                         SEQUENCE LISTING

<110>  OUTPACE BIO, INC.
       FOIGHT, GLENNA
       BOYKEN, SCOTT
       LAJOIE, MARC
 
<120>  SMALL MOLECULE-REGULATED CELL SIGNALING EXPRESSION SYSTEM

<130>  OTPC-024/01WO 347008-2132

<140>  PCT/US2022/014624
<141>  2022-01-31

<150>  US 63/143,725
<151>  2021-01-29

<160>  147   

<170>  PatentIn version 3.5

<210>  1
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  NON_CONS
<222>  (20)..(21)
<223>  Residues at these positions can be separated by a scFV_hinge 
       region of unknown length

<400>  1

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val 
            20                  25                  30          


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        35                  40                  45              


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    50                  55                  60                  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
65                  70                  75                  80  


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ala 
                85                  90                  95      


Ser Gly Ser Ala Ser Gly Ser Ala Ser Met Gly Val Gln Val Glu Thr 
            100                 105                 110         


Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys 
        115                 120                 125             


Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser 
    130                 135                 140                 


Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu 
145                 150                 155                 160 


Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln 
                165                 170                 175     


Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly 
            180                 185                 190         


His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu 
        195                 200                 205             


Leu Leu Lys Leu Glu Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
    210                 215                 220                 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ile His Leu Gly 
225                 230                 235                 240 


His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala Ala Ala Gln Thr Thr 
                245                 250                 255     


Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly 
            260                 265                 270         


Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Met Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         


Leu Gly Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Gly Ser Gly 
        355                 360                 365             


Ser Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser 
    370                 375                 380                 


Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu 
385                 390                 395                 400 


Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu 
                405                 410                 415     


Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu 
            420                 425                 430         


Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln 
        435                 440                 445             


Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Gly Ser 
    450                 455                 460                 


Ala Ser Gly Ser Ala Ser Ala Gly Val Ser Lys Gly Glu Glu Leu Ile 
465                 470                 475                 480 


Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn 
                485                 490                 495     


His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly 
            500                 505                 510         


Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe 
        515                 520                 525             


Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe 
    530                 535                 540                 


Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro 
545                 550                 555                 560 


Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val 
                565                 570                 575     


Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr 
            580                 585                 590         


Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met 
        595                 600                 605             


Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro 
    610                 615                 620                 


Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val 
625                 630                 635                 640 


Gly Gly Ser His Leu Ile Ala Asn Ala Lys Thr Thr Tyr Arg Ser Lys 
                645                 650                 655     


Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr 
            660                 665                 670         


Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln 
        675                 680                 685             


His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly 
    690                 695                 700                 


His Lys Leu Asn 
705             


<210>  2
<211>  820
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  NON_CONS
<222>  (20)..(21)
<223>  Residues at these positions can be separated by a scFV_hinge 
       region of unknown length

<400>  2

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val 
            20                  25                  30          


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        35                  40                  45              


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    50                  55                  60                  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
65                  70                  75                  80  


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ala 
                85                  90                  95      


Ser Gly Ser Ala Ser Gly Ser Ala Ser Met Gly Val Gln Val Glu Thr 
            100                 105                 110         


Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys 
        115                 120                 125             


Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser 
    130                 135                 140                 


Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu 
145                 150                 155                 160 


Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln 
                165                 170                 175     


Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly 
            180                 185                 190         


His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu 
        195                 200                 205             


Leu Leu Lys Leu Glu Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
    210                 215                 220                 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ile His Leu Gly 
225                 230                 235                 240 


His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala Ala Ala Gln Thr Thr 
                245                 250                 255     


Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly 
            260                 265                 270         


Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Met Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         


Leu Gly Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Gly Ser Gly 
        355                 360                 365             


Ser Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser 
    370                 375                 380                 


Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu 
385                 390                 395                 400 


Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu 
                405                 410                 415     


Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu 
            420                 425                 430         


Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln 
        435                 440                 445             


Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Gly Ser 
    450                 455                 460                 


