                         б

<110>  ҩƷ޹˾
 
<120>  PD-L1/CD47ȻṹԴʽ˫쿹弰Ʊ

<130>  LZ2118355CN07

<160>  48    

<170>  PatentIn version 3.3

<210>  1
<211>  321
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  1
gacatccaga tgacccagtc cccttcctcc ctgtccgcct ctgtgggcga cagggtgacc     60

atcacctgca aggcctccca ggatgtgcac accgccgtgg cttggattca gcagaagccc    120

ggcaagtccc ccaagctgct gatctactcc gcctccaacc ggtacaccgg cgtgcctagc    180

aggttcagcg gaagcggcag cggcaccgac ttcaccttca ccatctcctc cctgcagcct    240

gaggacatcg ccacctatta ctgccagcag cactacatca cccccctgac cttcggccag    300

ggcaccaagc tggagatcaa g                                              321


<210>  2
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val His Thr Ala 
            20                  25                  30          


Val Ala Trp Ile Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  321
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  3
cgtacggtgg ccgcccccag cgtcttcatt tttccaccct ctgacgaaca gctgaagtca     60

gggacagctt ccgtggtctg tctgctgaac aatttttacc ccagggaggc caaagtgcag    120

tggaaggtcg ataacgctct gcagagcgga aattctcagg agagtgtgac agaacaggac    180

tcaaaagatt ccacttatag cctgtctagt accctgacac tgtccaaggc agactacgaa    240

aagcataaag tgtatgcctg tgaggtcaca catcagggtc tgtcaagccc cgtcactaag    300

tccttcaacc ggggagaatg c                                              321


<210>  4
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  4

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  5
<211>  351
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  5
gaagtgcagc tggtgcagtc cggcgccgag gtgaagaagc ctggctcctc cgtgaaggtg     60

tcctgcaagg cctccggctt caacatcgag gacacctaca tccactgggt gaggcaggct    120

cccggacagg gactggagtg gatgggcagg atcgatcccg ccaacgccaa caccaagtac    180

gaccccaagt tccagggcag ggtgaccatc accgccgata ccagcaccaa caccgcctac    240

atggagctgt cctccctgag gtccgaggac acagccgtgt actactgtgg caggggactg    300

ggcgcctggt ttgcctactg gggacagggc accctggtga ccgtgtcctc c             351


<210>  6
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  6

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Glu Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Ala Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Leu Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  7
<211>  990
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  7
gctagcacaa aaggaccttc cgtgtttcca ctggcaccct ctagtaagag tacttcagga     60

ggaaccgcag cactgggatg tctggtgaag gactacttcc cagagcccgt caccgtgtct    120

tggaacagtg gagcactgac ctccggggtc catacatttc ctgccgtgct gcagtcatcc    180

ggtctgtata gcctgagctc tgtggtcaca gtcccaagtt catccctggg cacccagaca    240

tacatctgca acgtgaatca caaaccttcc aatactaagg tcgacaagaa agtggaaccc    300

aagtcctgcg ataagaccca cacatgccct ccctgtcctg ctcccgaact gctgggagga    360

ccctccgtct tcctgttccc ccccaagccc aaagacacac tgatgatcag caggacccct    420

gaagtgacct gcgtggtcgt ggacgtgagc cacgaggacc ccgaggtcaa gtttaactgg    480

tacgtggacg gcgtggaggt ccacaacgcc aagaccaagc ccagggagga gcagtacaac    540

agcacctaca gggtcgtgtc cgtgctgacc gtgctccacc aagattggct caacggcaag    600

gagtataagt gcaaagtcag caacaaggcc ctccccgccc ccatcgagaa aaccatcagc    660

aaggccaagg gccaaccgcg ggaacctcaa gtgtataccc tccctcccag ccgggatgag    720

ctgaccaaga accaagtctc cctcttgtgc ctggtcaagg gattctaccc ttccgacatt    780

gccgtcgaat gggagagcaa tggccagccc gagaacaact acaagacaac cccccccgtc    840

ctgcgcagcg acggatcctt cttcctgtac tccaagctca ccgtggacaa gagccggtgg    900

caacagggca acgtgttctc ctgtagcgtg atgcacgaag ccctccacaa ccactatacc    960

cagaagagcc tgagcctcag ccccggcaaa                                     990


<210>  8
<211>  330
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  8

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Arg Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  9
<211>  996
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  9
gctagcacaa aaggaccttc cgtgtttcca ctggcaccct ctagtaagag tacttcagga     60

