                         SEQUENCE LISTING

<110>  RUBIUS THERAPEUTICS, INC.
 
<120>  METHODS OF INCREASING NKp30-POSITIVE LYMPHOCYTES IN A 
       SUBJECT AND USES THEREOF

<130>  47472-0079WO1

<150>  US 63/135,559
<151>  2021-01-08

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  177
<212>  PRT
<213>  Human

<400>  1

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala 
    130                 135                 140                 


Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Lys Tyr Ala Lys Ser Thr Leu Ser Gly Phe Pro Gln 
                165                 170                 175     


Leu 
    


<210>  2
<211>  534
<212>  DNA
<213>  Human

<400>  2
atggcctgga tgctgttgct catcttgatc atggtccatc caggatcctg tgctctctgg       60

gtgtcccagc cccctgagat tcgtaccctg gaaggatcct ctgccttcct gccctgctcc      120

ttcaatgcca gccaagggag actggccatt ggctccgtca cgtggttccg agatgaggtg      180

gttccaggga aggaggtgag gaatggaacc ccagagttca ggggccgcct ggccccactt      240

gcttcttccc gtttcctcca tgaccaccag gctgagctgc acatccggga cgtgcgaggc      300

catgacgcca gcatctacgt gtgcagagtg gaggtgctgg gccttggtgt cgggacaggg      360

aatgggactc ggctggtggt ggagaaagaa catcctcagc taggggctgg tacagtcctc      420

ctccttcggg ctggattcta tgctgtcagc tttctctctg tggccgtggg cagcaccgtc      480

tattaccagg gcaaatatgc caaatctact ctctccggat tcccccaact ctga            534


<210>  3
<211>  190
<212>  PRT
<213>  Human

<400>  3

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala 
    130                 135                 140                 


Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Lys Cys His Cys His Met Gly Thr His Cys His Ser 
                165                 170                 175     


Ser Asp Gly Pro Arg Gly Val Ile Pro Glu Pro Arg Cys Pro 
            180                 185                 190 


<210>  4
<211>  573
<212>  DNA
<213>  Human

<400>  4
atggcctgga tgctgttgct catcttgatc atggtccatc caggatcctg tgctctctgg       60

gtgtcccagc cccctgagat tcgtaccctg gaaggatcct ctgccttcct gccctgctcc      120

ttcaatgcca gccaagggag actggccatt ggctccgtca cgtggttccg agatgaggtg      180

gttccaggga aggaggtgag gaatggaacc ccagagttca ggggccgcct ggccccactt      240

gcttcttccc gtttcctcca tgaccaccag gctgagctgc acatccggga cgtgcgaggc      300

catgacgcca gcatctacgt gtgcagagtg gaggtgctgg gccttggtgt cgggacaggg      360

aatgggactc ggctggtggt ggagaaagaa catcctcagc taggggctgg tacagtcctc      420

ctccttcggg ctggattcta tgctgtcagc tttctctctg tggccgtggg cagcaccgtc      480

tattaccagg gcaaatgcca ctgtcacatg ggaacacact gccactcctc agatgggccc      540

cgaggagtga ttccagagcc cagatgtccc tag                                   573


<210>  5
<211>  201
<212>  PRT
<213>  Human

<400>  5

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala 
    130                 135                 140                 


Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg Gln Leu 
                165                 170                 175     


Pro Ala Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser Ser Ala 
            180                 185                 190         


His Leu Leu Pro Pro Val Pro Gly Gly 
        195                 200     


<210>  6
<211>  607
<212>  DNA
<213>  Human

<400>  6
catggcctgg atgctgttgc tcatcttgat catggtccat ccaggatcct gtgctctctg       60

ggtgtcccag ccccctgaga ttcgtaccct ggaaggatcc tctgccttcc tgccctgctc      120

cttcaatgcc agccaaggga gactggccat tggctccgtc acgtggttcc gagatgaggt      180

ggttccaggg aaggaggtga ggaatggaac cccagagttc aggggccgcc tggccccact      240

tgcttcttcc cgtttcctcc atgaccacca ggctgagctg cacatccggg acgtgcgagg      300

ccatgacgcc agcatctacg tgtgcagagt ggaggtgctg ggccttggtg tcgggacagg      360

gaatgggact cggctggtgg tggagaaaga acatcctcag ctaggggctg gtacagtcct      420

cctccttcgg gctggattct atgctgtcag ctttctctct gtggccgtgg gcagcaccgt      480

ctattaccag ggcaaatgtc tgacctggaa aggtccaaga aggcagctgc cggctgtggt      540

cccagcgccc ctcccaccac catgtgggag ctcagcacat ctgcttcccc cagtcccagg      600

aggctga                                                                607


<210>  7
<211>  454
<212>  PRT
<213>  Human

<400>  7

Met Thr Trp Arg Ala Ala Ala Ser Thr Cys Ala Ala Leu Leu Ile Leu 
1               5                   10                  15      


Leu Trp Ala Leu Thr Thr Glu Gly Asp Leu Lys Val Glu Met Met Ala 
            20                  25                  30          


Gly Gly Thr Gln Ile Thr Pro Leu Asn Asp Asn Val Thr Ile Phe Cys 
        35                  40                  45              


Asn Ile Phe Tyr Ser Gln Pro Leu Asn Ile Thr Ser Met Gly Ile Thr 
    50                  55                  60                  


Trp Phe Trp Lys Ser Leu Thr Phe Asp Lys Glu Val Lys Val Phe Glu 
65                  70                  75                  80  


Phe Phe Gly Asp His Gln Glu Ala Phe Arg Pro Gly Ala Ile Val Ser 
                85                  90                  95      


Pro Trp Arg Leu Lys Ser Gly Asp Ala Ser Leu Arg Leu Pro Gly Ile 
            100                 105                 110         


Gln Leu Glu Glu Ala Gly Glu Tyr Arg Cys Glu Val Val Val Thr Pro 
        115                 120                 125             


Leu Lys Ala Gln Gly Thr Val Gln Leu Glu Val Val Ala Ser Pro Ala 
    130                 135                 140                 


Ser Arg Leu Leu Leu Asp Gln Val Gly Met Lys Glu Asn Glu Asp Lys 
145                 150                 155                 160 


Tyr Met Cys Glu Ser Ser Gly Phe Tyr Pro Glu Ala Ile Asn Ile Thr 
                165                 170                 175     


Trp Glu Lys Gln Thr Gln Lys Phe Pro His Pro Ile Glu Ile Ser Glu 
            180                 185                 190         


Asp Val Ile Thr Gly Pro Thr Ile Lys Asn Met Asp Gly Thr Phe Asn 
        195                 200                 205             


Val Thr Ser Cys Leu Lys Leu Asn Ser Ser Gln Glu Asp Pro Gly Thr 
    210                 215                 220                 


