                         SEQUENCE LISTING

<110>  Monte Rosa Therapeutics AG
 
<120>  METHODS FOR THE IDENTIFICATION OF DEGRONS

<130>  52271-0004WO1

<140>  PCT/IB2022/050276
<141>  2022-01-13

<150>  US 63/137,082
<151>  2021-01-13

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Glu Ser Glu Glu Glu Asp Glu Met Glu Val 
            20                  25                  30          


Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn Phe 
        35                  40                  45              


Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met Glu 
    50                  55                  60                  


Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val Ile 
65                  70                  75                  80  


Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr Leu 
                85                  90                  95      


Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn Leu 
            100                 105                 110         


Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val Gln 
        115                 120                 125             


Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr Arg 
    130                 135                 140                 


Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile Gly 
145                 150                 155                 160 


Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly Ile 
                165                 170                 175     


Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser Thr 
            180                 185                 190         


Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe Pro 
        195                 200                 205             


Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp Gln 
    210                 215                 220                 


Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp Pro 
225                 230                 235                 240 


Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg Ile 
                245                 250                 255     


Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser Leu 
            260                 265                 270         


Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu Pro 
        275                 280                 285             


Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala Ile 
    290                 295                 300                 


Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser Leu 
305                 310                 315                 320 


Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu Ile 
                325                 330                 335     


Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro His 
            340                 345                 350         


Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu Asn 
        355                 360                 365             


Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr Ala 
    370                 375                 380                 


Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp Lys 
385                 390                 395                 400 


Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly Leu 
                405                 410                 415     


Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu Ile 
            420                 425                 430         


Ser Pro Asp Lys Val Ile Leu Cys Leu 
        435                 440     


<210>  2
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser 
            180                 185                 190         


Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe 
        195                 200                 205             


Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp 
    210                 215                 220                 


Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp 
225                 230                 235                 240 


Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg 
                245                 250                 255     


Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser 
            260                 265                 270         


Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu 
        275                 280                 285             


Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala 
    290                 295                 300                 


Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser 
305                 310                 315                 320 


Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu 
                325                 330                 335     


Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro 
            340                 345                 350         


His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu 
        355                 360                 365             


Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr 
    370                 375                 380                 


Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp 
385                 390                 395                 400 


Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly 
                405                 410                 415     


Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu 
            420                 425                 430         


Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        435                 440         


<210>  3
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln 
1               5                   10                  15      


Val Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln 
            20                  25                  30          


Thr Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg 
        35                  40                  45              


Asn Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn 
    50                  55                  60                  


Val Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala 
65                  70                  75                  80  


Tyr Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala 
                85                  90                  95      


Ile Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp 
            100                 105                 110         


Gly Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro 
        115                 120                 125             


Ser Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile 
    130                 135                 140                 


Phe Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp 
145                 150                 155                 160 


Trp Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser 
                165                 170                 175     


Trp Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp 
            180                 185                 190         


Arg Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp 
        195                 200                 205             


Ser Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys 
    210                 215                 220                 


Leu Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser 
225                 230                 235                 240 


Ala Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr 
                245                 250                 255     


Ser Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn 
            260                 265                 270         


Glu Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn 
        275                 280                 285             


Pro His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn 
    290                 295                 300                 


Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly 
305                 310                 315                 320 


Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly 
                325                 330                 335     


Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp 
            340                 345                 350         


Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp 
        355                 360                 365             


Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
    370                 375                 


<210>  4
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser 
            180                 185                 190         


Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe 
        195                 200                 205             


Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp 
    210                 215                 220                 


Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp 
225                 230                 235                 240 


Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg 
                245                 250                 255     


Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser 
            260                 265                 270         


Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu 
        275                 280                 285             


Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala 
    290                 295                 300                 


Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser 
305                 310                 315                 320 


Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu 
                325                 330                 335     


Ile Phe Arg Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser 
            340                 345                 350         


His Ile Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln 
        355                 360                 365             


Lys Phe Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp 
    370                 375                 380                 


