gtatcagcaa aagcctggac aggctcccag     2940

actgctgatc tatggggcct cttctagagc cacaggcatc cctgacagat tttctggcag     3000

tggctctggc acagacttca ccctgaccat ctctagactg gaacctgagg actttgctgt     3060

ctactactgc cagcagtatg gtggctccag actgatcacc tttggccagg gcaccagact     3120

ggaaatcaag agaacagtgg ctgccccatc tgtgttcatc ttcccaccat ctgatgagca     3180

gctcaagtct ggcactgcct ctgttgtgtg cctgctgaac aacttctacc ctagagaagc     3240

caaggtgcag tggaaggttg acaatgccct gcagtctggc aatagccaag aatctgtgac     3300

agagcaggac tccaaggata gcacctacag cctgtctagc accctgacac tgagcaaggc     3360

tgactatgag aagcacaaag tgtatgcctg tgaagtgaca caccagggcc tgagcagccc     3420

agtgaccaag agcttcaata gaggggagtg ctgataactc gaggacgggg tgaactacgc     3480

ctgaggatcc gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga     3540

gcatctgact tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt     3600

tttgtgtctc tcactcggaa gcaattcgtt gatctgaatt tcgaccaccc ataataccca     3660

ttaccctggt agataagtag catggcgggt taatcattaa ctacaaggaa cccctagtga     3720

tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg     3780

tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcag          3835


<210>  385
<211>  1512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Fab

<400>  385
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaagtgcagc tggtggaaag tggtggtgga ctggttcagc ctggtggcag cctgagactg      120

tcttgtgctg cctctggctt caccttcagc atctacacca tgagctgggt cagacaggcc      180

cctggcaaag gactggaatg ggtgtcagcc atcctgtctg atggcagcac ctactatgct      240

gactctgtgg aaggcagatt caccatcagc agagacaaca gcaagaccac actgtacctg      300

cagatgaaca gcctgacagc tgaggacaca gcagtgtact actgcaccaa gagagtggaa      360

ggctccttca gaggctgggg ccagggaaca ctggttacag tgtcctctgc cagcacaaag      420

ggcccctctg tttttccact ggctcccagc agcaagagca ccagtggtgg aacagctgcc      480

ctgggctgtc tggtcaagga ttacttccct gagcctgtga ctgtgtcctg gaactctggt      540

gcactgacct ctggggtgca cacctttcca gctgtgctgc agtcctctgg cctgtactct      600

ctgtcctctg tggtcacagt gcctagctct agcctgggca cccagaccta catctgcaat      660

gtgaaccaca agcctagcaa caccaaggtg gacaaaagag tggaacccaa gagctgtgac      720

aagacccaca gaaagagaag aggctctgga gaaggcagag gctccctgct gacatgtggg      780

gatgttgaag agaatcctgg gcctatgtat aggatgcaac tgctcctcct gattgctctg      840

agcctggctc ttgtgaccaa ctctgagatt gtgatgacac agagcccagg cacactgtca      900

ctgtctccag gggaatctgc cactctgagc tgtagagcca gccagtctgt gtctaccacc      960

tacctggcct ggtatcagca aaagcctgga caggctccca gactgctgat ctatggggcc     1020

tcttctagag ccacaggcat ccctgacaga ttttctggca gtggctctgg cacagacttc     1080

accctgacca tctctagact ggaacctgag gactttgctg tctactactg ccagcagtat     1140

ggtggctcca gactgatcac ctttggccag ggcaccagac tggaaatcaa gagaacagtg     1200

gctgccccat ctgtgttcat cttcccacca tctgatgagc agctcaagtc tggcactgcc     1260

tctgttgtgt gcctgctgaa caacttctac cctagagaag ccaaggtgca gtggaaggtt     1320

gacaatgccc tgcagtctgg caatagccaa gaatctgtga cagagcagga ctccaaggat     1380

agcacctaca gcctgtctag caccctgaca ctgagcaagg ctgactatga gaagcacaaa     1440

gtgtatgcct gtgaagtgac acaccagggc ctgagcagcc cagtgaccaa gagcttcaat     1500

agaggggagt gc                                                         1512


<210>  386
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain with signal peptide

