                         SEQUENCE LISTING

<110>  Vedere Bio II, Inc.
        
<120>  OPTOGENETIC COMPOSITIONS COMPRISING A CBh PROMOTER SEQUENCE AND 
       METHODS FOR USE

<130>  VEDE-009/01WO 342178-2045

<150>  US 63/136,140
<151>  2021-01-11

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  812
<212>  DNA
<213>  Artificial

<220>
<223>  Made in Lab - CBH promoter sequence

<400>  1
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtcgag gtgagcccca cgttctgctt cactctcccc atctcccccc cctccccacc      360

cccaattttg tatttattta ttttttaatt attttgtgca gcgatggggg cggggggggg      420

gggggggcgc gcgccaggcg gggcggggcg gggcgagggg cggggcgggg cgaggcggag      480

aggtgcggcg gcagccaatc agagcggcgc gctccgaaag tttcctttta tggcgaggcg      540

gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg gcgggagtcg ctgcgacgct      600

gccttcgccc cgtgccccgc tccgccgccg cctcgcgccg cccgccccgg ctctgactga      660

ccgcgttact cccacaggtg agcgggcggg acggcccttc tcctccgggc tgtaattagc      720

tgagcaagag gtaagggttt aagggatggt tggttggtgg ggtattaatg tttaattacc      780

tggagcacct gcctgaaatc actttttttc ag                                    812


<210>  2
<211>  6846
<212>  DNA
<213>  Homo sapiens

<400>  2
aagctgttcc tgcagccgat atcaggatgt gccgaaatga aacggacaag gcaactgtta       60

acattataga ccccagagtt ttaacacagg tcctctgatg acaaggttgt gatttttctc      120

tgtcttttgt cagcagcatc tagctcaccg ctgccaacac gacttccact gtactcttga      180

tcaatttacc ttgatgcact accggtgaag aacggggact cgaattccct tacaaacgcc      240

tccagcttgt agaggcggtc gtggaggacc cagaggagga gacgaagggg aaggaggcgg      300

tggtggagga ggcaaaggcc ttggacgacc attgttggcg aggggcacca ctccgggaga      360

ggcggcgctg ggcgtcttgg gggtgcgcgc cgggagcctg cagcgggacc agcgtgggaa      420

cgcggctggc aggctgtgga cctcgtcctc accaccatgg tcgggctcct tttgtttttt      480

ttcccagcga tctttttgga ggtgtccctt ctccccagaa gccccggcag gaaagtgttg      540

ctggcaggag cgtcgtctca gcgctcggtg gccagaatgg acggagatgt catcattgga      600

gccctcttct cagtccatca ccagcctccg gccgagaaag tgcccgagag gaagtgtggg      660

gagatcaggg agcagtatgg catccagagg gtggaggcca tgttccacac gttggataag      720

atcaacgcgg acccggtcct cctgcccaac atcaccctgg gcagtgagat ccgggactcc      780

tgctggcact cttccgtggc tctggaacag agcattgagt tcattaggga ctctctgatt      840

tccattcgag atgagaagga tgggatcaac cggtgtctgc ctgacggcca gtccctcccc      900

ccaggcagga ctaagaagcc cattgcggga gtgatcggtc ccggctccag ctctgtagcc      960

attcaagtgc agaacctgct ccagctcttc gacatccccc agatcgctta ttcagccaca     1020

agcatcgacc tgagtgacaa aactttgtac aaatacttcc tgagggttgt cccttctgac     1080

actttgcagg caagggccat gcttgacata gtcaaacgtt acaattggac ctatgtctct     1140

gcagtccaca cggaagggaa ttatggggag agcggaatgg acgctttcaa agagctggct     1200

gcccaggaag gcctctgtat cgcccattct gacaaaatct acagcaacgc tggggagaag     1260

agctttgacc gactcttgcg caaactccga gagaggcttc ccaaggctag agtggtggtc     1320

tgcttctgtg aaggcatgac agtgcgagga ctcctgagcg ccatgcggcg ccttggcgtc     1380

gtgggcgagt tctcactcat tggaagtgat ggatgggcag acagagatga agtcattgaa     1440

ggttatgagg tggaagccaa cgggggaatc acgataaagc tgcagtctcc agaggtcagg     1500

tcatttgatg attatttcct gaaactgagg ctggacacta acacgaggaa tccctggttc     1560

cctgagttct ggcaacatcg gttccagtgc cgccttccag gacaccttct ggaaaatccc     1620

aactttaaac gaatctgcac aggcaatgaa agcttagaag aaaactatgt ccaggacagt     1680

aagatggggt ttgtcatcaa tgccatctat gccatggcac atgggctgca gaacatgcac     1740

catgccctct gccctggcca cgtgggcctc tgcgatgcca tgaagcccat cgacggcagc     1800

aagctgctgg acttcctcat caagtcctca ttcattggag tatctggaga ggaggtgtgg     1860

tttgatgaga aaggagacgc tcctggaagg tatgatatca tgaatctgca gtacactgaa     1920

gctaatcgct atgactatgt gcacgttgga acctggcatg aaggagtgct gaacattgat     1980

gattacaaaa tccagatgaa caagagtgga gtggtgcggt ctgtgtgcag tgagccttgc     2040

ttaaagggcc agattaaggt tatacggaaa ggagaagtga gctgctgctg gatttgcacg     2100

gcctgcaaag agaatgaata tgtgcaagat gagttcacct gcaaagcttg tgacttggga     2160

tggtggccca atgcagatct aacaggctgt gagcccattc ctgtgcgcta tcttgagtgg     2220

agcaacatcg aatccattat agccatcgcc ttttcatgcc tgggaatcct tgttaccttg     2280

tttgtcaccc taatctttgt actgtaccgg gacacaccag tggtcaaatc ctccagtcgg     2340

gagctctgct acatcatcct agctggcatc ttccttggtt atgtgtgccc attcactctc     2400

attgccaaac ctactaccac ctcctgctac ctccagcgcc tcttggttgg cctctcctct     2460

gcgatgtgct actctgcttt agtgactaaa accaatcgta ttgcacgcat cctggctggc     2520

agcaagaaga agatctgcac ccggaagccc aggttcatga gtgcctgggc tcaggtgatc     2580

attgcctcaa ttctgattag tgtgcaacta accctggtgg taaccctgat catcatggaa     2640

ccccctatgc ccattctgtc ctacccaagt atcaaggaag tctaccttat ctgcaatacc     2700

agcaacctgg gtgtggtggc ccctttgggc tacaatggac tcctcatcat gagctgtacc     2760

tactatgcct tcaagacccg caacgtgccc gccaacttca acgaggccaa atatatcgcg     2820

ttcaccatgt acaccacctg tatcatctgg ctagcttttg tgcccattta ctttgggagc     2880

aactacaaga tcatcacaac ttgctttgca gtgagtctca gtgtaacagt ggctctgggg     2940

tgcatgttca ctcccaagat gtacatcatt attgccaagc ctgagaggaa tgtccgcagt     3000

gccttcacca cctctgatgt tgtccgcatg catgttggcg atggcaagct gccctgccgc     3060

tccaacactt tcctcaacat cttccgaaga aagaaggcag gggcagggaa tgccaattct     3120

aatggcaagt ctgtgtcatg gtctgaacca ggtggaggac aggtgcccaa gggacagcat     3180

atgtggcacc gcctctctgt gcacgtgaag accaatgaga cggcctgcaa ccaaacagcc     3240

gtcatcaagc ccctcactaa aagttaccaa ggctctggca agagcctgac cttttcagat     3300

accagcacca agacccttta caacgtagag gaggaggagg atgcccagcc gattcgcttt     3360

agcccgcctg gtagcccttc catggtggtg cacaggcgcg tgccaagcgc ggcgaccact     3420

ccgcctctgc cgtcccacct gaccgcagag gagacccccc tcttcctggc cgaaccagcc     3480

ctccccaagg gcttgccccc tcctctccag cagcagcagc aaccccctcc acagcagaaa     3540

tcgctgatgg accagctcca gggagtggtc agcaacttca gtaccgcgat cccggatttt     3600

cacgcggtgc tggcaggccc cggtggtccc gggaacgggc tgcggtccct gtacccgccc     3660

ccgccacctc cgcagcacct gcagatgctg ccgctgcagc tgagcacctt tggggaggag     3720

ctggtctccc cgcccgcgga cgacgacgac gacagcgaga ggtttaagct cctccaggag     3780

tacgtgtatg agcacgagcg ggaagggaac acggaagaag acgaactgga agaggaggag     3840

gaggacctgc aggcggccag caaactgacc ccggatgatt cgcctgcgct gacgcctccg     3900

tcgcctttcc gcgactcggt ggcctcgggc agctcggtgc ccagctcccc cgtgtccgag     3960

tcggtgctct gcacccctcc caacgtatcc tacgcctctg tcattctgcg ggactacaag     4020

caaagctctt ccaccctgta agggggaagg gtccacatag aaaagcaaga caagccagag     4080

atctcccaca cctccagaga tgtgcaaaca gctgggagga aaagcctggg agtggggggc     4140

ctcgtcggga ggacaggaga ccgctgctgc tgctgccgct actgctgctg ctgccttaag     4200

taggaagaga gggaaggaca ccaagcaaaa aatgttccag gccaggattc ggattcttga     4260

attactcgaa gccttctctg ggaagaaagg gaattctgac aaagcacaat tccatatggt     4320

atgtaacttt tatcacaaat caaatagtga catcacaaac ataatgtcct cttttgcaca     4380

attgtgcata gatatatata tgcccacaca cactgggcca tgcttgccaa ggaacagccc     4440

acgtggacat gccagtcgga tcatgagttc acctgatggc attcggagtg agctggtgga     4500

gccagacaga gcaggtgcgg ggaagggaag ggcccaggcc agacccatcc caaacggatg     4560

atgggatgat gggacagcag ctccttgctc agaagccctt ctccccgctg ggctgacaga     4620

ctcctcatct tcaggagact caggaatgga gcggcacagg ggtctctctt catccactgc     4680

aacccatcca gtgccagctt tgagattgca cttgaagaaa ggtgcatgga ccccctgctg     4740

ctctgcagat tccctttatt taggaaaaca ggaataagag caaaattatc accaaaaagt     4800

gcttcatcag gcgtgctaca ggaggaagga gctagaaata gaacaatcca tcagcatgag     4860

actttgaaaa aaaaacacat gatcagcttc tcatgttcca tattcactta ttggcgattt     4920

ggggaaaagg ccggaacaag agattgttac gagagtggca gaaacccttt tgtagattga     4980

cttgtgtttg tgccaagcgg gctttccatt gaccttcagt taaagaacaa accatgtgac     5040

aaaattgtta ccttccactt actgtagcaa ataataccta caagttgaac ttctaagatg     5100

cgtatatgta caatttggtg ccattatttc tcctacgtat tagagaaaca aatccatctt     5160

tgaatctaat ggtgtactca tagcaactat tactggttta aatgacaaat aattctatcc     5220

tattgtcact gaagtccttg taactagcga gtgaatgtgt tcctgtgtcc ttgtatatgt     5280

gcgatcgtaa aatttgtgca atgtaatgtc aaattgactg gtcaatgtca acctagtagt     5340

caatctaact gcaattagaa attgtctttt gaatatacta tatatatttt ttatgttcca     5400

ataatgtttt gtacatcatt gtcatcaata tctacagaag ctctttgacg gtttgaatac     5460

tatggctcaa ggttttcata tgcagctcgg atggacattt ttcttctaag atggaactta     5520

tttttcagat attttctgat gtggagatat gttattaatg aagtggtttg aaaatttgtt     5580

atattaaaag tgcacaaaaa ctgagagtga aaataaaagg tacattttat aagcttgcac     5640

acattattaa cacataagat tgaacaaagc atttagatta ttccaggtta tatcattttt     5700

ttaaagattt tccacagcta cttgagtgtc taacatacag taacatctaa ctcagctaat     5760

aatttgtaaa atctttatca atcacatttt gccttctttt aatttttatg ttcatggact     5820

tttattcctg tgtcttggct gtcataactt tttatttctg ctatttgctg ttgtgtaata     5880

tccatggaca tgtaatccac ttactccatc tttacaatcc ctttttacca ccaataaaag     5940

gatttttctt gctgttttga tttcttctat tatttgtgga atgaattata ccccccttaa     6000

atatctttgt ttatgcctta tgttcagtca tattttaata tgcttccttc atattgaagc     6060

tgctgatttc tcagccaaaa atcatcttag aatctttaaa tatccattgc atcatttgtt     6120

cagaatttaa catccattcc aatgttggag gcttgtatta cttatatttc atcatattct     6180

attgccaagt ttagtcagtt ccacaccaag aatgaactgc atttccttta aaaattattt     6240

taaaacacct ttattgaaaa gatctcatga ctgagatgtg gactttggtt ccatgttttc     6300

attgtaagaa agcagagagc ggaaaatcaa tggctccagt gattaataga tgggttttta     6360

gtaattgaca aattcatgag ggaaagcata tgatctcttt attagtgaat catgcttatt     6420

ttttactctt aatgccacta atatacatcc ctaatatcac agggcttgtg cattcagatt     6480

tttaaaaaat taggatagat aaggaaacaa cttatattca agtgtaagat gatatcaggt     6540

tggtctaaga cttttggtga acacgttcat tcaactgtga tcactttatt actctgaatg     6600

cctactatta tcctgattat ggggtctcct gaataaatag agtattagtc cttatgtcat     6660

cattgttcaa aattggagat gtacacatac ataccctata ccaagagggc cgaaactctt     6720

caccttgatg tatgttctga tacaagttgt tcagcttctt gtaaatgtgt tttccttcgg     6780

cttgttactg ccttttgtca aataatcttg acaatgctgt ataataaata ttttctattt     6840

attaaa                                                                6846


<210>  3
<211>  1194
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Gly Leu Leu Leu Phe Phe Phe Pro Ala Ile Phe Leu Glu Val 
1               5                   10                  15      


Ser Leu Leu Pro Arg Ser Pro Gly Arg Lys Val Leu Leu Ala Gly Ala 
            20                  25                  30          


Ser Ser Gln Arg Ser Val Ala Arg Met Asp Gly Asp Val Ile Ile Gly 
        35                  40                  45              


Ala Leu Phe Ser Val His His Gln Pro Pro Ala Glu Lys Val Pro Glu 
    50                  55                  60                  


Arg Lys Cys Gly Glu Ile Arg Glu Gln Tyr Gly Ile Gln Arg Val Glu 
65                  70                  75                  80  


Ala Met Phe His Thr Leu Asp Lys Ile Asn Ala Asp Pro Val Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ser Glu Ile Arg Asp Ser Cys Trp His Ser 
            100                 105                 110         


Ser Val Ala Leu Glu Gln Ser Ile Glu Phe Ile Arg Asp Ser Leu Ile 
        115                 120                 125             


Ser Ile Arg Asp Glu Lys Asp Gly Ile Asn Arg Cys Leu Pro Asp Gly 
    130                 135                 140                 


Gln Ser Leu Pro Pro Gly Arg Thr Lys Lys Pro Ile Ala Gly Val Ile 
145                 150                 155                 160 


Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn Leu Leu Gln 
                165                 170                 175     


Leu Phe Asp Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser Ile Asp Leu 
            180                 185                 190         


Ser Asp Lys Thr Leu Tyr Lys Tyr Phe Leu Arg Val Val Pro Ser Asp 
        195                 200                 205             


Thr Leu Gln Ala Arg Ala Met Leu Asp Ile Val Lys Arg Tyr Asn Trp 
    210                 215                 220                 


Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly Glu Ser Gly 
225                 230                 235                 240 


Met Asp Ala Phe Lys Glu Leu Ala Ala Gln Glu Gly Leu Cys Ile Ala 
                245                 250                 255     


His Ser Asp Lys Ile Tyr Ser Asn Ala Gly Glu Lys Ser Phe Asp Arg 
            260                 265                 270         


Leu Leu Arg Lys Leu Arg Glu Arg Leu Pro Lys Ala Arg Val Val Val 
        275                 280                 285             


Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Ser Ala Met Arg 
    290                 295                 300                 


Arg Leu Gly Val Val Gly Glu Phe Ser Leu Ile Gly Ser Asp Gly Trp 
305                 310                 315                 320 


Ala Asp Arg Asp Glu Val Ile Glu Gly Tyr Glu Val Glu Ala Asn Gly 
                325                 330                 335     


Gly Ile Thr Ile Lys Leu Gln Ser Pro Glu Val Arg Ser Phe Asp Asp 
            340                 345                 350         


Tyr Phe Leu Lys Leu Arg Leu Asp Thr Asn Thr Arg Asn Pro Trp Phe 
        355                 360                 365             


Pro Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Pro Gly His Leu 
    370                 375                 380                 


Leu Glu Asn Pro Asn Phe Lys Arg Ile Cys Thr Gly Asn Glu Ser Leu 
385                 390                 395                 400 


Glu Glu Asn Tyr Val Gln Asp Ser Lys Met Gly Phe Val Ile Asn Ala 
                405                 410                 415     


Ile Tyr Ala Met Ala His Gly Leu Gln Asn Met His His Ala Leu Cys 
            420                 425                 430         


Pro Gly His Val Gly Leu Cys Asp Ala Met Lys Pro Ile Asp Gly Ser 
        435                 440                 445             


Lys Leu Leu Asp Phe Leu Ile Lys Ser Ser Phe Ile Gly Val Ser Gly 
    450                 455                 460                 


Glu Glu Val Trp Phe Asp Glu Lys Gly Asp Ala Pro Gly Arg Tyr Asp 
465                 470                 475                 480 


Ile Met Asn Leu Gln Tyr Thr Glu Ala Asn Arg Tyr Asp Tyr Val His 
                485                 490                 495     


Val Gly Thr Trp His Glu Gly Val Leu Asn Ile Asp Asp Tyr Lys Ile 
            500                 505                 510         


Gln Met Asn Lys Ser Gly Val Val Arg Ser Val Cys Ser Glu Pro Cys 
        515                 520                 525             


Leu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val Ser Cys Cys 
    530                 535                 540                 


Trp Ile Cys Thr Ala Cys Lys Glu Asn Glu Tyr Val Gln Asp Glu Phe 
545                 550                 555                 560 


Thr Cys Lys Ala Cys Asp Leu Gly Trp Trp Pro Asn Ala Asp Leu Thr 
                565                 570                 575     


Gly Cys Glu Pro Ile Pro Val Arg Tyr Leu Glu Trp Ser Asn Ile Glu 
            580                 585                 590         


Ser Ile Ile Ala Ile Ala Phe Ser Cys Leu Gly Ile Leu Val Thr Leu 
        595                 600                 605             


Phe Val Thr Leu Ile Phe Val Leu Tyr Arg Asp Thr Pro Val Val Lys 
    610                 615                 620                 


Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly Ile Phe Leu 
625                 630                 635                 640 


Gly Tyr Val Cys Pro Phe Thr Leu Ile Ala Lys Pro Thr Thr Thr Ser 
                645                 650                 655     


Cys Tyr Leu Gln Arg Leu Leu Val Gly Leu Ser Ser Ala Met Cys Tyr 
            660                 665                 670         


Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile Leu Ala Gly 
        675                 680                 685             


Ser Lys Lys Lys Ile Cys Thr Arg Lys Pro Arg Phe Met Ser Ala Trp 
    690                 695                 700                 


Ala Gln Val Ile Ile Ala Ser Ile Leu Ile Ser Val Gln Leu Thr Leu 
705                 710                 715                 720 


Val Val Thr Leu Ile Ile Met Glu Pro Pro Met Pro Ile Leu Ser Tyr 
                725                 730                 735     


Pro Ser Ile Lys Glu Val Tyr Leu Ile Cys Asn Thr Ser Asn Leu Gly 
            740                 745                 750         


Val Val Ala Pro Leu Gly Tyr Asn Gly Leu Leu Ile Met Ser Cys Thr 
        755                 760                 765             


Tyr Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe Asn Glu Ala 
    770                 775                 780                 


Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
785                 790                 795                 800 


Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile Thr Thr Cys 
                805                 810                 815     


Phe Ala Val Ser Leu Ser Val Thr Val Ala Leu Gly Cys Met Phe Thr 
            820                 825                 830         


Pro Lys Met Tyr Ile Ile Ile Ala Lys Pro Glu Arg Asn Val Arg Ser 
        835                 840                 845             


Ala Phe Thr Thr Ser Asp Val Val Arg Met His Val Gly Asp Gly Lys 
    850                 855                 860                 


Leu Pro Cys Arg Ser Asn Thr Phe Leu Asn Ile Phe Arg Arg Lys Lys 
865                 870                 875                 880 


Ala Gly Ala Gly Asn Ala Asn Ser Asn Gly Lys Ser Val Ser Trp Ser 
                885                 890                 895     


Glu Pro Gly Gly Gly Gln Val Pro Lys Gly Gln His Met Trp His Arg 
            900                 905                 910         


Leu Ser Val His Val Lys Thr Asn Glu Thr Ala Cys Asn Gln Thr Ala 
        915                 920                 925             


Val Ile Lys Pro Leu Thr Lys Ser Tyr Gln Gly Ser Gly Lys Ser Leu 
    930                 935                 940                 


Thr Phe Ser Asp Thr Ser Thr Lys Thr Leu Tyr Asn Val Glu Glu Glu 
945                 950                 955                 960 


Glu Asp Ala Gln Pro Ile Arg Phe Ser Pro Pro Gly Ser Pro Ser Met 
                965                 970                 975     


Val Val His Arg Arg Val Pro Ser Ala Ala Thr Thr Pro Pro Leu Pro 
            980                 985                 990         


Ser His Leu Thr Ala Glu Glu Thr  Pro Leu Phe Leu Ala  Glu Pro Ala 
        995                 1000                 1005             


Leu Pro  Lys Gly Leu Pro Pro  Pro Leu Gln Gln Gln  Gln Gln Pro 
    1010                 1015                 1020             


Pro Pro  Gln Gln Lys Ser Leu  Met Asp Gln Leu Gln  Gly Val Val 
    1025                 1030                 1035             


Ser Asn  Phe Ser Thr Ala Ile  Pro Asp Phe His Ala  Val Leu Ala 
    1040                 1045                 1050             


Gly Pro  Gly Gly Pro Gly Asn  Gly Leu Arg Ser Leu  Tyr Pro Pro 
    1055                 1060                 1065             


Pro Pro  Pro Pro Gln His Leu  Gln Met Leu Pro Leu  Gln Leu Ser 
    1070                 1075                 1080             


Thr Phe  Gly Glu Glu Leu Val  Ser Pro Pro Ala Asp  Asp Asp Asp 
    1085                 1090                 1095             


Asp Ser  Glu Arg Phe Lys Leu  Leu Gln Glu Tyr Val  Tyr Glu His 
    1100                 1105                 1110             


Glu Arg  Glu Gly Asn Thr Glu  Glu Asp Glu Leu Glu  Glu Glu Glu 
    1115                 1120                 1125             


Glu Asp  Leu Gln Ala Ala Ser  Lys Leu Thr Pro Asp  Asp Ser Pro 
    1130                 1135                 1140             


Ala Leu  Thr Pro Pro Ser Pro  Phe Arg Asp Ser Val  Ala Ser Gly 
    1145                 1150                 1155             


Ser Ser  Val Pro Ser Ser Pro  Val Ser Glu Ser Val  Leu Cys Thr 
    1160                 1165                 1170             


Pro Pro  Asn Val Ser Tyr Ala  Ser Val Ile Leu Arg  Asp Tyr Lys 
    1175                 1180                 1185             


Gln Ser  Ser Ser Thr Leu 
    1190                 


<210>  4
<211>  6917
<212>  DNA
<213>  Homo sapiens

<400>  4
agagctgagg cgtctgcaag ccgagcgtgg ccacggtcct ctggccccgg gaccatagcg       60

ctgtctaccc cgactcaggt actcaggtat gtctcaagtc catgtcctcc aaacagactc      120

agcatctagc tcaccgctgc caacacgact tccactgtac tcttgatcaa tttaccttga      180

tgcactaccg gtgaagaacg gggactcgaa ttcccttaca aacgcctcca gcttgtagag      240

gcggtcgtgg aggacccaga ggaggagacg aaggggaagg aggcggtggt ggaggaggca      300

aaggccttgg acgaccattg ttggcgaggg gcaccactcc gggagaggcg gcgctgggcg      360

tcttgggggt gcgcgccggg agcctgcagc gggaccagcg tgggaacgcg gctggcaggc      420

tgtggacctc gtcctcacca ccatggtcgg gctccttttg ttttttttcc cagcgatctt      480

tttggaggtg tcccttctcc ccagaagccc cggcaggaaa gtgttgctgg caggagcgtc      540

gtctcagcgc tcggtggcca gaatggacgg agatgtcatc attggagccc tcttctcagt      600

ccatcaccag cctccggccg agaaagtgcc cgagaggaag tgtggggaga tcagggagca      660

gtatggcatc cagagggtgg aggccatgtt ccacacgttg gataagatca acgcggaccc      720

ggtcctcctg cccaacatca ccctgggcag tgagatccgg gactcctgct ggcactcttc      780

cgtggctctg gaacagagca ttgagttcat tagggactct ctgatttcca ttcgagatga      840

gaaggatggg atcaaccggt gtctgcctga cggccagtcc ctccccccag gcaggactaa      900

gaagcccatt gcgggagtga tcggtcccgg ctccagctct gtagccattc aagtgcagaa      960

cctgctccag ctcttcgaca tcccccagat cgcttattca gccacaagca tcgacctgag     1020

tgacaaaact ttgtacaaat acttcctgag ggttgtccct tctgacactt tgcaggcaag     1080

ggccatgctt gacatagtca aacgttacaa ttggacctat gtctctgcag tccacacgga     1140

agggaattat ggggagagcg gaatggacgc tttcaaagag ctggctgccc aggaaggcct     1200

ctgtatcgcc cattctgaca aaatctacag caacgctggg gagaagagct ttgaccgact     1260

cttgcgcaaa ctccgagaga ggcttcccaa ggctagagtg gtggtctgct tctgtgaagg     1320

catgacagtg cgaggactcc tgagcgccat gcggcgcctt ggcgtcgtgg gcgagttctc     1380

actcattgga agtgatggat gggcagacag agatgaagtc attgaaggtt atgaggtgga     1440

agccaacggg ggaatcacga taaagctgca gtctccagag gtcaggtcat ttgatgatta     1500

tttcctgaaa ctgaggctgg acactaacac gaggaatccc tggttccctg agttctggca     1560

acatcggttc cagtgccgcc ttccaggaca ccttctggaa aatcccaact ttaaacgaat     1620

ctgcacaggc aatgaaagct tagaagaaaa ctatgtccag gacagtaaga tggggtttgt     1680

catcaatgcc atctatgcca tggcacatgg gctgcagaac atgcaccatg ccctctgccc     1740

tggccacgtg ggcctctgcg atgccatgaa gcccatcgac ggcagcaagc tgctggactt     1800

cctcatcaag tcctcattca ttggagtatc tggagaggag gtgtggtttg atgagaaagg     1860

agacgctcct ggaaggtatg atatcatgaa tctgcagtac actgaagcta atcgctatga     1920

ctatgtgcac gttggaacct ggcatgaagg agtgctgaac attgatgatt acaaaatcca     1980

gatgaacaag agtggagtgg tgcggtctgt gtgcagtgag ccttgcttaa agggccagat     2040

taaggttata cggaaaggag aagtgagctg ctgctggatt tgcacggcct gcaaagagaa     2100

tgaatatgtg caagatgagt tcacctgcaa agcttgtgac ttgggatggt ggcccaatgc     2160

agatctaaca ggctgtgagc ccattcctgt gcgctatctt gagtggagca acatcgaatc     2220

cattatagcc atcgcctttt catgcctggg aatccttgtt accttgtttg tcaccctaat     2280

ctttgtactg taccgggaca caccagtggt caaatcctcc agtcgggagc tctgctacat     2340

catcctagct ggcatcttcc ttggttatgt gtgcccattc actctcattg ccaaacctac     2400

taccacctcc tgctacctcc agcgcctctt ggttggcctc tcctctgcga tgtgctactc     2460

tgctttagtg actaaaacca atcgtattgc acgcatcctg gctggcagca agaagaagat     2520

ctgcacccgg aagcccaggt tcatgagtgc ctgggctcag gtgatcattg cctcaattct     2580

gattagtgtg caactaaccc tggtggtaac cctgatcatc atggaacccc ctatgcccat     2640

tctgtcctac ccaagtatca aggaagtcta ccttatctgc aataccagca acctgggtgt     2700

ggtggcccct ttgggctaca atggactcct catcatgagc tgtacctact atgccttcaa     2760

gacccgcaac gtgcccgcca acttcaacga ggccaaatat atcgcgttca ccatgtacac     2820

cacctgtatc atctggctag cttttgtgcc catttacttt gggagcaact acaagatcat     2880

cacaacttgc tttgcagtga gtctcagtgt aacagtggct ctggggtgca tgttcactcc     2940

caagatgtac atcattattg ccaagcctga gaggaatgtc cgcagtgcct tcaccacctc     3000

tgatgttgtc cgcatgcatg ttggcgatgg caagctgccc tgccgctcca acactttcct     3060

caacatcttc cgaagaaaga aggcaggggc agggaatgcc aagaagaggc agccagaatt     3120

ctcgcccacc agccaatgtc cgtcggcaca tgtgcagctt tgaaaacccc cacactgcag     3180

tgaatgtttc taatggcaag tctgtgtcat ggtctgaacc aggtggagga caggtgccca     3240

agggacagca tatgtggcac cgcctctctg tgcacgtgaa gaccaatgag acggcctgca     3300

accaaacagc cgtcatcaag cccctcacta aaagttacca aggctctggc aagagcctga     3360

ccttttcaga taccagcacc aagacccttt acaacgtaga ggaggaggag gatgcccagc     3420

cgattcgctt tagcccgcct ggtagccctt ccatggtggt gcacaggcgc gtgccaagcg     3480

cggcgaccac tccgcctctg ccgtcccacc tgaccgcaga ggagaccccc ctcttcctgg     3540

ccgaaccagc cctccccaag ggcttgcccc ctcctctcca gcagcagcag caaccccctc     3600

cacagcagaa atcgctgatg gaccagctcc agggagtggt cagcaacttc agtaccgcga     3660

tcccggattt tcacgcggtg ctggcaggcc ccggtggtcc cgggaacggg ctgcggtccc     3720

tgtacccgcc cccgccacct ccgcagcacc tgcagatgct gccgctgcag ctgagcacct     3780

ttggggagga gctggtctcc ccgcccgcgg acgacgacga cgacagcgag aggtttaagc     3840

tcctccagga gtacgtgtat gagcacgagc gggaagggaa cacggaagaa gacgaactgg     3900

aagaggagga ggaggacctg caggcggcca gcaaactgac cccggatgat tcgcctgcgc     3960

tgacgcctcc gtcgcctttc cgcgactcgg tggcctcggg cagctcggtg cccagctccc     4020

ccgtgtccga gtcggtgctc tgcacccctc ccaacgtatc ctacgcctct gtcattctgc     4080

gggactacaa gcaaagctct tccaccctgt aagggggaag ggtccacata gaaaagcaag     4140

acaagccaga gatctcccac acctccagag atgtgcaaac agctgggagg aaaagcctgg     4200

gagtgggggg cctcgtcggg aggacaggag accgctgctg ctgctgccgc tactgctgct     4260

gctgccttaa gtaggaagag agggaaggac accaagcaaa aaatgttcca ggccaggatt     4320

cggattcttg aattactcga agccttctct gggaagaaag ggaattctga caaagcacaa     4380

ttccatatgg tatgtaactt ttatcacaaa tcaaatagtg acatcacaaa cataatgtcc     4440

tcttttgcac aattgtgcat agatatatat atgcccacac acactgggcc atgcttgcca     4500

aggaacagcc cacgtggaca tgccagtcgg atcatgagtt cacctgatgg cattcggagt     4560

gagctggtgg agccagacag agcaggtgcg gggaagggaa gggcccaggc cagacccatc     4620

ccaaacggat gatgggatga tgggacagca gctccttgct cagaagccct tctccccgct     4680

gggctgacag actcctcatc ttcaggagac tcaggaatgg agcggcacag gggtctctct     4740

tcatccactg caacccatcc agtgccagct ttgagattgc acttgaagaa aggtgcatgg     4800

accccctgct gctctgcaga ttccctttat ttaggaaaac aggaataaga gcaaaattat     4860

caccaaaaag tgcttcatca ggcgtgctac aggaggaagg agctagaaat agaacaatcc     4920

atcagcatga gactttgaaa aaaaaacaca tgatcagctt ctcatgttcc atattcactt     4980

attggcgatt tggggaaaag gccggaacaa gagattgtta cgagagtggc agaaaccctt     5040

ttgtagattg acttgtgttt gtgccaagcg ggctttccat tgaccttcag ttaaagaaca     5100

aaccatgtga caaaattgtt accttccact tactgtagca aataatacct acaagttgaa     5160

cttctaagat gcgtatatgt acaatttggt gccattattt ctcctacgta ttagagaaac     5220

aaatccatct ttgaatctaa tggtgtactc atagcaacta ttactggttt aaatgacaaa     5280

taattctatc ctattgtcac tgaagtcctt gtaactagcg agtgaatgtg ttcctgtgtc     5340

cttgtatatg tgcgatcgta aaatttgtgc aatgtaatgt caaattgact ggtcaatgtc     5400

aacctagtag tcaatctaac tgcaattaga aattgtcttt tgaatatact atatatattt     5460

tttatgttcc aataatgttt tgtacatcat tgtcatcaat atctacagaa gctctttgac     5520

ggtttgaata ctatggctca aggttttcat atgcagctcg gatggacatt tttcttctaa     5580

gatggaactt atttttcaga tattttctga tgtggagata tgttattaat gaagtggttt     5640

gaaaatttgt tatattaaaa gtgcacaaaa actgagagtg aaaataaaag gtacatttta     5700

taagcttgca cacattatta acacataaga ttgaacaaag catttagatt attccaggtt     5760

atatcatttt tttaaagatt ttccacagct acttgagtgt ctaacataca gtaacatcta     5820

actcagctaa taatttgtaa aatctttatc aatcacattt tgccttcttt taatttttat     5880

gttcatggac ttttattcct gtgtcttggc tgtcataact ttttatttct gctatttgct     5940

gttgtgtaat atccatggac atgtaatcca cttactccat ctttacaatc cctttttacc     6000

accaataaaa ggatttttct tgctgttttg atttcttcta ttatttgtgg aatgaattat     6060

acccccctta aatatctttg tttatgcctt atgttcagtc atattttaat atgcttcctt     6120

catattgaag ctgctgattt ctcagccaaa aatcatctta gaatctttaa atatccattg     6180

catcatttgt tcagaattta acatccattc caatgttgga ggcttgtatt acttatattt     6240

catcatattc tattgccaag tttagtcagt tccacaccaa gaatgaactg catttccttt     6300

aaaaattatt ttaaaacacc tttattgaaa agatctcatg actgagatgt ggactttggt     6360

tccatgtttt cattgtaaga aagcagagag cggaaaatca atggctccag tgattaatag     6420

atgggttttt agtaattgac aaattcatga gggaaagcat atgatctctt tattagtgaa     6480

tcatgcttat tttttactct taatgccact aatatacatc cctaatatca cagggcttgt     6540

gcattcagat ttttaaaaaa ttaggataga taaggaaaca acttatattc aagtgtaaga     6600

tgatatcagg ttggtctaag acttttggtg aacacgttca ttcaactgtg atcactttat     6660

tactctgaat gcctactatt atcctgatta tggggtctcc tgaataaata gagtattagt     6720

ccttatgtca tcattgttca aaattggaga tgtacacata cataccctat accaagaggg     6780

ccgaaactct tcaccttgat gtatgttctg atacaagttg ttcagcttct tgtaaatgtg     6840

ttttccttcg gcttgttact gccttttgtc aaataatctt gacaatgctg tataataaat     6900

attttctatt tattaaa                                                    6917


<210>  5
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Gly Leu Leu Leu Phe Phe Phe Pro Ala Ile Phe Leu Glu Val 
1               5                   10                  15      


Ser Leu Leu Pro Arg Ser Pro Gly Arg Lys Val Leu Leu Ala Gly Ala 
            20                  25                  30          


Ser Ser Gln Arg Ser Val Ala Arg Met Asp Gly Asp Val Ile Ile Gly 
        35                  40                  45              


Ala Leu Phe Ser Val His His Gln Pro Pro Ala Glu Lys Val Pro Glu 
    50                  55                  60                  


Arg Lys Cys Gly Glu Ile Arg Glu Gln Tyr Gly Ile Gln Arg Val Glu 
65                  70                  75                  80  


Ala Met Phe His Thr Leu Asp Lys Ile Asn Ala Asp Pro Val Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ser Glu Ile Arg Asp Ser Cys Trp His Ser 
            100                 105                 110         


Ser Val Ala Leu Glu Gln Ser Ile Glu Phe Ile Arg Asp Ser Leu Ile 
        115                 120                 125             


Ser Ile Arg Asp Glu Lys Asp Gly Ile Asn Arg Cys Leu Pro Asp Gly 
    130                 135                 140                 


Gln Ser Leu Pro Pro Gly Arg Thr Lys Lys Pro Ile Ala Gly Val Ile 
145                 150                 155                 160 


Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn Leu Leu Gln 
                165                 170                 175     


Leu Phe Asp Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser Ile Asp Leu 
            180                 185                 190         


Ser Asp Lys Thr Leu Tyr Lys Tyr Phe Leu Arg Val Val Pro Ser Asp 
        195                 200                 205             


Thr Leu Gln Ala Arg Ala Met Leu Asp Ile Val Lys Arg Tyr Asn Trp 
    210                 215                 220                 


Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly Glu Ser Gly 
225                 230                 235                 240 


Met Asp Ala Phe Lys Glu Leu Ala Ala Gln Glu Gly Leu Cys Ile Ala 
                245                 250                 255     


His Ser Asp Lys Ile Tyr Ser Asn Ala Gly Glu Lys Ser Phe Asp Arg 
            260                 265                 270         


Leu Leu Arg Lys Leu Arg Glu Arg Leu Pro Lys Ala Arg Val Val Val 
        275                 280                 285             


Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Ser Ala Met Arg 
    290                 295                 300                 


Arg Leu Gly Val Val Gly Glu Phe Ser Leu Ile Gly Ser Asp Gly Trp 
305                 310                 315                 320 


