<110>南湖实验室 中国人民解放军军事科学院军事医学研究院

<120>没食子儿茶素没食子酸酯及其衍生物的医药用途


<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  825
<212>  PRT
<213> Artificial sequence

<400>  1

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp 
                805                 810                 815     


Lys Asp Tyr Lys Asp Asp Asp Asp Lys 
            820                 825 


<210>  2
<211>  2475
<212>  DNA
<213>  Artificial sequence
<400>  2
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagaccaaag catcaaagtg     1860

aggataagcc taaaatcagc tcttggagat aaagcatatg aatggaacga caatgaaatg     1920

tacctgttcc gatcatctgt tgcatatgct atgaggcagt actttttaaa agtaaaaaat     1980

cagatgattc tttttgggga ggaggatgtg cgagtggcta atttgaaacc aagaatctcc     2040

tttaatttct ttgtcactgc acctaaaaat gtgtctgata tcattcctag aactgaagtt     2100

gaaaaggcca tcaggatgtc ccggagccgt atcaatgatg ctttccgtct gaatgacaac     2160

agcctagagt ttctggggat acagccaaca cttggacctc ctaaccagcc ccctgtttcc     2220

atatggctga ttgtttttgg agttgtgatg ggagtgatag tggttggcat tgtcatcctg     2280

atcttcactg ggatcagaga tcggaagaag aaaaataaag caagaagtgg agaaaatcct     2340

tatgcctcca tcgatattag caaaggagaa aataatccag gattccaaaa cactgatgat     2400

gttcagacct cctttggagg aggaagcgat tacaaggatg acgacgataa ggattacaag     2460

gatgacgacg ataag                                                      2475


<210>  3
<211>  8614
<212>  DNA
<213> Artificial sequence
<400>  3
tggaagggct aattcactcc caaagaagac aagatatcct tgatctgtgg atctaccaca       60

