                         SEQUENCE LISTING

<110>  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
       Rosenbaum, Daniel M.
       Kober, Daniel
 
<120>  ENGINEERED STABLE ACE2 PROTEIN VARIANTS AS ANTIVIRAL

<130>  106546-712387 (UTSD 3793)

<150>  US 63/134,751
<151>  2021-01-07

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  805
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Full length Human ACE2

<400>  1

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  2
<211>  598
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Ectodomain of Human ACE2

<400>  2

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  3
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; WT ACE2

<400>  3

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu 
            20                  25                  30          


Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu 
        35                  40                  45              


Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn 
    50                  55                  60                  


Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser 
65                  70                  75                  80  


Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val 
                85                  90                  95      


Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser 
            100                 105                 110         


Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr 
        115                 120                 125             


Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys 
    130                 135                 140                 


Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp 
145                 150                 155                 160 


Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly 
                165                 170                 175     


Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu 
            180                 185                 190         


Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly 
        195                 200                 205             


Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln 
    210                 215                 220                 


Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr 
225                 230                 235                 240 


Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro 
                245                 250                 255     


Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp 
            260                 265                 270         


Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe 
        275                 280                 285             


Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala 
    290                 295                 300                 


Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser 
305                 310                 315                 320 


Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu 
                325                 330                 335     


Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp 
            340                 345                 350         


Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr 
        355                 360                 365             


Met Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr 
    370                 375                 380                 


Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn 
385                 390                 395                 400 


Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala 
                405                 410                 415     


Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln 
            420                 425                 430         


Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr 
        435                 440                 445             


Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp 
    450                 455                 460                 


Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp 
465                 470                 475                 480 


Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His 
                485                 490                 495     


Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp 
            500                 505                 510         


Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe 
        515                 520                 525             


Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys 
    530                 535                 540                 


Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met 
545                 550                 555                 560 


Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val 
                565                 570                 575     


Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu 
            580                 585                 590         


Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly 
        595                 600                 605             


Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg 
    610                 615                 620                 


Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp 
625                 630                 635                 640 


Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln 
                645                 650                 655     


Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp 
            660                 665                 670         


Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val 
        675                 680                 685             


Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu 
    690                 695                 700                 


Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu 
705                 710                 715                 720 


Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro 
                725                 730                 735     


Pro Asn Gln Pro Pro Val Ser Glu Asn Leu Tyr Phe Gln Gly Thr Gly 
            740                 745                 750         


His His His His His His His His His His 
        755                 760         


<210>  4
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; ACE2 T371X


<220>
<221>  misc_feature
<222>  (374)..(374)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu 
            20                  25                  30          


Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu 
        35                  40                  45              


Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn 
    50                  55                  60                  


Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser 
65                  70                  75                  80  


Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val 
                85                  90                  95      


Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser 
            100                 105                 110         


Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr 
        115                 120                 125             


Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys 
    130                 135                 140                 


Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp 
145                 150                 155                 160 


Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly 
                165                 170                 175     


Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu 
            180                 185                 190         


Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly 
        195                 200                 205             


Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln 
    210                 215                 220                 


Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr 
225                 230                 235                 240 


Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro 
                245                 250                 255     


Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp 
            260                 265                 270         


Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe 
        275                 280                 285             


Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala 
    290                 295                 300                 


Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser 
305                 310                 315                 320 


Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu 
                325                 330                 335     


Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp 
            340                 345                 350         


Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr 
        355                 360                 365             


Met Asp Asp Phe Leu Xaa Ala His His Glu Met Gly His Ile Gln Tyr 
    370                 375                 380                 


Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn 
385                 390                 395                 400 


Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala 
                405                 410                 415     


Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln 
            420                 425                 430         


Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr 
        435                 440                 445             


Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp 
    450                 455                 460                 


Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp 
465                 470                 475                 480 


Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His 
                485                 490                 495     


Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp 
            500                 505                 510         


Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe 
        515                 520                 525             


Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys 
    530                 535                 540                 


Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met 
545                 550                 555                 560 


Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val 
                565                 570                 575     


Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu 
            580                 585                 590         


Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly 
        595                 600                 605             


Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg 
    610                 615                 620                 


Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp 
625                 630                 635                 640 


Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln 
                645                 650                 655     


Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp 
            660                 665                 670         


Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val 
        675                 680                 685             


Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu 
    690                 695                 700                 


Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu 
705                 710                 715                 720 


Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro 
                725                 730                 735     


Pro Asn Gln Pro Pro Val Ser Glu Asn Leu Tyr Phe Gln Gly Thr Gly 
            740                 745                 750         


His His His His His His His His His His 
        755                 760         


<210>  5
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; N149X ACE2


<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu 
            20                  25                  30          


Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu 
        35                  40                  45              


Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn 
    50                  55                  60                  


Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser 
65                  70                  75                  80  


Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val 
                85                  90                  95      


Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser 
            100                 105                 110         


Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr 
        115                 120                 125             


Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys 
    130                 135                 140                 


Leu Leu Leu Glu Pro Gly Leu Xaa Glu Ile Met Ala Asn Ser Leu Asp 
145                 150                 155                 160 


Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly 
                165                 170                 175     


Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu 
            180                 185                 190         


Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly 
        195                 200                 205             


Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln 
    210                 215                 220                 


Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr 
225                 230                 235                 240 


Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro 
                245                 250                 255     


Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp 
            260                 265                 270         


Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe 
        275                 280                 285             


Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala 
    290                 295                 300                 


Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser 
305                 310                 315                 320 


Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu 
                325                 330                 335     


Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp 
            340                 345                 350         


Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr 
        355                 360                 365             


Met Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr 
    370                 375                 380                 


Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn 
385                 390                 395                 400 


Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala 
                405                 410                 415     


Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln 
            420                 425                 430         


Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr 
        435                 440                 445             


Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp 
    450                 455                 460                 


Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp 
465                 470                 475                 480 


Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His 
                485                 490                 495     


Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp 
            500                 505                 510         


Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe 
        515                 520                 525             


Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys 
    530                 535                 540                 


Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met 
545                 550                 555                 560 


Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val 
                565                 570                 575     


Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu 
            580                 585                 590         


Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly 
        595                 600                 605             


Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg 
    610                 615                 620                 


Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp 
625                 630                 635                 640 


Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln 
                645                 650                 655     


Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp 
            660                 665                 670         


Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val 
        675                 680                 685             


Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu 
    690                 695                 700                 


Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu 
705                 710                 715                 720 


Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro 
                725                 730                 735     


Pro Asn Gln Pro Pro Val Ser Glu Asn Leu Tyr Phe Gln Gly Thr Gly 
            740                 745                 750         


His His His His His His His His His His 
        755                 760         


<210>  6
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; F274X ACE2


<220>
<221>  misc_feature
<222>  (277)..(277)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu 
            20                  25                  30          


Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu 
        35                  40                  45              


Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn 
    50                  55                  60                  


Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser 
65                  70                  75                  80  


Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val 
                85                  90                  95      


Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser 
            100                 105                 110         


Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr 
        115                 120                 125             


Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys 
    130                 135                 140                 


Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp 
145                 150                 155                 160 


Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly 
                165                 170                 175     


Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu 
            180                 185                 190         


Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly 
        195                 200                 205             


Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln 
    210                 215                 220                 


Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr 
225                 230                 235                 240 


Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro 
                245                 250                 255     


Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp 
            260                 265                 270         


Met Trp Gly Arg Xaa Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe 
        275                 280                 285             


Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala 
    290                 295                 300                 


Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser 
305                 310                 315                 320 


Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu 
                325                 330                 335     


Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp 
            340                 345                 350         


Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr 
        355                 360                 365             


Met Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr 
    370                 375                 380                 


Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn 
385                 390                 395                 400 


Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala 
                405                 410                 415     


Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln 
            420                 425                 430         


Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr 
        435                 440                 445             


Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp 
    450                 455                 460                 


Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp 
465                 470                 475                 480 


Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His 
                485                 490                 495     


Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp 
            500                 505                 510         


Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe 
        515                 520                 525             


Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys 
    530                 535                 540                 


Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met 
545                 550                 555                 560 


Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val 
                565                 570                 575     


Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu 
            580                 585                 590         


Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly 
        595                 600                 605             


Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg 
    610                 615                 620                 


Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp 
625                 630                 635                 640 


Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln 
                645                 650                 655     


Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp 
            660                 665                 670         


Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val 
        675                 680                 685             


Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu 
    690                 695                 700                 


Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu 
705                 710                 715                 720 


Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro 
                725                 730                 735     


Pro Asn Gln Pro Pro Val Ser Glu Asn Leu Tyr Phe Gln Gly Thr Gly 
            740                 745                 750         


His His His His His His His His His His 
        755                 760         


<210>  7
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; H345X ACE2


<220>
<221>  misc_feature
<222>  (348)..(348)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu 
            20                  25                  30          


Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu 
        35                  40                  45              


Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn 
    50                  55                  60                  


Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser 
65                  70                  75                  80  


Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val 
                85                  90                  95      


Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser 
            100                 105                 110         


Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr 
        115                 120                 125             


Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys 
    130                 135                 140                 


Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp 
145                 150                 155                 160 


Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly 
                165                 170                 175     


Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu 
            180                 185                 190         


Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly 
        195                 200                 205             


Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln 
    210                 215                 220                 


Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr 
225                 230                 235                 240 


Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro 
                245                 250                 255     


Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp 
            260                 265                 270         


Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe 
        275                 280                 285             


Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala 
    290                 295                 300                 


Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser 
305                 310                 315                 320 


Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu 
                325                 330                 335     


Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys Xaa Pro Thr Ala Trp 
            340                 345                 350         


Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr 
        355                 360                 365             


Met Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr 
    370                 375                 380                 


Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn 
385                 390                 395                 400 


Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala 
                405                 410                 415     


Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln 
            420                 425                 430         


Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr 
        435                 440                 445             


Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp 
    450                 455                 460                 


Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp 
465                 470                 475                 480 


Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His 
                485                 490                 495     


Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp 
            500                 505                 510         


Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe 
        515                 520                 525             


Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys 
    530                 535                 540                 


Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met 
545                 550                 555                 560 


Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val 
                565                 570                 575     


Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu 
            580                 585                 590         


Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly 
        595                 600                 605             


Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg 
    610                 615                 620                 


Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp 
625                 630                 635                 640 


Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln 
                645                 650                 655     


Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp 
            660                 665                 670         


Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val 
        675                 680                 685             


Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu 
    690                 695                 700                 


Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu 
705                 710                 715                 720 


Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro 
                725                 730                 735     


Pro Asn Gln Pro Pro Val Ser Glu Asn Leu Tyr Phe Gln Gly Thr Gly 
            740                 745                 750         


His His His His His His His His His His 
        755                 760         


<210>  8
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; F504X ACE2


<220>
<221>  misc_feature
<222>  (507)..(507)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu 
            20                  25                  30          


Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu 
        35                  40                  45              


Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn 
    50                  55                  60                  


Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser 
65                  70                  75                  80  


Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val 
                85                  90                  95      


Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser 
            100                 105                 110         


Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr 
        115                 120                 125             


Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys 
    130                 135                 140                 


Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp 
145                 150                 155                 160 


Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly 
                165                 170                 175     


Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu 
            180                 185                 190         


Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly 
        195                 200                 205             


Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln 
    210                 215                 220                 


Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr 
225                 230                 235                 240 


Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro 
                245                 250                 255     


Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp 
            260                 265                 270         


Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe 
        275                 280                 285             


Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala 
    290                 295                 300                 


Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser 
305                 310                 315                 320 


Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu 
                325                 330                 335     


Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp 
            340                 345                 350         


Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr 
        355                 360                 365             


Met Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr 
    370                 375                 380                 


Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn 
385                 390                 395                 400 


Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala 
                405                 410                 415     


Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln 
            420                 425                 430         


Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr 
        435                 440                 445             


Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp 
    450                 455                 460                 


Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp 
465                 470                 475                 480 


Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His 
                485                 490                 495     


Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Xaa His Val Ser Asn Asp 
            500                 505                 510         


Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe 
        515                 520                 525             


Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys 
    530                 535                 540                 


Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met 
545                 550                 555                 560 


Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val 
                565                 570                 575     


Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu 
            580                 585                 590         


Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly 
        595                 600                 605             


Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg 
    610                 615                 620                 


Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp 
625                 630                 635                 640 


Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln 
                645                 650                 655     


Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp 
            660                 665                 670         


Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val 
        675                 680                 685             


Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu 
    690                 695                 700                 


Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu 
705                 710                 715                 720 


Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro 
                725                 730                 735     


Pro Asn Gln Pro Pro Val Ser Glu Asn Leu Tyr Phe Gln Gly Thr Gly 
            740                 745                 750         


His His His His His His His His His His 
        755                 760         


<210>  9
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; H505X ACE2


<220>
<221>  misc_feature
<222>  (508)..(508)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu 
            20                  25                  30          


Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu 
        35                  40                  45              


Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn 
    50                  55                  60                  


Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser 
65                  70                  75                  80  


Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val 
                85                  90                  95      


Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser 
            100                 105                 110         


Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr 
        115                 120                 125             


Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys 
    130                 135                 140                 


Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp 
145                 150                 155                 160 


Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly 
                165                 170                 175     


Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu 
            180                 185                 190         


Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly 
        195                 200                 205             


Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln 
    210                 215                 220                 


Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr 
225                 230                 235                 240 


Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro 
                245                 250                 255     


Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp 
            260                 265                 270         


Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe 
        275                 280                 285             


Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala 
    290                 295                 300                 


Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser 
305                 310                 315                 320 


Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu 
                325                 330                 335     


Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp 
            340                 345                 350         


Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr 
        355                 360                 365             


Met Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr 
    370                 375                 380                 


Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn 
385                 390                 395                 400 


Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala 
                405                 410                 415     


Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln 
            420                 425                 430         


Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr 
        435                 440                 445             


Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp 
    450                 455                 460                 


Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp 
465                 470                 475                 480 


Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His 
                485                 490                 495     


Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe Xaa Val Ser Asn Asp 
            500                 505                 510         


Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe 
        515                 520                 525             


Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys 
    530                 535                 540                 


Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met 
545                 550                 555                 560 


Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val 
                565                 570                 575     


Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu 
            580                 585                 590         


Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly 
        595                 600                 605             


Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg 
    610                 615                 620                 


Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp 
625                 630                 635                 640 


Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln 
                645                 650                 655     


Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp 
            660                 665                 670         


Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val 
        675                 680                 685             


Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu 
    690                 695                 700                 


Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu 
705                 710                 715                 720 


Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro 
                725                 730                 735     


Pro Asn Gln Pro Pro Val Ser Glu Asn Leu Tyr Phe Gln Gly Thr Gly 
            740                 745                 750         


His His His His His His His His His His 
        755                 760         


<210>  10
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; ACE2 T371W

<400>  10

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu 
            20                  25                  30          


Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu 
        35                  40                  45              


Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn 
    50                  55                  60                  


Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser 
65                  70                  75                  80  


Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val 
                85                  90                  95      


Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser 
            100                 105                 110         


Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr 
        115                 120                 125             


Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys 
    130                 135                 140                 


Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp 
145                 150                 155                 160 


Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly 
                165                 170                 175     


Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu 
            180                 185                 190         


Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly 
        195                 200                 205             


Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln 
    210                 215                 220                 


Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr 
225                 230                 235                 240 


Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro 
                245                 250                 255     


Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp 
            260                 265                 270         


Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe 
        275                 280                 285             


Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala 
    290                 295                 300                 


Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser 
305                 310                 315                 320 


Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu 
                325                 330                 335     


Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp 
            340                 345                 350         


Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr 
        355                 360                 365             


Met Asp Asp Phe Leu Trp Ala His His Glu Met Gly His Ile Gln Tyr 
    370                 375                 380                 


Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn 
385                 390                 395                 400 


Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala 
                405                 410                 415     


Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln 
            420                 425                 430         


Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr 
        435                 440                 445             


Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp 
    450                 455                 460                 


Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp 
465                 470                 475                 480 


Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His 
                485                 490                 495     


Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp 
            500                 505                 510         


Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe 
        515                 520                 525             


Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys 
    530                 535                 540                 


Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met 
545                 550                 555                 560 


Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val 
                565                 570                 575     


Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu 
            580                 585                 590         


Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly 
        595                 600                 605             


Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg 
    610                 615                 620                 


Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp 
625                 630                 635                 640 


Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln 
                645                 650                 655     


Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp 
            660                 665                 670         


Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val 
        675                 680                 685             


Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu 
    690                 695                 700                 


Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu 
705                 710                 715                 720 


Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro 
                725                 730                 735     


Pro Asn Gln Pro Pro Val Ser Glu Asn Leu Tyr Phe Gln Gly Thr Gly 
            740                 745                 750         


His His His His His His His His His His 
        755                 760         


<210>  11
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; WT ACE2

<400>  11
atgaaatttc tggtcaatgt agccctggta ttcatggtcg tctacatctc gtatatatat       60

gcctcgacaa tagaagaaca agctaagact tttctcgaca aatttaacca tgaagcagag      120

gacctcttct accagtcatc gttggcatcg tggaactaca acacgaatat aaccgaggaa      180

aacgttcaga atatgaacaa cgccggcgat aagtggagcg ccttccttaa ggagcaatct      240

acgctggccc agatgtatcc cttgcaggag attcaaaatc ttacggttaa gcttcagctg      300

caggccctgc agcaaaatgg ttcaagcgta ctcagtgaag ataaatctaa gagactgaat      360

acaattctca acaccatgag caccatttac tctacaggaa aggtgtgcaa ccccgataat      420

ccacaagagt gcctgttgct ggagcctggc ctcaatgaaa ttatggcaaa cagtcttgac      480

tacaatgaga ggctctgggc gtgggagtct tggaggagtg aggtgggaaa gcagctgcgc      540

ccactgtatg aagagtatgt agtccttaag aacgagatgg cgcgcgcaaa tcattatgag      600

gattatggag attactggcg tggcgactat gaagtgaatg gcgtcgacgg atacgattat      660

tcgcgcggcc aactcatcga ggatgtagag cacactttcg aagagataaa gcctttgtac      720

gagcaccttc acgcgtacgt tagggccaag cttatgaatg cttacccatc ttatattagc      780

cctatcggct gcctgcctgc gcatctgttg ggagatatgt ggggtcgctt ctggaccaac      840

ctctattctc ttactgtccc attcggccaa aagccaaata tcgacgtgac agatgccatg      900

gtcgatcaag catgggacgc ccaaaggata ttcaaggaag ccgaaaaatt ttttgttagt      960

gtcggcctcc ccaacatgac gcaaggtttc tgggagaatt ctatgctcac ggatccaggt     1020

aacgtgcaga aggccgtatg ccaccccaca gcctgggact tgggtaaagg agacttcagg     1080

attttgatgt gtaccaaagt taccatggat gattttctga ctgcacacca cgaaatgggc     1140

cacattcagt atgatatggc ttacgctgct caaccatttc ttcttcgcaa tggagccaac     1200

gagggatttc atgaagcagt aggtgaaata atgtcgctga gtgcggcaac accgaagcac     1260

cttaagtcca ttggactgct cagccccgac tttcaggaag ataacgagac ggagataaac     1320

ttcctgctca agcaggcact cacgatcgtg ggaacgttgc cttttacgta tatgcttgaa     1380

aagtggagat ggatggtgtt caaaggcgaa atacctaaag accagtggat gaaaaagtgg     1440

tgggaaatga agagagaaat agtcggagtc gtcgaacccg tgccgcatga tgaaacctac     1500

tgcgatcctg ccagcttgtt tcatgtgagt aatgattata gtttcatacg ctactatact     1560

cgcacgttgt accagtttca atttcaggag gccctgtgtc aagcggcaaa gcatgaggga     1620

ccgctgcaca agtgcgacat aagtaatagc actgaggctg gacaaaagct gtttaacatg     1680

ctgcgtctcg gaaagagtga gccttggact ctcgcactgg aaaatgtcgt tggcgcgaaa     1740

aacatgaatg tacgtccgct tctgaattac tttgagccat tgtttacatg gttgaaagat     1800

cagaataaaa atagttttgt gggctggtca acggattgga gcccttacgc tgatcaatct     1860

ataaaggtga gaatatccct taagagtgcg ttgggagata aggcatacga gtggaacgac     1920

aatgaaatgt acttgttccg ctcttcagta gcatacgcta tgaggcagta tttccttaaa     1980

gtaaaaaatc agatgatctt gtttggcgaa gaagatgtcc gcgttgctaa ccttaagcca     2040

agaatttcgt tcaacttttt tgttaccgca ccaaagaatg tctcagacat cataccccgc     2100

actgaagtag aaaaagcgat tagaatgtcg cgtagtcgta tcaacgacgc gtttaggctc     2160

aacgacaatt cgctggaatt cctgggaatt cagcccacat tgggccctcc aaaccagcct     2220

ccggtgtcgg agaatctcta cttccagggt accggtcatc accaccacca ccatcaccat     2280

catcattga                                                             2289


<210>  12
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; ACE2 T371X


<220>
<221>  misc_feature
<222>  (1120)..(1122)
<223>  n is a, c, g, t or u

<400>  12
atgaaatttc tggtcaatgt agccctggta ttcatggtcg tctacatctc gtatatatat       60

