                         SEQUENCE LISTING

<110>  University of Connecticut
 
<120>  USE OF FIBROBLAST GROWTH FACTOR-8 FOR TISSUE REGENERATION

<130>  21-0001-WO

<150>  63/134062
<151>  2021-01-05

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  233
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  1

Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Glu Gly Pro Gly Arg Gly Pro Ala Leu 
            20                  25                  30          


Gly Arg Glu Leu Ala Ser Leu Phe Arg Ala Gly Arg Glu Pro Gln Gly 
        35                  40                  45              


Val Ser Gln Gln His Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu 
    50                  55                  60                  


Ser Arg Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly 
65                  70                  75                  80  


Lys His Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu 
                85                  90                  95      


Asp Gly Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly 
            100                 105                 110         


Ser Arg Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met 
        115                 120                 125             


Asn Lys Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp 
    130                 135                 140                 


Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln 
145                 150                 155                 160 


Asn Ala Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg 
                165                 170                 175     


Pro Arg Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu Val His Phe 
            180                 185                 190         


Met Lys Arg Leu Pro Arg Gly His His Thr Thr Glu Gln Ser Leu Arg 
        195                 200                 205             


Phe Glu Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser 
    210                 215                 220                 


Gln Arg Thr Trp Ala Pro Glu Pro Arg 
225                 230             


<210>  2
<211>  204
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  2

Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln His Val Arg Glu Gln Ser Leu Val Thr 
            20                  25                  30          


Asp Gln Leu Ser Arg Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg 
        35                  40                  45              


Thr Ser Gly Lys His Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala 
    50                  55                  60                  


Met Ala Glu Asp Gly Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp 
65                  70                  75                  80  


Thr Phe Gly Ser Arg Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr 
                85                  90                  95      


Ile Cys Met Asn Lys Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys 
            100                 105                 110         


Gly Lys Asp Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr 
        115                 120                 125             


Ala Leu Gln Asn Ala Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg 
    130                 135                 140                 


Lys Gly Arg Pro Arg Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu 
145                 150                 155                 160 


Val His Phe Met Lys Arg Leu Pro Arg Gly His His Thr Thr Glu Gln 
                165                 170                 175     


Ser Leu Arg Phe Glu Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu 
            180                 185                 190         


Arg Gly Ser Gln Arg Thr Trp Ala Pro Glu Pro Arg 
        195                 200                 


<210>  3
<211>  215
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  3

Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Val Thr Val Gln Ser Ser Pro Asn Phe 
            20                  25                  30          


Thr Gln His Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu Ser Arg 
        35                  40                  45              


Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His 
    50                  55                  60                  


Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu Asp Gly 
65                  70                  75                  80  


Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      


Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys 
            100                 105                 110         


Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp Cys Val 
        115                 120                 125             


Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln Asn Ala 
    130                 135                 140                 


Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg Pro Arg 
145                 150                 155                 160 


Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys 
                165                 170                 175     


Arg Leu Pro Arg Gly His His Thr Thr Glu Gln Ser Leu Arg Phe Glu 
            180                 185                 190         


Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser Gln Arg 
        195                 200                 205             


Thr Trp Ala Pro Glu Pro Arg 
    210                 215 


<210>  4
<211>  244
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  4

Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Glu Gly Pro Gly Arg Gly Pro Ala Leu 
            20                  25                  30          


Gly Arg Glu Leu Ala Ser Leu Phe Arg Ala Gly Arg Glu Pro Gln Gly 
        35                  40                  45              


Val Ser Gln Gln Val Thr Val Gln Ser Ser Pro Asn Phe Thr Gln His 
    50                  55                  60                  


Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu Ser Arg Arg Leu Ile 
65                  70                  75                  80  


Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His Val Gln Val 
                85                  90                  95      


Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu Asp Gly Asp Pro Phe 
            100                 105                 110         


Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg Val Arg Val 
        115                 120                 125             


Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys Lys Gly Lys 
    130                 135                 140                 


Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp Cys Val Phe Thr Glu 
145                 150                 155                 160 


Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln Asn Ala Lys Tyr Glu 
                165                 170                 175     


Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg Pro Arg Lys Gly Ser 
            180                 185                 190         


Lys Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys Arg Leu Pro 
        195                 200                 205             