Ala Asp Arg Asp Glu Val Ile Glu Gly Tyr Glu Val Glu Ala Asn Gly 
                325                 330                 335     


Gly Ile Thr Ile Lys Leu Gln Ser Pro Glu Val Arg Ser Phe Asp Asp 
            340                 345                 350         


Tyr Phe Leu Lys Leu Arg Leu Asp Thr Asn Thr Arg Asn Pro Trp Phe 
        355                 360                 365             


Pro Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Pro Gly His Leu 
    370                 375                 380                 


Leu Glu Asn Pro Asn Phe Lys Arg Ile Cys Thr Gly Asn Glu Ser Leu 
385                 390                 395                 400 


Glu Glu Asn Tyr Val Gln Asp Ser Lys Met Gly Phe Val Ile Asn Ala 
                405                 410                 415     


Ile Tyr Ala Met Ala His Gly Leu Gln Asn Met His His Ala Leu Cys 
            420                 425                 430         


Pro Gly His Val Gly Leu Cys Asp Ala Met Lys Pro Ile Asp Gly Ser 
        435                 440                 445             


Lys Leu Leu Asp Phe Leu Ile Lys Ser Ser Phe Ile Gly Val Ser Gly 
    450                 455                 460                 


Glu Glu Val Trp Phe Asp Glu Lys Gly Asp Ala Pro Gly Arg Tyr Asp 
465                 470                 475                 480 


Ile Met Asn Leu Gln Tyr Thr Glu Ala Asn Arg Tyr Asp Tyr Val His 
                485                 490                 495     


Val Gly Thr Trp His Glu Gly Val Leu Asn Ile Asp Asp Tyr Lys Ile 
            500                 505                 510         


Gln Met Asn Lys Ser Gly Val Val Arg Ser Val Cys Ser Glu Pro Cys 
        515                 520                 525             


Leu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val Ser Cys Cys 
    530                 535                 540                 


Trp Ile Cys Thr Ala Cys Lys Glu Asn Glu Tyr Val Gln Asp Glu Phe 
545                 550                 555                 560 


Thr Cys Lys Ala Cys Asp Leu Gly Trp Trp Pro Asn Ala Asp Leu Thr 
                565                 570                 575     


Gly Cys Glu Pro Ile Pro Val Arg Tyr Leu Glu Trp Ser Asn Ile Glu 
            580                 585                 590         


Ser Ile Ile Ala Ile Ala Phe Ser Cys Leu Gly Ile Leu Val Thr Leu 
        595                 600                 605             


Phe Val Thr Leu Ile Phe Val Leu Tyr Arg Asp Thr Pro Val Val Lys 
    610                 615                 620                 


Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly Ile Phe Leu 
625                 630                 635                 640 


Gly Tyr Val Cys Pro Phe Thr Leu Ile Ala Lys Pro Thr Thr Thr Ser 
                645                 650                 655     


Cys Tyr Leu Gln Arg Leu Leu Val Gly Leu Ser Ser Ala Met Cys Tyr 
            660                 665                 670         


Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile Leu Ala Gly 
        675                 680                 685             


Ser Lys Lys Lys Ile Cys Thr Arg Lys Pro Arg Phe Met Ser Ala Trp 
    690                 695                 700                 


Ala Gln Val Ile Ile Ala Ser Ile Leu Ile Ser Val Gln Leu Thr Leu 
705                 710                 715                 720 


Val Val Thr Leu Ile Ile Met Glu Pro Pro Met Pro Ile Leu Ser Tyr 
                725                 730                 735     


Pro Ser Ile Lys Glu Val Tyr Leu Ile Cys Asn Thr Ser Asn Leu Gly 
            740                 745                 750         


Val Val Ala Pro Leu Gly Tyr Asn Gly Leu Leu Ile Met Ser Cys Thr 
        755                 760                 765             


Tyr Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe Asn Glu Ala 
    770                 775                 780                 


Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
785                 790                 795                 800 


Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile Thr Thr Cys 
                805                 810                 815     


Phe Ala Val Ser Leu Ser Val Thr Val Ala Leu Gly Cys Met Phe Thr 
            820                 825                 830         


Pro Lys Met Tyr Ile Ile Ile Ala Lys Pro Glu Arg Asn Val Arg Ser 
        835                 840                 845             


Ala Phe Thr Thr Ser Asp Val Val Arg Met His Val Gly Asp Gly Lys 
    850                 855                 860                 


Leu Pro Cys Arg Ser Asn Thr Phe Leu Asn Ile Phe Arg Arg Lys Lys 
865                 870                 875                 880 


Ala Gly Ala Gly Asn Ala Lys Lys Arg Gln Pro Glu Phe Ser Pro Thr 
                885                 890                 895     


Ser Gln Cys Pro Ser Ala His Val Gln Leu 
            900                 905     


<210>  6
<211>  6672
<212>  DNA
<213>  Homo sapiens

<400>  6
catctagctc accgctgcca acacgacttc cactgtactc ttgatcaatt taccttgatg       60

cactaccggt gaagaacggg gactcgaatt cccttacaaa cgcctccagc ttgtagaggc      120

ggtcgtggag gacccagagg aggagacgaa ggggaaggag gcggtggtgg aggaggcaaa      180

ggccttggac gaccattgtt ggcgaggggc accactccgg gagaggcggc gctgggcgtc      240

ttgggggtgc gcgccgggag cctgcagcgg gaccagcgtg ggaacgcggc tggcaggctg      300

tggacctcgt cctcaccacc atggtcgggc tccttttgtt ttttttccca gcgatctttt      360

tggaggtgtc ccttctcccc agaagccccg gcaggaaagt gttgctggca ggagcgtcgt      420

ctcagcgctc ggtggccaga atggacggag atgtcatcat tggagccctc ttctcagtcc      480

atcaccagcc tccggccgag aaagtgcccg agaggaagtg tggggagatc agggagcagt      540

atggcatcca gagggtggag gccatgttcc acacgttgga taagatcaac gcggacccgg      600

tcctcctgcc caacatcacc ctgggcagtg agatccggga ctcctgctgg cactcttccg      660

tggctctgga acagagcatt gagttcatta gggactctct gatttccatt cgagatgaga      720

aggatgggat caaccggtgt ctgcctgacg gccagtccct ccccccaggc aggactaaga      780

agcccattgc gggagtgatc ggtcccggct ccagctctgt agccattcaa gtgcagaacc      840

tgctccagct cttcgacatc ccccagatcg cttattcagc cacaagcatc gacctgagtg      900

acaaaacttt gtacaaatac ttcctgaggg ttgtcccttc tgacactttg caggcaaggg      960

ccatgcttga catagtcaaa cgttacaatt ggacctatgt ctctgcagtc cacacggaag     1020

ggaattatgg ggagagcgga atggacgctt tcaaagagct ggctgcccag gaaggcctct     1080

gtatcgccca ttctgacaaa atctacagca acgctgggga gaagagcttt gaccgactct     1140

tgcgcaaact ccgagagagg cttcccaagg ctagagtggt ggtctgcttc tgtgaaggca     1200

tgacagtgcg aggactcctg agcgccatgc ggcgccttgg cgtcgtgggc gagttctcac     1260

tcattggaag tgatggatgg gcagacagag atgaagtcat tgaaggttat gaggtggaag     1320

ccaacggggg aatcacgata aagctgcagt ctccagaggt caggtcattt gatgattatt     1380

tcctgaaact gaggctggac actaacacga ggaatccctg gttccctgag ttctggcaac     1440

atcggttcca gtgccgcctt ccaggacacc ttctggaaaa tcccaacttt aaacgaatct     1500

gcacaggcaa tgaaagctta gaagaaaact atgtccagga cagtaagatg gggtttgtca     1560

tcaatgccat ctatgccatg gcacatgggc tgcagaacat gcaccatgcc ctctgccctg     1620

gccacgtggg cctctgcgat gccatgaagc ccatcgacgg cagcaagctg ctggacttcc     1680

tcatcaagtc ctcattcatt ggagtatctg gagaggaggt gtggtttgat gagaaaggag     1740

acgctcctgg aaggtatgat atcatgaatc tgcagtacac tgaagctaat cgctatgact     1800

atgtgcacgt tggaacctgg catgaaggag tgctgaacat tgatgattac aaaatccaga     1860

tgaacaagag tggagtggtg cggtctgtgt gcagtgagcc ttgcttaaag ggccagatta     1920

aggttatacg gaaaggagaa gtgagctgct gctggatttg cacggcctgc aaagagaatg     1980

aatatgtgca agatgagttc acctgcaaag cttgtgactt gggatggtgg cccaatgcag     2040

atctaacagg ctgtgagccc attcctgtgc gctatcttga gtggagcaac atcgaatcca     2100

ttatagccat cgccttttca tgcctgggaa tccttgttac cttgtttgtc accctaatct     2160

ttgtactgta ccgggacaca ccagtggtca aatcctccag tcgggagctc tgctacatca     2220

tcctagctgg catcttcctt ggttatgtgt gcccattcac tctcattgcc aaacctacta     2280

ccacctcctg ctacctccag cgcctcttgg ttggcctctc ctctgcgatg tgctactctg     2340

ctttagtgac taaaaccaat cgtattgcac gcatcctggc tggcagcaag aagaagatct     2400

gcacccggaa gcccaggttc atgagtgcct gggctcaggt gatcattgcc tcaattctga     2460

ttagtgtgca actaaccctg gtggtaaccc tgatcatcat ggaaccccct atgcccattc     2520

tgtcctaccc aagtatcaag gaagtctacc ttatctgcaa taccagcaac ctgggtgtgg     2580

tggccccttt gggctacaat ggactcctca tcatgagctg tacctactat gccttcaaga     2640

cccgcaacgt gcccgccaac ttcaacgagg ccaaatatat cgcgttcacc atgtacacca     2700

cctgtatcat ctggctagct tttgtgccca tttactttgg gagcaactac aagatcatca     2760

caacttgctt tgcagtgagt ctcagtgtaa cagtggctct ggggtgcatg ttcactccca     2820

agatgtacat cattattgcc aagcctgaga ggaatgtccg cagtgccttc accacctctg     2880

atgttgtccg catgcatgtt ggcgatggca agctgccctg ccgctccaac actttcctca     2940

acatcttccg aagaaagaag gcaggggcag ggaatgccaa gtggaggaca ggtgcccaag     3000

ggacagcata tgtggcaccg cctctctgtg cacgtgaaga ccaatgagac ggcctgcaac     3060

caaacagccg tcatcaagcc cctcactaaa agttaccaag gctctggcaa gagcctgacc     3120

ttttcagata ccagcaccaa gaccctttac aacgtagagg aggaggagga tgcccagccg     3180

attcgcttta gcccgcctgg tagcccttcc atggtggtgc acaggcgcgt gccaagcgcg     3240

gcgaccactc cgcctctgcc gtcccacctg accgcagagg agacccccct cttcctggcc     3300

gaaccagccc tccccaaggg cttgccccct cctctccagc agcagcagca accccctcca     3360

cagcagaaat cgctgatgga ccagctccag ggagtggtca gcaacttcag taccgcgatc     3420

ccggattttc acgcggtgct ggcaggcccc ggtggtcccg ggaacgggct gcggtccctg     3480

tacccgcccc cgccacctcc gcagcacctg cagatgctgc cgctgcagct gagcaccttt     3540

ggggaggagc tggtctcccc gcccgcggac gacgacgacg acagcgagag gtttaagctc     3600

ctccaggagt acgtgtatga gcacgagcgg gaagggaaca cggaagaaga cgaactggaa     3660

gaggaggagg aggacctgca ggcggccagc aaactgaccc cggatgattc gcctgcgctg     3720

acgcctccgt cgcctttccg cgactcggtg gcctcgggca gctcggtgcc cagctccccc     3780

gtgtccgagt cggtgctctg cacccctccc aacgtatcct acgcctctgt cattctgcgg     3840

gactacaagc aaagctcttc caccctgtaa gggggaaggg tccacataga aaagcaagac     3900

aagccagaga tctcccacac ctccagagat gtgcaaacag ctgggaggaa aagcctggga     3960

gtggggggcc tcgtcgggag gacaggagac cgctgctgct gctgccgcta ctgctgctgc     4020

tgccttaagt aggaagagag ggaaggacac caagcaaaaa atgttccagg ccaggattcg     4080

gattcttgaa ttactcgaag ccttctctgg gaagaaaggg aattctgaca aagcacaatt     4140

ccatatggta tgtaactttt atcacaaatc aaatagtgac atcacaaaca taatgtcctc     4200

ttttgcacaa ttgtgcatag atatatatat gcccacacac actgggccat gcttgccaag     4260

gaacagccca cgtggacatg ccagtcggat catgagttca cctgatggca ttcggagtga     4320

gctggtggag ccagacagag caggtgcggg gaagggaagg gcccaggcca gacccatccc     4380

aaacggatga tgggatgatg ggacagcagc tccttgctca gaagcccttc tccccgctgg     4440

gctgacagac tcctcatctt caggagactc aggaatggag cggcacaggg gtctctcttc     4500

atccactgca acccatccag tgccagcttt gagattgcac ttgaagaaag gtgcatggac     4560

cccctgctgc tctgcagatt ccctttattt aggaaaacag gaataagagc aaaattatca     4620

ccaaaaagtg cttcatcagg cgtgctacag gaggaaggag ctagaaatag aacaatccat     4680

cagcatgaga ctttgaaaaa aaaacacatg atcagcttct catgttccat attcacttat     4740

tggcgatttg gggaaaaggc cggaacaaga gattgttacg agagtggcag aaaccctttt     4800

gtagattgac ttgtgtttgt gccaagcggg ctttccattg accttcagtt aaagaacaaa     4860

ccatgtgaca aaattgttac cttccactta ctgtagcaaa taatacctac aagttgaact     4920

tctaagatgc gtatatgtac aatttggtgc cattatttct cctacgtatt agagaaacaa     4980

atccatcttt gaatctaatg gtgtactcat agcaactatt actggtttaa atgacaaata     5040

attctatcct attgtcactg aagtccttgt aactagcgag tgaatgtgtt cctgtgtcct     5100

tgtatatgtg cgatcgtaaa atttgtgcaa tgtaatgtca aattgactgg tcaatgtcaa     5160

cctagtagtc aatctaactg caattagaaa ttgtcttttg aatatactat atatattttt     5220

tatgttccaa taatgttttg tacatcattg tcatcaatat ctacagaagc tctttgacgg     5280

tttgaatact atggctcaag gttttcatat gcagctcgga tggacatttt tcttctaaga     5340

tggaacttat ttttcagata ttttctgatg tggagatatg ttattaatga agtggtttga     5400

aaatttgtta tattaaaagt gcacaaaaac tgagagtgaa aataaaaggt acattttata     5460

agcttgcaca cattattaac acataagatt gaacaaagca tttagattat tccaggttat     5520

atcatttttt taaagatttt ccacagctac ttgagtgtct aacatacagt aacatctaac     5580

tcagctaata atttgtaaaa tctttatcaa tcacattttg ccttctttta atttttatgt     5640

tcatggactt ttattcctgt gtcttggctg tcataacttt ttatttctgc tatttgctgt     5700

tgtgtaatat ccatggacat gtaatccact tactccatct ttacaatccc tttttaccac     5760

caataaaagg atttttcttg ctgttttgat ttcttctatt atttgtggaa tgaattatac     5820

cccccttaaa tatctttgtt tatgccttat gttcagtcat attttaatat gcttccttca     5880

tattgaagct gctgatttct cagccaaaaa tcatcttaga atctttaaat atccattgca     5940

tcatttgttc agaatttaac atccattcca atgttggagg cttgtattac ttatatttca     6000

tcatattcta ttgccaagtt tagtcagttc cacaccaaga atgaactgca tttcctttaa     6060

aaattatttt aaaacacctt tattgaaaag atctcatgac tgagatgtgg actttggttc     6120

catgttttca ttgtaagaaa gcagagagcg gaaaatcaat ggctccagtg attaatagat     6180

gggtttttag taattgacaa attcatgagg gaaagcatat gatctcttta ttagtgaatc     6240

atgcttattt tttactctta atgccactaa tatacatccc taatatcaca gggcttgtgc     6300

attcagattt ttaaaaaatt aggatagata aggaaacaac ttatattcaa gtgtaagatg     6360

atatcaggtt ggtctaagac ttttggtgaa cacgttcatt caactgtgat cactttatta     6420

ctctgaatgc ctactattat cctgattatg gggtctcctg aataaataga gtattagtcc     6480

ttatgtcatc attgttcaaa attggagatg tacacataca taccctatac caagagggcc     6540

gaaactcttc accttgatgt atgttctgat acaagttgtt cagcttcttg taaatgtgtt     6600

ttccttcggc ttgttactgc cttttgtcaa ataatcttga caatgctgta taataaatat     6660

tttctattta tt                                                         6672


<210>  7
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Gly Leu Leu Leu Phe Phe Phe Pro Ala Ile Phe Leu Glu Val 
1               5                   10                  15      


Ser Leu Leu Pro Arg Ser Pro Gly Arg Lys Val Leu Leu Ala Gly Ala 
            20                  25                  30          


Ser Ser Gln Arg Ser Val Ala Arg Met Asp Gly Asp Val Ile Ile Gly 
        35                  40                  45              


Ala Leu Phe Ser Val His His Gln Pro Pro Ala Glu Lys Val Pro Glu 
    50                  55                  60                  


Arg Lys Cys Gly Glu Ile Arg Glu Gln Tyr Gly Ile Gln Arg Val Glu 
65                  70                  75                  80  


Ala Met Phe His Thr Leu Asp Lys Ile Asn Ala Asp Pro Val Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ser Glu Ile Arg Asp Ser Cys Trp His Ser 
            100                 105                 110         


Ser Val Ala Leu Glu Gln Ser Ile Glu Phe Ile Arg Asp Ser Leu Ile 
        115                 120                 125             


Ser Ile Arg Asp Glu Lys Asp Gly Ile Asn Arg Cys Leu Pro Asp Gly 
    130                 135                 140                 


Gln Ser Leu Pro Pro Gly Arg Thr Lys Lys Pro Ile Ala Gly Val Ile 
145                 150                 155                 160 


Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn Leu Leu Gln 
                165                 170                 175     


Leu Phe Asp Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser Ile Asp Leu 
            180                 185                 190         


Ser Asp Lys Thr Leu Tyr Lys Tyr Phe Leu Arg Val Val Pro Ser Asp 
        195                 200                 205             


Thr Leu Gln Ala Arg Ala Met Leu Asp Ile Val Lys Arg Tyr Asn Trp 
    210                 215                 220                 


Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly Glu Ser Gly 
225                 230                 235                 240 


Met Asp Ala Phe Lys Glu Leu Ala Ala Gln Glu Gly Leu Cys Ile Ala 
                245                 250                 255     


His Ser Asp Lys Ile Tyr Ser Asn Ala Gly Glu Lys Ser Phe Asp Arg 
            260                 265                 270         


Leu Leu Arg Lys Leu Arg Glu Arg Leu Pro Lys Ala Arg Val Val Val 
        275                 280                 285             


Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Ser Ala Met Arg 
    290                 295                 300                 


Arg Leu Gly Val Val Gly Glu Phe Ser Leu Ile Gly Ser Asp Gly Trp 
305                 310                 315                 320 


Ala Asp Arg Asp Glu Val Ile Glu Gly Tyr Glu Val Glu Ala Asn Gly 
                325                 330                 335     


Gly Ile Thr Ile Lys Leu Gln Ser Pro Glu Val Arg Ser Phe Asp Asp 
            340                 345                 350         


Tyr Phe Leu Lys Leu Arg Leu Asp Thr Asn Thr Arg Asn Pro Trp Phe 
        355                 360                 365             


Pro Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Pro Gly His Leu 
    370                 375                 380                 


Leu Glu Asn Pro Asn Phe Lys Arg Ile Cys Thr Gly Asn Glu Ser Leu 
385                 390                 395                 400 


Glu Glu Asn Tyr Val Gln Asp Ser Lys Met Gly Phe Val Ile Asn Ala 
                405                 410                 415     


Ile Tyr Ala Met Ala His Gly Leu Gln Asn Met His His Ala Leu Cys 
            420                 425                 430         


Pro Gly His Val Gly Leu Cys Asp Ala Met Lys Pro Ile Asp Gly Ser 
        435                 440                 445             


Lys Leu Leu Asp Phe Leu Ile Lys Ser Ser Phe Ile Gly Val Ser Gly 
    450                 455                 460                 


Glu Glu Val Trp Phe Asp Glu Lys Gly Asp Ala Pro Gly Arg Tyr Asp 
465                 470                 475                 480 


Ile Met Asn Leu Gln Tyr Thr Glu Ala Asn Arg Tyr Asp Tyr Val His 
                485                 490                 495     


Val Gly Thr Trp His Glu Gly Val Leu Asn Ile Asp Asp Tyr Lys Ile 
            500                 505                 510         


Gln Met Asn Lys Ser Gly Val Val Arg Ser Val Cys Ser Glu Pro Cys 
        515                 520                 525             


Leu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val Ser Cys Cys 
    530                 535                 540                 


Trp Ile Cys Thr Ala Cys Lys Glu Asn Glu Tyr Val Gln Asp Glu Phe 
545                 550                 555                 560 


Thr Cys Lys Ala Cys Asp Leu Gly Trp Trp Pro Asn Ala Asp Leu Thr 
                565                 570                 575     


Gly Cys Glu Pro Ile Pro Val Arg Tyr Leu Glu Trp Ser Asn Ile Glu 
            580                 585                 590         


Ser Ile Ile Ala Ile Ala Phe Ser Cys Leu Gly Ile Leu Val Thr Leu 
        595                 600                 605             


Phe Val Thr Leu Ile Phe Val Leu Tyr Arg Asp Thr Pro Val Val Lys 
    610                 615                 620                 


Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly Ile Phe Leu 
625                 630                 635                 640 


Gly Tyr Val Cys Pro Phe Thr Leu Ile Ala Lys Pro Thr Thr Thr Ser 
                645                 650                 655     


Cys Tyr Leu Gln Arg Leu Leu Val Gly Leu Ser Ser Ala Met Cys Tyr 
            660                 665                 670         


Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile Leu Ala Gly 
        675                 680                 685             


Ser Lys Lys Lys Ile Cys Thr Arg Lys Pro Arg Phe Met Ser Ala Trp 
    690                 695                 700                 


Ala Gln Val Ile Ile Ala Ser Ile Leu Ile Ser Val Gln Leu Thr Leu 
705                 710                 715                 720 


Val Val Thr Leu Ile Ile Met Glu Pro Pro Met Pro Ile Leu Ser Tyr 
                725                 730                 735     


Pro Ser Ile Lys Glu Val Tyr Leu Ile Cys Asn Thr Ser Asn Leu Gly 
            740                 745                 750         


Val Val Ala Pro Leu Gly Tyr Asn Gly Leu Leu Ile Met Ser Cys Thr 
        755                 760                 765             


Tyr Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe Asn Glu Ala 
    770                 775                 780                 


Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
785                 790                 795                 800 


Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile Thr Thr Cys 
                805                 810                 815     


Phe Ala Val Ser Leu Ser Val Thr Val Ala Leu Gly Cys Met Phe Thr 
            820                 825                 830         


Pro Lys Met Tyr Ile Ile Ile Ala Lys Pro Glu Arg Asn Val Arg Ser 
        835                 840                 845             


Ala Phe Thr Thr Ser Asp Val Val Arg Met His Val Gly Asp Gly Lys 
    850                 855                 860                 


Leu Pro Cys Arg Ser Asn Thr Phe Leu Asn Ile Phe Arg Arg Lys Lys 
865                 870                 875                 880 


Ala Gly Ala Gly Asn Ala Lys Trp Arg Thr Gly Ala Gln Gly Thr Ala 
                885                 890                 895     


Tyr Val Ala Pro Pro Leu Cys Ala Arg Glu Asp Gln 
            900                 905             


<210>  8
<211>  3356
<212>  DNA
<213>  Homo sapiens

<400>  8
gagcgcagag ccagcgagcc agcgagcgag cgagcgggag ccggagcctc gcgccccccg       60

ctccactccg attctctccg cgccagagcc agcgcgccag gagctgggtc ccttcgcatc      120

tctcttcttg tctgtccttt cctggtccct gtttcctcct ctctttgcct tcgctgcttc      180

taatctcatc ccctggagac ccaggtctgc gggacccatc catccccttt ggggccatgg      240

gatcgctgct tgcgctcctg gcactgctgc tgctgtgggg tgctgtggct gagggcccag      300

ccaagaaggt gctgaccctg gagggagact tggtgctggg tgggctgttc ccagtgcacc      360

agaagggcgg cccagcagag gactgtggtc ctgtcaatga gcaccgtggc atccagcgcc      420

tggaggccat gctttttgca ctggaccgca tcaaccgtga cccgcacctg ctgcctggcg      480

tgcgcctggg tgcacacatc ctcgacagtt gctccaagga cacacatgcg ctggagcagg      540

cactggactt tgtgcgtgcc tcactcagcc gtggtgctga tggctcacgc cacatctgcc      600

ccgacggctc ttatgcgacc catggtgatg ctcccactgc catcactggt gttattggcg      660

gttcctacag tgatgtctcc atccaggtgg ccaacctctt gaggctattt cagatcccac      720

agattagcta cgcctctacc agtgccaagc tgagtgacaa gtcccgctat gactactttg      780

cccgcacagt gcctcctgac ttcttccaag ccaaggccat ggctgagatt ctccgcttct      840

tcaactggac ctatgtgtcc actgtggcgt ctgagggcga ctatggcgag acaggcattg      900

aggcctttga gctagaggct cgtgcccgca acatctgtgt ggccacctcg gagaaagtgg      960

gccgtgccat gagccgcgcg gcctttgagg gtgtggtgcg agccctgctg cagaagccca     1020

gtgcccgcgt ggctgtcctg ttcacccgtt ctgaggatgc ccgggagctg cttgctgcca     1080

gccagcgcct caatgccagc ttcacctggg tggccagtga tggttggggg gccctggaga     1140

gtgtggtggc aggcagtgag ggggctgctg agggtgctat caccatcgag ctggcctcct     1200

accccatcag tgactttgcc tcctacttcc agagcctgga cccttggaac aacagccgga     1260

acccctggtt ccgtgaattc tgggagcaga ggttccgctg cagcttccgg cagcgagact     1320

gcgcagccca ctctctccgg gctgtgccct ttgagcagga gtccaagatc atgtttgtgg     1380

tcaatgcagt gtacgccatg gcccatgcgc tccacaacat gcaccgtgcc ctctgcccca     1440

acaccacccg gctctgtgac gcgatgcggc cagttaacgg gcgccgcctc tacaaggact     1500

ttgtgctcaa cgtcaagttt gatgccccct ttcgcccagc tgacacccac aatgaggtcc     1560

gctttgaccg ctttggtgat ggtattggcc gctacaacat cttcacctat ctgcgtgcag     1620

gcagtgggcg ctatcgctac cagaaggtgg gctactgggc agaaggcttg actctggaca     1680

ccagcctcat cccatgggcc tcaccctcag ccggccccct gcccgcctct cgctgcagtg     1740

agccctgcct ccagaatgag gtgaagagtg tgcagccggg cgaagtctgc tgctggctct     1800

gcattccgtg ccagccctat gagtaccgat tggacgaatt cacttgcgct gattgtggcc     1860

tgggctactg gcccaatgcc agcctgactg gctgcttcga actgccccag gagtacatcc     1920

gctggggcga tgcctgggct gtgggacctg tcaccatcgc ctgcctcggt gccctggcca     1980

ccctctttgt gctgggtgtc tttgtgcggc acaatgccac accagtggtc aaggcctcag     2040

gtcgggagct ctgctacatc ctgctgggtg gtgtcttcct ctgctactgc atgaccttca     2100

tcttcattgc caagccatcc acggcagtgt gtaccttacg gcgtcttggt ttgggcactg     2160

ccttctctgt ctgctactca gccctgctca ccaagaccaa ccgcattgca cgcatcttcg     2220

gtggggcccg ggagggtgcc cagcggccac gcttcatcag tcctgcctca caggtggcca     2280

tctgcctggc acttatctcg ggccagctgc tcatcgtggt cgcctggctg gtggtggagg     2340

caccgggcac aggcaaggag acagcccccg aacggcggga ggtggtgaca ctgcgctgca     2400

accaccgcga tgcaagtatg ttgggctcgc tggcctacaa tgtgctcctc atcgcgctct     2460

gcacgcttta tgccttcaag actcgcaagt gccccgaaaa cttcaacgag gccaagttca     2520

ttggcttcac catgtacacc acctgcatca tctggctggc attcctgccc atcttctatg     2580

tcacctccag tgactaccgg gtacagacca ccaccatgtg cgtgtcagtc agcctcagcg     2640

gctccgtggt gcttggctgc ctctttgcgc ccaagctgca catcatcctc ttccagccgc     2700

agaagaacgt ggttagccac cgggcaccca ccagccgctt tggcagtgct gctgccaggg     2760

ccagctccag ccttggccaa gggtctggct cccagtttgt ccccactgtt tgcaatggcc     2820

gtgaggtggt ggactcgaca acgtcatcgc tttgaagacc ccatactccc gccctgacac     2880

agctgctcct gggaacctag tgcagaccca cgtccagggc caggaggaag ttggctggag     2940

cactgcaata atttattacc caccctatgt ctgcccccaa agtcacttac ccacctcctt     3000

accccagctc ttcagactca gaagtcagga gccttggcca ggagcctctg cagtggccac     3060

taactgccct tgtagctgtg tttcctcctg gccaggccca gggctcagag aggagcaagc     3120

cagggttcac tctgccctgg acccgggtgg ctgaggacgg caggccccag tcctaaccag     3180

caaaggtgct tccagcccag cccctccccc caactagggc cttttttatt ttttatataa     3240

gttactctgg gatggggagg gtggttattg tgggggctgc ccctccccct gcacagtagt     3300

ttgtcctgtg gtttattttg tattacctgt aaataaagtg gctttatttt aaaaaa         3356


<210>  9
<211>  872
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Ser Leu Leu Ala Leu Leu Ala Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Glu Gly Pro Ala Lys Lys Val Leu Thr Leu Glu Gly Asp Leu 
            20                  25                  30          


Val Leu Gly Gly Leu Phe Pro Val His Gln Lys Gly Gly Pro Ala Glu 
        35                  40                  45              


Asp Cys Gly Pro Val Asn Glu His Arg Gly Ile Gln Arg Leu Glu Ala 
    50                  55                  60                  


Met Leu Phe Ala Leu Asp Arg Ile Asn Arg Asp Pro His Leu Leu Pro 
65                  70                  75                  80  


Gly Val Arg Leu Gly Ala His Ile Leu Asp Ser Cys Ser Lys Asp Thr 
                85                  90                  95      


His Ala Leu Glu Gln Ala Leu Asp Phe Val Arg Ala Ser Leu Ser Arg 
            100                 105                 110         


Gly Ala Asp Gly Ser Arg His Ile Cys Pro Asp Gly Ser Tyr Ala Thr 
        115                 120                 125             


His Gly Asp Ala Pro Thr Ala Ile Thr Gly Val Ile Gly Gly Ser Tyr 
    130                 135                 140                 


Ser Asp Val Ser Ile Gln Val Ala Asn Leu Leu Arg Leu Phe Gln Ile 
145                 150                 155                 160 


Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala Lys Leu Ser Asp Lys Ser 
                165                 170                 175     


Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro Pro Asp Phe Phe Gln Ala 
            180                 185                 190         


Lys Ala Met Ala Glu Ile Leu Arg Phe Phe Asn Trp Thr Tyr Val Ser 
        195                 200                 205             


Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu Thr Gly Ile Glu Ala Phe 
    210                 215                 220                 


Glu Leu Glu Ala Arg Ala Arg Asn Ile Cys Val Ala Thr Ser Glu Lys 
225                 230                 235                 240 


Val Gly Arg Ala Met Ser Arg Ala Ala Phe Glu Gly Val Val Arg Ala 
                245                 250                 255     


Leu Leu Gln Lys Pro Ser Ala Arg Val Ala Val Leu Phe Thr Arg Ser 
            260                 265                 270         


Glu Asp Ala Arg Glu Leu Leu Ala Ala Ser Gln Arg Leu Asn Ala Ser 
        275                 280                 285             


Phe Thr Trp Val Ala Ser Asp Gly Trp Gly Ala Leu Glu Ser Val Val 
    290                 295                 300                 


Ala Gly Ser Glu Gly Ala Ala Glu Gly Ala Ile Thr Ile Glu Leu Ala 
305                 310                 315                 320 


Ser Tyr Pro Ile Ser Asp Phe Ala Ser Tyr Phe Gln Ser Leu Asp Pro 
                325                 330                 335     


Trp Asn Asn Ser Arg Asn Pro Trp Phe Arg Glu Phe Trp Glu Gln Arg 
            340                 345                 350         


Phe Arg Cys Ser Phe Arg Gln Arg Asp Cys Ala Ala His Ser Leu Arg 
        355                 360                 365             


Ala Val Pro Phe Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala 
    370                 375                 380                 


Val Tyr Ala Met Ala His Ala Leu His Asn Met His Arg Ala Leu Cys 
385                 390                 395                 400 


Pro Asn Thr Thr Arg Leu Cys Asp Ala Met Arg Pro Val Asn Gly Arg 
                405                 410                 415     


Arg Leu Tyr Lys Asp Phe Val Leu Asn Val Lys Phe Asp Ala Pro Phe 
            420                 425                 430         


Arg Pro Ala Asp Thr His Asn Glu Val Arg Phe Asp Arg Phe Gly Asp 
        435                 440                 445             


Gly Ile Gly Arg Tyr Asn Ile Phe Thr Tyr Leu Arg Ala Gly Ser Gly 
    450                 455                 460                 


Arg Tyr Arg Tyr Gln Lys Val Gly Tyr Trp Ala Glu Gly Leu Thr Leu 
465                 470                 475                 480 


Asp Thr Ser Leu Ile Pro Trp Ala Ser Pro Ser Ala Gly Pro Leu Pro 
                485                 490                 495     


Ala Ser Arg Cys Ser Glu Pro Cys Leu Gln Asn Glu Val Lys Ser Val 
            500                 505                 510         


Gln Pro Gly Glu Val Cys Cys Trp Leu Cys Ile Pro Cys Gln Pro Tyr 
        515                 520                 525             


Glu Tyr Arg Leu Asp Glu Phe Thr Cys Ala Asp Cys Gly Leu Gly Tyr 
    530                 535                 540                 


Trp Pro Asn Ala Ser Leu Thr Gly Cys Phe Glu Leu Pro Gln Glu Tyr 
545                 550                 555                 560 


Ile Arg Trp Gly Asp Ala Trp Ala Val Gly Pro Val Thr Ile Ala Cys 
                565                 570                 575     


Leu Gly Ala Leu Ala Thr Leu Phe Val Leu Gly Val Phe Val Arg His 
            580                 585                 590         


Asn Ala Thr Pro Val Val Lys Ala Ser Gly Arg Glu Leu Cys Tyr Ile 
        595                 600                 605             


Leu Leu Gly Gly Val Phe Leu Cys Tyr Cys Met Thr Phe Ile Phe Ile 
    610                 615                 620                 


Ala Lys Pro Ser Thr Ala Val Cys Thr Leu Arg Arg Leu Gly Leu Gly 
625                 630                 635                 640 


Thr Ala Phe Ser Val Cys Tyr Ser Ala Leu Leu Thr Lys Thr Asn Arg 
                645                 650                 655     


Ile Ala Arg Ile Phe Gly Gly Ala Arg Glu Gly Ala Gln Arg Pro Arg 
            660                 665                 670         


Phe Ile Ser Pro Ala Ser Gln Val Ala Ile Cys Leu Ala Leu Ile Ser 
        675                 680                 685             


Gly Gln Leu Leu Ile Val Val Ala Trp Leu Val Val Glu Ala Pro Gly 
    690                 695                 700                 


Thr Gly Lys Glu Thr Ala Pro Glu Arg Arg Glu Val Val Thr Leu Arg 
705                 710                 715                 720 


Cys Asn His Arg Asp Ala Ser Met Leu Gly Ser Leu Ala Tyr Asn Val 
                725                 730                 735     


Leu Leu Ile Ala Leu Cys Thr Leu Tyr Ala Phe Lys Thr Arg Lys Cys 
            740                 745                 750         


Pro Glu Asn Phe Asn Glu Ala Lys Phe Ile Gly Phe Thr Met Tyr Thr 
        755                 760                 765             


Thr Cys Ile Ile Trp Leu Ala Phe Leu Pro Ile Phe Tyr Val Thr Ser 
    770                 775                 780                 


Ser Asp Tyr Arg Val Gln Thr Thr Thr Met Cys Val Ser Val Ser Leu 
785                 790                 795                 800 


Ser Gly Ser Val Val Leu Gly Cys Leu Phe Ala Pro Lys Leu His Ile 
                805                 810                 815     


Ile Leu Phe Gln Pro Gln Lys Asn Val Val Ser His Arg Ala Pro Thr 
            820                 825                 830         


Ser Arg Phe Gly Ser Ala Ala Ala Arg Ala Ser Ser Ser Leu Gly Gln 
        835                 840                 845             


Gly Ser Gly Ser Gln Phe Val Pro Thr Val Cys Asn Gly Arg Glu Val 
    850                 855                 860                 