gcctcgacaa tagaagaaca agctaagact tttctcgaca aatttaacca tgaagcagag      120

gacctcttct accagtcatc gttggcatcg tggaactaca acacgaatat aaccgaggaa      180

aacgttcaga atatgaacaa cgccggcgat aagtggagcg ccttccttaa ggagcaatct      240

acgctggccc agatgtatcc cttgcaggag attcaaaatc ttacggttaa gcttcagctg      300

caggccctgc agcaaaatgg ttcaagcgta ctcagtgaag ataaatctaa gagactgaat      360

acaattctca acaccatgag caccatttac tctacaggaa aggtgtgcaa ccccgataat      420

ccacaagagt gcctgttgct ggagcctggc ctcaatgaaa ttatggcaaa cagtcttgac      480

tacaatgaga ggctctgggc gtgggagtct tggaggagtg aggtgggaaa gcagctgcgc      540

ccactgtatg aagagtatgt agtccttaag aacgagatgg cgcgcgcaaa tcattatgag      600

gattatggag attactggcg tggcgactat gaagtgaatg gcgtcgacgg atacgattat      660

tcgcgcggcc aactcatcga ggatgtagag cacactttcg aagagataaa gcctttgtac      720

gagcaccttc acgcgtacgt tagggccaag cttatgaatg cttacccatc ttatattagc      780

cctatcggct gcctgcctgc gcatctgttg ggagatatgt ggggtcgctt ctggaccaac      840

ctctattctc ttactgtccc attcggccaa aagccaaata tcgacgtgac agatgccatg      900

gtcgatcaag catgggacgc ccaaaggata ttcaaggaag ccgaaaaatt ttttgttagt      960

gtcggcctcc ccaacatgac gcaaggtttc tgggagaatt ctatgctcac ggatccaggt     1020

aacgtgcaga aggccgtatg ccaccccaca gcctgggact tgggtaaagg agacttcagg     1080

attttgatgt gtaccaaagt taccatggat gattttctgn nngcacacca cgaaatgggc     1140

cacattcagt atgatatggc ttacgctgct caaccatttc ttcttcgcaa tggagccaac     1200

gagggatttc atgaagcagt aggtgaaata atgtcgctga gtgcggcaac accgaagcac     1260

cttaagtcca ttggactgct cagccccgac tttcaggaag ataacgagac ggagataaac     1320

ttcctgctca agcaggcact cacgatcgtg ggaacgttgc cttttacgta tatgcttgaa     1380

aagtggagat ggatggtgtt caaaggcgaa atacctaaag accagtggat gaaaaagtgg     1440

tgggaaatga agagagaaat agtcggagtc gtcgaacccg tgccgcatga tgaaacctac     1500

tgcgatcctg ccagcttgtt tcatgtgagt aatgattata gtttcatacg ctactatact     1560

cgcacgttgt accagtttca atttcaggag gccctgtgtc aagcggcaaa gcatgaggga     1620

ccgctgcaca agtgcgacat aagtaatagc actgaggctg gacaaaagct gtttaacatg     1680

ctgcgtctcg gaaagagtga gccttggact ctcgcactgg aaaatgtcgt tggcgcgaaa     1740

aacatgaatg tacgtccgct tctgaattac tttgagccat tgtttacatg gttgaaagat     1800

cagaataaaa atagttttgt gggctggtca acggattgga gcccttacgc tgatcaatct     1860

ataaaggtga gaatatccct taagagtgcg ttgggagata aggcatacga gtggaacgac     1920

aatgaaatgt acttgttccg ctcttcagta gcatacgcta tgaggcagta tttccttaaa     1980

gtaaaaaatc agatgatctt gtttggcgaa gaagatgtcc gcgttgctaa ccttaagcca     2040

agaatttcgt tcaacttttt tgttaccgca ccaaagaatg tctcagacat cataccccgc     2100

actgaagtag aaaaagcgat tagaatgtcg cgtagtcgta tcaacgacgc gtttaggctc     2160

aacgacaatt cgctggaatt cctgggaatt cagcccacat tgggccctcc aaaccagcct     2220

ccggtgtcgg agaatctcta cttccagggt accggtcatc accaccacca ccatcaccat     2280

catcattga                                                             2289


<210>  13
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; ACE2 N149X


<220>
<221>  misc_feature
<222>  (454)..(456)
<223>  n is a, c, g, t or u

<400>  13
atgaaatttc tggtcaatgt agccctggta ttcatggtcg tctacatctc gtatatatat       60

gcctcgacaa tagaagaaca agctaagact tttctcgaca aatttaacca tgaagcagag      120

gacctcttct accagtcatc gttggcatcg tggaactaca acacgaatat aaccgaggaa      180

aacgttcaga atatgaacaa cgccggcgat aagtggagcg ccttccttaa ggagcaatct      240

acgctggccc agatgtatcc cttgcaggag attcaaaatc ttacggttaa gcttcagctg      300

caggccctgc agcaaaatgg ttcaagcgta ctcagtgaag ataaatctaa gagactgaat      360

acaattctca acaccatgag caccatttac tctacaggaa aggtgtgcaa ccccgataat      420

ccacaagagt gcctgttgct ggagcctggc ctcnnngaaa ttatggcaaa cagtcttgac      480

tacaatgaga ggctctgggc gtgggagtct tggaggagtg aggtgggaaa gcagctgcgc      540

ccactgtatg aagagtatgt agtccttaag aacgagatgg cgcgcgcaaa tcattatgag      600

gattatggag attactggcg tggcgactat gaagtgaatg gcgtcgacgg atacgattat      660

tcgcgcggcc aactcatcga ggatgtagag cacactttcg aagagataaa gcctttgtac      720

gagcaccttc acgcgtacgt tagggccaag cttatgaatg cttacccatc ttatattagc      780

cctatcggct gcctgcctgc gcatctgttg ggagatatgt ggggtcgctt ctggaccaac      840

ctctattctc ttactgtccc attcggccaa aagccaaata tcgacgtgac agatgccatg      900

gtcgatcaag catgggacgc ccaaaggata ttcaaggaag ccgaaaaatt ttttgttagt      960

gtcggcctcc ccaacatgac gcaaggtttc tgggagaatt ctatgctcac ggatccaggt     1020

aacgtgcaga aggccgtatg ccaccccaca gcctgggact tgggtaaagg agacttcagg     1080

attttgatgt gtaccaaagt taccatggat gattttctga ctgcacacca cgaaatgggc     1140

cacattcagt atgatatggc ttacgctgct caaccatttc ttcttcgcaa tggagccaac     1200

gagggatttc atgaagcagt aggtgaaata atgtcgctga gtgcggcaac accgaagcac     1260

cttaagtcca ttggactgct cagccccgac tttcaggaag ataacgagac ggagataaac     1320

ttcctgctca agcaggcact cacgatcgtg ggaacgttgc cttttacgta tatgcttgaa     1380

aagtggagat ggatggtgtt caaaggcgaa atacctaaag accagtggat gaaaaagtgg     1440

tgggaaatga agagagaaat agtcggagtc gtcgaacccg tgccgcatga tgaaacctac     1500

tgcgatcctg ccagcttgtt tcatgtgagt aatgattata gtttcatacg ctactatact     1560

cgcacgttgt accagtttca atttcaggag gccctgtgtc aagcggcaaa gcatgaggga     1620

ccgctgcaca agtgcgacat aagtaatagc actgaggctg gacaaaagct gtttaacatg     1680

ctgcgtctcg gaaagagtga gccttggact ctcgcactgg aaaatgtcgt tggcgcgaaa     1740

aacatgaatg tacgtccgct tctgaattac tttgagccat tgtttacatg gttgaaagat     1800

cagaataaaa atagttttgt gggctggtca acggattgga gcccttacgc tgatcaatct     1860

ataaaggtga gaatatccct taagagtgcg ttgggagata aggcatacga gtggaacgac     1920

aatgaaatgt acttgttccg ctcttcagta gcatacgcta tgaggcagta tttccttaaa     1980

gtaaaaaatc agatgatctt gtttggcgaa gaagatgtcc gcgttgctaa ccttaagcca     2040

agaatttcgt tcaacttttt tgttaccgca ccaaagaatg tctcagacat cataccccgc     2100

actgaagtag aaaaagcgat tagaatgtcg cgtagtcgta tcaacgacgc gtttaggctc     2160

aacgacaatt cgctggaatt cctgggaatt cagcccacat tgggccctcc aaaccagcct     2220

ccggtgtcgg agaatctcta cttccagggt accggtcatc accaccacca ccatcaccat     2280

catcattga                                                             2289


<210>  14
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; ACE2 F274X


<220>
<221>  misc_feature
<222>  (829)..(831)
<223>  n is a, c, g, t or u

<400>  14
atgaaatttc tggtcaatgt agccctggta ttcatggtcg tctacatctc gtatatatat       60