Thr Glu Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
385                 390                 395             


<210>  5
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Leu Gln His Leu Leu Lys Met Ile Phe Arg Ile Gln Gln Ala 
1               5                   10                  15      


Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser Thr Met Ser Ala 
            20                  25                  30          


Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe Pro Ser Lys Pro 
        35                  40                  45              


Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp Gln Lys Tyr Gln 
    50                  55                  60                  


Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp Pro Arg Trp Leu 
65                  70                  75                  80  


Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg Ile Lys Lys Gln 
                85                  90                  95      


Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser Leu Pro Ser Asn 
            100                 105                 110         


Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu Pro Ile Asp Asp 
        115                 120                 125             


Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala Ile Gln Arg Leu 
    130                 135                 140                 


Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser Leu Cys Cys Lys 
145                 150                 155                 160 


Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu Ile Phe Ser Leu 
                165                 170                 175     


Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro His Gly Tyr Val 
            180                 185                 190         


His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu Asn Leu Ile Gly 
        195                 200                 205             


Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr Ala Trp Thr Val 
    210                 215                 220                 


Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp Lys Phe Thr Ala 
225                 230                 235                 240 


Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly Leu Thr Arg Ser 
                245                 250                 255     


Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu Ile Ser Pro Asp 
            260                 265                 270         


Lys Val Ile Leu Cys Leu 
        275             


<210>  6
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Leu Gln His Leu Leu Lys Met Ile Phe Arg Ile Gln Gln Ala 
1               5                   10                  15      


Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser Thr Met Ser Ala 
            20                  25                  30          


Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe Pro Ser Lys Pro 
        35                  40                  45              


Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp Gln Lys Tyr Gln 
    50                  55                  60                  


Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp Pro Arg Trp Leu 
65                  70                  75                  80  


Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg Ile Lys Lys Gln 
                85                  90                  95      


Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser Leu Pro Ser Asn 
            100                 105                 110         


Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu Pro Ile Asp Asp 
        115                 120                 125             


Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala Ile Gln Arg Leu 
    130                 135                 140                 


Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser Leu Cys Cys Lys 
145                 150                 155                 160 


Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu Ile Phe Ser Leu 
                165                 170                 175     


Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro His Gly Tyr Val 
            180                 185                 190         


His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu Asn Leu Ile Gly 
        195                 200                 205             


Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr Ala Trp Thr Val 
    210                 215                 220                 


Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp Lys Phe Thr Ala 
225                 230                 235                 240 


Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly Leu Thr Arg Ser 
                245                 250                 255     


Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu Ile Ser Pro Asp 
            260                 265                 270         


Lys Val Ile Leu Cys Leu 
        275             


<210>  7
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser 
            180                 185                 190         


Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe 
        195                 200                 205             


Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp 
    210                 215                 220                 


Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp 
225                 230                 235                 240 


Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg 
                245                 250                 255     


Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser 
            260                 265                 270         


Leu Pro Ser Asn Pro Ile Val Tyr Phe Pro Leu Leu 
        275                 280                 


<210>  8
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ser Ser Pro Ala Val Asp Val Ser Cys Arg Arg Arg Glu Lys 
1               5                   10                  15      


Arg Arg Gln Leu Asp Ala Arg Arg Ser Lys Cys Arg Ile Arg Leu Gly 
            20                  25                  30          


Gly His Met Glu Gln Trp Cys Leu Leu Lys Glu Arg Leu Gly Phe Ser 
        35                  40                  45              


Leu His Ser Gln Leu Ala Lys Phe Leu Leu Asp Arg Tyr Thr Ser Ser 
    50                  55                  60                  


Gly Cys Val Leu Cys Ala Gly Pro Glu Pro Leu Pro Pro Lys Gly Leu 
65                  70                  75                  80  


Gln Tyr Leu Val Leu Leu Ser His Ala His Ser Arg Glu Cys Ser Leu 
                85                  90                  95      


