                         SEQUENCE LISTING

<110>  AAVANTIBIO, Inc.
 
<120>  METHODS AND COMPOSITIONS FOR TREATMENT OF FRIEDREICH'S ATAXIA

<130>  U1202.70078WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/133,624
<151>  2021-01-04

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  633
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  hFXN codon opt (w/ stop codon)

<400>  1
atgtggaccc tcggccgcag agctgttgct ggacttcttg cctctccatc tccagctcag       60

gcccagacac tgaccagagt gcctagacct gctgaactgg cccctctgtg tggcagaaga      120

ggcctgagaa ccgacatcga cgccacatgc acacctagaa gggccagcag caatcagcgg      180

ggcctgaatc agatctggaa cgtgaagaaa cagagcgtgt acctgatgaa cctgagaaag      240

agcggcaccc tgggacaccc tggaagcctg gatgagacaa cctacgagag actggccgag      300

gaaaccctgg attccctggc cgagttcttc gaggacctgg ccgataagcc ctacaccttc      360

gaggattacg acgtgtcctt tggcagcggc gtgctgacag tgaaactcgg cggagatctg      420

ggcacctacg tgatcaacaa gcagacccct aacaaacaga tctggctgag cagccctagc      480

agcggcccca agagatatga ttggaccggc aagaactggg tgtacagcca cgatggcgtg      540

tccctgcacg aactgctggc tgccgaactg acaaaggccc tgaaaacaaa gctggacctg      600

tccagcctgg cctactctgg caaggacgcc tga                                   633


<210>  2
<211>  630
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  hFXN codon optimized (no stop codon)

<400>  2
atgtggaccc tcggccgcag agctgttgct ggacttcttg cctctccatc tccagctcag       60

gcccagacac tgaccagagt gcctagacct gctgaactgg cccctctgtg tggcagaaga      120

ggcctgagaa ccgacatcga cgccacatgc acacctagaa gggccagcag caatcagcgg      180

ggcctgaatc agatctggaa cgtgaagaaa cagagcgtgt acctgatgaa cctgagaaag      240

agcggcaccc tgggacaccc tggaagcctg gatgagacaa cctacgagag actggccgag      300

gaaaccctgg attccctggc cgagttcttc gaggacctgg ccgataagcc ctacaccttc      360

gaggattacg acgtgtcctt tggcagcggc gtgctgacag tgaaactcgg cggagatctg      420

ggcacctacg tgatcaacaa gcagacccct aacaaacaga tctggctgag cagccctagc      480

agcggcccca agagatatga ttggaccggc aagaactggg tgtacagcca cgatggcgtg      540

tccctgcacg aactgctggc tgccgaactg acaaaggccc tgaaaacaaa gctggacctg      600

tccagcctgg cctactctgg caaggacgcc                                       630


<210>  3
<211>  210
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  hFXN codon optimized AA

<400>  3

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala 
    210 


<210>  4
<211>  367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  CMV enchancer of CBA

<400>  4
ccctagttat taatagtaat caattacggg gtcattagtt catagcccat atatggagtt       60

ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc      120

attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg      180

tcaatgggtg gactatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat      240

gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca      300

gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat      360

taccatg                                                                367


<210>  5
<211>  278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  chicken beta actin promoter

<400>  5
tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa       60

ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg      120

ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg cggagaggtg      180

cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc      240

ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcg                              278


<210>  6
<211>  1813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  3'-UTR

<400>  6
tcgagtgccc cagccccgtt ttaaggacat taaaagctat caggccaaga ccccagcttc       60

