                         SEQUENCE LISTING

<110>  THE UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER
 
<120>  POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) INHIBITORS AGAINST COVID 
       MACRODOMAIN AND METHODS OF USING THE SAME

<130>  4443.004PC01

<150>  US 63/140,912
<151>  2021-01-24


<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alvi pompejana MacroD2 (gp30765.t1)

<400>  1

Met Leu Thr Lys Arg Ile Leu Ala Gly Arg Arg Leu Met Ser Ala Asn 
1               5                   10                  15      


Arg His Arg Pro Ile Pro Asp Arg Ile Cys Ser Leu Arg Arg Gln Ser 
            20                  25                  30          


Arg Ala Thr Phe Ser Ser Gln Ser Asp Arg Gly Ser Asp Ser Leu Ile 
        35                  40                  45              


Pro Arg Val Phe Arg Thr Ile Val Gly Trp Phe Ala Ala His Leu Pro 
    50                  55                  60                  


Arg Arg Gly Glu Gly Asn Gly Leu Gly Leu Asp Glu Asp Glu Lys Asp 
65                  70                  75                  80  


Ala Leu Asn Val Asn Ser Gln His Ala Lys Lys Lys Gln Lys Trp Gln 
                85                  90                  95      


Ile Glu Lys Glu Glu Tyr Leu Lys Met Pro Ile Ser Glu Lys Arg Lys 
            100                 105                 110         


Ile Tyr Lys Thr Gln Tyr Val Thr Leu Asp Ser Val Pro Thr Trp Pro 
        115                 120                 125             


Glu Tyr Tyr Lys Lys Asn Leu Glu Ala Ser Lys Val Lys Pro Ser Lys 
    130                 135                 140                 


Glu Pro Val Asp Glu Ala Leu Asn Ser Lys Val Ser Leu Trp Cys Gly 
145                 150                 155                 160 


Asp Ile Thr Thr Leu Glu Ile Asp Cys Ile Val Asn Ala Ala Asn Glu 
                165                 170                 175     


Ser Leu Leu Gly Gly Gly Gly Val Asp Gly Ala Ile His Arg Ala Ala 
            180                 185                 190         


Gly Pro Thr Leu Leu Ala Glu Cys Arg Thr Ala Cys Gly Cys Lys Thr 
        195                 200                 205             


Gly Asp Ala Lys Ile Thr Gly Gly Tyr Arg Leu Pro Ala Lys Tyr Ile 
    210                 215                 220                 


Ile His Thr Val Gly Pro Arg Tyr His Gly Asp Glu Lys Leu Arg Ser 
225                 230                 235                 240 


Cys Tyr Lys Lys Ser Leu Asp Leu Met Ile Glu Asn Asn Leu His Ser 
                245                 250                 255     


Ile Ala Phe Pro Cys Ile Ser Thr Gly Ile Tyr Gly Phe Pro Gly Glu 
            260                 265                 270         


Arg Ala Ala Asp Ile Ala Leu Thr Thr Val Lys Asp Phe Leu Gln Lys 
        275                 280                 285             


His Lys Asp Lys Val Asp Arg Ile Ile Phe Cys Leu Phe Thr Arg Asp 
    290                 295                 300                 


Asp Val Asn Ile Tyr Glu Ser Lys Met Pro Thr Tyr Phe Pro Val Glu 
305                 310                 315                 320 


Gly Gln Cys Ser Asp His Glu Asp Gln Thr Thr Asp Asp Asn Pro Asn 
                325                 330                 335     


Val Asp Leu Pro Gly Lys Pro Ser Asp Lys Asn Ser Val Pro Lys Leu 
            340                 345                 350         


<210>  2
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alvi pompejana GDAP2 (g72977.t1)

<400>  2

Met Asp Asp Pro Leu Ala Ala Pro Thr Gln Ala Thr Val Asp His Thr 
1               5                   10                  15      


Lys Leu Val Arg Trp Asn Gln Thr Asn Val Pro Glu Tyr Asn Met Val 
            20                  25                  30          


Ile Asp Asn Pro Asp Asp Lys Lys Lys Ser Pro Phe Ala Tyr Asn Arg 
        35                  40                  45              


Glu Ile Asn Gln Lys Ile Val Leu Trp Ser Gly Asp Ile Thr Ala Leu 
    50                  55                  60                  


Asp Thr Glu Ala Ile Leu His Ser Thr Asn Glu Thr Leu Ser Asp Val 
65                  70                  75                  80  


Tyr Pro Ala Ser Glu Arg Leu Leu Lys Arg Ala Gly Pro Asp Leu Gln 
                85                  90                  95      


Lys Asp Leu Ser Ser Asn Val Lys Val Cys Arg Thr Gly Glu Ala Arg 
            100                 105                 110         


Leu Thr Lys Gly Tyr Gln Leu Pro Ala Arg Tyr Val Ile His Thr Val 
        115                 120                 125             


Gly Pro Arg Tyr Asn Leu Lys Tyr Lys Thr Ala Ala Glu Ser Ala Leu 
    130                 135                 140                 


