                         SEQUENCE LISTING

<110>  Ibex Biosciences, Inc.
 
<120>  ANTIBODIES TARGETED TO CD147

<130>  IBEX-005/01WO 325614-2042

<150>  US 63/135,827
<151>  2021-01-11

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Phe Val Gln Ala Pro Leu Ser Gln 
            20                  25                  30          


Gln Arg Trp Val Gly Gly Ser Val Glu Leu His Cys Glu Ala Val Gly 
        35                  40                  45              


Ser Pro Val Pro Glu Ile Gln Trp Trp Phe Glu Gly Gln Gly Pro Asn 
    50                  55                  60                  


Asp Thr Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 
65                  70                  75                  80  


Ile His Ala Thr Tyr His Gln His Ala Ala Ser Thr Ile Ser Ile Asp 
                85                  90                  95      


Thr Leu Val Glu Glu Asp Thr Gly Thr Tyr Glu Cys Arg Ala Ser Asn 
            100                 105                 110         


Asp Pro Asp Arg Asn His Leu Thr Arg Ala Pro Arg Val Lys Trp Val 
        115                 120                 125             


Arg Ala Gln Ala Val Val Leu Val Leu Glu Pro Gly Thr Val Phe Thr 
    130                 135                 140                 


Thr Val Glu Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn 
145                 150                 155                 160 


Asp Ser Ala Thr Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val 
                165                 170                 175     


Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val 
            180                 185                 190         


Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu 
        195                 200                 205             


Pro Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys 
    210                 215                 220                 


Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu 
225                 230                 235                 240 


Val Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr 
                245                 250                 255     


Lys Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser 
            260                 265                 270         


Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu 
        275                 280                 285             


Asn Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr 
    290                 295                 300                 


Ser Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser 
305                 310                 315                 320 


His Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu 
                325                 330                 335     


Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu 
            340                 345                 350         


Asp Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser 
        355                 360                 365             


Gly Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser 
    370                 375                 380                 


Ser 
385 


<210>  2
<211>  389
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Ala Ala Leu Leu Leu Ala Leu Ala Phe Thr Leu Leu Ser Gly 
1               5                   10                  15      


Gln Gly Ala Cys Ala Ala Ala Gly Phe Leu Lys Ala Pro Leu Ser Gln 
            20                  25                  30          


Glu Arg Trp Ala Gly Gly Ser Val Val Leu His Cys Glu Ala Val Gly 
        35                  40                  45              


Ser Pro Ile Pro Glu Ile Gln Trp Trp Phe Glu Gly Asn Ala Pro Asn 
    50                  55                  60                  


Asp Ser Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 
65                  70                  75                  80  


Ile His Ala Ala Tyr Arg Gln His Ala Ala Ser Ser Leu Ser Val Asp 
                85                  90                  95      


Gly Leu Thr Ala Glu Asp Thr Gly Thr Tyr Glu Cys Arg Ala Ser Ser 
            100                 105                 110         


Asp Pro Asp Arg Asn His Leu Thr Arg Pro Pro Arg Val Lys Trp Val 
        115                 120                 125             


Arg Ala Gln Ala Ser Val Val Val Leu Glu Pro Gly Thr Ile Gln Thr 
    130                 135                 140                 


Ser Val Gln Glu Val Asn Ser Lys Thr Gln Leu Thr Cys Ser Leu Asn 
145                 150                 155                 160 


Ser Ser Gly Val Asp Ile Val Gly His Arg Trp Met Arg Gly Gly Lys 
                165                 170                 175     


Val Leu Gln Glu Asp Thr Leu Pro Asp Leu His Thr Lys Tyr Ile Val 
            180                 185                 190         


Asp Ala Asp Asp Arg Ser Gly Glu Tyr Ser Cys Ile Phe Leu Pro Glu 
        195                 200                 205             