<400>  386

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ile Tyr Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His 
            


<210>  387
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain no signal peptide

<400>  387

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220             


<210>  388
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain with signal peptide

<400>  388

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Thr Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Gly Ser Arg Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  389
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain with no signal peptide

<400>  389

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg 
                85                  90                  95      


Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  390
<211>  3859
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Fab

<400>  390
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcatgtaca ggatgcagct gctgctgctc attgccctgt ctctggccct     1980

ggtcaccaat tctgaagtgc agcttctgca gtctggtggt ggtgttgtgc agcctggtgg     2040

ctctctgaga ctgtcttgtg aagcctctgg cttcaccttc agcagctaca gcatgcactg     2100

ggttagacag gcccctggca aaggcctgga atggctgacc ctgatcagct acaatggggt     2160

caacaagtac tatgccaagt ctgtgaaggg cagatttgcc atcagcagag atgacagcaa     2220

gagcaccctg tttctgcaga tgaacagcct gaccacagat gacacagcag tgtactactg     2280

tgccagatgt cccattccta gagctgccag ctacagaaat ggggacaact actttgagtt     2340

tggccagggc acactggtca cagtgtcctc tgcctctaca aagggcccct ctgtgtttcc     2400

tctggctcct agcagcaagt ccaccagtgg tggtacagct gccctgggct gtctggtcaa     2460

ggattacttc cctgagcctg tgactgtgtc ctggaattct ggggctctga cctctggggt     2520

gcacaccttt ccagctgtgc tgcagtcctc tggcctgtac tctctgtcct ctgtggttac     2580

agtgccaagc agctctctgg gcacccagac ctacatctgc aatgtgaacc acaagcctag     2640

caacaccaag gtggacaaga gagtggaacc caagagctgt gacaagaccc acagaaagag     2700

aagaggctct ggagaaggca gaggcagcct gctgacatgt ggggatgttg aagagaatcc     2760

tgggcctatg tatagaatgc aactgctcct cctgattgct ctgagcctgg ctctggttac     2820

caacagccag gctgtggtca cacaagagcc cagcctgtct gtgtctcctg gtggaacagt     2880

gaccctgact tgtgccctct cttctgcctc tgtgtccaca agcagctacc ccagctggta     2940

tcagcagaca cctggccagc cacctagaat gctgatccac aacactgaca ccagaagctc     3000

tggggtccca gacagattct ctggcagcat cctgggaaag aaggctgccc tgacaatcac     3060

tggtgcccag gctgatgatg agtctgacta ctattgtgtg gtgtaccttg gcaatggctt     3120

ttgggtgttc ggtggtggca ccaaactgac tgtgctggga cagcctaaag ctgccccttc     3180

tgtgacactg ttcccaccta gctctgagga actgcaggcc aacaaagcca cacttgtgtg     3240

cctgatctct gacttctacc ctggggctgt gacagtggct tggaaggctg atagcagccc     3300

tgtgaaggct ggggttgaga caaccacacc tagcaagcag agcaacaaca aatatgctgc     3360

ctccagctat ctgtctctga cccctgagca gtggaagtcc cacagatcct acagctgtca     3420

agtgacccat gagggctcca cagtggaaaa gacagtggcc ccaacagagt gcagctgatg     3480

actcgaggac ggggtgaact acgcctgagg atccgatctt tttccctctg ccaaaaatta     3540

tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt     3600

cattgcaata gtgtgttgga attttttgtg tctctcactc ggaagcaatt cgttgatctg     3660

aatttcgacc acccataata cccattaccc tggtagataa gtagcatggc gggttaatca     3720

ttaactacaa ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc     3780

tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag     3840

tgagcgagcg agcgcgcag                                                  3859


<210>  391
<211>  1542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Fab

<400>  391

Ala Thr Gly Thr Ala Cys Ala Gly Gly Ala Thr Gly Cys Ala Gly Cys 
1               5                   10                  15      


