                         SEQUENCE LISTING

<110>  University College Cardiff Consultants Limited
 
<120>  Anti-Viral Therapeutic

<130>  0310P/WO

<150>  GB2101066.5
<151>  2021-01-27

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable region D3

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Met Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  2
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region G3

<400>  2

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Ala Tyr 
            20                  25                  30          


Asn Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Asp Asn Arg Pro Ser Gly Val Ser Thr Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Pro Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Arg 
                85                  90                  95      


Arg Thr Leu Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  3
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region G4

<400>  3

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ala Ser Ser Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Val Ser Ile Arg Ala Asn Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Tyr Cys Gln His Arg Asn Asn Trp Gly Ser 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region G11

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Lys Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Leu Lys Ser Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Asp Leu Gln Ser Gly Val Pro Thr Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Arg Gly Leu Gln Ser 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asp His Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  5
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region B2

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Gly Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Met Ala Ser Ser Leu Glu Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  6
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region C3

<400>  6

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Leu Glu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  7
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region E5

<400>  7

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Ile Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Ala Ile Arg Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Phe Cys Ala Ala Arg Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  8
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region G2

<400>  8

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ile Gly Thr Ser Ser Asp Val Gly Lys Asn 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln Tyr Pro Asp Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Met Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala His Tyr Tyr Cys Cys Ser Tyr Ala Gly Val 
                85                  90                  95      


Gly Gly His Ile Leu Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu 
    


<210>  9
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region D3

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile His Ser Asp Gly Pro Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Met Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Glu Phe Ala Ser Gly Leu Tyr Gly Ser Ala Gly Ser Asn Ala 
            100                 105                 110         


Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  10
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region G3

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Thr Phe Thr Ile Ser Pro Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Asp Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Pro Asp Ala Phe Ser Thr Gly Trp Ser Asn Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Met Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  11
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region G4

<400>  11

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Ser Gly 
            20                  25                  30          


Ser Tyr Tyr Trp Thr Trp Ile Arg Gln Pro Ala Gly Glu Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Ile Asn Thr Arg Gly Asn Ile Asn Tyr Lys Pro Ser 
    50                  55                  60                  


Leu Arg Ser Arg Leu Thr Phe Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Gln Leu Ser Ser Val Thr Ala Ala Asp Ser Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Val Gly Leu Tyr Asp Thr Tyr Tyr Tyr Phe Met Asp Val 
            100                 105                 110         


Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  12
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region G11

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Val Ser Ala Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg His Ser Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Phe Asn Gly Lys Phe Asn Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Gly Pro Ser Lys Thr Gln Leu Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ile Gly Asp Ser Thr Met Ala Pro Leu Tyr Tyr Phe Tyr Tyr Ile 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  13
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region B2

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Phe Thr Val Ser Ser Met 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Asp Gly Thr Thr Tyr Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Lys Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Glu Phe Ala Ser Gly Trp Tyr Gly Ser Ala Gly Ser Asn Ala 
            100                 105                 110         


Phe Asp Ile Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  14
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region C3

<400>  14

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Thr Met Val Arg Gly Val Ile Tyr Asn Lys Arg Pro 
            100                 105                 110         


Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  15
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region E5

<400>  15

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Met Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Val 
        35                  40                  45              


Gly Gly Ile Val Pro Phe Leu Gly Lys Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ser Thr Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Pro Pro Pro Val Met Val Arg Gly Ile His Arg Thr Gly 
            100                 105                 110         


Gly Asp Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  16
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UL141 variable region G2

<400>  16

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Phe His 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Ser Asp Thr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


His Ser Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ser Tyr 
65                  70                  75                  80  


Met Gln Leu Thr Ser Leu Thr Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Pro Val Ala Thr Gly Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  17
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD16 primer

<400>  17
gggggaccgg acgtcttcct cttcccccca                                        30


<210>  18
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD16 primer

<400>  18
ggttttctcc tcgggggctg ggaggg                                            26


<210>  19
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD16 primer

<400>  19

Ala Gly Gly Ala Ala Gly Ala Cys Gly Thr Cys Cys Gly Gly Thr Cys 
1               5                   10                  15      


Cys Cys Cys Cys Cys Ala Gly Gly Ala Gly 
            20                  25      


<210>  20
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD16 primer

<400>  20
cagcccccga ggagaaaacc atctccaaag cca                                    33


<210>  21
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UL119 F primer

<400>  21
gagctggtcg ccctgatgca gatgcacggt gctgttgggg ttgccgtgtg acgagacggc       60

gtgtggacga gctatatgtt agggataaca gggtaatggc                            100


<210>  22
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UL119 R primer

<400>  22
gtttaggcgt cacaagaggt gacgcgacct cctgccacat atagctcgtc cacacgccgt       60

ctcgtcacac ggcaactcag aagaactcgt caagaaggcg                            100


<210>  23
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RL11-12-F primer

<400>  23
acgacgtctg ataaggaagg cgagaacgtc ttttgcaccg cactatcaca aataataaca       60

tgcgcaaaac aagtcaccgt agggataaca gggtaatggc                            100


<210>  24
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RL11-12-R primer

<400>  24
agagcccatg tagtgcgcgt gccatgtgag atgtcacggt gacttgtttt gcgcatgtta       60