Pro Val Gly Arg Ser Glu Ile Asn Val Glu Gly Pro Pro Arg Ile Lys 
    210                 215                 220                 


Val Gly Lys Lys Ser Glu His Ser Ser Glu Gly Glu Leu Ala Lys Leu 
225                 230                 235                 240 


Val Cys Lys Ser Asp Ala Ser Tyr Pro Pro Ile Thr Asp Trp Phe Trp 
                245                 250                 255     


Phe Lys Thr Ser Asp Thr Gly Glu Glu Glu Ala Ile Thr Asn Ser Thr 
            260                 265                 270         


Glu Ala Asn Gly Lys Tyr Val Val Val Ser Thr Pro Glu Lys Ser Gln 
        275                 280                 285             


Leu Thr Ile Ser Asn Leu Asp Val Asn Val Asp Pro Gly Thr Tyr Val 
    290                 295                 300                 


Cys Asn Ala Thr Asn Ala Gln Gly Thr Thr Arg Glu Thr Ile Ser Leu 
305                 310                 315                 320 


Arg Val Arg Ser Arg Met Ala Ala Leu Trp Pro Phe Leu Gly Ile Val 
                325                 330                 335     


Ala Glu Val Leu Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg 
            340                 345                 350         


Arg Lys Pro Asp Gln Thr Leu Asp Glu Asp Asp Pro Gly Ala Ala Pro 
        355                 360                 365             


Leu Lys Gly Ser Gly Thr His Met Asn Asp Lys Asp Lys Asn Val Arg 
    370                 375                 380                 


Gln Arg Asn Ala Thr 
385                 


<210>  3
<211>  388
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Ala Ala Ala Leu Leu Leu Ala Leu Ala Phe Thr Phe Leu Ser Gly 
1               5                   10                  15      


Gln Gly Ala Cys Ala Ala Ala Gly Phe Leu Lys Ala Pro Met Ser Gln 
            20                  25                  30          


Glu Gln Trp Ala Gly Gly Ser Val Val Leu His Cys Glu Ala Val Gly 
        35                  40                  45              


Ser Pro Met Pro Glu Ile Gln Trp Trp Phe Glu Gly Asn Glu Pro Asn 
    50                  55                  60                  


Asp Ser Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 
65                  70                  75                  80  


Ile His Ala Thr Tyr Arg Gln His Ala Ala Ser Thr Leu Ser Val Asp 
                85                  90                  95      


Gly Leu Ala Ala Glu Asp Thr Gly Thr Tyr Glu Cys Arg Ala Ser Ser 
            100                 105                 110         


Asp Pro Asp Arg Asn His Leu Thr Arg Pro Pro Arg Val Lys Trp Val 
        115                 120                 125             


Arg Ala Gln Ala Ser Val Val Val Leu Glu Pro Gly Thr Ile Val Thr 
    130                 135                 140                 


Ser Val Gln Glu Val Asp Ser Lys Thr Gln Leu Thr Cys Phe Leu Asn 
145                 150                 155                 160 


Ser Ser Gly Ile Asp Ile Val Gly His Arg Trp Met Arg Gly Gly Lys 
                165                 170                 175     


Val Leu Gln Glu Asp Thr Leu Pro Asp Leu Gln Met Lys Tyr Thr Val 
            180                 185                 190         


Asp Ala Asp Asp Arg Ser Gly Glu Tyr Ser Cys Ile Phe Leu Pro Glu 
        195                 200                 205             


Pro Val Gly Arg Gly Asn Ile Asn Val Glu Gly Pro Pro Arg Ile Lys 
    210                 215                 220                 


Val Gly Lys Lys Ser Glu His Ala Ser Glu Gly Glu Phe Val Lys Leu 
225                 230                 235                 240 


Ile Cys Lys Ser Glu Ala Ser His Pro Pro Val Asp Glu Trp Val Trp 
                245                 250                 255     