gcctcgacaa tagaagaaca agctaagact tttctcgaca aatttaacca tgaagcagag      120

gacctcttct accagtcatc gttggcatcg tggaactaca acacgaatat aaccgaggaa      180

aacgttcaga atatgaacaa cgccggcgat aagtggagcg ccttccttaa ggagcaatct      240

acgctggccc agatgtatcc cttgcaggag attcaaaatc ttacggttaa gcttcagctg      300

caggccctgc agcaaaatgg ttcaagcgta ctcagtgaag ataaatctaa gagactgaat      360

acaattctca acaccatgag caccatttac tctacaggaa aggtgtgcaa ccccgataat      420

ccacaagagt gcctgttgct ggagcctggc ctcaatgaaa ttatggcaaa cagtcttgac      480

tacaatgaga ggctctgggc gtgggagtct tggaggagtg aggtgggaaa gcagctgcgc      540

ccactgtatg aagagtatgt agtccttaag aacgagatgg cgcgcgcaaa tcattatgag      600

gattatggag attactggcg tggcgactat gaagtgaatg gcgtcgacgg atacgattat      660

tcgcgcggcc aactcatcga ggatgtagag cacactttcg aagagataaa gcctttgtac      720

gagcaccttc acgcgtacgt tagggccaag cttatgaatg cttacccatc ttatattagc      780

cctatcggct gcctgcctgc gcatctgttg ggagatatgt ggggtcgcnn ntggaccaac      840

ctctattctc ttactgtccc attcggccaa aagccaaata tcgacgtgac agatgccatg      900

gtcgatcaag catgggacgc ccaaaggata ttcaaggaag ccgaaaaatt ttttgttagt      960

gtcggcctcc ccaacatgac gcaaggtttc tgggagaatt ctatgctcac ggatccaggt     1020

aacgtgcaga aggccgtatg ccaccccaca gcctgggact tgggtaaagg agacttcagg     1080

attttgatgt gtaccaaagt taccatggat gattttctga ctgcacacca cgaaatgggc     1140

cacattcagt atgatatggc ttacgctgct caaccatttc ttcttcgcaa tggagccaac     1200

gagggatttc atgaagcagt aggtgaaata atgtcgctga gtgcggcaac accgaagcac     1260

cttaagtcca ttggactgct cagccccgac tttcaggaag ataacgagac ggagataaac     1320

ttcctgctca agcaggcact cacgatcgtg ggaacgttgc cttttacgta tatgcttgaa     1380

aagtggagat ggatggtgtt caaaggcgaa atacctaaag accagtggat gaaaaagtgg     1440

tgggaaatga agagagaaat agtcggagtc gtcgaacccg tgccgcatga tgaaacctac     1500

tgcgatcctg ccagcttgtt tcatgtgagt aatgattata gtttcatacg ctactatact     1560

cgcacgttgt accagtttca atttcaggag gccctgtgtc aagcggcaaa gcatgaggga     1620

ccgctgcaca agtgcgacat aagtaatagc actgaggctg gacaaaagct gtttaacatg     1680

ctgcgtctcg gaaagagtga gccttggact ctcgcactgg aaaatgtcgt tggcgcgaaa     1740

aacatgaatg tacgtccgct tctgaattac tttgagccat tgtttacatg gttgaaagat     1800

cagaataaaa atagttttgt gggctggtca acggattgga gcccttacgc tgatcaatct     1860

ataaaggtga gaatatccct taagagtgcg ttgggagata aggcatacga gtggaacgac     1920

aatgaaatgt acttgttccg ctcttcagta gcatacgcta tgaggcagta tttccttaaa     1980

gtaaaaaatc agatgatctt gtttggcgaa gaagatgtcc gcgttgctaa ccttaagcca     2040

agaatttcgt tcaacttttt tgttaccgca ccaaagaatg tctcagacat cataccccgc     2100

actgaagtag aaaaagcgat tagaatgtcg cgtagtcgta tcaacgacgc gtttaggctc     2160

aacgacaatt cgctggaatt cctgggaatt cagcccacat tgggccctcc aaaccagcct     2220

ccggtgtcgg agaatctcta cttccagggt accggtcatc accaccacca ccatcaccat     2280

catcattga                                                             2289


<210>  15
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; ACE2 H345X


<220>
<221>  misc_feature
<222>  (1042)..(1044)
<223>  n is a, c, g, t or u

<400>  15
atgaaatttc tggtcaatgt agccctggta ttcatggtcg tctacatctc gtatatatat       60

gcctcgacaa tagaagaaca agctaagact tttctcgaca aatttaacca tgaagcagag      120

gacctcttct accagtcatc gttggcatcg tggaactaca acacgaatat aaccgaggaa      180

aacgttcaga atatgaacaa cgccggcgat aagtggagcg ccttccttaa ggagcaatct      240

acgctggccc agatgtatcc cttgcaggag attcaaaatc ttacggttaa gcttcagctg      300

caggccctgc agcaaaatgg ttcaagcgta ctcagtgaag ataaatctaa gagactgaat      360

acaattctca acaccatgag caccatttac tctacaggaa aggtgtgcaa ccccgataat      420

ccacaagagt gcctgttgct ggagcctggc ctcaatgaaa ttatggcaaa cagtcttgac      480

tacaatgaga ggctctgggc gtgggagtct tggaggagtg aggtgggaaa gcagctgcgc      540

ccactgtatg aagagtatgt agtccttaag aacgagatgg cgcgcgcaaa tcattatgag      600

gattatggag attactggcg tggcgactat gaagtgaatg gcgtcgacgg atacgattat      660

tcgcgcggcc aactcatcga ggatgtagag cacactttcg aagagataaa gcctttgtac      720

gagcaccttc acgcgtacgt tagggccaag cttatgaatg cttacccatc ttatattagc      780

cctatcggct gcctgcctgc gcatctgttg ggagatatgt ggggtcgctt ctggaccaac      840

ctctattctc ttactgtccc attcggccaa aagccaaata tcgacgtgac agatgccatg      900

gtcgatcaag catgggacgc ccaaaggata ttcaaggaag ccgaaaaatt ttttgttagt      960

gtcggcctcc ccaacatgac gcaaggtttc tgggagaatt ctatgctcac ggatccaggt     1020

aacgtgcaga aggccgtatg cnnncccaca gcctgggact tgggtaaagg agacttcagg     1080

attttgatgt gtaccaaagt taccatggat gattttctga ctgcacacca cgaaatgggc     1140

cacattcagt atgatatggc ttacgctgct caaccatttc ttcttcgcaa tggagccaac     1200

gagggatttc atgaagcagt aggtgaaata atgtcgctga gtgcggcaac accgaagcac     1260

cttaagtcca ttggactgct cagccccgac tttcaggaag ataacgagac ggagataaac     1320

ttcctgctca agcaggcact cacgatcgtg ggaacgttgc cttttacgta tatgcttgaa     1380

aagtggagat ggatggtgtt caaaggcgaa atacctaaag accagtggat gaaaaagtgg     1440

tgggaaatga agagagaaat agtcggagtc gtcgaacccg tgccgcatga tgaaacctac     1500

tgcgatcctg ccagcttgtt tcatgtgagt aatgattata gtttcatacg ctactatact     1560

cgcacgttgt accagtttca atttcaggag gccctgtgtc aagcggcaaa gcatgaggga     1620

ccgctgcaca agtgcgacat aagtaatagc actgaggctg gacaaaagct gtttaacatg     1680

ctgcgtctcg gaaagagtga gccttggact ctcgcactgg aaaatgtcgt tggcgcgaaa     1740

aacatgaatg tacgtccgct tctgaattac tttgagccat tgtttacatg gttgaaagat     1800

cagaataaaa atagttttgt gggctggtca acggattgga gcccttacgc tgatcaatct     1860

ataaaggtga gaatatccct taagagtgcg ttgggagata aggcatacga gtggaacgac     1920

aatgaaatgt acttgttccg ctcttcagta gcatacgcta tgaggcagta tttccttaaa     1980

gtaaaaaatc agatgatctt gtttggcgaa gaagatgtcc gcgttgctaa ccttaagcca     2040

agaatttcgt tcaacttttt tgttaccgca ccaaagaatg tctcagacat cataccccgc     2100

actgaagtag aaaaagcgat tagaatgtcg cgtagtcgta tcaacgacgc gtttaggctc     2160

aacgacaatt cgctggaatt cctgggaatt cagcccacat tgggccctcc aaaccagcct     2220

ccggtgtcgg agaatctcta cttccagggt accggtcatc accaccacca ccatcaccat     2280

catcattga                                                             2289


<210>  16
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence;  ACE2 F504X


<220>
<221>  misc_feature
<222>  (1519)..(1521)
<223>  n is a, c, g, t or u

<400>  16
atgaaatttc tggtcaatgt agccctggta ttcatggtcg tctacatctc gtatatatat       60