attatgcagc tgaggtctgt tttttgttgt tgttgttgtt tatttttttt attcctgctt      120

ttgaggacag ttgggctatg tgtcacagct ctgtagaaag aatgtgttgc ctcctacctt      180

gcccccaagt tctgattttt aatttctatg gaagattttt tggattgtcg gatttcctcc      240

ctcacatgat accccttatc ttttataatg tcttatgcct atacctgaat ataacaacct      300

ttaaaaaagc aaaataataa gaaggaaaaa ttccaggagg gaaaatgaat tgtcttcact      360

cttcattctt tgaaggattt actgcaagaa gtacatgaag agcagctggt caacctgctc      420

actgttctat ctccaaatga gacacattaa agggtagcct acaaatgttt tcaggcttct      480

ttcaaagtgt aagcacttct gagctcttta gcattgaagt gtcgaaagca actcacacgg      540

gaagatcatt tcttatttgt gctctgtgac tgccaaggtg tggcctgcac tgggttgtcc      600

agggagacat gcatctagtg ctgtttctcc cacatattca catacgtgtc tgtgtgtata      660

tatatttttt caatttaaag gttagtatgg aatcagctgc tacaagaatg caaaaaatct      720

tccaaagaca agaaaagagg aaaaaaagcc gttttcatga gctgagtgat gtagcgtaac      780

aaacaaaatc atggagctga ggaggtgcct tgtaaacatg aaggggcaga taaaggaagg      840

agatactcat gttgataaag agagccctgg tcctagacat agttcagcca caaagtagtt      900

gtccctttgt ggacaagttt cccaaattcc ctggacctct gcttccccat ctgttaaatg      960

agagaataga gtatggttga ttcccagcat tcagtggtcc tgtcaagcaa cctaacaggc     1020

tagttctaat tccctattgg gtagatgagg ggatgacaaa gaacagtttt taagctatat     1080

aggaaacatt gttattggtg ttgccctatc gtgatttcag ttgaattcat gtgaaaataa     1140

tagccatcct tggcctggcg cggtggctca cacctgtaat cccagcactt ttggaggcca     1200

aggtgggtgg atcacctgag gtcaggagtt caagaccagc ctggccaaca tgatgaaacc     1260

ccgtctctac taaaaataca aaaaattagc cgggcatgat ggcaggtgcc tgtaatccca     1320

gctacttggg aggctgaagc ggaagaatcg cttgaaccca gaggtggagg ttgcagtgag     1380

ccgagatcgt gccattgcac tgtaacctgg gtgactgagc aaaactctgt ctcaaaataa     1440

taataacaat ataataataa taatagccat cctttattgt acccttactg ggttaatcgt     1500

attataccac attacctcat tttaattttt actgacctgc actttataca aagcaacaag     1560

cctccaggac attaaaattc atgcaaagtt atgctcatgt tatattattt tcttacttaa     1620

agaaggattt attagtggct gggcatggtg gcgtgcacct gtaatcccag gtactcagga     1680

ggctgagacg ggagaattgc ttgaccccag gcggaggagg ttacagtgag tcgagatcgt     1740

acctgagcga cagagcgaga ctccgtctca aaaaaaaaaa aaaggagggt ttattaatga     1800

gaagtttggt cga                                                        1813


<210>  7
<211>  1019
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  chimeric intron

<400>  7
ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc       60

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      120

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      180

aagccttgag gggctccggg agggcccttt gtgcgggggg gagcggctcg gggggtgcgt      240

gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggcccgcg ctgcccggcg gctgtgagcg      300

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg      360

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt      420

gtgcgtgggg gggtgagcag ggggtgtggg cgcggcggtc gggctgtaac ccccccctgc      480

acccccctcc ccgagttgct gagcacggcc cggcttcggg tgcggggctc cgtacggggc      540

gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca ggtgggggtg ccgggcgggg      600

cggggccgcc tcgggccggg gagggctcgg gggaggggcg cggcggcccc cggagcgccg      660

gcggctgtcg aggcgcggcg agccgcagcc attgcctttt atggtaatcg tgcgagaggg      720

cgcagggact tcctttgtcc caaatctgtg cggagccgaa atctgggagg cgccgccgca      780

ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg caggaaggaa atgggcgggg      840

agggccttcg tgcgtcgccg cgccgccgtc cccttctccc tctccagcct cggggctgtc      900

cgcgggggga cggctgcctt cgggggggac ggggcagggc ggggttcggc ttctggcgtg      960

tgaccggcgg ctctagagcc tctgctaacc atgttcatgc cttcttcttt ttcctacag      1019


<210>  8
<211>  7637
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  B757_pTR_CBA_hFXNco_3'UTR plasmid