cacaaggcta cttccctgat tagcagaact acacaccagg gccaggggtc agatatccac      120

tgacctttgg atggtgctac aagctagtac cagttgagcc agataaggta gaagaggcca      180

ataaaggaga gaacaccagc ttgttacacc ctgtgagcct gcatgggatg gatgacccgg      240

agagagaagt gttagagtgg aggtttgaca gccgcctagc atttcatcac gtggcccgag      300

agctgcatcc ggagtacttc aagaactgct gatatcgagc ttgctacaag ggactttccg      360

ctggggactt tccagggagg cgtggcctgg gcgggactgg ggagtggcga gccctcagat      420

cctgcatata agcagctgct ttttgcctgt actgggtctc tctggttaga ccagatctga      480

gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct      540

tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc      600

agaccctttt agtcagtgtg gaaaatctct agcagtggcg cccgaacagg gacttgaaag      660

cgaaagggaa accagaggag ctctctcgac gcaggactcg gcttgctgaa gcgcgcacgg      720

caagaggcga ggggcggcga ctggtgagta cgccaaaaat tttgactagc ggaggctaga      780

aggagagaga tgggtgcgag agcgtcagta ttaagcgggg gagaattaga tcgcgatggg      840

aaaaaattcg gttaaggcca gggggaaaga aaaaatataa attaaaacat atagtatggg      900

caagcaggga gctagaacga ttcgcagtta atcctggcct gttagaaaca tcagaaggct      960

gtagacaaat actgggacag ctacaaccat cccttcagac aggatcagaa gaacttagat     1020

cattatataa tacagtagca accctctatt gtgtgcatca aaggatagag ataaaagaca     1080

ccaaggaagc tttagacaag atagaggaag agcaaaacaa aagtaagacc accgcacagc     1140

aagcggccgg ccgctgatct tcagacctgg aggaggagat atgagggaca attggagaag     1200

tgaattatat aaatataaag tagtaaaaat tgaaccatta ggagtagcac ccaccaaggc     1260

aaagagaaga gtggtgcaga gagaaaaaag agcagtggga ataggagctt tgttccttgg     1320

gttcttggga gcagcaggaa gcactatggg cgcagcgtca atgacgctga cggtacaggc     1380

cagacaatta ttgtctggta tagtgcagca gcagaacaat ttgctgaggg ctattgaggc     1440

gcaacagcat ctgttgcaac tcacagtctg gggcatcaag cagctccagg caagaatcct     1500

ggctgtggaa agatacctaa aggatcaaca gctcctgggg atttggggtt gctctggaaa     1560

actcatttgc accactgctg tgccttggaa tgctagttgg agtaataaat ctctggaaca     1620

gatttggaat cacacgacct ggatggagtg ggacagagaa attaacaatt acacaagctt     1680

aatacactcc ttaattgaag aatcgcaaaa ccagcaagaa aagaatgaac aagaattatt     1740

ggaattagat aaatgggcaa gtttgtggaa ttggtttaac ataacaaatt ggctgtggta     1800

tataaaatta ttcataatga tagtaggagg cttggtaggt ttaagaatag tttttgctgt     1860

actttctata gtgaatagag ttaggcaggg atattcacca ttatcgtttc agacccacct     1920

cccaaccccg aggggacccg acaggcccga aggaatagaa gaagaaggtg gagagagaga     1980

cagagacaga tccattcgat tagtgaacgg atctcgacgg tatcgccttt aaaagaaaag     2040

gggggattgg ggggtacagt gcaggggaaa gaatagtaga cataatagca acagacatac     2100

aaactaaaga actacaaaaa caaattacaa aaattcaaaa ttttcgggtt tattacaggg     2160

acagcagaga tccagtttat cgatgaggcc ctttcgtctt cactcgaggt gcccgtcagt     2220

gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa     2280

ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc     2340

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc     2400

tttttcgcaa cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt tcccgcgggc     2460