Val Tyr Gln Cys Val Val Arg His Ala Ser Leu His Thr Pro Leu Arg 
225                 230                 235                 240 


Ser Asn Phe Thr Leu Thr Ala Ala Arg His Ser Leu Ser Glu Thr Glu 
                245                 250                 255     


Lys Thr Asp Asn Phe Ser Ile His Trp Trp Pro Ile Ser Phe Ile Gly 
            260                 265                 270         


Val Gly Leu Val Leu Leu Ile Val Leu Ile Pro Trp Lys Lys Ile Cys 
        275                 280                 285             


Asn Lys Ser Ser Ser Ala Tyr Thr Pro Leu Lys Cys Ile Leu Lys His 
    290                 295                 300                 


Trp Asn Ser Phe Asp Thr Gln Thr Leu Lys Lys Glu His Leu Ile Phe 
305                 310                 315                 320 


Phe Cys Thr Arg Ala Trp Pro Ser Tyr Gln Leu Gln Asp Gly Glu Ala 
                325                 330                 335     


Trp Pro Pro Glu Gly Ser Val Asn Ile Asn Thr Ile Gln Gln Leu Asp 
            340                 345                 350         


Val Phe Cys Arg Gln Glu Gly Lys Trp Ser Glu Val Pro Tyr Val Gln 
        355                 360                 365             


Ala Phe Phe Ala Leu Arg Asp Asn Pro Asp Leu Cys Gln Cys Cys Arg 
    370                 375                 380                 


Ile Asp Pro Ala Leu Leu Thr Val Thr Ser Gly Lys Ser Ile Asp Asp 
385                 390                 395                 400 


Asn Ser Thr Lys Ser Glu Lys Gln Thr Pro Arg Glu His Ser Asp Ala 
                405                 410                 415     


Val Pro Asp Ala Pro Ile Leu Pro Val Ser Pro Ile Trp Glu Pro Pro 
            420                 425                 430         


Pro Ala Thr Thr Ser Thr Thr Pro Val Leu Ser Ser Gln Pro Pro Thr 
        435                 440                 445             


Leu Leu Leu Pro Leu Gln 
    450                 


<210>  8
<211>  1365
<212>  DNA
<213>  Human

<400>  8
atgacgtgga gggctgccgc ctccacgtgc gcggcgctcc tgattctgct gtgggcgctg       60

acgaccgaag gtgatctgaa agtagagatg atggcagggg ggactcagat cacacccctg      120

aatgacaatg tcaccatatt ctgcaatatc ttttattccc aacccctcaa catcacgtct      180

atgggtatca cctggttttg gaagagtctg acgtttgaca aagaagtcaa agtctttgaa      240

ttttttggag atcaccaaga ggcattccga cctggagcca ttgtgtctcc atggaggctg      300

aagagtgggg acgcctcact gcggctgcct ggaatccagc tggaggaagc aggagagtac      360

cgatgtgagg tggtggtcac ccctctgaag gcacagggaa cagtccagct tgaagttgtg      420

gcttccccag ccagcagatt gttgctggat caagtgggca tgaaagagaa tgaagacaaa      480

tatatgtgtg agtcaagtgg gttctaccca gaggctatta atataacatg ggagaagcag      540

acccagaagt ttccccatcc catagagatt tctgaggatg tcatcactgg tcccaccatc      600

aagaatatgg atggcacatt taatgtcact agctgcttga agctgaactc ctctcaggaa      660

gaccctggga ctgtctacca gtgtgtggta cggcatgcgt ccttgcatac ccccttgagg      720

agcaacttta ccctgactgc tgctcggcac agtctttctg aaactgagaa gacagataat      780

ttttccattc attggtggcc tatttcattc attggtgttg gactggtttt attaattgtt      840

ttgattcctt ggaaaaagat atgtaacaaa tcatcttcag cctatactcc tctcaagtgc      900

attctgaaac actggaactc ctttgacact cagactctga agaaagagca cctcatattc      960

ttttgcactc gggcatggcc gtcttaccag ctgcaggatg gggaggcttg gcctcctgag     1020

ggaagtgtta atattaatac tattcaacaa ctagatgttt tctgcagaca ggagggcaaa     1080

tggtccgagg ttccttatgt gcaagccttc tttgccttgc gagacaaccc agatctttgt     1140

cagtgttgta gaattgaccc tgctctccta acagttacat caggcaagtc catagatgat     1200

aattccacaa agtctgagaa acaaacccct agggaacact cggatgcagt tccggatgcc     1260

ccaatccttc ctgtctcccc tatctgggaa cctcctccag ccacaacatc aacaactcca     1320

gttctatcct cccaaccccc aactttactg ttacccctac agtaa                     1365


<210>  9
<211>  233
<212>  PRT
<213>  Human

<400>  9

Met Asp Asn Gln Gly Val Ile Tyr Ser Asp Leu Asn Leu Pro Pro Asn 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Asn Ser Ile Leu 
            20                  25                  30          


Ala Thr Glu Gln Glu Ile Thr Tyr Ala Glu Leu Asn Leu Gln Lys Ala 
        35                  40                  45              


Ser Gln Asp Phe Gln Gly Asn Asp Lys Thr Tyr His Cys Lys Asp Leu 
    50                  55                  60                  


Pro Ser Ala Pro Glu Lys Leu Ile Val Gly Ile Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Leu Ile Leu Met Ala Ser Val Val Thr Ile Val Val Ile Pro Ser Thr 
                85                  90                  95      


Leu Ile Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys 
            100                 105                 110         


Ala Arg His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn 
        115                 120                 125             


Ser Cys Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu 
    130                 135                 140                 


Leu Ala Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn Glu 
145                 150                 155                 160 


Glu Glu Met Lys Phe Leu Ser Ile Ile Ser Pro Ser Ser Trp Ile Gly 
                165                 170                 175     


Val Phe Arg Asn Ser Ser His His Pro Trp Val Thr Met Asn Gly Leu 
            180                 185                 190         


Ala Phe Lys His Glu Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn Cys 
        195                 200                 205             


Ala Val Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser Ser 
    210                 215                 220                 


