                         SEQUENCE LISTING

<110>  Tufts Medical Center, Inc.
 
<120>  METHODS OF MITIGATING MYOCARDIAL DAMAGE DUE TO EXTRACORPOREAL 
       MEMBRANE OXYGENATION

<130>  00398-561WO2

<150>  US 63/140,651
<151>  2021-01-22

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is 2',6'-dimethylphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is 2',6'-dimethyltyrosine

<400>  1

Xaa Xaa Xaa Lys 
1               


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is 2',6'-dimethylphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Arg

<400>  2

Xaa Xaa Phe Lys 
1               


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is 2',6'-dimethyltyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ornithine

<400>  3

Xaa Xaa Phe Xaa 
1               


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is 2',6'-dimethyltyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is 2-amino-heptanoicacid

<400>  4

Xaa Xaa Phe Xaa 
1               


<210>  5
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is 2',6'-dimethyltyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Arg

<400>  5

Xaa Xaa Phe Lys 
1               


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is 2',6'-dimethyltyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-citrulline

<400>  6

Xaa Xaa Phe Lys 
1               


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Phe

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-Trp

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-Tyr

<400>  7

Ala Xaa Xaa Tyr Lys Xaa His Xaa Gly Phe 
1               5                   10  


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Leu

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-Tyr

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-Lys

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is D-Trp

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is D-Phe

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is D-Arg

<400>  8

Arg Xaa Xaa Phe Lys Glu Xaa Arg Xaa Lys Xaa Tyr Xaa Gly 
1               5                   10                  


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-Phe

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is D-Tyr

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is D-His

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is D-Phe

<400>  9

Asp Arg Xaa Cys Phe Xaa Xaa Tyr Arg Xaa Trp Xaa Tyr Xaa Lys Phe 
1               5                   10                  15      


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Trp

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-His

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-Gly

<400>  10

Asp Xaa Lys Tyr Xaa Phe Arg Xaa Lys 
1               5                   


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is 2',6'-dimethyltyrosine

<400>  11

Xaa Xaa Lys Phe 
1               


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-Glu

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-His

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-Val

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is D-Tyr

<400>  12

Xaa Asp Lys Xaa Xaa Phe Phe Xaa Tyr Arg Tyr Xaa Arg His Phe 
1               5                   10                  15  


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-His

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-Phe

<400>  13

Xaa Glu Lys Tyr Xaa Arg 
1               5       


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-His

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-Phe

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-Asp

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-Asp

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-His

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is D-Lys

<400>  14

Xaa Lys Tyr Xaa Glu Xaa Xaa Xaa Xaa Arg Trp 
1               5                   10      


<210>  15
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-Tyr

<400>  15

Xaa Trp Lys 
1           


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-Lys

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-Val

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-His

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is D-Gly

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is D-Met

<400>  16

Glu Arg Xaa Tyr Xaa Phe Xaa Trp Arg Xaa Tyr Arg Xaa 
1               5                   10              


<210>  17
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is D-His

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is D-Lys

<400>  17

Gly Ala Lys Phe Xaa Glu Arg Tyr His Xaa Xaa Asp Tyr Trp Xaa Trp 
1               5                   10                  15      


His Xaa Asp 
            


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Phe

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-Arg

<400>  18

Gly Xaa Lys His Xaa Tyr 
1               5       


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-Asp

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is D-Tyr

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is D-Lys

<400>  19

His Tyr Xaa Trp Lys Phe Xaa Ala Arg Cys Xaa His Phe Xaa Tyr His 
1               5                   10                  15      


Ser 
    


<210>  20
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Arg

<400>  20

Lys Xaa Tyr 
1           


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Gln

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-Phe

<400>  21

Lys Xaa Tyr Arg Xaa Trp 
1               5       


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-Tyr

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-His

<400>  22

Lys Trp Xaa Arg Asn Phe Tyr Xaa 
1               5               


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-Arg

<400>  23

Met Tyr Xaa Phe Arg 
1               5   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-Lys

<400>  24

Met Tyr Xaa Phe Arg 
1               5   


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-His

<400>  25

Phe Arg Xaa Asp 
1               


<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is 2',6'-dimethyltyrosine

<400>  26

Phe Xaa Xaa Lys 
1               


<210>  27
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Arg

<400>  27

Phe Xaa His 
1           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-Arg

<400>  28

Phe Xaa Lys Trp Tyr Xaa His 
1               5           


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Arg

<400>  29

Phe Xaa Phe Lys 
1               


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-Tyr

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-Lys

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is D-Arg

<400>  30

Phe Phe Xaa Arg Glu Asp Xaa Arg Xaa His Phe 
1               5                   10      


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-Lys

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-Lys

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is D-Tyr

<400>  31

Phe Tyr Lys Xaa Trp His Xaa Xaa Glu Arg Xaa Thr 
1               5                   10          


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-His

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-His

<400>  32

Thr Gly Tyr Arg Xaa Phe Trp Xaa Lys 
1               5                   


<210>  33
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-Lys

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is D-Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is D-Tyr

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is D-His

<400>  33

Thr Tyr Arg Xaa Trp Tyr Glu Asp Xaa Xaa His Phe Xaa Gly Val Ile 
1               5                   10                  15      


Xaa Arg Tyr Lys 
            20  


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Lys

<400>  34

Trp Xaa Tyr Arg 
1               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-Asp

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-His

<400>  35

Trp Lys Phe Xaa Arg Tyr Xaa Lys 
1               5               


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-Lys

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-Lys

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is D-Tyr

<400>  36

Tyr Asp Xaa Tyr Phe Xaa Xaa Phe Pro Xaa His Lys 
1               5                   10          


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Arg

<400>  37

Tyr Xaa Phe Lys Glu 
1               5   


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Arg

<400>  38

Tyr Xaa Phe Lys 
1               


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-His

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is D-His

<400>  39

Tyr Xaa Phe Xaa Asp Lys Xaa His Trp Xaa Phe 
1               5                   10      


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-Gly

<400>  40

Tyr His Xaa Met 
1               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Lys

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-Phe

<400>  41

Val Xaa His Tyr Xaa Ser Tyr Arg 
1               5               