ctggcctctt tacgggttat ggcccttgcg tgccttgaat tacttccacc tggctgcagt     2520

acgtgattct tgatcccgag cttcgggttg gaagtgggtg ggagagttcg aggccttgcg     2580

cttaaggagc cccttcgcct cgtgcttgag ttgaggcctg gcctgggcgc tggggccgcc     2640

gcgtgcgaat ctggtggcac cttcgcgcct gtctcgctgc tttcgataag tctctagcca     2700

tttaaaattt ttgatgacct gctgcgacgc tttttttctg gcaagatagt cttgtaaatg     2760

cgggccaaga tctgcacact ggtatttcgg tttttggggc cgcgggcggc gacggggccc     2820

gtgcgtccca gcgcacatgt tcggcgaggc ggggcctgcg agcgcggcca ccgagaatcg     2880

gacgggggta gtctcaagct ggccggcctg ctctggtgcc tggcctcgcg ccgccgtgta     2940

tcgccccgcc ctgggcggca aggctggccc ggtcggcacc agttgcgtga gcggaaagat     3000

ggccgcttcc cggccctgct gcagggagct caaaatggag gacgcggcgc tcgggagagc     3060

gggcgggtga gtcacccaca caaaggaaaa gggcctttcc gtcctcagcc gtcgcttcat     3120

gtgactccac ggagtaccgg gcgccgtcca ggcacctcga ttagttctcg agcttttgga     3180

gtacgtcgtc tttaggttgg ggggaggggt tttatgcgat ggagtttccc cacactgagt     3240

gggtggagac tgaagttagg ccagcttggc acttgatgta attctccttg gaatttgccc     3300

tttttgagtt tggatcttgg ttcattctca agcctcagac agtggttcaa agtttttttc     3360

ttccatttca ggtgtcgtga ggatccgcgg ccgcgccggc tctagatcgc gaacgcgtga     3420

attcctcgag ggcggccgct ctagagtcga cgggccgcgg taacaattgt taactaactt     3480

aagctagcaa cggtttccct ctagcgggat caattccgcc ccccccccct aacgttactg     3540

gccgaagccg cttggaataa ggccggtgtg cgtttgtcta tatgttattt tccaccatat     3600

tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc     3660

ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag     3720

cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc     3780

ggaacccccc acctggcgac aggtgcctct gcggccaaaa gccacgtgta taagatacac     3840

ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca     3900

aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt     3960

gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa     4020

aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat     4080

accatggtca tgaaaacatt taacatttct caacaagatc tagaattagt agaagtagcg     4140

acagagaaga ttacaatgct ttatgaggat aataaacatc atgtgggagc ggcaattcgt     4200

acgaaaacag gagaaatcat ttcggcagta catattgaag cgtatatagg acgagtaact     4260

gtttgtgcag aagccattgc gattggtagt gcagtttcga atggacaaaa ggattttgac     4320

acgattgtag ctgttagaca cccttattct gacgaagtag atagaagtat tcgagtggta     4380

agtccttgtg gtatgtgtag ggagttgatt tcagactatg caccagattg ttttgtgtta     4440

atagaaatga atggcaagtt agtcaaaact acgattgaag aactcattcc actcaaatat     4500

acccgaaatt aacccgggcg gggcgcgtct ggaacaatca acctctggat tacaaaattt     4560

gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg     4620

ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt     4680

ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg     4740

tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc     4800

agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg     4860

cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt     4920

tgtcggggaa gctgacgtcc tttccatggc tgctcgcctg tgttgccacc tggattctgc     4980

gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg     5040

gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga     5100

tctccctttg ggccgcctcc ccgcctggaa ttaattctgc agtcgagacc tagaaaaaca     5160

tggagcaatc acaagtagca atacagcagc taccaatgct gattgtgcct ggctagaagc     5220

acaagaggag gaggaggtgg gtttttccag tcacacctca ggtaccttta agaccaatga     5280

cttacaaggc agctgtagat cttagccact ttttaaaaga aaagagggga ctggaagggc     5340

taattcactc ccaacgaaga caagatatcc ttgatctgtg gatctaccac acacaaggct     5400

acttccctga ttagcagaac tacacaccag ggccaggggt cagatatcca ctgacctttg     5460

gatggtgcta caagctagta ccagttgagc cagataaggt agaagaggcc aataaaggag     5520

agaacaccag cttgttacac cctgtgagcc tgcatgggat ggatgacccg gagagagaag     5580

tgttagagtg gaggtttgac agccgcctag catttcatca cgtggcccga gagctgcatc     5640

cggagtactt caagaactgc tgatatcgag cttgctacaa gggactttcc gctggggact     5700

ttccagggag gcgtggcctg ggcgggactg gggagtggcg agccctcaga tcctgcatat     5760

aagcagctgc tttttgcctg tactgggtct ctctggttag accagatctg agcctgggag     5820

ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc ttgagtgctt     5880

caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct cagacccttt     5940

tagtcagtgt ggaaaatctc tagcagtagt agttcatgtc atcttattat tcagtattta     6000

taacttgcaa agaaatgaat atcagagagt gagaggcctt gacattgcta gcgttttacc     6060

gtcgacctct agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg     6120

ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg     6180

tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc     6240

gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt     6300

gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct     6360

gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga     6420

taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc     6480

cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg     6540

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg     6600

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt     6660

tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt     6720

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg     6780

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact     6840

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt     6900

cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct     6960

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac     7020

cgctggtagc ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca     7080

agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta     7140

agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa     7200

atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg     7260

cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg     7320

actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc     7380

aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc     7440

cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa     7500

ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc     7560

cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7620

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7680

cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat     7740

ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg     7800

tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc     7860

ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg     7920

aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat     7980

gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg     8040

gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg     8100

ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct     8160

catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac     8220

atttccccga aaagtgccac ctgacgtcga cggatcggga gatcaacttg tttattgcag     8280

cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt     8340

cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatca     8400

actggataac tcaagctaac caaaatcatc ccaaacttcc caccccatac cctattacca     8460

ctgccaatta cctagtggtt tcatttactc taaacctgtg attcctctga attattttca     8520

ttttaaagaa attgtatttg ttaaatatgt actacaaact tagtagtttt taaagaaatt     8580

gtatttgtta aatatgtact acaaacttag tagt                                 8614


<210>  4
<211>  680
<212>  PRT
<213>  Artificial sequence
<400>  4

Met Asp Tyr Lys Asp Asp Asp Asp Lys Ser Asp Asn Gly Pro Gln Asn 
1               5                   10                  15      