Val Asp Ser Thr Thr Ser Ser Leu 
865                 870         


<210>  10
<211>  4260
<212>  DNA
<213>  Homo sapiens

<400>  10
gtgcagttga gtcgcgagta cggctgagct gcgtaccggc ctccctggct ctcacactcc       60

ctctctgctc ccgctctcct aatctcctct ggcatgcggt cagccccctg cccagggacc      120

acaggagagt tcttgtaagg actgttagtc cctgcttacc tgaaagccaa gcgctctagc      180

agagctttaa agttggagcc gccaccctcc ctaccgcccc atgccccttc accccactcc      240

gaaattcacc gacctttgca tgcactgcct aaggatttca gagtgaggca aagcagtcgg      300

caaatctacc ctggcttttc gtataaaaat cctctcgtct aggtaccctg gctcactgaa      360

gactctgcag atataccctt ataagaggga gggtggggga gggaaaagaa cgagagaggg      420

aggaaagaat gaaaaggaga ggatgccagg aggtccgtgc ttctgccaag agtcccaatt      480

agatgcgacg gcttcagcct ggtcaaggtg aaggaaagtt gcttccgcgc ctaggaagtg      540

ggtttgcctg ataagagaag gaggagggga ctcggctggg aagagctccc ctcccctccg      600

cggaagacca ctgggtcccc tctttcccca acctcctccc tctcttctac tccacccctc      660

cgttttccca ctccccactg actcggatgc ctggatgttc tgccaccggg cagtggtcca      720

gcgtgcagcc gggagggggc aggggcaggg ggcactgtga caggaagctg cgcgcacaag      780

ttggccattt cgagggcaaa ataagttctc ccttggattt ggaaaggaca aagccagtaa      840

gctacctctt ttgtgtcgga tgaggaggac caaccatgag ccagagcccg ggtgcaggct      900

caccgccgcc gctgccaccg cggtcagctc cagttcctgc caggagttgt cggtgcgagg      960

aattttgtga caggctctgt tagtctgttc ctcccttatt tgaaggacag gccaaagatc     1020

cagtttggaa atgagagagg actagcatga cacattggct ccaccattga tatctcccag     1080

aggtacagaa acaggattca tgaagatgtt gacaagactg caagttctta ccttagcttt     1140

gttttcaaag ggatttttac tctctttagg ggaccataac tttctaagga gagagattaa     1200

aatagaaggt gaccttgttt tagggggcct gtttcctatt aacgaaaaag gcactggaac     1260

tgaagaatgt gggcgaatca atgaagaccg agggattcaa cgcctggaag ccatgttgtt     1320

tgctattgat gaaatcaaca aagatgatta cttgctacca ggagtgaagt tgggtgttca     1380

cattttggat acatgttcaa gggataccta tgcattggag caatcactgg agtttgtcag     1440

ggcatctttg acaaaagtgg atgaagctga gtatatgtgt cctgatggat cctatgccat     1500

tcaagaaaac atcccacttc tcattgcagg ggtcattggt ggctcttata gcagtgtttc     1560

catacaggtg gcaaacctgc tgcggctctt ccagatccct cagatcagct acgcatccac     1620

cagcgccaaa ctcagtgata agtcgcgcta tgattacttt gccaggaccg tgccccccga     1680

cttctaccag gccaaagcca tggctgagat cttgcgcttc ttcaactgga cctacgtgtc     1740

cacagtagcc tccgagggtg attacgggga gacagggatc gaggccttcg agcaggaagc     1800

ccgcctgcgc aacatctgca tcgctacggc ggagaaggtg ggccgctcca acatccgcaa     1860

gtcctacgac agcgtgatcc gagaactgtt gcagaagccc aacgcgcgcg tcgtggtcct     1920

cttcatgcgc agcgacgact cgcgggagct cattgcagcc gccagccgcg ccaatgcctc     1980

cttcacctgg gtggccagcg acggctgggg cgcgcaggag agcatcatca agggcagcga     2040

gcatgtggcc tacggcgcca tcaccctgga gctggcctcc cagcctgtcc gccagttcga     2100

ccgctacttc cagagcctca acccctacaa caaccaccgc aacccctggt tccgggactt     2160

ctgggagcaa aagtttcagt gcagcctcca gaacaaacgc aaccacaggc gcgtctgcga     2220

caagcacctg gccatcgaca gcagcaacta cgagcaagag tccaagatca tgtttgtggt     2280

gaacgcggtg tatgccatgg cccacgcttt gcacaaaatg cagcgcaccc tctgtcccaa     2340

cactaccaag ctttgtgatg ctatgaagat cctggatggg aagaagttgt acaaggatta     2400

cttgctgaaa atcaacttca cggctccatt caacccaaat aaagatgcag atagcatagt     2460

caagtttgac acttttggag atggaatggg gcgatacaac gtgttcaatt tccaaaatgt     2520

aggtggaaag tattcctact tgaaagttgg tcactgggca gaaaccttat cgctagatgt     2580

caactctatc cactggtccc ggaactcagt ccccacttcc cagtgcagcg acccctgtgc     2640

ccccaatgaa atgaagaata tgcaaccagg ggatgtctgc tgctggattt gcatcccctg     2700

tgaaccctac gaatacctgg ctgatgagtt tacctgtatg gattgtgggt ctggacagtg     2760

gcccactgca gacctaactg gatgctatga ccttcctgag gactacatca ggtgggaaga     2820

cgcctgggcc attggcccag tcaccattgc ctgtctgggt tttatgtgta catgcatggt     2880

tgtaactgtt tttatcaagc acaacaacac acccttggtc aaagcatcgg gccgagaact     2940

ctgctacatc ttattgtttg gggttggcct gtcatactgc atgacattct tcttcattgc     3000

caagccatca ccagtcatct gtgcattgcg ccgactcggg ctggggagtt ccttcgctat     3060

ctgttactca gccctgctga ccaagacaaa ctgcattgcc cgcatcttcg atggggtcaa     3120

gaatggcgct cagaggccaa aattcatcag ccccagttct caggttttca tctgcctggg     3180

tctgatcctg gtgcaaattg tgatggtgtc tgtgtggctc atcctggagg ccccaggcac     3240

caggaggtat acccttgcag agaagcggga aacagtcatc ctaaaatgca atgtcaaaga     3300

ttccagcatg ttgatctctc ttacctacga tgtgatcctg gtgatcttat gcactgtgta     3360

cgccttcaaa acgcggaagt gcccagaaaa tttcaacgaa gctaagttca taggttttac     3420

catgtacacc acgtgcatca tctggttggc cttcctccct atattttatg tgacatcaag     3480

tgactacaga gtgcagacga caaccatgtg catctctgtc agcctgagtg gctttgtggt     3540

cttgggctgt ttgtttgcac ccaaggttca catcatcctg tttcaacccc agaagaatgt     3600

tgtcacacac agactgcacc tcaacaggtt cagtgtcagt ggaactggga ccacatactc     3660

tcagtcctct gcaagcacgt atgtgccaac ggtgtgcaat gggcgggaag tcctcgactc     3720

caccacctca tctctgtgat tgtgaattgc agttcagttc ttgtgttttt agactgttag     3780

acaaaagtgc tcacgtgcag ctccagaata tggaaacaga gcaaaagaac aaccctagta     3840

ccttttttta gaaacagtac gataaattat ttttgaggac tgtatatagt gatgtgctag     3900

aactttctag gctgagtcta gtgcccctat tattaacaat tcccccagaa catggaaata     3960

accattgttt acagagctga gcattggtga cagggtctga catggtcagt ctactaaaaa     4020

acaaaaaaaa aaaacaaaaa aaaaaaaaca aaagaaaaaa ataaaaatac ggtggcaata     4080

ttatgtaacc ttttttccta tgaagttttt tgtaggtcct tgttgtaact aatttaggat     4140

gagtttctat gttgtatatt aaagttacat tatgtgtaac agattgattt tctcagcaca     4200

aaataaaaag catctgtatt aatgtaaaga tactgagaat aaaaccttca aggttttcca     4260


<210>  11
<211>  879
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Lys Met Leu Thr Arg Leu Gln Val Leu Thr Leu Ala Leu Phe Ser 
1               5                   10                  15      


Lys Gly Phe Leu Leu Ser Leu Gly Asp His Asn Phe Leu Arg Arg Glu 
            20                  25                  30          


Ile Lys Ile Glu Gly Asp Leu Val Leu Gly Gly Leu Phe Pro Ile Asn 
        35                  40                  45              


Glu Lys Gly Thr Gly Thr Glu Glu Cys Gly Arg Ile Asn Glu Asp Arg 
    50                  55                  60                  


Gly Ile Gln Arg Leu Glu Ala Met Leu Phe Ala Ile Asp Glu Ile Asn 
65                  70                  75                  80  


Lys Asp Asp Tyr Leu Leu Pro Gly Val Lys Leu Gly Val His Ile Leu 
                85                  90                  95      


Asp Thr Cys Ser Arg Asp Thr Tyr Ala Leu Glu Gln Ser Leu Glu Phe 
            100                 105                 110         


Val Arg Ala Ser Leu Thr Lys Val Asp Glu Ala Glu Tyr Met Cys Pro 
        115                 120                 125             


Asp Gly Ser Tyr Ala Ile Gln Glu Asn Ile Pro Leu Leu Ile Ala Gly 
    130                 135                 140                 


Val Ile Gly Gly Ser Tyr Ser Ser Val Ser Ile Gln Val Ala Asn Leu 
145                 150                 155                 160 


Leu Arg Leu Phe Gln Ile Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala 
                165                 170                 175     


Lys Leu Ser Asp Lys Ser Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro 
            180                 185                 190         


Pro Asp Phe Tyr Gln Ala Lys Ala Met Ala Glu Ile Leu Arg Phe Phe 
        195                 200                 205             


Asn Trp Thr Tyr Val Ser Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu 
    210                 215                 220                 


Thr Gly Ile Glu Ala Phe Glu Gln Glu Ala Arg Leu Arg Asn Ile Cys 
225                 230                 235                 240 


Ile Ala Thr Ala Glu Lys Val Gly Arg Ser Asn Ile Arg Lys Ser Tyr 
                245                 250                 255     


Asp Ser Val Ile Arg Glu Leu Leu Gln Lys Pro Asn Ala Arg Val Val 
            260                 265                 270         


Val Leu Phe Met Arg Ser Asp Asp Ser Arg Glu Leu Ile Ala Ala Ala 
        275                 280                 285             


Ser Arg Ala Asn Ala Ser Phe Thr Trp Val Ala Ser Asp Gly Trp Gly 
    290                 295                 300                 


Ala Gln Glu Ser Ile Ile Lys Gly Ser Glu His Val Ala Tyr Gly Ala 
305                 310                 315                 320 


Ile Thr Leu Glu Leu Ala Ser Gln Pro Val Arg Gln Phe Asp Arg Tyr 
                325                 330                 335     


Phe Gln Ser Leu Asn Pro Tyr Asn Asn His Arg Asn Pro Trp Phe Arg 
            340                 345                 350         


Asp Phe Trp Glu Gln Lys Phe Gln Cys Ser Leu Gln Asn Lys Arg Asn 
        355                 360                 365             


His Arg Arg Val Cys Asp Lys His Leu Ala Ile Asp Ser Ser Asn Tyr 
    370                 375                 380                 


Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala Val Tyr Ala Met 
385                 390                 395                 400 


Ala His Ala Leu His Lys Met Gln Arg Thr Leu Cys Pro Asn Thr Thr 
                405                 410                 415     


Lys Leu Cys Asp Ala Met Lys Ile Leu Asp Gly Lys Lys Leu Tyr Lys 
            420                 425                 430         


Asp Tyr Leu Leu Lys Ile Asn Phe Thr Ala Pro Phe Asn Pro Asn Lys 
        435                 440                 445             


Asp Ala Asp Ser Ile Val Lys Phe Asp Thr Phe Gly Asp Gly Met Gly 
    450                 455                 460                 


Arg Tyr Asn Val Phe Asn Phe Gln Asn Val Gly Gly Lys Tyr Ser Tyr 
465                 470                 475                 480 


Leu Lys Val Gly His Trp Ala Glu Thr Leu Ser Leu Asp Val Asn Ser 
                485                 490                 495     


Ile His Trp Ser Arg Asn Ser Val Pro Thr Ser Gln Cys Ser Asp Pro 
            500                 505                 510         


Cys Ala Pro Asn Glu Met Lys Asn Met Gln Pro Gly Asp Val Cys Cys 
        515                 520                 525             


Trp Ile Cys Ile Pro Cys Glu Pro Tyr Glu Tyr Leu Ala Asp Glu Phe 
    530                 535                 540                 


Thr Cys Met Asp Cys Gly Ser Gly Gln Trp Pro Thr Ala Asp Leu Thr 
545                 550                 555                 560 


Gly Cys Tyr Asp Leu Pro Glu Asp Tyr Ile Arg Trp Glu Asp Ala Trp 
                565                 570                 575     


Ala Ile Gly Pro Val Thr Ile Ala Cys Leu Gly Phe Met Cys Thr Cys 
            580                 585                 590         


Met Val Val Thr Val Phe Ile Lys His Asn Asn Thr Pro Leu Val Lys 
        595                 600                 605             


Ala Ser Gly Arg Glu Leu Cys Tyr Ile Leu Leu Phe Gly Val Gly Leu 
    610                 615                 620                 


Ser Tyr Cys Met Thr Phe Phe Phe Ile Ala Lys Pro Ser Pro Val Ile 
625                 630                 635                 640 


Cys Ala Leu Arg Arg Leu Gly Leu Gly Ser Ser Phe Ala Ile Cys Tyr 
                645                 650                 655     


Ser Ala Leu Leu Thr Lys Thr Asn Cys Ile Ala Arg Ile Phe Asp Gly 
            660                 665                 670         


Val Lys Asn Gly Ala Gln Arg Pro Lys Phe Ile Ser Pro Ser Ser Gln 
        675                 680                 685             


Val Phe Ile Cys Leu Gly Leu Ile Leu Val Gln Ile Val Met Val Ser 
    690                 695                 700                 


Val Trp Leu Ile Leu Glu Ala Pro Gly Thr Arg Arg Tyr Thr Leu Ala 
705                 710                 715                 720 


Glu Lys Arg Glu Thr Val Ile Leu Lys Cys Asn Val Lys Asp Ser Ser 
                725                 730                 735     


Met Leu Ile Ser Leu Thr Tyr Asp Val Ile Leu Val Ile Leu Cys Thr 
            740                 745                 750         


Val Tyr Ala Phe Lys Thr Arg Lys Cys Pro Glu Asn Phe Asn Glu Ala 
        755                 760                 765             


Lys Phe Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
    770                 775                 780                 


Phe Leu Pro Ile Phe Tyr Val Thr Ser Ser Asp Tyr Arg Val Gln Thr 
785                 790                 795                 800 


Thr Thr Met Cys Ile Ser Val Ser Leu Ser Gly Phe Val Val Leu Gly 
                805                 810                 815     


Cys Leu Phe Ala Pro Lys Val His Ile Ile Leu Phe Gln Pro Gln Lys 
            820                 825                 830         


Asn Val Val Thr His Arg Leu His Leu Asn Arg Phe Ser Val Ser Gly 
        835                 840                 845             


Thr Gly Thr Thr Tyr Ser Gln Ser Ser Ala Ser Thr Tyr Val Pro Thr 
    850                 855                 860                 


Val Cys Asn Gly Arg Glu Val Leu Asp Ser Thr Thr Ser Ser Leu 
865                 870                 875                 


<210>  12
<211>  3201
<212>  DNA
<213>  Homo sapiens

<400>  12
gcagtgtgca gttgagtcgc gagtacggct gagctgcgta ccggcctccc tggctctcac       60

actccctctc tgctcccgct ctcctaatct cctctggcat gcggtcagcc ccctgcccag      120

ggaccacagg agagttcttg taaggactgt tagtccctgc ttacctgaaa gccaagcgct      180

ctagcagagc tttaaagttg gagccgccac cctccctacc gccccatgcc ccttcacccc      240

actccgaaat tcaccgacct ttgcatgcac tgcctaagga tttcagagtg aggcaaagca      300

gtcggcaaat ctaccctggc ttttcgtata aaaatcctct cgtctaggta ccctggctca      360

ctgaagactc tgcagatata cccttataag agggagggtg ggggagggaa aagaacgaga      420

gagggaggaa agaatgaaaa ggagaggatg ccaggaggtc cgtgcttctg ccaagagtcc      480

caattagatg cgacggcttc agcctggtca aggtgaagga aagttgcttc cgcgcctagg      540

aagtgggttt gcctgataag agaaggagga ggggactcgg ctgggaagag ctcccctccc      600

ctccgcggaa gaccactggg tcccctcttt ccccaacctc ctccctctct tctactccac      660

ccctccgttt tcccactccc cactgactcg gatgcctgga tgttctgcca ccgggcagtg      720

gtccagcgtg cagccgggag ggggcagggg cagggggcac tgtgacagga agctgcgcgc      780

acaagttggc catttcgagg gcaaaataag ttctcccttg gatttggaaa ggacaaagcc      840

agtaagctac ctcttttgtg tcggatgagg aggaccaacc atgagccaga gcccgggtgc      900

aggctcaccg ccgccgctgc caccgcggtc agctccagtt cctgccagga gttgtcggtg      960

cgaggaattt tgtgacaggc tctgttagtc tgttcctccc ttatttgaag gacaggccaa     1020

agatccagtt tggaaatgag agaggactag catgacacat tggctccacc attgatatct     1080

cccagaggta cagaaacagg attcatgaag atgttgacaa gactgcaagt tcttacctta     1140

gctttgtttt caaagggatt tttactctct ttaggggacc ataactttct aaggagagag     1200

attaaaatag aaggtgacct tgttttaggg ggcctgtttc ctattaacga aaaaggcact     1260

ggaactgaag aatgtgggcg aatcaatgaa gaccgaggga ttcaacgcct ggaagccatg     1320

ttgtttgcta ttgatgaaat caacaaagat gattacttgc taccaggagt gaagttgggt     1380

gttcacattt tggatacatg ttcaagggat acctatgcat tggagcaatc actggagttt     1440

gtcagggcat ctttgacaaa agtggatgaa gctgagtata tgtgtcctga tggatcctat     1500

gccattcaag aaaacatccc acttctcatt gcaggggtca ttggtggctc ttatagcagt     1560

gtttccatac aggtggcaaa cctgctgcgg ctcttccaga tccctcagat cagctacgca     1620

tccaccagcg ccaaactcag tgataagtcg cgctatgatt actttgccag gaccgtgccc     1680

cccgacttct accaggccaa agccatggct gagatcttgc gcttcttcaa ctggacctac     1740

gtgtccacag tagcctccga gggtgattac ggggagacag ggatcgaggc cttcgagcag     1800

gaagcccgcc tgcgcaacat ctgcatcgct acggcggaga aggtgggccg ctccaacatc     1860

cgcaagtcct acgacagcgt gatccgagaa ctgttgcaga agcccaacgc gcgcgtcgtg     1920

gtcctcttca tgcgcagcga cgactcgcgg gagctcattg cagccgccag ccgcgccaat     1980

gcctccttca cctgggtggc cagcgacggc tggggcgcgc aggagagcat catcaagggc     2040

agcgagcatg tggcctacgg cgccatcacc ctggagctgg cctcccagcc tgtccgccag     2100

ttcgaccgct acttccagag cctcaacccc tacaacaacc accgcaaccc ctggttccgg     2160

gacttctggg agcaaaagtt tcagtgcagc ctccagaaca aacgcaacca caggcgcgtc     2220

tgcgacaagc acctggccat cgacagcagc aactacgagc aagagtccaa gatcatgttt     2280

gtggtgaacg cggtgtatgc catggcccac gctttgcaca aaatgcagcg caccctctgt     2340

cccaacacta ccaagctttg tgatgctatg aagatcctgg atgggaagaa gttgtacaag     2400

gattacttgc tgaaaatcaa cttcacgggt gcagacgaca accatgtgca tctctgtcag     2460

cctgagtggc tttgtggtct tgggctgttt gtttgcaccc aaggttcaca tcatcctgtt     2520

tcaaccccag aagaatgttg tcacacacag actgcacctc aacaggttca gtgtcagtgg     2580

aactgggacc acatactctc agtcctctgc aagcacgtat gtgccaacgg tgtgcaatgg     2640

gcgggaagtc ctcgactcca ccacctcatc tctgtgattg tgaattgcag ttcagttctt     2700

gtgtttttag actgttagac aaaagtgctc acgtgcagct ccagaatatg gaaacagagc     2760

aaaagaacaa ccctagtacc tttttttaga aacagtacga taaattattt ttgaggactg     2820

tatatagtga tgtgctagaa ctttctaggc tgagtctagt gcccctatta ttaacaattc     2880

ccccagaaca tggaaataac cattgtttac agagctgagc attggtgaca gggtctgaca     2940

tggtcagtct actaaaaaac aaaaaaaaaa aacaaaaaaa aaaaaacaaa agaaaaaaat     3000

aaaaatacgg tggcaatatt atgtaacctt ttttcctatg aagttttttg taggtccttg     3060

ttgtaactaa tttaggatga gtttctatgt tgtatattaa agttacatta tgtgtaacag     3120

attgattttc tcagcacaaa ataaaaagca tctgtattaa tgtaaagata ctgagaataa     3180

aaccttcaag gttttccagc a                                               3201


<210>  13
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Lys Met Leu Thr Arg Leu Gln Val Leu Thr Leu Ala Leu Phe Ser 
1               5                   10                  15      


Lys Gly Phe Leu Leu Ser Leu Gly Asp His Asn Phe Leu Arg Arg Glu 
            20                  25                  30          


Ile Lys Ile Glu Gly Asp Leu Val Leu Gly Gly Leu Phe Pro Ile Asn 
        35                  40                  45              


Glu Lys Gly Thr Gly Thr Glu Glu Cys Gly Arg Ile Asn Glu Asp Arg 
    50                  55                  60                  


Gly Ile Gln Arg Leu Glu Ala Met Leu Phe Ala Ile Asp Glu Ile Asn 
65                  70                  75                  80  


Lys Asp Asp Tyr Leu Leu Pro Gly Val Lys Leu Gly Val His Ile Leu 
                85                  90                  95      


Asp Thr Cys Ser Arg Asp Thr Tyr Ala Leu Glu Gln Ser Leu Glu Phe 
            100                 105                 110         


Val Arg Ala Ser Leu Thr Lys Val Asp Glu Ala Glu Tyr Met Cys Pro 
        115                 120                 125             


Asp Gly Ser Tyr Ala Ile Gln Glu Asn Ile Pro Leu Leu Ile Ala Gly 
    130                 135                 140                 


Val Ile Gly Gly Ser Tyr Ser Ser Val Ser Ile Gln Val Ala Asn Leu 
145                 150                 155                 160 


Leu Arg Leu Phe Gln Ile Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala 
                165                 170                 175     


Lys Leu Ser Asp Lys Ser Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro 
            180                 185                 190         


Pro Asp Phe Tyr Gln Ala Lys Ala Met Ala Glu Ile Leu Arg Phe Phe 
        195                 200                 205             


Asn Trp Thr Tyr Val Ser Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu 
    210                 215                 220                 


Thr Gly Ile Glu Ala Phe Glu Gln Glu Ala Arg Leu Arg Asn Ile Cys 
225                 230                 235                 240 


Ile Ala Thr Ala Glu Lys Val Gly Arg Ser Asn Ile Arg Lys Ser Tyr 
                245                 250                 255     


Asp Ser Val Ile Arg Glu Leu Leu Gln Lys Pro Asn Ala Arg Val Val 
            260                 265                 270         


Val Leu Phe Met Arg Ser Asp Asp Ser Arg Glu Leu Ile Ala Ala Ala 
        275                 280                 285             


Ser Arg Ala Asn Ala Ser Phe Thr Trp Val Ala Ser Asp Gly Trp Gly 
    290                 295                 300                 


Ala Gln Glu Ser Ile Ile Lys Gly Ser Glu His Val Ala Tyr Gly Ala 
305                 310                 315                 320 


Ile Thr Leu Glu Leu Ala Ser Gln Pro Val Arg Gln Phe Asp Arg Tyr 
                325                 330                 335     


Phe Gln Ser Leu Asn Pro Tyr Asn Asn His Arg Asn Pro Trp Phe Arg 
            340                 345                 350         


Asp Phe Trp Glu Gln Lys Phe Gln Cys Ser Leu Gln Asn Lys Arg Asn 
        355                 360                 365             


His Arg Arg Val Cys Asp Lys His Leu Ala Ile Asp Ser Ser Asn Tyr 
    370                 375                 380                 


Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala Val Tyr Ala Met 
385                 390                 395                 400 


Ala His Ala Leu His Lys Met Gln Arg Thr Leu Cys Pro Asn Thr Thr 
                405                 410                 415     


Lys Leu Cys Asp Ala Met Lys Ile Leu Asp Gly Lys Lys Leu Tyr Lys 
            420                 425                 430         


Asp Tyr Leu Leu Lys Ile Asn Phe Thr Gly Ala Asp Asp Asn His Val 
        435                 440                 445             


His Leu Cys Gln Pro Glu Trp Leu Cys Gly Leu Gly Leu Phe Val Cys 
    450                 455                 460                 


Thr Gln Gly Ser His His Pro Val Ser Thr Pro Glu Glu Cys Cys His 
465                 470                 475                 480 


Thr Gln Thr Ala Pro Gln Gln Val Gln Cys Gln Trp Asn Trp Asp His 
                485                 490                 495     


Ile Leu Ser Val Leu Cys Lys His Val Cys Ala Asn Gly Val Gln Trp 
            500                 505                 510         


Ala Gly Ser Pro Arg Leu His His Leu Ile Ser Val Ile Val Asn Cys 
        515                 520                 525             


Ser Ser Val Leu Val Phe Leu Asp Cys 
    530                 535         


<210>  14
<211>  7368
<212>  DNA
<213>  Homo sapiens

<400>  14
gctgtacttt tctgggtgtg tgttagggag gctatgttcc tgaccctccc cctctggggt       60

gagaaggggt ccccgccatg tcctcggggt tggtaggagg agaggattgg agctgttttc      120

tccttgatgc caagatacgc caagctagga gcattctgcc ctttccacag tcatccaccg      180

agaacaggcc tgcaggacgg gacaaggatc agagccttcc tgcaaccccg gccactgcct      240

gctgtctgtg ggcctggact gtgcgggcaa ctgtgcttgg cccgagtgac aaggaggtgg      300

gagagggtag cagcatgggc tacgcggttg gctgccctca gtccccctgc tgctgaagct      360

gccctgccca tgcccaccca ggccgtgggg ccaggggcct gccagggcta ggagtgggcc      420

tgccgttcat gggtctctag ggatttccga gatgcctggg aagagaggct tgggctggtg      480

gtgggcccgg ctgccccttt gcctgctcct cagcctttac ggcccctgga tgccttcctc      540

cctgggaaag cccaaaggcc accctcacat gaattccatc cgcatagatg gggacatcac      600

actgggaggc ctgttcccgg tgcatggccg gggctcagag ggcaagccct gtggagaact      660

taagaaggaa aagggcatcc accggctgga ggccatgctg ttcgccctgg atcgcatcaa      720

caacgacccg gacctgctgc ctaacatcac gctgggcgcc cgcattctgg acacctgctc      780

cagggacacc catgccctcg agcagtcgct gacctttgtg caggcgctca tcgagaagga      840

tggcacagag gtccgctgtg gcagtggcgg cccacccatc atcaccaagc ctgaacgtgt      900

ggtgggtgtc atcggtgctt cagggagctc ggtctccatc atggtggcca acatccttcg      960

cctcttcaag ataccccaga tcagctacgc ctccacagcg ccagacctga gtgacaacag     1020

ccgctacgac ttcttctccc gcgtggtgcc ctcggacacg taccaggccc aggccatggt     1080

ggacatcgtc cgtgccctca agtggaacta tgtgtccaca gtggcctcgg agggcagcta     1140

tggtgagagc ggtgtggagg ccttcatcca gaagtcccgt gaggacgggg gcgtgtgcat     1200

cgcccagtcg gtgaagatac cacgggagcc caaggcaggc gagttcgaca agatcatccg     1260

ccgcctcctg gagacttcga acgccagggc agtcatcatc tttgccaacg aggatgacat     1320

caggcgtgtg ctggaggcag cacgaagggc caaccagaca ggccatttct tctggatggg     1380

ctctgacagc tggggctcca agattgcacc tgtgctgcac ctggaggagg tggctgaggg     1440

tgctgtcacg atcctcccca agaggatgtc cgtacgaggc ttcgaccgct acttctccag     1500

ccgcacgctg gacaacaacc ggcgcaacat ctggtttgcc gagttctggg aggacaactt     1560

ccactgcaag ctgagccgcc acgccctcaa gaagggcagc cacgtcaaga agtgcaccaa     1620

ccgtgagcga attgggcagg attcagctta tgagcaggag gggaaggtgc agtttgtgat     1680

cgatgccgtg tacgccatgg gccacgcgct gcacgccatg caccgtgacc tgtgtcccgg     1740

ccgcgtgggg ctctgcccgc gcatggaccc tgtagatggc acccagctgc ttaagtacat     1800

ccgaaacgtc aacttctcag gcatcgcagg gaaccctgtg accttcaatg agaatggaga     1860

tgcgcctggg cgctatgaca tctaccaata ccagctgcgc aacgattctg ccgagtacaa     1920

ggtcattggc tcctggactg accacctgca ccttagaata gagcggatgc actggccggg     1980

gagcgggcag cagctgcccc gctccatctg cagcctgccc tgccaaccgg gtgagcggaa     2040

gaagacagtg aagggcatgc cttgctgctg gcactgcgag ccttgcacag ggtaccagta     2100

ccaggtggac cgctacacct gtaagacgtg tccctatgac atgcggccca cagagaaccg     2160

cacgggctgc cggcccatcc ccatcatcaa gcttgagtgg ggctcgccct gggccgtgct     2220

gcccctcttc ctggccgtgg tgggcatcgc tgccacgttg ttcgtggtga tcacctttgt     2280

gcgctacaac gacacgccca tcgtcaaggc ctcgggccgt gaactgagct acgtgctgct     2340

ggcaggcatc ttcctgtgct atgccaccac cttcctcatg atcgctgagc ccgaccttgg     2400

cacctgctcg ctgcgccgaa tcttcctggg actagggatg agcatcagct atgcagccct     2460

gctcaccaag accaaccgca tctaccgcat cttcgagcag ggcaagcgct cggtcagtgc     2520

cccacgcttc atcagccccg cctcacagct ggccatcacc ttcagcctca tctcgctgca     2580

gctgctgggc atctgtgtgt ggtttgtggt ggacccctcc cactcggtgg tggacttcca     2640

ggaccagcgg acactcgacc cccgcttcgc caggggtgtg ctcaagtgtg acatctcgga     2700

cctgtcgctc atctgcctgc tgggctacag catgctgctc atggtcacgt gcaccgtgta     2760

tgccatcaag acacgcggcg tgcccgagac cttcaatgag gccaagccca ttggcttcac     2820

catgtacacc acttgcatcg tctggctggc cttcatcccc atcttctttg gcacctcgca     2880

gtcggccgac aagctgtaca tccagacgac gacgctgacg gtctcggtga gtctgagcgc     2940

ctcggtgtcc ctgggaatgc tctacatgcc caaagtctac atcatcctct tccacccgga     3000

gcagaacgtg cccaagcgca agcgcagcct caaagccgtc gttacggcgg ccaccatgtc     3060

caacaagttc acgcagaagg gcaacttccg gcccaacgga gaggccaagt ctgagctctg     3120

cgagaacctt gaggccccag cgctggccac caaacagact tacgtcactt acaccaacca     3180

tgcaatctag cgagtccatg gagctgagca gcaggaggag gagccgtgac cctgtggaag     3240

gtgcgtcggg ccagggccac acccaagggc ccagctgtct tgcctgcccg tgggcaccca     3300

cggacgtggc ttggtgctga ggatagcaga gcccccagcc atcactgctg gcagcctggg     3360

caaaccgggt gagcaacagg aggacgaggg gccggggcgg tgccaggcta ccacaagaac     3420

ctgcgtcttg gaccattgcc cctcccggcc ccaaaccaca ggggctcagg tcgtgtgggc     3480

cccagtgcta gatctctccc tcccttcgtc tctgtctgtg ctgttggcga cccctctgtc     3540

tgtctccagc cctgtctttc tgttctctta tctctttgtt tcaccttttc cctctctggc     3600

gtccccggct gcttgtactc ttggcctttt ctgtgtctcc tttctggctc ttgcctccgc     3660

ctctctctct catcctcttt gtcctcagct cctcctgctt tcttgggtcc caccagtgtc     3720

acttttctgc cgttttcttt cctgttctcc tctgcttcat tctcgtccag ccattgctcc     3780

cctctccctg ccacccttcc ccagttcacc aaaccttaca tgttgcaaaa gagaaaaaag     3840

gaaaaaaaat caaaacacaa aaaagccaaa acgaaaacaa atctcgagtg tgttgccaag     3900

tgctgcgtcc tcctggtggc ctctgtgtgt gtccctgtgg cccgcagcct gcccgcctgc     3960

cccgcccatc tgccgtgtgt cttgcccgcc tgccccgccc gtctgccgtc tgtcttgccc     4020

gcctgcccgc ctgcccctcc tgccgaccac acggagttca gtgcctgggt gtttggtgat     4080

ggttattgac gacaatgtgt agcgcatgat tgtttttata ccaagaacat ttctaataaa     4140

aataaacaca tggttttgca cccgggctcc acatccactg agggtcctgc catgggacca     4200

caggctcagc ctgcagctgg agggcttaga cctagaggga agcgggaact gggctctgga     4260

gacccagggc ttgggggctg tggagactgc tccctaggct gggatctagt gtggtgtggt     4320

gaggccttgg gcatggaggg gccagattcc caggtaaggg gcagggacat tgcaggaaat     4380

tccaggaatc agcacctagt agtcccctaa ttagggggta tgctctgtcc cctgccctgc     4440

agccctggga gggtaacatt tctgccttgc ctgtcctctg tctcacaccc ctcacacctg     4500

ggactgccct tccacccctg cccccataac ctgtgcctct ctccttccag ccaggaagtc     4560

ctcttcttga gaagttagct tcccgggctg ccagcactca tagccgtccc ctcctgcttg     4620

tgttggctcc aggctcgggt gctaagaaga tgtgtgtctg tcctggagat cagtgtgttg     4680

ttatgtgtcc acgtgggccc acaagtgcac ggcacaggca tggccgtgtg gctgtgttgg     4740

ctgtgttggc tgtgtgtctg tgtgcacgtc cagcgcctcc atgcgcatgc gtgcctgtct     4800

tgtttgcgtg tctgatcatc tgtttgggcc ccggtggctc atgcagatgc ctgtctcagg     4860

cccatggcga gtgttcacct cagctggctt ccctggcagg ttgggaggtg ggaaacagga     4920

gcgcttaggg gctgggctct ggctggggta aattatagag ccagaaacac aatgaggcca     4980

taggcagcag ctggagcctg ggctgcctgt gccgtcccct cctgccctgc ccctgggtcc     5040

tgcaccccct cccacctcca ggctagctga cagcgctatg gagcacagtg gaagggactg     5100

gaggaaccct aggcaggggg ccacgcaggg acagagtatg agagtgtgtg tataactgag     5160

gctgggacat tgaatcatgc caggtatgtc ttctccatca gcccactctt actcctggcc     5220

tgggcatctc acacatctgt gcataggaaa tctcttcttc cctggggtct gtgtgcagca     5280

cctagtagat gctcaataaa tgtttgtgtg agggaaggag acaggaaagg aagtgtctcg     5340

ctgatcatct tgcggaatgg ttcctaagac ctctgcccag gaaagattcc acccagtgct     5400

ccagcccggt caggcagaac taggttgcca gatcaagggt atctcccaaa agcttccagg     5460

gcagttgggg gtgggggggt ggggggtagg gatggggaat gcagaagcgg gtgcagccag     5520

ctctccccca gggtgactct ggcagcaccc ccatcctggg caccctgcct gctctgtggc     5580

tcacgcccct cctgaagtga ctgatgctct gaggcccaag gctaggtcca gggcagggcc     5640

tgcaggggtt tcatgctcag tccaggactt gcctaggtcc ccctacatct gtggggcccc     5700

catctaggtt ctaacaggag aatcacctct ccaaggggga tgctgcccct cggctcccct     5760

tggctctcag gaggggccct cagggactac cagtcccctg ccagtgggaa gaaatagccc     5820

tgccctcagg gagcttccag tgtgatgggg gagatacagc agactgtgtc ccaaagtaaa     5880

atgactgtta gaatgaggtg ggtggaggag ggaagccttg ggtgggtgtg actttgggca     5940

tctgagcctg gggtgcagag gtgggctctg tgggcctgag gtggacagga gggaaccagg     6000

ccctagcaag acttttgcca gctagacctg ctgcagcagt tgggagggtg ggtgctgctg     6060

gagtcctggg tccatcacct agaaggctca ggccagtgca gccagggctg gggcccacag     6120

ctggcctggg tgggacctgc cctgatgccc atggcaggag ggacgcctgg cccttcacaa     6180

ttggcttggc tgctcacctt tgctctcatc ctcaattatt aatgactgga gaaagctgct     6240

aagtatcttc agaatgttag atttcaacaa gatggggggt tcagggtccc tggcaccctg     6300

gatagggagc cagcggcccc tagagacctt tgctgtgtgc agggggtatg tgctcacccc     6360

cgtggcctca gcctcctcaa tgtctgaatg aaggattggg ctagcagaca tcccacccca     6420

cagcacactt tctaaccagc aggggaactt ctagacaata gagacgctgg gctccctcca     6480

gaacactgga cctgaacttc tggggggagg gctgggcacg ggcatatttt aaaagctccc     6540

cagcagatgg gccgtgcagt caagtgggcc aagagtggca ccagactttg gggcttgtga     6600

agtcaggagg gagcaacagt gcccactcga gcttgcctgg ggctcaagcc caaggctggg     6660

ctgctgccag cctgagcaga cacccaggag cttccaggcc agctggatgc acagggcacc     6720

tttgtggaac tcctaggacc ctggggagac ccacctcagg agcagagtct caggtccctt     6780

ccggctctga ggggctgttc tgagctctaa tgtcttatgg tctgcccctc ccatccttac     6840

ttctcaggcc ctggaggcag aggcatagag ccaggcagga cagaggtctc agtgggccac     6900

atgccagctg cccccacact gcctcagcct ccaggcctcc aaggggtcct ggggagcccc     6960

tgagaagatg ctgagcctgc ataaggctgg gcgcccctct ttctgacacc ctcactggct     7020

ccacggctcc cccttcccat cccaggtttc catctgccca ctgaacaggg aggggaaact     7080

gaggcactcc cctggcactg agggctcctt ctgtcatcct gcctgccctg gatggtcctg     7140

gctgcccctc agggcttggc cctggcactg tgagcctcac agggctcaga cccccacccc     7200

caacccagca ctaaatggca ctcggcacca gaatctcact tcagttggca aaagcagcaa     7260

ttagcatgta atgaggcttc ttgctttatt tttaggtaac ctccaaggcc ctgcctgtgt     7320

aattcagccc gccattgctc ggtggataat taaagcatgt caccataa                  7368


<210>  15
<211>  912
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Pro Gly Lys Arg Gly Leu Gly Trp Trp Trp Ala Arg Leu Pro Leu 
1               5                   10                  15      


Cys Leu Leu Leu Ser Leu Tyr Gly Pro Trp Met Pro Ser Ser Leu Gly 
            20                  25                  30          