Val Pro Gly Leu Arg Gly Pro Gly Gly Gln Asp Gly Gly Leu Val Trp 
            100                 105                 110         


Glu Cys Ser Ala Gly His Thr Phe Ser Trp Gly Pro Ser Leu Ser Pro 
        115                 120                 125             


Thr Pro Ser Glu Ala Pro Lys Pro Ala Ser Leu Pro His Thr Thr Arg 
    130                 135                 140                 


Arg Ser Trp Cys Ser Glu Ala Thr Ser Gly Gln Glu Leu Ala Asp Leu 
145                 150                 155                 160 


Glu Ser Glu His Asp Glu Arg Thr Gln Glu Ala Arg Leu Pro Arg Arg 
                165                 170                 175     


Val Gly Pro Pro Pro Glu Thr Phe Pro Pro Pro Gly Glu Glu Glu Gly 
            180                 185                 190         


Glu Glu Glu Glu Asp Asn Asp Glu Asp Glu Glu Glu Met Leu Ser Asp 
        195                 200                 205             


Ala Ser Leu Trp Thr Tyr Ser Ser Ser Pro Asp Asp Ser Glu Pro Asp 
    210                 215                 220                 


Ala Pro Arg Leu Leu Pro Ser Pro Val Thr Cys Thr Pro Lys Glu Gly 
225                 230                 235                 240 


Glu Thr Pro Pro Ala Pro Ala Ala Leu Ser Ser Pro Leu Ala Val Pro 
                245                 250                 255     


Ala Leu Ser Ala Ser Ser Leu Ser Ser Arg Ala Pro Pro Pro Ala Glu 
            260                 265                 270         


Val Arg Val Gln Pro Gln Leu Ser Arg Thr Pro Gln Ala Ala Gln Gln 
        275                 280                 285             


Thr Glu Ala Leu Ala Ser Thr Gly Ser Gln Ala Gln Ser Ala Pro Thr 
    290                 295                 300                 


Pro Ala Trp Asp Glu Asp Thr Ala Gln Ile Gly Pro Lys Arg Ile Arg 
305                 310                 315                 320 


Lys Ala Ala Lys Arg Glu Leu Met Pro Cys Asp Phe Pro Gly Cys Gly 
                325                 330                 335     


Arg Ile Phe Ser Asn Arg Gln Tyr Leu Asn His His Lys Lys Tyr Gln 
            340                 345                 350         


His Ile His Gln Lys Ser Phe Ser Cys Pro Glu Pro Ala Cys Gly Lys 
        355                 360                 365             


Ser Phe Asn Phe Lys Lys His Leu Lys Glu His Met Lys Leu His Ser 
    370                 375                 380                 


Asp Thr Arg Asp Tyr Ile Cys Glu Phe Cys Ala Arg Ser Phe Arg Thr 
385                 390                 395                 400 


Ser Ser Asn Leu Val Ile His Arg Arg Ile His Thr Gly Glu Lys Pro 
                405                 410                 415     


Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg Gln Lys Ala Ser Leu 
            420                 425                 430         


Asn Trp His Gln Arg Lys His Ala Glu Thr Val Ala Ala Leu Arg Phe 
        435                 440                 445             


Pro Cys Glu Phe Cys Gly Lys Arg Phe Glu Lys Pro Asp Ser Val Ala 
    450                 455                 460                 


Ala His Arg Ser Lys Ser His Pro Ala Leu Leu Leu Ala Pro Gln Glu 
465                 470                 475                 480 


Ser Pro Ser Gly Pro Leu Glu Pro Cys Pro Ser Ile Ser Ala Pro Gly 
                485                 490                 495     


Pro Leu Gly Ser Ser Glu Gly Ser Arg Pro Ser Ala Ser Pro Gln Ala 
            500                 505                 510         


Pro Thr Leu Leu Pro Gln Gln 
        515                 


<210>  9
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Ala Asp Glu Gly Gln Asp Met Ser Gln Val Ser Gly Lys Glu 
1               5                   10                  15      