ggaaccgcag cactgggatg tctggtgaag gactacttcc cagagcccgt caccgtgtct    120

tggaacagtg gagcactgac ctccggggtc catacatttc ctgccgtgct gcagtcatcc    180

ggtctgtata gcctgagctc tgtggtcaca gtcccaagtt catccctggg cacccagaca    240

tacatctgca acgtgaatca caaaccttcc aatactaagg tcgacaagaa agtggaaccc    300

aagtcctgcg ataagaccca cacatgccct ccctgtcctg ctcccgaact gctgggagga    360

ccctccgtct tcctgttccc ccccaagccc aaagacacac tgatgatcag caggacccct    420

gaagtgacct gcgtggtcgt ggacgtgagc cacgaggacc ccgaggtcaa gtttaactgg    480

tacgtggacg gcgtggaggt ccacaacgcc aagaccaagc ccagggagga gcagtacgcc    540

agcacctaca gggtcgtgtc cgtgctgacc gtgctccacc aagattggct caacggcaag    600

gagtataagt gcaaagtcag caacaaggcc ctccccgccc ccatcgagaa aaccatcagc    660

aaggccaagg gccaaccgcg ggaacctcaa gtgtataccc tccctcccag ccgggatgag    720

ctgaccaaga accaagtctc cctcttgtgc ctggtcaagg gattctaccc ttccgacatt    780

gccgtcgaat gggagagcaa tggccagccc gagaacaact acaagacaac cccccccgtc    840

ctgcgcagcg acggatcctt cttcctgtac tccaagctca ccgtggacaa gagccggtgg    900

caacagggca acgtgttctc ctgtagcgtg atgcacgaag ccctccacaa ccactatacc    960

cagaagagcc tgagcctcag ccccggcaaa tgatga                              996


<210>  10
<211>  330
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  10

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Arg Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  11
<211>  321
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  11
gacatcgtga tgacccagtc ccagaagttc atgtccacct ccgtgggcga ccgggtgagc     60

atcacttgta aggcctccca gaacgtgagg acctccatcg cttggtatca acagaagtcc    120

ggccagtccc ccaagacttt aatctattta gccagcaatc gtcacactgg tgtgcccgat    180

cgtttcactg gttctggctc cggcaccgac ttcactttaa ccatctccaa cgtgcagagc    240

gaggatttag ccgactactt ctgtttacag cactggaact accccttcac cttcggctct    300

ggcaccaagc tggagatcaa g                                              321


<210>  12
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  12

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ser 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  13
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  13
gaggtgcagc tgcaacagtc cggcgccgag ctggtgaaac ccggtgcctc cgtgaagctg     60

agctgcaccg cctccggctt caacatcgag gacatctaca tgcactgggt gaagcagagg    120

cccgaacaag gtttagagtg gatcggtcgt atcgaccccg ctaacgacaa caccaagtat    180

ggccccaagc tgcaaggtcg tgccaccatc accgctgaca cctcctccaa caccgcttat    240

ttacagctgt ccggtttaac ctccgaggac accggagtgt actactgcgt gcggcgtatt    300

cctaccgata tcatggacta ctggggaccc ggaacctccg tgaccgtgtc ctcc          354


<210>  14
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  14

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Glu Asp Ile 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Lys Tyr Gly Pro Lys Leu 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Arg Ile Pro Thr Asp Ile Met Asp Tyr Trp Gly Pro Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  15
<211>  990
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  15
gctagcacaa aaggaccttc cgtgtttcca ctggcaccct ctagtaagag tacttcagga     60

ggaaccgcag cactgggatg tctggtgaag gactacttcc cagagcccgt caccgtgtct    120

tggaacagtg gagcactgac ctccggggtc catacatttc ctgccgtgct gcagtcatcc    180

ggtctgtata gcctgagctc tgtggtcaca gtcccaagtt catccctggg cacccagaca    240

tacatctgca acgtgaatca caaaccttcc aatactaagg tcgacaagaa agtggaaccc    300

aagtcctgcg ataagaccca cacatgccct ccctgtcctg ctcccgaact gctgggagga    360

ccctccgtct tcctgttccc ccccaagccc aaagacacac tgatgatcag caggacccct    420

gaagtgacct gcgtggtcgt ggacgtgagc cacgaggacc ccgaggtcaa gtttaactgg    480

tacgtggacg gcgtggaggt ccacaacgcc aagaccaagc ccagggagga gcagtacgcc    540

agcacctaca gggtggtcag cgtgctgacc gtgctgcacc aggattggct caacggcaag    600

gagtacaagt gcaaagtctc caacaaggcc ctgcccgccc ccatcgagaa gaccatctcc    660

aaggctaagg gacagcccag ggagccccaa gtgtacaccg agcctcccag ccgggatgag    720

ctgaccaaga accaagtctc cctcacctgc ctggtcaagg gattctaccc ttccgacatt    780

gccgtcgaat gggagagcaa tggccagccc gagaacaact acaagacaac cccccccgtc    840

ctggatagcg acggatcctt cttcctgctc tccgtgctca ccgtcgacaa gagcagatgg    900

cagcagggca acgtgttcag ctgtagcgtg atgcacgagg ccctgcacaa ccactacacc    960

cagaagagcc tgtccctcag ccccggcaag                                     990


<210>  16
<211>  330
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  16

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Glu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Leu Ser Val Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  17
<211>  321
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  17
gacatcgtga tgacccagtc ccagaagttc atgtccacct ccgtgggcga ccgggtgagc     60