Lys Pro Lys Gly His Pro His Met Asn Ser Ile Arg Ile Asp Gly Asp 
        35                  40                  45              


Ile Thr Leu Gly Gly Leu Phe Pro Val His Gly Arg Gly Ser Glu Gly 
    50                  55                  60                  


Lys Pro Cys Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Phe Ala Leu Asp Arg Ile Asn Asn Asp Pro Asp Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr His Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu 
        115                 120                 125             


Lys Asp Gly Thr Glu Val Arg Cys Gly Ser Gly Gly Pro Pro Ile Ile 
    130                 135                 140                 


Thr Lys Pro Glu Arg Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Asp Leu Ser Asp Asn Ser Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Ser Asp Thr Tyr Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Arg Ala Leu Lys Trp Asn Tyr Val Ser Thr Val 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Ser Gly Val Glu Ala Phe Ile Gln 
225                 230                 235                 240 


Lys Ser Arg Glu Asp Gly Gly Val Cys Ile Ala Gln Ser Val Lys Ile 
                245                 250                 255     


Pro Arg Glu Pro Lys Ala Gly Glu Phe Asp Lys Ile Ile Arg Arg Leu 
            260                 265                 270         


Leu Glu Thr Ser Asn Ala Arg Ala Val Ile Ile Phe Ala Asn Glu Asp 
        275                 280                 285             


Asp Ile Arg Arg Val Leu Glu Ala Ala Arg Arg Ala Asn Gln Thr Gly 
    290                 295                 300                 


His Phe Phe Trp Met Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro 
305                 310                 315                 320 


Val Leu His Leu Glu Glu Val Ala Glu Gly Ala Val Thr Ile Leu Pro 
                325                 330                 335     


Lys Arg Met Ser Val Arg Gly Phe Asp Arg Tyr Phe Ser Ser Arg Thr 
            340                 345                 350         


Leu Asp Asn Asn Arg Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Asp 
        355                 360                 365             


Asn Phe His Cys Lys Leu Ser Arg His Ala Leu Lys Lys Gly Ser His 
    370                 375                 380                 


Val Lys Lys Cys Thr Asn Arg Glu Arg Ile Gly Gln Asp Ser Ala Tyr 
385                 390                 395                 400 


Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ala Met 
                405                 410                 415     


Gly His Ala Leu His Ala Met His Arg Asp Leu Cys Pro Gly Arg Val 
            420                 425                 430         


Gly Leu Cys Pro Arg Met Asp Pro Val Asp Gly Thr Gln Leu Leu Lys 
        435                 440                 445             


Tyr Ile Arg Asn Val Asn Phe Ser Gly Ile Ala Gly Asn Pro Val Thr 
    450                 455                 460                 


Phe Asn Glu Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Tyr Gln Tyr 
465                 470                 475                 480 


Gln Leu Arg Asn Asp Ser Ala Glu Tyr Lys Val Ile Gly Ser Trp Thr 
                485                 490                 495     


Asp His Leu His Leu Arg Ile Glu Arg Met His Trp Pro Gly Ser Gly 
            500                 505                 510         


Gln Gln Leu Pro Arg Ser Ile Cys Ser Leu Pro Cys Gln Pro Gly Glu 
        515                 520                 525             


Arg Lys Lys Thr Val Lys Gly Met Pro Cys Cys Trp His Cys Glu Pro 
    530                 535                 540                 


Cys Thr Gly Tyr Gln Tyr Gln Val Asp Arg Tyr Thr Cys Lys Thr Cys 
545                 550                 555                 560 


Pro Tyr Asp Met Arg Pro Thr Glu Asn Arg Thr Gly Cys Arg Pro Ile 
                565                 570                 575     


Pro Ile Ile Lys Leu Glu Trp Gly Ser Pro Trp Ala Val Leu Pro Leu 
            580                 585                 590         


Phe Leu Ala Val Val Gly Ile Ala Ala Thr Leu Phe Val Val Ile Thr 
        595                 600                 605             


Phe Val Arg Tyr Asn Asp Thr Pro Ile Val Lys Ala Ser Gly Arg Glu 
    610                 615                 620                 


Leu Ser Tyr Val Leu Leu Ala Gly Ile Phe Leu Cys Tyr Ala Thr Thr 
625                 630                 635                 640 


Phe Leu Met Ile Ala Glu Pro Asp Leu Gly Thr Cys Ser Leu Arg Arg 
                645                 650                 655     


Ile Phe Leu Gly Leu Gly Met Ser Ile Ser Tyr Ala Ala Leu Leu Thr 
            660                 665                 670         


Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val 
        675                 680                 685             


Ser Ala Pro Arg Phe Ile Ser Pro Ala Ser Gln Leu Ala Ile Thr Phe 
    690                 695                 700                 


Ser Leu Ile Ser Leu Gln Leu Leu Gly Ile Cys Val Trp Phe Val Val 
705                 710                 715                 720 


Asp Pro Ser His Ser Val Val Asp Phe Gln Asp Gln Arg Thr Leu Asp 
                725                 730                 735     


Pro Arg Phe Ala Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser 
            740                 745                 750         


Leu Ile Cys Leu Leu Gly Tyr Ser Met Leu Leu Met Val Thr Cys Thr 
        755                 760                 765             


Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala 
    770                 775                 780                 


Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val Trp Leu Ala 
785                 790                 795                 800 


Phe Ile Pro Ile Phe Phe Gly Thr Ser Gln Ser Ala Asp Lys Leu Tyr 
                805                 810                 815     


Ile Gln Thr Thr Thr Leu Thr Val Ser Val Ser Leu Ser Ala Ser Val 
            820                 825                 830         


Ser Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile Leu Phe His 
        835                 840                 845             


Pro Glu Gln Asn Val Pro Lys Arg Lys Arg Ser Leu Lys Ala Val Val 
    850                 855                 860                 


Thr Ala Ala Thr Met Ser Asn Lys Phe Thr Gln Lys Gly Asn Phe Arg 
865                 870                 875                 880 


Pro Asn Gly Glu Ala Lys Ser Glu Leu Cys Glu Asn Leu Glu Ala Pro 
                885                 890                 895     


Ala Leu Ala Thr Lys Gln Thr Tyr Val Thr Tyr Thr Asn His Ala Ile 
            900                 905                 910         


<210>  16

<400>  16
000

<210>  17
<211>  772
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Val Gln Thr Leu Pro Lys Leu Phe Pro His Asp Gly Ala Lys Arg 
1               5                   10                  15      


Lys Lys Arg Thr Leu Arg Thr Ser Gly Pro Cys Phe Gly Gly Gly Gly 
            20                  25                  30          


Gln Ile Pro Gln Ile Ser Tyr Ala Ser Thr Ala Pro Asp Leu Ser Asp 
        35                  40                  45              


Asn Ser Arg Tyr Asp Phe Phe Ser Arg Val Val Pro Ser Asp Thr Tyr 
    50                  55                  60                  


Gln Ala Gln Ala Met Val Asp Ile Val Arg Ala Leu Lys Trp Asn Tyr 
65                  70                  75                  80  


Val Ser Thr Val Ala Ser Glu Gly Ser Tyr Gly Glu Ser Gly Val Glu 
                85                  90                  95      


Ala Phe Ile Gln Lys Ser Arg Glu Asp Gly Gly Val Cys Ile Ala Gln 
            100                 105                 110         


Ser Val Lys Ile Pro Arg Glu Pro Lys Ala Gly Glu Phe Asp Lys Ile 
        115                 120                 125             


Ile Arg Arg Leu Leu Glu Thr Ser Asn Ala Arg Ala Val Ile Ile Phe 
    130                 135                 140                 


Ala Asn Glu Asp Asp Ile Arg Arg Val Leu Glu Ala Ala Arg Arg Ala 
145                 150                 155                 160 


Asn Gln Thr Gly His Phe Phe Trp Met Gly Ser Asp Ser Trp Gly Ser 
                165                 170                 175     


Lys Ile Ala Pro Val Leu His Leu Glu Glu Val Ala Glu Gly Ala Val 
            180                 185                 190         


Thr Ile Leu Pro Lys Arg Met Ser Val Arg Gly Phe Asp Arg Tyr Phe 
        195                 200                 205             


Ser Ser Arg Thr Leu Asp Asn Asn Arg Arg Asn Ile Trp Phe Ala Glu 
    210                 215                 220                 


Phe Trp Glu Asp Asn Phe His Cys Lys Leu Ser Arg His Ala Leu Lys 
225                 230                 235                 240 


Lys Gly Ser His Val Lys Lys Cys Thr Asn Arg Glu Arg Ile Gly Gln 
                245                 250                 255     


Asp Ser Ala Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala 
            260                 265                 270         


Val Tyr Ala Met Gly His Ala Leu His Ala Met His Arg Asp Leu Cys 
        275                 280                 285             


Pro Gly Arg Val Gly Leu Cys Pro Arg Met Asp Pro Val Asp Gly Thr 
    290                 295                 300                 


Gln Leu Leu Lys Tyr Ile Arg Asn Val Asn Phe Ser Gly Ile Ala Gly 
305                 310                 315                 320 


Asn Pro Val Thr Phe Asn Glu Asn Gly Asp Ala Pro Gly Arg Tyr Asp 
                325                 330                 335     


Ile Tyr Gln Tyr Gln Leu Arg Asn Asp Ser Ala Glu Tyr Lys Val Ile 
            340                 345                 350         


Gly Ser Trp Thr Asp His Leu His Leu Arg Ile Glu Arg Met His Trp 
        355                 360                 365             


Pro Gly Ser Gly Gln Gln Leu Pro Arg Ser Ile Cys Ser Leu Pro Cys 
    370                 375                 380                 


Gln Pro Gly Glu Arg Lys Lys Thr Val Lys Gly Met Pro Cys Cys Trp 
385                 390                 395                 400 


His Cys Glu Pro Cys Thr Gly Tyr Gln Tyr Gln Val Asp Arg Tyr Thr 
                405                 410                 415     


Cys Lys Thr Cys Pro Tyr Asp Met Arg Pro Thr Glu Asn Arg Thr Gly 
            420                 425                 430         


Cys Arg Pro Ile Pro Ile Ile Lys Leu Glu Trp Gly Ser Pro Trp Ala 
        435                 440                 445             


Val Leu Pro Leu Phe Leu Ala Val Val Gly Ile Ala Ala Thr Leu Phe 
    450                 455                 460                 


Val Val Ile Thr Phe Val Arg Tyr Asn Asp Thr Pro Ile Val Lys Ala 
465                 470                 475                 480 


Ser Gly Arg Glu Leu Ser Tyr Val Leu Leu Ala Gly Ile Phe Leu Cys 
                485                 490                 495     


Tyr Ala Thr Thr Phe Leu Met Ile Ala Glu Pro Asp Leu Gly Thr Cys 
            500                 505                 510         


Ser Leu Arg Arg Ile Phe Leu Gly Leu Gly Met Ser Ile Ser Tyr Ala 
        515                 520                 525             


Ala Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly 
    530                 535                 540                 


Lys Arg Ser Val Ser Ala Pro Arg Phe Ile Ser Pro Ala Ser Gln Leu 
545                 550                 555                 560 


Ala Ile Thr Phe Ser Leu Ile Ser Leu Gln Leu Leu Gly Ile Cys Val 
                565                 570                 575     


Trp Phe Val Val Asp Pro Ser His Ser Val Val Asp Phe Gln Asp Gln 
            580                 585                 590         


Arg Thr Leu Asp Pro Arg Phe Ala Arg Gly Val Leu Lys Cys Asp Ile 
        595                 600                 605             


Ser Asp Leu Ser Leu Ile Cys Leu Leu Gly Tyr Ser Met Leu Leu Met 
    610                 615                 620                 


Val Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Thr 
625                 630                 635                 640 


Phe Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile 
                645                 650                 655     


Val Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ser Gln Ser Ala 
            660                 665                 670         


Asp Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Val Ser Val Ser Leu 
        675                 680                 685             


Ser Ala Ser Val Ser Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile 
    690                 695                 700                 


Ile Leu Phe His Pro Glu Gln Asn Val Pro Lys Arg Lys Arg Ser Leu 
705                 710                 715                 720 


Lys Ala Val Val Thr Ala Ala Thr Met Ser Asn Lys Phe Thr Gln Lys 
                725                 730                 735     


Gly Asn Phe Arg Pro Asn Gly Glu Ala Lys Ser Glu Leu Cys Glu Asn 
            740                 745                 750         


Leu Glu Ala Pro Ala Leu Ala Thr Lys Gln Thr Tyr Val Thr Tyr Thr 
        755                 760                 765             


Asn His Ala Ile 
    770         


<210>  18
<211>  6518
<212>  DNA
<213>  Homo sapiens

<400>  18
gatgccctgg ggactcacgg gctgcaggtg ctaccagccc agcaccccgg cacagcgggg       60

aggctgaggc agacacacgc tcctggagag acatgtcatg taagataccc cagatcagct      120

acgcctccac agcgccagac ctgagtgaca acagccgcta cgacttcttc tcccgcgtgg      180

tgccctcgga cacgtaccag gcccaggcca tggtggacat cgtccgtgcc ctcaagtgga      240

actatgtgtc cacagtggcc tcggagggca gctatggtga gagcggtgtg gaggccttca      300

tccagaagtc ccgtgaggac gggggcgtgt gcatcgccca gtcggtgaag ataccacggg      360

agcccaaggc aggcgagttc gacaagatca tccgccgcct cctggagact tcgaacgcca      420

gggcagtcat catctttgcc aacgaggatg acatcaggcg tgtgctggag gcagcacgaa      480

gggccaacca gacaggccat ttcttctgga tgggctctga cagctggggc tccaagattg      540

cacctgtgct gcacctggag gaggtggctg agggtgctgt cacgatcctc cccaagagga      600

tgtccgtacg aggcttcgac cgctacttct ccagccgcac gctggacaac aaccggcgca      660

acatctggtt tgccgagttc tgggaggaca acttccactg caagctgagc cgccacgccc      720

tcaagaaggg cagccacgtc aagaagtgca ccaaccgtga gcgaattggg caggattcag      780

cttatgagca ggaggggaag gtgcagtttg tgatcgatgc cgtgtacgcc atgggccacg      840

cgctgcacgc catgcaccgt gacctgtgtc ccggccgcgt ggggctctgc ccgcgcatgg      900

accctgtaga tggcacccag ctgcttaagt acatccgaaa cgtcaacttc tcaggcatcg      960

cagggaaccc tgtgaccttc aatgagaatg gagatgcgcc tgggcgctat gacatctacc     1020

aataccagct gcgcaacgat tctgccgagt acaaggtcat tggctcctgg actgaccacc     1080

tgcaccttag aatagagcgg atgcactggc cggggagcgg gcagcagctg ccccgctcca     1140

tctgcagcct gccctgccaa ccgggtgagc ggaagaagac agtgaagggc atgccttgct     1200

gctggcactg cgagccttgc acagggtacc agtaccaggt ggaccgctac acctgtaaga     1260

cgtgtcccta tgacatgcgg cccacagaga accgcacggg ctgccggccc atccccatca     1320

tcaagcttga gtggggctcg ccctgggccg tgctgcccct cttcctggcc gtggtgggca     1380

tcgctgccac gttgttcgtg gtgatcacct ttgtgcgcta caacgacacg cccatcgtca     1440

aggcctcggg ccgtgaactg agctacgtgc tgctggcagg catcttcctg tgctatgcca     1500

ccaccttcct catgatcgct gagcccgacc ttggcacctg ctcgctgcgc cgaatcttcc     1560

tgggactagg gatgagcatc agctatgcag ccctgctcac caagaccaac cgcatctacc     1620

gcatcttcga gcagggcaag cgctcggtca gtgccccacg cttcatcagc cccgcctcac     1680

agctggccat caccttcagc ctcatctcgc tgcagctgct gggcatctgt gtgtggtttg     1740

tggtggaccc ctcccactcg gtggtggact tccaggacca gcggacactc gacccccgct     1800

tcgccagggg tgtgctcaag tgtgacatct cggacctgtc gctcatctgc ctgctgggct     1860

acagcatgct gctcatggtc acgtgcaccg tgtatgccat caagacacgc ggcgtgcccg     1920

agaccttcaa tgaggccaag cccattggct tcaccatgta caccacttgc atcgtctggc     1980

tggccttcat ccccatcttc tttggcacct cgcagtcggc cgacaagctg tacatccaga     2040

cgacgacgct gacggtctcg gtgagtctga gcgcctcggt gtccctggga atgctctaca     2100

tgcccaaagt ctacatcatc ctcttccacc cggagcagaa cgtgcccaag cgcaagcgca     2160

gcctcaaagc cgtcgttacg gcggccacca tgtccaacaa gttcacgcag aagggcaact     2220

tccggcccaa cggagaggcc aagtctgagc tctgcgagaa ccttgaggcc ccagcgctgg     2280

ccaccaaaca gacttacgtc acttacacca accatgcaat ctagcgagtc catggagctg     2340

agcagcagga ggaggagccg tgaccctgtg gaaggtgcgt cgggccaggg ccacacccaa     2400

gggcccagct gtcttgcctg cccgtgggca cccacggacg tggcttggtg ctgaggatag     2460

cagagccccc agccatcact gctggcagcc tgggcaaacc gggtgagcaa caggaggacg     2520

aggggccggg gcggtgccag gctaccacaa gaacctgcgt cttggaccat tgcccctccc     2580

ggccccaaac cacaggggct caggtcgtgt gggccccagt gctagatctc tccctccctt     2640

cgtctctgtc tgtgctgttg gcgacccctc tgtctgtctc cagccctgtc tttctgttct     2700

cttatctctt tgtttcacct tttccctctc tggcgtcccc ggctgcttgt actcttggcc     2760

ttttctgtgt ctcctttctg gctcttgcct ccgcctctct ctctcatcct ctttgtcctc     2820

agctcctcct gctttcttgg gtcccaccag tgtcactttt ctgccgtttt ctttcctgtt     2880

ctcctctgct tcattctcgt ccagccattg ctcccctctc cctgccaccc ttccccagtt     2940

caccaaacct tacatgttgc aaaagagaaa aaaggaaaaa aaatcaaaac acaaaaaagc     3000

caaaacgaaa acaaatctcg agtgtgttgc caagtgctgc gtcctcctgg tggcctctgt     3060

gtgtgtccct gtggcccgca gcctgcccgc ctgccccgcc catctgccgt gtgtcttgcc     3120

cgcctgcccc gcccgtctgc cgtctgtctt gcccgcctgc ccgcctgccc ctcctgccga     3180

ccacacggag ttcagtgcct gggtgtttgg tgatggttat tgacgacaat gtgtagcgca     3240

tgattgtttt tataccaaga acatttctaa taaaaataaa cacatggttt tgcacccggg     3300

ctccacatcc actgagggtc ctgccatggg accacaggct cagcctgcag ctggagggct     3360

tagacctaga gggaagcggg aactgggctc tggagaccca gggcttgggg gctgtggaga     3420

ctgctcccta ggctgggatc tagtgtggtg tggtgaggcc ttgggcatgg aggggccaga     3480

ttcccaggta aggggcaggg acattgcagg aaattccagg aatcagcacc tagtagtccc     3540

ctaattaggg ggtatgctct gtcccctgcc ctgcagccct gggagggtaa catttctgcc     3600

ttgcctgtcc tctgtctcac acccctcaca cctgggactg cccttccacc cctgccccca     3660

taacctgtgc ctctctcctt ccagccagga agtcctcttc ttgagaagtt agcttcccgg     3720

gctgccagca ctcatagccg tcccctcctg cttgtgttgg ctccaggctc gggtgctaag     3780

aagatgtgtg tctgtcctgg agatcagtgt gttgttatgt gtccacgtgg gcccacaagt     3840

gcacggcaca ggcatggccg tgtggctgtg ttggctgtgt tggctgtgtg tctgtgtgca     3900

cgtccagcgc ctccatgcgc atgcgtgcct gtcttgtttg cgtgtctgat catctgtttg     3960

ggccccggtg gctcatgcag atgcctgtct caggcccatg gcgagtgttc acctcagctg     4020

gcttccctgg caggttggga ggtgggaaac aggagcgctt aggggctggg ctctggctgg     4080

ggtaaattat agagccagaa acacaatgag gccataggca gcagctggag cctgggctgc     4140

ctgtgccgtc ccctcctgcc ctgcccctgg gtcctgcacc ccctcccacc tccaggctag     4200

ctgacagcgc tatggagcac agtggaaggg actggaggaa ccctaggcag ggggccacgc     4260

agggacagag tatgagagtg tgtgtataac tgaggctggg acattgaatc atgccaggta     4320

tgtcttctcc atcagcccac tcttactcct ggcctgggca tctcacacat ctgtgcatag     4380

gaaatctctt cttccctggg gtctgtgtgc agcacctagt agatgctcaa taaatgtttg     4440

tgtgagggaa ggagacagga aaggaagtgt ctcgctgatc atcttgcgga atggttccta     4500

agacctctgc ccaggaaaga ttccacccag tgctccagcc cggtcaggca gaactaggtt     4560

gccagatcaa gggtatctcc caaaagcttc cagggcagtt gggggtgggg gggtgggggg     4620

tagggatggg gaatgcagaa gcgggtgcag ccagctctcc cccagggtga ctctggcagc     4680

acccccatcc tgggcaccct gcctgctctg tggctcacgc ccctcctgaa gtgactgatg     4740

ctctgaggcc caaggctagg tccagggcag ggcctgcagg ggtttcatgc tcagtccagg     4800

acttgcctag gtccccctac atctgtgggg cccccatcta ggttctaaca ggagaatcac     4860

ctctccaagg gggatgctgc ccctcggctc cccttggctc tcaggagggg ccctcaggga     4920

ctaccagtcc cctgccagtg ggaagaaata gccctgccct cagggagctt ccagtgtgat     4980

gggggagata cagcagactg tgtcccaaag taaaatgact gttagaatga ggtgggtgga     5040

ggagggaagc cttgggtggg tgtgactttg ggcatctgag cctggggtgc agaggtgggc     5100

tctgtgggcc tgaggtggac aggagggaac caggccctag caagactttt gccagctaga     5160

cctgctgcag cagttgggag ggtgggtgct gctggagtcc tgggtccatc acctagaagg     5220

ctcaggccag tgcagccagg gctggggccc acagctggcc tgggtgggac ctgccctgat     5280

gcccatggca ggagggacgc ctggcccttc acaattggct tggctgctca cctttgctct     5340

catcctcaat tattaatgac tggagaaagc tgctaagtat cttcagaatg ttagatttca     5400

acaagatggg gggttcaggg tccctggcac cctggatagg gagccagcgg cccctagaga     5460

cctttgctgt gtgcaggggg tatgtgctca cccccgtggc ctcagcctcc tcaatgtctg     5520

aatgaaggat tgggctagca gacatcccac cccacagcac actttctaac cagcagggga     5580

acttctagac aatagagacg ctgggctccc tccagaacac tggacctgaa cttctggggg     5640

gagggctggg cacgggcata ttttaaaagc tccccagcag atgggccgtg cagtcaagtg     5700

ggccaagagt ggcaccagac tttggggctt gtgaagtcag gagggagcaa cagtgcccac     5760

tcgagcttgc ctggggctca agcccaaggc tgggctgctg ccagcctgag cagacaccca     5820

ggagcttcca ggccagctgg atgcacaggg cacctttgtg gaactcctag gaccctgggg     5880

agacccacct caggagcaga gtctcaggtc ccttccggct ctgaggggct gttctgagct     5940

ctaatgtctt atggtctgcc cctcccatcc ttacttctca ggccctggag gcagaggcat     6000

agagccaggc aggacagagg tctcagtggg ccacatgcca gctgccccca cactgcctca     6060

gcctccaggc ctccaagggg tcctggggag cccctgagaa gatgctgagc ctgcataagg     6120

ctgggcgccc ctctttctga caccctcact ggctccacgg ctcccccttc ccatcccagg     6180

tttccatctg cccactgaac agggagggga aactgaggca ctcccctggc actgagggct     6240

ccttctgtca tcctgcctgc cctggatggt cctggctgcc cctcagggct tggccctggc     6300

actgtgagcc tcacagggct cagaccccca cccccaaccc agcactaaat ggcactcggc     6360

accagaatct cacttcagtt ggcaaaagca gcaattagca tgtaatgagg cttcttgctt     6420

tatttttagg taacctccaa ggccctgcct gtgtaattca gcccgccatt gctcggtgga     6480

taattaaagc atgtcaccat aaaaaaaaaa aaaaaaaa                             6518


<210>  19
<211>  743
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ser Cys Lys Ile Pro Gln Ile Ser Tyr Ala Ser Thr Ala Pro Asp 
1               5                   10                  15      


Leu Ser Asp Asn Ser Arg Tyr Asp Phe Phe Ser Arg Val Val Pro Ser 
            20                  25                  30          


Asp Thr Tyr Gln Ala Gln Ala Met Val Asp Ile Val Arg Ala Leu Lys 
        35                  40                  45              


Trp Asn Tyr Val Ser Thr Val Ala Ser Glu Gly Ser Tyr Gly Glu Ser 
    50                  55                  60                  


Gly Val Glu Ala Phe Ile Gln Lys Ser Arg Glu Asp Gly Gly Val Cys 
65                  70                  75                  80  


Ile Ala Gln Ser Val Lys Ile Pro Arg Glu Pro Lys Ala Gly Glu Phe 
                85                  90                  95      


Asp Lys Ile Ile Arg Arg Leu Leu Glu Thr Ser Asn Ala Arg Ala Val 
            100                 105                 110         


Ile Ile Phe Ala Asn Glu Asp Asp Ile Arg Arg Val Leu Glu Ala Ala 
        115                 120                 125             


Arg Arg Ala Asn Gln Thr Gly His Phe Phe Trp Met Gly Ser Asp Ser 
    130                 135                 140                 


Trp Gly Ser Lys Ile Ala Pro Val Leu His Leu Glu Glu Val Ala Glu 
145                 150                 155                 160 


Gly Ala Val Thr Ile Leu Pro Lys Arg Met Ser Val Arg Gly Phe Asp 
                165                 170                 175     


Arg Tyr Phe Ser Ser Arg Thr Leu Asp Asn Asn Arg Arg Asn Ile Trp 
            180                 185                 190         


Phe Ala Glu Phe Trp Glu Asp Asn Phe His Cys Lys Leu Ser Arg His 
        195                 200                 205             


Ala Leu Lys Lys Gly Ser His Val Lys Lys Cys Thr Asn Arg Glu Arg 
    210                 215                 220                 


Ile Gly Gln Asp Ser Ala Tyr Glu Gln Glu Gly Lys Val Gln Phe Val 
225                 230                 235                 240 


Ile Asp Ala Val Tyr Ala Met Gly His Ala Leu His Ala Met His Arg 
                245                 250                 255     


Asp Leu Cys Pro Gly Arg Val Gly Leu Cys Pro Arg Met Asp Pro Val 
            260                 265                 270         


Asp Gly Thr Gln Leu Leu Lys Tyr Ile Arg Asn Val Asn Phe Ser Gly 
        275                 280                 285             


Ile Ala Gly Asn Pro Val Thr Phe Asn Glu Asn Gly Asp Ala Pro Gly 
    290                 295                 300                 


Arg Tyr Asp Ile Tyr Gln Tyr Gln Leu Arg Asn Asp Ser Ala Glu Tyr 
305                 310                 315                 320 


Lys Val Ile Gly Ser Trp Thr Asp His Leu His Leu Arg Ile Glu Arg 
                325                 330                 335     


Met His Trp Pro Gly Ser Gly Gln Gln Leu Pro Arg Ser Ile Cys Ser 
            340                 345                 350         


Leu Pro Cys Gln Pro Gly Glu Arg Lys Lys Thr Val Lys Gly Met Pro 
        355                 360                 365             


Cys Cys Trp His Cys Glu Pro Cys Thr Gly Tyr Gln Tyr Gln Val Asp 
    370                 375                 380                 


Arg Tyr Thr Cys Lys Thr Cys Pro Tyr Asp Met Arg Pro Thr Glu Asn 
385                 390                 395                 400 


Arg Thr Gly Cys Arg Pro Ile Pro Ile Ile Lys Leu Glu Trp Gly Ser 
                405                 410                 415     


Pro Trp Ala Val Leu Pro Leu Phe Leu Ala Val Val Gly Ile Ala Ala 
            420                 425                 430         


Thr Leu Phe Val Val Ile Thr Phe Val Arg Tyr Asn Asp Thr Pro Ile 
        435                 440                 445             


Val Lys Ala Ser Gly Arg Glu Leu Ser Tyr Val Leu Leu Ala Gly Ile 
    450                 455                 460                 


Phe Leu Cys Tyr Ala Thr Thr Phe Leu Met Ile Ala Glu Pro Asp Leu 
465                 470                 475                 480 


Gly Thr Cys Ser Leu Arg Arg Ile Phe Leu Gly Leu Gly Met Ser Ile 
                485                 490                 495     


Ser Tyr Ala Ala Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe 
            500                 505                 510         


Glu Gln Gly Lys Arg Ser Val Ser Ala Pro Arg Phe Ile Ser Pro Ala 
        515                 520                 525             


Ser Gln Leu Ala Ile Thr Phe Ser Leu Ile Ser Leu Gln Leu Leu Gly 
    530                 535                 540                 


Ile Cys Val Trp Phe Val Val Asp Pro Ser His Ser Val Val Asp Phe 
545                 550                 555                 560 


Gln Asp Gln Arg Thr Leu Asp Pro Arg Phe Ala Arg Gly Val Leu Lys 
                565                 570                 575     


Cys Asp Ile Ser Asp Leu Ser Leu Ile Cys Leu Leu Gly Tyr Ser Met 
            580                 585                 590         


Leu Leu Met Val Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val 
        595                 600                 605             


Pro Glu Thr Phe Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr 
    610                 615                 620                 


Thr Cys Ile Val Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ser 
625                 630                 635                 640 


Gln Ser Ala Asp Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Val Ser 
                645                 650                 655     


Val Ser Leu Ser Ala Ser Val Ser Leu Gly Met Leu Tyr Met Pro Lys 
            660                 665                 670         


Val Tyr Ile Ile Leu Phe His Pro Glu Gln Asn Val Pro Lys Arg Lys 
        675                 680                 685             


Arg Ser Leu Lys Ala Val Val Thr Ala Ala Thr Met Ser Asn Lys Phe 
    690                 695                 700                 


Thr Gln Lys Gly Asn Phe Arg Pro Asn Gly Glu Ala Lys Ser Glu Leu 
705                 710                 715                 720 


Cys Glu Asn Leu Glu Ala Pro Ala Leu Ala Thr Lys Gln Thr Tyr Val 
                725                 730                 735     


Thr Tyr Thr Asn His Ala Ile 
            740             


<210>  20
<211>  6711
<212>  DNA
<213>  Homo sapiens

<400>  20
agagatgctg gagctgtgga cctgggcggt cctggtggag gagtgcctga cacatcccag       60

tctttcaccg tggtgcctgt ggacagatga ggagactgag gctcacaaag gaggtgactt      120

gcccaaggtc acacagcgag gcagcttctc acctatggga gttggacttt gagccctcct      180

tggaaaaggg ggcatggctg tgccccttgg ggctccttgc tgggcctctg ccctgcctgc      240

ctgggctcct cccggcctcc cccacagatc actgttgaca aggttactga gtcagcatgt      300

aaaacctgca aaaatacccc agatcagcta cgcctccaca gcgccagacc tgagtgacaa      360

cagccgctac gacttcttct cccgcgtggt gccctcggac acgtaccagg cccaggccat      420

ggtggacatc gtccgtgccc tcaagtggaa ctatgtgtcc acagtggcct cggagggcag      480

ctatggtgag agcggtgtgg aggccttcat ccagaagtcc cgtgaggacg ggggcgtgtg      540

catcgcccag tcggtgaaga taccacggga gcccaaggca ggcgagttcg acaagatcat      600

ccgccgcctc ctggagactt cgaacgccag ggcagtcatc atctttgcca acgaggatga      660

catcaggcgt gtgctggagg cagcacgaag ggccaaccag acaggccatt tcttctggat      720

gggctctgac agctggggct ccaagattgc acctgtgctg cacctggagg aggtggctga      780

gggtgctgtc acgatcctcc ccaagaggat gtccgtacga ggcttcgacc gctacttctc      840

cagccgcacg ctggacaaca accggcgcaa catctggttt gccgagttct gggaggacaa      900

cttccactgc aagctgagcc gccacgccct caagaagggc agccacgtca agaagtgcac      960

caaccgtgag cgaattgggc aggattcagc ttatgagcag gaggggaagg tgcagtttgt     1020

gatcgatgcc gtgtacgcca tgggccacgc gctgcacgcc atgcaccgtg acctgtgtcc     1080

cggccgcgtg gggctctgcc cgcgcatgga ccctgtagat ggcacccagc tgcttaagta     1140

catccgaaac gtcaacttct caggcatcgc agggaaccct gtgaccttca atgagaatgg     1200

agatgcgcct gggcgctatg acatctacca ataccagctg cgcaacgatt ctgccgagta     1260

caaggtcatt ggctcctgga ctgaccacct gcaccttaga atagagcgga tgcactggcc     1320

ggggagcggg cagcagctgc cccgctccat ctgcagcctg ccctgccaac cgggtgagcg     1380

gaagaagaca gtgaagggca tgccttgctg ctggcactgc gagccttgca cagggtacca     1440

gtaccaggtg gaccgctaca cctgtaagac gtgtccctat gacatgcggc ccacagagaa     1500

ccgcacgggc tgccggccca tccccatcat caagcttgag tggggctcgc cctgggccgt     1560

gctgcccctc ttcctggccg tggtgggcat cgctgccacg ttgttcgtgg tgatcacctt     1620

tgtgcgctac aacgacacgc ccatcgtcaa ggcctcgggc cgtgaactga gctacgtgct     1680

gctggcaggc atcttcctgt gctatgccac caccttcctc atgatcgctg agcccgacct     1740

tggcacctgc tcgctgcgcc gaatcttcct gggactaggg atgagcatca gctatgcagc     1800

cctgctcacc aagaccaacc gcatctaccg catcttcgag cagggcaagc gctcggtcag     1860

tgccccacgc ttcatcagcc ccgcctcaca gctggccatc accttcagcc tcatctcgct     1920

gcagctgctg ggcatctgtg tgtggtttgt ggtggacccc tcccactcgg tggtggactt     1980

ccaggaccag cggacactcg acccccgctt cgccaggggt gtgctcaagt gtgacatctc     2040

ggacctgtcg ctcatctgcc tgctgggcta cagcatgctg ctcatggtca cgtgcaccgt     2100

gtatgccatc aagacacgcg gcgtgcccga gaccttcaat gaggccaagc ccattggctt     2160

caccatgtac accacttgca tcgtctggct ggccttcatc cccatcttct ttggcacctc     2220

gcagtcggcc gacaagctgt acatccagac gacgacgctg acggtctcgg tgagtctgag     2280

cgcctcggtg tccctgggaa tgctctacat gcccaaagtc tacatcatcc tcttccaccc     2340

ggagcagaac gtgcccaagc gcaagcgcag cctcaaagcc gtcgttacgg cggccaccat     2400

gtccaacaag ttcacgcaga agggcaactt ccggcccaac ggagaggcca agtctgagct     2460

ctgcgagaac cttgaggccc cagcgctggc caccaaacag acttacgtca cttacaccaa     2520

ccatgcaatc tagcgagtcc atggagctga gcagcaggag gaggagccgt gaccctgtgg     2580

aaggtgcgtc gggccagggc cacacccaag ggcccagctg tcttgcctgc ccgtgggcac     2640

ccacggacgt ggcttggtgc tgaggatagc agagccccca gccatcactg ctggcagcct     2700

gggcaaaccg ggtgagcaac aggaggacga ggggccgggg cggtgccagg ctaccacaag     2760

aacctgcgtc ttggaccatt gcccctcccg gccccaaacc acaggggctc aggtcgtgtg     2820

ggccccagtg ctagatctct ccctcccttc gtctctgtct gtgctgttgg cgacccctct     2880

gtctgtctcc agccctgtct ttctgttctc ttatctcttt gtttcacctt ttccctctct     2940

ggcgtccccg gctgcttgta ctcttggcct tttctgtgtc tcctttctgg ctcttgcctc     3000

cgcctctctc tctcatcctc tttgtcctca gctcctcctg ctttcttggg tcccaccagt     3060

gtcacttttc tgccgttttc tttcctgttc tcctctgctt cattctcgtc cagccattgc     3120

tcccctctcc ctgccaccct tccccagttc accaaacctt acatgttgca aaagagaaaa     3180

aaggaaaaaa aatcaaaaca caaaaaagcc aaaacgaaaa caaatctcga gtgtgttgcc     3240

aagtgctgcg tcctcctggt ggcctctgtg tgtgtccctg tggcccgcag cctgcccgcc     3300

tgccccgccc atctgccgtg tgtcttgccc gcctgccccg cccgtctgcc gtctgtcttg     3360

cccgcctgcc cgcctgcccc tcctgccgac cacacggagt tcagtgcctg ggtgtttggt     3420

gatggttatt gacgacaatg tgtagcgcat gattgttttt ataccaagaa catttctaat     3480

aaaaataaac acatggtttt gcacccgggc tccacatcca ctgagggtcc tgccatggga     3540

ccacaggctc agcctgcagc tggagggctt agacctagag ggaagcggga actgggctct     3600

ggagacccag ggcttggggg ctgtggagac tgctccctag gctgggatct agtgtggtgt     3660

ggtgaggcct tgggcatgga ggggccagat tcccaggtaa ggggcaggga cattgcagga     3720

aattccagga atcagcacct agtagtcccc taattagggg gtatgctctg tcccctgccc     3780

tgcagccctg ggagggtaac atttctgcct tgcctgtcct ctgtctcaca cccctcacac     3840

ctgggactgc ccttccaccc ctgcccccat aacctgtgcc tctctccttc cagccaggaa     3900

gtcctcttct tgagaagtta gcttcccggg ctgccagcac tcatagccgt cccctcctgc     3960

ttgtgttggc tccaggctcg ggtgctaaga agatgtgtgt ctgtcctgga gatcagtgtg     4020

ttgttatgtg tccacgtggg cccacaagtg cacggcacag gcatggccgt gtggctgtgt     4080

tggctgtgtt ggctgtgtgt ctgtgtgcac gtccagcgcc tccatgcgca tgcgtgcctg     4140

tcttgtttgc gtgtctgatc atctgtttgg gccccggtgg ctcatgcaga tgcctgtctc     4200

aggcccatgg cgagtgttca cctcagctgg cttccctggc aggttgggag gtgggaaaca     4260

ggagcgctta ggggctgggc tctggctggg gtaaattata gagccagaaa cacaatgagg     4320

ccataggcag cagctggagc ctgggctgcc tgtgccgtcc cctcctgccc tgcccctggg     4380

tcctgcaccc cctcccacct ccaggctagc tgacagcgct atggagcaca gtggaaggga     4440

ctggaggaac cctaggcagg gggccacgca gggacagagt atgagagtgt gtgtataact     4500

gaggctggga cattgaatca tgccaggtat gtcttctcca tcagcccact cttactcctg     4560

gcctgggcat ctcacacatc tgtgcatagg aaatctcttc ttccctgggg tctgtgtgca     4620

gcacctagta gatgctcaat aaatgtttgt gtgagggaag gagacaggaa aggaagtgtc     4680

tcgctgatca tcttgcggaa tggttcctaa gacctctgcc caggaaagat tccacccagt     4740

gctccagccc ggtcaggcag aactaggttg ccagatcaag ggtatctccc aaaagcttcc     4800

agggcagttg ggggtggggg ggtggggggt agggatgggg aatgcagaag cgggtgcagc     4860

cagctctccc ccagggtgac tctggcagca cccccatcct gggcaccctg cctgctctgt     4920

ggctcacgcc cctcctgaag tgactgatgc tctgaggccc aaggctaggt ccagggcagg     4980

gcctgcaggg gtttcatgct cagtccagga cttgcctagg tccccctaca tctgtggggc     5040

ccccatctag gttctaacag gagaatcacc tctccaaggg ggatgctgcc cctcggctcc     5100

ccttggctct caggaggggc cctcagggac taccagtccc ctgccagtgg gaagaaatag     5160

ccctgccctc agggagcttc cagtgtgatg ggggagatac agcagactgt gtcccaaagt     5220

aaaatgactg ttagaatgag gtgggtggag gagggaagcc ttgggtgggt gtgactttgg     5280

gcatctgagc ctggggtgca gaggtgggct ctgtgggcct gaggtggaca ggagggaacc     5340

aggccctagc aagacttttg ccagctagac ctgctgcagc agttgggagg gtgggtgctg     5400

ctggagtcct gggtccatca cctagaaggc tcaggccagt gcagccaggg ctggggccca     5460

cagctggcct gggtgggacc tgccctgatg cccatggcag gagggacgcc tggcccttca     5520

caattggctt ggctgctcac ctttgctctc atcctcaatt attaatgact ggagaaagct     5580

gctaagtatc ttcagaatgt tagatttcaa caagatgggg ggttcagggt ccctggcacc     5640

ctggataggg agccagcggc ccctagagac ctttgctgtg tgcagggggt atgtgctcac     5700

ccccgtggcc tcagcctcct caatgtctga atgaaggatt gggctagcag acatcccacc     5760

ccacagcaca ctttctaacc agcaggggaa cttctagaca atagagacgc tgggctccct     5820

ccagaacact ggacctgaac ttctgggggg agggctgggc acgggcatat tttaaaagct     5880

ccccagcaga tgggccgtgc agtcaagtgg gccaagagtg gcaccagact ttggggcttg     5940

tgaagtcagg agggagcaac agtgcccact cgagcttgcc tggggctcaa gcccaaggct     6000

gggctgctgc cagcctgagc agacacccag gagcttccag gccagctgga tgcacagggc     6060

acctttgtgg aactcctagg accctgggga gacccacctc aggagcagag tctcaggtcc     6120

cttccggctc tgaggggctg ttctgagctc taatgtctta tggtctgccc ctcccatcct     6180

tacttctcag gccctggagg cagaggcata gagccaggca ggacagaggt ctcagtgggc     6240

cacatgccag ctgcccccac actgcctcag cctccaggcc tccaaggggt cctggggagc     6300

ccctgagaag atgctgagcc tgcataaggc tgggcgcccc tctttctgac accctcactg     6360

gctccacggc tcccccttcc catcccaggt ttccatctgc ccactgaaca gggaggggaa     6420

actgaggcac tcccctggca ctgagggctc cttctgtcat cctgcctgcc ctggatggtc     6480

ctggctgccc ctcagggctt ggccctggca ctgtgagcct cacagggctc agacccccac     6540

ccccaaccca gcactaaatg gcactcggca ccagaatctc acttcagttg gcaaaagcag     6600

caattagcat gtaatgaggc ttcttgcttt atttttaggt aacctccaag gccctgcctg     6660

tgtaattcag cccgccattg ctcggtggat aattaaagca tgtcaccata a              6711


<210>  21
<211>  779
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Val Pro Leu Gly Ala Pro Cys Trp Ala Ser Ala Leu Pro Ala 
1               5                   10                  15      


