                         SEQUENCE LISTING

<110>  The Broad Institute, Inc.
 
<120>  TRACKING APOBEC MUTATIONAL SIGNATURES IN TUMOR CELLS

<130>  B1195.70123WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/140,706
<151>  2021-01-22

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His 
            20                  25                  


<210>  2
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  3
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 
            20                  25                  30          


Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu 
        35                  40                  45              


Leu Trp Asp Thr Gly Val Phe Arg Gly Gln Val Tyr Phe Lys Pro Gln 
    50                  55                  60                  


Tyr His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu 
65                  70                  75                  80  


Pro Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro 
                85                  90                  95      


Cys Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ser Glu His Pro 
            100                 105                 110         


Asn Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu 
        115                 120                 125             


Arg Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg 
    130                 135                 140                 


Val Thr Ile Met Asp Tyr Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Glu Gly Gln Gln Phe Met Pro Trp Tyr Lys Phe Asp Glu 
                165                 170                 175     


Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Tyr Leu 
            180                 185                 190         


Met Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro Leu Val 
        195                 200                 205             


Leu Arg Arg Arg Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp 
    210                 215                 220                 


Asn Gly Thr Trp Val Leu Met Asp Gln His Met Gly Phe Leu Cys Asn 
225                 230                 235                 240 


Glu Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu 
                245                 250                 255     


Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile 
            260                 265                 270         


Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly 
        275                 280                 285             


Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg 
    290                 295                 300                 


Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys 
305                 310                 315                 320 


Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met 
                325                 330                 335     


Thr Tyr Asp Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Tyr Arg Gln 
            340                 345                 350         


Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser Gln Ala 
        355                 360                 365             


Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 
    370                 375                 380         


<210>  4
<211>  1251
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Arg Gly Gly Trp Arg Lys Arg Ala Glu Asn Asp Gly Trp Glu 
1               5                   10                  15      


Thr Trp Gly Gly Tyr Met Ala Ala Lys Val Gln Lys Leu Glu Glu Gln 
            20                  25                  30          


Phe Arg Ser Asp Ala Ala Met Gln Lys Asp Gly Thr Ser Ser Thr Ile 
        35                  40                  45              


Phe Ser Gly Val Ala Ile Tyr Val Asn Gly Tyr Thr Asp Pro Ser Ala 
    50                  55                  60                  


Glu Glu Leu Arg Lys Leu Met Met Leu His Gly Gly Gln Tyr His Val 
65                  70                  75                  80  


Tyr Tyr Ser Arg Ser Lys Thr Thr His Ile Ile Ala Thr Asn Leu Pro 
                85                  90                  95      


Asn Ala Lys Ile Lys Glu Leu Lys Gly Glu Lys Val Ile Arg Pro Glu 
            100                 105                 110         


Trp Ile Val Glu Ser Ile Lys Ala Gly Arg Leu Leu Ser Tyr Ile Pro 
        115                 120                 125             


Tyr Gln Leu Tyr Thr Lys Gln Ser Ser Val Gln Lys Gly Leu Ser Phe 
    130                 135                 140                 


Asn Pro Val Cys Arg Pro Glu Asp Pro Leu Pro Gly Pro Ser Asn Ile 
145                 150                 155                 160 


Ala Lys Gln Leu Asn Asn Arg Val Asn His Ile Val Lys Lys Ile Glu 
                165                 170                 175     


Thr Glu Asn Glu Val Lys Val Asn Gly Met Asn Ser Trp Asn Glu Glu 
            180                 185                 190         


Asp Glu Asn Asn Asp Phe Ser Phe Val Asp Leu Glu Gln Thr Ser Pro 
        195                 200                 205             


Gly Arg Lys Gln Asn Gly Ile Pro His Pro Arg Gly Ser Thr Ala Ile 
    210                 215                 220                 


Phe Asn Gly His Thr Pro Ser Ser Asn Gly Ala Leu Lys Thr Gln Asp 
225                 230                 235                 240 


Cys Leu Val Pro Met Val Asn Ser Val Ala Ser Arg Leu Ser Pro Ala 
                245                 250                 255     


Phe Ser Gln Glu Glu Asp Lys Ala Glu Lys Ser Ser Thr Asp Phe Arg 
            260                 265                 270         


Asp Cys Thr Leu Gln Gln Leu Gln Gln Ser Thr Arg Asn Thr Asp Ala 
        275                 280                 285             


Leu Arg Asn Pro His Arg Thr Asn Ser Phe Ser Leu Ser Pro Leu His 
    290                 295                 300                 