Ala Ser Gly Ser Ala Ser Ala Gly Arg Val Lys Phe Ser Arg Ser Ala 
465                 470                 475                 480 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                485                 490                 495     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            500                 505                 510         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        515                 520                 525             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    530                 535                 540                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
545                 550                 555                 560 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                565                 570                 575     


His Met Gln Ala Leu Pro Pro Arg Val Ser Lys Gly Glu Glu Leu Ile 
            580                 585                 590         


Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn 
        595                 600                 605             


His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly 
    610                 615                 620                 


Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe 
625                 630                 635                 640 


Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe 
                645                 650                 655     


Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro 
            660                 665                 670         


Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val 
        675                 680                 685             


Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr 
    690                 695                 700                 


Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met 
705                 710                 715                 720 


Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro 
                725                 730                 735     


Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val 
            740                 745                 750         


Gly Gly Ser His Leu Ile Ala Asn Ala Lys Thr Thr Tyr Arg Ser Lys 
        755                 760                 765             


Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr 
    770                 775                 780                 


Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln 
785                 790                 795                 800 


His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly 
                805                 810                 815     


His Lys Leu Asn 
            820 


<210>  3
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  NON_CONS
<222>  (20)..(21)
<223>  Residues at these positions can be separated by a scFV_hinge 
       region of unknown length

<400>  3

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val 
            20                  25                  30          


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        35                  40                  45              


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    50                  55                  60                  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
65                  70                  75                  80  


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ala 
                85                  90                  95      


Ser Gly Ser Ala Ser Gly Ser Ala Ser Met Lys Lys Lys Gly Ser Val 
            100                 105                 110         


Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ser Gln 
        115                 120                 125             


Gln Thr Arg Gly Leu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg 
    130                 135                 140                 


Asp Lys Asn Gln Val Glu Gly Glu Val Gln Val Val Ser Thr Ala Thr 
145                 150                 155                 160 


Gln Ser Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr 
                165                 170                 175     


His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr 
            180                 185                 190         


Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro 
        195                 200                 205             


Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu 
    210                 215                 220                 


Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly 
225                 230                 235                 240 


Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys 
                245                 250                 255     


Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly 
            260                 265                 270         


Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp 
        275                 280                 285             


Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu 
                325                 330                 335     


Leu Pro Val Ala Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu 
            340                 345                 350         


Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser 
        355                 360                 365             


Leu Ser Leu Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    370                 375                 380                 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
385                 390                 395                 400 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                405                 410                 415     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            420                 425                 430         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Gly Ser Ala Ser Gly Ser 
        435                 440                 445             


Ala Ser Gly Ser Ala Ser Gly Ser Gly Ser Asp Ile Glu Lys Leu Cys 
    450                 455                 460                 


Lys Lys Ala Glu Glu Glu Ala Lys Glu Ala Gln Glu Lys Ala Asp Glu 
465                 470                 475                 480 


Leu Arg Gln Arg His Pro Asp Ser Gln Ala Ala Glu Asp Ala Glu Asp 
                485                 490                 495     


Leu Ala Asn Leu Ala Val Ala Ala Val Leu Thr Ala Cys Leu Leu Ala 
            500                 505                 510         


Gln Glu His Pro Asn Ala Asp Ile Ala Lys Leu Cys Ile Lys Ala Ala 
        515                 520                 525             


Ser Glu Ala Ala Glu Ala Ala Ser Lys Ala Ala Glu Leu Ala Gln Arg 
    530                 535                 540                 


His Pro Asp Ser Gln Ala Ala Arg Asp Ala Ile Lys Leu Ala Ser Gln 
545                 550                 555                 560 


Ala Ala Arg Ala Val Ile Leu Ala Ile Met Leu Ala Ala Glu Asn Pro 
                565                 570                 575     


Asn Ala Asp Ile Ala Lys Leu Cys Ile Lys Ala Ala Ser Glu Ala Ala 
            580                 585                 590         


Glu Ala Ala Ser Lys Ala Ala Glu Leu Ala Gln Arg His Pro Asp Ser 
        595                 600                 605             