Thr Gly Cys Thr Gly Cys Thr Gly Cys Thr Cys Ala Thr Thr Gly Cys 
            20                  25                  30          


Cys Cys Thr Gly Thr Cys Thr Cys Thr Gly Gly Cys Cys Cys Thr Gly 
        35                  40                  45              


Gly Thr Cys Ala Cys Cys Ala Ala Thr Thr Cys Thr Gly Ala Ala Gly 
    50                  55                  60                  


Thr Gly Cys Ala Gly Cys Thr Thr Cys Thr Gly Cys Ala Gly Thr Cys 
65                  70                  75                  80  


Thr Gly Gly Thr Gly Gly Thr Gly Gly Thr Gly Thr Thr Gly Thr Gly 
                85                  90                  95      


Cys Ala Gly Cys Cys Thr Gly Gly Thr Gly Gly Cys Thr Cys Thr Cys 
            100                 105                 110         


Thr Gly Ala Gly Ala Cys Thr Gly Thr Cys Thr Thr Gly Thr Gly Ala 
        115                 120                 125             


Ala Gly Cys Cys Thr Cys Thr Gly Gly Cys Thr Thr Cys Ala Cys Cys 
    130                 135                 140                 


Thr Thr Cys Ala Gly Cys Ala Gly Cys Thr Ala Cys Ala Gly Cys Ala 
145                 150                 155                 160 


Thr Gly Cys Ala Cys Thr Gly Gly Gly Thr Thr Ala Gly Ala Cys Ala 
                165                 170                 175     


Gly Gly Cys Cys Cys Cys Thr Gly Gly Cys Ala Ala Ala Gly Gly Cys 
            180                 185                 190         


Cys Thr Gly Gly Ala Ala Thr Gly Gly Cys Thr Gly Ala Cys Cys Cys 
        195                 200                 205             


Thr Gly Ala Thr Cys Ala Gly Cys Thr Ala Cys Ala Ala Thr Gly Gly 
    210                 215                 220                 


Gly Gly Thr Cys Ala Ala Cys Ala Ala Gly Thr Ala Cys Thr Ala Thr 
225                 230                 235                 240 


Gly Cys Cys Ala Ala Gly Thr Cys Thr Gly Thr Gly Ala Ala Gly Gly 
                245                 250                 255     


Gly Cys Ala Gly Ala Thr Thr Thr Gly Cys Cys Ala Thr Cys Ala Gly 
            260                 265                 270         


Cys Ala Gly Ala Gly Ala Thr Gly Ala Cys Ala Gly Cys Ala Ala Gly 
        275                 280                 285             


Ala Gly Cys Ala Cys Cys Cys Thr Gly Thr Thr Thr Cys Thr Gly Cys 
    290                 295                 300                 


Ala Gly Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Ala Cys 
305                 310                 315                 320 


Cys Ala Cys Ala Gly Ala Thr Gly Ala Cys Ala Cys Ala Gly Cys Ala 
                325                 330                 335     


Gly Thr Gly Thr Ala Cys Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala 
            340                 345                 350         


Gly Ala Thr Gly Thr Cys Cys Cys Ala Thr Thr Cys Cys Thr Ala Gly 
        355                 360                 365             


Ala Gly Cys Thr Gly Cys Cys Ala Gly Cys Thr Ala Cys Ala Gly Ala 
    370                 375                 380                 


Ala Ala Thr Gly Gly Gly Gly Ala Cys Ala Ala Cys Thr Ala Cys Thr 
385                 390                 395                 400 


Thr Thr Gly Ala Gly Thr Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly 
                405                 410                 415     


Cys Ala Cys Ala Cys Thr Gly Gly Thr Cys Ala Cys Ala Gly Thr Gly 
            420                 425                 430         


Thr Cys Cys Thr Cys Thr Gly Cys Cys Thr Cys Thr Ala Cys Ala Ala 
        435                 440                 445             