Phe Lys Thr Ser Asp Thr Gly Asp Gln Thr Ile Ser Asn Gly Thr Glu 
            260                 265                 270         


Ala Asn Ser Lys Tyr Val Ile Ile Ser Thr Pro Glu Leu Ser Glu Leu 
        275                 280                 285             


Ile Ile Ser Asp Leu Asp Met Asn Val Asp Pro Gly Thr Tyr Val Cys 
    290                 295                 300                 


Asn Ala Thr Asn Ser Gln Gly Ser Ala Arg Glu Thr Ile Ser Leu Arg 
305                 310                 315                 320 


Val Arg Ser Arg Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala 
                325                 330                 335     


Glu Val Leu Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg 
            340                 345                 350         


Lys Pro Asp Gln Thr Leu Asp Glu Asp Asp Pro Gly Ala Ala Pro Leu 
        355                 360                 365             


Lys Gly Ser Gly Ser His Leu Asn Asp Lys Asp Lys Asn Val Arg Gln 
    370                 375                 380                 


Arg Asn Ala Thr 
385             


<210>  4
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VHH Antibody-Fragment Crystallizable (Fc) Fusion Construct Ibx-11-Fc

<400>  4

Gln Val Arg Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ala Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Val Val Asp Asn Thr Gly Ser Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Gly Pro Lys Asn Tyr Leu Gly Ser His Glu Tyr Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro 
    130                 135                 140                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
145                 150                 155                 160 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                165                 170                 175     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            180                 185                 190         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        195                 200                 205             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    210                 215                 220                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
225                 230                 235                 240 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                245                 250                 255     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            260                 265                 270         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        275                 280                 285             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    290                 295                 300                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
305                 310                 315                 320 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                325                 330                 335     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            340                 345                 350         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360                 


<210>  5
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VHH Antibody-Fragment Crystallizable (Fc) Fusion Construct Ibx-12-Fc

<400>  5

Gln Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Gly Gly Thr Phe Thr Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Thr Thr Trp Ser Thr Gly Thr Ser Tyr Tyr Ala Tyr Ala Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Asp Asn Thr 
65                  70                  75                  80  


Val Thr Leu Thr Met Lys Arg Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Ala Asp Pro Asp Gly Ser Asp Trp Ala His Ser Ala Arg 
            100                 105                 110         


Gln Leu Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
    130                 135                 140                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
145                 150                 155                 160 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                165                 170                 175     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            180                 185                 190         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        195                 200                 205             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    210                 215                 220                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
225                 230                 235                 240 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                245                 250                 255     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            260                 265                 270         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        275                 280                 285             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    290                 295                 300                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
305                 310                 315                 320 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                325                 330                 335     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            340                 345                 350         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360                 365             


Lys 
    


<210>  6
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VHH Antibody-Fragment Crystallizable (Fc) Fusion Construct Ibx-13-Fc

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Asp Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Thr Ala Asn Gly Ile Ala Thr Arg Tyr Asn Asp Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Gly Ala Asp Thr Arg Arg Phe Ser Leu Pro Ser Thr Val His Glu Ile 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His 
    130                 135                 140                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
145                 150                 155                 160 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                165                 170                 175     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            180                 185                 190         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        195                 200                 205             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    210                 215                 220                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
225                 230                 235                 240 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                245                 250                 255     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            260                 265                 270         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        275                 280                 285             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    290                 295                 300                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
305                 310                 315                 320 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                325                 330                 335     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            340                 345                 350         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360                 365         


<210>  7
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VHH Antibody-Fragment Crystallizable (Fc) Fusion Construct Ibx-14-Fc

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Ser Leu Ser Ser Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Thr Thr Trp His Ala Gly Thr Gln Tyr Tyr Ala Tyr Ala Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Asn Thr 
65                  70                  75                  80  