<400>  8
ctgcaggggg gggggggggg gggttggcca ctccctctct gcgcgctcgc tcgctcactg       60

aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg      120

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctag atctgaattc      180

ggtaccctag ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg      240

agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc      300

gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt      360

gacgtcaatg ggtggactat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc      420

atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg      480

cccagtacat gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg      540

ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc tcccccccct      600

ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg atgggggcgg      660

gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg ggcggggcga      720

ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt ccttttatgg      780

cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg ggagtcgctg      840

cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc gccccggctc      900

tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc tccgggctgt      960

aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga aagccttgag     1020

gggctccggg agggcccttt gtgcgggggg gagcggctcg gggggtgcgt gcgtgtgtgt     1080

gtgcgtgggg agcgccgcgt gcggcccgcg ctgcccggcg gctgtgagcg ctgcgggcgc     1140

ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg gggcggtgcc     1200

ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt gtgcgtgggg     1260

gggtgagcag ggggtgtggg cgcggcggtc gggctgtaac ccccccctgc acccccctcc     1320

ccgagttgct gagcacggcc cggcttcggg tgcggggctc cgtacggggc gtggcgcggg     1380

gctcgccgtg ccgggcgggg ggtggcggca ggtgggggtg ccgggcgggg cggggccgcc     1440

tcgggccggg gagggctcgg gggaggggcg cggcggcccc cggagcgccg gcggctgtcg     1500

aggcgcggcg agccgcagcc attgcctttt atggtaatcg tgcgagaggg cgcagggact     1560

tcctttgtcc caaatctgtg cggagccgaa atctgggagg cgccgccgca ccccctctag     1620

cgggcgcggg gcgaagcggt gcggcgccgg caggaaggaa atgggcgggg agggccttcg     1680

tgcgtcgccg cgccgccgtc cccttctccc tctccagcct cggggctgtc cgcgggggga     1740

cggctgcctt cgggggggac ggggcagggc ggggttcggc ttctggcgtg tgaccggcgg     1800

ctctagagcc tctgctaacc atgttcatgc cttcttcttt ttcctacagc tcctgggcaa     1860

cgtgctggtt attgtgctgt ctcatcattt tggcaaagaa ttcctcgaag atccgaaggg     1920

gttcaagctt aaaaactagt gccaccatgt ggaccctcgg ccgcagagct gttgctggac     1980

ttcttgcctc tccatctcca gctcaggccc agacactgac cagagtgcct agacctgctg     2040

aactggcccc tctgtgtggc agaagaggcc tgagaaccga catcgacgcc acatgcacac     2100

ctagaagggc cagcagcaat cagcggggcc tgaatcagat ctggaacgtg aagaaacaga     2160

gcgtgtacct gatgaacctg agaaagagcg gcaccctggg acaccctgga agcctggatg     2220

agacaaccta cgagagactg gccgaggaaa ccctggattc cctggccgag ttcttcgagg     2280

acctggccga taagccctac accttcgagg attacgacgt gtcctttggc agcggcgtgc     2340

tgacagtgaa actcggcgga gatctgggca cctacgtgat caacaagcag acccctaaca     2400

aacagatctg gctgagcagc cctagcagcg gccccaagag atatgattgg accggcaaga     2460

actgggtgta cagccacgat ggcgtgtccc tgcacgaact gctggctgcc gaactgacaa     2520

aggccctgaa aacaaagctg gacctgtcca gcctggccta ctctggcaag gacgcctgat     2580

gatgactcga gtgccccagc cccgttttaa ggacattaaa agctatcagg ccaagacccc     2640

agcttcatta tgcagctgag gtctgttttt tgttgttgtt gttgtttatt ttttttattc     2700

ctgcttttga ggacagttgg gctatgtgtc acagctctgt agaaagaatg tgttgcctcc     2760

taccttgccc ccaagttctg atttttaatt tctatggaag attttttgga ttgtcggatt     2820

tcctccctca catgataccc cttatctttt ataatgtctt atgcctatac ctgaatataa     2880

caacctttaa aaaagcaaaa taataagaag gaaaaattcc aggagggaaa atgaattgtc     2940

ttcactcttc attctttgaa ggatttactg caagaagtac atgaagagca gctggtcaac     3000

ctgctcactg ttctatctcc aaatgagaca cattaaaggg tagcctacaa atgttttcag     3060

gcttctttca aagtgtaagc acttctgagc tctttagcat tgaagtgtcg aaagcaactc     3120

acacgggaag atcatttctt atttgtgctc tgtgactgcc aaggtgtggc ctgcactggg     3180

ttgtccaggg agacatgcat ctagtgctgt ttctcccaca tattcacata cgtgtctgtg     3240

tgtatatata ttttttcaat ttaaaggtta gtatggaatc agctgctaca agaatgcaaa     3300

aaatcttcca aagacaagaa aagaggaaaa aaagccgttt tcatgagctg agtgatgtag     3360

cgtaacaaac aaaatcatgg agctgaggag gtgccttgta aacatgaagg ggcagataaa     3420

ggaaggagat actcatgttg ataaagagag ccctggtcct agacatagtt cagccacaaa     3480

gtagttgtcc ctttgtggac aagtttccca aattccctgg acctctgctt ccccatctgt     3540

