                         SEQUENCE LISTING
 
<110>  BeiGene, Ltd.
 
<120>  METHODS OF CANCER TREATMENT USING ANTI-TIGIT ANTIBODIES IN COMBINATION WITH ANTI-PD1 ANTIBODIES

<130>  F22W0881PCT

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     


Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         


Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             


Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 


Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 


Thr Glu Thr Gly 
                


<210>  2
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro 
        115                 120 


<210>  3
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  3

Asp Tyr Tyr Met Tyr 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  4

Tyr Ile Thr Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  5

Gln Thr Asn Tyr Asp Phe Thr Met Asp Tyr 
1               5                   10  


<210>  6
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  6

Lys Ala Ser Gln Asp Val Gly Thr Ser Val Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  7

Trp Ala Ser Ala Arg His Thr 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  9
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  9

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Val Ser Arg Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Asn Tyr Asp Phe Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  10
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  10
gaagtgaagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc cctgaaactc       60

tcctgtgcaa cctctggatt cactttcagt gactattaca tgtattggat tcggcagact      120

ccagagaaga ggctggagtg ggtcgcatac attactaagg gtggtggtag cacctattat      180

ccagacactg taaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaagtga gccgtctgaa gtctgaggac acagccatat attactgtgc aagacagact      300

aactacgact ttactatgga ctactggggt caaggaacct cagtcacggt ctcctca         357


<210>  11
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  11

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr Ser 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ala Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  12
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  12
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc       60

atcatctgca aggccagtca ggatgtgggt acttctgtag cctggtatca acagaaacca      120

gggcaatctc ctaacctact gatttactgg gcatccgccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtacagtct      240

gaagacttgg cagattattt ctgtcagcaa tatagcagtt atcctctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu1217-1-1 HCDR2

<400>  13

Tyr Ile Thr Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu1217-1-1 VH pro

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Asn Tyr Asp Phe Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  15
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu1217-1-1 VH DNA

<400>  15
gaggtgcagc tggtggagag cggaggagga ctggtgcagc ctggaggcag cctgagactg       60

agctgcgcca ccagcggctt caccttctcc gactactaca tgtactggat caggcaggcc      120

cctggcaaag gcctggagtg ggtggcctac atcaccaagg gcggcggcag cacctactac      180

cccgatagcg tgaagggcag gttcaccatc agcagggaca acgccaagaa caccctgtac      240

ctgcagatga acagcctgag ggccgaggat accgccgtgt actactgcgc caggcagacc      300

aactacgact tcaccatgga ctactggggc cagggcacac tggtgaccgt gagcagc         357


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu1217-1-1 VK pro

<400>  16

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Val Gly Thr Ser 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ala Arg His Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  17
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu1217-1-1 VK DNA

<400>  17
gagatcgtga tgacccagag ccctgccaca ctgagcgtga gccctggcga gagagccacc       60

ctgagctgca aggccagcca ggatgtgggc accagcgtgg cctggtacca gcagaaaccc      120

ggccaggctc ccaggctgct gatctactgg gccagcgcca gacacacagg cgtgcctgcc      180

agatttagcg gcagcggcag cggcaccgag tttaccctga ccatcagcag cctgcagtcc      240

gaggacttcg ccgtgtacta ctgccagcag tacagcagct accccctgac attcggcggc      300

ggcaccaagg tggagatcaa g                                                321


<210>  18
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1mf

<400>  18

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Pro Ala Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        115                 120                 125             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    130                 135                 140                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
145                 150                 155                 160 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                165                 170                 175     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            180                 185                 190         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        195                 200                 205             


Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    210                 215                 220                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
225                 230                 235                 240 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                245                 250                 255     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            260                 265                 270         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        275                 280                 285             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    290                 295                 300                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
305                 310                 315                 320 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 


<210>  19
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu1217-2-2 VH pro

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Asn Tyr Asp Phe Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  20
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu1217-2-2 VH DNA

<400>  20
gaggtgcagc tggtggagag cggaggagga ctggtgcagc ctggaggcag cctgagactg       60

agctgcgccg ccagcggctt caccttctcc gactactaca tgtactgggt caggcaggcc      120

cctggcaaag gcctggagtg ggtggcctac atcaccaagg gcggcggcag cacctactac      180

cccgatagcg tgaagggcag gttcaccatc agcagggaca acgccaagaa caccctgtac      240

ctgcagatga acagcctgag ggccgaggat accgccgtgt actactgcgc caggcagacc      300

aactacgact tcaccatgga ctactggggc cagggcacac tggtgaccgt gagcagc         357


<210>  21
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu1217-2-2 VK pro

<400>  21

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Val Gly Thr Ser 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ala Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  22
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu1217-2-2 VK DNA

<400>  22
gagatcgtga tgacccagag ccctgccaca ctgagcgtga gccctggcga gagagccacc       60

ctgagctgca aggccagcca ggatgtgggc accagcgtgg cctggtacca gcagaaaccc      120

ggccaggctc ccaggctgct gatctactgg gccagcgcca gacacacagg catccctgcc      180

agatttagcg gcagcggcag cggcaccgag tttaccctga ccatcagcag cctgcagtcc      240

gaggacttcg ccgtgtacta ctgccagcag tacagcagct accccctgac attcggcggc      300

ggcaccaagg tggagatcaa g                                                321


<210>  23
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10A7 VH pro

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Arg Ser Gly Ser Gly Ile Val Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Pro Leu Gly His Asn Thr Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  24
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10A7 VK pro

<400>  24

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Tyr Tyr Ser 
            20                  25                  30          


Gly Val Lys Glu Asn Leu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Ile Arg Phe Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Ile Asn Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<400>  25

Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>


<400>  26

Val Ile Tyr Ala Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<400>  27

Ala Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10 



<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>

<400>  28

Lys Ser Ser Glu Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<400>  29

Tyr Ala Phe His Arg Phe Thr 
1               5     



<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<400>  30

His Gln Ala Tyr Ser Ser Pro Tyr Thr 
1               5       


<210>  31
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B6 DNA-VH

<400>  31

caggtgcagc tgcaggagtc gggaccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctgggtt ttcattaacc agctatggtg tacactggat ccggcagccc      120

ccagggaagg gactggagtg gatcggggtc atatacgccg atggaagcac aaattataat      180

ccctccctca agagtcgagt gaccatatca aaagacacct ccaagaacca ggtttccctg      240

aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agcctatggt      300

aactactggt acatcgatgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  32
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B6 VH

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Ala Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  33
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B6 VL

<400>  33

gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcga gagtgtgagt aatgatgtag cttggtacca gcagaaacca      120

ggacagcctc ctaagctgct cattaactat gcatttcatc gcttcactgg ggtccctgac      180

cgattcagtg gcagcgggta tgggacagat ttcactctca ccatcagcag cctgcaggct      240

gaagatgtgg cagtttatta ctgtcaccag gcttatagtt ctccgtacac gtttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  34
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B6 VL

<400>  34

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Tyr Ala Phe His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

 

<210>  35
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huIgG4mt10 pro

<400>  35

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Ala Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325    