ttatttgtga tagtgctcag aagaactcgt caagaaggcg                            100


<210>  25
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UL16 F primer

<400>  25
tggggtcaaa agcctgggta cttatgggga gcgcgcacaa aggaccgtca ggcgccggca       60

ataatcgagc gcctctacgt agggataaca gggtaatggc                            100


<210>  26
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UL16 R Primer

<400>  26
atccgggcgg tctcggatat agcgagccca atcggacgta gaggcgctcg attattgccg       60

gcgcctgacg gtcctttcag aagaactcgt caagaaggcg                            100


<210>  27
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UL141 F Primer

<400>  27
gtgaaaatac tccaaaatcc caaaaatgcc gcgattcccc gagtggccca gggagagatg       60

attcttttct tccctttagg gataacaggg taatcgattt                            100


<210>  28
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UL141 R Primer

<400>  28
cacggagcag gaacaggcgg gcagcgtctc tgcgaaaaag ggaagaaaag aatcatctct       60

ccctgggcca ctcgggggcc agtgttacaa ccaattaacc                            100


<210>  29
<211>  338
<212>  PRT
<213>  Human cytomegalovirus

<400>  29

Met Cys Arg Arg Glu Ser Leu Arg Thr Leu Pro Trp Leu Phe Trp Val 
1               5                   10                  15      


Leu Leu Ser Cys Pro Arg Leu Leu Glu Tyr Ser Ser Ser Ser Phe Pro 
            20                  25                  30          


Phe Ala Thr Ala Asp Ile Ala Glu Lys Met Trp Ala Glu Asn Tyr Glu 
        35                  40                  45              


Thr Thr Ser Pro Ala Pro Val Leu Val Ala Glu Gly Glu Gln Val Thr 
    50                  55                  60                  


Ile Pro Cys Thr Val Met Thr His Ser Trp Pro Met Val Ser Ile Arg 
65                  70                  75                  80  


Ala Arg Phe Cys Arg Ser His Asp Gly Ser Asp Glu Leu Ile Leu Asp 
                85                  90                  95      


Ala Val Lys Gly His Arg Leu Met Asn Gly Leu Gln Tyr Arg Leu Pro 
            100                 105                 110         


Tyr Ala Thr Trp Asn Phe Ser Gln Leu His Leu Gly Gln Ile Phe Ser 
        115                 120                 125             


Leu Thr Phe Asn Val Ser Thr Asp Thr Ala Gly Met Tyr Glu Cys Val 
    130                 135                 140                 


Leu Arg Asn Tyr Ser His Gly Leu Ile Met Gln Arg Phe Val Ile Leu 
145                 150                 155                 160 


Thr Gln Leu Glu Thr Leu Ser Arg Pro Asp Glu Pro Cys Cys Thr Pro 
                165                 170                 175     


Ala Leu Gly Arg Tyr Ser Leu Gly Asp Gln Ile Trp Ser Pro Thr Pro 
            180                 185                 190         


Trp Arg Leu Arg Asn His Asp Cys Gly Met Tyr Arg Gly Phe Gln Arg 
        195                 200                 205             


Asn Tyr Phe Tyr Ile Gly Arg Ala Asp Ala Glu Asp Cys Trp Lys Pro 
    210                 215                 220                 


Ala Cys Pro Asp Glu Glu Pro Asp Arg Cys Trp Thr Val Ile Gln Arg 
225                 230                 235                 240 


Tyr Arg Leu Pro Gly Asp Cys Tyr Arg Ser Gln Pro His Pro Pro Lys 
                245                 250                 255     


Phe Leu Pro Val Thr Pro Ala Pro Pro Ala Asp Ile Asp Thr Gly Met 
            260                 265                 270         


Ser Pro Trp Ala Thr Arg Gly Ile Ala Ala Phe Leu Gly Phe Trp Ser 
        275                 280                 285             


Ile Phe Thr Val Cys Phe Leu Cys Tyr Leu Cys Tyr Leu Gln Cys Cys 
    290                 295                 300                 


Gly Arg Trp Cys Pro Thr Pro Gly Arg Gly Arg Arg Gly Gly Glu Gly 
305                 310                 315                 320 


Tyr Arg Arg Leu Pro Thr Tyr Asp Ser Tyr Pro Gly Val Lys Lys Met 
                325                 330                 335     


Lys Arg 
        


<210>  30
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  31
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD16 variable region

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Leu Glu Ala Val 
        35                  40                  45              


Ala Ser Ile Thr Trp Ser Gly Arg Asp Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Pro Trp Pro Val Ala Ala Pro Arg Ser Gly Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  32
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD16 Variable region

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
    130                 135                 140                 


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser 
145                 150                 155                 160 


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
                165                 170                 175     


Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe 
            180                 185                 190         


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
        195                 200                 205             


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser 
    210                 215                 220                 


Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 


<210>  33
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD16 variable region

<400>  33

Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val Leu 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly Ser 
            100                 105                 110         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser 
    130                 135                 140                 


Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Ala Ile Glu Pro Met Tyr Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
            180                 185                 190         


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  34
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  34

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  35
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  35

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  36
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  37
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA variable region

<400>  37

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  38
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA variable region

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile 
                85                  90                  95      


Ser Asp Thr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