taaatgagag aatagagtat ggttgattcc cagcattcag tggtcctgtc aagcaaccta     3600

acaggctagt tctaattccc tattgggtag atgaggggat gacaaagaac agtttttaag     3660

ctatatagga aacattgtta ttggtgttgc cctatcgtga tttcagttga attcatgtga     3720

aaataatagc catccttggc ctggcgcggt ggctcacacc tgtaatccca gcacttttgg     3780

aggccaaggt gggtggatca cctgaggtca ggagttcaag accagcctgg ccaacatgat     3840

gaaaccccgt ctctactaaa aatacaaaaa attagccggg catgatggca ggtgcctgta     3900

atcccagcta cttgggaggc tgaagcggaa gaatcgcttg aacccagagg tggaggttgc     3960

agtgagccga gatcgtgcca ttgcactgta acctgggtga ctgagcaaaa ctctgtctca     4020

aaataataat aacaatataa taataataat agccatcctt tattgtaccc ttactgggtt     4080

aatcgtatta taccacatta cctcatttta atttttactg acctgcactt tatacaaagc     4140

aacaagcctc caggacatta aaattcatgc aaagttatgc tcatgttata ttattttctt     4200

acttaaagaa ggatttatta gtggctgggc atggtggcgt gcacctgtaa tcccaggtac     4260

tcaggaggct gagacgggag aattgcttga ccccaggcgg aggaggttac agtgagtcga     4320

gatcgtacct gagcgacaga gcgagactcc gtctcaaaaa aaaaaaaaag gagggtttat     4380

taatgagaag tttggtcgac tagagctcgc tgatcagcct cgactgtgcc ttctagttgc     4440

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     4500

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     4560

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     4620

catgctgggg agagatctag gaacccctag tgatggagtt ggccactccc tctctgcgcg     4680

ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc     4740

cggcctcagt gagcgagcga gcgcgcagag agggagtggc caaccccccc cccccccccc     4800

ctgcagccca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg     4860

ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag     4920

cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag     4980

gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc     5040

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc     5100

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc     5160

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt     5220

cgggaagcgt ggcgctttct caatgctcac gctgtaggta tctcagttcg gtgtaggtcg     5280

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat     5340

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag     5400

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt     5460

ggtggcctaa ctacggctac actagaagga cagtatttgg tatctgcgct ctgctgaagc     5520

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta     5580

gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag     5640

atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga     5700

ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa     5760

gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa     5820

tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc     5880

ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga     5940

taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa     6000

gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt     6060

gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg     6120

ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc     6180

aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg     6240

gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag     6300

cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt     6360

actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt     6420

caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac     6480

gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac     6540

ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag     6600

caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa     6660

tactcatact cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga     6720

gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc     6780

cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta acctataaaa     6840

ataggcgtat cacgaggccc tttcgtctcg cgcgtttcgg tgatgacggt gaaaacctct     6900

gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc gggagcagac     6960

aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggctggctt aactatgcgg     7020

catcagagca gattgtactg agagtgcacc atatgcggtg tgaaataccg cacagatgcg     7080

taaggagaaa ataccgcatc aggaaattgt aaacgttaat attttgttaa aattcgcgtt     7140

aaatttttgt taaatcagct cattttttaa ccaataggcc gaaatcggca aaatccctta     7200

taaatcaaaa gaatagaccg agatagggtt gagtgttgtt ccagtttgga acaagagtcc     7260

actattaaag aacgtggact ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg     7320