Gln Arg Asn Ala Pro Arg Ile Thr Phe Gly Gly Pro Ser Asp Ser Thr 
            20                  25                  30          


Gly Ser Asn Gln Asn Gly Glu Arg Ser Gly Ala Arg Ser Lys Gln Arg 
        35                  40                  45              


Arg Pro Gln Gly Leu Pro Asn Asn Thr Ala Ser Trp Phe Thr Ala Leu 
    50                  55                  60                  


Thr Gln His Gly Lys Glu Asp Leu Lys Phe Pro Arg Gly Gln Gly Val 
65                  70                  75                  80  


Pro Ile Asn Thr Asn Ser Ser Pro Asp Asp Gln Ile Gly Tyr Tyr Arg 
                85                  90                  95      


Arg Ala Thr Arg Arg Ile Arg Gly Gly Asp Gly Lys Met Lys Asp Leu 
            100                 105                 110         


Ser Pro Arg Trp Tyr Phe Tyr Tyr Leu Gly Thr Gly Pro Glu Ala Gly 
        115                 120                 125             


Leu Pro Tyr Gly Ala Asn Lys Asp Gly Ile Ile Trp Val Ala Thr Glu 
    130                 135                 140                 


Gly Ala Leu Asn Thr Pro Lys Asp His Ile Gly Thr Arg Asn Pro Ala 
145                 150                 155                 160 


Asn Asn Ala Ala Ile Val Leu Gln Leu Pro Gln Gly Thr Thr Leu Pro 
                165                 170                 175     


Lys Gly Phe Tyr Ala Glu Gly Ser Arg Gly Gly Ser Gln Ala Ser Ser 
            180                 185                 190         


Arg Ser Ser Ser Arg Ser Arg Asn Ser Ser Arg Asn Ser Thr Pro Gly 
        195                 200                 205             


Ser Ser Arg Gly Thr Ser Pro Ala Arg Met Ala Gly Asn Gly Gly Asp 
    210                 215                 220                 


Ala Ala Leu Ala Leu Leu Leu Leu Asp Arg Leu Asn Gln Leu Glu Ser 
225                 230                 235                 240 


Lys Met Ser Gly Lys Gly Gln Gln Gln Gln Gly Gln Thr Val Thr Lys 
                245                 250                 255     


Lys Ser Ala Ala Glu Ala Ser Lys Lys Pro Arg Gln Lys Arg Thr Ala 
            260                 265                 270         


Thr Lys Ala Tyr Asn Val Thr Gln Ala Phe Gly Arg Arg Gly Pro Glu 
        275                 280                 285             


Gln Thr Gln Gly Asn Phe Gly Asp Gln Glu Leu Ile Arg Gln Gly Thr 
    290                 295                 300                 


Asp Tyr Lys His Trp Pro Gln Ile Ala Gln Phe Ala Pro Ser Ala Ser 
305                 310                 315                 320 


Ala Phe Phe Gly Met Ser Arg Ile Gly Met Glu Val Thr Pro Ser Gly 
                325                 330                 335     


Thr Trp Leu Thr Tyr Thr Gly Ala Ile Lys Leu Asp Asp Lys Asp Pro 
            340                 345                 350         


Asn Phe Lys Asp Gln Val Ile Leu Leu Asn Lys His Ile Asp Ala Tyr 
        355                 360                 365             


Lys Thr Phe Pro Pro Thr Glu Pro Lys Lys Asp Lys Lys Lys Lys Ala 
    370                 375                 380                 