atcacttgta aggcctccca gaacgtgagg acctccatcg cttggtatca acagaagcct    120

ggccagtccc ccaagacttt aatctattta gccagcaatc gtcacactgg tgtgcccgat    180

cgtttcactg gttctggctc cggcaccgac ttcactttaa ccatctccaa cgtgcagagc    240

gaggatttag ccgactactt ctgtttacag cactggaact accccttcac cttcggctct    300

ggcaccaagc tggagatcaa g                                              321


<210>  18
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  18

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ser 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  19
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  19
gaggtgcagc tgcagcagag cggcgctgaa ctggtgaagc ccggtgccag cgtgaagctg     60

tcttgtaccg cctccggctt caacatcgag gacatctaca tgcactgggt gaagcagcgg    120

cccgaacaag gtttagagtg gatcggtcgt atcgaccccg ccaacgacaa caccaagtac    180

ggccccaagt tccaaggtcg tgccacaatg accgccgaca cctcctccaa caccgcctat    240

ctgcagctgt ccggtttaac aagcgaggac accggcgtgt actactgcgt gaggaggatc    300

accaccgacg tgatggacta ctggggacaa ggcacttccg tgaccgtgag ctcc          354


<210>  20
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  20

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Glu Asp Ile 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Lys Tyr Gly Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Arg Ile Thr Thr Asp Val Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  21
<211>  321
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  21
gacatccaga tgacccagtc ccctagctct ttatccgctt ccgtgggcga tcgtgtgacc     60

atcacttgta aggcctccca gaatgtgagg accagcatcg cttggtatca acagaagccc    120

ggcaaggccc ccaagcgttt aatctattta gcctccaata ggcacaccgg cgtgccttct    180

cgttttagcg gctccggctc cggcacagag ttcactttaa ccatctccaa tttacagccc    240

gaggacttcg ccacctacta ctgtttacag cactggaact accccttcac cttcggccaa    300

ggcactaagc tggagatcaa g                                              321


<210>  22
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ser 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  23
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  23
caagttcagc tggtgcagag cggagccgag gtgaagaagc ccggctcctc cgtgaaggtg     60

tcttgtaagg cctccggctt caacatcgag gacatctaca tgcactgggt gaggcaagct    120

cccggtcaag gtctggagtg gatgggtcgt atcgaccccg ccaacgacaa caccaagtac    180

ggccctaagc tgcaaggtcg ggtgaccatc acggccgatg agtccaccaa caccgcctac    240

atggagctgt cctctttacg gagcgaggat accgccgtgt actactgcgc gcggcgtatt    300

cctaccgaca tcatggacta ctggggccaa ggtacaaccg tgaccgtgtc ctcc          354


<210>  24
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Glu Asp Ile 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Lys Tyr Gly Pro Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ile Pro Thr Asp Ile Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  25
<211>  321
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  25
gacatccaga tgacccagtc ccctagctct ttatccgctt ccgtgggcga tcgtgtgacc     60

atcacttgta aggcctccca gaatgtgagg accagcatcg cttggtatca acagaagccc    120

ggcaaggccc ccaagcgttt aatctattta gcctccaata ggcacaccgg cgtgccttct    180

cgttttagcg gctccggctc cggcacagag ttcactttaa ccatctccaa tttacagccc    240

gaggacttcg ccacctacta ctgtttacag cactggaact accccttcac cttcggccaa    300

ggcactaagc tggagatcaa g                                              321


<210>  26
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ser 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  27
caagttcagc tggtgcagag cggagccgag gtgaagaagc ccggctcctc cgtgaaggtg     60

tcttgtaagg cctccggctt caacatcgag gacatctaca tgcactgggt gaggcaagct    120

cccggtcaag gtctggagtg gatgggtcgt atcgaccccg ccaacgacaa caccaagtac    180

ggccctaagc tgcaaggtcg ggtgaccatc acggccgata cctccaccag caccgcctac    240

atggagctgt cctctttacg gagcgaggat accgccgtgt actactgcgt gcggcgtatt    300

cctaccgaca tcatggacta ctggggccaa ggtacaaccg tgaccgtgtc ctcc          354


<210>  28
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Glu Asp Ile 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Lys Tyr Gly Pro Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Arg Ile Pro Thr Asp Ile Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  29
<211>  321
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  29
gacatccaga tgacccagtc ccctagctct ttatccgctt ccgtgggcga tcgtgtgacc     60