Gln Ala Ala Arg Asp Ala Ile Lys Leu Ala Ser Gln Ala Ala Glu Ala 
    610                 615                 620                 


Val Glu Arg Ala Ile Trp Leu Ala Ala Glu Asn Pro Asn Ala Asp Ile 
625                 630                 635                 640 


Ala Lys Lys Cys Ile Lys Ala Ala Ser Glu Ala Ala Glu Glu Ala Ser 
                645                 650                 655     


Lys Ala Ala Glu Glu Ala Gln Arg His Pro Asp Ser Gln Lys Ala Arg 
            660                 665                 670         


Asp Glu Ile Lys Glu Ala Ser Gln Lys Ala Glu Glu Val Lys Glu Arg 
        675                 680                 685             


Cys Lys Ser Gly Ser Ala Ser Gly Ser Ala Ser Ala Gly Arg Val Lys 
    690                 695                 700                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
705                 710                 715                 720 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                725                 730                 735     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            740                 745                 750         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        755                 760                 765             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    770                 775                 780                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
785                 790                 795                 800 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Val Ser Lys 
                805                 810                 815     


Gly Glu Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu 
            820                 825                 830         


Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly 
        835                 840                 845             


Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly 
    850                 855                 860                 


Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr 
865                 870                 875                 880 


Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 
                885                 890                 895     


Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 
            900                 905                 910         


Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp 
        915                 920                 925             


Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser 
    930                 935                 940                 


Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr 
945                 950                 955                 960 


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met 
                965                 970                 975     


Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ala Lys Thr 
            980                 985                 990         


Thr Tyr Arg Ser Lys Lys Pro Ala  Lys Asn Leu Lys Met  Pro Gly Val 
        995                 1000                 1005             


Tyr Tyr  Val Asp Tyr Arg Leu  Glu Arg Ile Lys Glu  Ala Asn Asn 
    1010                 1015                 1020             


Glu Thr  Tyr Val Glu Gln His  Glu Val Ala Val Ala  Arg Tyr Cys 
    1025                 1030                 1035             


Asp Leu  Pro Ser Lys Leu Gly  His Lys Leu Asn 
    1040                 1045                 


<210>  4
<211>  1045
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  NON_CONS
<222>  (20)..(21)
<223>  Residues at these positions can be separated by a scFV_hinge 
       region of unknown length

<400>  4

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val 
            20                  25                  30          


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        35                  40                  45              


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    50                  55                  60                  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
65                  70                  75                  80  


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ala 
                85                  90                  95      


Ser Gly Ser Ala Ser Gly Ser Ala Ser Met Lys Lys Lys Gly Ser Val 
            100                 105                 110         


Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ser Gln 
        115                 120                 125             


Gln Thr Arg Gly Leu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg 
    130                 135                 140                 


Asp Lys Asn Gln Val Glu Gly Glu Val Gln Val Val Ser Thr Ala Thr 
145                 150                 155                 160 


Gln Ser Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr 
                165                 170                 175     


His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr 
            180                 185                 190         


Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro 
        195                 200                 205             


Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu 
    210                 215                 220                 


Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly 
225                 230                 235                 240 


Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys 
                245                 250                 255     


Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly 
            260                 265                 270         


Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp 
        275                 280                 285             


Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu 
                325                 330                 335     


Leu Pro Val Ala Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu 
            340                 345                 350         


Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser 
        355                 360                 365             


Leu Ser Leu Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    370                 375                 380                 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
385                 390                 395                 400 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                405                 410                 415     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            420                 425                 430         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Gly Ser Ala Ser Gly Ser 
        435                 440                 445             


Ala Ser Gly Ser Ala Ser Gly Ser Gly Ser Ser Ser Asp Glu Glu Glu 
    450                 455                 460                 


Ala Arg Glu Leu Ile Glu Arg Ala Lys Glu Ala Ala Glu Arg Ala Gln 
465                 470                 475                 480 


Glu Ala Ala Glu Arg Thr Gly Asp Pro Arg Val Arg Glu Leu Ala Arg 
                485                 490                 495     