Arg Gly His His Thr Thr Glu Gln Ser Leu Arg Phe Glu Phe Leu Asn 
    210                 215                 220                 


Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser Gln Arg Thr Trp Ala 
225                 230                 235                 240 


Pro Glu Pro Arg 
                


<210>  5
<211>  215
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  5

Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Val Thr Val Gln Ser Ser Pro Asn Phe 
            20                  25                  30          


Thr Gln His Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu Ser Arg 
        35                  40                  45              


Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His 
    50                  55                  60                  


Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu Asp Gly 
65                  70                  75                  80  


Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      


Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys 
            100                 105                 110         


Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp Cys Val 
        115                 120                 125             


Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln Asn Ala 
    130                 135                 140                 


Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg Pro Arg 
145                 150                 155                 160 


Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys 
                165                 170                 175     


Arg Leu Pro Arg Gly His His Thr Thr Glu Gln Ser Leu Arg Phe Glu 
            180                 185                 190         


Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser Gln Arg 
        195                 200                 205             


Thr Trp Ala Pro Glu Pro Arg 
    210                 215 


<210>  6
<211>  197
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  6

Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Val Thr Val Gln Ser Ser Pro Asn Phe 
            20                  25                  30          


Thr Gln His Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu Ser Arg 
        35                  40                  45              


Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His 
    50                  55                  60                  


Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu Asp Gly 
65                  70                  75                  80  


Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      


Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys 
            100                 105                 110         


Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp Cys Val 
        115                 120                 125             


Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln Asn Ala 
    130                 135                 140                 


Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg Pro Arg 
145                 150                 155                 160 


Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys 
                165                 170                 175     


Arg Leu Pro Arg Gly His His Thr Thr Glu Gln Ser Leu Arg Phe Glu 
            180                 185                 190         


Phe Leu Asn Tyr Pro 
        195         


<210>  7
<211>  270
<212>  PRT
<213>  Equus caballus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  7

Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Val Arg Arg Thr Ala Arg Arg Arg Gly 
            20                  25                  30          


Pro Gly Gly Arg Arg Gly Thr Pro Val Asp Asn Val Gly Gln Gly His 
        35                  40                  45              


Glu Asp Gly Pro Cys Gly Arg Arg Gly Arg Ala Gly Arg Asn Leu Ser 
    50                  55                  60                  


Ser Pro Ala Pro Asn Tyr Pro Glu Glu Gly Ala Lys Glu Gln Arg Gly 
65                  70                  75                  80  


Ser Ala Leu Pro Lys Val Thr Gln Gln His Val Arg Glu Gln Ser Leu 
                85                  90                  95      


Val Thr Asp Gln Leu Ser Arg Arg Leu Ile Arg Thr Tyr Gln Leu Tyr 
            100                 105                 110         


Ser Arg Thr Ser Gly Lys His Val Gln Val Leu Ala Asn Lys Arg Ile 
        115                 120                 125             


Asn Ala Met Ala Glu Asp Gly Asp Pro Phe Ala Lys Leu Ile Val Glu 
    130                 135                 140                 


Thr Asp Thr Phe Gly Ser Arg Val Arg Val Arg Gly Ala Glu Thr Gly 
145                 150                 155                 160 


Leu Tyr Ile Cys Met Asn Lys Lys Gly Lys Leu Ile Ala Lys Ser Asn 
                165                 170                 175     


Gly Lys Gly Lys Asp Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn 
            180                 185                 190         


Tyr Thr Ala Leu Gln Asn Ala Lys Tyr Glu Gly Trp Tyr Met Ala Phe 
        195                 200                 205             


Thr Arg Lys Gly Arg Pro Arg Lys Gly Ser Lys Thr Arg Gln His Gln 
    210                 215                 220                 


Arg Glu Val His Phe Met Lys Arg Leu Pro Arg Gly His His Thr Thr 
225                 230                 235                 240 


Glu Gln Ser Leu Arg Phe Glu Phe Leu Asn Tyr Pro Pro Phe Thr Arg 
                245                 250                 255     


Ser Leu Arg Gly Ser Gln Arg Thr Trp Ala Pro Glu Pro Arg 
            260                 265                 270 