Ile Ile Tyr His Cys Lys His Lys Leu 
225                 230             


<210>  10
<211>  702
<212>  DNA
<213>  Human

<400>  10
atggataacc aaggagtaat ctactcagac ctgaatctgc ccccaaaccc aaagaggcag       60

caacgaaaac ctaaaggcaa taaaaactcc attttagcaa ctgaacagga aataacctat      120

gcggaattaa accttcaaaa agcttctcag gattttcaag ggaatgacaa aacctatcac      180

tgcaaagatt taccatcagc tccagagaag ctcattgttg ggatcctggg aattatctgt      240

cttatcttaa tggcctctgt ggtaacgata gttgttattc cctctacatt aatacagagg      300

cacaacaatt cttccctgaa tacaagaact cagaaagcac gtcattgtgg ccattgtcct      360

gaggagtgga ttacatattc caacagttgt tactacattg gtaaggaaag aagaacttgg      420

gaagagagtt tgctggcctg tacttcgaag aactccagtc tgctttctat agataatgaa      480

gaagaaatga aatttctgtc catcatttca ccatcctcat ggattggtgt gtttcgtaac      540

agcagtcatc atccatgggt gacaatgaat ggtttggctt tcaaacatga gataaaagac      600

tcagataatg ctgaacttaa ctgtgcagtg ctacaagtaa atcgacttaa atcagcccag      660

tgtggatctt caataatata tcattgtaag cataagcttt ag                         702


<210>  11
<211>  233
<212>  PRT
<213>  Human

<400>  11

Met Asp Asn Gln Gly Val Ile Tyr Ser Asp Leu Asn Leu Pro Pro Asn 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Leu 
            20                  25                  30          


Ala Thr Glu Gln Glu Ile Thr Tyr Ala Glu Leu Asn Leu Gln Lys Ala 
        35                  40                  45              


Ser Gln Asp Phe Gln Gly Asn Asp Lys Thr Tyr His Cys Lys Asp Leu 
    50                  55                  60                  


Pro Ser Ala Pro Glu Lys Leu Ile Val Gly Ile Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Leu Ile Leu Met Ala Ser Val Val Thr Ile Val Val Ile Pro Ser Thr 
                85                  90                  95      


Leu Ile Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys 
            100                 105                 110         


Ala Arg His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn 
        115                 120                 125             


Ser Cys Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu 
    130                 135                 140                 


Leu Ala Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn Glu 
145                 150                 155                 160 


Glu Glu Met Lys Phe Leu Ser Ile Ile Ser Pro Ser Ser Trp Ile Gly 
                165                 170                 175     


Val Phe Arg Asn Ser Ser His His Pro Trp Val Thr Met Asn Gly Leu 
            180                 185                 190         


Ala Phe Lys His Glu Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn Cys 
        195                 200                 205             


Ala Val Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser Ser 
    210                 215                 220                 


Ile Ile Tyr His Cys Lys His Lys Leu 
225                 230             


<210>  12
<211>  702
<212>  DNA
<213>  Human

<400>  12
atggataacc aaggagtaat ctactcagac ctgaatctgc ccccaaaccc aaagaggcag       60

caacgaaaac ctaaaggcaa taaaaactcc attttagcaa ctgaacagga aataacctat      120

gcggaattaa accttcaaaa agcttctcag gattttcaag ggaatgacaa aacctatcac      180

tgcaaagatt taccatcagc tccagagaag ctcattgttg ggatcctggg aattatctgt      240

cttatcttaa tggcctctgt ggtaacgata gttgttattc cctctacatt aatacagagg      300

cacaacaatt cttccctgaa tacaagaact cagaaagcac gtcattgtgg ccattgtcct      360

gaggagtgga ttacatattc caacagttgt tactacattg gtaaggaaag aagaacttgg      420

gaagagagtt tgctggcctg tacttcgaag aactccagtc tgctttctat agataatgaa      480

gaagaaatga aatttctgtc catcatttca ccatcctcat ggattggtgt gtttcgtaac      540

agcagtcatc atccatgggt gacaatgaat ggtttggctt tcaaacatga gataaaagac      600

tcagataatg ctgaacttaa ctgtgcagtg ctacaagtaa atcgacttaa atcagcccag      660

tgtggatctt caataatata tcattgtaag cataagcttt ag                         702


<210>  13
<211>  358
<212>  PRT
<213>  Human

<400>  13

Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro 
    50                  55                  60                  


Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 
65                  70                  75                  80  


Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 
                85                  90                  95      


Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Gly 
        115                 120                 125             


Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala 
145                 150                 155                 160 


Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His 
                165                 170                 175     


Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr 
            180                 185                 190         


Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr 
        195                 200                 205             


His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 
225                 230                 235                 240 


Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
                325                 330                 335     


Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Glu Ser His Ser Leu 
        355             


<210>  14
<211>  1077
<212>  DNA
<213>  Human

<400>  14
atggtagatg gaaccctcct tttactcctc tcggaggccc tggcccttac ccagacctgg       60

gcgggctccc actccttgaa gtatttccac acttccgtgt cccggcccgg ccgcggggag      120

ccccgcttca tctctgtggg ctacgtggac gacacccagt tcgtgcgctt cgacaacgac      180

gccgcgagtc cgaggatggt gccgcgggcg ccgtggatgg agcaggaggg gtcagagtat      240

tgggaccggg agacacggag cgccagggac accgcacaga ttttccgagt gaatctgcgg      300

acgctgcgcg gctactacaa tcagagcgag gccgggtctc acaccctgca gtggatgcat      360

ggctgcgagc tggggcccga cgggcgcttc ctccgcgggt atgaacagtt cgcctacgac      420

ggcaaggatt atctcaccct gaatgaggac ctgcgctcct ggaccgcggt ggacacggcg      480

gctcagatct ccgagcaaaa gtcaaatgat gcctctgagg cggagcacca gagagcctac      540

ctggaagaca catgcgtgga gtggctccac aaatacctgg agaaggggaa ggagacgctg      600

cttcacctgg agcccccaaa gacacacgtg actcaccacc ccatctctga ccatgaggcc      660

accctgaggt gctgggccct gggcttctac cctgcggaga tcacactgac ctggcagcag      720

gatggggagg gccataccca ggacacggag ctcgtggaga ccaggcctgc aggggatgga      780

accttccaga agtgggcagc tgtggtggtg ccttctggag aggagcagag atacacgtgc      840

catgtgcagc atgaggggct acccgagccc gtcaccctga gatggaagcc ggcttcccag      900

cccaccatcc ccatcgtggg catcattgct ggcctggttc tccttggatc tgtggtctct      960

ggagctgtgg ttgctgctgt gatatggagg aagaagagct caggtggaaa aggagggagc     1020

tactctaagg ctgagtggag cgacagtgcc caggggtctg agtctcacag cttgtaa        1077


<210>  15
<211>  162
<212>  PRT
<213>  Human

<400>  15

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  16
<211>  114
<212>  PRT
<213>  Human

<400>  16

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  17
<211>  342
<212>  DNA
<213>  Human