Glu Leu Lys Arg Leu Ala Gln Glu Ala Ala Glu Glu Val Lys Arg Asp 
            500                 505                 510         


Pro Ser Ser Ser Asp Val Asn Glu Ala Leu Lys Leu Ile Val Glu Ala 
        515                 520                 525             


Ile Glu Ala Ala Val Asp Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp 
    530                 535                 540                 


Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu 
545                 550                 555                 560 


Ala Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Ser Asp Val Asn Glu 
                565                 570                 575     


Ala Leu His Ser Ile Val Tyr Ala Ile Glu Ala Ala Ile Phe Ala Leu 
            580                 585                 590         


Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg 
        595                 600                 605             


Glu Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn 
    610                 615                 620                 


Pro Ser Ser Arg Asn Val Glu His Ala Leu Met Arg Ile Val Leu Ala 
625                 630                 635                 640 


Ile Tyr Leu Ala Glu Glu Asn Leu Arg Glu Ala Glu Glu Ser Gly Asp 
                645                 650                 655     


Pro Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg Glu Ala Val Glu 
            660                 665                 670         


Arg Ala Glu Glu Val Gln Arg Asp Pro Ser Gly Trp Leu Asn His Gly 
        675                 680                 685             


Ser Ala Ser Gly Ser Ala Ser Ala Gly Arg Val Lys Phe Ser Arg Ser 
    690                 695                 700                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
705                 710                 715                 720 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                725                 730                 735     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            740                 745                 750         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        755                 760                 765             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    770                 775                 780                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
785                 790                 795                 800 


Leu His Met Gln Ala Leu Pro Pro Arg Val Ser Lys Gly Glu Glu Leu 
                805                 810                 815     


Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp 
            820                 825                 830         


Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu 
        835                 840                 845             


Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro 
    850                 855                 860                 


Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr 
865                 870                 875                 880 


Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe 
                885                 890                 895     


Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly 
            900                 905                 910         


Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile 
        915                 920                 925             


Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val 
    930                 935                 940                 


Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr 
945                 950                 955                 960 


Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu 
                965                 970                 975     


Val Gly Gly Ser His Leu Ile Ala Asn Ala Lys Thr Thr Tyr Arg Ser 
            980                 985                 990         


Lys Lys Pro Ala Lys Asn Leu Lys  Met Pro Gly Val Tyr  Tyr Val Asp 
        995                 1000                 1005             


Tyr Arg  Leu Glu Arg Ile Lys  Glu Ala Asn Asn Glu  Thr Tyr Val 
    1010                 1015                 1020             


Glu Gln  His Glu Val Ala Val  Ala Arg Tyr Cys Asp  Leu Pro Ser 
    1025                 1030                 1035             


Lys Leu  Gly His Lys Leu Asn  
    1040                 1045 


<210>  5
<211>  849
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  NON_CONS
<222>  (20)..(21)
<223>  Residues at these positions can be separated by a scFV_hinge 
       region of unknown length

<400>  5

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val 
            20                  25                  30          


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        35                  40                  45              


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    50                  55                  60                  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
65                  70                  75                  80  


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ala 
                85                  90                  95      


Ser Gly Ser Ala Ser Gly Ser Ala Ser Met Lys Lys Lys Gly Ser Val 
            100                 105                 110         


Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ser Gln 
        115                 120                 125             


Gln Thr Arg Gly Leu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg 
    130                 135                 140                 


Asp Lys Asn Gln Val Glu Gly Glu Val Gln Val Val Ser Thr Ala Thr 
145                 150                 155                 160 


Gln Ser Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr 
                165                 170                 175     


His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr 
            180                 185                 190         


Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro 
        195                 200                 205             


Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu 
    210                 215                 220                 


Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly 
225                 230                 235                 240 


Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys 
                245                 250                 255     


Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly 
            260                 265                 270         


Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp 
        275                 280                 285             


Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu 
                325                 330                 335     


Leu Pro Val Ala Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu 
            340                 345                 350         


Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser 
        355                 360                 365             


Leu Ser Leu Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    370                 375                 380                 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
385                 390                 395                 400 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                405                 410                 415     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            420                 425                 430         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Gly Ser Ala Ser Gly Ser 
        435                 440                 445             


