                         SEQUENCE LISTING

<110>  Emory University
       Children's Healthcare of Atlanta, Inc.
       Henry, Curtis J.
       Raikar, Sunil S.
       Rafiq, Sarwish
 
<120>  Interleukin-37, Chimeric Antigen Receptors, Nucleic Acids, and 
       Vectors Encoding the Same and Uses in Cancer Therapies

<130>  21009 PCT

<150>  US 63/135,218
<151>  2021-01-08

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  1
gaggtgaaac tgcaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccgtc       60

acatgcactg tctcaggggt ctcattaccc gactatggtg taagctggat tcgccagcct      120

ccacgaaagg gtctggagtg gctgggagta atatggggta gtgaaaccac atactataat      180

tcagctctca aatccagact gaccatcatc aaggacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatttact actgtgccaa acattattac      300

tacggtggta gctatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  2
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  2

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  3
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggactaagt tggaaataac acgggctgat gctgcaccaa ctgtatccat cttcccacca      360

tccagtaat                                                              369


<210>  4
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  4

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Asn 
        115                 120             


<210>  5
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  5
ggcgggggag gatcaggtgg tggcggtagc ggtggaggtg gaagt                       45


<210>  6
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  6

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  7
<211>  774
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  7
gaggtgaaac tgcaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccgtc       60

acatgcactg tctcaggggt ctcattaccc gactatggtg taagctggat tcgccagcct      120

ccacgaaagg gtctggagtg gctgggagta atatggggta gtgaaaccac atactataat      180

tcagctctca aatccagact gaccatcatc aaggacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatttact actgtgccaa acattattac      300

tacggtggta gctatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360

ggcgggggag gatcaggtgg tggcggtagc ggtggaggtg gaagtgacat ccagatgaca      420

cagactacat cctccctgtc tgcctctctg ggagacagag tcaccatcag ttgcagggca      480

agtcaggaca ttagtaaata tttaaattgg tatcagcaga aaccagatgg aactgttaaa      540

ctcctgatct accatacatc aagattacac tcaggagtcc catcaaggtt cagtggcagt      600

gggtctggaa cagattattc tctcaccatt agcaacctgg agcaagaaga tattgccact      660

tacttttgcc aacagggtaa tacgcttccg tacacgttcg gaggggggac taagttggaa      720

ataacacggg ctgatgctgc accaactgta tccatcttcc caccatccag taat            774


<210>  8
<211>  258
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  8

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
                165                 170                 175     


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Thr Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser 
                245                 250                 255     


Ser Asn 
        


<210>  9
<211>  774
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  9
gaggtcaagc tccaagaatc tgggcctggt ttggtcgcgc cctctcagtc tttgtccgtc       60

acttgtactg tttccggcgt ttctctgccc gattacggag tctcttggat acggcagccc      120

ccacgaaagg ggttggagtg gttgggcgtt atatggggat cagaaacaac gtattacaac      180

tccgcgctca agagcagact tactattata aaggataaca gtaaatcaca ggtgttcctg      240

aaaatgaact ctttgcaaac cgatgatacg gcgatctact attgtgcgaa gcactattac      300

tacggtggta gctacgcgat ggactattgg ggccaaggga cgtctgtcac agtatcatct      360

ggtggaggtg ggagtggagg aggcggcagt ggaggcgggg ggagtgacat ccagatgacg      420

cagacgactt cttcactctc tgcatctttg ggagatcggg tgactatcag ttgcagggcg      480

tcccaggaca tatcaaagta ccttaactgg taccagcaga aacccgatgg gacagtaaaa      540

cttcttatat atcatacttc tcggctgcat tccggtgtgc catctaggtt ttcaggttct      600

ggctctggaa ccgactactc cttgacgatt tctaacctcg aacaagagga catagctacc      660

tatttttgtc agcagggaaa cactctcccg tacacgtttg gagggggaac taaactggag      720

atcacgcggg ctgacgcggc tccaactgtg agtatcttcc caccgtcctc aaat            774


<210>  10
<211>  258
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  10

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
                165                 170                 175     


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Thr Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser 
                245                 250                 255     


Ser Asn 
        


<210>  11
<211>  6
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  11
gctagc                                                                   6