Phe Asn Ser Tyr Arg Ser Val Leu Gln Ile Val Arg Glu Lys Gln Met 
145                 150                 155                 160 


Ser Ser Val Ala Leu Cys Cys Ile His Ala Ser Arg Arg Gly Tyr Pro 
                165                 170                 175     


Pro Gln Glu Gly Ala His Ile Ala Leu Arg Thr Val Arg Arg Phe Leu 
            180                 185                 190         


Glu Lys Tyr Gly Asp Thr Ile Asp Thr Val Val Phe Val Val Thr Gly 
        195                 200                 205             


Glu Asp Glu Asp Val Tyr Ile Ser Leu Leu Pro Leu Tyr Phe Pro Arg 
    210                 215                 220                 


Ser Glu His Glu Glu Asp Phe Ala Ala Tyr Gln Leu Pro Asp Asp Val 
225                 230                 235                 240 


Gly Asn Glu Asp Gly Glu Pro Val Ile Lys Glu Arg Gln Ile Arg Ile 
                245                 250                 255     


Met Gly Lys Pro Ala Tyr Glu Ala Gln Lys Phe Asn Trp Lys Ser Pro 
            260                 265                 270         


Glu Glu Leu Glu Glu Ser Ile Asn Ile Asn Glu Ala Phe Asp Thr Ser 
        275                 280                 285             


Ile Ala Val Gly Ala His Ser Phe Ser Lys Met Asp Asp Asp Ile Asp 
    290                 295                 300                 


Lys Lys Arg Arg Ile Arg Leu Gln Tyr Glu Thr His Ile Ala Leu Leu 
305                 310                 315                 320 


Asn Lys Glu Gln Tyr Lys Arg Tyr Glu Lys Trp Leu Lys Arg Ser Tyr 
                325                 330                 335     


Gln Glu Asp Leu Ser Pro Met Glu Ser Leu Arg Cys Leu Tyr Gln Ser 
            340                 345                 350         


Gly Phe Asp Val Tyr Gly Arg Pro Val Val Val Phe Ile Gly Arg His 
        355                 360                 365             


Phe Pro Ala Thr Lys Ile Asp Leu Asp Lys Phe Thr Leu Tyr Leu Val 
    370                 375                 380                 


Gln Leu Met Asp Asn Ile Val Asn Lys Pro Tyr Val Ile Val Tyr Phe 
385                 390                 395                 400 


His Thr Leu Thr Gln Ser Asp Asn His Leu Asp Ala Gly Tyr Leu Arg 
                405                 410                 415     


Ser Leu Tyr Asn Leu Leu Asp Ser Arg Tyr Lys Gln Asn Leu Gly Ala 
            420                 425                 430         


Val Tyr Val Val His Pro Thr Phe Trp Ser Lys Val Met Thr Trp Phe 
        435                 440                 445             


Phe Met Thr Phe Asn Thr Thr Asp Leu Lys Ser Arg Ile His Asn Ile 
    450                 455                 460                 


Pro Gly Leu Glu Tyr Leu Phe Lys Arg Ile Pro Met Asp Gln Leu Asp 
465                 470                 475                 480 


Ile Pro Asp Phe Ile Ser Asp Tyr Asp Ile Gln Val His Gly Thr Arg 
                485                 490                 495     


Tyr Tyr Asn Pro Asp Val Asp Lys Asn Leu 
            500                 505     


<210>  3
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  3

Met His His His His His His Leu Glu Val Leu Phe Gln Gly Pro Val 
1               5                   10                  15      


Asn Ser Phe Ser Gly Tyr Leu Lys Leu Thr Asp Asn Val Tyr Ile Lys 
            20                  25                  30          


Asn Ala Asp Ile Val Glu Glu Ala Lys Lys Val Lys Pro Thr Val Val 
        35                  40                  45              


Val Asn Ala Ala Asn Val Tyr Leu Lys His Gly Gly Gly Val Ala Gly 
    50                  55                  60                  


Ala Leu Asn Lys Ala Thr Asn Asn Ala Met Gln Val Glu Ser Asp Asp 
65                  70                  75                  80  


Tyr Ile Ala Thr Asn Gly Pro Leu Lys Val Gly Gly Ser Cys Val Leu 
                85                  90                  95      


Ser Gly His Asn Leu Ala Lys His Cys Leu His Val Val Gly Pro Asn 
            100                 105                 110         


Val Asn Lys Gly Glu Asp Ile Gln Leu Leu Lys Ser Ala Tyr Glu Asn 
        115                 120                 125             


Phe Asn Gln His Glu Val Leu Leu Ala Pro Leu Leu Ser Ala Gly Ile 
    130                 135                 140                 


Phe Gly Ala Asp Pro Ile His Ser Leu Arg Val Cys Val Asp Thr Val 
145                 150                 155                 160 


Arg Thr Asn Val Tyr Leu Ala Val Phe Asp Lys Asn Leu Tyr Asp Lys 
                165                 170                 175     


Leu Val Ser Ser Phe Leu 
            180         