Ala Ser Gly Ser Ala Ser Gly Ser Gly Ser Gly Glu Leu Asp Glu Leu 
    450                 455                 460                 


Val Tyr Leu Leu Asp Gly Pro Gly Tyr Asp Pro Ile His Ser Asp Val 
465                 470                 475                 480 


Val Thr Arg Gly Gly Ser His Leu Phe Asn Phe Gly Ser Ala Ser Gly 
                485                 490                 495     


Ser Ala Ser Ala Gly Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            500                 505                 510         


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        515                 520                 525             


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    530                 535                 540                 


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
545                 550                 555                 560 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
                565                 570                 575     


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
            580                 585                 590         


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
        595                 600                 605             


Ala Leu Pro Pro Arg Val Ser Lys Gly Glu Glu Leu Ile Lys Glu Asn 
    610                 615                 620                 


Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn His His Phe 
625                 630                 635                 640 


Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr 
                645                 650                 655     


Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp 
            660                 665                 670         


Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe Ile Asn His 
        675                 680                 685             


Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe 
    690                 695                 700                 


Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr Ala 
705                 710                 715                 720 


Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val Lys 
                725                 730                 735     


Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met Gln Lys Lys 
            740                 745                 750         


Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala Asp Gly 
        755                 760                 765             


Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly Gly Ser 
    770                 775                 780                 


His Leu Ile Ala Asn Ala Lys Thr Thr Tyr Arg Ser Lys Lys Pro Ala 
785                 790                 795                 800 


Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg Leu Glu 
                805                 810                 815     


Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His Glu Val 
            820                 825                 830         


Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Lys Leu 
        835                 840                 845             


Asn 
    


<210>  6
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  NON_CONS
<222>  (20)..(21)
<223>  Residues at these positions can be separated by a scFV_hinge 
       region of unknown length

<400>  6

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val 
            20                  25                  30          


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        35                  40                  45              


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    50                  55                  60                  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
65                  70                  75                  80  


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ala 
                85                  90                  95      


Ser Gly Ser Ala Ser Gly Ser Ala Ser Met Ser Gln Ser Asn Arg Glu 
            100                 105                 110         


Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser 
        115                 120                 125             


Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro Glu 
    130                 135                 140                 


Gly Thr Glu Ser Glu Met Glu Thr Pro Ser Ala Ile Asn Gly Asn Pro 
145                 150                 155                 160 


Ser Trp His Leu Ala Asp Ser Pro Ala Val Asn Gly Ala Thr Gly His 
                165                 170                 175     


Ser Ser Ser Leu Asp Ala Arg Glu Val Ile Pro Met Ala Ala Val Lys 
            180                 185                 190         


Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg 
        195                 200                 205             


Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala 
    210                 215                 220                 


Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val 
225                 230                 235                 240 


Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys 
                245                 250                 255     


Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala 
            260                 265                 270         


Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln 
        275                 280                 285             


Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Met Ile His Leu Gly His Ile Leu Phe Leu Leu 
                325                 330                 335     


Leu Leu Pro Val Ala Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser 
            340                 345                 350         


Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly 
        355                 360                 365             


Ser Leu Ser Leu Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val 
    370                 375                 380                 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
385                 390                 395                 400 


Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
                405                 410                 415     


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            420                 425                 430         


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Gly Ser Ala Ser Gly 
        435                 440                 445             


Ser Ala Ser Gly Ser Ala Ser Gly Ser Gly Ser Ala Pro Pro Asn Leu 
    450                 455                 460                 


Trp Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu 
465                 470                 475                 480 


Phe Glu Gly Ser Phe Lys Gly Ser Ala Ser Gly Ser Ala Ser Ala Gly 
                485                 490                 495     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            500                 505                 510         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        515                 520                 525             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    530                 535                 540                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
545                 550                 555                 560 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                565                 570                 575     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            580                 585                 590         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        595                 600                 605             


Val Ser Lys Gly Glu Glu Leu Ile Lys Glu Asn Met His Met Lys Leu 
    610                 615                 620                 