Val Ser Leu Gln Met Lys Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ala Val Ser Gly Pro Gly Tyr Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
    130                 135                 140                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
145                 150                 155                 160 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                165                 170                 175     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            180                 185                 190         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        195                 200                 205             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    210                 215                 220                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
225                 230                 235                 240 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                245                 250                 255     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            260                 265                 270         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        275                 280                 285             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    290                 295                 300                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                325                 330                 335     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360         


<210>  8
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VHH Antibody-Fragment Crystallizable (Fc) Fusion Construct Ibx-74 (dimer of IBX-11)

<400>  8

Gln Val Arg Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ala Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Val Val Asp Asn Thr Gly Ser Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Gly Pro Lys Asn Tyr Leu Gly Ser His Glu Tyr Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ile Pro Gln 
        115                 120                 125             


Pro Gln Pro Lys Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Lys 
    130                 135                 140                 


Pro Gln Pro Glu Pro Gln Val Arg Leu Glu Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu 
                165                 170                 175     


Ala Phe Ser Ile Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Glu Arg Glu Phe Val Ser Val Val Asp Asn Thr Gly Ser Thr Thr Leu 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    210                 215                 220                 


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gly Ala Gly Pro Lys Asn Tyr Leu Gly Ser His 
                245                 250                 255     


Glu Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270     


<210>  9
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VHH Antibody-Fragment Crystallizable (Fc) Fusion Construct Ibx-75 (dimer of IBX-12)

<400>  9

Gln Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Gly Gly Thr Phe Thr Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Thr Thr Trp Ser Thr Gly Thr Ser Tyr Tyr Ala Tyr Ala Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Asp Asn Thr 
65                  70                  75                  80  


Val Thr Leu Thr Met Lys Arg Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Ala Asp Pro Asp Gly Ser Asp Trp Ala His Ser Ala Arg 
            100                 105                 110         


Gln Leu Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu 
        115                 120                 125             


Pro Lys Ile Pro Gln Pro Gln Pro Lys Pro Gln Pro Gln Pro Gln Pro 
    130                 135                 140                 


Gln Pro Gln Pro Lys Pro Gln Pro Glu Pro Gln Val Arg Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Gln Ala Ser Gly Gly Thr Phe Thr Thr Tyr Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Gln Glu Arg Glu Phe Val Ser Ala Thr Thr Trp Ser 
        195                 200                 205             


Thr Gly Thr Ser Tyr Tyr Ala Tyr Ala Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Thr Ser Arg Asp Asn Asp Asn Thr Val Thr Leu Thr Met Lys 
225                 230                 235                 240 


Arg Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ser Ala Asp Pro 
                245                 250                 255     


Asp Gly Ser Asp Trp Ala His Ser Ala Arg Gln Leu Arg Tyr Trp Gly 
            260                 265                 270         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        275                 280     


<210>  10
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VHH Antibody-Fragment Crystallizable (Fc) Fusion Construct Ibx-76 (dimer of IBX-13)

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Asp Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Thr Ala Asn Gly Ile Ala Thr Arg Tyr Asn Asp Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Gly Ala Asp Thr Arg Arg Phe Ser Leu Pro Ser Thr Val His Glu Ile 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys 
        115                 120                 125             


Ile Pro Gln Pro Gln Pro Lys Pro Gln Pro Gln Pro Gln Pro Gln Pro 
    130                 135                 140                 


Gln Pro Lys Pro Gln Pro Glu Pro Gln Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala 
                165                 170                 175     


Ser Glu Asp Thr Phe Ser Thr Tyr Ala Ile Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Gln Gly Arg Glu Phe Val Ala Gly Ile Thr Ala Asn Gly Ile 
        195                 200                 205             


Ala Thr Arg Tyr Asn Asp Ser Leu Lys Asp Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Ser Cys Gly Ala Asp Thr Arg Arg Phe Ser 
                245                 250                 255     


Leu Pro Ser Thr Val His Glu Ile Asp Tyr Trp Gly Gln Gly Thr Gln 
            260                 265                 270         