<400>  17
aactgggtga acgttattag tgaccttaaa aagatcgaag atttgataca gtcaatgcac       60

atagacgcga cgctttatac agaatctgat gtacatcctt catgcaaggt tactgctatg      120

aagtgttttc ttctcgaact ccaagtaata agtcttgaga gcggagatgc gagcattcat      180

gacaccgttg agaatcttat tatattggct aacaactctc tgtccagcaa tggtaatgtg      240

acagaaagcg ggtgtaagga gtgcgaggaa ctcgaggaga agaacatcaa agagttcttg      300

cagtctttcg tccatattgt ccagatgttc ataaatacta gc                         342


<210>  18
<211>  342
<212>  DNA
<213>  Human

<400>  18
aactgggtaa acgtcataag cgacctcaaa aagatcgagg accttataca gtctatgcac       60

atagatgcga cactttacac ggaatcagac gtgcacccgt cctgcaaagt cacagccatg      120

aagtgctttc ttctcgaact gcaggtaatt tctctcgaat caggtgacgc atctatccac      180

gacacagttg aaaatcttat tatcctggct aataactccc ttagctcaaa cggcaatgtc      240

accgagagtg gatgtaaaga atgtgaggaa cttgaagaga aaaacataaa ggaattcttg      300

cagagtttcg ttcatattgt gcaaatgttc atcaatacta gt                         342


<210>  19
<211>  267
<212>  PRT
<213>  Human

<400>  19

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  20
<211>  237
<212>  PRT
<213>  Human

<400>  20

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val 
                165                 170                 175     


Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser 
            180                 185                 190         


Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser 
        195                 200                 205             


Val Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser 
    210                 215                 220                 


Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
225                 230                 235         


<210>  21
<211>  205
<212>  PRT
<213>  Human

<400>  21

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
        195                 200                 205 


<210>  22
<211>  175
<212>  PRT
<213>  Human

<400>  22

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                165                 170                 175 


<210>  23
<211>  525
<212>  DNA
<213>  Human

<400>  23
atcacatgcc caccgcccat gtctgttgaa cacgcagaca tttgggttaa aagttactca       60

ctttactcac gcgagagata tatatgcaac agcggcttca agcgcaaagc aggcactagt      120

agtcttacag agtgcgtgct caataaagct acaaatgtag ctcattggac tactcctagt      180

ctcaaatgca ttcgggaccc cgcgcttgtg caccagagac ctgcgccgcc gtccacagtg      240

acgacagctg gtgtaacccc ccaacctgaa tcccttagtc cgtctggtaa agaaccggcg      300

gcgtcttcac cttccagcaa taatactgcg gcgacaacag ccgcgatagt tcctggatcc      360

caactcatgc cgtcaaagtc tccttcaacg ggaacgacag agatctcttc acatgaaagt      420

tctcatggaa caccgagcca aactacggca aagaactggg aactgactgc ctcagcaagc      480

caccagccgc caggggtgta cccgcaaggg cactcagata ctact                      525


<210>  24
<211>  65
<212>  PRT
<213>  Artificial

<220>
<223>  Human IL-15 receptor sushi domain

<400>  24

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg 
65  


<210>  25
<211>  78
<212>  PRT
<213>  Artificial

<220>
<223>  Human IL-15 receptor sushi domain + 13 aa of IL-15 receptor alpha

<400>  25

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser 
65                  70                  75              


<210>  26
<211>  234
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence encoding SEQ ID NO: 25

<400>  26
atcacctgcc cgcctcccat gagcgtggaa cacgcggaca tttgggttaa gagctacagt       60

ctttacagcc gggagcgcta tatctgcaac tcagggttta agcggaaagc agggacatca      120

agtttgacag aatgtgtgtt gaacaaggct acaaatgttg ctcactggac cacgccatct      180

ttgaagtgta tccgagatcc cgcgcttgtc catcagcgcc cagcgcctcc ctcc            234


<210>  27
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  GPA signal peptide

<400>  27

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala 
            


<210>  28
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid encoding SEQ ID NO: 27

<400>  28
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagca          57


<210>  29
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  29

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  30
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  n = 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10

<400>  30

Gly Gly Gly Gly Ser Asn 
1               5       


<210>  31
<211>  304
<212>  PRT
<213>  Artificial

<220>
<223>  Mature human IL-15 + (G4S)3 linker + mature extracellular soluble
       human IL-15 receptor alpha

<400>  31

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
    130                 135                 140                 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
145                 150                 155                 160 


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
                165                 170                 175     


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
            180                 185                 190         


Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr 
        195                 200                 205             


Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser 
    210                 215                 220                 


Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala 
225                 230                 235                 240 


Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser 
                245                 250                 255     


Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly 
            260                 265                 270         


Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala 
        275                 280                 285             


Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
    290                 295                 300                 


<210>  32
<211>  912
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence encoding SEQ ID NO: 31

<400>  32
aactgggtga acgttattag tgaccttaaa aagatcgaag atttgataca gtcaatgcac       60

atagacgcga cgctttatac agaatctgat gtacatcctt catgcaaggt tactgctatg      120

aagtgttttc ttctcgaact ccaagtaata agtcttgaga gcggagatgc gagcattcat      180

gacaccgttg agaatcttat tatattggct aacaactctc tgtccagcaa tggtaatgtg      240

acagaaagcg ggtgtaagga gtgcgaggaa ctcgaggaga agaacatcaa agagttcttg      300

cagtctttcg tccatattgt ccagatgttc ataaatacta gcgggggagg tggctctggt      360

ggaggcggga gtggcggggg cggctcaatc acatgcccac cgcccatgtc tgttgaacac      420

gcagacattt gggttaaaag ttactcactt tactcacgcg agagatatat atgcaacagc      480

ggcttcaagc gcaaagcagg cactagtagt cttacagagt gcgtgctcaa taaagctaca      540

aatgtagctc attggactac tcctagtctc aaatgcattc gggaccccgc gcttgtgcac      600

cagagacctg cgccgccgtc cacagtgacg acagctggtg taacccccca acctgaatcc      660

cttagtccgt ctggtaaaga accggcggcg tcttcacctt ccagcaataa tactgcggcg      720

acaacagccg cgatagttcc tggatcccaa ctcatgccgt caaagtctcc ttcaacggga      780

acgacagaga tctcttcaca tgaaagttct catggaacac cgagccaaac tacggcaaag      840

aactgggaac tgactgcctc agcaagccac cagccgccag gggtgtaccc gcaagggcac      900

tcagatacta ct                                                          912


<210>  33
<211>  207
<212>  PRT
<213>  Artificial

<220>
<223>  Mature human IL-15  + (G4S)3 linker + IL-15 receptor alpha sushi 
       domain + 13 aa of IL-15 receptor alpha

<400>  33

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
    130                 135                 140                 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
145                 150                 155                 160 


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
                165                 170                 175     


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
            180                 185                 190         


Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser 
        195                 200                 205         


<210>  34
<211>  621
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence encoding SEQ ID NO: 33