<210>  12
<211>  138
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  12
accactaccc cggcccctag gccccctact ccagcgccaa ctatagcatc acagcctttg       60

agcttgaggc ccgaagcttg cagaccggcg gcaggggggg ctgtgcatac aaggggcctc      120

gactttgcct gcgacatc                                                    138


<210>  13
<211>  46
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  13

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      


<210>  14
<211>  618
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  14
gataatgaga agagcaatgg aaccattatc catgtgaaag ggaaacacct ttgtccaagt       60

cccctatttc ccggaccttc taagcccttt tgggtgctgg tggtggttgg tggagtcctg      120

gcttgctata gcttgctagt aacagtggcc tttattattt tctgggtgag gagtaagagg      180

agcaggctcc tgcacagtga ctacatgaac atgactccca ggaggcctgg gccaacccgc      240

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc cagcaggagc      300

gcagacgctc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga      360

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggaggc      420

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg      480

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat      540

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag      600

gccctgcctc ctcgctga                                                    618


<210>  15
<211>  205
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  15

Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
1               5                   10                  15      


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
            20                  25                  30          


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
        35                  40                  45              


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
    50                  55                  60                  


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
65                  70                  75                  80  


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
                85                  90                  95      


Ser Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
            100                 105                 110         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        115                 120                 125             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
    130                 135                 140                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
145                 150                 155                 160 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                165                 170                 175     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            180                 185                 190         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        195                 200                 205 


<210>  16
<211>  1605
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  16
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

ggcgcgcctg aggtcaagct ccaagaatct gggcctggtt tggtcgcgcc ctctcagtct      120

ttgtccgtca cttgtactgt ttccggcgtt tctctgcccg attacggagt ctcttggata      180

cggcagcccc cacgaaaggg gttggagtgg ttgggcgtta tatggggatc agaaacaacg      240

tattacaact ccgcgctcaa gagcagactt actattataa aggataacag taaatcacag      300

gtgttcctga aaatgaactc tttgcaaacc gatgatacgg cgatctacta ttgtgcgaag      360

cactattact acggtggtag ctacgcgatg gactattggg gccaagggac gtctgtcaca      420

gtatcatctg gtggaggtgg gagtggagga ggcggcagtg gaggcggggg gagtgacatc      480

cagatgacgc agacgacttc ttcactctct gcatctttgg gagatcgggt gactatcagt      540

tgcagggcgt cccaggacat atcaaagtac cttaactggt accagcagaa acccgatggg      600

acagtaaaac ttcttatata tcatacttct cggctgcatt ccggtgtgcc atctaggttt      660

tcaggttctg gctctggaac cgactactcc ttgacgattt ctaacctcga acaagaggac      720

atagctacct atttttgtca gcagggaaac actctcccgt acacgtttgg agggggaact      780

aaactggaga tcacgcgggc tgacgcggct ccaactgtga gtatcttccc accgtcctca      840

aatgctagca ccactacccc ggcccctagg ccccctactc cagcgccaac tatagcatca      900

cagcctttga gcttgaggcc cgaagcttgc agaccggcgg cagggggggc tgtgcataca      960

aggggcctcg actttgcctg cgacatcgat aatgagaaga gcaatggaac cattatccat     1020

gtgaaaggga aacacctttg tccaagtccc ctatttcccg gaccttctaa gcccttttgg     1080

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttt     1140

attattttct gggtgaggag taagaggagc aggctcctgc acagtgacta catgaacatg     1200

actcccagga ggcctgggcc aacccgcaag cattaccagc cctatgcccc accacgcgac     1260

ttcgcagcct atcgctccag caggagcgca gacgctcccg cgtaccagca gggccagaac     1320

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1380

cgtggccggg accctgagat gggaggcaag ccgagaagga agaaccctca ggaaggcctg     1440

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1500

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1560

gacacctacg acgcccttca catgcaggcc ctgcctcctc gctga                     1605


<210>  17
<211>  534
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  17

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ala Pro Glu Val Lys Leu Gln Glu Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
        35                  40                  45              


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
    50                  55                  60                  


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
65                  70                  75                  80  


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
                85                  90                  95      


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            100                 105                 110         


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
        115                 120                 125             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His 
        195                 200                 205             


Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp 
225                 230                 235                 240 


Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Ile Thr Arg Ala Asp Ala Ala Pro Thr 
            260                 265                 270         