cccactacgt gaaccatcac cctaatcaag ttttttgggg tcgaggtgcc gtaaagcact     7380

aaatcggaac cctaaaggga gcccccgatt tagagcttga cggggaaagc cggcgaacgt     7440

ggcgagaaag gaagggaaga aagcgaaagg agcgggcgct agggcgctgg caagtgtagc     7500

ggtcacgctg cgcgtaacca ccacacccgc cgcgcttaat gcgccgctac agggcgcgtc     7560

gcgccattcg ccattcaggc tacgcaactg ttgggaaggg cgatcggtgc gggcctcttc     7620

gctattacgc cagctgg                                                    7637


<210>  9
<211>  712
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Desmin promoter

<400>  9
gatcttaccc cctgcccccc acagctcctc tcctgtgcct tgtttcccag ccatgcgttc       60

tcctctataa atacccgctc tggtatttgg ggttggcagc tgttgctgcc agggagatgg      120

ttgggttgac atgcggctcc tgacaaaaca caaacccctg gtgtgtgtgg gcgtgggtgg      180

tgtgagtagg gggatgaatc agggaggggg cgggggaccc agggggcagg agccacacaa      240

agtctgtgcg ggggtgggag cgcacatagc aattggaaac tgaaagctta tcagaccctt      300

tctggaaatc agcccactgt ttataaactt gaggccccac cctcgagata accagggctg      360

aaagaggccc gcctgggggc tggagacatg cttgctgcct gccctggcga aggattggca      420

ggcttgcccg tcacaggacc cccgctggct gactcagggg cgcaggcctc ttgcggggga      480

gctggcctcc ccgcccccac ggccacgggc cgccctttcc tggcaggaca gcgggatctt      540

gcagctgtca ggggagggga ggcgggggct gatgtcagga gggatacaaa tagtgccgac      600

ggctgggggc cctgtctccc ctcgccgcat ccactctccg gccggccgcc tgtccgccgc      660

ctcctccgtg cgcccgccag cctcgcccgc gccgtcaccg tgaggcactg gg              712


<210>  10
<211>  1220
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human frataxin promoter

<400>  10
aagaaaactt tcacaatttg catccctttg taatatgtaa cagaaataaa attctctttt       60

aaaatctatc aacaataggc aaggcacggt ggctcacgcc tgtcgtctca gcactttgtg      120

aggcccaggc gggcagatcg tttgagccta gaagttcaag accaccctgg gcaacatagc      180

gaaaccccct ttctacaaaa aatacaaaaa ctagctgggt gtggtggtgc acacctgtag      240

tcccagctac ttggaaggct gaaatgggaa gactgcttga gcccgggagg gagaagttgc      300

agtaagccag gaccacacca ctgcactcca gcctgggcaa cagagtgaga ctctgtctca      360

aacaaacaaa taaatgaggc gggtggatca cgaggtcagt agatcgagac catcctggct      420

aacacggtga aacccgtctc tactaaaaaa aaaaaaaaat acaaaaaatt agccaggcat      480

ggtggcgggc gcctgtagtc ccagttactc gggaggctga ggcaggagaa tggcgtgaaa      540

ccgggaggca gagcttgcag tgagccgaga tcgcaccact gccctccagc ctgggcgaca      600

gagcgagact ccgtctcaat caatcaatca atcaataaaa tctattaaca atatttattg      660

tgcacttaac aggaacatgc cctgtccaaa aaaaacttta cagggcttaa ctcattttat      720

ccttaccaca atcctatgaa gtaggaactt ttataaaacg cattttataa acaaggcaca      780

gagaggttaa ttaacttgcc ctctggtcac acagctagga agtgggcaga gtacagattt      840

acacaaggca tccgtctcct ggccccacat acccaactgc tgtaaaccca taccggcggc      900

caagcagcct caatttgtgc atgcacccac ttcccagcaa gacagcagct cccaagttcc      960

tcctgtttag aattttagaa gcggcgggcc accaggctgc agtctccctt gggtcagggg     1020

tcctggttgc actccgtgct ttgcacaaag caggctctcc atttttgtta aatgcacgaa     1080

tagtgctaag ctgggaagtt cttcctgagg tctaacctct agctgctccc ccacagaaga     1140

gtgcctgcgg ccagtggcca ccaggggtcg ccgcagcacc cagcgctgga gggcggagcg     1200

ggcggcagac ccggagcagc                                                 1220


<210>  11
<211>  630
<212>  DNA
<213>  Homo sapiens

<400>  11
atgtggacac tggggagaag ggccgtggct ggactgctgg cttctccatc tccagcccag       60