Ala Gly Gly Gly Cys Cys Cys Cys Thr Cys Thr Gly Thr Gly Thr Thr 
    450                 455                 460                 


Thr Cys Cys Thr Cys Thr Gly Gly Cys Thr Cys Cys Thr Ala Gly Cys 
465                 470                 475                 480 


Ala Gly Cys Ala Ala Gly Thr Cys Cys Ala Cys Cys Ala Gly Thr Gly 
                485                 490                 495     


Gly Thr Gly Gly Thr Ala Cys Ala Gly Cys Thr Gly Cys Cys Cys Thr 
            500                 505                 510         


Gly Gly Gly Cys Thr Gly Thr Cys Thr Gly Gly Thr Cys Ala Ala Gly 
        515                 520                 525             


Gly Ala Thr Thr Ala Cys Thr Thr Cys Cys Cys Thr Gly Ala Gly Cys 
    530                 535                 540                 


Cys Thr Gly Thr Gly Ala Cys Thr Gly Thr Gly Thr Cys Cys Thr Gly 
545                 550                 555                 560 


Gly Ala Ala Thr Thr Cys Thr Gly Gly Gly Gly Cys Thr Cys Thr Gly 
                565                 570                 575     


Ala Cys Cys Thr Cys Thr Gly Gly Gly Gly Thr Gly Cys Ala Cys Ala 
            580                 585                 590         


Cys Cys Thr Thr Thr Cys Cys Ala Gly Cys Thr Gly Thr Gly Cys Thr 
        595                 600                 605             


Gly Cys Ala Gly Thr Cys Cys Thr Cys Thr Gly Gly Cys Cys Thr Gly 
    610                 615                 620                 


Thr Ala Cys Thr Cys Thr Cys Thr Gly Thr Cys Cys Thr Cys Thr Gly 
625                 630                 635                 640 


Thr Gly Gly Thr Thr Ala Cys Ala Gly Thr Gly Cys Cys Ala Ala Gly 
                645                 650                 655     


Cys Ala Gly Cys Thr Cys Thr Cys Thr Gly Gly Gly Cys Ala Cys Cys 
            660                 665                 670         


Cys Ala Gly Ala Cys Cys Thr Ala Cys Ala Thr Cys Thr Gly Cys Ala 
        675                 680                 685             


Ala Thr Gly Thr Gly Ala Ala Cys Cys Ala Cys Ala Ala Gly Cys Cys 
    690                 695                 700                 


Thr Ala Gly Cys Ala Ala Cys Ala Cys Cys Ala Ala Gly Gly Thr Gly 
705                 710                 715                 720 


Gly Ala Cys Ala Ala Gly Ala Gly Ala Gly Thr Gly Gly Ala Ala Cys 
                725                 730                 735     


Cys Cys Ala Ala Gly Ala Gly Cys Thr Gly Thr Gly Ala Cys Ala Ala 
            740                 745                 750         


Gly Ala Cys Cys Cys Ala Cys Ala Gly Ala Ala Ala Gly Ala Gly Ala 
        755                 760                 765             


Ala Gly Ala Gly Gly Cys Thr Cys Thr Gly Gly Ala Gly Ala Ala Gly 
    770                 775                 780                 


Gly Cys Ala Gly Ala Gly Gly Cys Ala Gly Cys Cys Thr Gly Cys Thr 
785                 790                 795                 800 


Gly Ala Cys Ala Thr Gly Thr Gly Gly Gly Gly Ala Thr Gly Thr Thr 
                805                 810                 815     


Gly Ala Ala Gly Ala Gly Ala Ala Thr Cys Cys Thr Gly Gly Gly Cys 
            820                 825                 830         


Cys Thr Ala Thr Gly Thr Ala Thr Ala Gly Ala Ala Thr Gly Cys Ala 
        835                 840                 845             


Ala Cys Thr Gly Cys Thr Cys Cys Thr Cys Cys Thr Gly Ala Thr Thr 
    850                 855                 860                 