Trp Ala Pro Pro Gly Leu Pro His Arg Ser Leu Leu Thr Arg Leu Leu 
            20                  25                  30          


Ser Gln His Val Lys Pro Ala Lys Ile Pro Gln Ile Ser Tyr Ala Ser 
        35                  40                  45              


Thr Ala Pro Asp Leu Ser Asp Asn Ser Arg Tyr Asp Phe Phe Ser Arg 
    50                  55                  60                  


Val Val Pro Ser Asp Thr Tyr Gln Ala Gln Ala Met Val Asp Ile Val 
65                  70                  75                  80  


Arg Ala Leu Lys Trp Asn Tyr Val Ser Thr Val Ala Ser Glu Gly Ser 
                85                  90                  95      


Tyr Gly Glu Ser Gly Val Glu Ala Phe Ile Gln Lys Ser Arg Glu Asp 
            100                 105                 110         


Gly Gly Val Cys Ile Ala Gln Ser Val Lys Ile Pro Arg Glu Pro Lys 
        115                 120                 125             


Ala Gly Glu Phe Asp Lys Ile Ile Arg Arg Leu Leu Glu Thr Ser Asn 
    130                 135                 140                 


Ala Arg Ala Val Ile Ile Phe Ala Asn Glu Asp Asp Ile Arg Arg Val 
145                 150                 155                 160 


Leu Glu Ala Ala Arg Arg Ala Asn Gln Thr Gly His Phe Phe Trp Met 
                165                 170                 175     


Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro Val Leu His Leu Glu 
            180                 185                 190         


Glu Val Ala Glu Gly Ala Val Thr Ile Leu Pro Lys Arg Met Ser Val 
        195                 200                 205             


Arg Gly Phe Asp Arg Tyr Phe Ser Ser Arg Thr Leu Asp Asn Asn Arg 
    210                 215                 220                 


Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Asp Asn Phe His Cys Lys 
225                 230                 235                 240 


Leu Ser Arg His Ala Leu Lys Lys Gly Ser His Val Lys Lys Cys Thr 
                245                 250                 255     


Asn Arg Glu Arg Ile Gly Gln Asp Ser Ala Tyr Glu Gln Glu Gly Lys 
            260                 265                 270         


Val Gln Phe Val Ile Asp Ala Val Tyr Ala Met Gly His Ala Leu His 
        275                 280                 285             


Ala Met His Arg Asp Leu Cys Pro Gly Arg Val Gly Leu Cys Pro Arg 
    290                 295                 300                 


Met Asp Pro Val Asp Gly Thr Gln Leu Leu Lys Tyr Ile Arg Asn Val 
305                 310                 315                 320 


Asn Phe Ser Gly Ile Ala Gly Asn Pro Val Thr Phe Asn Glu Asn Gly 
                325                 330                 335     


Asp Ala Pro Gly Arg Tyr Asp Ile Tyr Gln Tyr Gln Leu Arg Asn Asp 
            340                 345                 350         


Ser Ala Glu Tyr Lys Val Ile Gly Ser Trp Thr Asp His Leu His Leu 
        355                 360                 365             


Arg Ile Glu Arg Met His Trp Pro Gly Ser Gly Gln Gln Leu Pro Arg 
    370                 375                 380                 


Ser Ile Cys Ser Leu Pro Cys Gln Pro Gly Glu Arg Lys Lys Thr Val 
385                 390                 395                 400 


Lys Gly Met Pro Cys Cys Trp His Cys Glu Pro Cys Thr Gly Tyr Gln 
                405                 410                 415     


Tyr Gln Val Asp Arg Tyr Thr Cys Lys Thr Cys Pro Tyr Asp Met Arg 
            420                 425                 430         


Pro Thr Glu Asn Arg Thr Gly Cys Arg Pro Ile Pro Ile Ile Lys Leu 
        435                 440                 445             


Glu Trp Gly Ser Pro Trp Ala Val Leu Pro Leu Phe Leu Ala Val Val 
    450                 455                 460                 


Gly Ile Ala Ala Thr Leu Phe Val Val Ile Thr Phe Val Arg Tyr Asn 
465                 470                 475                 480 


Asp Thr Pro Ile Val Lys Ala Ser Gly Arg Glu Leu Ser Tyr Val Leu 
                485                 490                 495     


Leu Ala Gly Ile Phe Leu Cys Tyr Ala Thr Thr Phe Leu Met Ile Ala 
            500                 505                 510         


Glu Pro Asp Leu Gly Thr Cys Ser Leu Arg Arg Ile Phe Leu Gly Leu 
        515                 520                 525             


Gly Met Ser Ile Ser Tyr Ala Ala Leu Leu Thr Lys Thr Asn Arg Ile 
    530                 535                 540                 


Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val Ser Ala Pro Arg Phe 
545                 550                 555                 560 


Ile Ser Pro Ala Ser Gln Leu Ala Ile Thr Phe Ser Leu Ile Ser Leu 
                565                 570                 575     


Gln Leu Leu Gly Ile Cys Val Trp Phe Val Val Asp Pro Ser His Ser 
            580                 585                 590         


Val Val Asp Phe Gln Asp Gln Arg Thr Leu Asp Pro Arg Phe Ala Arg 
        595                 600                 605             


Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser Leu Ile Cys Leu Leu 
    610                 615                 620                 


Gly Tyr Ser Met Leu Leu Met Val Thr Cys Thr Val Tyr Ala Ile Lys 
625                 630                 635                 640 


Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro Ile Gly Phe 
                645                 650                 655     


Thr Met Tyr Thr Thr Cys Ile Val Trp Leu Ala Phe Ile Pro Ile Phe 
            660                 665                 670         


Phe Gly Thr Ser Gln Ser Ala Asp Lys Leu Tyr Ile Gln Thr Thr Thr 
        675                 680                 685             


Leu Thr Val Ser Val Ser Leu Ser Ala Ser Val Ser Leu Gly Met Leu 
    690                 695                 700                 


Tyr Met Pro Lys Val Tyr Ile Ile Leu Phe His Pro Glu Gln Asn Val 
705                 710                 715                 720 


Pro Lys Arg Lys Arg Ser Leu Lys Ala Val Val Thr Ala Ala Thr Met 
                725                 730                 735     


Ser Asn Lys Phe Thr Gln Lys Gly Asn Phe Arg Pro Asn Gly Glu Ala 
            740                 745                 750         


Lys Ser Glu Leu Cys Glu Asn Leu Glu Ala Pro Ala Leu Ala Thr Lys 
        755                 760                 765             


Gln Thr Tyr Val Thr Tyr Thr Asn His Ala Ile 
    770                 775                 


<210>  22
<211>  6801
<212>  DNA
<213>  Homo sapiens

<400>  22
aatcccagcg ctttgctgga ggatcgcttg agcccaggaa ttcaagacca gcctgggcaa       60

catggcgaga ccctgtctgt cccaaaacaa aaaaacagat tttaattggt ttgggatgcg      120

gcctggacac agggaaattt taaagctctc taggtaactc caatgtgcgt cgaggttgcg      180

aaccgccggc ctgtcacaca gagggagctc aggagatgct gagagtggga ggatgccggc      240

ttgggagcct ggagttgcag cttcctgcgg ctggcgcgcc cctccttgct cccctctacg      300

cctctgcatc gcaccccacc cctgtacccc accttcctcc caccaaggaa acctcacctg      360

ccgcctcccg cccaggtcct ttggattttg ccggtgtgtg tgggtgcgca caagaggccc      420

ctccctgcca ggagagcagg tgagcctggc cgcgcacgaa tccgaggggg cggccgccca      480

gctgggaagc agccctgaaa tagacccccg ccgcccccgc tgcctccttc cggaatctgc      540

tcagataccc cagatcagct acgcctccac agcgccagac ctgagtgaca acagccgcta      600

cgacttcttc tcccgcgtgg tgccctcgga cacgtaccag gcccaggcca tggtggacat      660

cgtccgtgcc ctcaagtgga actatgtgtc cacagtggcc tcggagggca gctatggtga      720

gagcggtgtg gaggccttca tccagaagtc ccgtgaggac gggggcgtgt gcatcgccca      780

gtcggtgaag ataccacggg agcccaaggc aggcgagttc gacaagatca tccgccgcct      840

cctggagact tcgaacgcca gggcagtcat catctttgcc aacgaggatg acatcaggcg      900

tgtgctggag gcagcacgaa gggccaacca gacaggccat ttcttctgga tgggctctga      960

cagctggggc tccaagattg cacctgtgct gcacctggag gaggtggctg agggtgctgt     1020

cacgatcctc cccaagagga tgtccgtacg agaccgtgag cgaattgggc aggattcagc     1080

ttatgagcag gaggggaagg tgcagtttgt gatcgatgcc gtgtacgcca tgggccacgc     1140

gctgcacgcc atgcaccgtg acctgtgtcc cggccgcgtg gggctctgcc cgcgcatgga     1200

ccctgtagat ggcacccagc tgcttaagta catccgaaac gtcaacttct caggcatcgc     1260

agggaaccct gtgaccttca atgagaatgg agatgcgcct gggcgctatg acatctacca     1320

ataccagctg cgcaacgatt ctgccgagta caaggtcatt ggctcctgga ctgaccacct     1380

gcaccttaga atagagcgga tgcactggcc ggggagcggg cagcagctgc cccgctccat     1440

ctgcagcctg ccctgccaac cgggtgagcg gaagaagaca gtgaagggca tgccttgctg     1500

ctggcactgc gagccttgca cagggtacca gtaccaggtg gaccgctaca cctgtaagac     1560

gtgtccctat gacatgcggc ccacagagaa ccgcacgggc tgccggccca tccccatcat     1620

caagcttgag tggggctcgc cctgggccgt gctgcccctc ttcctggccg tggtgggcat     1680

cgctgccacg ttgttcgtgg tgatcacctt tgtgcgctac aacgacacgc ccatcgtcaa     1740

ggcctcgggc cgtgaactga gctacgtgct gctggcaggc atcttcctgt gctatgccac     1800

caccttcctc atgatcgctg agcccgacct tggcacctgc tcgctgcgcc gaatcttcct     1860

gggactaggg atgagcatca gctatgcagc cctgctcacc aagaccaacc gcatctaccg     1920

catcttcgag cagggcaagc gctcggtcag tgccccacgc ttcatcagcc ccgcctcaca     1980

gctggccatc accttcagcc tcatctcgct gcagctgctg ggcatctgtg tgtggtttgt     2040

ggtggacccc tcccactcgg tggtggactt ccaggaccag cggacactcg acccccgctt     2100

cgccaggggt gtgctcaagt gtgacatctc ggacctgtcg ctcatctgcc tgctgggcta     2160

cagcatgctg ctcatggtca cgtgcaccgt gtatgccatc aagacacgcg gcgtgcccga     2220

gaccttcaat gaggccaagc ccattggctt caccatgtac accacttgca tcgtctggct     2280

ggccttcatc cccatcttct ttggcacctc gcagtcggcc gacaagctgt acatccagac     2340

gacgacgctg acggtctcgg tgagtctgag cgcctcggtg tccctgggaa tgctctacat     2400

gcccaaagtc tacatcatcc tcttccaccc ggagcagaac gtgcccaagc gcaagcgcag     2460

cctcaaagcc gtcgttacgg cggccaccat gtccaacaag ttcacgcaga agggcaactt     2520

ccggcccaac ggagaggcca agtctgagct ctgcgagaac cttgaggccc cagcgctggc     2580

caccaaacag acttacgtca cttacaccaa ccatgcaatc tagcgagtcc atggagctga     2640

gcagcaggag gaggagccgt gaccctgtgg aaggtgcgtc gggccagggc cacacccaag     2700

ggcccagctg tcttgcctgc ccgtgggcac ccacggacgt ggcttggtgc tgaggatagc     2760

agagccccca gccatcactg ctggcagcct gggcaaaccg ggtgagcaac aggaggacga     2820

ggggccgggg cggtgccagg ctaccacaag aacctgcgtc ttggaccatt gcccctcccg     2880

gccccaaacc acaggggctc aggtcgtgtg ggccccagtg ctagatctct ccctcccttc     2940

gtctctgtct gtgctgttgg cgacccctct gtctgtctcc agccctgtct ttctgttctc     3000

ttatctcttt gtttcacctt ttccctctct ggcgtccccg gctgcttgta ctcttggcct     3060

tttctgtgtc tcctttctgg ctcttgcctc cgcctctctc tctcatcctc tttgtcctca     3120

gctcctcctg ctttcttggg tcccaccagt gtcacttttc tgccgttttc tttcctgttc     3180

tcctctgctt cattctcgtc cagccattgc tcccctctcc ctgccaccct tccccagttc     3240

accaaacctt acatgttgca aaagagaaaa aaggaaaaaa aatcaaaaca caaaaaagcc     3300

aaaacgaaaa caaatctcga gtgtgttgcc aagtgctgcg tcctcctggt ggcctctgtg     3360

tgtgtccctg tggcccgcag cctgcccgcc tgccccgccc atctgccgtg tgtcttgccc     3420

gcctgccccg cccgtctgcc gtctgtcttg cccgcctgcc cgcctgcccc tcctgccgac     3480

cacacggagt tcagtgcctg ggtgtttggt gatggttatt gacgacaatg tgtagcgcat     3540

gattgttttt ataccaagaa catttctaat aaaaataaac acatggtttt gcacccgggc     3600

tccacatcca ctgagggtcc tgccatggga ccacaggctc agcctgcagc tggagggctt     3660

agacctagag ggaagcggga actgggctct ggagacccag ggcttggggg ctgtggagac     3720

tgctccctag gctgggatct agtgtggtgt ggtgaggcct tgggcatgga ggggccagat     3780

tcccaggtaa ggggcaggga cattgcagga aattccagga atcagcacct agtagtcccc     3840

taattagggg gtatgctctg tcccctgccc tgcagccctg ggagggtaac atttctgcct     3900

tgcctgtcct ctgtctcaca cccctcacac ctgggactgc ccttccaccc ctgcccccat     3960

aacctgtgcc tctctccttc cagccaggaa gtcctcttct tgagaagtta gcttcccggg     4020

ctgccagcac tcatagccgt cccctcctgc ttgtgttggc tccaggctcg ggtgctaaga     4080

agatgtgtgt ctgtcctgga gatcagtgtg ttgttatgtg tccacgtggg cccacaagtg     4140

cacggcacag gcatggccgt gtggctgtgt tggctgtgtt ggctgtgtgt ctgtgtgcac     4200

gtccagcgcc tccatgcgca tgcgtgcctg tcttgtttgc gtgtctgatc atctgtttgg     4260

gccccggtgg ctcatgcaga tgcctgtctc aggcccatgg cgagtgttca cctcagctgg     4320

cttccctggc aggttgggag gtgggaaaca ggagcgctta ggggctgggc tctggctggg     4380

gtaaattata gagccagaaa cacaatgagg ccataggcag cagctggagc ctgggctgcc     4440

tgtgccgtcc cctcctgccc tgcccctggg tcctgcaccc cctcccacct ccaggctagc     4500

tgacagcgct atggagcaca gtggaaggga ctggaggaac cctaggcagg gggccacgca     4560

gggacagagt atgagagtgt gtgtataact gaggctggga cattgaatca tgccaggtat     4620

gtcttctcca tcagcccact cttactcctg gcctgggcat ctcacacatc tgtgcatagg     4680

aaatctcttc ttccctgggg tctgtgtgca gcacctagta gatgctcaat aaatgtttgt     4740

gtgagggaag gagacaggaa aggaagtgtc tcgctgatca tcttgcggaa tggttcctaa     4800

gacctctgcc caggaaagat tccacccagt gctccagccc ggtcaggcag aactaggttg     4860

ccagatcaag ggtatctccc aaaagcttcc agggcagttg ggggtggggg ggtggggggt     4920

agggatgggg aatgcagaag cgggtgcagc cagctctccc ccagggtgac tctggcagca     4980

cccccatcct gggcaccctg cctgctctgt ggctcacgcc cctcctgaag tgactgatgc     5040

tctgaggccc aaggctaggt ccagggcagg gcctgcaggg gtttcatgct cagtccagga     5100

cttgcctagg tccccctaca tctgtggggc ccccatctag gttctaacag gagaatcacc     5160

tctccaaggg ggatgctgcc cctcggctcc ccttggctct caggaggggc cctcagggac     5220

taccagtccc ctgccagtgg gaagaaatag ccctgccctc agggagcttc cagtgtgatg     5280

ggggagatac agcagactgt gtcccaaagt aaaatgactg ttagaatgag gtgggtggag     5340

gagggaagcc ttgggtgggt gtgactttgg gcatctgagc ctggggtgca gaggtgggct     5400

ctgtgggcct gaggtggaca ggagggaacc aggccctagc aagacttttg ccagctagac     5460

ctgctgcagc agttgggagg gtgggtgctg ctggagtcct gggtccatca cctagaaggc     5520

tcaggccagt gcagccaggg ctggggccca cagctggcct gggtgggacc tgccctgatg     5580

cccatggcag gagggacgcc tggcccttca caattggctt ggctgctcac ctttgctctc     5640

atcctcaatt attaatgact ggagaaagct gctaagtatc ttcagaatgt tagatttcaa     5700

caagatgggg ggttcagggt ccctggcacc ctggataggg agccagcggc ccctagagac     5760

ctttgctgtg tgcagggggt atgtgctcac ccccgtggcc tcagcctcct caatgtctga     5820

atgaaggatt gggctagcag acatcccacc ccacagcaca ctttctaacc agcaggggaa     5880

cttctagaca atagagacgc tgggctccct ccagaacact ggacctgaac ttctgggggg     5940

agggctgggc acgggcatat tttaaaagct ccccagcaga tgggccgtgc agtcaagtgg     6000

gccaagagtg gcaccagact ttggggcttg tgaagtcagg agggagcaac agtgcccact     6060

cgagcttgcc tggggctcaa gcccaaggct gggctgctgc cagcctgagc agacacccag     6120

gagcttccag gccagctgga tgcacagggc acctttgtgg aactcctagg accctgggga     6180

gacccacctc aggagcagag tctcaggtcc cttccggctc tgaggggctg ttctgagctc     6240

taatgtctta tggtctgccc ctcccatcct tacttctcag gccctggagg cagaggcata     6300

gagccaggca ggacagaggt ctcagtgggc cacatgccag ctgcccccac actgcctcag     6360

cctccaggcc tccaaggggt cctggggagc ccctgagaag atgctgagcc tgcataaggc     6420

tgggcgcccc tctttctgac accctcactg gctccacggc tcccccttcc catcccaggt     6480

ttccatctgc ccactgaaca gggaggggaa actgaggcac tcccctggca ctgagggctc     6540

cttctgtcat cctgcctgcc ctggatggtc ctggctgccc ctcagggctt ggccctggca     6600

ctgtgagcct cacagggctc agacccccac ccccaaccca gcactaaatg gcactcggca     6660

ccagaatctc acttcagttg gcaaaagcag caattagcat gtaatgaggc ttcttgcttt     6720

atttttaggt aacctccaag gccctgcctg tgtaattcag cccgccattg ctcggtggat     6780

aattaaagca tgtcaccata a                                               6801


<210>  23
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Pro Ala Trp Glu Pro Gly Val Ala Ala Ser Cys Gly Trp Arg Ala 
1               5                   10                  15      


Pro Pro Cys Ser Pro Leu Arg Leu Cys Ile Ala Pro His Pro Cys Thr 
            20                  25                  30          


Pro Pro Ser Ser His Gln Gly Asn Leu Thr Cys Arg Leu Pro Pro Arg 
        35                  40                  45              


Ser Phe Gly Phe Cys Arg Cys Val Trp Val Arg Thr Arg Gly Pro Ser 
    50                  55                  60                  


Leu Pro Gly Glu Gln Val Ser Leu Ala Ala His Glu Ser Glu Gly Ala 
65                  70                  75                  80  


Ala Ala Gln Leu Gly Ser Ser Pro Glu Ile Asp Pro Arg Arg Pro Arg 
                85                  90                  95      


Cys Leu Leu Pro Glu Ser Ala Gln Ile Pro Gln Ile Ser Tyr Ala Ser 
            100                 105                 110         


Thr Ala Pro Asp Leu Ser Asp Asn Ser Arg Tyr Asp Phe Phe Ser Arg 
        115                 120                 125             


Val Val Pro Ser Asp Thr Tyr Gln Ala Gln Ala Met Val Asp Ile Val 
    130                 135                 140                 


Arg Ala Leu Lys Trp Asn Tyr Val Ser Thr Val Ala Ser Glu Gly Ser 
145                 150                 155                 160 


Tyr Gly Glu Ser Gly Val Glu Ala Phe Ile Gln Lys Ser Arg Glu Asp 
                165                 170                 175     


Gly Gly Val Cys Ile Ala Gln Ser Val Lys Ile Pro Arg Glu Pro Lys 
            180                 185                 190         


Ala Gly Glu Phe Asp Lys Ile Ile Arg Arg Leu Leu Glu Thr Ser Asn 
        195                 200                 205             


Ala Arg Ala Val Ile Ile Phe Ala Asn Glu Asp Asp Ile Arg Arg Val 
    210                 215                 220                 


Leu Glu Ala Ala Arg Arg Ala Asn Gln Thr Gly His Phe Phe Trp Met 
225                 230                 235                 240 


Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro Val Leu His Leu Glu 
                245                 250                 255     


Glu Val Ala Glu Gly Ala Val Thr Ile Leu Pro Lys Arg Met Ser Val 
            260                 265                 270         


Arg Asp Arg Glu Arg Ile Gly Gln Asp Ser Ala Tyr Glu Gln Glu Gly 
        275                 280                 285             


Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ala Met Gly His Ala Leu 
    290                 295                 300                 


His Ala Met His Arg Asp Leu Cys Pro Gly Arg Val Gly Leu Cys Pro 
305                 310                 315                 320 


Arg Met Asp Pro Val Asp Gly Thr Gln Leu Leu Lys Tyr Ile Arg Asn 
                325                 330                 335     


Val Asn Phe Ser Gly Ile Ala Gly Asn Pro Val Thr Phe Asn Glu Asn 
            340                 345                 350         


Gly Asp Ala Pro Gly Arg Tyr Asp Ile Tyr Gln Tyr Gln Leu Arg Asn 
        355                 360                 365             


Asp Ser Ala Glu Tyr Lys Val Ile Gly Ser Trp Thr Asp His Leu His 
    370                 375                 380                 


Leu Arg Ile Glu Arg Met His Trp Pro Gly Ser Gly Gln Gln Leu Pro 
385                 390                 395                 400 


Arg Ser Ile Cys Ser Leu Pro Cys Gln Pro Gly Glu Arg Lys Lys Thr 
                405                 410                 415     


Val Lys Gly Met Pro Cys Cys Trp His Cys Glu Pro Cys Thr Gly Tyr 
            420                 425                 430         


Gln Tyr Gln Val Asp Arg Tyr Thr Cys Lys Thr Cys Pro Tyr Asp Met 
        435                 440                 445             


Arg Pro Thr Glu Asn Arg Thr Gly Cys Arg Pro Ile Pro Ile Ile Lys 
    450                 455                 460                 


Leu Glu Trp Gly Ser Pro Trp Ala Val Leu Pro Leu Phe Leu Ala Val 
465                 470                 475                 480 


Val Gly Ile Ala Ala Thr Leu Phe Val Val Ile Thr Phe Val Arg Tyr 
                485                 490                 495     


Asn Asp Thr Pro Ile Val Lys Ala Ser Gly Arg Glu Leu Ser Tyr Val 
            500                 505                 510         


Leu Leu Ala Gly Ile Phe Leu Cys Tyr Ala Thr Thr Phe Leu Met Ile 
        515                 520                 525             


Ala Glu Pro Asp Leu Gly Thr Cys Ser Leu Arg Arg Ile Phe Leu Gly 
    530                 535                 540                 


Leu Gly Met Ser Ile Ser Tyr Ala Ala Leu Leu Thr Lys Thr Asn Arg 
545                 550                 555                 560 


Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val Ser Ala Pro Arg 
                565                 570                 575     


Phe Ile Ser Pro Ala Ser Gln Leu Ala Ile Thr Phe Ser Leu Ile Ser 
            580                 585                 590         


Leu Gln Leu Leu Gly Ile Cys Val Trp Phe Val Val Asp Pro Ser His 
        595                 600                 605             


Ser Val Val Asp Phe Gln Asp Gln Arg Thr Leu Asp Pro Arg Phe Ala 
    610                 615                 620                 


Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser Leu Ile Cys Leu 
625                 630                 635                 640 


Leu Gly Tyr Ser Met Leu Leu Met Val Thr Cys Thr Val Tyr Ala Ile 
                645                 650                 655     


Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro Ile Gly 
            660                 665                 670         


Phe Thr Met Tyr Thr Thr Cys Ile Val Trp Leu Ala Phe Ile Pro Ile 
        675                 680                 685             


Phe Phe Gly Thr Ser Gln Ser Ala Asp Lys Leu Tyr Ile Gln Thr Thr 
    690                 695                 700                 


Thr Leu Thr Val Ser Val Ser Leu Ser Ala Ser Val Ser Leu Gly Met 
705                 710                 715                 720 


Leu Tyr Met Pro Lys Val Tyr Ile Ile Leu Phe His Pro Glu Gln Asn 
                725                 730                 735     


Val Pro Lys Arg Lys Arg Ser Leu Lys Ala Val Val Thr Ala Ala Thr 
            740                 745                 750         


Met Ser Asn Lys Phe Thr Gln Lys Gly Asn Phe Arg Pro Asn Gly Glu 
        755                 760                 765             


Ala Lys Ser Glu Leu Cys Glu Asn Leu Glu Ala Pro Ala Leu Ala Thr 
    770                 775                 780                 


Lys Gln Thr Tyr Val Thr Tyr Thr Asn His Ala Ile 
785                 790                 795     


<210>  24
<211>  7996
<212>  DNA
<213>  Homo sapiens

<400>  24
gcgtctgccc gagcgcggca cgtgctcccg gcgctggcgc gagagagcga gcgccaccgc       60