<400>  34
aactgggtaa acgtcataag cgacctcaaa aagatcgagg accttataca gtctatgcac       60

atagatgcga cactttacac ggaatcagac gtgcacccgt cctgcaaagt cacagccatg      120

aagtgctttc ttctcgaact gcaggtaatt tctctcgaat caggtgacgc atctatccac      180

gacacagttg aaaatcttat tatcctggct aataactccc ttagctcaaa cggcaatgtc      240

accgagagtg gatgtaaaga atgtgaggaa cttgaagaga aaaacataaa ggaattcttg      300

cagagtttcg ttcatattgt gcaaatgttc atcaatacta gtggcggggg gggaagcggt      360

ggtggaggga gcgggggtgg tggatccatc acctgcccgc ctcccatgag cgtggaacac      420

gcggacattt gggttaagag ctacagtctt tacagccggg agcgctatat ctgcaactca      480

gggtttaagc ggaaagcagg gacatcaagt ttgacagaat gtgtgttgaa caaggctaca      540

aatgttgctc actggaccac gccatctttg aagtgtatcc gagatcccgc gcttgtccat      600

cagcgcccag cgcctccctc c                                                621


<210>  35
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  35

Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  


<210>  36
<211>  131
<212>  PRT
<213>  Artificial

<220>
<223>  GPA polypeptide

<400>  36

Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser Ser Ser Val 
1               5                   10                  15      


Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp 
            20                  25                  30          


Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu Ile Ser Val 
        35                  40                  45              


Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu 
    50                  55                  60                  


Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val 
65                  70                  75                  80  


Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg 
                85                  90                  95      


Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro 
            100                 105                 110         


Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr 
        115                 120                 125             


Ser Asp Gln 
    130     


<210>  37
<211>  393
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence encoding SEQ ID NO: 36

<400>  37
ttaagtacca ctgaggtggc aatgcacact tcaacctctt cttcagtcac aaagagttac       60

atctcatcac agacaaatga tacgcacaaa cgggacacat atgcagccac tcctagagct      120

catgaagttt cagaaatttc tgttagaact gtttaccctc cagaagagga aaccggagaa      180

agggtacaac ttgcccatca tttctctgaa ccagagataa cactcattat ttttggggtg      240

atggctggtg ttattggaac gatcctctta atttcttacg gtattcgccg actgataaag      300

aaaagcccat ctgatgtaaa acctctcccc tcacctgaca cagacgtgcc tttaagttct      360

gttgaaatag aaaatccaga gacaagtgat caa                                   393


<210>  38
<211>  289
<212>  PRT
<213>  Artificial

<220>
<223>  IL-15 V3 construct

<400>  38

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser Gly Gly Ser Gly Gly Ser Gly Gly Tyr Pro Tyr 
    130                 135                 140                 


Asp Val Pro Asp Tyr Ala Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser 
145                 150                 155                 160 


Thr Thr Glu Val Ala Met His Thr Ser Thr Ser Ser Ser Val Thr Lys 
                165                 170                 175     


Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr 
            180                 185                 190         


Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu Ile Ser Val Arg Thr 
        195                 200                 205             


Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His 
    210                 215                 220                 


His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala 
225                 230                 235                 240 


Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Leu 
                245                 250                 255     


Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro Asp Thr 
            260                 265                 270         


Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr Ser Asp 
        275                 280                 285             


Gln 
    


<210>  39
<211>  867
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence encoding SEQ ID NO:38 (IL-15 V3)

<400>  39
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagcaaac       60

tgggtaaatg tgatttcaga cctgaaaaaa atcgaagacc ttattcaatc catgcacatc      120

gacgcgacac tttatactga atcagacgta cacccgtcct gtaaggttac tgcgatgaag      180

tgctttctgt tggaattgca agtgatctcc ctcgaatcag gggatgcatc cattcatgat      240

accgtcgaga atttgatcat tctggcaaat aactccctca gtagtaacgg gaatgtgacc      300

gagtctgggt gtaaggagtg cgaagagttg gaggaaaaga atatcaaaga attccttcag      360

tcctttgttc acatcgtgca aatgtttatt aatacatctg gaggatctgg cgggtctgga      420

ggctacccct atgacgtgcc cgactatgcc ggcggagggt ctggaggcgg ttccttaagt      480

accactgagg tggcaatgca cacttcaacc tcttcttcag tcacaaagag ttacatctca      540

tcacagacaa atgatacgca caaacgggac acatatgcag ccactcctag agctcatgaa      600

gtttcagaaa tttctgttag aactgtttac cctccagaag aggaaaccgg agaaagggta      660

caacttgccc atcatttctc tgaaccagag ataacactca ttatttttgg ggtgatggct      720

ggtgttattg gaacgatcct cttaatttct tacggtattc gccgactgat aaagaaaagc      780

ccatctgatg taaaacctct cccctcacct gacacagacg tgcctttaag ttctgttgaa      840

atagaaaatc cagagacaag tgatcaa                                          867


<210>  40
<211>  479
<212>  PRT
<213>  Artificial

<220>
<223>  IL-15/IL-15Ra V4 construct

<400>  40

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
145                 150                 155                 160 


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
                165                 170                 175     


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
            180                 185                 190         


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
        195                 200                 205             


Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro 
    210                 215                 220                 


Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu 
225                 230                 235                 240 


Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn 
                245                 250                 255     


Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro 
            260                 265                 270         


Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser 
        275                 280                 285             


Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr 
    290                 295                 300                 


Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser 
305                 310                 315                 320 


Asp Thr Thr Gly Gly Ser Gly Gly Ser Gly Gly Tyr Pro Tyr Asp Val 
                325                 330                 335     


Pro Asp Tyr Ala Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Thr Thr 
            340                 345                 350         


Glu Val Ala Met His Thr Ser Thr Ser Ser Ser Val Thr Lys Ser Tyr 
        355                 360                 365             


Ile Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr Ala Ala 
    370                 375                 380                 


Thr Pro Arg Ala His Glu Val Ser Glu Ile Ser Val Arg Thr Val Tyr 
385                 390                 395                 400 


Pro Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His His Phe 
                405                 410                 415     


Ser Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly Val 
            420                 425                 430         


Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Leu Ile Lys 
        435                 440                 445             


Lys Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro Asp Thr Asp Val 
    450                 455                 460                 


Pro Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr Ser Asp Gln 
465                 470                 475                 


<210>  41
<211>  1437
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence encoding SEQ ID NO:40 (IL-15-V4)