gcctcgacaa tagaagaaca agctaagact tttctcgaca aatttaacca tgaagcagag      120

gacctcttct accagtcatc gttggcatcg tggaactaca acacgaatat aaccgaggaa      180

aacgttcaga atatgaacaa cgccggcgat aagtggagcg ccttccttaa ggagcaatct      240

acgctggccc agatgtatcc cttgcaggag attcaaaatc ttacggttaa gcttcagctg      300

caggccctgc agcaaaatgg ttcaagcgta ctcagtgaag ataaatctaa gagactgaat      360

acaattctca acaccatgag caccatttac tctacaggaa aggtgtgcaa ccccgataat      420

ccacaagagt gcctgttgct ggagcctggc ctcaatgaaa ttatggcaaa cagtcttgac      480

tacaatgaga ggctctgggc gtgggagtct tggaggagtg aggtgggaaa gcagctgcgc      540

ccactgtatg aagagtatgt agtccttaag aacgagatgg cgcgcgcaaa tcattatgag      600

gattatggag attactggcg tggcgactat gaagtgaatg gcgtcgacgg atacgattat      660

tcgcgcggcc aactcatcga ggatgtagag cacactttcg aagagataaa gcctttgtac      720

gagcaccttc acgcgtacgt tagggccaag cttatgaatg cttacccatc ttatattagc      780

cctatcggct gcctgcctgc gcatctgttg ggagatatgt ggggtcgctt ctggaccaac      840

ctctattctc ttactgtccc attcggccaa aagccaaata tcgacgtgac agatgccatg      900

gtcgatcaag catgggacgc ccaaaggata ttcaaggaag ccgaaaaatt ttttgttagt      960

gtcggcctcc ccaacatgac gcaaggtttc tgggagaatt ctatgctcac ggatccaggt     1020

aacgtgcaga aggccgtatg ccaccccaca gcctgggact tgggtaaagg agacttcagg     1080

attttgatgt gtaccaaagt taccatggat gattttctga ctgcacacca cgaaatgggc     1140

cacattcagt atgatatggc ttacgctgct caaccatttc ttcttcgcaa tggagccaac     1200

gagggatttc atgaagcagt aggtgaaata atgtcgctga gtgcggcaac accgaagcac     1260

cttaagtcca ttggactgct cagccccgac tttcaggaag ataacgagac ggagataaac     1320

ttcctgctca agcaggcact cacgatcgtg ggaacgttgc cttttacgta tatgcttgaa     1380

aagtggagat ggatggtgtt caaaggcgaa atacctaaag accagtggat gaaaaagtgg     1440

tgggaaatga agagagaaat agtcggagtc gtcgaacccg tgccgcatga tgaaacctac     1500

tgcgatcctg ccagcttgnn ncatgtgagt aatgattata gtttcatacg ctactatact     1560

cgcacgttgt accagtttca atttcaggag gccctgtgtc aagcggcaaa gcatgaggga     1620

ccgctgcaca agtgcgacat aagtaatagc actgaggctg gacaaaagct gtttaacatg     1680

ctgcgtctcg gaaagagtga gccttggact ctcgcactgg aaaatgtcgt tggcgcgaaa     1740

aacatgaatg tacgtccgct tctgaattac tttgagccat tgtttacatg gttgaaagat     1800

cagaataaaa atagttttgt gggctggtca acggattgga gcccttacgc tgatcaatct     1860

ataaaggtga gaatatccct taagagtgcg ttgggagata aggcatacga gtggaacgac     1920

aatgaaatgt acttgttccg ctcttcagta gcatacgcta tgaggcagta tttccttaaa     1980

gtaaaaaatc agatgatctt gtttggcgaa gaagatgtcc gcgttgctaa ccttaagcca     2040

agaatttcgt tcaacttttt tgttaccgca ccaaagaatg tctcagacat cataccccgc     2100

actgaagtag aaaaagcgat tagaatgtcg cgtagtcgta tcaacgacgc gtttaggctc     2160

aacgacaatt cgctggaatt cctgggaatt cagcccacat tgggccctcc aaaccagcct     2220

ccggtgtcgg agaatctcta cttccagggt accggtcatc accaccacca ccatcaccat     2280

catcattga                                                             2289


<210>  17
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; ACE2 H505X


<220>
<221>  misc_feature
<222>  (1522)..(1524)
<223>  n is a, c, g, t or u

<400>  17
atgaaatttc tggtcaatgt agccctggta ttcatggtcg tctacatctc gtatatatat       60

gcctcgacaa tagaagaaca agctaagact tttctcgaca aatttaacca tgaagcagag      120

gacctcttct accagtcatc gttggcatcg tggaactaca acacgaatat aaccgaggaa      180

aacgttcaga atatgaacaa cgccggcgat aagtggagcg ccttccttaa ggagcaatct      240

acgctggccc agatgtatcc cttgcaggag attcaaaatc ttacggttaa gcttcagctg      300

caggccctgc agcaaaatgg ttcaagcgta ctcagtgaag ataaatctaa gagactgaat      360

acaattctca acaccatgag caccatttac tctacaggaa aggtgtgcaa ccccgataat      420

ccacaagagt gcctgttgct ggagcctggc ctcaatgaaa ttatggcaaa cagtcttgac      480

tacaatgaga ggctctgggc gtgggagtct tggaggagtg aggtgggaaa gcagctgcgc      540

ccactgtatg aagagtatgt agtccttaag aacgagatgg cgcgcgcaaa tcattatgag      600

gattatggag attactggcg tggcgactat gaagtgaatg gcgtcgacgg atacgattat      660

tcgcgcggcc aactcatcga ggatgtagag cacactttcg aagagataaa gcctttgtac      720

gagcaccttc acgcgtacgt tagggccaag cttatgaatg cttacccatc ttatattagc      780

cctatcggct gcctgcctgc gcatctgttg ggagatatgt ggggtcgctt ctggaccaac      840

ctctattctc ttactgtccc attcggccaa aagccaaata tcgacgtgac agatgccatg      900

gtcgatcaag catgggacgc ccaaaggata ttcaaggaag ccgaaaaatt ttttgttagt      960

gtcggcctcc ccaacatgac gcaaggtttc tgggagaatt ctatgctcac ggatccaggt     1020

aacgtgcaga aggccgtatg ccaccccaca gcctgggact tgggtaaagg agacttcagg     1080

attttgatgt gtaccaaagt taccatggat gattttctga ctgcacacca cgaaatgggc     1140

cacattcagt atgatatggc ttacgctgct caaccatttc ttcttcgcaa tggagccaac     1200

gagggatttc atgaagcagt aggtgaaata atgtcgctga gtgcggcaac accgaagcac     1260

cttaagtcca ttggactgct cagccccgac tttcaggaag ataacgagac ggagataaac     1320

ttcctgctca agcaggcact cacgatcgtg ggaacgttgc cttttacgta tatgcttgaa     1380

aagtggagat ggatggtgtt caaaggcgaa atacctaaag accagtggat gaaaaagtgg     1440

tgggaaatga agagagaaat agtcggagtc gtcgaacccg tgccgcatga tgaaacctac     1500

tgcgatcctg ccagcttgtt tnnngtgagt aatgattata gtttcatacg ctactatact     1560

cgcacgttgt accagtttca atttcaggag gccctgtgtc aagcggcaaa gcatgaggga     1620

ccgctgcaca agtgcgacat aagtaatagc actgaggctg gacaaaagct gtttaacatg     1680

ctgcgtctcg gaaagagtga gccttggact ctcgcactgg aaaatgtcgt tggcgcgaaa     1740

aacatgaatg tacgtccgct tctgaattac tttgagccat tgtttacatg gttgaaagat     1800

cagaataaaa atagttttgt gggctggtca acggattgga gcccttacgc tgatcaatct     1860

ataaaggtga gaatatccct taagagtgcg ttgggagata aggcatacga gtggaacgac     1920

aatgaaatgt acttgttccg ctcttcagta gcatacgcta tgaggcagta tttccttaaa     1980

gtaaaaaatc agatgatctt gtttggcgaa gaagatgtcc gcgttgctaa ccttaagcca     2040

agaatttcgt tcaacttttt tgttaccgca ccaaagaatg tctcagacat cataccccgc     2100

actgaagtag aaaaagcgat tagaatgtcg cgtagtcgta tcaacgacgc gtttaggctc     2160

aacgacaatt cgctggaatt cctgggaatt cagcccacat tgggccctcc aaaccagcct     2220

ccggtgtcgg agaatctcta cttccagggt accggtcatc accaccacca ccatcaccat     2280

catcattga                                                             2289


<210>  18
<211>  2223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; ACE2 T371W