Val Thr Val Ser Ser 
        275         


<210>  11
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VHH Antibody-Fragment Crystallizable (Fc) Fusion Construct Ibx-77 (dimer of IBX-14)

<400>  11

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Ser Leu Ser Ser Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Thr Thr Trp His Ala Gly Thr Gln Tyr Tyr Ala Tyr Ala Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Asn Thr 
65                  70                  75                  80  


Val Ser Leu Gln Met Lys Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ala Val Ser Gly Pro Gly Tyr Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ile Pro Gln Pro Gln 
        115                 120                 125             


Pro Lys Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Lys Pro Gln 
    130                 135                 140                 


Pro Glu Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Ala Gly Asp Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Ser Leu 
                165                 170                 175     


Ser Ser Asn Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            180                 185                 190         


Glu Phe Val Ser Gly Thr Thr Trp His Ala Gly Thr Gln Tyr Tyr Ala 
        195                 200                 205             


Tyr Ala Ala Asp Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn 
    210                 215                 220                 


Ala Asn Thr Val Ser Leu Gln Met Lys Arg Leu Lys Pro Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Ala Ala Val Ser Gly Pro Gly Tyr Asp Ser 
                245                 250                 255     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265         


<210>  12
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody Construct Ibx-11

<400>  12

Gln Val Arg Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ala Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Val Val Asp Asn Thr Gly Ser Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Gly Pro Lys Asn Tyr Leu Gly Ser His Glu Tyr Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  13
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody Construct Ibx-12

<400>  13

Gln Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Gly Gly Thr Phe Thr Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Thr Thr Trp Ser Thr Gly Thr Ser Tyr Tyr Ala Tyr Ala Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Asp Asn Thr 
65                  70                  75                  80  


Val Thr Leu Thr Met Lys Arg Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Ala Asp Pro Asp Gly Ser Asp Trp Ala His Ser Ala Arg 
            100                 105                 110         


Gln Leu Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  14
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody Construct Ibx-13

<400>  14

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Asp Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Thr Ala Asn Gly Ile Ala Thr Arg Tyr Asn Asp Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Gly Ala Asp Thr Arg Arg Phe Ser Leu Pro Ser Thr Val His Glu Ile 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  15
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody Construct Ibx-14

<400>  15

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Ser Leu Ser Ser Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Thr Thr Trp His Ala Gly Thr Gln Tyr Tyr Ala Tyr Ala Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Asn Thr 
65                  70                  75                  80  


Val Ser Leu Gln Met Lys Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ala Val Ser Gly Pro Gly Tyr Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-11 CDR1

<400>  16

Gly Leu Ala Phe Ser Ile Tyr Gly Met Gly 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-12 CDR1

<400>  17

Gly Gly Thr Phe Thr Thr Tyr Ala Met Gly 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-13 CDR1

<400>  18

Glu Asp Thr Phe Ser Thr Tyr Ala Ile Gly 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-14 CDR1

<400>  19

Gly Arg Ser Leu Ser Ser Asn Ala Met Gly 
1               5                   10  


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-11 (flanking framework) CDR1

<400>  20

Ala Ser Gly Leu Ala Phe Ser Ile Tyr Gly Met Gly Trp Phe 
1               5                   10                  


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-12 (flanking framework) CDR1

<400>  21

Ala Ser Gly Gly Thr Phe Thr Thr Tyr Ala Met Gly Trp Phe 
1               5                   10                  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-13 (flanking framework) CDR1

<400>  22

Ala Ser Glu Asp Thr Phe Ser Thr Tyr Ala Ile Gly Trp Phe 
1               5                   10                  


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-14 (flanking framework) CDR1

<400>  23

Ala Ser Gly Arg Ser Leu Ser Ser Asn Ala Met Gly Trp Phe 
1               5                   10                  


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-11 CDR2

<400>  24

Val Val Asp Asn Thr Gly Ser Thr Thr Leu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-12 CDR2