atcacttgta aggcctccca gaatgtgagg accagcatcg cttggtatca acagaagccc    120

ggcaaggccc ccaagacttt aatctattta gcctccaata ggcacaccgg cgtgccttct    180

cgttttagcg gctccggctc cggcacagag ttcactttaa ccatctccaa tttacagccc    240

gaggacttcg ccacctacta ctgtttacag cactggaact accccttcac cttcggccaa    300

ggcactaagc tggagatcaa g                                              321


<210>  30
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ser 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  31
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  31
caagttcagc tggtgcagag cggagccgag gtgaagaagc ccggctcctc cgtgaaggtg     60

tcttgtaagg cctccggctt caacatcgag gacatctaca tgcactgggt gaggcaagct    120

cccggtcaag gtctggagtg gatgggtcgt atcgaccccg ccaacgacaa caccaagtac    180

ggccctaagc tgcaaggtcg ggtgaccatc acggccgatg agtccaccag caccgcctac    240

atggagctgt cctctttacg gagcgaggat accgccgtgt actactgcgt gcggcgtatt    300

cctaccgaca tcatggacta ctggggccaa ggtacaaccg tgaccgtgtc ctcc          354


<210>  32
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Glu Asp Ile 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Lys Tyr Gly Pro Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Arg Ile Pro Thr Asp Ile Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  33
<211>  321
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  33
gacatccaga tgacccagtc ccctagctct ttatccgctt ccgtgggcga tcgtgtgacc     60

atcacttgta aggcctccca gaatgtgagg accagcatcg cttggtatca acagaagccc    120

ggcaaggccc ccaagacttt aatctattta gcctccaata ggcacaccgg cgtgccttct    180

cgttttagcg gctccggctc cggcacagag ttcactttaa ccatctccaa tttacagccc    240

gaggacttcg ccacctacta ctgtttacag cactggaact accccttcac cttcggccaa    300

ggcactaagc tggagatcaa g                                              321


<210>  34
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ser 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  35
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  35
caagttcagc tggtgcagag cggagccgag gtgaagaagc ccggctcctc cgtgaaggtg     60

tcttgtaagg cctccggctt caacatcgag gacatctaca tgcactgggt gaggcaagct    120

cccggtcaag gtctggagtg gatgggtcgt atcgaccccg ccaacgacaa caccaagtac    180

ggccctaagc tgcaaggtcg ggtgaccatc acggccgata cctccaccaa caccgcctac    240

atggagctgt cctctttacg gagcgaggat accgccgtgt actactgcgt gcggcgtatt    300

cctaccgaca tcatggacta ctggggccaa ggtacaaccg tgaccgtgtc ctcc          354


<210>  36
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱ

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Glu Asp Ile 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Lys Tyr Gly Pro Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Arg Ile Pro Thr Asp Ile Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             




<210>  37
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PDL1 HCDR1

<400>  37

Gly Phe Asn Ile Glu Asp Thr Tyr Ile His 
1               5                   10  


<210>  38
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PDL1 HCDR2

<400>  38

Arg Ile Asp Pro Ala Asn Ala Asn Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PDL1 HCDR3

<400>  39

Gly Leu Gly Ala Trp Phe Ala Tyr 
1               5               


<210>  40
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PDL1 LCDR1

<400>  40

Lys Ala Ser Gln Asp Val His Thr Ala Val Ala 
1               5                   10      


<210>  41
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PDL1 LCDR2

<400>  41

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PDL1 LCDR3

<400>  42

Gln Gln His Tyr Ile Thr Pro Leu Thr 
1               5                   


<210>  43
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD47 HCDR1

<400>  43

Gly Phe Asn Ile Glu Asp Ile Tyr Met His 
1               5                   10  


<210>  44
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD47 HCDR2

<400>  44

Arg Ile Asp Pro Ala Asn Asp Asn Thr Lys Tyr Gly Pro Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD47 HCDR3

<400>  45

Arg Ile Pro Thr Asp Ile Met Asp Tyr 
1               5                   


<210>  46
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD47 LCDR1

<400>  46

Lys Ala Ser Gln Asn Val Arg Thr Ser Ile Ala 
1               5                   10      


<210>  47
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD47 LCDR2

<400>  47

Leu Ala Ser Asn Arg His Thr 
1               5           


<210>  48
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD47 LCDR3

<400>  48

Leu Gln His Trp Asn Tyr Pro Phe Thr 
1               5                   