<400>  41
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagcaaac       60

tgggtgaacg ttattagtga ccttaaaaag atcgaagatt tgatacagtc aatgcacata      120

gacgcgacgc tttatacaga atctgatgta catccttcat gcaaggttac tgctatgaag      180

tgttttcttc tcgaactcca agtaataagt cttgagagcg gagatgcgag cattcatgac      240

accgttgaga atcttattat attggctaac aactctctgt ccagcaatgg taatgtgaca      300

gaaagcgggt gtaaggagtg cgaggaactc gaggagaaga acatcaaaga gttcttgcag      360

tctttcgtcc atattgtcca gatgttcata aatactagcg ggggaggtgg ctctggtgga      420

ggcgggagtg gcgggggcgg ctcaatcaca tgcccaccgc ccatgtctgt tgaacacgca      480

gacatttggg ttaaaagtta ctcactttac tcacgcgaga gatatatatg caacagcggc      540

ttcaagcgca aagcaggcac tagtagtctt acagagtgcg tgctcaataa agctacaaat      600

gtagctcatt ggactactcc tagtctcaaa tgcattcggg accccgcgct tgtgcaccag      660

agacctgcgc cgccgtccac agtgacgaca gctggtgtaa ccccccaacc tgaatccctt      720

agtccgtctg gtaaagaacc ggcggcgtct tcaccttcca gcaataatac tgcggcgaca      780

acagccgcga tagttcctgg atcccaactc atgccgtcaa agtctccttc aacgggaacg      840

acagagatct cttcacatga aagttctcat ggaacaccga gccaaactac ggcaaagaac      900

tgggaactga ctgcctcagc aagccaccag ccgccagggg tgtacccgca agggcactca      960

gatactactg gaggatctgg cgggtctgga ggctacccct atgacgtgcc cgactatgcc     1020

ggcggagggt ctggaggcgg ttccttaagt accactgagg tggcaatgca cacttcaacc     1080

tcttcttcag tcacaaagag ttacatctca tcacagacaa atgatacgca caaacgggac     1140

acatatgcag ccactcctag agctcatgaa gtttcagaaa tttctgttag aactgtttac     1200

cctccagaag aggaaaccgg agaaagggta caacttgccc atcatttctc tgaaccagag     1260

ataacactca ttatttttgg ggtgatggct ggtgttattg gaacgatcct cttaatttct     1320

tacggtattc gccgactgat aaagaaaagc ccatctgatg taaaacctct cccctcacct     1380

gacacagacg tgcctttaag ttctgttgaa atagaaaatc cagagacaag tgatcaa        1437


<210>  42
<211>  382
<212>  PRT
<213>  Artificial

<220>
<223>  IL-15/IL-15Ra V5

<400>  42

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
145                 150                 155                 160 


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
                165                 170                 175     


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
            180                 185                 190         


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
        195                 200                 205             


Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro 
    210                 215                 220                 


Pro Ser Gly Gly Ser Gly Gly Ser Gly Gly Tyr Pro Tyr Asp Val Pro 
225                 230                 235                 240 


Asp Tyr Ala Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Thr Thr Glu 
                245                 250                 255     


Val Ala Met His Thr Ser Thr Ser Ser Ser Val Thr Lys Ser Tyr Ile 
            260                 265                 270         


Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr Ala Ala Thr 
        275                 280                 285             


Pro Arg Ala His Glu Val Ser Glu Ile Ser Val Arg Thr Val Tyr Pro 
    290                 295                 300                 


Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His His Phe Ser 
305                 310                 315                 320 


Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly Val Ile 
                325                 330                 335     


Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Leu Ile Lys Lys 
            340                 345                 350         


Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro Asp Thr Asp Val Pro 
        355                 360                 365             


Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr Ser Asp Gln 
    370                 375                 380         


<210>  43
<211>  1146
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence encoding SEQ ID NO:42 (IL-15 V5)

<400>  43
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagcaaac       60

tgggtaaacg tcataagcga cctcaaaaag atcgaggacc ttatacagtc tatgcacata      120

gatgcgacac tttacacgga atcagacgtg cacccgtcct gcaaagtcac agccatgaag      180

tgctttcttc tcgaactgca ggtaatttct ctcgaatcag gtgacgcatc tatccacgac      240

acagttgaaa atcttattat cctggctaat aactccctta gctcaaacgg caatgtcacc      300

gagagtggat gtaaagaatg tgaggaactt gaagagaaaa acataaagga attcttgcag      360

agtttcgttc atattgtgca aatgttcatc aatactagtg gcgggggggg aagcggtggt      420

ggagggagcg ggggtggtgg atccatcacc tgcccgcctc ccatgagcgt ggaacacgcg      480

gacatttggg ttaagagcta cagtctttac agccgggagc gctatatctg caactcaggg      540

tttaagcgga aagcagggac atcaagtttg acagaatgtg tgttgaacaa ggctacaaat      600

gttgctcact ggaccacgcc atctttgaag tgtatccgag atcccgcgct tgtccatcag      660

cgcccagcgc ctccctccgg aggatctggc gggtctggag gctaccccta tgacgtgccc      720

gactatgccg gcggagggtc tggaggcggt tccttaagta ccactgaggt ggcaatgcac      780

acttcaacct cttcttcagt cacaaagagt tacatctcat cacagacaaa tgatacgcac      840

aaacgggaca catatgcagc cactcctaga gctcatgaag tttcagaaat ttctgttaga      900

actgtttacc ctccagaaga ggaaaccgga gaaagggtac aacttgccca tcatttctct      960

gaaccagaga taacactcat tatttttggg gtgatggctg gtgttattgg aacgatcctc     1020

ttaatttctt acggtattcg ccgactgata aagaaaagcc catctgatgt aaaacctctc     1080

ccctcacctg acacagacgt gcctttaagt tctgttgaaa tagaaaatcc agagacaagt     1140

gatcaa                                                                1146


<210>  44
<211>  288
<212>  PRT
<213>  Artificial

<220>
<223>  IL-15 V3.1 construct

<400>  44

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Thr 
145                 150                 155                 160 


Thr Glu Val Ala Met His Thr Ser Thr Ser Ser Ser Val Thr Lys Ser 
                165                 170                 175     


Tyr Ile Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr Ala 
            180                 185                 190         


Ala Thr Pro Arg Ala His Glu Val Ser Glu Ile Ser Val Arg Thr Val 
        195                 200                 205             


Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His His 
    210                 215                 220                 


Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly 
225                 230                 235                 240 


Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Leu Ile 
                245                 250                 255     


Lys Lys Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro Asp Thr Asp 
            260                 265                 270         


Val Pro Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr Ser Asp Gln 
        275                 280                 285             


<210>  45
<211>  864
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence encoding SEQ ID NO:44 (IL-15 V3.1)