<400>  25

Ala Thr Thr Trp Ser Thr Gly Thr Ser Tyr Tyr Ala Tyr Ala Ala Asp 
1               5                   10                  15      


Ser Val Lys Gly 
            20  


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-13 CDR2

<400>  26

Gly Ile Thr Ala Asn Gly Ile Ala Thr Arg Tyr Asn Asp Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  27
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-14 CDR2

<400>  27

Gly Thr Thr Trp His Ala Gly Thr Gln Tyr Tyr Ala Tyr Ala Ala Asp 
1               5                   10                  15      


Ser Val Lys Gly 
            20  


<210>  28
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-11 (flanking framework) CDR2

<400>  28

Val Ser Val Val Asp Asn Thr Gly Ser Thr Thr Leu Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  29
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-12 (flanking framework) CDR2

<400>  29

Val Ser Ala Thr Thr Trp Ser Thr Gly Thr Ser Tyr Tyr Ala Tyr Ala 
1               5                   10                  15      


Ala Asp Ser Val Lys Gly Arg Phe 
            20                  


<210>  30
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-13 (flanking framework) CDR2

<400>  30

Val Ala Gly Ile Thr Ala Asn Gly Ile Ala Thr Arg Tyr Asn Asp Ser 
1               5                   10                  15      


Leu Lys Asp Arg Phe 
            20      


<210>  31
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-14 (flanking framework) CDR2

<400>  31

Val Ser Gly Thr Thr Trp His Ala Gly Thr Gln Tyr Tyr Ala Tyr Ala 
1               5                   10                  15      


Ala Asp Ser Val Lys Gly Arg Phe 
            20                  


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-11 CDR3

<400>  32

Gly Ala Gly Pro Lys Asn Tyr Leu Gly Ser His Glu Tyr Ala Tyr 
1               5                   10                  15  


<210>  33
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-12 CDR3

<400>  33

Ser Ala Asp Pro Asp Gly Ser Asp Trp Ala His Ser Ala Arg Gln Leu 
1               5                   10                  15      


Arg Tyr 
        


<210>  34
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-13 CDR3

<400>  34

Gly Ala Asp Thr Arg Arg Phe Ser Leu Pro Ser Thr Val His Glu Ile 
1               5                   10                  15      


Asp Tyr 
        


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-14 CDR3

<400>  35

Ala Ala Ala Val Ser Gly Pro Gly Tyr Asp Ser 
1               5                   10      


<210>  36
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-11 (flanking framework) CDR3

<400>  36

Tyr Cys Gly Ala Gly Pro Lys Asn Tyr Leu Gly Ser His Glu Tyr Ala 
1               5                   10                  15      


Tyr Trp Gly 
            


<210>  37
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-12 (flanking framework) CDR3

<400>  37

Tyr Cys Ser Ala Asp Pro Asp Gly Ser Asp Trp Ala His Ser Ala Arg 
1               5                   10                  15      


Gln Leu Arg Tyr Trp Gly 
            20          


<210>  38
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-13 (flanking framework) CDR3

<400>  38

Ser Cys Gly Ala Asp Thr Arg Arg Phe Ser Leu Pro Ser Thr Val His 
1               5                   10                  15      


Glu Ile Asp Tyr Trp Gly 
            20          


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibx-14 (flanking framework) CDR3

<400>  39

Tyr Cys Ala Ala Ala Val Ser Gly Pro Gly Tyr Asp Ser Trp Gly 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker

<400>  40

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  41
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker

<400>  41

Glu Pro Lys Ile Pro Gln Pro Gln Pro Lys Pro Gln Pro Gln Pro Gln 
1               5                   10                  15      


Pro Gln Pro Gln Pro Lys Pro Gln Pro Glu Pro 
            20                  25          


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  flag tag

<400>  42

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


