                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       miCure Therapeutics Ltd.
       CHEN, Alon
       MANASHIROV, Sharon
       MONTEFELTRO, Andres Pablo
 
<120>  MODIFIED MIR-135, CONJUGATED FORM THEREOF, AND USES OF SAME

<130>  89938

<150>  63/138,555
<151>  2021-01-18

<150>  63/272,329
<151>  2021-10-27

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos in-vitro


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphorylated

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2-OMe modification

<400>  1
uauggcuuuu uauuccuaug uga                                               23


<210>  2
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos in-vitro


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2-OMe modification

<400>  2
uauagggauu ggagccgugg cg                                                22


<210>  3
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2-OMe modification

<400>  3
ucauauaggg auuggagccg ug                                                22


<210>  4
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2-OMe modification

<400>  4
ucacauagga auaaaaagcc aua                                               23


<210>  5
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphorylated

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2-OMe modification

<400>  5
uauggcuuuu uauuccuaug uga                                               23


<210>  6
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2-OMe modification

<400>  6
uauagggauu ggagccgugg cg                                                22


<210>  7
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphorylated

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2-OMe modification

<400>  7
uauggcuuuu uauuccuaug uga                                               23


<210>  8
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphorylated

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2-OMe modification

<400>  8
uaauuuaagc uucuuuguuc ugg                                               23


<210>  9
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2-OMe modification

<400>  9
ccagaacaaa gaagcuuaaa uua                                               23


<210>  10
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphorylated

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2-OMe modification

<400>  10
uauggcuuuu cauuccuaug uga                                               23


<210>  11
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2-OMe modification

<400>  11
auguagggcu aaaagccaug gg                                                22


<210>  12
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2-OMe modification

<400>  12
ucauguaggg cuaaaagcca ug                                                22


<210>  13
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Could be conjugated at 5 prime to sertraline or other cell 
       targeting moiety

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2-OMe modification

<400>  13
ucacauagga augaaaagcc aua                                               23


<210>  14
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphorylated

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2-OMe modification

<400>  14
uauggcuuuu cauuccuaug uga                                               23


<210>  15
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2-OMe modification

<400>  15
auguagggcu aaaagccaug gg                                                22


<210>  16
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphorylated

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2-OMe modification

<400>  16
uauggcuuuu cauuccuaug uga                                               23


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  17
atccgcatga atgctgtgta                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  18
gtgggtggtg gaagagacac                                                   20


<210>  19
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  19
agttctgccg ctgatgatg                                                    19


<210>  20
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  20
gcacaaatgg agagtctgat taaa                                              24


<210>  21
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  21
tatggctttt tattcctatg tga                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  22
tatggctttt cattcctatg tga                                               23


<210>  23
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  23
tttgttcgtt cggctcgcgt ga                                                22


<210>  24
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  24
gatgacacgc aaattcgtga a                                                 21


<210>  25
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  25
taaggcacgc ggtgaatgcc                                                   20


<210>  26
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  26
tagcagcacg taaatattgg cg                                                22


<210>  27
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  27
gggtttggat agtacgttcg ca                                                22


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  28
catacgcccc tcctgatgtc                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  29
gtgcaccatc agcaaggacc                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  30
gcgccgaaag tggagtagat                                                   20


<210>  31
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  31
tgacactggc aaaacaatgc a                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  32
ggtccttttc accagcaagc t                                                 21


<210>  33
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  33
tgcaccacca actgcttagc                                                   20


<210>  34
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  34
ggcatggact gtggtcatga g                                                 21


<210>  35
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  35
acttttggta cattgtggct tcaa                                              24


<210>  36
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  36
ccgccaggac aaaccagtat                                                   20


<210>  37
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  mature miR-135b

<400>  37
uauggcuuuu cauuccuaug uga                                               23


<210>  38
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  mature miR-135b*

<400>  38
auguagggcu aaaagccaug gg                                                22


<210>  39
<211>  97
<212>  RNA
<213>  Artificial sequence

<220>
<223>  miR-135b microRNA precursor

<400>  39
cacucugcug uggccuaugg cuuuucauuc cuaugugauu gcugucccaa acucauguag       60

ggcuaaaagc caugggcuac agugaggggc gagcucc                                97


<210>  40
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNA oligonucleotide complementary to miR-135b

<400>  40
ucacauagga augaaaagcc aua                                               23


<210>  41
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphorylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2-O-MOE-5-Me

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  2-OMe modification

<400>  41
uuauggcuuu ucauuccuau guga                                              24


<210>  42
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphorylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2-O-MOE-5-Me

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  phosphorothioate bond

<400>  42
uuauggcuuu ucauuccuau gugaaa                                            26


<210>  43
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphorylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2-O-MOE-5-Me

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  2-OMe modification

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  phosphorothioate bond

<400>  43
uuauggcuuu ucauuccuau gugaaa                                            26


<210>  44
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphorylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2-O-MOE-5-Me

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(26)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  2-OMe modification

<400>  44
uuauggcuuu ucauuccuau gugaaa                                            26


<210>  45
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphorylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2-O-MOE-5-Me

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(26)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  2-OMe modification

<400>  45
uuauggcuuu ucauuccuau gugaaa                                            26


<210>  46
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' phosphorylated

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2-O-MOE-5-Me

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (15)..(26)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-fluoro

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  2-OMe modification

<400>  46
uuauggcuuu ucauuccuau gugaaa                                            26


<210>  47
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-135 mimetic oligos


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-Me

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Could be conjugated at 5 prime to sertraline or other cell 
       targeting moiety

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-O-Me

<400>  47
ucacauagga augaaaagcc aua                                               23