<400>  45
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagcaaac       60

tgggtaaatg tgatttcaga cctgaaaaaa atcgaagacc ttattcaatc catgcacatc      120

gacgcgacac tttatactga atcagacgta cacccgtcct gtaaggttac tgcgatgaag      180

tgctttctgt tggaattgca agtgatctcc ctcgaatcag gggatgcatc cattcatgat      240

accgtcgaga atttgatcat tctggcaaat aactccctca gtagtaacgg gaatgtgacc      300

gagtctgggt gtaaggagtg cgaagagttg gaggaaaaga atatcaaaga attccttcag      360

tcctttgttc acatcgtgca aatgtttatt aatacatctg gaggatctgg cgggtctgga      420

ggcggcggcg gcagcggcgg cggcagcggc ggagggtctg gaggcggttc cttaagtacc      480

actgaggtgg caatgcacac ttcaacctct tcttcagtca caaagagtta catctcatca      540

cagacaaatg atacgcacaa acgggacaca tatgcagcca ctcctagagc tcatgaagtt      600

tcagaaattt ctgttagaac tgtttaccct ccagaagagg aaaccggaga aagggtacaa      660

cttgcccatc atttctctga accagagata acactcatta tttttggggt gatggctggt      720

gttattggaa cgatcctctt aatttcttac ggtattcgcc gactgataaa gaaaagccca      780

tctgatgtaa aacctctccc ctcacctgac acagacgtgc ctttaagttc tgttgaaata      840

gaaaatccag agacaagtga tcaa                                             864


<210>  46
<211>  478
<212>  PRT
<213>  Artificial

<220>
<223>  IL-15/IL-15Ra V4.1 construct

<400>  46

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
145                 150                 155                 160 


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
                165                 170                 175     


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
            180                 185                 190         


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
        195                 200                 205             


Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro 
    210                 215                 220                 


Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu 
225                 230                 235                 240 


Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn 
                245                 250                 255     


Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro 
            260                 265                 270         


Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser 
        275                 280                 285             


Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr 
    290                 295                 300                 


Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser 
305                 310                 315                 320 


Asp Thr Thr Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly 
                325                 330                 335     


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Thr Thr Glu 
            340                 345                 350         


Val Ala Met His Thr Ser Thr Ser Ser Ser Val Thr Lys Ser Tyr Ile 
        355                 360                 365             


Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr Ala Ala Thr 
    370                 375                 380                 


Pro Arg Ala His Glu Val Ser Glu Ile Ser Val Arg Thr Val Tyr Pro 
385                 390                 395                 400 


Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His His Phe Ser 
                405                 410                 415     


Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly Val Ile 
            420                 425                 430         


Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Leu Ile Lys Lys 
        435                 440                 445             


Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro Asp Thr Asp Val Pro 
    450                 455                 460                 


Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr Ser Asp Gln 
465                 470                 475             


<210>  47
<211>  1434
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence encoding SEQ ID NO:46 (IL-15-V4.1)

<400>  47
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagcaaac       60

tgggtgaacg ttattagtga ccttaaaaag atcgaagatt tgatacagtc aatgcacata      120

gacgcgacgc tttatacaga atctgatgta catccttcat gcaaggttac tgctatgaag      180

tgttttcttc tcgaactcca agtaataagt cttgagagcg gagatgcgag cattcatgac      240

accgttgaga atcttattat attggctaac aactctctgt ccagcaatgg taatgtgaca      300

gaaagcgggt gtaaggagtg cgaggaactc gaggagaaga acatcaaaga gttcttgcag      360

tctttcgtcc atattgtcca gatgttcata aatactagcg ggggaggtgg ctctggtgga      420

ggcgggagtg gcgggggcgg ctcaatcaca tgcccaccgc ccatgtctgt tgaacacgca      480

gacatttggg ttaaaagtta ctcactttac tcacgcgaga gatatatatg caacagcggc      540

ttcaagcgca aagcaggcac tagtagtctt acagagtgcg tgctcaataa agctacaaat      600

gtagctcatt ggactactcc tagtctcaaa tgcattcggg accccgcgct tgtgcaccag      660

agacctgcgc cgccgtccac agtgacgaca gctggtgtaa ccccccaacc tgaatccctt      720

agtccgtctg gtaaagaacc ggcggcgtct tcaccttcca gcaataatac tgcggcgaca      780

acagccgcga tagttcctgg atcccaactc atgccgtcaa agtctccttc aacgggaacg      840

acagagatct cttcacatga aagttctcat ggaacaccga gccaaactac ggcaaagaac      900

tgggaactga ctgcctcagc aagccaccag ccgccagggg tgtacccgca agggcactca      960

gatactactg gaggatctgg cgggtctgga ggcggcggcg gcagcggcgg cggcagcggc     1020

ggagggtctg gaggcggttc cttaagtacc actgaggtgg caatgcacac ttcaacctct     1080

tcttcagtca caaagagtta catctcatca cagacaaatg atacgcacaa acgggacaca     1140

tatgcagcca ctcctagagc tcatgaagtt tcagaaattt ctgttagaac tgtttaccct     1200

ccagaagagg aaaccggaga aagggtacaa cttgcccatc atttctctga accagagata     1260

acactcatta tttttggggt gatggctggt gttattggaa cgatcctctt aatttcttac     1320

ggtattcgcc gactgataaa gaaaagccca tctgatgtaa aacctctccc ctcacctgac     1380

acagacgtgc ctttaagttc tgttgaaata gaaaatccag agacaagtga tcaa           1434


<210>  48
<211>  205
<212>  PRT
<213>  Artificial

<220>
<223>  Extracellular 4-1BBL polypeptide

<400>  48

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            20                  25                  30          


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        35                  40                  45              


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    50                  55                  60                  


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
65                  70                  75                  80  


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                85                  90                  95      


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            100                 105                 110         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        115                 120                 125             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    130                 135                 140                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
145                 150                 155                 160 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                165                 170                 175     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            180                 185                 190         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200                 205 


<210>  49
<211>  615
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence encoding SEQ ID NO: 48 (extracellular 
       4-1BBL)

<400>  49
gcctgcccct gggccgtgtc cggggctcgc gcctcgcccg gctccgcggc cagcccgaga       60

ctccgcgagg gtcccgagct ttcgcccgac gatcccgccg gcctcttgga cctgcggcag      120

ggcatgtttg cgcagctggt ggcccaaaat gttctgctga tcgatgggcc cctgagctgg      180

tacagtgacc caggcctggc aggcgtgtcc ctgacggggg gcctgagcta caaagaggac      240

acgaaggagc tggtggtggc caaggctgga gtctactatg tcttctttca actagagctg      300

cggcgcgtgg tggccggcga gggctcaggc tccgtttcac ttgcgctgca cctgcagcca      360

ctgcgctctg ctgctggggc cgccgccctg gctttgaccg tggacctgcc acccgcctcc      420

tccgaggctc ggaactcggc cttcggtttc cagggccgct tgctgcacct gagtgccggc      480

cagcgcctgg gcgtccatct tcacactgag gccagggcac gccatgcctg gcagcttacc      540

cagggcgcca cagtcttggg actcttccgg gtgacccccg aaatcccagc cggactccct      600

tcaccgaggt cggaa                                                       615


<210>  50
<211>  381
<212>  PRT
<213>  Artificial

<220>
<223>  4-1BBL construct

<400>  50

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro 
            20                  25                  30          


Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro 
        35                  40                  45              


Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
    50                  55                  60                  


Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
65                  70                  75                  80  


Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
                85                  90                  95      


Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr 
            100                 105                 110         


Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
        115                 120                 125             


Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 
    130                 135                 140                 


Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser 
145                 150                 155                 160 


Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
                165                 170                 175     


Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
            180                 185                 190         


Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
        195                 200                 205             


Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
    210                 215                 220                 


Gly Gly Ser Gly Gly Ser Gly Gly Gly Pro Glu Asp Glu Pro Gly Ser 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Thr Thr Glu Val 
                245                 250                 255     


Ala Met His Thr Ser Thr Ser Ser Ser Val Thr Lys Ser Tyr Ile Ser 
            260                 265                 270         


Ser Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr Ala Ala Thr Pro 
        275                 280                 285             


Arg Ala His Glu Val Ser Glu Ile Ser Val Arg Thr Val Tyr Pro Pro 
    290                 295                 300                 


Glu Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His His Phe Ser Glu 
305                 310                 315                 320 


Pro Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly Val Ile Gly 
                325                 330                 335     


Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Leu Ile Lys Lys Ser 
            340                 345                 350         


Pro Ser Asp Val Lys Pro Leu Pro Ser Pro Asp Thr Asp Val Pro Leu 
        355                 360                 365             


Ser Ser Val Glu Ile Glu Asn Pro Glu Thr Ser Asp Gln 
    370                 375                 380     


<210>  51
<211>  1143
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence encoding SEQ ID NO: 50 (4-1BBL construct)

<400>  51
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagcagcc       60

tgcccctggg ccgtgtccgg ggctcgcgcc tcgcccggct ccgcggccag cccgagactc      120

cgcgagggtc ccgagctttc gcccgacgat cccgccggcc tcttggacct gcggcagggc      180

atgtttgcgc agctggtggc ccaaaatgtt ctgctgatcg atgggcccct gagctggtac      240

agtgacccag gcctggcagg cgtgtccctg acggggggcc tgagctacaa agaggacacg      300

aaggagctgg tggtggccaa ggctggagtc tactatgtct tctttcaact agagctgcgg      360

cgcgtggtgg ccggcgaggg ctcaggctcc gtttcacttg cgctgcacct gcagccactg      420

cgctctgctg ctggggccgc cgccctggct ttgaccgtgg acctgccacc cgcctcctcc      480

gaggctcgga actcggcctt cggtttccag ggccgcttgc tgcacctgag tgccggccag      540

cgcctgggcg tccatcttca cactgaggcc agggcacgcc atgcctggca gcttacccag      600

ggcgccacag tcttgggact cttccgggtg acccccgaaa tcccagccgg actcccttca      660

ccgaggtcgg aaggaggatc tggcgggtct ggaggcggcc ccgaggacga gcccggcagc      720

ggcagcggcg gagggtctgg aggcggttcc ttaagtacca ctgaggtggc aatgcacact      780

tcaacctctt cttcagtcac aaagagttac atctcatcac agacaaatga tacgcacaaa      840

cgggacacat atgcagccac tcctagagct catgaagttt cagaaatttc tgttagaact      900

gtttaccctc cagaagagga aaccggagaa agggtacaac ttgcccatca tttctctgaa      960

ccagagataa cactcattat ttttggggtg atggctggtg ttattggaac gatcctctta     1020

atttcttacg gtattcgccg actgataaag aaaagcccat ctgatgtaaa acctctcccc     1080

tcacctgaca cagacgtgcc tttaagttct gttgaaatag aaaatccaga gacaagtgat     1140

caa                                                                   1143


<210>  52
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  4-1BBL linker

<400>  52

Gly Gly Ser Gly Gly Ser Gly Gly Gly Pro Glu Asp Glu Pro Gly Ser 
1               5                   10                  15      


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25      


<210>  53
<211>  78
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence encoding SEQ ID NO: 52

<400>  53
ggaggatctg gcgggtctgg aggcggcccc gaggacgagc ccggcagcgg cagcggcgga       60

gggtctggag gcggttcc                                                     78


<210>  54
<211>  150
<212>  PRT
<213>  Artificial

<220>
<223>  Full Length GPA amino acid

<400>  54

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Ala Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His 
        35                  40                  45              


Lys Arg Asp Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu 
    50                  55                  60                  


Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg 
65                  70                  75                  80  


Val Gln Leu Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile 
                85                  90                  95      


Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr 
            100                 105                 110         


Gly Ile Arg Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu 
        115                 120                 125             


Pro Ser Pro Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn 
    130                 135                 140                 


Pro Glu Thr Ser Asp Gln 
145                 150 


<210>  55
<211>  78
<212>  PRT
<213>  Artificial

<220>
<223>  SMIM1 polypeptide

<400>  55

Met Gln Pro Gln Glu Ser His Val His Tyr Ser Arg Trp Glu Asp Gly 
1               5                   10                  15      


Ser Arg Asp Gly Val Ser Leu Gly Ala Val Ser Ser Thr Glu Glu Ala 
            20                  25                  30          


Ser Arg Cys Arg Arg Ile Ser Gln Arg Leu Cys Thr Gly Lys Leu Gly 
        35                  40                  45              


Ile Ala Met Lys Val Leu Gly Gly Val Ala Leu Phe Trp Ile Ile Phe 
    50                  55                  60                  


Ile Leu Gly Tyr Leu Thr Gly Tyr Tyr Val His Lys Cys Lys 
65                  70                  75              


<210>  56
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  G4S linker

<400>  56

Gly Gly Gly Gly Ser 
1               5   


<210>  57
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Linker-HA-linker

<400>  57

Gly Gly Ser Gly Gly Ser Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr 
1               5                   10                  15      


Ala Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25  


<210>  58
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  58

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Glu Asp Glu Asp Glu Asp 
1               5                   10                  15      


Glu Asp Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            20                  25              


<210>  59
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  59

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  60
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  60

Gly Ser Gly Ser Gly Ser Gly Ser Glu Asp Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser 
        


<210>  61
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  61

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser 
        


<210>  62
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  62

Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  63
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  63

Ser Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Ser Pro Ala 
            20                  25      


<210>  64
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  64

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  


<210>  65
<211>  58
<212>  PRT
<213>  Artificial

<220>
<223>  Snorkel linker

<400>  65

Ser Gly Arg Gly Ala Ser Ser Gly Ser Ser Gly Ser Gly Ser Gln Lys 
1               5                   10                  15      


Lys Pro Arg Tyr Glu Ile Arg Trp Lys Val Val Val Ile Ser Ala Ile 
            20                  25                  30          


Leu Ala Leu Val Val Leu Thr Val Ile Ser Leu Ile Ile Leu Ile Met 
        35                  40                  45              


Leu Trp Gly Ser Gly Met Gln Ser Pro Ala 
    50                  55              


<210>  66
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Ig heavy chain V region 3 signal sequence

<400>  66

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  67
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  light chain leader

<400>  67

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys 
            20  


<210>  68
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid linker

<400>  68

Ala Gly Ser Thr
1