Ser Pro Pro Val Ser Asp Thr Pro Asp Glu Gly Asp Glu Pro Met Pro 
            20                  25                  30          


Ile Pro Glu Asp Leu Ser Thr Thr Ser Gly Gly Gln Gln Ser Ser Lys 
        35                  40                  45              


Ser Asp Arg Val Val Ala Ser Asn Val Lys Val Glu Thr Gln Ser Asp 
    50                  55                  60                  


Glu Glu Asn Gly Arg Ala Cys Glu Met Asn Gly Glu Glu Cys Ala Glu 
65                  70                  75                  80  


Asp Leu Arg Met Leu Asp Ala Ser Gly Glu Lys Met Asn Gly Ser His 
                85                  90                  95      


Arg Asp Gln Gly Ser Ser Ala Leu Ser Gly Val Gly Gly Ile Arg Leu 
            100                 105                 110         


Pro Asn Gly Lys Leu Lys Cys Asp Ile Cys Gly Ile Ile Cys Ile Gly 
        115                 120                 125             


Pro Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg Pro 
    130                 135                 140                 


Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu 
145                 150                 155                 160 


Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His 
                165                 170                 175     


Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu 
            180                 185                 190         


Arg Thr His Ser Val Gly Lys Pro His Lys Cys Gly Tyr Cys Gly Arg 
        195                 200                 205             


Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys His 
    210                 215                 220                 


Asn Tyr Leu Glu Ser Met Gly Leu Pro Gly Thr Leu Tyr Pro Val Ile 
225                 230                 235                 240 


Lys Glu Glu Thr Asn His Ser Glu Met Ala Glu Asp Leu Cys Lys Ile 
                245                 250                 255     


Gly Ser Glu Arg Ser Leu Val Leu Asp Arg Leu Ala Ser Asn Val Ala 
            260                 265                 270         


Lys Arg Lys Ser Ser Met Pro Gln Lys Phe Leu Gly Asp Lys Gly Leu 
        275                 280                 285             


Ser Asp Thr Pro Tyr Asp Ser Ser Ala Ser Tyr Glu Lys Glu Asn Glu 
    290                 295                 300                 


Met Met Lys Ser His Val Met Asp Gln Ala Ile Asn Asn Ala Ile Asn 
305                 310                 315                 320 


Tyr Leu Gly Ala Glu Ser Leu Arg Pro Leu Val Gln Thr Pro Pro Gly 
                325                 330                 335     


Gly Ser Glu Val Val Pro Val Ile Ser Pro Met Tyr Gln Leu His Lys 
            340                 345                 350         


Pro Leu Ala Glu Gly Thr Pro Arg Ser Asn His Ser Ala Gln Asp Ser 
        355                 360                 365             


Ala Val Glu Asn Leu Leu Leu Leu Ser Lys Ala Lys Leu Val Pro Ser 
    370                 375                 380                 


Glu Arg Glu Ala Ser Pro Ser Asn Ser Cys Gln Asp Ser Thr Asp Thr 
385                 390                 395                 400 


Glu Ser Asn Asn Glu Glu Gln Arg Ser Gly Leu Ile Tyr Leu Thr Asn 
                405                 410                 415     


His Ile Ala Pro His Ala Arg Asn Gly Leu Ser Leu Lys Glu Glu His 
            420                 425                 430         


Arg Ala Tyr Asp Leu Leu Arg Ala Ala Ser Glu Asn Ser Gln Asp Ala 
        435                 440                 445             


Leu Arg Val Val Ser Thr Ser Gly Glu Gln Met Lys Val Tyr Lys Cys 
    450                 455                 460                 


Glu His Cys Arg Val Leu Phe Leu Asp His Val Met Tyr Thr Ile His 
465                 470                 475                 480 


Met Gly Cys His Gly Phe Arg Asp Pro Phe Glu Cys Asn Met Cys Gly 
                485                 490                 495     