gcccagaccc tgaccagagt gcctagacct gccgaactgg cccctctgtg tggcagaaga      120

ggcctgagaa ccgacatcga cgccacctgt acccccagaa gggccagcag caatcagcgg      180

ggcctgaatc agatctggaa cgtgaagaaa cagagcgtgt acctgatgaa cctgagaaag      240

agcggcaccc tgggccaccc tggaagcctg gatgagacaa cctacgagcg gctggccgag      300

gaaaccctgg attccctggc cgagttcttc gaggacctgg ccgacaagcc ctacaccttc      360

gaggattacg acgtgtcctt cggcagcggc gtgctgacag tgaagctggg cggagatctg      420

ggcacctacg tgatcaacaa gcagaccccc aacaaacaga tctggctgag cagccccagc      480

agcggcccca agagatacga ttggaccggc aagaactggg tgttcagcca cgacggcgtg      540

tccctgcatg agctgctggc tgccgagctg accaaggccc tgaaaacaaa gctggacctg      600

agctggctgg cctacagcgg caaagatgcc                                       630


<210>  12
<211>  1490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
aagaaggaaa aattccagga gggaaaatga attgtcttca ctcttcattc tttgaaggat       60

ttactgcaag aagtacatga agagcagctg gtcaacctgc tcactgttct atctccaaat      120

gagacacatt aaagggtagc ctacaaatgt tttcaggctt ctttcaaagt gtaagcactt      180

ctgagctctt tagcattgaa gtgtcgaaag caactcacac gggaagatca tttcttattt      240

gtgctctgtg actgccaagg tgtggcctgc actgggttgt ccagggagac atgcatctag      300

tgctgtttct cccacatatt cacatacgtg tctgtgtgta tatatatttt ttcaatttaa      360

aggttagtat ggaatcagct gctacaagaa tgcaaaaaat cttccaaaga caagaaaaga      420

ggaaaaaaag ccgttttcat gagctgagtg atgtagcgta acaaacaaaa tcatggagct      480

gaggaggtgc cttgtaaaca tgaaggggca gataaaggaa ggagatactc atgttgataa      540

agagagccct ggtcctagac atagttcagc cacaaagtag ttgtcccttt gtggacaagt      600

ttcccaaatt ccctggacct ctgcttcccc atctgttaaa tgagagaata gagtatggtt      660

gattcccagc attcagtggt cctgtcaagc aacctaacag gctagttcta attccctatt      720

gggtagatga ggggatgaca aagaacagtt tttaagctat ataggaaaca ttgttattgg      780

tgttgcccta tcgtgatttc agttgaattc atgtgaaaat aatagccatc cttggcctgg      840

cgcggtggct cacacctgta atcccagcac ttttggaggc caaggtgggt ggatcacctg      900

aggtcaggag ttcaagacca gcctggccaa catgatgaaa ccccgtctct actaaaaata      960

caaaaaatta gccgggcatg atggcaggtg cctgtaatcc cagctacttg ggaggctgaa     1020

gcggaagaat cgcttgaacc cagaggtgga ggttgcagtg agccgagatc gtgccattgc     1080

actgtaacct gggtgactga gcaaaactct gtctcaaaat aataataaca atataataat     1140

aataatagcc atcctttatt gtacccttac tgggttaatc gtattatacc acattacctc     1200

attttaattt ttactgacct gcactttata caaagcaaca agcctccagg acattaaaat     1260

tcatgcaaag ttatgctcat gttatattat tttcttactt aaagaaggat ttattagtgg     1320

ctgggcatgg tggcgtgcac ctgtaatccc aggtactcag gaggctgaga cgggagaatt     1380

gcttgacccc aggcggagga ggttacagtg agtcgagatc gtacctgagc gacagagcga     1440

gactccgtct caaaaaaaaa aaaaaggagg gtttattaat gagaagtttg                1490


