                         SEQUENCE LISTING

<110>  Immunis, Inc.
 
<120>  MOLECULAR SUPERSTRUCTURE AND METHODS OF USE THEREOF

<130>  IMBIO.001.WO

<140>  PCT/US2022/013706
<141>  2022-01-25

<150>  63/141,977
<151>  2021-01-26

<150>  63/191,839
<151>  2021-05-22

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A isoform 1

<400>  1

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile 
    50                  55                  60                  


Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala 
65                  70                  75                  80  


Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys 
                85                  90                  95      


Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala 
            100                 105                 110         


Lys Cys Asp Ser Ser Pro Ala Asp Ser Ala Glu Asp Val Arg Lys Val 
        115                 120                 125             


Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val 
    130                 135                 140                 


His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly 
145                 150                 155                 160 


Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu 
                165                 170                 175     


Pro Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val 
            180                 185                 190         


Ala Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys 
        195                 200                 205             


Gln Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly Ala 
    210                 215                 220                 


Glu Val Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser Ser 
225                 230                 235                 240 


Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val Val 
                245                 250                 255     


Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu Pro 
            260                 265                 270         


Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro Pro 
        275                 280                 285             


Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr Phe Met 
    290                 295                 300                 


Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro Arg 
305                 310                 315                 320 


Lys Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly Pro 
                325                 330                 335     


Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
            340                 345                 350 


<210>  2
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A isoform 2

<400>  2

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile 
    50                  55                  60                  


Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala 
65                  70                  75                  80  


Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys 
                85                  90                  95      


Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala 
            100                 105                 110         


Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys Val Cys 
        115                 120                 125             


Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val His 
    130                 135                 140                 


Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly Ser 
145                 150                 155                 160 


Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu Pro 
                165                 170                 175     


Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val Ala 
            180                 185                 190         


Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys Gln 
        195                 200                 205             


Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly Ala Glu 
    210                 215                 220                 


Val Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser Ser Gln 
225                 230                 235                 240 


Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val Val Asp 
                245                 250                 255     


Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu Pro Pro 
            260                 265                 270         


Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro Pro Gly 
        275                 280                 285             


His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr Phe Met Gly 
    290                 295                 300                 


Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro Arg Lys 
305                 310                 315                 320 


Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly Pro Val 
                325                 330                 335     


Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
            340                 345                 


<210>  3
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A isoform 3

<400>  3

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile Asp 
    50                  55                  60                  


Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala Arg 
65                  70                  75                  80  


Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys Asp 
                85                  90                  95      


Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala Lys 
            100                 105                 110         


Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys Val Cys Gln 
        115                 120                 125             


Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val His Ala 
    130                 135                 140                 


Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly Ser Asn 
145                 150                 155                 160 


Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu Pro Pro 
                165                 170                 175     


Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val Ala Lys 
            180                 185                 190         


Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys Gln Tyr 
        195                 200                 205             


Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly Ala Glu Val 
    210                 215                 220                 


Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser Ser Gln Pro 
225                 230                 235                 240 


Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val Val Asp Pro 
                245                 250                 255     


Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu Pro Pro Ala 
            260                 265                 270         


Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro Pro Gly His 
        275                 280                 285             


Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr Phe Met Gly Val 
    290                 295                 300                 


Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro Arg Lys Thr 
305                 310                 315                 320 


Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly Pro Val Val 
                325                 330                 335     


Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
            340                 345             


<210>  4
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A isoform 4

<400>  4

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile 
    50                  55                  60                  


Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala 
65                  70                  75                  80  


Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys 
                85                  90                  95      


Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala 
            100                 105                 110         


Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys Val Cys 
        115                 120                 125             


Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val His 
    130                 135                 140                 


Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly Ser 
145                 150                 155                 160 


Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu Pro 
                165                 170                 175     


Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val Ala 
            180                 185                 190         


Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys Pro 
        195                 200                 205             


Val Ser Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr 
    210                 215                 220                 


Pro Val Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro 
225                 230                 235                 240 


Gly Leu Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala 
                245                 250                 255     


Ala Pro Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His 
            260                 265                 270         


Thr Phe Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser 
        275                 280                 285             


His Pro Arg Lys Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala 
    290                 295                 300                 


Ala Gly Pro Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys 
305                 310                 315                 320 


Val 
    


<210>  5
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A isoform Chain A

<400>  5

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile 
    50                  55                  60                  


Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala 
65                  70                  75                  80  


Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys 
                85                  90                  95      


Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala 
            100                 105                 110         


Lys Cys Asp Ser Ser Pro Ala Asp Ser Ala Glu Asp Val Arg Lys Val 
        115                 120                 125             


Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val 
    130                 135                 140                 


His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly 
145                 150                 155                 160 


Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu 
                165                 170                 175     


Pro Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val 
            180                 185                 190         


Ala Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys 
        195                 200                 205             


Gln Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly Ala 
    210                 215                 220                 


Glu Val Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser Ser 
225                 230                 235                 240 


Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val Val 
                245                 250                 255     


Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu Pro 
            260                 265                 270         


Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu 
        275                 280             


<210>  6
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A isoform linker

<400>  6

Leu Ala Ala Pro Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu 
1               5                   10                  15      


Arg His Thr Phe Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu 
            20                  25                  30          


Val Ser His Pro Arg Lys Thr Arg 
        35                  40  


<210>  7
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A isoform Chain B

<400>  7

Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly Pro Val Val Pro 
1               5                   10                  15      


Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
            20                  25          


<210>  8
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A isoform Chain A

<400>  8

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile 
    50                  55                  60                  


Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala 
65                  70                  75                  80  


Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys 
                85                  90                  95      


Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala 
            100                 105                 110         


Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys Val Cys 
        115                 120                 125             


Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val His 
    130                 135                 140                 


Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly Ser 
145                 150                 155                 160 


Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu Pro 
                165                 170                 175     


Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val Ala 
            180                 185                 190         


Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys Gln 
        195                 200                 205             


Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly Ala Glu 
    210                 215                 220                 


Val Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser Ser Gln 
225                 230                 235                 240 


Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val Val Asp 
                245                 250                 255     


Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu Pro Pro 
            260                 265                 270         


Ala Gly Ser Pro Pro Asp Ser His Val Leu 
        275                 280         


<210>  9
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A isoform Chain A

<400>  9

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile Asp 
    50                  55                  60                  


Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala Arg 
65                  70                  75                  80  


Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys Asp 
                85                  90                  95      


Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala Lys 
            100                 105                 110         


Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys Val Cys Gln 
        115                 120                 125             


Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val His Ala 
    130                 135                 140                 


Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly Ser Asn 
145                 150                 155                 160 


Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu Pro Pro 
                165                 170                 175     


Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val Ala Lys 
            180                 185                 190         


Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys Gln Tyr 
        195                 200                 205             


Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly Ala Glu Val 
    210                 215                 220                 


Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser Ser Gln Pro 
225                 230                 235                 240 


Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val Val Asp Pro 
                245                 250                 255     


Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu Pro Pro Ala 
            260                 265                 270         


Gly Ser Pro Pro Asp Ser His Val Leu 
        275                 280     


<210>  10
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A isoform Chain A

<400>  10

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile 
    50                  55                  60                  


Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala 
65                  70                  75                  80  


Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys 
                85                  90                  95      


Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala 
            100                 105                 110         


Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys Val Cys 
        115                 120                 125             


Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val His 
    130                 135                 140                 


Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly Ser 
145                 150                 155                 160 


Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu Pro 
                165                 170                 175     


Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val Ala 
            180                 185                 190         


Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys Pro 
        195                 200                 205             


Val Ser Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr 
    210                 215                 220                 


Pro Val Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro 
225                 230                 235                 240 


Gly Leu Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu 
                245                 250                 


<210>  11
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FETUA_HUMAN Alpha-2-HS-glycoprotein

<400>  11

Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys 
            20                  25                  30          


Asp Asp Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile 
        35                  40                  45              


Asn Gln Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp 
    50                  55                  60                  


Glu Val Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile 
65                  70                  75                  80  


Glu Ile Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro 
                85                  90                  95      


Val Ala Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly 
            100                 105                 110         


Asp Cys Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val 
        115                 120                 125             


Tyr Ala Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys 
    130                 135                 140                 


Val Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val 
145                 150                 155                 160 


Val His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn 
                165                 170                 175     


Gly Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro 
            180                 185                 190         


Leu Pro Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys 
        195                 200                 205             


Val Ala Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu 
    210                 215                 220                 


Lys Gln Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly 
225                 230                 235                 240 


Ala Glu Val Ala Val Thr Cys Thr Val Phe Gln Thr Gln Pro Val Thr 
                245                 250                 255     


Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val 
            260                 265                 270         


Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu 
        275                 280                 285             


Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro 
    290                 295                 300                 


Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr Phe 
305                 310                 315                 320 


Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro 
                325                 330                 335     


Arg Lys Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly 
            340                 345                 350         


Pro Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
        355                 360                 365         


<210>  12
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-beta binding domain

<400>  12

Cys Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr 
1               5                   10                  15      


Ala Lys Cys 
            