Ser Asn Thr Lys Ile Asn Gly Ala His His Ser Thr Val Gln Gly Pro 
305                 310                 315                 320 


Ser Ser Thr Lys Ser Thr Ser Ser Val Ser Thr Phe Ser Lys Ala Ala 
                325                 330                 335     


Pro Ser Val Pro Ser Lys Pro Ser Asp Cys Asn Phe Ile Ser Asn Phe 
            340                 345                 350         


Tyr Ser His Ser Arg Leu His His Ile Ser Met Trp Lys Cys Glu Leu 
        355                 360                 365             


Thr Glu Phe Val Asn Thr Leu Gln Arg Gln Ser Asn Gly Ile Phe Pro 
    370                 375                 380                 


Gly Arg Glu Lys Leu Lys Lys Met Lys Thr Gly Arg Ser Ala Leu Val 
385                 390                 395                 400 


Val Thr Asp Thr Gly Asp Met Ser Val Leu Asn Ser Pro Arg His Gln 
                405                 410                 415     


Ser Cys Ile Met His Val Asp Met Asp Cys Phe Phe Val Ser Val Gly 
            420                 425                 430         


Ile Arg Asn Arg Pro Asp Leu Lys Gly Lys Pro Val Ala Val Thr Ser 
        435                 440                 445             


Asn Arg Gly Thr Gly Arg Ala Pro Leu Arg Pro Gly Ala Asn Pro Gln 
    450                 455                 460                 


Leu Glu Trp Gln Tyr Tyr Gln Asn Lys Ile Leu Lys Gly Lys Ala Ala 
465                 470                 475                 480 


Asp Ile Pro Asp Ser Ser Leu Trp Glu Asn Pro Asp Ser Ala Gln Ala 
                485                 490                 495     


Asn Gly Ile Asp Ser Val Leu Ser Arg Ala Glu Ile Ala Ser Cys Ser 
            500                 505                 510         


Tyr Glu Ala Arg Gln Leu Gly Ile Lys Asn Gly Met Phe Phe Gly His 
        515                 520                 525             


Ala Lys Gln Leu Cys Pro Asn Leu Gln Ala Val Pro Tyr Asp Phe His 
    530                 535                 540                 


Ala Tyr Lys Glu Val Ala Gln Thr Leu Tyr Glu Thr Leu Ala Ser Tyr 
545                 550                 555                 560 


Thr His Asn Ile Glu Ala Val Ser Cys Asp Glu Ala Leu Val Asp Ile 
                565                 570                 575     


Thr Glu Ile Leu Ala Glu Thr Lys Leu Thr Pro Asp Glu Phe Ala Asn 
            580                 585                 590         


Ala Val Arg Met Glu Ile Lys Asp Gln Thr Lys Cys Ala Ala Ser Val 
        595                 600                 605             


Gly Ile Gly Ser Asn Ile Leu Leu Ala Arg Met Ala Thr Arg Lys Ala 
    610                 615                 620                 


Lys Pro Asp Gly Gln Tyr His Leu Lys Pro Glu Glu Val Asp Asp Phe 
625                 630                 635                 640 


Ile Arg Gly Gln Leu Val Thr Asn Leu Pro Gly Val Gly His Ser Met 
                645                 650                 655     


Glu Ser Lys Leu Ala Ser Leu Gly Ile Lys Thr Cys Gly Asp Leu Gln 
            660                 665                 670         


Tyr Met Thr Met Ala Lys Leu Gln Lys Glu Phe Gly Pro Lys Thr Gly 
        675                 680                 685             


Gln Met Leu Tyr Arg Phe Cys Arg Gly Leu Asp Asp Arg Pro Val Arg 
    690                 695                 700                 


Thr Glu Lys Glu Arg Lys Ser Val Ser Ala Glu Ile Asn Tyr Gly Ile 
705                 710                 715                 720 


Arg Phe Thr Gln Pro Lys Glu Ala Glu Ala Phe Leu Leu Ser Leu Ser 
                725                 730                 735     


Glu Glu Ile Gln Arg Arg Leu Glu Ala Thr Gly Met Lys Gly Lys Arg 
            740                 745                 750         


Leu Thr Leu Lys Ile Met Val Arg Lys Pro Gly Ala Pro Val Glu Thr 
        755                 760                 765             


Ala Lys Phe Gly Gly His Gly Ile Cys Asp Asn Ile Ala Arg Thr Val 
    770                 775                 780                 


Thr Leu Asp Gln Ala Thr Asp Asn Ala Lys Ile Ile Gly Lys Ala Met 
785                 790                 795                 800 