Val Ser Ile Phe Pro Pro Ser Ser Asn Ala Ser Thr Thr Thr Pro Ala 
        275                 280                 285             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    290                 295                 300                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
305                 310                 315                 320 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Asp Asn Glu Lys Ser Asn Gly 
                325                 330                 335     


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
            340                 345                 350         


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
        355                 360                 365             


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
    370                 375                 380                 


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
385                 390                 395                 400 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                405                 410                 415     


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Ser Arg Ser Ala Asp Ala 
            420                 425                 430         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        435                 440                 445             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    450                 455                 460                 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
465                 470                 475                 480 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                485                 490                 495     


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            500                 505                 510         


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        515                 520                 525             


Gln Ala Leu Pro Pro Arg 
    530                 


<210>  18
<211>  218
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  18

Met Ser Phe Val Gly Glu Asn Ser Gly Val Lys Met Gly Ser Glu Asp 
1               5                   10                  15      


Trp Glu Lys Asp Glu Pro Gln Cys Cys Leu Glu Asp Pro Ala Gly Ser 
            20                  25                  30          


Pro Leu Glu Pro Gly Pro Ser Leu Pro Thr Met Asn Phe Val His Thr 
        35                  40                  45              


Ser Pro Lys Val Lys Asn Leu Asn Pro Lys Lys Phe Ser Ile His Asp 
    50                  55                  60                  


Gln Asp His Lys Val Leu Val Leu Asp Ser Gly Asn Leu Ile Ala Val 
65                  70                  75                  80  


Pro Asp Lys Asn Tyr Ile Arg Pro Glu Ile Phe Phe Ala Leu Ala Ser 
                85                  90                  95      


Ser Leu Ser Ser Ala Ser Ala Glu Lys Gly Ser Pro Ile Leu Leu Gly 
            100                 105                 110         


Val Ser Lys Gly Glu Phe Cys Leu Tyr Cys Asp Lys Asp Lys Gly Gln 
        115                 120                 125             


Ser His Pro Ser Leu Gln Leu Lys Lys Glu Lys Leu Met Lys Leu Ala 
    130                 135                 140                 


Ala Gln Lys Glu Ser Ala Arg Arg Pro Phe Ile Phe Tyr Arg Ala Gln 
145                 150                 155                 160 


Val Gly Ser Trp Asn Met Leu Glu Ser Ala Ala His Pro Gly Trp Phe 
                165                 170                 175     


Ile Cys Thr Ser Cys Asn Cys Asn Glu Pro Val Gly Val Thr Asp Lys 
            180                 185                 190         


Phe Glu Asn Arg Lys His Ile Glu Phe Ser Phe Gln Pro Val Cys Lys 
        195                 200                 205             


Ala Glu Met Ser Pro Ser Glu Val Ser Asp 
    210                 215             


<210>  19
<211>  653
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  19
tgagtttcgt cggcgaaaac agcggagtaa aaatgggaag cgaagattgg gaaaaggacg       60

agccgcaatg ctgtttggaa gatccggctg gctcccctct ggaaccaggt ccaagccttc      120

cgacgatgaa tttcgttcac accagtccga aagtaaagaa tcttaatccc aagaaatttt      180

caatccacga ccaagaccac aaggttctcg tacttgattc tggaaacctt atagcggtac      240

ccgataagaa ctatattagg ccagagattt tctttgcgtt ggcctcatca ctgagcagtg      300

cttctgctga aaaggggagc ccaatcctcc tgggcgtgtc aaagggcgag ttctgcctct      360

actgtgataa agataagggc cagtctcatc catcacttca gttgaaaaag gaaaaactga      420

tgaaactcgc ggctcagaaa gagagcgccc ggcggccatt tatattttat cgggcacaag      480

ttggtagctg gaatatgctc gagagcgcag cacatcccgg atggttcatt tgtacttcat      540

gtaattgcaa cgagcccgtg ggtgtcacgg ataaatttga gaaccggaaa catatcgaat      600

tttctttcca gcctgtatgc aaggcagaga tgtccccgag tgaggtaagt gac             653


<210>  20
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  20
ggatctggag caacaaactt ctcactactc aaacaagcag gtgacgtgga ggagaatccc       60

gggcct                                                                  66


<210>  21
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  21

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