Tyr His Ser Gln Asp Arg Tyr Glu Phe Ser Ser His Ile Thr Arg Gly 
            500                 505                 510         


Glu His Arg Phe His Met Ser 
        515                 


<210>  10
<211>  1053
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Arg Arg Lys Gln Ala Lys Pro Gln His Ile Asn Ser Glu Glu 
1               5                   10                  15      


Asp Gln Gly Glu Gln Gln Pro Gln Gln Gln Thr Pro Glu Phe Ala Asp 
            20                  25                  30          


Ala Ala Pro Ala Ala Pro Ala Ala Gly Glu Leu Gly Ala Pro Val Asn 
        35                  40                  45              


His Pro Gly Asn Asp Glu Val Ala Ser Glu Asp Glu Ala Thr Val Lys 
    50                  55                  60                  


Arg Leu Arg Arg Glu Glu Thr His Val Cys Glu Lys Cys Cys Ala Glu 
65                  70                  75                  80  


Phe Phe Ser Ile Ser Glu Phe Leu Glu His Lys Lys Asn Cys Thr Lys 
                85                  90                  95      


Asn Pro Pro Val Leu Ile Met Asn Asp Ser Glu Gly Pro Val Pro Ser 
            100                 105                 110         


Glu Asp Phe Ser Gly Ala Val Leu Ser His Gln Pro Thr Ser Pro Gly 
        115                 120                 125             


Ser Lys Asp Cys His Arg Glu Asn Gly Gly Ser Ser Glu Asp Met Lys 
    130                 135                 140                 


Glu Lys Pro Asp Ala Glu Ser Val Val Tyr Leu Lys Thr Glu Thr Ala 
145                 150                 155                 160 


Leu Pro Pro Thr Pro Gln Asp Ile Ser Tyr Leu Ala Lys Gly Lys Val 
                165                 170                 175     


Ala Asn Thr Asn Val Thr Leu Gln Ala Leu Arg Gly Thr Lys Val Ala 
            180                 185                 190         


Val Asn Gln Arg Ser Ala Asp Ala Leu Pro Ala Pro Val Pro Gly Ala 
        195                 200                 205             


Asn Ser Ile Pro Trp Val Leu Glu Gln Ile Leu Cys Leu Gln Gln Gln 
    210                 215                 220                 


Gln Leu Gln Gln Ile Gln Leu Thr Glu Gln Ile Arg Ile Gln Val Asn 
225                 230                 235                 240 


Met Trp Ala Ser His Ala Leu His Ser Ser Gly Ala Gly Ala Asp Thr 
                245                 250                 255     


Leu Lys Thr Leu Gly Ser His Met Ser Gln Gln Val Ser Ala Ala Val 
            260                 265                 270         


Ala Leu Leu Ser Gln Lys Ala Gly Ser Gln Gly Leu Ser Leu Asp Ala 
        275                 280                 285             


Leu Lys Gln Ala Lys Leu Pro His Ala Asn Ile Pro Ser Ala Thr Ser 
    290                 295                 300                 


Ser Leu Ser Pro Gly Leu Ala Pro Phe Thr Leu Lys Pro Asp Gly Thr 
305                 310                 315                 320 


Arg Val Leu Pro Asn Val Met Ser Arg Leu Pro Ser Ala Leu Leu Pro 
                325                 330                 335     


Gln Ala Pro Gly Ser Val Leu Phe Gln Ser Pro Phe Ser Thr Val Ala 
            340                 345                 350         


Leu Asp Thr Ser Lys Lys Gly Lys Gly Lys Pro Pro Asn Ile Ser Ala 
        355                 360                 365             


Val Asp Val Lys Pro Lys Asp Glu Ala Ala Leu Tyr Lys His Lys Cys 
    370                 375                 380                 


Lys Tyr Cys Ser Lys Val Phe Gly Thr Asp Ser Ser Leu Gln Ile His 
385                 390                 395                 400 