Gly Cys Thr Cys Thr Gly Ala Gly Cys Cys Thr Gly Gly Cys Thr Cys 
865                 870                 875                 880 


Thr Gly Gly Thr Thr Ala Cys Cys Ala Ala Cys Ala Gly Cys Cys Ala 
                885                 890                 895     


Gly Gly Cys Thr Gly Thr Gly Gly Thr Cys Ala Cys Ala Cys Ala Ala 
            900                 905                 910         


Gly Ala Gly Cys Cys Cys Ala Gly Cys Cys Thr Gly Thr Cys Thr Gly 
        915                 920                 925             


Thr Gly Thr Cys Thr Cys Cys Thr Gly Gly Thr Gly Gly Ala Ala Cys 
    930                 935                 940                 


Ala Gly Thr Gly Ala Cys Cys Cys Thr Gly Ala Cys Thr Thr Gly Thr 
945                 950                 955                 960 


Gly Cys Cys Cys Thr Cys Thr Cys Thr Thr Cys Thr Gly Cys Cys Thr 
                965                 970                 975     


Cys Thr Gly Thr Gly Thr Cys Cys Ala Cys Ala Ala Gly Cys Ala Gly 
            980                 985                 990         


Cys Thr Ala Cys Cys Cys Cys Ala  Gly Cys Thr Gly Gly  Thr Ala Thr 
        995                 1000                 1005             


Cys Ala  Gly Cys Ala Gly Ala  Cys Ala Cys Cys Thr  Gly Gly Cys 
    1010                 1015                 1020             


Cys Ala  Gly Cys Cys Ala Cys  Cys Thr Ala Gly Ala  Ala Thr Gly 
    1025                 1030                 1035             


Cys Thr  Gly Ala Thr Cys Cys  Ala Cys Ala Ala Cys  Ala Cys Thr 
    1040                 1045                 1050             


Gly Ala  Cys Ala Cys Cys Ala  Gly Ala Ala Gly Cys  Thr Cys Thr 
    1055                 1060                 1065             


Gly Gly  Gly Gly Thr Cys Cys  Cys Ala Gly Ala Cys  Ala Gly Ala 
    1070                 1075                 1080             


Thr Thr  Cys Thr Cys Thr Gly  Gly Cys Ala Gly Cys  Ala Thr Cys 
    1085                 1090                 1095             


Cys Thr  Gly Gly Gly Ala Ala  Ala Gly Ala Ala Gly  Gly Cys Thr 
    1100                 1105                 1110             


Gly Cys  Cys Cys Thr Gly Ala  Cys Ala Ala Thr Cys  Ala Cys Thr 
    1115                 1120                 1125             


Gly Gly  Thr Gly Cys Cys Cys  Ala Gly Gly Cys Thr  Gly Ala Thr 
    1130                 1135                 1140             


Gly Ala  Thr Gly Ala Gly Thr  Cys Thr Gly Ala Cys  Thr Ala Cys 
    1145                 1150                 1155             


Thr Ala  Thr Thr Gly Thr Gly  Thr Gly Gly Thr Gly  Thr Ala Cys 
    1160                 1165                 1170             


Cys Thr  Thr Gly Gly Cys Ala  Ala Thr Gly Gly Cys  Thr Thr Thr 
    1175                 1180                 1185             


Thr Gly  Gly Gly Thr Gly Thr  Thr Cys Gly Gly Thr  Gly Gly Thr 
    1190                 1195                 1200             


Gly Gly  Cys Ala Cys Cys Ala  Ala Ala Cys Thr Gly  Ala Cys Thr 
    1205                 1210                 1215             


Gly Thr  Gly Cys Thr Gly Gly  Gly Ala Cys Ala Gly  Cys Cys Thr 
    1220                 1225                 1230             


Ala Ala  Ala Gly Cys Thr Gly  Cys Cys Cys Cys Thr  Thr Cys Thr 
    1235                 1240                 1245             