<400>  18
atgaaatttc tggtcaatgt agccctggta ttcatggtcg tctacatctc gtatatatat       60

gcctcgacaa tagaagaaca agctaagact tttctcgaca aatttaacca tgaagcagag      120

gacctcttct accagtcatc gttggcatcg tggaactaca acacgaatat aaccgaggaa      180

aacgttcaga atatgaacaa cgccggcgat aagtggagcg ccttccttaa ggagcaatct      240

acgctggccc agatgtatcc cttgcaggag attcaaaatc ttacggttaa gcttcagctg      300

caggccctgc agcaaaatgg ttcaagcgta ctcagtgaag ataaatctaa gagactgaat      360

acaattctca acaccatgag caccatttac tctacaggaa aggtgtgcaa ccccgataat      420

ccacaagagt gcctgttgct ggagcctggc ctcaatgaaa ttatggcaaa cagtcttgac      480

tacaatgaga ggctctgggc gtgggagtct tggaggagtg aggtgggaaa gcagctgcgc      540

ccactgtatg aagagtatgt agtccttaag aacgagatgg cgcgcgcaaa tcattatgag      600

gattatggag attactggcg tggcgactat gaagtgaatg gcgtcgacgg atacgattat      660

tcgcgcggcc aactcatcga ggatgtagag cacactttcg aagagataaa gcctttgtac      720

gagcaccttc acgcgtacgt tagggccaag cttatgaatg cttacccatc ttatattagc      780

cctatcggct gcctgcctgc gcatctgttg ggagatatgt ggggtcgctt ctggaccaac      840

ctctattctc ttactgtccc attcggccaa aagccaaata tcgacgtgac agatgccatg      900

gtcgatcaag catgggacgc ccaaaggata ttcaaggaag ccgaaaaatt ttttgttagt      960

gtcggcctcc ccaacatgac gcaaggtttc tgggagaatt ctatgctcac ggatccaggt     1020

aacgtgcaga aggccgtatg ccaccccaca gcctgggact tgggtaaagg agacttcagg     1080

attttgatgt gtaccaaagt taccatggat gattttctgt gggcacacca cgaaatgggc     1140

cacattcagt atgatatggc ttacgctgct caaccatttc ttcttcgcaa tggagccaac     1200

gagggatttc atgaagcagt aggtgaaata atgtcgctga gtgcggcaac accgaagcac     1260

cttaagtcca ttggactgct cagccccgac tttcaggaag ataacgagac ggagataaac     1320

ttcctgctca agcaggcact cacgatcgtg ggaacgttgc cttttacgta tatgcttgaa     1380

aagtggagat ggatggtgtt caaaggcgaa atacctaaag accagtggat gaaaaagtgg     1440

tgggaaatga agagagaaat agtcggagtc gtcgaacccg tgccgcatga tgaaacctac     1500

tgcgatcctg ccagcttgtt tcatgtgagt aatgattata gtttcatacg ctactatact     1560

cgcacgttgt accagtttca atttcaggag gccctgtgtc aagcggcaaa gcatgaggga     1620

ccgctgcaca agtgcgacat aagtaatagc actgaggctg gacaaaagct gtttaacatg     1680

ctgcgtctcg gaaagagtga gccttggact ctcgcactgg aaaatgtcgt tggcgcgaaa     1740

aacatgaatg tacgtccgct tctgaattac tttgagccat tgtttacatg gttgaaagat     1800

cagaataaaa atagttttgt gggctggtca acggattgga gcccttacgc tgatcaatct     1860

ataaaggtga gaatatccct taagagtgcg ttgggagata aggcatacga gtggaacgac     1920

aatgaaatgt acttgttccg ctcttcagta gcatacgcta tgaggcagta tttccttaaa     1980

gtaaaaaatc agatgatctt gtttggcgaa gaagatgtcc gcgttgctaa ccttaagcca     2040

agaatttcgt tcaacttttt tgttaccgca ccaaagaatg tctcagacat cataccccgc     2100

actgaagtag aaaaagcgat tagaatgtcg cgtagtcgta tcaacgacgc gtttaggctc     2160

aacgacaatt cgctggaatt cctgggaatt cagcccacat tgggccctcc aaaccagcct     2220

ccg                                                                   2223


<210>  19
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; Melittin signal peptide

<400>  19

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala 
            20      


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; TEV recognition site

<400>  20

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; His tag

<400>  21

His His His His His His His His His His 
1               5                   10  


<210>  22
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; ACE2 T371W/G732C

<400>  22

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu 
            20                  25                  30          


Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu 
        35                  40                  45              


Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn 
    50                  55                  60                  


Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser 
65                  70                  75                  80  


Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val 
                85                  90                  95      


Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser 
            100                 105                 110         


Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr 
        115                 120                 125             


Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys 
    130                 135                 140                 


Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp 
145                 150                 155                 160 


Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly 
                165                 170                 175     


Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu 
            180                 185                 190         


Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly 
        195                 200                 205             


Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln 
    210                 215                 220                 


Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr 
225                 230                 235                 240 


Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro 
                245                 250                 255     


Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp 
            260                 265                 270         


Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe 
        275                 280                 285             


Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala 
    290                 295                 300                 


Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser 
305                 310                 315                 320 


Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu 
                325                 330                 335     


Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp 
            340                 345                 350         


Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr 
        355                 360                 365             


Met Asp Asp Phe Leu Trp Ala His His Glu Met Gly His Ile Gln Tyr 
    370                 375                 380                 


Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn 
385                 390                 395                 400 


Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala 
                405                 410                 415     


Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln 
            420                 425                 430         


Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr 
        435                 440                 445             


Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp 
    450                 455                 460                 


Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp 
465                 470                 475                 480 


Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His 
                485                 490                 495     


Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp 
            500                 505                 510         


Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe 
        515                 520                 525             


Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys 
    530                 535                 540                 


Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met 
545                 550                 555                 560 


Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val 
                565                 570                 575     


Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu 
            580                 585                 590         


Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly 
        595                 600                 605             


Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg 
    610                 615                 620                 


Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp 
625                 630                 635                 640 


Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln 
                645                 650                 655     


Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp 
            660                 665                 670         


Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val 
        675                 680                 685             


Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu 
    690                 695                 700                 


Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu 
705                 710                 715                 720 


Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Cys Pro 
                725                 730                 735     


Pro Asn Gln Pro Pro Val Ser Glu Asn Leu Tyr Phe Gln Gly Thr Gly 
            740                 745                 750         


His His His His His His His His His His 
        755                 760         


<210>  23
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; ACE2 T371W/S740C

<400>  23

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu 
            20                  25                  30          


Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu 
        35                  40                  45              


Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn 
    50                  55                  60                  


Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser 
65                  70                  75                  80  


Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val 
                85                  90                  95      


Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser 
            100                 105                 110         


Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr 
        115                 120                 125             


Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys 
    130                 135                 140                 


Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp 
145                 150                 155                 160 


Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly 
                165                 170                 175     


Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu 
            180                 185                 190         


Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly 
        195                 200                 205             


Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln 
    210                 215                 220                 


Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr 
225                 230                 235                 240 


Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro 
                245                 250                 255     


Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp 
            260                 265                 270         


Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe 
        275                 280                 285             


Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala 
    290                 295                 300                 


Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser 
305                 310                 315                 320 


Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu 
                325                 330                 335     


Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp 
            340                 345                 350         


Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr 
        355                 360                 365             


Met Asp Asp Phe Leu Trp Ala His His Glu Met Gly His Ile Gln Tyr 
    370                 375                 380                 


Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn 
385                 390                 395                 400 


Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala 
                405                 410                 415     


Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln 
            420                 425                 430         


Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr 
        435                 440                 445             


Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp 
    450                 455                 460                 


Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp 
465                 470                 475                 480 


Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His 
                485                 490                 495     


Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp 
            500                 505                 510         


Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe 
        515                 520                 525             


Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys 
    530                 535                 540                 


Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met 
545                 550                 555                 560 


Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val 
                565                 570                 575     


Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu 
            580                 585                 590         


Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly 
        595                 600                 605             


Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg 
    610                 615                 620                 


Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp 
625                 630                 635                 640 


Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln 
                645                 650                 655     


Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp 
            660                 665                 670         


Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val 
        675                 680                 685             


Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu 
    690                 695                 700                 


Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu 
705                 710                 715                 720 


Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro 
                725                 730                 735     


Pro Asn Gln Pro Pro Val Cys Glu Asn Leu Tyr Phe Gln Gly Thr Gly 
            740                 745                 750         


His His His His His His His His His His 
        755                 760         


<210>  24
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; ACE2 T371W/G732C