Leu Arg Ser His Thr Gly Glu Arg Pro Phe Val Cys Ser Val Cys Gly 
                405                 410                 415     


His Arg Phe Thr Thr Lys Gly Asn Leu Lys Val His Phe His Arg His 
            420                 425                 430         


Pro Gln Val Lys Ala Asn Pro Gln Leu Phe Ala Glu Phe Gln Asp Lys 
        435                 440                 445             


Val Ala Ala Gly Asn Gly Ile Pro Tyr Ala Leu Ser Val Pro Asp Pro 
    450                 455                 460                 


Ile Asp Glu Pro Ser Leu Ser Leu Asp Ser Lys Pro Val Leu Val Thr 
465                 470                 475                 480 


Thr Ser Val Gly Leu Pro Gln Asn Leu Ser Ser Gly Thr Asn Pro Lys 
                485                 490                 495     


Asp Leu Thr Gly Gly Ser Leu Pro Gly Asp Leu Gln Pro Gly Pro Ser 
            500                 505                 510         


Pro Glu Ser Glu Gly Gly Pro Thr Leu Pro Gly Val Gly Pro Asn Tyr 
        515                 520                 525             


Asn Ser Pro Arg Ala Gly Gly Phe Gln Gly Ser Gly Thr Pro Glu Pro 
    530                 535                 540                 


Gly Ser Glu Thr Leu Lys Leu Gln Gln Leu Val Glu Asn Ile Asp Lys 
545                 550                 555                 560 


Ala Thr Thr Asp Pro Asn Glu Cys Leu Ile Cys His Arg Val Leu Ser 
                565                 570                 575     


Cys Gln Ser Ser Leu Lys Met His Tyr Arg Thr His Thr Gly Glu Arg 
            580                 585                 590         


Pro Phe Gln Cys Lys Ile Cys Gly Arg Ala Phe Ser Thr Lys Gly Asn 
        595                 600                 605             


Leu Lys Thr His Leu Gly Val His Arg Thr Asn Thr Ser Ile Lys Thr 
    610                 615                 620                 


Gln His Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val Met 
625                 630                 635                 640 


Leu Gln Gln His Ile Arg Met His Met Gly Gly Gln Ile Pro Asn Thr 
                645                 650                 655     


Pro Leu Pro Glu Asn Pro Cys Asp Phe Thr Gly Ser Glu Pro Met Thr 
            660                 665                 670         


Val Gly Glu Asn Gly Ser Thr Gly Ala Ile Cys His Asp Asp Val Ile 
        675                 680                 685             


Glu Ser Ile Asp Val Glu Glu Val Ser Ser Gln Glu Ala Pro Ser Ser 
    690                 695                 700                 


Ser Ser Lys Val Pro Thr Pro Leu Pro Ser Ile His Ser Ala Ser Pro 
705                 710                 715                 720 


Thr Leu Gly Phe Ala Met Met Ala Ser Leu Asp Ala Pro Gly Lys Val 
                725                 730                 735     


Gly Pro Ala Pro Phe Asn Leu Gln Arg Gln Gly Ser Arg Glu Asn Gly 
            740                 745                 750         


Ser Val Glu Ser Asp Gly Leu Thr Asn Asp Ser Ser Ser Leu Met Gly 
        755                 760                 765             


Asp Gln Glu Tyr Gln Ser Arg Ser Pro Asp Ile Leu Glu Thr Thr Ser 
    770                 775                 780                 


Phe Gln Ala Leu Ser Pro Ala Asn Ser Gln Ala Glu Ser Ile Lys Ser 
785                 790                 795                 800 


Lys Ser Pro Asp Ala Gly Ser Lys Ala Glu Ser Ser Glu Asn Ser Arg 
                805                 810                 815     


Thr Glu Met Glu Gly Arg Ser Ser Leu Pro Ser Thr Phe Ile Arg Ala 
            820                 825                 830         