Leu Asn Met Phe His Thr Met Lys Leu Asn Ile Ser Asp Met Arg Gly 
                805                 810                 815     


Val Gly Ile His Val Asn Gln Leu Val Pro Thr Asn Leu Asn Pro Ser 
            820                 825                 830         


Thr Cys Pro Ser Arg Pro Ser Val Gln Ser Ser His Phe Pro Ser Gly 
        835                 840                 845             


Ser Tyr Ser Val Arg Asp Val Phe Gln Val Gln Lys Ala Lys Lys Ser 
    850                 855                 860                 


Thr Glu Glu Glu His Lys Glu Val Phe Arg Ala Ala Val Asp Leu Glu 
865                 870                 875                 880 


Ile Ser Ser Ala Ser Arg Thr Cys Thr Phe Leu Pro Pro Phe Pro Ala 
                885                 890                 895     


His Leu Pro Thr Ser Pro Asp Thr Asn Lys Ala Glu Ser Ser Gly Lys 
            900                 905                 910         


Trp Asn Gly Leu His Thr Pro Val Ser Val Gln Ser Arg Leu Asn Leu 
        915                 920                 925             


Ser Ile Glu Val Pro Ser Pro Ser Gln Leu Asp Gln Ser Val Leu Glu 
    930                 935                 940                 


Ala Leu Pro Pro Asp Leu Arg Glu Gln Val Glu Gln Val Cys Ala Val 
945                 950                 955                 960 


Gln Gln Ala Glu Ser His Gly Asp Lys Lys Lys Glu Pro Val Asn Gly 
                965                 970                 975     


Cys Asn Thr Gly Ile Leu Pro Gln Pro Val Gly Thr Val Leu Leu Gln 
            980                 985                 990         


Ile Pro Glu Pro Gln Glu Ser Asn  Ser Asp Ala Gly Ile  Asn Leu Ile 
        995                 1000                 1005             


Ala Leu  Pro Ala Phe Ser Gln  Val Asp Pro Glu Val  Phe Ala Ala 
    1010                 1015                 1020             


Leu Pro  Ala Glu Leu Gln Arg  Glu Leu Lys Ala Ala  Tyr Asp Gln 
    1025                 1030                 1035             


Arg Gln  Arg Gln Gly Glu Asn  Ser Thr His Gln Gln  Ser Ala Ser 
    1040                 1045                 1050             


Ala Ser  Val Pro Lys Asn Pro  Leu Leu His Leu Lys  Ala Ala Val 
    1055                 1060                 1065             


Lys Glu  Lys Lys Arg Asn Lys  Lys Lys Lys Thr Ile  Gly Ser Pro 
    1070                 1075                 1080             


Lys Arg  Ile Gln Ser Pro Leu  Asn Asn Lys Leu Leu  Asn Ser Pro 
    1085                 1090                 1095             


Ala Lys  Thr Leu Pro Gly Ala  Cys Gly Ser Pro Gln  Lys Leu Ile 
    1100                 1105                 1110             


Asp Gly  Phe Leu Lys His Glu  Gly Pro Pro Ala Glu  Lys Pro Leu 
    1115                 1120                 1125             


Glu Glu  Leu Ser Ala Ser Thr  Ser Gly Val Pro Gly  Leu Ser Ser 
    1130                 1135                 1140             


Leu Gln  Ser Asp Pro Ala Gly  Cys Val Arg Pro Pro  Ala Pro Asn 
    1145                 1150                 1155             


Leu Ala  Gly Ala Val Glu Phe  Asn Asp Val Lys Thr  Leu Leu Arg 
    1160                 1165                 1170             


Glu Trp  Ile Thr Thr Ile Ser  Asp Pro Met Glu Glu  Asp Ile Leu 
    1175                 1180                 1185             


Gln Val  Val Lys Tyr Cys Thr  Asp Leu Ile Glu Glu  Lys Asp Leu 
    1190                 1195                 1200             


Glu Lys  Leu Asp Leu Val Ile  Lys Tyr Met Lys Arg  Leu Met Gln 
    1205                 1210                 1215             


Gln Ser  Val Glu Ser Val Trp  Asn Met Ala Phe Asp  Phe Ile Leu 
    1220                 1225                 1230             


Asp Asn  Val Gln Val Val Leu  Gln Gln Thr Tyr Gly  Ser Thr Leu 
    1235                 1240                 1245             


Lys Val  Thr 
    1250     


<210>  5
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  5
attattatta ttattattat ttcatttatt tatttattta                             40


<210>  6
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  6
attattatta ttgcaagctg ttcagcttgc tgaatttatt                             40