Asp Glu Thr Gln Ala Leu Pro Gln Arg Gln Lys Lys Gln Gln Thr Val 
385                 390                 395                 400 


Thr Leu Leu Pro Ala Ala Asp Leu Asp Asp Phe Ser Lys Gln Leu Gln 
                405                 410                 415     


Gln Ser Met Ser Ser Ala Asp Ser Thr Gln Ala Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Ser Lys Gly Glu Glu 
        435                 440                 445             


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
    450                 455                 460                 


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
465                 470                 475                 480 


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
                485                 490                 495     


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys 
            500                 505                 510         


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
        515                 520                 525             


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
    530                 535                 540                 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
545                 550                 555                 560 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                565                 570                 575     


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
            580                 585                 590         


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
        595                 600                 605             


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
    610                 615                 620                 


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
625                 630                 635                 640 


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
                645                 650                 655     


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
            660                 665                 670         


Leu Gly Met Asp Glu Leu Tyr Lys 
        675                 680 


<210>  5
<211>  2043
<212>  DNA
<213>  Artificial sequence

<400>  5
atggactaca aggacgacga tgacaagtct gataatggac cccaaaatca gcgaaatgca       60

ccccgcatta cgtttggtgg accctcagat tcaactggca gtaaccagaa tggagaacgc      120

agtggggcgc gatcaaaaca acgtcggccc caaggtttac ccaataatac tgcgtcttgg      180

ttcaccgctc tcactcaaca tggcaaggaa gaccttaaat tccctcgagg acaaggcgtt      240

ccaattaaca ccaatagcag tccagatgac caaattggct actaccgaag agctaccaga      300

cgaattcgtg gtggtgacgg taaaatgaaa gatctcagtc caagatggta tttctactac      360

ctaggaactg ggccagaagc tggacttccc tatggtgcta acaaagacgg catcatatgg      420

gttgcaactg agggagcctt gaatacacca aaagatcaca ttggcacccg caatcctgct      480

aacaatgctg caatcgtgct acaacttcct caaggaacaa cattgccaaa aggcttctac      540

gcagaaggga gcagaggcgg cagtcaagcc tcttctcgtt cctcatcacg tagtcgcaac      600

agttcaagaa attcaactcc aggcagcagt aggggaactt ctcctgctag aatggctggc      660

aatggcggtg atgctgctct tgctttgctg ctgcttgaca gattgaacca gcttgagagc      720

aaaatgtctg gtaaaggcca acaacaacaa ggccaaactg tcactaagaa atctgctgct      780

gaggcttcta agaagcctcg gcaaaaacgt actgccacta aagcatacaa tgtaacacaa      840

gctttcggca gacgtggtcc agaacaaacc caaggaaatt ttggggacca ggaactaatc      900

agacaaggaa ctgattacaa acattggccg caaattgcac aatttgcccc cagcgcttca      960

gcgttcttcg gaatgtcgcg cattggcatg gaagtcacac cttcgggaac gtggttgacc     1020

tacacaggtg ccatcaaatt ggatgacaaa gatccaaatt tcaaagatca agtcattttg     1080

ctgaataagc atattgacgc atacaaaaca ttcccaccaa cagagcctaa aaaggacaaa     1140

aagaagaagg ctgatgaaac tcaagcctta ccgcagagac agaagaaaca gcaaactgtg     1200

actcttcttc ctgctgcaga tttggatgat ttctccaaac aattgcaaca atccatgagc     1260

agtgctgact caactcaggc cggtggagga ggttctggag gcggtggaag tggtggcgga     1320

ggtagcgtga gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg     1380

gacggcgacg taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc     1440

tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc     1500

accctcgtga ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg     1560

aagcagcacg acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc     1620

ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc     1680

ctggtgaacc gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg     1740

cacaagctgg agtacaacta caacagccac aacgtctata tcatggccga caagcagaag     1800

aacggcatca aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc     1860

gccgaccact accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac     1920

cactacctga gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg     1980

gtcctgctgg agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag     2040

tga                                                                   2043