Pro Pro Thr Tyr Val Lys Val Glu Val Pro Gly Thr Phe Val Gly Pro 
        835                 840                 845             


Ser Thr Leu Ser Pro Gly Met Thr Pro Leu Leu Ala Ala Gln Pro Arg 
    850                 855                 860                 


Arg Gln Ala Lys Gln His Gly Cys Thr Arg Cys Gly Lys Asn Phe Ser 
865                 870                 875                 880 


Ser Ala Ser Ala Leu Gln Ile His Glu Arg Thr His Thr Gly Glu Lys 
                885                 890                 895     


Pro Phe Val Cys Asn Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn 
            900                 905                 910         


Leu Lys Val His Tyr Met Thr His Gly Ala Asn Asn Asn Ser Ala Arg 
        915                 920                 925             


Arg Gly Arg Lys Leu Ala Ile Glu Asn Thr Met Ala Leu Leu Gly Thr 
    930                 935                 940                 


Asp Gly Lys Arg Val Ser Glu Ile Phe Pro Lys Glu Ile Leu Ala Pro 
945                 950                 955                 960 


Ser Val Asn Val Asp Pro Val Val Trp Asn Gln Tyr Thr Ser Met Leu 
                965                 970                 975     


Asn Gly Gly Leu Ala Val Lys Thr Asn Glu Ile Ser Val Ile Gln Ser 
            980                 985                 990         


Gly Gly Val Pro Thr Leu Pro Val  Ser Leu Gly Ala Thr  Ser Val Val 
        995                 1000                 1005             


Asn Asn  Ala Thr Val Ser Lys  Met Asp Gly Ser Gln  Ser Gly Ile 
    1010                 1015                 1020             


Ser Ala  Asp Val Glu Lys Pro  Ser Ala Thr Asp Gly  Val Pro Lys 
    1025                 1030                 1035             


His Gln  Phe Pro His Phe Leu  Glu Glu Asn Lys Ile  Ala Val Ser 
    1040                 1045                 1050             


<210>  11
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Thr Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Thr Met Lys Thr 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Thr Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Leu Phe Leu Ile Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Lys Lys Tyr Arg Asp Asn Arg Thr Arg Gln His Ile Pro Tyr Arg 
                165                 170                 175     


Glu Asp Lys Asn Leu Thr Gly Thr Ala Arg Tyr Ala Ser Ile Asn Ala 
            180                 185                 190         


His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly 
        195                 200                 205             


Tyr Val Leu Met Tyr Phe Asn Arg Thr Ser Leu Pro Trp Gln Gly Leu 
    210                 215                 220                 


Lys Ala Ala Thr Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys 
225                 230                 235                 240 


Met Ser Thr Pro Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe 
                245                 250                 255     


Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro 
            260                 265                 270         


Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Thr Leu 
        275                 280                 285             


Asn His Gln Tyr Asp Tyr Thr Phe Asp Trp Thr Met Leu Lys Gln Lys 
    290                 295                 300                 


Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln 
305                 310                 315                 320 


Thr Pro Thr Gly Lys Gln Thr Asp Lys Thr Lys Ser Asn Met Lys Gly 
                325                 330                 335     


Phe 
    


<210>  12
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Leu Ser Glu Pro Ile Val Glu Asn Gly Glu Thr Glu Met Ser 
1               5                   10                  15      


Pro Glu Glu Ser Trp Glu His Lys Glu Glu Ile Ser Glu Ala Glu Pro 
            20                  25                  30          


Gly Gly Gly Ser Leu Gly Asp Gly Arg Pro Pro Glu Glu Ser Ala His 
        35                  40                  45              


Glu Met Met Glu Glu Glu Glu Glu Ile Pro Lys Pro Lys Ser Val Val 
    50                  55                  60                  


Ala Pro Pro Gly Ala Pro Lys Lys Glu His Val Asn Val Val Phe Ile 
65                  70                  75                  80  