<400>  24
atgaaatttc tggtcaatgt agccctggta ttcatggtcg tctacatctc gtatatatat       60

gcctcgacaa tagaagaaca agctaagact tttctcgaca aatttaacca tgaagcagag      120

gacctcttct accagtcatc gttggcatcg tggaactaca acacgaatat aaccgaggaa      180

aacgttcaga atatgaacaa cgccggcgat aagtggagcg ccttccttaa ggagcaatct      240

acgctggccc agatgtatcc cttgcaggag attcaaaatc ttacggttaa gcttcagctg      300

caggccctgc agcaaaatgg ttcaagcgta ctcagtgaag ataaatctaa gagactgaat      360

acaattctca acaccatgag caccatttac tctacaggaa aggtgtgcaa ccccgataat      420

ccacaagagt gcctgttgct ggagcctggc ctcaatgaaa ttatggcaaa cagtcttgac      480

tacaatgaga ggctctgggc gtgggagtct tggaggagtg aggtgggaaa gcagctgcgc      540

ccactgtatg aagagtatgt agtccttaag aacgagatgg cgcgcgcaaa tcattatgag      600

gattatggag attactggcg tggcgactat gaagtgaatg gcgtcgacgg atacgattat      660

tcgcgcggcc aactcatcga ggatgtagag cacactttcg aagagataaa gcctttgtac      720

gagcaccttc acgcgtacgt tagggccaag cttatgaatg cttacccatc ttatattagc      780

cctatcggct gcctgcctgc gcatctgttg ggagatatgt ggggtcgctt ctggaccaac      840

ctctattctc ttactgtccc attcggccaa aagccaaata tcgacgtgac agatgccatg      900

gtcgatcaag catgggacgc ccaaaggata ttcaaggaag ccgaaaaatt ttttgttagt      960

gtcggcctcc ccaacatgac gcaaggtttc tgggagaatt ctatgctcac ggatccaggt     1020

aacgtgcaga aggccgtatg ccaccccaca gcctgggact tgggtaaagg agacttcagg     1080

attttgatgt gtaccaaagt taccatggat gattttctgt gggcacacca cgaaatgggc     1140

cacattcagt atgatatggc ttacgctgct caaccatttc ttcttcgcaa tggagccaac     1200

gagggatttc atgaagcagt aggtgaaata atgtcgctga gtgcggcaac accgaagcac     1260

cttaagtcca ttggactgct cagccccgac tttcaggaag ataacgagac ggagataaac     1320

ttcctgctca agcaggcact cacgatcgtg ggaacgttgc cttttacgta tatgcttgaa     1380

aagtggagat ggatggtgtt caaaggcgaa atacctaaag accagtggat gaaaaagtgg     1440

tgggaaatga agagagaaat agtcggagtc gtcgaacccg tgccgcatga tgaaacctac     1500

tgcgatcctg ccagcttgtt tcatgtgagt aatgattata gtttcatacg ctactatact     1560

cgcacgttgt accagtttca atttcaggag gccctgtgtc aagcggcaaa gcatgaggga     1620

ccgctgcaca agtgcgacat aagtaatagc actgaggctg gacaaaagct gtttaacatg     1680

ctgcgtctcg gaaagagtga gccttggact ctcgcactgg aaaatgtcgt tggcgcgaaa     1740

aacatgaatg tacgtccgct tctgaattac tttgagccat tgtttacatg gttgaaagat     1800

cagaataaaa atagttttgt gggctggtca acggattgga gcccttacgc tgatcaatct     1860

ataaaggtga gaatatccct taagagtgcg ttgggagata aggcatacga gtggaacgac     1920

aatgaaatgt acttgttccg ctcttcagta gcatacgcta tgaggcagta tttccttaaa     1980

gtaaaaaatc agatgatctt gtttggcgaa gaagatgtcc gcgttgctaa ccttaagcca     2040

agaatttcgt tcaacttttt tgttaccgca ccaaagaatg tctcagacat cataccccgc     2100

actgaagtag aaaaagcgat tagaatgtcg cgtagtcgta tcaacgacgc gtttaggctc     2160

aacgacaatt cgctggaatt cctgggaatt cagcccacat tgtgccctcc aaaccagcct     2220

ccggtgtcgg agaatctcta cttccagggt accggtcatc accaccacca ccatcaccat     2280

catcattga                                                             2289


<210>  25
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; ACE2 T371W/S740C

<400>  25
atgaaatttc tggtcaatgt agccctggta ttcatggtcg tctacatctc gtatatatat       60

gcctcgacaa tagaagaaca agctaagact tttctcgaca aatttaacca tgaagcagag      120

gacctcttct accagtcatc gttggcatcg tggaactaca acacgaatat aaccgaggaa      180

aacgttcaga atatgaacaa cgccggcgat aagtggagcg ccttccttaa ggagcaatct      240

acgctggccc agatgtatcc cttgcaggag attcaaaatc ttacggttaa gcttcagctg      300

caggccctgc agcaaaatgg ttcaagcgta ctcagtgaag ataaatctaa gagactgaat      360

acaattctca acaccatgag caccatttac tctacaggaa aggtgtgcaa ccccgataat      420

ccacaagagt gcctgttgct ggagcctggc ctcaatgaaa ttatggcaaa cagtcttgac      480

tacaatgaga ggctctgggc gtgggagtct tggaggagtg aggtgggaaa gcagctgcgc      540

ccactgtatg aagagtatgt agtccttaag aacgagatgg cgcgcgcaaa tcattatgag      600

gattatggag attactggcg tggcgactat gaagtgaatg gcgtcgacgg atacgattat      660

tcgcgcggcc aactcatcga ggatgtagag cacactttcg aagagataaa gcctttgtac      720

gagcaccttc acgcgtacgt tagggccaag cttatgaatg cttacccatc ttatattagc      780

cctatcggct gcctgcctgc gcatctgttg ggagatatgt ggggtcgctt ctggaccaac      840

ctctattctc ttactgtccc attcggccaa aagccaaata tcgacgtgac agatgccatg      900

gtcgatcaag catgggacgc ccaaaggata ttcaaggaag ccgaaaaatt ttttgttagt      960

gtcggcctcc ccaacatgac gcaaggtttc tgggagaatt ctatgctcac ggatccaggt     1020

aacgtgcaga aggccgtatg ccaccccaca gcctgggact tgggtaaagg agacttcagg     1080

attttgatgt gtaccaaagt taccatggat gattttctgt gggcacacca cgaaatgggc     1140

cacattcagt atgatatggc ttacgctgct caaccatttc ttcttcgcaa tggagccaac     1200

gagggatttc atgaagcagt aggtgaaata atgtcgctga gtgcggcaac accgaagcac     1260

cttaagtcca ttggactgct cagccccgac tttcaggaag ataacgagac ggagataaac     1320

ttcctgctca agcaggcact cacgatcgtg ggaacgttgc cttttacgta tatgcttgaa     1380

aagtggagat ggatggtgtt caaaggcgaa atacctaaag accagtggat gaaaaagtgg     1440

tgggaaatga agagagaaat agtcggagtc gtcgaacccg tgccgcatga tgaaacctac     1500

tgcgatcctg ccagcttgtt tcatgtgagt aatgattata gtttcatacg ctactatact     1560

cgcacgttgt accagtttca atttcaggag gccctgtgtc aagcggcaaa gcatgaggga     1620

ccgctgcaca agtgcgacat aagtaatagc actgaggctg gacaaaagct gtttaacatg     1680

ctgcgtctcg gaaagagtga gccttggact ctcgcactgg aaaatgtcgt tggcgcgaaa     1740

aacatgaatg tacgtccgct tctgaattac tttgagccat tgtttacatg gttgaaagat     1800

cagaataaaa atagttttgt gggctggtca acggattgga gcccttacgc tgatcaatct     1860

ataaaggtga gaatatccct taagagtgcg ttgggagata aggcatacga gtggaacgac     1920

aatgaaatgt acttgttccg ctcttcagta gcatacgcta tgaggcagta tttccttaaa     1980

gtaaaaaatc agatgatctt gtttggcgaa gaagatgtcc gcgttgctaa ccttaagcca     2040

agaatttcgt tcaacttttt tgttaccgca ccaaagaatg tctcagacat cataccccgc     2100

actgaagtag aaaaagcgat tagaatgtcg cgtagtcgta tcaacgacgc gtttaggctc     2160

aacgacaatt cgctggaatt cctgggaatt cagcccacat tgggccctcc aaaccagcct     2220

ccggtgtgcg agaatctcta cttccagggt accggtcatc accaccacca ccatcaccat     2280

catcattga                                                             2289