Gly Thr  Gly Ala Cys Ala Cys  Thr Gly Thr Thr Cys  Cys Cys Ala 
    1250                 1255                 1260             


Cys Cys  Thr Ala Gly Cys Thr  Cys Thr Gly Ala Gly  Gly Ala Ala 
    1265                 1270                 1275             


Cys Thr  Gly Cys Ala Gly Gly  Cys Cys Ala Ala Cys  Ala Ala Ala 
    1280                 1285                 1290             


Gly Cys  Cys Ala Cys Ala Cys  Thr Thr Gly Thr Gly  Thr Gly Cys 
    1295                 1300                 1305             


Cys Thr  Gly Ala Thr Cys Thr  Cys Thr Gly Ala Cys  Thr Thr Cys 
    1310                 1315                 1320             


Thr Ala  Cys Cys Cys Thr Gly  Gly Gly Gly Cys Thr  Gly Thr Gly 
    1325                 1330                 1335             


Ala Cys  Ala Gly Thr Gly Gly  Cys Thr Thr Gly Gly  Ala Ala Gly 
    1340                 1345                 1350             


Gly Cys  Thr Gly Ala Thr Ala  Gly Cys Ala Gly Cys  Cys Cys Thr 
    1355                 1360                 1365             


Gly Thr  Gly Ala Ala Gly Gly  Cys Thr Gly Gly Gly  Gly Thr Thr 
    1370                 1375                 1380             


Gly Ala  Gly Ala Cys Ala Ala  Cys Cys Ala Cys Ala  Cys Cys Thr 
    1385                 1390                 1395             


Ala Gly  Cys Ala Ala Gly Cys  Ala Gly Ala Gly Cys  Ala Ala Cys 
    1400                 1405                 1410             


Ala Ala  Cys Ala Ala Ala Thr  Ala Thr Gly Cys Thr  Gly Cys Cys 
    1415                 1420                 1425             


Thr Cys  Cys Ala Gly Cys Thr  Ala Thr Cys Thr Gly  Thr Cys Thr 
    1430                 1435                 1440             


Cys Thr  Gly Ala Cys Cys Cys  Cys Thr Gly Ala Gly  Cys Ala Gly 
    1445                 1450                 1455             


Thr Gly  Gly Ala Ala Gly Thr  Cys Cys Cys Ala Cys  Ala Gly Ala 
    1460                 1465                 1470             


Thr Cys  Cys Thr Ala Cys Ala  Gly Cys Thr Gly Thr  Cys Ala Ala 
    1475                 1480                 1485             


Gly Thr  Gly Ala Cys Cys Cys  Ala Thr Gly Ala Gly  Gly Gly Cys 
    1490                 1495                 1500             


Thr Cys  Cys Ala Cys Ala Gly  Thr Gly Gly Ala Ala  Ala Ala Gly 
    1505                 1510                 1515             


Ala Cys  Ala Gly Thr Gly Gly  Cys Cys Cys Cys Ala  Ala Cys Ala 
    1520                 1525                 1530             


Gly Ala  Gly Thr Gly Cys Ala  Gly Cys 
    1535                 1540         


<210>  392
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain with signal peptide

<400>  392

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Leu Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr 
65                  70                  75                  80  


Ala Lys Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys 
                85                  90                  95      


Ser Thr Leu Phe Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg 
        115                 120                 125             


Asn Gly Asp Asn Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250             


<210>  393
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain with no signal peptide

<400>  393

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230             


<210>  394
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain with signal peptide

<400>  394

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val 
            20                  25                  30          


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser 
        35                  40                  45              


Val Ser Thr Ser Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln 
    50                  55                  60                  


Pro Pro Arg Met Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr 
                85                  90                  95      


Ile Thr Gly Ala Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val 
            100                 105                 110         


Tyr Leu Gly Asn Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210>  395
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain with no signal peptide

<400>  395

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met 
        35                  40                  45              


Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn 
                85                  90                  95      


Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  396
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; eGFP coding sequence

<400>  396
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa      720


<210>  397
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; eGFP protein

<400>  397

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