Gly His Val Asp Ala Gly Lys Ser Thr Ile Gly Gly Gln Ile Met Tyr 
                85                  90                  95      


Leu Thr Gly Met Val Asp Lys Arg Thr Leu Glu Lys Tyr Glu Arg Glu 
            100                 105                 110         


Ala Lys Glu Lys Asn Arg Glu Thr Trp Tyr Leu Ser Trp Ala Leu Asp 
        115                 120                 125             


Thr Asn Gln Glu Glu Arg Asp Lys Gly Lys Thr Val Glu Val Gly Arg 
    130                 135                 140                 


Ala Tyr Phe Glu Thr Glu Lys Lys His Phe Thr Ile Leu Asp Ala Pro 
145                 150                 155                 160 


Gly His Lys Ser Phe Val Pro Asn Met Ile Gly Gly Ala Ser Gln Ala 
                165                 170                 175     


Asp Leu Ala Val Leu Val Ile Ser Ala Arg Lys Gly Glu Phe Glu Thr 
            180                 185                 190         


Gly Phe Glu Lys Gly Gly Gln Thr Arg Glu His Ala Met Leu Ala Lys 
        195                 200                 205             


Thr Ala Gly Val Lys His Leu Ile Val Leu Ile Asn Lys Met Asp Asp 
    210                 215                 220                 


Pro Thr Val Asn Trp Ser Asn Glu Arg Tyr Glu Glu Cys Lys Glu Lys 
225                 230                 235                 240 


Leu Val Pro Phe Leu Lys Lys Val Gly Phe Asn Pro Lys Lys Asp Ile 
                245                 250                 255     


His Phe Met Pro Cys Ser Gly Leu Thr Gly Ala Asn Leu Lys Glu Gln 
            260                 265                 270         


Ser Asp Phe Cys Pro Trp Tyr Ile Gly Leu Pro Phe Ile Pro Tyr Leu 
        275                 280                 285             


Asp Asn Leu Pro Asn Phe Asn Arg Ser Val Asp Gly Pro Ile Arg Leu 
    290                 295                 300                 


Pro Ile Val Asp Lys Tyr Lys Asp Met Gly Thr Val Val Leu Gly Lys 
305                 310                 315                 320 


Leu Glu Ser Gly Ser Ile Cys Lys Gly Gln Gln Leu Val Met Met Pro 
                325                 330                 335     


Asn Lys His Asn Val Glu Val Leu Gly Ile Leu Ser Asp Asp Val Glu 
            340                 345                 350         


Thr Asp Thr Val Ala Pro Gly Glu Asn Leu Lys Ile Arg Leu Lys Gly 
        355                 360                 365             


Ile Glu Glu Glu Glu Ile Leu Pro Gly Phe Ile Leu Cys Asp Pro Asn 
    370                 375                 380                 


Asn Leu Cys His Ser Gly Arg Thr Phe Asp Ala Gln Ile Val Ile Ile 
385                 390                 395                 400 


Glu His Lys Ser Ile Ile Cys Pro Gly Tyr Asn Ala Val Leu His Ile 
                405                 410                 415     


His Thr Cys Ile Glu Glu Val Glu Ile Thr Ala Leu Ile Cys Leu Val 
            420                 425                 430         


Asp Lys Lys Ser Gly Glu Lys Ser Lys Thr Arg Pro Arg Phe Val Lys 
        435                 440                 445             


Gln Asp Gln Val Cys Ile Ala Arg Leu Arg Thr Ala Gly Thr Ile Cys 
    450                 455                 460                 


Leu Glu Thr Phe Lys Asp Phe Pro Gln Met Gly Arg Phe Thr Leu Arg 
465                 470                 475                 480 


Asp Glu Gly Lys Thr Ile Ala Ile Gly Lys Val Leu Lys Leu Val Pro 
                485                 490                 495     


Glu Lys Asp 
            