cgcgggcccc gcagccgttc tgcctgctgt caccgctgcc tccatcgccg acactagcgc      120

tccagctgca gccaaggccg ctacgagagc gcaggaagcc ctcgaggagc ggctgcctgg      180

gggcgcaagg ctcagggcgc gcacctggtt tagaagatca tgaccacatg gatcatctaa      240

ctaaatggta catggggaca aaatggtcct ttagaaaata catctgaatt gctggctaat      300

ttcttgattt gcgactcaac gtaggacatc gcttgttcgt agctatcaga accctcctga      360

attttcccca ccatgctatc tttattggct tgaactcctt tcctaaaatg gtccttctgt      420

tgatcctgtc agtcttactt ttgaaagaag atgtccgtgg gagtgcacag tccagtgaga      480

ggagggtggt ggctcacatg ccgggtgaca tcattattgg agctctcttt tctgttcatc      540

accagcctac tgtggacaaa gttcatgaga ggaagtgtgg ggcggtccgt gaacagtatg      600

gcattcagag agtggaggcc atgctgcata ccctggaaag gatcaattca gaccccacac      660

tcttgcccaa catcacactg ggctgtgaga taagggactc ctgctggcat tcggctgtgg      720

ccctagagca gagcattgag ttcataagag attccctcat ttcttcagaa gaggaagaag      780

gcttggtacg ctgtgtggat ggctcctcct cttccttccg ctccaagaag cccatagtag      840

gggtcattgg gcctggctcc agttctgtag ccattcaggt ccagaatttg ctccagcttt      900

tcaacatacc tcagattgct tactcagcaa ccagcatgga tctgagtgac aagactctgt      960

tcaaatattt catgagggtt gtgccttcag atgctcagca ggcaagggcc atggtggaca     1020

tagtgaagag gtacaactgg acctatgtat cagccgtgca cacagaaggc aactatggag     1080

aaagtgggat ggaagccttc aaagatatgt cagcgaagga agggatttgc atcgcccact     1140

cttacaaaat ctacagtaat gcaggggagc agagctttga taagctgctg aagaagctca     1200

caagtcactt gcccaaggcc cgggtggtgg cctgcttctg tgagggcatg acggtgagag     1260

gtctgctgat ggccatgagg cgcctgggtc tagcgggaga atttctgctt ctgggcagtg     1320

atggctgggc tgacaggtat gatgtgacag atggatatca gcgagaagct gttggtggca     1380

tcacaatcaa gctccaatct cccgatgtca agtggtttga tgattattat ctgaagctcc     1440

ggccagaaac aaaccaccga aacccttggt ttcaagaatt ttggcagcat cgttttcagt     1500

gccgactgga agggtttcca caggagaaca gcaaatacaa caagacttgc aatagttctc     1560

tgactctgaa aacacatcat gttcaggatt ccaaaatggg atttgtgatc aacgccatct     1620

attcgatggc ctatgggctc cacaacatgc agatgtccct ctgcccaggc tatgcaggac     1680

tctgtgatgc catgaagcca attgatggac ggaaactttt ggagtccctg atgaaaacca     1740

attttactgg ggtttctgga gatacgatcc tattcgatga gaatggagac tctccaggaa     1800

ggtatgaaat aatgaatttc aaggaaatgg gaaaagatta ctttgattat atcaacgttg     1860

gaagttggga caatggagaa ttaaaaatgg atgatgatga agtatggtcc aagaaaagca     1920

acatcatcag atctgtgtgc agtgaaccat gtgagaaagg ccagatcaag gtgatccgaa     1980

agggagaagt cagctgttgt tggacctgta caccttgtaa ggagaatgag tatgtctttg     2040

atgagtacac atgcaaggca tgccaactgg ggtcttggcc cactgatgat ctcacaggtt     2100

gtgacttgat cccagtacag tatcttcgat ggggtgaccc tgaacccatt gcagctgtgg     2160

tgtttgcctg ccttggcctc ctggccaccc tgtttgttac tgtagtcttc atcatttacc     2220

gtgatacacc agtagtcaag tcctcaagca gggaactctg ctacattatc cttgctggca     2280

tctgcctggg ctacttatgt accttctgcc tcattgcgaa gcccaaacag atttactgct     2340

accttcagag aattggcatt ggtctctccc cagccatgag ctactcagcc cttgtaacaa     2400

agaccaaccg tattgcaagg atcctggctg gcagcaagaa gaagatctgt accaaaaagc     2460

ccagattcat gagtgcctgt gcccagctag tgattgcttt cattctcata tgcatccagt     2520

tgggcatcat cgttgccctc tttataatgg agcctcctga cataatgcat gactacccaa     2580

gcattcgaga agtctacctg atctgtaaca ccaccaacct aggagttgtc actccacttg     2640

gatacaatgg attgttgatt ttgagctgca ccttctatgc gttcaagacc agaaatgttc     2700

cagctaactt caacgaggcc aagtatatcg ccttcacaat gtacacgacc tgcattatat     2760

ggctagcttt tgtgccaatc tactttggca gcaactacaa aatcatcacc atgtgtttct     2820

cggtcagcct cagtgccaca gtggccctag gctgcatgtt tgtgccgaag gtgtacatca     2880

tcctggccaa accagagaga aacgtgcgca gcgccttcac cacatctacc gtggtgcgca     2940

tgcatgtagg ggatggcaag tcatcctccg cagccagcag atccagcagc ctagtcaacc     3000

tgtggaagag aaggggctcc tctggggaaa ccttaaggta caaagacagg agactggccc     3060

agcacaagtc ggaaatagag tgtttcaccc ccaaagggag tatggggaat ggtgggagag     3120

caacaatgag cagttccaat ggaaaatccg tcacgtgggc ccagaatgag aagagcagcc     3180

gggggcagca cctgtggcag cgcctgtcca tccacatcaa caagaaagaa aaccccaacc     3240

aaacggccgt catcaagccc ttccccaaga gcacggagag ccgtggcctg ggcgctggcg     3300

ctggcgcagg cgggagcgct gggggcgtgg gggccacggg cggtgcgggc tgcgcaggcg     3360

ccggcccagg cgggcccgag tccccagacg ccggccccaa ggcgctgtat gatgtggccg     3420

aggctgagga gcacttcccg gcgcccgcgc ggccgcgctc accgtcgccc atcagcacgc     3480

tgagccaccg cgcgggctcg gccagccgca cggacgacga tgtgccgtcg ctgcactcgg     3540

agcctgtggc gcgcagcagc tcctcgcagg gctccctcat ggagcagatc agcagtgtgg     3600

tcacccgctt cacggccaac atcagcgagc tcaactccat gatgctgtcc accgcggccc     3660

ccagccccgg cgtcggcgcc ccgctctgct cgtcctacct gatccccaaa gagatccagt     3720

tgcccacgac catgacgacc tttgccgaaa tccagcctct gccggccatc gaagtcacgg     3780

gaggcgcgca gcccgcggca ggggcgcagg cggctgggga cgcggcccgg gagagccccg     3840

cggccggtcc cgaggctgcg gccgccaagc cagacctgga ggagctggtg gctctcaccc     3900

cgccgtcccc cttcagagac tcggtggact cggggagcac aacccccaac tcgccagtgt     3960

ccgagtcggc cctctgtatc ccgtcgtctc ccaaatatga cactcttatc ataagagatt     4020

acactcagag ctcctcgtcg ttgtgaatgt ccctggaaag cacgccggcc tgcgcgtgcg     4080

gagcggagcc ccccgtgttc acacacacac aatggcaagc atagtcgcct ggttacggcc     4140

cagggggaag atgccaaggg caccccttaa tggaaacacg agatcagtag tgctatctca     4200

tgacaaccga cgaagaaacc gacgacaaat cttttggcag attttcttct agtggcctta     4260

gaaaacatgg gcttttaaga aacacggctg atatctttga gggctgacaa ggcgtctctt     4320

caaacagttc cataccaagt gctttgctct agggaagcag tgcgtgtgaa acagcgtaac     4380

ggagggtgaa gagcatagtt aataagcaac tgtaaaaagt tttatttgtt tactttaatt     4440

cttttcccag aagagtcttt gattcaccaa acatgaatgt acattttcta acaaactcaa     4500

aatctgggac caaaacatca acttttttct ttcttttttc tttctttttg ttttttcttt     4560

cctgtaaaga ccttgaaaag cagtaacttg ggtccagtat ttacggaggc gttgtgaatg     4620

tgtcccatgc ataacacact actggatagt gagtgctgcg ctaatgtact acgtagggct     4680

tctaccagag attttcctct ccaattgggt tgtgaaatac tcttccaaaa gcctgcatcg     4740

gggattccac ctacttattt cagattcacc tccattaacc aagaaaacca gtggaagatt     4800

tcttgactat ttcaccatgt tgccaatcaa tactggagta gcaaaaaaaa tattttctgg     4860

aatactgttt tgtaattccc tcactggggt gcattgtagc tggaaattct ctttataaaa     4920

atcattcttg agctccagcc tggctatctc tttcaagaaa catggccact ctttaggaat     4980

gctgttgcgt ttgcattgcc aactaaaata ttaaaatatg cattggggct tcttcattcc     5040

tttattttga gaacctgatg cacaaagagc tcctttgttc ttttcgagtc ccaccactgg     5100

aagagtggtc catagacccc atgaagacat tgtcatgatt tgagagactg ttgttgaaag     5160

gattaacaca atcttaatac actgaaaatt ttaactgtgt caagtcagct tagtggagat     5220

ttagctatgc cagtgagcag tgattttaac tattcttggc tgcttaaaca gggcagctat     5280

gaactatgac aaatgtagat ttttcaaagc aatacaaaat actaaaaaag aggaacctta     5340

atgaatatta accacacagt ctttcttagc cattccaaaa agaggcaaag caattcttat     5400

tttctttttt aaaataatga ttaatatgat tttgtgcact tcatactgtc actttttaaa     5460

actacagaaa agagatttag agtataacag aaacaagtgt gctttgatag tctcaaatag     5520

gtagaattca tagttcaaga cctgaatcca ctgtcatctc tttcttcctc ccattgcagc     5580

tatcctcagg taccaaatgt tttgattttt aaataaggat agtaataaat ggaggaggtg     5640

tcctataaat ttaaagttca gttgacccag ccttatactt aagatagcct tatgaaaaat     5700

atgtgctgtg aggcagaagt atattttggc agagagaata ataaataaaa ctttttcttt     5760

tagctcaata tccttacttt ggtaagtatt tttttttatt tcacatctac ttaacagaaa     5820

ataaactgag aaatagaagt cagtccattg gcataattta tcattcttca ctttaaaaaa     5880

ttctaataaa tattctgctt gagttttctt ttctgctatt tgttcttact tgcaacttta     5940

agtcaaacct cccaatacaa aacattaaaa gctaacatta atgtactaaa gtattaattt     6000

aaaagaaatc gaacctccca tgctagattt gaaaataaca tcatcacagc accctgatcc     6060

caaatattac accgaggctt ttaaaatgta agtgaaatct agctaagttt catggtttca     6120

ttaaaagcaa atgtctgcct ctatctgaaa aacaaatgga aatcttttga ggtgttaata     6180

ccctttggat cctcatcaaa aggatggcat tcacctgagg attcctatct tgacttctta     6240

ggtattaaaa acctttcttg atatgctcta cattttaaaa tttgttttat aaaatcctta     6300

tgttgatttt cattttattc tcaagtacaa tacgtttcac tctagaccag ttgaagaaca     6360

tgtttaaact ttgttcatgg tcaaattcat tttctatttt tttagtaaca tatctcttaa     6420

aaagcacact accttataaa aaacttcatc agaaattaaa tttaatgcaa gtaaattgcc     6480

atctgatact tccacatgct atcataatca actgtaataa taaaaatgat ttatccaatt     6540

agaaaaggac aagatatatt tttctctgta tttctataac ttttgccact ccattgaata     6600

cattgtatgt tggacataag attattagta atgcattctt gagatctttt attttggaat     6660

gatgctaact ctgtctcttt gccaattcta ataccaggtt ccaagtaata actctacagt     6720

acaaagagaa ctgaatattc attctagggc tataggatat gaacttcaca attcatttgg     6780

gtacattctc attgaatttc cttcaaaaca atctgttcct ggtgcccagt gataattcag     6840

tcgggaccag catgactaaa aggaagggga tatgctaagg ctcagcaaag tgaccctaaa     6900

tgagagatat gtcccaggat ggaaagaaga agacgtggtt taaccaagtt atactgacta     6960

atctaagcag tccactcatc cttccatttt gggaaaggag tgggggcagc ctaagaagaa     7020

catatctgga ttgggaagaa ccgtctttct gggctaggga tggggaacag aaagggagta     7080

tggaaagaaa aattataaga gatttgactg aagcaaggaa aaaaagcaaa tccccaaacg     7140

tgctaatcct tgaaagtaac tatctttccc aaactactgc tgttaccagc aagtgatcag     7200

gaagactagg agctatttct gactgtaaat gaattgtata atagctctgc tgcagttctg     7260

tgacttccaa gccaggaatt aaatgctctt tttaagaata acaaaaaaca aaagcatttc     7320

ctatgctagt ctcccagtaa aatgtacatg ttttggagac ttcaaaggta ttatgtgagt     7380

tcacatttag caacagctta ttaataaccc tcaagctgtc agaatctcta tagttaccat     7440

ttacaatttt atactgtgaa aaaatacaga tcagtgaaag cataaagaca agtcagaatt     7500

cactttgaag agggtctgag gcctgggaga gtctctactg tctattgaag aatgaggcat     7560

gtataaaata gttggttgaa tttcactgat cttcccaatg tgaacaaata tactatgtat     7620

attgtgtgta tttctagaaa tcaatggcag ctgctgatgg tgttgtaatt agaaatctat     7680

atagattata gatgttttag aaagatggtg ccaatcctaa aagatttgtg tgggctaaaa     7740

gtgcttgtac ttactttttt ctgcacttat aactgatttg gttttaaaat tgtgtgcgtg     7800

tatctgttct ttctctgttg tggcagcttg tactattaaa ataatagaga atgttaaatt     7860

attttgatgt gaactgcaaa tgattttttt tcataaagtt taacattttt atcagcattg     7920

ttttgctttg tacttgtata aatatgtttt attttagcac ttcaaaatat acttgcctgt     7980

ttctcagttg tctaaa                                                     7996


<210>  25
<211>  1212
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly 
    210                 215                 220                 


Glu Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile 
225                 230                 235                 240 


Cys Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser 
                245                 250                 255     


Phe Asp Lys Leu Leu Lys Lys Leu Thr Ser His Leu Pro Lys Ala Arg 
            260                 265                 270         


Val Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met 
        275                 280                 285             


Ala Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser 
    290                 295                 300                 


Asp Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu 
305                 310                 315                 320 


Ala Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp 
                325                 330                 335     


Phe Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn His Arg Asn 
            340                 345                 350         


Pro Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu 
        355                 360                 365             


Gly Phe Pro Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asn Ser Ser 
    370                 375                 380                 


Leu Thr Leu Lys Thr His His Val Gln Asp Ser Lys Met Gly Phe Val 
385                 390                 395                 400 


Ile Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met 
                405                 410                 415     


Ser Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile 
            420                 425                 430         


Asp Gly Arg Lys Leu Leu Glu Ser Leu Met Lys Thr Asn Phe Thr Gly 
        435                 440                 445             


Val Ser Gly Asp Thr Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly 
    450                 455                 460                 


Arg Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp 
465                 470                 475                 480 


Tyr Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp 
                485                 490                 495     


Asp Glu Val Trp Ser Lys Lys Ser Asn Ile Ile Arg Ser Val Cys Ser 
            500                 505                 510         


Glu Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val 
        515                 520                 525             


Ser Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe 
    530                 535                 540                 


Asp Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp 
545                 550                 555                 560 


Asp Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly 
                565                 570                 575     


Asp Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu 
            580                 585                 590         


Ala Thr Leu Phe Val Thr Val Val Phe Ile Ile Tyr Arg Asp Thr Pro 
        595                 600                 605             


Val Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly 
    610                 615                 620                 


Ile Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys 
625                 630                 635                 640 


Gln Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala 
                645                 650                 655     


Met Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile 
            660                 665                 670         


Leu Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met 
        675                 680                 685             


Ser Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln 
    690                 695                 700                 


Leu Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met 
705                 710                 715                 720 


His Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr 
                725                 730                 735     


Asn Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu 
            740                 745                 750         


Ser Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe 
        755                 760                 765             


Asn Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile 
    770                 775                 780                 


Trp Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile 
785                 790                 795                 800 


Thr Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys 
                805                 810                 815     


Met Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn 
            820                 825                 830         


Val Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly 
        835                 840                 845             


Asp Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn 
    850                 855                 860                 


Leu Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Arg Tyr Lys Asp 
865                 870                 875                 880 


Arg Arg Leu Ala Gln His Lys Ser Glu Ile Glu Cys Phe Thr Pro Lys 
                885                 890                 895     


Gly Ser Met Gly Asn Gly Gly Arg Ala Thr Met Ser Ser Ser Asn Gly 
            900                 905                 910         


Lys Ser Val Thr Trp Ala Gln Asn Glu Lys Ser Ser Arg Gly Gln His 
        915                 920                 925             


Leu Trp Gln Arg Leu Ser Ile His Ile Asn Lys Lys Glu Asn Pro Asn 
    930                 935                 940                 


Gln Thr Ala Val Ile Lys Pro Phe Pro Lys Ser Thr Glu Ser Arg Gly 
945                 950                 955                 960 


Leu Gly Ala Gly Ala Gly Ala Gly Gly Ser Ala Gly Gly Val Gly Ala 
                965                 970                 975     


Thr Gly Gly Ala Gly Cys Ala Gly Ala Gly Pro Gly Gly Pro Glu Ser 
            980                 985                 990         


Pro Asp Ala Gly Pro Lys Ala Leu  Tyr Asp Val Ala Glu  Ala Glu Glu 
        995                 1000                 1005             


His Phe  Pro Ala Pro Ala Arg  Pro Arg Ser Pro Ser  Pro Ile Ser 
    1010                 1015                 1020             


Thr Leu  Ser His Arg Ala Gly  Ser Ala Ser Arg Thr  Asp Asp Asp 
    1025                 1030                 1035             


Val Pro  Ser Leu His Ser Glu  Pro Val Ala Arg Ser  Ser Ser Ser 
    1040                 1045                 1050             


Gln Gly  Ser Leu Met Glu Gln  Ile Ser Ser Val Val  Thr Arg Phe 
    1055                 1060                 1065             


Thr Ala  Asn Ile Ser Glu Leu  Asn Ser Met Met Leu  Ser Thr Ala 
    1070                 1075                 1080             


Ala Pro  Ser Pro Gly Val Gly  Ala Pro Leu Cys Ser  Ser Tyr Leu 
    1085                 1090                 1095             


Ile Pro  Lys Glu Ile Gln Leu  Pro Thr Thr Met Thr  Thr Phe Ala 
    1100                 1105                 1110             


Glu Ile  Gln Pro Leu Pro Ala  Ile Glu Val Thr Gly  Gly Ala Gln 
    1115                 1120                 1125             


Pro Ala  Ala Gly Ala Gln Ala  Ala Gly Asp Ala Ala  Arg Glu Ser 
    1130                 1135                 1140             


Pro Ala  Ala Gly Pro Glu Ala  Ala Ala Ala Lys Pro  Asp Leu Glu 
    1145                 1150                 1155             


Glu Leu  Val Ala Leu Thr Pro  Pro Ser Pro Phe Arg  Asp Ser Val 
    1160                 1165                 1170             


Asp Ser  Gly Ser Thr Thr Pro  Asn Ser Pro Val Ser  Glu Ser Ala 
    1175                 1180                 1185             


Leu Cys  Ile Pro Ser Ser Pro  Lys Tyr Asp Thr Leu  Ile Ile Arg 
    1190                 1195                 1200             


Asp Tyr  Thr Gln Ser Ser Ser  Ser Leu 
    1205                 1210         


<210>  26
<211>  7900
<212>  DNA
<213>  Homo sapiens

<400>  26
gcgtctgccc gagcgcggca cgtgctcccg gcgctggcgc gagagagcga gcgccaccgc       60

cgcgggcccc gcagccgttc tgcctgctgt caccgctgcc tccatcgccg acactagcgc      120

tccagctgca gccaaggccg ctacgagagc gcaggaagcc ctcgaggagc ggctgcctgg      180

gggcgcaagg ctcagggcgc gcacctggtt tagaagatca tgaccacatg gatcatctaa      240

ctaaatggta catggggaca aaatggtcct ttagaaaata catctgaatt gctggctaat      300

ttcttgattt gcgactcaac gtaggacatc gcttgttcgt agctatcaga accctcctga      360

attttcccca ccatgctatc tttattggct tgaactcctt tcctaaaatg gtccttctgt      420

tgatcctgtc agtcttactt ttgaaagaag atgtccgtgg gagtgcacag tccagtgaga      480

ggagggtggt ggctcacatg ccgggtgaca tcattattgg agctctcttt tctgttcatc      540

accagcctac tgtggacaaa gttcatgaga ggaagtgtgg ggcggtccgt gaacagtatg      600

gcattcagag agtggaggcc atgctgcata ccctggaaag gatcaattca gaccccacac      660

tcttgcccaa catcacactg ggctgtgaga taagggactc ctgctggcat tcggctgtgg      720

ccctagagca gagcattgag ttcataagag attccctcat ttcttcagaa gaggaagaag      780

gcttggtacg ctgtgtggat ggctcctcct cttccttccg ctccaagaag cccatagtag      840

gggtcattgg gcctggctcc agttctgtag ccattcaggt ccagaatttg ctccagcttt      900

tcaacatacc tcagattgct tactcagcaa ccagcatgga tctgagtgac aagactctgt      960

tcaaatattt catgagggtt gtgccttcag atgctcagca ggcaagggcc atggtggaca     1020

tagtgaagag gtacaactgg acctatgtat cagccgtgca cacagaaggc aactatggag     1080

aaagtgggat ggaagccttc aaagatatgt cagcgaagga agggatttgc atcgcccact     1140

cttacaaaat ctacagtaat gcaggggagc agagctttga taagctgctg aagaagctca     1200

caagtcactt gcccaaggcc cgggtggtgg cctgcttctg tgagggcatg acggtgagag     1260

gtctgctgat ggccatgagg cgcctgggtc tagcgggaga atttctgctt ctgggcagtg     1320

atggctgggc tgacaggtat gatgtgacag atggatatca gcgagaagct gttggtggca     1380

tcacaatcaa gctccaatct cccgatgtca agtggtttga tgattattat ctgaagctcc     1440

ggccagaaac aaaccaccga aacccttggt ttcaagaatt ttggcagcat cgttttcagt     1500

gccgactgga agggtttcca caggagaaca gcaaatacaa caagacttgc aatagttctc     1560

tgactctgaa aacacatcat gttcaggatt ccaaaatggg atttgtgatc aacgccatct     1620

attcgatggc ctatgggctc cacaacatgc agatgtccct ctgcccaggc tatgcaggac     1680

tctgtgatgc catgaagcca attgatggac ggaaactttt ggagtccctg atgaaaacca     1740

attttactgg ggtttctgga gatacgatcc tattcgatga gaatggagac tctccaggaa     1800

ggtatgaaat aatgaatttc aaggaaatgg gaaaagatta ctttgattat atcaacgttg     1860

gaagttggga caatggagaa ttaaaaatgg atgatgatga agtatggtcc aagaaaagca     1920

acatcatcag atctgtgtgc agtgaaccat gtgagaaagg ccagatcaag gtgatccgaa     1980

agggagaagt cagctgttgt tggacctgta caccttgtaa ggagaatgag tatgtctttg     2040

atgagtacac atgcaaggca tgccaactgg ggtcttggcc cactgatgat ctcacaggtt     2100

gtgacttgat cccagtacag tatcttcgat ggggtgaccc tgaacccatt gcagctgtgg     2160

tgtttgcctg ccttggcctc ctggccaccc tgtttgttac tgtagtcttc atcatttacc     2220

gtgatacacc agtagtcaag tcctcaagca gggaactctg ctacattatc cttgctggca     2280

tctgcctggg ctacttatgt accttctgcc tcattgcgaa gcccaaacag atttactgct     2340

accttcagag aattggcatt ggtctctccc cagccatgag ctactcagcc cttgtaacaa     2400

agaccaaccg tattgcaagg atcctggctg gcagcaagaa gaagatctgt accaaaaagc     2460

ccagattcat gagtgcctgt gcccagctag tgattgcttt cattctcata tgcatccagt     2520

tgggcatcat cgttgccctc tttataatgg agcctcctga cataatgcat gactacccaa     2580

gcattcgaga agtctacctg atctgtaaca ccaccaacct aggagttgtc actccacttg     2640

gatacaatgg attgttgatt ttgagctgca ccttctatgc gttcaagacc agaaatgttc     2700

cagctaactt caacgaggcc aagtatatcg ccttcacaat gtacacgacc tgcattatat     2760

ggctagcttt tgtgccaatc tactttggca gcaactacaa aatcatcacc atgtgtttct     2820

cggtcagcct cagtgccaca gtggccctag gctgcatgtt tgtgccgaag gtgtacatca     2880

tcctggccaa accagagaga aacgtgcgca gcgccttcac cacatctacc gtggtgcgca     2940

tgcatgtagg ggatggcaag tcatcctccg cagccagcag atccagcagc ctagtcaacc     3000

tgtggaagag aaggggctcc tctggggaaa ccttaagttc caatggaaaa tccgtcacgt     3060

gggcccagaa tgagaagagc agccgggggc agcacctgtg gcagcgcctg tccatccaca     3120

tcaacaagaa agaaaacccc aaccaaacgg ccgtcatcaa gcccttcccc aagagcacgg     3180

agagccgtgg cctgggcgct ggcgctggcg caggcgggag cgctgggggc gtgggggcca     3240

cgggcggtgc gggctgcgca ggcgccggcc caggcgggcc cgagtcccca gacgccggcc     3300

ccaaggcgct gtatgatgtg gccgaggctg aggagcactt cccggcgccc gcgcggccgc     3360

gctcaccgtc gcccatcagc acgctgagcc accgcgcggg ctcggccagc cgcacggacg     3420

acgatgtgcc gtcgctgcac tcggagcctg tggcgcgcag cagctcctcg cagggctccc     3480

tcatggagca gatcagcagt gtggtcaccc gcttcacggc caacatcagc gagctcaact     3540

ccatgatgct gtccaccgcg gcccccagcc ccggcgtcgg cgccccgctc tgctcgtcct     3600

acctgatccc caaagagatc cagttgccca cgaccatgac gacctttgcc gaaatccagc     3660

ctctgccggc catcgaagtc acgggaggcg cgcagcccgc ggcaggggcg caggcggctg     3720

gggacgcggc ccgggagagc cccgcggccg gtcccgaggc tgcggccgcc aagccagacc     3780

tggaggagct ggtggctctc accccgccgt cccccttcag agactcggtg gactcgggga     3840

gcacaacccc caactcgcca gtgtccgagt cggccctctg tatcccgtcg tctcccaaat     3900

atgacactct tatcataaga gattacactc agagctcctc gtcgttgtga atgtccctgg     3960

aaagcacgcc ggcctgcgcg tgcggagcgg agccccccgt gttcacacac acacaatggc     4020

aagcatagtc gcctggttac ggcccagggg gaagatgcca agggcacccc ttaatggaaa     4080

cacgagatca gtagtgctat ctcatgacaa ccgacgaaga aaccgacgac aaatcttttg     4140

gcagattttc ttctagtggc cttagaaaac atgggctttt aagaaacacg gctgatatct     4200

ttgagggctg acaaggcgtc tcttcaaaca gttccatacc aagtgctttg ctctagggaa     4260

gcagtgcgtg tgaaacagcg taacggaggg tgaagagcat agttaataag caactgtaaa     4320

aagttttatt tgtttacttt aattcttttc ccagaagagt ctttgattca ccaaacatga     4380

atgtacattt tctaacaaac tcaaaatctg ggaccaaaac atcaactttt ttctttcttt     4440

tttctttctt tttgtttttt ctttcctgta aagaccttga aaagcagtaa cttgggtcca     4500

gtatttacgg aggcgttgtg aatgtgtccc atgcataaca cactactgga tagtgagtgc     4560

tgcgctaatg tactacgtag ggcttctacc agagattttc ctctccaatt gggttgtgaa     4620

atactcttcc aaaagcctgc atcggggatt ccacctactt atttcagatt cacctccatt     4680

aaccaagaaa accagtggaa gatttcttga ctatttcacc atgttgccaa tcaatactgg     4740

agtagcaaaa aaaatatttt ctggaatact gttttgtaat tccctcactg gggtgcattg     4800

tagctggaaa ttctctttat aaaaatcatt cttgagctcc agcctggcta tctctttcaa     4860

gaaacatggc cactctttag gaatgctgtt gcgtttgcat tgccaactaa aatattaaaa     4920

tatgcattgg ggcttcttca ttcctttatt ttgagaacct gatgcacaaa gagctccttt     4980

gttcttttcg agtcccacca ctggaagagt ggtccataga ccccatgaag acattgtcat     5040

gatttgagag actgttgttg aaaggattaa cacaatctta atacactgaa aattttaact     5100

gtgtcaagtc agcttagtgg agatttagct atgccagtga gcagtgattt taactattct     5160

tggctgctta aacagggcag ctatgaacta tgacaaatgt agatttttca aagcaataca     5220

aaatactaaa aaagaggaac cttaatgaat attaaccaca cagtctttct tagccattcc     5280

aaaaagaggc aaagcaattc ttattttctt ttttaaaata atgattaata tgattttgtg     5340

cacttcatac tgtcactttt taaaactaca gaaaagagat ttagagtata acagaaacaa     5400

gtgtgctttg atagtctcaa ataggtagaa ttcatagttc aagacctgaa tccactgtca     5460

tctctttctt cctcccattg cagctatcct caggtaccaa atgttttgat ttttaaataa     5520

ggatagtaat aaatggagga ggtgtcctat aaatttaaag ttcagttgac ccagccttat     5580

acttaagata gccttatgaa aaatatgtgc tgtgaggcag aagtatattt tggcagagag     5640

aataataaat aaaacttttt cttttagctc aatatcctta ctttggtaag tatttttttt     5700

tatttcacat ctacttaaca gaaaataaac tgagaaatag aagtcagtcc attggcataa     5760

tttatcattc ttcactttaa aaaattctaa taaatattct gcttgagttt tcttttctgc     5820

tatttgttct tacttgcaac tttaagtcaa acctcccaat acaaaacatt aaaagctaac     5880

attaatgtac taaagtatta atttaaaaga aatcgaacct cccatgctag atttgaaaat     5940

aacatcatca cagcaccctg atcccaaata ttacaccgag gcttttaaaa tgtaagtgaa     6000

atctagctaa gtttcatggt ttcattaaaa gcaaatgtct gcctctatct gaaaaacaaa     6060

tggaaatctt ttgaggtgtt aatacccttt ggatcctcat caaaaggatg gcattcacct     6120

gaggattcct atcttgactt cttaggtatt aaaaaccttt cttgatatgc tctacatttt     6180

aaaatttgtt ttataaaatc cttatgttga ttttcatttt attctcaagt acaatacgtt     6240

tcactctaga ccagttgaag aacatgttta aactttgttc atggtcaaat tcattttcta     6300

tttttttagt aacatatctc ttaaaaagca cactacctta taaaaaactt catcagaaat     6360

taaatttaat gcaagtaaat tgccatctga tacttccaca tgctatcata atcaactgta     6420

ataataaaaa tgatttatcc aattagaaaa ggacaagata tatttttctc tgtatttcta     6480

taacttttgc cactccattg aatacattgt atgttggaca taagattatt agtaatgcat     6540

tcttgagatc ttttattttg gaatgatgct aactctgtct ctttgccaat tctaatacca     6600

ggttccaagt aataactcta cagtacaaag agaactgaat attcattcta gggctatagg     6660

atatgaactt cacaattcat ttgggtacat tctcattgaa tttccttcaa aacaatctgt     6720

tcctggtgcc cagtgataat tcagtcggga ccagcatgac taaaaggaag gggatatgct     6780

aaggctcagc aaagtgaccc taaatgagag atatgtccca ggatggaaag aagaagacgt     6840

ggtttaacca agttatactg actaatctaa gcagtccact catccttcca ttttgggaaa     6900

ggagtggggg cagcctaaga agaacatatc tggattggga agaaccgtct ttctgggcta     6960

gggatgggga acagaaaggg agtatggaaa gaaaaattat aagagatttg actgaagcaa     7020

ggaaaaaaag caaatcccca aacgtgctaa tccttgaaag taactatctt tcccaaacta     7080

ctgctgttac cagcaagtga tcaggaagac taggagctat ttctgactgt aaatgaattg     7140

tataatagct ctgctgcagt tctgtgactt ccaagccagg aattaaatgc tctttttaag     7200

aataacaaaa aacaaaagca tttcctatgc tagtctccca gtaaaatgta catgttttgg     7260

agacttcaaa ggtattatgt gagttcacat ttagcaacag cttattaata accctcaagc     7320

tgtcagaatc tctatagtta ccatttacaa ttttatactg tgaaaaaata cagatcagtg     7380

aaagcataaa gacaagtcag aattcacttt gaagagggtc tgaggcctgg gagagtctct     7440

actgtctatt gaagaatgag gcatgtataa aatagttggt tgaatttcac tgatcttccc     7500

aatgtgaaca aatatactat gtatattgtg tgtatttcta gaaatcaatg gcagctgctg     7560

atggtgttgt aattagaaat ctatatagat tatagatgtt ttagaaagat ggtgccaatc     7620

ctaaaagatt tgtgtgggct aaaagtgctt gtacttactt ttttctgcac ttataactga     7680

tttggtttta aaattgtgtg cgtgtatctg ttctttctct gttgtggcag cttgtactat     7740

taaaataata gagaatgtta aattattttg atgtgaactg caaatgattt tttttcataa     7800

agtttaacat ttttatcagc attgttttgc tttgtacttg tataaatatg ttttatttta     7860

gcacttcaaa atatacttgc ctgtttctca gttgtctaaa                           7900


<210>  27
<211>  1180
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly 
    210                 215                 220                 


Glu Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile 
225                 230                 235                 240 


Cys Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser 
                245                 250                 255     


Phe Asp Lys Leu Leu Lys Lys Leu Thr Ser His Leu Pro Lys Ala Arg 
            260                 265                 270         


Val Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met 
        275                 280                 285             


Ala Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser 
    290                 295                 300                 


Asp Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu 
305                 310                 315                 320 


Ala Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp 
                325                 330                 335     


Phe Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn His Arg Asn 
            340                 345                 350         


Pro Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu 
        355                 360                 365             


Gly Phe Pro Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asn Ser Ser 
    370                 375                 380                 


Leu Thr Leu Lys Thr His His Val Gln Asp Ser Lys Met Gly Phe Val 
385                 390                 395                 400 


Ile Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met 
                405                 410                 415     


Ser Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile 
            420                 425                 430         


Asp Gly Arg Lys Leu Leu Glu Ser Leu Met Lys Thr Asn Phe Thr Gly 
        435                 440                 445             


Val Ser Gly Asp Thr Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly 
    450                 455                 460                 


Arg Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp 
465                 470                 475                 480 


Tyr Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp 
                485                 490                 495     


Asp Glu Val Trp Ser Lys Lys Ser Asn Ile Ile Arg Ser Val Cys Ser 
            500                 505                 510         


Glu Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val 
        515                 520                 525             


Ser Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe 
    530                 535                 540                 


Asp Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp 
545                 550                 555                 560 


Asp Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly 
                565                 570                 575     


Asp Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu 
            580                 585                 590         


Ala Thr Leu Phe Val Thr Val Val Phe Ile Ile Tyr Arg Asp Thr Pro 
        595                 600                 605             


Val Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly 
    610                 615                 620                 


Ile Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys 
625                 630                 635                 640 


Gln Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala 
                645                 650                 655     


Met Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile 
            660                 665                 670         


Leu Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met 
        675                 680                 685             


Ser Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln 
    690                 695                 700                 


Leu Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met 
705                 710                 715                 720 


His Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr 
                725                 730                 735     


Asn Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu 
            740                 745                 750         


Ser Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe 
        755                 760                 765             


Asn Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile 
    770                 775                 780                 


Trp Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile 
785                 790                 795                 800 


Thr Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys 
                805                 810                 815     


Met Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn 
            820                 825                 830         


Val Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly 
        835                 840                 845             


Asp Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn 
    850                 855                 860                 


Leu Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Ser Ser Asn Gly 
865                 870                 875                 880 


Lys Ser Val Thr Trp Ala Gln Asn Glu Lys Ser Ser Arg Gly Gln His 
                885                 890                 895     


Leu Trp Gln Arg Leu Ser Ile His Ile Asn Lys Lys Glu Asn Pro Asn 
            900                 905                 910         


Gln Thr Ala Val Ile Lys Pro Phe Pro Lys Ser Thr Glu Ser Arg Gly 
        915                 920                 925             


Leu Gly Ala Gly Ala Gly Ala Gly Gly Ser Ala Gly Gly Val Gly Ala 
    930                 935                 940                 


Thr Gly Gly Ala Gly Cys Ala Gly Ala Gly Pro Gly Gly Pro Glu Ser 
945                 950                 955                 960 


Pro Asp Ala Gly Pro Lys Ala Leu Tyr Asp Val Ala Glu Ala Glu Glu 
                965                 970                 975     


His Phe Pro Ala Pro Ala Arg Pro Arg Ser Pro Ser Pro Ile Ser Thr 
            980                 985                 990         


Leu Ser His Arg Ala Gly Ser Ala  Ser Arg Thr Asp Asp  Asp Val Pro 
        995                 1000                 1005             


Ser Leu  His Ser Glu Pro Val  Ala Arg Ser Ser Ser  Ser Gln Gly 
    1010                 1015                 1020             


Ser Leu  Met Glu Gln Ile Ser  Ser Val Val Thr Arg  Phe Thr Ala 
    1025                 1030                 1035             


Asn Ile  Ser Glu Leu Asn Ser  Met Met Leu Ser Thr  Ala Ala Pro 
    1040                 1045                 1050             


Ser Pro  Gly Val Gly Ala Pro  Leu Cys Ser Ser Tyr  Leu Ile Pro 
    1055                 1060                 1065             


Lys Glu  Ile Gln Leu Pro Thr  Thr Met Thr Thr Phe  Ala Glu Ile 
    1070                 1075                 1080             


Gln Pro  Leu Pro Ala Ile Glu  Val Thr Gly Gly Ala  Gln Pro Ala 
    1085                 1090                 1095             


Ala Gly  Ala Gln Ala Ala Gly  Asp Ala Ala Arg Glu  Ser Pro Ala 
    1100                 1105                 1110             


Ala Gly  Pro Glu Ala Ala Ala  Ala Lys Pro Asp Leu  Glu Glu Leu 
    1115                 1120                 1125             


Val Ala  Leu Thr Pro Pro Ser  Pro Phe Arg Asp Ser  Val Asp Ser 
    1130                 1135                 1140             


Gly Ser  Thr Thr Pro Asn Ser  Pro Val Ser Glu Ser  Ala Leu Cys 
    1145                 1150                 1155             


Ile Pro  Ser Ser Pro Lys Tyr  Asp Thr Leu Ile Ile  Arg Asp Tyr 
    1160                 1165                 1170             


Thr Gln  Ser Ser Ser Ser Leu  
    1175                 1180 


<210>  28

<400>  28
000

<210>  29
<211>  942
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly 
    210                 215                 220                 


Glu Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile 
225                 230                 235                 240 


Cys Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser 
                245                 250                 255     


Phe Asp Lys Leu Leu Lys Lys Leu Thr Ser His Leu Pro Lys Ala Arg 
            260                 265                 270         


Val Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met 
        275                 280                 285             


Ala Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser 
    290                 295                 300                 


Asp Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu 
305                 310                 315                 320 


Ala Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp 
                325                 330                 335     


Phe Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn His Arg Asn 
            340                 345                 350         


Pro Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu 
        355                 360                 365             


Gly Phe Pro Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asn Ser Ser 
    370                 375                 380                 


Leu Thr Leu Lys Thr His His Val Gln Asp Ser Lys Met Gly Phe Val 
385                 390                 395                 400 


Ile Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met 
                405                 410                 415     


Ser Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile 
            420                 425                 430         


Asp Gly Arg Lys Leu Leu Glu Ser Leu Met Lys Thr Asn Phe Thr Gly 
        435                 440                 445             


Val Ser Gly Asp Thr Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly 
    450                 455                 460                 


Arg Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp 
465                 470                 475                 480 


Tyr Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp 
                485                 490                 495     


Asp Glu Val Trp Ser Lys Lys Ser Asn Ile Ile Arg Ser Val Cys Ser 
            500                 505                 510         


Glu Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val 
        515                 520                 525             


Ser Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe 
    530                 535                 540                 


Asp Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp 
545                 550                 555                 560 


Asp Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly 
                565                 570                 575     


Asp Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu 
            580                 585                 590         


Ala Thr Leu Phe Val Thr Val Val Phe Ile Ile Tyr Arg Asp Thr Pro 
        595                 600                 605             


Val Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly 
    610                 615                 620                 


Ile Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys 
625                 630                 635                 640 


Gln Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala 
                645                 650                 655     


Met Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile 
            660                 665                 670         


Leu Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met 
        675                 680                 685             


Ser Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln 
    690                 695                 700                 


Leu Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met 
705                 710                 715                 720 


His Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr 
                725                 730                 735     


Asn Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu 
            740                 745                 750         


Ser Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe 
        755                 760                 765             


Asn Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile 
    770                 775                 780                 


Trp Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile 
785                 790                 795                 800 


Thr Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys 
                805                 810                 815     


Met Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn 
            820                 825                 830         


Val Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly 
        835                 840                 845             


Asp Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn 
    850                 855                 860                 


Leu Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Arg Tyr Lys Asp 
865                 870                 875                 880 


Arg Arg Leu Ala Gln His Lys Ser Glu Ile Glu Cys Phe Thr Pro Pro 
                885                 890                 895     


Ser Pro Phe Arg Asp Ser Val Asp Ser Gly Ser Thr Thr Pro Asn Ser 
            900                 905                 910         


Pro Val Ser Glu Ser Ala Leu Cys Ile Pro Ser Ser Pro Lys Tyr Asp 
        915                 920                 925             


Thr Leu Ile Ile Arg Asp Tyr Thr Gln Ser Ser Ser Ser Leu 
    930                 935                 940         


<210>  30
<211>  6143
<212>  DNA
<213>  Homo sapiens

<400>  30
cggaggcccg ggcaggccgg ctgagctaac tccccagagc cgaagtggaa ggcgcgcccc       60

gagcgccttc tccccaggac cccggtgtcc ctccccgcgc cccgagcccg cgctctcctt      120

cccccgccct cagagcgctc cccgcccctc tgtctccccg cagcccgcta gacgagccga      180

tggcgcggcc ccggagagcc cgggagccgc tgctcgtggc gctgctgccg ctggcgtggc      240

tggcgcaggc gggcctggcg cgcgcggcgg gctctgtgcg cctggcgggc ggcctgacgc      300

tgggcggcct gttcccggtg cacgcgcggg gcgcggcggg ccgggcgtgc gggcagctga      360

agaaggagca gggcgtgcac cggctggagg ccatgctgta cgcgctggac cgcgtcaacg      420

ccgaccccga gctgctgccc ggcgtgcgcc tgggcgcgcg gctgctggac acctgctcgc      480

gggacaccta cgcgctggag caggcgctga gcttcgtgca ggcgctgatc cgcggccgcg      540

gcgacggcga cgaggtgggc gtgcgctgcc cgggaggcgt ccctccgctg cgccccgcgc      600

cccccgagcg cgtcgtggcc gtcgtgggcg cctcggccag ctccgtctcc atcatggtcg      660

ccaacgtgct gcgcctgttt gcgatacccc agatcagcta tgcctccaca gccccggagc      720

tcagcgactc cacacgctat gacttcttct cccgggtggt gccacccgac tcctaccagg      780

cgcaggccat ggtggacatc gtgagggcac tgggatggaa ctatgtgtcc acgctggcct      840

ccgagggcaa ctatggcgaa agtggggttg aggccttcgt tcagatctcc cgagaggctg      900

ggggggtctg tattgcccag tctatcaaga ttcccaggga accaaagcca ggagagttca      960

gcaaggtgat caggagactc atggagacgc ccaacgcccg gggcatcatc atctttgcca     1020

atgaggatga catcaggcgg gtcctggagg cagctcgcca ggccaacctg accggccact     1080

tcctgtgggt cggctcagac agctggggag ccaagacctc acccatcttg agcctggagg     1140

acgtggccgt tggggccatc accatcctgc ccaaaagggc ctccatcgac ggatttgacc     1200

agtacttcat gactcgatcc ctggagaaca accgcaggaa catctggttc gccgagttct     1260

gggaagagaa ttttaactgc aaactgacca gctcaggtac ccagtcagac gattccaccc     1320

gcaaatgcac aggcgaggaa cgcatcggcc gggactccac ctacgagcag gagggcaagg     1380

tgcagtttgt gattgatgcg gtgtacgcca ttgcccacgc cctccacagc atgcaccagg     1440

cgctctgccc tgggcacaca ggcctgtgcc cggcgatgga acccactgat gggcggatgc     1500

ttctgcagta cattcgagct gtccgcttca atggcagcgc aggaacccct gtgatgttca     1560

acgagaacgg agatgcgccc gggcggtacg acatcttcca gtaccaggcg accaatggca     1620

gtgccagcag tggcgggtac caggcagtgg gccagtgggc agagaccctc agactggatg     1680

tggaggccct gcagtggtct ggcgaccccc acgaggtgcc ctcgtctctg tgcagcctgc     1740

cctgcgggcc gggggagcgg aagaagatgg tgaagggcgt cccctgctgt tggcactgcg     1800

aggcctgtga cgggtaccgc ttccaggtgg acgagttcac atgcgaggcc tgtcctgggg     1860

acatgaggcc cacgcccaac cacacgggct gccgccccac acctgtggtg cgcctgagct     1920

ggtcctcccc ctgggcagcc ccgccgctcc tcctggccgt gctgggcatc gtggccacta     1980

ccacggtggt ggccaccttc gtgcggtaca acaacacgcc catcgtccgg gcctcgggcc     2040

gagagctcag ctacgtcctc ctcaccggca tcttcctcat ctacgccatc accttcctca     2100

tggtggctga gcctggggcc gcggtctgtg ccgcccgcag gctcttcctg ggcctgggca     2160

cgaccctcag ctactctgcc ctgctcacca agaccaaccg tatctaccgc atctttgagc     2220

agggcaagcg ctcggtcaca ccccctccct tcatcagccc cacctcacag ctggtcatca     2280

ccttcagcct cacctccctg caggtggtgg ggatgatagc atggctgggg gcccggcccc     2340

cacacagcgt gattgactat gaggaacagc ggacggtgga ccccgagcag gccagagggg     2400

tgctcaagtg cgacatgtcg gatctgtctc tcatcggctg cctgggctac agcctcctgc     2460

tcatggtcac gtgcacagtg tacgccatca aggcccgtgg cgtgcccgag accttcaacg     2520

aggccaagcc catcggcttc accatgtaca ccacctgcat catctggctg gcattcgtgc     2580

ccatcttctt tggcactgcc cagtcagctg aaaagatcta catccagaca accacgctaa     2640

ccgtgtcctt gagcctgagt gcctcggtgt ccctcggcat gctctacgta cccaaaacct     2700

acgtcatcct cttccatcca gagcagaatg tgcagaagcg aaagcggagc ctcaaggcca     2760

cctccacggt ggcagcccca cccaagggcg aggatgcaga ggcccacaag tagcagggca     2820

ggtgggaacg ggactgcttg ctgcctctcc tttcttcctc ttgcctcgag gtggaagctg     2880

tatagagccc gggtccacgg tgaacagtca gtggcaggga gtttgccaag accatgctcc     2940

gcgtcggtgg ggctggcctt gagaaggaac tggacccagc tctaccccga ttccagcatg     3000

tgagcttcat gcttcctcac cacagaccag actcgcttcc catggtggga aacagccacc     3060

gagaaggttc tagctctaga aagggactaa acttattctc tcatccgaag tccaaagagg     3120

atgatgaagc cctgggcttt gcctggtttg cgggagattt cctcccctca gtcaaccccc     3180

ataacctggg gattgggcag tgtggaagaa cgtgtagacc ccagaatgaa acatggggtt     3240

ggagtggagg aggagctgtc tcagcaagag gagacctggg gctgtgcatc tggatggagg     3300

cactcaggcc tgggtaggat tcctctggca cggagggaga gaccctgggt gagacccctg     3360

tgagcatggg aagggcctgc agtgggcgcg ggagtgagct gaggaactgg ggtgcgcccc     3420

catgagattc ccaatgccat gggctttccc ccatcccccc gggattgggc aaggtcagac     3480

ttagagtaca gctgttttcc tcccctctgt gtactccctt aaatcacccc aaccttggcc     3540

aggcatggtg gctcacacct gtaatcccag cactttggga ggccgaggca ggtggatcac     3600

ctgaggtccg gagttcgaga ccagcctggc caatgtggtg aaaccctgtc tctactaaaa     3660

atacaaaaat tagccaggtg tgatggtggg tgcctgtaat cccagttact tgggaggctg     3720

aggcaggaga atcgcttgaa cctgggaggt ggaggttgca gtgagctgtg attgtgccac     3780

tgtactccag cctgggtgac agagcgagac tctgtctcaa aaaaacaaaa caaaaaaaca     3840

ccaaaaaaac ccccaaacct gaagaaattc agatacacgt gtgtaatgtt agtgatgtga     3900

gaacaaggag caggggtgca tttgtgttgt gttcgggttg gggatgggtt taggagctcc     3960

aggttgggag cagtgacaga gagtcatggc cgtggtgagg gtgaatccca agtggatggc     4020

tcaggacggg tatggaaacc cttcattcct cataggtact gggaagtcca tttgcaagct     4080

gagcgccagg cctggggagg aagaggcttg ggctgcagat gcacgcacat ttgtttttca     4140

ctgatagttt ttacaaaaag cttggtttaa gttatggagt tttatgtccc tgggagtaga     4200

atttacattt gttaaattga ccactgttta agatcagtat acattctcta gtctgtgatg     4260

tctggagcta gttttgaggg tgaaccacac tttatccaac atacaaactt tcccatgcag     4320

cttctctggt gcgcagttgg ttttgaccgt gggactaggt gcttctgcag gttttaagta     4380

attaacttaa aagcttctcc tctgagaaac atttctgttg cgctactgac tctccttctc     4440

cacatttgtt gtgttcctag ggcttctcta tagtgcacat taggacgttt catttgttgc     4500

tgaatgcttt ccagaattat ttattccata gggtttctct cctgtgcagc tctctcatgg     4560

gtaatggggc gtgttttctt gccaaaggcg gttccaccct cgtgattgta tagggctctt     4620

ctcctgtatg aactctgaga tcagtgagct ctgatctcca agggaaagtt ttcctgcatt     4680

tgctgttttc tcatgtctct cccagtgtga attctttggt gtgcagtgcg ctctggcttc     4740

tagctgaaaa cttttccaca gttttacatt catgtggttt tctccactgt gaactctgtg     4800

attcagaatc agaagcagtt cttagtagag gcatttctac actgattgca ctgaggattt     4860

ctccccagtg tgaagtttct ggcatagagt cctggcttcc cgcagacgac tttcacactc     4920

tgccatgttc atgcctgtgg gcctctctgg caggaactct gatgcaccgc gaggcccatg     4980

tactcctgtg gctttctcac attcggtcta cttgcagggt atctccacag catgcaccat     5040

tctgggtaca gggggacatc ctctgttact gaagatgttg tcatatttag taccttcaca     5100

aggtttctct ccttccagaa ttttctgatg tacacaaata actgacttcc acaagagggc     5160

ttttccacac tcggtgtgtg catacagttt ctgcctgtga tcatttcttt atgttattat     5220

tttatttttt cgagataggg tcttgctcaa tttcttaggc tggagtgcag tggcacgatc     5280

atagctcact gaagtttcga cctgggctca agcaatcctc ccgcttcagc ctcctgagta     5340

gctggtgcgc acgaccatac ccagctaatg ttttattttt tgtagagacg aggtctcact     5400

atgttgccca ggctggtctc gaacttctga gctcgagcga tcctcctgcc tccacctccc     5460

aaagtgttcg gattacaaac gtgagccatc gcacctagcc tctttgatca tttctgtggt     5520

gttcagtgga ggttgacagc tccctaaaga ttttcctgtt tttttgcatg catgggtttg     5580

aattctttga ggtccaattt atttggaccc ctgaataaag ttttgtgggt tttcttctat     5640

gtgtggaatt tataaggcat tcttccagtg tggtttctct tatgtcgagt gagagctgac     5700

ctgcaccgaa ggttttgtcc catttgttgc ccttgaatta tttgtatgaa ttatatgttc     5760

cagtgaaaat ggagttctgg gttggaggct tattccatgt ttacacaatt aaaattgcag     5820

tgttcctctc tgggatgaga gctctaaagc agagtaagat tacgttctga tgtaagcttt     5880

aaccacctat ttataaggtc tcacctgtgg tccactgtgt tgagacttct acagaagagc     5940

ttctgtatag taaccatttt cttaggctgt ctcacttgtg tgaatcttct gacacattta     6000

ttatagcttt gtcccatttc ttatcctttt tgctctttag aaatttccct ttaatttatt     6060

acattcattg cttactgtaa agagtccagg taactgactt tattcagtta cttcctgttc     6120

aataaattta acttttccca aaa                                             6143


<210>  31
<211>  877
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Arg Pro Arg Arg Ala Arg Glu Pro Leu Leu Val Ala Leu Leu 
1               5                   10                  15      


Pro Leu Ala Trp Leu Ala Gln Ala Gly Leu Ala Arg Ala Ala Gly Ser 
            20                  25                  30          


Val Arg Leu Ala Gly Gly Leu Thr Leu Gly Gly Leu Phe Pro Val His 
        35                  40                  45              


Ala Arg Gly Ala Ala Gly Arg Ala Cys Gly Gln Leu Lys Lys Glu Gln 
    50                  55                  60                  


Gly Val His Arg Leu Glu Ala Met Leu Tyr Ala Leu Asp Arg Val Asn 
65                  70                  75                  80  


Ala Asp Pro Glu Leu Leu Pro Gly Val Arg Leu Gly Ala Arg Leu Leu 
                85                  90                  95      


Asp Thr Cys Ser Arg Asp Thr Tyr Ala Leu Glu Gln Ala Leu Ser Phe 
            100                 105                 110         


Val Gln Ala Leu Ile Arg Gly Arg Gly Asp Gly Asp Glu Val Gly Val 
        115                 120                 125             


Arg Cys Pro Gly Gly Val Pro Pro Leu Arg Pro Ala Pro Pro Glu Arg 
    130                 135                 140                 


Val Val Ala Val Val Gly Ala Ser Ala Ser Ser Val Ser Ile Met Val 
145                 150                 155                 160 


Ala Asn Val Leu Arg Leu Phe Ala Ile Pro Gln Ile Ser Tyr Ala Ser 
                165                 170                 175     


Thr Ala Pro Glu Leu Ser Asp Ser Thr Arg Tyr Asp Phe Phe Ser Arg 
            180                 185                 190         


Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala Met Val Asp Ile Val 
        195                 200                 205             


Arg Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu Ala Ser Glu Gly Asn 
    210                 215                 220                 


Tyr Gly Glu Ser Gly Val Glu Ala Phe Val Gln Ile Ser Arg Glu Ala 
225                 230                 235                 240 


Gly Gly Val Cys Ile Ala Gln Ser Ile Lys Ile Pro Arg Glu Pro Lys 
                245                 250                 255     


Pro Gly Glu Phe Ser Lys Val Ile Arg Arg Leu Met Glu Thr Pro Asn 
            260                 265                 270         


Ala Arg Gly Ile Ile Ile Phe Ala Asn Glu Asp Asp Ile Arg Arg Val 
        275                 280                 285             


Leu Glu Ala Ala Arg Gln Ala Asn Leu Thr Gly His Phe Leu Trp Val 
    290                 295                 300                 


Gly Ser Asp Ser Trp Gly Ala Lys Thr Ser Pro Ile Leu Ser Leu Glu 
305                 310                 315                 320 


Asp Val Ala Val Gly Ala Ile Thr Ile Leu Pro Lys Arg Ala Ser Ile 
                325                 330                 335     


Asp Gly Phe Asp Gln Tyr Phe Met Thr Arg Ser Leu Glu Asn Asn Arg 
            340                 345                 350         


Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Glu Asn Phe Asn Cys Lys 
        355                 360                 365             


Leu Thr Ser Ser Gly Thr Gln Ser Asp Asp Ser Thr Arg Lys Cys Thr 
    370                 375                 380                 


Gly Glu Glu Arg Ile Gly Arg Asp Ser Thr Tyr Glu Gln Glu Gly Lys 
385                 390                 395                 400 


Val Gln Phe Val Ile Asp Ala Val Tyr Ala Ile Ala His Ala Leu His 
                405                 410                 415     


Ser Met His Gln Ala Leu Cys Pro Gly His Thr Gly Leu Cys Pro Ala 
            420                 425                 430         


Met Glu Pro Thr Asp Gly Arg Met Leu Leu Gln Tyr Ile Arg Ala Val 
        435                 440                 445             


Arg Phe Asn Gly Ser Ala Gly Thr Pro Val Met Phe Asn Glu Asn Gly 
    450                 455                 460                 


Asp Ala Pro Gly Arg Tyr Asp Ile Phe Gln Tyr Gln Ala Thr Asn Gly 
465                 470                 475                 480 


Ser Ala Ser Ser Gly Gly Tyr Gln Ala Val Gly Gln Trp Ala Glu Thr 
                485                 490                 495     


Leu Arg Leu Asp Val Glu Ala Leu Gln Trp Ser Gly Asp Pro His Glu 
            500                 505                 510         


Val Pro Ser Ser Leu Cys Ser Leu Pro Cys Gly Pro Gly Glu Arg Lys 
        515                 520                 525             


Lys Met Val Lys Gly Val Pro Cys Cys Trp His Cys Glu Ala Cys Asp 
    530                 535                 540                 


Gly Tyr Arg Phe Gln Val Asp Glu Phe Thr Cys Glu Ala Cys Pro Gly 
545                 550                 555                 560 


Asp Met Arg Pro Thr Pro Asn His Thr Gly Cys Arg Pro Thr Pro Val 
                565                 570                 575     


Val Arg Leu Ser Trp Ser Ser Pro Trp Ala Ala Pro Pro Leu Leu Leu 
            580                 585                 590         


Ala Val Leu Gly Ile Val Ala Thr Thr Thr Val Val Ala Thr Phe Val 
        595                 600                 605             


Arg Tyr Asn Asn Thr Pro Ile Val Arg Ala Ser Gly Arg Glu Leu Ser 
    610                 615                 620                 


Tyr Val Leu Leu Thr Gly Ile Phe Leu Ile Tyr Ala Ile Thr Phe Leu 
625                 630                 635                 640 


Met Val Ala Glu Pro Gly Ala Ala Val Cys Ala Ala Arg Arg Leu Phe 
                645                 650                 655     


Leu Gly Leu Gly Thr Thr Leu Ser Tyr Ser Ala Leu Leu Thr Lys Thr 
            660                 665                 670         


Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val Thr Pro 
        675                 680                 685             


Pro Pro Phe Ile Ser Pro Thr Ser Gln Leu Val Ile Thr Phe Ser Leu 
    690                 695                 700                 


Thr Ser Leu Gln Val Val Gly Met Ile Ala Trp Leu Gly Ala Arg Pro 
705                 710                 715                 720 


Pro His Ser Val Ile Asp Tyr Glu Glu Gln Arg Thr Val Asp Pro Glu 
                725                 730                 735     


Gln Ala Arg Gly Val Leu Lys Cys Asp Met Ser Asp Leu Ser Leu Ile 
            740                 745                 750         


Gly Cys Leu Gly Tyr Ser Leu Leu Leu Met Val Thr Cys Thr Val Tyr 
        755                 760                 765             


Ala Ile Lys Ala Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro 
    770                 775                 780                 


Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Val 
785                 790                 795                 800 


Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu Lys Ile Tyr Ile Gln 
                805                 810                 815     


Thr Thr Thr Leu Thr Val Ser Leu Ser Leu Ser Ala Ser Val Ser Leu 
            820                 825                 830         


Gly Met Leu Tyr Val Pro Lys Thr Tyr Val Ile Leu Phe His Pro Glu 
        835                 840                 845             


Gln Asn Val Gln Lys Arg Lys Arg Ser Leu Lys Ala Thr Ser Thr Val 
    850                 855                 860                 


Ala Ala Pro Pro Lys Gly Glu Asp Ala Glu Ala His Lys 
865                 870                 875         


<210>  32
<211>  4149
<212>  DNA
<213>  Homo sapiens

<400>  32
agtgctgggc tgttggagag agcgagcagc aagccggtga gcgcgagcgc ggcgcgccgg       60

ccggctaacc cgagagcgcg aggcgcccca ggctggcagg cgccgcggga cccctcaccc      120

tctctggtcg cccctccccg gattccccca ccctccgtgc ctgcaggagc ccctgggctt      180

tcccggagga gctcgccctg aagggcccgg acctcggcga gcccaccacc gttccctcca      240

gcgccgccgc cgccaccgca gcagccggag cagcatggtc cagctgagga agctgctccg      300

cgtcctgact ttgatgaagt tcccctgctg cgtgctggag gtgctcctgt gcgcgctggc      360

ggcggcggcg cgcggccagg agatgtacgc cccgcactca atccggatcg agggggacgt      420

caccctcggg gggctgttcc ccgtgcacgc caagggtccc agcggagtgc cctgcggcga      480

catcaagagg gaaaacggga tccacaggct ggaagcgatg ctctacgccc tggaccagat      540

caacagtgat cccaacctac tgcccaacgt gacgctgggc gcgcggatcc tggacacttg      600

ttccagggac acttacgcgc tcgaacagtc gcttactttc gtccaggcgc tcatccagaa      660

ggacacctcc gacgtgcgct gcaccaacgg cgaaccgccg gttttcgtca agccggagaa      720

agtagttgga gtgattgggg cttcggggag ttcggtctcc atcatggtag ccaacatcct      780

gaggctcttc cagatccccc agattagtta tgcatcaacg gcacccgagc taagtgatga      840

ccggcgctat gacttcttct ctcgcgtggt gccacccgat tccttccaag cccaggccat      900

ggtagacatt gtaaaggccc taggctggaa ttatgtgtct accctcgcat cggaaggaag      960

ttatggagag aaaggtgtgg agtccttcac gcagatttcc aaagaggcag gtggactctg     1020

cattgcccag tccgtgagaa tcccccagga acgcaaagac aggaccattg actttgatag     1080

aattatcaaa cagctcctgg acacccccaa ctccagggcc gtcgtgattt ttgccaacga     1140

tgaggatata aagcagatcc ttgcagcagc caaaagagct gaccaagttg gccattttct     1200

ttgggtggga tcagacagct ggggatccaa aataaaccca ctgcaccagc atgaagatat     1260

cgcagaaggg gccatcacca ttcagcccaa gcgagccacg gtggaagggt ttgatgccta     1320

ctttacgtcc cgtacacttg aaaacaacag aagaaatgta tggtttgccg aatactggga     1380

ggaaaacttc aactgcaagt tgacgattag tgggtcaaaa aaagaagaca cagatcgcaa     1440

atgcacagga caggagagaa ttggaaaaga ttccaactat gagcaggagg gtaaagtcca     1500

gttcgtgatt gacgcagtct atgctatggc tcacgccctt caccacatga acaaggatct     1560

ctgtgctgac taccggggtg tctgcccaga gatggagcaa gctggaggca agaagttgct     1620

gaagtatata cgcaatgtta atttcaatgg tagtgctggc actccagtga tgtttaacaa     1680

gaacggggat gcacctgggc gttatgacat ctttcagtac cagaccacaa acaccagcaa     1740

cccgggttac cgtctgatcg ggcagtggac agacgaactt cagctcaata tagaagacat     1800

gcagtggggt aaaggagtcc gagagatacc cgcctcagtg tgcacactac catgtaagcc     1860

aggacagaga aagaagacac agaaaggaac tccttgctgt tggacctgtg agccttgcga     1920

tggttaccag taccagtttg atgagatgac atgccagcat tgcccctatg accagaggcc     1980

caatgaaaat cgaaccggat gccaggatat tcccatcatc aaactggagt ggcactcccc     2040

ctgggctgtg attcctgtct tcctggcaat gttggggatc attgccacca tctttgtcat     2100

ggccactttc atccgctaca atgacacgcc cattgtccgg gcatctgggc gggaactcag     2160

ctatgttctt ttgacgggca tctttctttg ctacatcatc actttcctga tgattgccaa     2220

accagatgtg gcagtgtgtt ctttccggcg agttttcttg ggcttgggta tgtgcatcag     2280

ttatgcagcc ctcttgacga aaacaaatcg gatttatcgc atatttgagc agggcaagaa     2340

atcagtaaca gctcccagac tcataagccc aacatcacaa ctggcaatca cttccagttt     2400

aatatcagtt cagcttctag gggtgttcat ttggtttggt gttgatccac ccaacatcat     2460

catagactat gatgaacaca agacaatgaa ccctgagcaa gccagagggg ttctcaagtg     2520

tgacattaca gatctccaaa tcatttgctc cttgggatat agcattcttc tcatggtcac     2580

atgtactgtg tatgccatca agactcgggg tgtacccgag aattttaacg aagccaagcc     2640

cattggattc actatgtaca cgacatgtat agtatggctt gccttcattc caattttttt     2700

tggcaccgct caatcagcgg aaaagctcta catacaaact accacgctta caatctccat     2760

gaacctaagt gcatcagtgg cgctggggat gctatacatg ccgaaagtgt acatcatcat     2820

tttccaccct gaactcaatg tccagaaacg gaagcgaagc ttcaaggcgg tagtcacagc     2880

agccaccatg tcatcgaggc tgtcacacaa acccagtgac agacccaacg gtgaggcaaa     2940

gaccgagctc tgtgaaaacg tagacccaaa cagccctgct gcaaaaaaga agtatgtcag     3000

ttataataac ctggttatct aacctgttcc attccatgga accatggagg aggaagaccc     3060

tcagttattt tgtcacccaa cctggcatag gactctttgg tcctacccgc ttcccatcac     3120

cggaggagct tccccggccg ggagaccagt gttagaggat ccaagcgacc taaacagctg     3180

ctttatgaaa tatccttact ttatctgggc ttaataagtc actgacatca gcactgccaa     3240

ctcggctgca attgtggacc ttccctacca aagggagtgt tgaaactcaa gtcccgccct     3300

ggctctttag aatggaccac tgagagccac aggaccgttt tggggctgac ctgtcttatt     3360

acgtatgtac ttctaggttg caaggttttg aaattttctg tacagtttgt gaggaccttt     3420

gcactttgcc atctgatgtc gtacctcggt tcactgtttg ttttcgaatg ccttgttttc     3480

atagagccct attctctcag acggtggaat atttggaaaa attttaaaac aattaaaatt     3540

ttaaagcaat cttggcagac taaaacaagt acatctgtac atgactgtat aattacgatt     3600

atagtaccac tgcacatcat gttttttttt ttaagacaaa aaagatgttt aaagaccaaa     3660

aactgtgctg agaaagtatg ccccacctat ctttggtata tgataggtta cataaaagga     3720

aggtattggc tgaactgaat agaggtcttg atctttggaa tgcatgccag taatgtattt     3780

tacagtacat gtttattatg ttcaatattt gtatttgtgt tctcttttgt tatttttaat     3840

tagggtatat gaatattttg caataatttt aataattatt aagctgtttg aaggaaagaa     3900

tatggatttt tcatgtcttg aggttttgtt catgccccct ttgactgatc agtgtgataa     3960

ggactttagg aaaaaaagca tgtatgtttt ttactgtttg taataagtac tttcgttaat     4020

cttgctgctt atgtgccaat ttagtggaaa aaaacaaccc ttgctgaaaa attccctctt     4080

tccattctct ttcaattctg tgatattgtc caagaatgta tcaataaaat actttggtta     4140

actttttta                                                             4149


<210>  33
<211>  915
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Val Gln Leu Arg Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe 
1               5                   10                  15      


Pro Cys Cys Val Leu Glu Val Leu Leu Cys Ala Leu Ala Ala Ala Ala 
            20                  25                  30          


Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp 
        35                  40                  45              


Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly 
    50                  55                  60                  


Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu 
                85                  90                  95      


Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln 
        115                 120                 125             


Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe 
    130                 135                 140                 


Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln 
225                 230                 235                 240 


Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile 
                245                 250                 255     


Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys 
            260                 265                 270         


Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn 
        275                 280                 285             


Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln 
    290                 295                 300                 


Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile 
305                 310                 315                 320 


Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile 
                325                 330                 335     


Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser 
            340                 345                 350         


Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp 
        355                 360                 365             


Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu 
    370                 375                 380                 


Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser 
385                 390                 395                 400 


Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr 
                405                 410                 415     


Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp 
            420                 425                 430         


Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu 
        435                 440                 445             


Leu Lys Tyr Ile Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro 
    450                 455                 460                 


Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe 
465                 470                 475                 480 


Gln Tyr Gln Thr Thr Asn Thr Ser Asn Pro Gly Tyr Arg Leu Ile Gly 
                485                 490                 495     


Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly 
            500                 505                 510         


Lys Gly Val Arg Glu Ile Pro Ala Ser Val Cys Thr Leu Pro Cys Lys 
        515                 520                 525             


Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr 
    530                 535                 540                 


Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys 
545                 550                 555                 560 


Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys 
                565                 570                 575     


Gln Asp Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val 
            580                 585                 590         


Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val 
        595                 600                 605             


Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser 
    610                 615                 620                 


Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr 
625                 630                 635                 640 


Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser 
                645                 650                 655     


Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala 
            660                 665                 670         


Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys 
        675                 680                 685             


Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala 
    690                 695                 700                 


Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp 
705                 710                 715                 720 


Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys 
                725                 730                 735     


Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr 
            740                 745                 750         


Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val 
        755                 760                 765             


Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe 
    770                 775                 780                 


Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val 
785                 790                 795                 800 


Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu 
                805                 810                 815     


Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser 
            820                 825                 830         


Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile 
        835                 840                 845             


Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys 
    850                 855                 860                 


Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro 
865                 870                 875                 880 


Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val 
                885                 890                 895     


Asp Pro Asn Ser Pro Ala Ala Lys Lys Lys Tyr Val Ser Tyr Asn Asn 
            900                 905                 910         


Leu Val Ile 
        915 


<210>  34
<211>  4241
<212>  DNA
<213>  Homo sapiens

<400>  34
agtgctgggc tgttggagag agcgagcagc aagccggtga gcgcgagcgc ggcgcgccgg       60

ccggctaacc cgagagcgcg aggcgcccca ggctggcagg cgccgcggga cccctcaccc      120

tctctggtcg cccctccccg gattccccca ccctccgtgc ctgcaggagc ccctgggctt      180

tcccggagga gctcgccctg aagggcccgg acctcggcga gcccaccacc gttccctcca      240

gcgccgccgc cgccaccgca gcagccggag cagcatggtc cagctgagga agctgctccg      300

cgtcctgact ttgatgaagt tcccctgctg cgtgctggag gtgctcctgt gcgcgctggc      360

ggcggcggcg cgcggccagg agatgtacgc cccgcactca atccggatcg agggggacgt      420

caccctcggg gggctgttcc ccgtgcacgc caagggtccc agcggagtgc cctgcggcga      480

catcaagagg gaaaacggga tccacaggct ggaagcgatg ctctacgccc tggaccagat      540

caacagtgat cccaacctac tgcccaacgt gacgctgggc gcgcggatcc tggacacttg      600

ttccagggac acttacgcgc tcgaacagtc gcttactttc gtccaggcgc tcatccagaa      660

ggacacctcc gacgtgcgct gcaccaacgg cgaaccgccg gttttcgtca agccggagaa      720

agtagttgga gtgattgggg cttcggggag ttcggtctcc atcatggtag ccaacatcct      780

gaggctcttc cagatccccc agattagtta tgcatcaacg gcacccgagc taagtgatga      840

ccggcgctat gacttcttct ctcgcgtggt gccacccgat tccttccaag cccaggccat      900

ggtagacatt gtaaaggccc taggctggaa ttatgtgtct accctcgcat cggaaggaag      960

ttatggagag aaaggtgtgg agtccttcac gcagatttcc aaagaggcag gtggactctg     1020

cattgcccag tccgtgagaa tcccccagga acgcaaagac aggaccattg actttgatag     1080

aattatcaaa cagctcctgg acacccccaa ctccagggcc gtcgtgattt ttgccaacga     1140

tgaggatata aagcagatcc ttgcagcagc caaaagagct gaccaagttg gccattttct     1200

ttgggtggga tcagacagct ggggatccaa aataaaccca ctgcaccagc atgaagatat     1260

cgcagaaggg gccatcacca ttcagcccaa gcgagccacg gtggaagggt ttgatgccta     1320

ctttacgtcc cgtacacttg aaaacaacag aagaaatgta tggtttgccg aatactggga     1380

ggaaaacttc aactgcaagt tgacgattag tgggtcaaaa aaagaagaca cagatcgcaa     1440

atgcacagga caggagagaa ttggaaaaga ttccaactat gagcaggagg gtaaagtcca     1500

gttcgtgatt gacgcagtct atgctatggc tcacgccctt caccacatga acaaggatct     1560

ctgtgctgac taccggggtg tctgcccaga gatggagcaa gctggaggca agaagttgct     1620

gaagtatata cgcaatgtta atttcaatgg tagtgctggc actccagtga tgtttaacaa     1680

gaacggggat gcacctgggc gttatgacat ctttcagtac cagaccacaa acaccagcaa     1740

cccgggttac cgtctgatcg ggcagtggac agacgaactt cagctcaata tagaagacat     1800

gcagtggggt aaaggagtcc gagagatacc cgcctcagtg tgcacactac catgtaagcc     1860

aggacagaga aagaagacac agaaaggaac tccttgctgt tggacctgtg agccttgcga     1920

tggttaccag taccagtttg atgagatgac atgccagcat tgcccctatg accagaggcc     1980

caatgaaaat cgaaccggat gccaggatat tcccatcatc aaactggagt ggcactcccc     2040

ctgggctgtg attcctgtct tcctggcaat gttggggatc attgccacca tctttgtcat     2100

ggccactttc atccgctaca atgacacgcc cattgtccgg gcatctgggc gggaactcag     2160

ctatgttctt ttgacgggca tctttctttg ctacatcatc actttcctga tgattgccaa     2220

accagatgtg gcagtgtgtt ctttccggcg agttttcttg ggcttgggta tgtgcatcag     2280

ttatgcagcc ctcttgacga aaacaaatcg gatttatcgc atatttgagc agggcaagaa     2340

atcagtaaca gctcccagac tcataagccc aacatcacaa ctggcaatca cttccagttt     2400

aatatcagtt cagcttctag gggtgttcat ttggtttggt gttgatccac ccaacatcat     2460

catagactat gatgaacaca agacaatgaa ccctgagcaa gccagagggg ttctcaagtg     2520

tgacattaca gatctccaaa tcatttgctc cttgggatat agcattcttc tcatggtcac     2580

atgtactgtg tatgccatca agactcgggg tgtacccgag aattttaacg aagccaagcc     2640

cattggattc actatgtaca cgacatgtat agtatggctt gccttcattc caattttttt     2700

tggcaccgct caatcagcgg aaaagctcta catacaaact accacgctta caatctccat     2760

gaacctaagt gcatcagtgg cgctggggat gctatacatg ccgaaagtgt acatcatcat     2820

tttccaccct gaactcaatg tccagaaacg gaagcgaagc ttcaaggcgg tagtcacagc     2880

agccaccatg tcatcgaggc tgtcacacaa acccagtgac agacccaacg gtgaggcaaa     2940

gaccgagctc tgtgaaaacg tagacccaaa caactgtata ccaccagtaa gaaagagtgt     3000

acaaaagtct gttacttggt acactatccc accaacagta tagcttttga ctgctttccc     3060

aaaggccctg ctgcaaaaaa gaagtatgtc agttataata acctggttat ctaacctgtt     3120

ccattccatg gaaccatgga ggaggaagac cctcagttat tttgtcaccc aacctggcat     3180

aggactcttt ggtcctaccc gcttcccatc accggaggag cttccccggc cgggagacca     3240

gtgttagagg atccaagcga cctaaacagc tgctttatga aatatcctta ctttatctgg     3300

gcttaataag tcactgacat cagcactgcc aactcggctg caattgtgga ccttccctac     3360

caaagggagt gttgaaactc aagtcccgcc ctggctcttt agaatggacc actgagagcc     3420

acaggaccgt tttggggctg acctgtctta ttacgtatgt acttctaggt tgcaaggttt     3480

tgaaattttc tgtacagttt gtgaggacct ttgcactttg ccatctgatg tcgtacctcg     3540

gttcactgtt tgttttcgaa tgccttgttt tcatagagcc ctattctctc agacggtgga     3600

atatttggaa aaattttaaa acaattaaaa ttttaaagca atcttggcag actaaaacaa     3660

gtacatctgt acatgactgt ataattacga ttatagtacc actgcacatc atgttttttt     3720

ttttaagaca aaaaagatgt ttaaagacca aaaactgtgc tgagaaagta tgccccacct     3780

atctttggta tatgataggt tacataaaag gaaggtattg gctgaactga atagaggtct     3840

tgatctttgg aatgcatgcc agtaatgtat tttacagtac atgtttatta tgttcaatat     3900

ttgtatttgt gttctctttt gttattttta attagggtat atgaatattt tgcaataatt     3960

ttaataatta ttaagctgtt tgaaggaaag aatatggatt tttcatgtct tgaggttttg     4020

ttcatgcccc ctttgactga tcagtgtgat aaggacttta ggaaaaaaag catgtatgtt     4080

ttttactgtt tgtaataagt actttcgtta atcttgctgc ttatgtgcca atttagtgga     4140

aaaaaacaac ccttgctgaa aaattccctc tttccattct ctttcaattc tgtgatattg     4200

tccaagaatg tatcaataaa atactttggt taactttttt a                         4241


<210>  35
<211>  922
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Val Gln Leu Arg Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe 
1               5                   10                  15      


Pro Cys Cys Val Leu Glu Val Leu Leu Cys Ala Leu Ala Ala Ala Ala 
            20                  25                  30          


Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp 
        35                  40                  45              


Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly 
    50                  55                  60                  


Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu 
                85                  90                  95      


Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln 
        115                 120                 125             


Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe 
    130                 135                 140                 


Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln 
225                 230                 235                 240 


Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile 
                245                 250                 255     


Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys 
            260                 265                 270         


Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn 
        275                 280                 285             


Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln 
    290                 295                 300                 


Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile 
305                 310                 315                 320 


Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile 
                325                 330                 335     


Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser 
            340                 345                 350         


Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp 
        355                 360                 365             


Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu 
    370                 375                 380                 


Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser 
385                 390                 395                 400 


Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr 
                405                 410                 415     


Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp 
            420                 425                 430         


Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu 
        435                 440                 445             


Leu Lys Tyr Ile Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro 
    450                 455                 460                 


Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe 
465                 470                 475                 480 


Gln Tyr Gln Thr Thr Asn Thr Ser Asn Pro Gly Tyr Arg Leu Ile Gly 
                485                 490                 495     


Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly 
            500                 505                 510         


Lys Gly Val Arg Glu Ile Pro Ala Ser Val Cys Thr Leu Pro Cys Lys 
        515                 520                 525             


Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr 
    530                 535                 540                 


Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys 
545                 550                 555                 560 


Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys 
                565                 570                 575     


Gln Asp Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val 
            580                 585                 590         


Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val 
        595                 600                 605             


Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser 
    610                 615                 620                 


Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr 
625                 630                 635                 640 


Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser 
                645                 650                 655     


Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala 
            660                 665                 670         


Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys 
        675                 680                 685             


Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala 
    690                 695                 700                 


Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp 
705                 710                 715                 720 


Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys 
                725                 730                 735     


Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr 
            740                 745                 750         


Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val 
        755                 760                 765             


Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe 
    770                 775                 780                 


Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val 
785                 790                 795                 800 


Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu 
                805                 810                 815     


Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser 
            820                 825                 830         


Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile 
        835                 840                 845             


Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys 
    850                 855                 860                 


Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro 
865                 870                 875                 880 


Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val 
                885                 890                 895     


Asp Pro Asn Asn Cys Ile Pro Pro Val Arg Lys Ser Val Gln Lys Ser 
            900                 905                 910         


Val Thr Trp Tyr Thr Ile Pro Pro Thr Val 
        915                 920         


<210>  36

<400>  36
000

<210>  37
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Val Gln Leu Arg Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe 
1               5                   10                  15      


Pro Cys Cys Val Leu Glu Val Leu Leu Cys Ala Leu Ala Ala Ala Ala 
            20                  25                  30          


Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp 
        35                  40                  45              


Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly 
    50                  55                  60                  


Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu 
                85                  90                  95      


Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln 
        115                 120                 125             


Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe 
    130                 135                 140                 


Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln 
225                 230                 235                 240 


Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile 
                245                 250                 255     


Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys 
            260                 265                 270         


Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn 
        275                 280                 285             


Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln 
    290                 295                 300                 


Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile 
305                 310                 315                 320 


Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile 
                325                 330                 335     


Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser 
            340                 345                 350         


Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp 
        355                 360                 365             


Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu 
    370                 375                 380                 


Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser 
385                 390                 395                 400 


Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr 
                405                 410                 415     


Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp 
            420                 425                 430         


Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu 
        435                 440                 445             


Leu Lys Tyr Ile Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro 
    450                 455                 460                 


Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe 
465                 470                 475                 480 


Gln Tyr Gln Thr Thr Asn Thr Ser Asn Pro Gly Tyr Arg Leu Ile Gly 
                485                 490                 495     


Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly 
            500                 505                 510         


Lys Gly Val Arg Glu Ile Pro Ala Ser Val Cys Thr Leu Pro Cys Lys 
        515                 520                 525             


Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr 
    530                 535                 540                 


Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys 
545                 550                 555                 560 


Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys 
                565                 570                 575     


Gln Asp Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val 
            580                 585                 590         


Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val 
        595                 600                 605             


Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser 
    610                 615                 620                 


Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr 
625                 630                 635                 640 


Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser 
                645                 650                 655     


Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala 
            660                 665                 670         


Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys 
        675                 680                 685             


Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala 
    690                 695                 700                 


Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp 
705                 710                 715                 720 


Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys 
                725                 730                 735     


Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr 
            740                 745                 750         


Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val 
        755                 760                 765             


Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe 
    770                 775                 780                 


Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val 
785                 790                 795                 800 


Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu 
                805                 810                 815     


Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser 
            820                 825                 830         


Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile 
        835                 840                 845             


Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys 
    850                 855                 860                 


Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro 
865                 870                 875                 880 


Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val 
                885                 890                 895     


Asp Pro Asn Asn Phe Phe Phe Trp Leu Tyr Ser Gly Thr Trp 
            900                 905                 910 


<210>  38

<400>  38
000

<210>  39
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Val Gln Leu Arg Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe 
1               5                   10                  15      


Pro Cys Cys Val Leu Glu Val Leu Leu Cys Ala Leu Ala Ala Ala Ala 
            20                  25                  30          


Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp 
        35                  40                  45              


Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly 
    50                  55                  60                  


Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu 
                85                  90                  95      


Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln 
        115                 120                 125             


Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe 
    130                 135                 140                 


Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln 
225                 230                 235                 240 


Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile 
                245                 250                 255     


Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys 
            260                 265                 270         


Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn 
        275                 280                 285             


Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln 
    290                 295                 300                 


Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile 
305                 310                 315                 320 


Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile 
                325                 330                 335     


Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser 
            340                 345                 350         


Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp 
        355                 360                 365             


Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu 
    370                 375                 380                 


Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser 
385                 390                 395                 400 


Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr 
                405                 410                 415     


Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp 
            420                 425                 430         


Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu 
        435                 440                 445             


Leu Lys Tyr Ile Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro 
    450                 455                 460                 


Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe 
465                 470                 475                 480 


Gln Tyr Gln Thr Thr Asn Thr Ser Asn Pro Gly Tyr Arg Leu Ile Gly 
                485                 490                 495     


Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly 
            500                 505                 510         


Lys Gly Val Arg Glu Ile Pro Ala Ser Val Cys Thr Leu Pro Cys Lys 
        515                 520                 525             


Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr 
    530                 535                 540                 


Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys 
545                 550                 555                 560 


Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys 
                565                 570                 575     


Gln Asp Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val 
            580                 585                 590         


Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val 
        595                 600                 605             


Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser 
    610                 615                 620                 


Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr 
625                 630                 635                 640 


Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser 
                645                 650                 655     


Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala 
            660                 665                 670         


Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys 
        675                 680                 685             


Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala 
    690                 695                 700                 


Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp 
705                 710                 715                 720 


Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys 
                725                 730                 735     


Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr 
            740                 745                 750         


Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val 
        755                 760                 765             


Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe 
    770                 775                 780                 


Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val 
785                 790                 795                 800 


Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu 
                805                 810                 815     


Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser 
            820                 825                 830         


Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile 
        835                 840                 845             


Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys 
    850                 855                 860                 


Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro 
865                 870                 875                 880 


Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val 
                885                 890                 895     


Asp Pro Asn Ile Thr Ser Glu Asp Leu Ser Leu His Lys Glu Asp 
            900                 905                 910     


<210>  40

<400>  40
000

<210>  41
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Val Gln Leu Arg Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe 
1               5                   10                  15      


Pro Cys Cys Val Leu Glu Val Leu Leu Cys Ala Leu Ala Ala Ala Ala 
            20                  25                  30          


Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp 
        35                  40                  45              


Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly 
    50                  55                  60                  


Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu 
                85                  90                  95      


Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln 
        115                 120                 125             


Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe 
    130                 135                 140                 


Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln 
225                 230                 235                 240 


Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile 
                245                 250                 255     


Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys 
            260                 265                 270         


Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn 
        275                 280                 285             


Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln 
    290                 295                 300                 


Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile 
305                 310                 315                 320 


Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile 
                325                 330                 335     


Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser 
            340                 345                 350         


Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp 
        355                 360                 365             


Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu 
    370                 375                 380                 


Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser 
385                 390                 395                 400 


Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr 
                405                 410                 415     


Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp 
            420                 425                 430         


Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu 
        435                 440                 445             


Leu Lys Tyr Ile Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro 
    450                 455                 460                 


Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe 
465                 470                 475                 480 


Gln Tyr Gln Thr Thr Asn Thr Ser Asn Pro Gly Tyr Arg Leu Ile Gly 
                485                 490                 495     


Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly 
            500                 505                 510         


Lys Gly Val Arg Glu Ile Pro Ala Ser Val Cys Thr Leu Pro Cys Lys 
        515                 520                 525             


Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr 
    530                 535                 540                 


Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys 
545                 550                 555                 560 


Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys 
                565                 570                 575     


Gln Asp Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val 
            580                 585                 590         


Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val 
        595                 600                 605             


Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser 
    610                 615                 620                 


Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr 
625                 630                 635                 640 


Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser 
                645                 650                 655     


Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala 
            660                 665                 670         


Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys 
        675                 680                 685             


Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala 
    690                 695                 700                 


Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp 
705                 710                 715                 720 


Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys 
                725                 730                 735     


Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr 
            740                 745                 750         


Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val 
        755                 760                 765             


Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe 
    770                 775                 780                 


Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val 
785                 790                 795                 800 


Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu 
                805                 810                 815     


Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser 
            820                 825                 830         


Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile 
        835                 840                 845             


Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys 
    850                 855                 860                 


Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro 
865                 870                 875                 880 


Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val 
                885                 890                 895     


Asp Pro Asn Ser Glu Lys Cys Asn Cys Tyr 
            900                 905     


<210>  42
<211>  3686
<212>  DNA
<213>  Homo sapiens

<400>  42
gcgctcggcg ctctgactgg gcgtgcggcg gcaggatttt aaagcgctct gcctcggatc       60

gtctgccctg ggtgacctcc cggacctgcc ctggtggaat ccggacttgc cccgccgaga      120

tgacgaggaa taattctgct acaaggctga tttcaaggac atgaattgtt gacctcatcc      180

caacatcaga acctcagatg ttctaatttt tgcaccattc caggcaagtt gatcttataa      240

ggaaataaaa ttgaacctta ggggtctgat ggaaattcac tgtgacattc aaatcaagaa      300

aacttgctaa tgcccacaga gccttttccc catgggccct gatggtagcc tccagaaggt      360

gcagcctcag gtggtgccct ttcttctgtg gcaagaataa actttgggtc ttggattgca      420

ataccacctg tggagaaaat ggtatgcgag ggaaagcgat cagcctcttg cccttgtttc      480

ttcctcttga ccgccaagtt ctactggatc ctcacaatga tgcaaagaac tcacagccag      540

gagtatgccc attccatacg ggtggatggg gacattattt tggggggtct cttccctgtc      600

cacgcaaagg gagagagagg ggtgccttgt ggggagctga agaaggaaaa ggggattcac      660

agactggagg ccatgcttta tgcaattgac cagattaaca aggaccctga tctcctttcc      720

aacatcactc tgggtgtccg catcctcgac acgtgctcta gggacaccta tgctttggag      780

cagtctctaa cattcgtgca ggcattaata gagaaagatg cttcggatgt gaagtgtgct      840

aatggagatc cacccatttt caccaagccc gacaagattt ctggcgtcat aggtgctgca      900

gcaagctccg tgtccatcat ggttgctaac attttaagac tttttaagat acctcaaatc      960

agctatgcat ccacagcccc agagctaagt gataacacca ggtatgactt tttctctcga     1020

gtggttccgc ctgactccta ccaagcccaa gccatggtgg acatcgtgac agcactggga     1080

tggaattatg tttcgacact ggcttctgag gggaactatg gtgagagcgg tgtggaggcc     1140

ttcacccaga tctcgaggga gattggtggt gtttgcattg ctcagtcaca gaaaatccca     1200

cgtgaaccaa gacctggaga atttgaaaaa attatcaaac gcctgctaga aacacctaat     1260

gctcgagcag tgattatgtt tgccaatgag gatgacatca ggaggatatt ggaagcagca     1320

aaaaaactaa accaaagtgg gcattttctc tggattggct cagatagttg gggatccaaa     1380

atagcacctg tctatcagca agaggagatt gcagaagggg ctgtgacaat tttgcccaaa     1440

cgagcatcaa ttgatggatt tgatcgatac tttagaagcc gaactcttgc caataatcga     1500

agaaatgtgt ggtttgcaga attctgggag gagaattttg gctgcaagtt aggatcacat     1560

gggaaaagga acagtcatat aaagaaatgc acagggctgg agcgaattgc tcgggattca     1620

tcttatgaac aggaaggaaa ggtccaattt gtaattgatg ctgtatattc catggcttac     1680

gccctgcaca atatgcacaa agatctctgc cctggataca ttggcctttg tccacgaatg     1740

agtaccattg atgggaaaga gctacttggt tatattcggg ctgtaaattt taatggcagt     1800

gctggcactc ctgtcacttt taatgaaaac ggagatgctc ctggacgtta tgatatcttc     1860

cagtatcaaa taaccaacaa aagcacagag tacaaagtca tcggccactg gaccaatcag     1920

cttcatctaa aagtggaaga catgcagtgg gctcatagag aacatactca cccggcgtct     1980

gtctgcagcc tgccgtgtaa gccaggggag aggaagaaaa cggtgaaagg ggtcccttgc     2040

tgctggcact gtgaacgctg tgaaggttac aactaccagg tggatgagct gtcctgtgaa     2100

ctttgccctc tggatcagag acccaacatg aaccgcacag gctgccagct tatccccatc     2160

atcaaattgg agtggcattc tccctgggct gtggtgcctg tgtttgttgc aatattggga     2220

atcatcgcca ccacctttgt gatcgtgacc tttgtccgct ataatgacac acctatcgtg     2280

agggcttcag gacgcgaact tagttacgtg ctcctaacgg ggatttttct ctgttattca     2340

atcacgtttt taatgattgc agcaccagat acaatcatat gctccttccg acgggtcttc     2400

ctaggacttg gcatgtgttt cagctatgca gcccttctga ccaaaacaaa ccgtatccac     2460

cgaatatttg agcaggggaa gaaatctgtc acagcgccca agttcattag tccagcatct     2520

cagctggtga tcaccttcag cctcatctcc gtccagctcc ttggagtgtt tgtctggttt     2580

gttgtggatc ccccccacat catcattgac tatggagagc agcggacact agatccagag     2640

aaggccaggg gagtgctcaa gtgtgacatt tctgatctct cactcatttg ttcacttgga     2700

tacagtatcc tcttgatggt cacttgtact gtttatgcca ttaaaacgag aggtgtccca     2760

gagactttca atgaagccaa acctattgga tttaccatgt ataccacctg catcatttgg     2820

ttagctttca tccccatctt ttttggtaca gcccagtcag cagaaaagat gtacatccag     2880

acaacaacac ttactgtctc catgagttta agtgcttcag tatctctggg catgctctat     2940

atgcccaagg tttatattat aatttttcat ccagaacaga atgttcaaaa acgcaagagg     3000

agcttcaagg ctgtggtgac agctgccacc atgcaaagca aactgatcca aaaaggaaat     3060

gacagaccaa atggcgaggt gaaaagtgaa ctctgtgaga gtcttgaaac caacacttcc     3120

tctaccaaga caacatatat cagttacagc aatcattcaa tctgaaacag ggaaatggca     3180

caatctgaag agatgtggta tatgatctta aatgatgaac atgagaccgc aaaaattcac     3240

tcctggagat ctccgtagac tacaatcaat caaatcaata gtcagtcttg taaggaacaa     3300

aaattagcca tgagccaaaa gtatcaataa acggggagtg aagaaacccg ttttatacaa     3360

taaaaccaat gagtgtcaag ctaaagtatt gcttattcat gagcagttaa aacaaatcac     3420

aaaaggaaaa ctaatgttag ctcgtgaaaa aaaatgctgt tgaaataaat aatgtctgat     3480

gttattcttg tatttttctg tgattgtgag aactcccgtt cctgtcccac attgtttaac     3540

ttgtataaga caatgagtct gtttcttgta atggctgacc agattgaagc cctgggttgt     3600

gctaaaaata aatgcaatga ttgatgcatg caatttttta tacaaataat ttatttctaa     3660

taataaagga atgttttgca aatgtt                                          3686


<210>  43
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Val Cys Glu Gly Lys Arg Ser Ala Ser Cys Pro Cys Phe Phe Leu 
1               5                   10                  15      


Leu Thr Ala Lys Phe Tyr Trp Ile Leu Thr Met Met Gln Arg Thr His 
            20                  25                  30          


Ser Gln Glu Tyr Ala His Ser Ile Arg Val Asp Gly Asp Ile Ile Leu 
        35                  40                  45              


Gly Gly Leu Phe Pro Val His Ala Lys Gly Glu Arg Gly Val Pro Cys 
    50                  55                  60                  


Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu Ala Met Leu 
65                  70                  75                  80  


Tyr Ala Ile Asp Gln Ile Asn Lys Asp Pro Asp Leu Leu Ser Asn Ile 
                85                  90                  95      


Thr Leu Gly Val Arg Ile Leu Asp Thr Cys Ser Arg Asp Thr Tyr Ala 
            100                 105                 110         


Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu Lys Asp Ala 
        115                 120                 125             


Ser Asp Val Lys Cys Ala Asn Gly Asp Pro Pro Ile Phe Thr Lys Pro 
    130                 135                 140                 


Asp Lys Ile Ser Gly Val Ile Gly Ala Ala Ala Ser Ser Val Ser Ile 
145                 150                 155                 160 


Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln Ile Ser Tyr 
                165                 170                 175     


Ala Ser Thr Ala Pro Glu Leu Ser Asp Asn Thr Arg Tyr Asp Phe Phe 
            180                 185                 190         


Ser Arg Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala Met Val Asp 
        195                 200                 205             


Ile Val Thr Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu Ala Ser Glu 
    210                 215                 220                 


Gly Asn Tyr Gly Glu Ser Gly Val Glu Ala Phe Thr Gln Ile Ser Arg 
225                 230                 235                 240 


Glu Ile Gly Gly Val Cys Ile Ala Gln Ser Gln Lys Ile Pro Arg Glu 
                245                 250                 255     


Pro Arg Pro Gly Glu Phe Glu Lys Ile Ile Lys Arg Leu Leu Glu Thr 
            260                 265                 270         


Pro Asn Ala Arg Ala Val Ile Met Phe Ala Asn Glu Asp Asp Ile Arg 
        275                 280                 285             


Arg Ile Leu Glu Ala Ala Lys Lys Leu Asn Gln Ser Gly His Phe Leu 
    290                 295                 300                 


Trp Ile Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro Val Tyr Gln 
305                 310                 315                 320 


Gln Glu Glu Ile Ala Glu Gly Ala Val Thr Ile Leu Pro Lys Arg Ala 
                325                 330                 335     


Ser Ile Asp Gly Phe Asp Arg Tyr Phe Arg Ser Arg Thr Leu Ala Asn 
            340                 345                 350         


Asn Arg Arg Asn Val Trp Phe Ala Glu Phe Trp Glu Glu Asn Phe Gly 
        355                 360                 365             


Cys Lys Leu Gly Ser His Gly Lys Arg Asn Ser His Ile Lys Lys Cys 
    370                 375                 380                 


Thr Gly Leu Glu Arg Ile Ala Arg Asp Ser Ser Tyr Glu Gln Glu Gly 
385                 390                 395                 400 


Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ser Met Ala Tyr Ala Leu 
                405                 410                 415     


His Asn Met His Lys Asp Leu Cys Pro Gly Tyr Ile Gly Leu Cys Pro 
            420                 425                 430         


Arg Met Ser Thr Ile Asp Gly Lys Glu Leu Leu Gly Tyr Ile Arg Ala 
        435                 440                 445             


Val Asn Phe Asn Gly Ser Ala Gly Thr Pro Val Thr Phe Asn Glu Asn 
    450                 455                 460                 


Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe Gln Tyr Gln Ile Thr Asn 
465                 470                 475                 480 


Lys Ser Thr Glu Tyr Lys Val Ile Gly His Trp Thr Asn Gln Leu His 
                485                 490                 495     


Leu Lys Val Glu Asp Met Gln Trp Ala His Arg Glu His Thr His Pro 
            500                 505                 510         


Ala Ser Val Cys Ser Leu Pro Cys Lys Pro Gly Glu Arg Lys Lys Thr 
        515                 520                 525             


Val Lys Gly Val Pro Cys Cys Trp His Cys Glu Arg Cys Glu Gly Tyr 
    530                 535                 540                 


Asn Tyr Gln Val Asp Glu Leu Ser Cys Glu Leu Cys Pro Leu Asp Gln 
545                 550                 555                 560 


Arg Pro Asn Met Asn Arg Thr Gly Cys Gln Leu Ile Pro Ile Ile Lys 
                565                 570                 575     


Leu Glu Trp His Ser Pro Trp Ala Val Val Pro Val Phe Val Ala Ile 
            580                 585                 590         


Leu Gly Ile Ile Ala Thr Thr Phe Val Ile Val Thr Phe Val Arg Tyr 
        595                 600                 605             


Asn Asp Thr Pro Ile Val Arg Ala Ser Gly Arg Glu Leu Ser Tyr Val 
    610                 615                 620                 


Leu Leu Thr Gly Ile Phe Leu Cys Tyr Ser Ile Thr Phe Leu Met Ile 
625                 630                 635                 640 


Ala Ala Pro Asp Thr Ile Ile Cys Ser Phe Arg Arg Val Phe Leu Gly 
                645                 650                 655     


Leu Gly Met Cys Phe Ser Tyr Ala Ala Leu Leu Thr Lys Thr Asn Arg 
            660                 665                 670         


Ile His Arg Ile Phe Glu Gln Gly Lys Lys Ser Val Thr Ala Pro Lys 
        675                 680                 685             


Phe Ile Ser Pro Ala Ser Gln Leu Val Ile Thr Phe Ser Leu Ile Ser 
    690                 695                 700                 


Val Gln Leu Leu Gly Val Phe Val Trp Phe Val Val Asp Pro Pro His 
705                 710                 715                 720 


Ile Ile Ile Asp Tyr Gly Glu Gln Arg Thr Leu Asp Pro Glu Lys Ala 
                725                 730                 735     


Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser Leu Ile Cys Ser 
            740                 745                 750         


Leu Gly Tyr Ser Ile Leu Leu Met Val Thr Cys Thr Val Tyr Ala Ile 
        755                 760                 765             


Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro Ile Gly 
    770                 775                 780                 


Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Ile Pro Ile 
785                 790                 795                 800 


Phe Phe Gly Thr Ala Gln Ser Ala Glu Lys Met Tyr Ile Gln Thr Thr 
                805                 810                 815     


Thr Leu Thr Val Ser Met Ser Leu Ser Ala Ser Val Ser Leu Gly Met 
            820                 825                 830         


Leu Tyr Met Pro Lys Val Tyr Ile Ile Ile Phe His Pro Glu Gln Asn 
        835                 840                 845             


Val Gln Lys Arg Lys Arg Ser Phe Lys Ala Val Val Thr Ala Ala Thr 
    850                 855                 860                 


Met Gln Ser Lys Leu Ile Gln Lys Gly Asn Asp Arg Pro Asn Gly Glu 
865                 870                 875                 880 


Val Lys Ser Glu Leu Cys Glu Ser Leu Glu Thr Asn Thr Ser Ser Thr 
                885                 890                 895     


Lys Thr Thr Tyr Ile Ser Tyr Ser Asn His Ser Ile 
            900                 905             


<210>  44
<211>  3759
<212>  DNA
<213>  Homo sapiens

<400>  44
agctcagccc cctcagccca gagatcagcc acaagtgcgg ccgctgtgct cgcctcacgc       60

ggcggcggcg gcggcggcgg cggcgctgac atggagctgc gggcccccgg cgggcttcct      120

caccgcgccc tctgcgggga gcagggaata attctgctac aaggctgatt tcaaggacat      180

gaattgttga cctcatccca acatcagaac ctcagatgtt ctaatttttg caccattcca      240

ggcaagttga tcttataagg aaataaaatt gaaccttagg ggtctgatgg aaattcactg      300

tgacattcaa atcaagaaaa cttgctaatg cccacagagc cttttcccca tgggccctga      360

tggtagcctc cagaaggtgc agcctcaggt ggtgcccttt cttctgtggc aagaataaac      420

tttgggtctt ggattgcaat accacctgtg gagaaaatgg tatgcgaggg aaagcgatca      480

gcctcttgcc cttgtttctt cctcttgacc gccaagttct actggatcct cacaatgatg      540

caaagaactc acagccagga gtatgcccat tccatacggg tggatgggga cattattttg      600

gggggtctct tccctgtcca cgcaaaggga gagagagggg tgccttgtgg ggagctgaag      660

aaggaaaagg ggattcacag actggaggcc atgctttatg caattgacca gattaacaag      720

gaccctgatc tcctttccaa catcactctg ggtgtccgca tcctcgacac gtgctctagg      780

gacacctatg ctttggagca gtctctaaca ttcgtgcagg cattaataga gaaagatgct      840

tcggatgtga agtgtgctaa tggagatcca cccattttca ccaagcccga caagatttct      900

ggcgtcatag gtgctgcagc aagctccgtg tccatcatgg ttgctaacat tttaagactt      960

tttaagatac ctcaaatcag ctatgcatcc acagccccag agctaagtga taacaccagg     1020

tatgactttt tctctcgagt ggttccgcct gactcctacc aagcccaagc catggtggac     1080

atcgtgacag cactgggatg gaattatgtt tcgacactgg cttctgaggg gaactatggt     1140

gagagcggtg tggaggcctt cacccagatc tcgagggaga ttggtggtgt ttgcattgct     1200

cagtcacaga aaatcccacg tgaaccaaga cctggagaat ttgaaaaaat tatcaaacgc     1260

ctgctagaaa cacctaatgc tcgagcagtg attatgtttg ccaatgagga tgacatcagg     1320

aggatattgg aagcagcaaa aaaactaaac caaagtgggc attttctctg gattggctca     1380

gatagttggg gatccaaaat agcacctgtc tatcagcaag aggagattgc agaaggggct     1440

gtgacaattt tgcccaaacg agcatcaatt gatggatttg atcgatactt tagaagccga     1500

actcttgcca ataatcgaag aaatgtgtgg tttgcagaat tctgggagga gaattttggc     1560

tgcaagttag gatcacatgg gaaaaggaac agtcatataa agaaatgcac agggctggag     1620

cgaattgctc gggattcatc ttatgaacag gaaggaaagg tccaatttgt aattgatgct     1680

gtatattcca tggcttacgc cctgcacaat atgcacaaag atctctgccc tggatacatt     1740

ggcctttgtc cacgaatgag taccattgat gggaaagagc tacttggtta tattcgggct     1800

gtaaatttta atggcagtgc tggcactcct gtcactttta atgaaaacgg agatgctcct     1860

ggacgttatg atatcttcca gtatcaaata accaacaaaa gcacagagta caaagtcatc     1920

ggccactgga ccaatcagct tcatctaaaa gtggaagaca tgcagtgggc tcatagagaa     1980

catactcacc cggcgtctgt ctgcagcctg ccgtgtaagc caggggagag gaagaaaacg     2040

gtgaaagggg tcccttgctg ctggcactgt gaacgctgtg aaggttacaa ctaccaggtg     2100

gatgagctgt cctgtgaact ttgccctctg gatcagagac ccaacatgaa ccgcacaggc     2160

tgccagctta tccccatcat caaattggag tggcattctc cctgggctgt ggtgcctgtg     2220

tttgttgcaa tattgggaat catcgccacc acctttgtga tcgtgacctt tgtccgctat     2280

aatgacacac ctatcgtgag ggcttcagga cgcgaactta gttacgtgct cctaacgggg     2340

atttttctct gttattcaat cacgttttta atgattgcag caccagatac aatcatatgc     2400

tccttccgac gggtcttcct aggacttggc atgtgtttca gctatgcagc ccttctgacc     2460

aaaacaaacc gtatccaccg aatatttgag caggggaaga aatctgtcac agcgcccaag     2520

ttcattagtc cagcatctca gctggtgatc accttcagcc tcatctccgt ccagctcctt     2580

ggagtgtttg tctggtttgt tgtggatccc ccccacatca tcattgacta tggagagcag     2640

cggacactag atccagagaa ggccagggga gtgctcaagt gtgacatttc tgatctctca     2700

ctcatttgtt cacttggata cagtatcctc ttgatggtca cttgtactgt ttatgccatt     2760

aaaacgagag gtgtcccaga gactttcaat gaagccaaac ctattggatt taccatgtat     2820

accacctgca tcatttggtt agctttcatc cccatctttt ttggtacagc ccagtcagca     2880

gaaaagatgt acatccagac aacaacactt actgtctcca tgagtttaag tgcttcagta     2940

tctctgggca tgctctatat gcccaaggtt tatattataa tttttcatcc agaacagaat     3000

gttcaaaaac gcaagaggag cttcaaggct gtggtgacag ctgccaccat gcaaagcaaa     3060

ctgatccaaa aaggaaatga cagaccaaat ggcgaggtga aaagtgaact ctgtgagagt     3120

cttgaaacca acagtaagtc atctgtagag tttccgatgg tcaagagcgg gagcacttcc     3180

taatagatct tcctctacca agacaacata tatcagttac agcaatcatt caatctgaaa     3240

cagggaaatg gcacaatctg aagagatgtg gtatatgatc ttaaatgatg aacatgagac     3300

cgcaaaaatt cactcctgga gatctccgta gactacaatc aatcaaatca atagtcagtc     3360

ttgtaaggaa caaaaattag ccatgagcca aaagtatcaa taaacgggga gtgaagaaac     3420

ccgttttata caataaaacc aatgagtgtc aagctaaagt attgcttatt catgagcagt     3480

taaaacaaat cacaaaagga aaactaatgt tagctcgtga aaaaaaatgc tgttgaaata     3540

aataatgtct gatgttattc ttgtattttt ctgtgattgt gagaactccc gttcctgtcc     3600

cacattgttt aacttgtata agacaatgag tctgtttctt gtaatggctg accagattga     3660

agccctgggt tgtgctaaaa ataaatgcaa tgattgatgc atgcaatttt ttatacaaat     3720

aatttatttc taataataaa ggaatgtttt gcaaatgtt                            3759


<210>  45
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Val Cys Glu Gly Lys Arg Ser Ala Ser Cys Pro Cys Phe Phe Leu 
1               5                   10                  15      


Leu Thr Ala Lys Phe Tyr Trp Ile Leu Thr Met Met Gln Arg Thr His 
            20                  25                  30          


Ser Gln Glu Tyr Ala His Ser Ile Arg Val Asp Gly Asp Ile Ile Leu 
        35                  40                  45              


Gly Gly Leu Phe Pro Val His Ala Lys Gly Glu Arg Gly Val Pro Cys 
    50                  55                  60                  


Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu Ala Met Leu 
65                  70                  75                  80  


Tyr Ala Ile Asp Gln Ile Asn Lys Asp Pro Asp Leu Leu Ser Asn Ile 
                85                  90                  95      


Thr Leu Gly Val Arg Ile Leu Asp Thr Cys Ser Arg Asp Thr Tyr Ala 
            100                 105                 110         


Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu Lys Asp Ala 
        115                 120                 125             


Ser Asp Val Lys Cys Ala Asn Gly Asp Pro Pro Ile Phe Thr Lys Pro 
    130                 135                 140                 


Asp Lys Ile Ser Gly Val Ile Gly Ala Ala Ala Ser Ser Val Ser Ile 
145                 150                 155                 160 


Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln Ile Ser Tyr 
                165                 170                 175     


Ala Ser Thr Ala Pro Glu Leu Ser Asp Asn Thr Arg Tyr Asp Phe Phe 
            180                 185                 190         


Ser Arg Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala Met Val Asp 
        195                 200                 205             


Ile Val Thr Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu Ala Ser Glu 
    210                 215                 220                 


Gly Asn Tyr Gly Glu Ser Gly Val Glu Ala Phe Thr Gln Ile Ser Arg 
225                 230                 235                 240 


Glu Ile Gly Gly Val Cys Ile Ala Gln Ser Gln Lys Ile Pro Arg Glu 
                245                 250                 255     


Pro Arg Pro Gly Glu Phe Glu Lys Ile Ile Lys Arg Leu Leu Glu Thr 
            260                 265                 270         


Pro Asn Ala Arg Ala Val Ile Met Phe Ala Asn Glu Asp Asp Ile Arg 
        275                 280                 285             


Arg Ile Leu Glu Ala Ala Lys Lys Leu Asn Gln Ser Gly His Phe Leu 
    290                 295                 300                 


Trp Ile Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro Val Tyr Gln 
305                 310                 315                 320 


Gln Glu Glu Ile Ala Glu Gly Ala Val Thr Ile Leu Pro Lys Arg Ala 
                325                 330                 335     


Ser Ile Asp Gly Phe Asp Arg Tyr Phe Arg Ser Arg Thr Leu Ala Asn 
            340                 345                 350         


Asn Arg Arg Asn Val Trp Phe Ala Glu Phe Trp Glu Glu Asn Phe Gly 
        355                 360                 365             


Cys Lys Leu Gly Ser His Gly Lys Arg Asn Ser His Ile Lys Lys Cys 
    370                 375                 380                 


Thr Gly Leu Glu Arg Ile Ala Arg Asp Ser Ser Tyr Glu Gln Glu Gly 
385                 390                 395                 400 


Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ser Met Ala Tyr Ala Leu 
                405                 410                 415     


His Asn Met His Lys Asp Leu Cys Pro Gly Tyr Ile Gly Leu Cys Pro 
            420                 425                 430         


Arg Met Ser Thr Ile Asp Gly Lys Glu Leu Leu Gly Tyr Ile Arg Ala 
        435                 440                 445             


Val Asn Phe Asn Gly Ser Ala Gly Thr Pro Val Thr Phe Asn Glu Asn 
    450                 455                 460                 


Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe Gln Tyr Gln Ile Thr Asn 
465                 470                 475                 480 


Lys Ser Thr Glu Tyr Lys Val Ile Gly His Trp Thr Asn Gln Leu His 
                485                 490                 495     


Leu Lys Val Glu Asp Met Gln Trp Ala His Arg Glu His Thr His Pro 
            500                 505                 510         


Ala Ser Val Cys Ser Leu Pro Cys Lys Pro Gly Glu Arg Lys Lys Thr 
        515                 520                 525             


Val Lys Gly Val Pro Cys Cys Trp His Cys Glu Arg Cys Glu Gly Tyr 
    530                 535                 540                 


Asn Tyr Gln Val Asp Glu Leu Ser Cys Glu Leu Cys Pro Leu Asp Gln 
545                 550                 555                 560 


Arg Pro Asn Met Asn Arg Thr Gly Cys Gln Leu Ile Pro Ile Ile Lys 
                565                 570                 575     


Leu Glu Trp His Ser Pro Trp Ala Val Val Pro Val Phe Val Ala Ile 
            580                 585                 590         


Leu Gly Ile Ile Ala Thr Thr Phe Val Ile Val Thr Phe Val Arg Tyr 
        595                 600                 605             


Asn Asp Thr Pro Ile Val Arg Ala Ser Gly Arg Glu Leu Ser Tyr Val 
    610                 615                 620                 


Leu Leu Thr Gly Ile Phe Leu Cys Tyr Ser Ile Thr Phe Leu Met Ile 
625                 630                 635                 640 


Ala Ala Pro Asp Thr Ile Ile Cys Ser Phe Arg Arg Val Phe Leu Gly 
                645                 650                 655     


Leu Gly Met Cys Phe Ser Tyr Ala Ala Leu Leu Thr Lys Thr Asn Arg 
            660                 665                 670         


Ile His Arg Ile Phe Glu Gln Gly Lys Lys Ser Val Thr Ala Pro Lys 
        675                 680                 685             


Phe Ile Ser Pro Ala Ser Gln Leu Val Ile Thr Phe Ser Leu Ile Ser 
    690                 695                 700                 


Val Gln Leu Leu Gly Val Phe Val Trp Phe Val Val Asp Pro Pro His 
705                 710                 715                 720 


Ile Ile Ile Asp Tyr Gly Glu Gln Arg Thr Leu Asp Pro Glu Lys Ala 
                725                 730                 735     


Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser Leu Ile Cys Ser 
            740                 745                 750         


Leu Gly Tyr Ser Ile Leu Leu Met Val Thr Cys Thr Val Tyr Ala Ile 
        755                 760                 765             


Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro Ile Gly 
    770                 775                 780                 


Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Ile Pro Ile 
785                 790                 795                 800 


Phe Phe Gly Thr Ala Gln Ser Ala Glu Lys Met Tyr Ile Gln Thr Thr 
                805                 810                 815     


Thr Leu Thr Val Ser Met Ser Leu Ser Ala Ser Val Ser Leu Gly Met 
            820                 825                 830         


Leu Tyr Met Pro Lys Val Tyr Ile Ile Ile Phe His Pro Glu Gln Asn 
        835                 840                 845             


Val Gln Lys Arg Lys Arg Ser Phe Lys Ala Val Val Thr Ala Ala Thr 
    850                 855                 860                 


Met Gln Ser Lys Leu Ile Gln Lys Gly Asn Asp Arg Pro Asn Gly Glu 
865                 870                 875                 880 


Val Lys Ser Glu Leu Cys Glu Ser Leu Glu Thr Asn Ser Lys Ser Ser 
                885                 890                 895     


Val Glu Phe Pro Met Val Lys Ser Gly Ser Thr Ser 
            900                 905             


<210>  46
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Val Cys Glu Gly Lys Arg Ser Ala Ser Cys Pro Cys Phe Phe Leu 
1               5                   10                  15      


Leu Thr Ala Lys Phe Tyr Trp Ile Leu Thr Met Met Gln Arg Thr His 
            20                  25                  30          


Ser Gln Glu Tyr Ala His Ser Ile Arg Val Asp Gly Asp Ile Ile Leu 
        35                  40                  45              


Gly Gly Leu Phe Pro Val His Ala Lys Gly Glu Arg Gly Val Pro Cys 
    50                  55                  60                  


Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu Ala Met Leu 
65                  70                  75                  80  


Tyr Ala Ile Asp Gln Ile Asn Lys Asp Pro Asp Leu Leu Ser Asn Ile 
                85                  90                  95      


Thr Leu Gly Val Arg Ile Leu Asp Thr Cys Ser Arg Asp Thr Tyr Ala 
            100                 105                 110         


Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu Lys Asp Ala 
        115                 120                 125             


Ser Asp Val Lys Cys Ala Asn Gly Asp Pro Pro Ile Phe Thr Lys Pro 
    130                 135                 140                 


Asp Lys Ile Ser Gly Val Ile Gly Ala Ala Ala Ser Ser Val Ser Ile 
145                 150                 155                 160 


Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln Ile Ser Tyr 
                165                 170                 175     


Ala Ser Thr Ala Pro Glu Leu Ser Asp Asn Thr Arg Tyr Asp Phe Phe 
            180                 185                 190         


Ser Arg Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala Met Val Asp 
        195                 200                 205             


Ile Val Thr Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu Ala Ser Glu 
    210                 215                 220                 


Gly Asn Tyr Gly Glu Ser Gly Val Glu Ala Phe Thr Gln Ile Ser Arg 
225                 230                 235                 240 


Glu Ile Gly Gly Val Cys Ile Ala Gln Ser Gln Lys Ile Pro Arg Glu 
                245                 250                 255     


Pro Arg Pro Gly Glu Phe Glu Lys Ile Ile Lys Arg Leu Leu Glu Thr 
            260                 265                 270         


Pro Asn Ala Arg Ala Val Ile Met Phe Ala Asn Glu Asp Asp Ile Arg 
        275                 280                 285             


Arg Ile Leu Glu Ala Ala Lys Lys Leu Asn Gln Ser Gly His Phe Leu 
    290                 295                 300                 


Trp Ile Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro Val Tyr Gln 
305                 310                 315                 320 


Gln Glu Glu Ile Ala Glu Gly Ala Val Thr Ile Leu Pro Lys Arg Ala 
                325                 330                 335     


Ser Ile Asp Gly Phe Asp Arg Tyr Phe Arg Ser Arg Thr Leu Ala Asn 
            340                 345                 350         


Asn Arg Arg Asn Val Trp Phe Ala Glu Phe Trp Glu Glu Asn Phe Gly 
        355                 360                 365             


Cys Lys Leu Gly Ser His Gly Lys Arg Asn Ser His Ile Lys Lys Cys 
    370                 375                 380                 


Thr Gly Leu Glu Arg Ile Ala Arg Asp Ser Ser Tyr Glu Gln Glu Gly 
385                 390                 395                 400 


Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ser Met Ala Tyr Ala Leu 
                405                 410                 415     


His Asn Met His Lys Asp Leu Cys Pro Gly Tyr Ile Gly Leu Cys Pro 
            420                 425                 430         


Arg Met Ser Thr Ile Asp Gly Lys Glu Leu Leu Gly Tyr Ile Arg Ala 
        435                 440                 445             


Val Asn Phe Asn Gly Cys Arg Arg Gly Ile Gln Met Ser Leu Pro Trp 
    450                 455                 460                 


Pro Thr Leu Phe Thr Pro Ser Phe Ser Ser Ser Trp Ala Val Leu Ala 
465                 470                 475                 480 


Leu Leu Ser Leu Leu Met Lys Thr Glu Met Leu Leu Asp Val Met Ile 
                485                 490                 495     


Ser Ser Ser Ile Lys 
            500     


<210>  47
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized - Affinity SNAP polypeptide tag

<400>  47

Met Asp Lys Asp Cys Glu Met Lys Arg Thr Thr Leu Asp Ser Pro Leu 
1               5                   10                  15      


Gly Lys Leu Glu Leu Ser Gly Cys Glu Gln Gly Leu His Arg Ile Ile 
            20                  25                  30          


Phe Leu Gly Lys Gly Thr Ser Ala Ala Asp Ala Val Glu Val Pro Ala 
        35                  40                  45              


Pro Ala Ala Val Leu Gly Gly Pro Glu Pro Leu Met Gln Ala Thr Ala 
    50                  55                  60                  


Trp Leu Asn Ala Tyr Phe His Gln Pro Glu Ala Ile Glu Glu Phe Pro 
65                  70                  75                  80  


Val Pro Ala Leu His His Pro Val Phe Gln Gln Glu Ser Phe Thr Arg 
                85                  90                  95      


Gln Val Leu Trp Lys Leu Leu Lys Val Val Lys Phe Gly Glu Val Ile 
            100                 105                 110         


Ser Tyr Ser His Leu Ala Ala Leu Ala Gly Asn Pro Ala Ala Thr Ala 
        115                 120                 125             


Ala Val Lys Thr Ala Leu Ser Gly Asn Pro Val Pro Ile Leu Ile Pro 
    130                 135                 140                 


Cys His Arg Val Val Gln Gly Asp Leu Asp Val Gly Gly Tyr Glu Gly 
145                 150                 155                 160 


Gly Leu Ala Val Lys Glu Trp Leu Leu Ala His Glu Gly His Arg Leu 
                165                 170                 175     


Gly Lys Pro Gly Leu Gly 
            180         


<210>  48
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized - Affinity SNAP polypeptide tag

<400>  48

Met Asp Lys Asp Cys Glu Met Lys Arg Thr Thr Leu Asp Ser Pro Leu 
1               5                   10                  15      


Gly Lys Leu Glu Leu Ser Gly Cys Glu Gln Gly Leu His Glu Ile Lys 
            20                  25                  30          


Leu Leu Gly Lys Gly Thr Ser Ala Ala Asp Ala Val Glu Val Pro Ala 
        35                  40                  45              


Pro Ala Ala Val Leu Gly Gly Pro Glu Pro Leu Met Gln Ala Thr Ala 
    50                  55                  60                  


Trp Leu Asn Ala Tyr Phe His Gln Pro Glu Ala Ile Glu Glu Phe Pro 
65                  70                  75                  80  


Val Pro Ala Leu His His Pro Val Phe Gln Gln Glu Ser Phe Thr Arg 
                85                  90                  95      


Gln Val Leu Trp Lys Leu Leu Lys Val Val Lys Phe Gly Glu Val Ile 
            100                 105                 110         


Ser Tyr Gln Gln Leu Ala Ala Leu Ala Gly Asn Pro Ala Ala Thr Ala 
        115                 120                 125             


Ala Val Lys Thr Ala Leu Ser Gly Asn Pro Val Pro Ile Leu Ile Pro 
    130                 135                 140                 


Cys His Arg Val Val Ser Ser Ser Gly Ala Val Gly Gly Tyr Glu Gly 
145                 150                 155                 160 


Gly Leu Ala Val Lys Glu Trp Leu Leu Ala His Glu Gly His Arg Leu 
                165                 170                 175     


Gly Lys Pro Gly Leu Gly 
            180         