Tyr Met Glu Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu 
625                 630                 635                 640 


Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val 
                645                 650                 655     


Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser 
            660                 665                 670         


Phe Leu Tyr Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro 
        675                 680                 685             


Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val 
    690                 695                 700                 


Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser 
705                 710                 715                 720 


Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn 
                725                 730                 735     


Phe Thr Ser Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu 
            740                 745                 750         


Ala Phe Thr Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg 
        755                 760                 765             


Asn Asp Met Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn 
    770                 775                 780                 


Ala Lys Thr Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met 
785                 790                 795                 800 


Pro Gly Val Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala 
                805                 810                 815     


Asn Asn Glu Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr 
            820                 825                 830         


Cys Asp Leu Pro Ser Lys Leu Gly His Lys Leu Asn 
        835                 840                 


<210>  7
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  NON_CONS
<222>  (20)..(21)
<223>  Residues at these positions can be separated by a scFV_hinge 
       region of unknown length

<400>  7

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val 
            20                  25                  30          


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        35                  40                  45              


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    50                  55                  60                  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
65                  70                  75                  80  


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                85                  90                  95      


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            100                 105                 110         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        115                 120                 125             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    130                 135                 140                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
145                 150                 155                 160 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                165                 170                 175     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            180                 185                 190         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        195                 200                 205         


<210>  8
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    50                  55                  60                  


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
65                  70                  75                  80  


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                85                  90                  95      


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            100                 105                 110         


Glu Gly Gly Cys Glu Leu Gly Ser Ala Ser Gly Ser Ala Ser Gly Ser 
        115                 120                 125             


Ala Ser Gly Ser Gly Ser Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg 
    130                 135                 140                 


Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe Glu Gly Ser Phe 
145                 150                 155                 160 


Lys Gly Ser Ala Ser Gly Ser Ala Ser Ala Gly Arg Val Lys Phe Ser 
                165                 170                 175     


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
            180                 185                 190         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        195                 200                 205             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    210                 215                 220                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
225                 230                 235                 240 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                245                 250                 255     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            260                 265                 270         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr 
        275                 280                 285             


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
    290                 295                 300                 


Pro Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His 
305                 310                 315                 320 


Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile 
                325                 330                 335     


Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His 
            340                 345                 350         


Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val 
        355                 360                 365             


Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln 
    370                 375                 380                 


Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu 
385                 390                 395                 400 


Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn 
                405                 410                 415     


Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu 
            420                 425                 430         


Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys 
        435                 440                 445             


Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys 
    450                 455                 460                 


Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln 
465                 470                 475                 480 


Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr 
                485                 490                 495     


Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro 
            500                 505                 510         


Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu 
        515                 520                 525             


Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val 
    530                 535                 540                 


Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala 
545                 550                 555                 560 


Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys 
                565                 570                 575     


Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly 
            580                 585                 590         


Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly 
        595                 600                 605             


His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly 
    610                 615                 620                 


Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile 
625                 630                 635                 640 


Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu 
                645                 650                 655     


Gly Ile Gly Leu Phe Met 
            660         


<210>  9
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    50                  55                  60                  


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
65                  70                  75                  80  


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                85                  90                  95      


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            100                 105                 110         


Glu Gly Gly Cys Glu Leu Gly Ser Ala Ser Gly Ser Ala Ser Gly Ser 
        115                 120                 125             


Ala Ser Gly Ser Gly Ser Gly Glu Leu Asp Glu Leu Val Tyr Leu Leu 
    130                 135                 140                 


Asp Gly Pro Gly Tyr Asp Pro Ile His Ser Asp Val Val Thr Arg Gly 
145                 150                 155                 160 


Gly Ser His Leu Phe Asn Phe Gly Ser Ala Ser Gly Ser Ala Ser Ala 
                165                 170                 175     


Gly Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            180                 185                 190         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        195                 200                 205             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    210                 215                 220                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
225                 230                 235                 240 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                245                 250                 255     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            260                 265                 270         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        275                 280                 285             


Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
    290                 295                 300                 


Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Val Thr Ser Leu Leu 
305                 310                 315                 320 


Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
            660                 665             


<210>  10
<211>  864
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    50                  55                  60                  


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
65                  70                  75                  80  


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                85                  90                  95      


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            100                 105                 110         


Glu Gly Gly Cys Glu Leu Gly Ser Ala Ser Gly Ser Ala Ser Gly Ser 
        115                 120                 125             


Ala Ser Gly Ser Gly Ser Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu 
    130                 135                 140                 


Ile Glu Arg Ala Lys Glu Ala Ala Glu Arg Ala Gln Glu Ala Ala Glu 
145                 150                 155                 160 


Arg Thr Gly Asp Pro Arg Val Arg Glu Leu Ala Arg Glu Leu Lys Arg 
                165                 170                 175     


Leu Ala Gln Glu Ala Ala Glu Glu Val Lys Arg Asp Pro Ser Ser Ser 
            180                 185                 190         


Asp Val Asn Glu Ala Leu Lys Leu Ile Val Glu Ala Ile Glu Ala Ala 
        195                 200                 205             


Val Asp Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg 
    210                 215                 220                 


Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu 
225                 230                 235                 240 


Val Gln Arg Asn Pro Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser 
                245                 250                 255     


Ile Val Tyr Ala Ile Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu 
            260                 265                 270         


Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg 
        275                 280                 285             


Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg 
    290                 295                 300                 


Asn Val Glu His Ala Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala 
305                 310                 315                 320 


Glu Glu Asn Leu Arg Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg 
                325                 330                 335     


Glu Lys Ala Arg Glu Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu 
            340                 345                 350         


Val Gln Arg Asp Pro Ser Gly Trp Leu Asn His Gly Ser Ala Ser Gly 
        355                 360                 365             


Ser Ala Ser Ala Gly Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Val 
            500                 505                 510         


Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile 
        515                 520                 525             


Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser 
    530                 535                 540                 


Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser 
545                 550                 555                 560 


Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser 
                565                 570                 575     


Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys 
            580                 585                 590         


Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu 
        595                 600                 605             


Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly 
    610                 615                 620                 


Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn 
625                 630                 635                 640 


Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp 
                645                 650                 655     


Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn 
            660                 665                 670         


Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser 
        675                 680                 685             


Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala 
    690                 695                 700                 


Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val 
705                 710                 715                 720 


Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn 
                725                 730                 735     


Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile 
            740                 745                 750         


Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr 
        755                 760                 765             


Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly 
    770                 775                 780                 


Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn 
785                 790                 795                 800 


Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys 
                805                 810                 815     


His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys 
            820                 825                 830         


Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly 
        835                 840                 845             


Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
    850                 855                 860                 


<210>  11
<211>  868
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    50                  55                  60                  


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
65                  70                  75                  80  


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                85                  90                  95      


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            100                 105                 110         


Glu Gly Gly Cys Glu Leu Gly Ser Ala Ser Gly Ser Ala Ser Gly Ser 
        115                 120                 125             


Ala Ser Gly Ser Gly Ser Asp Ile Glu Lys Leu Cys Lys Lys Ala Glu 
    130                 135                 140                 


Glu Glu Ala Lys Glu Ala Gln Glu Lys Ala Asp Glu Leu Arg Gln Arg 
145                 150                 155                 160 


His Pro Asp Ser Gln Ala Ala Glu Asp Ala Glu Asp Leu Ala Asn Leu 
                165                 170                 175     


Ala Val Ala Ala Val Leu Thr Ala Cys Leu Leu Ala Gln Glu His Pro 
            180                 185                 190         


Asn Ala Asp Ile Ala Lys Leu Cys Ile Lys Ala Ala Ser Glu Ala Ala 
        195                 200                 205             


Glu Ala Ala Ser Lys Ala Ala Glu Leu Ala Gln Arg His Pro Asp Ser 
    210                 215                 220                 


Gln Ala Ala Arg Asp Ala Ile Lys Leu Ala Ser Gln Ala Ala Arg Ala 
225                 230                 235                 240 


Val Ile Leu Ala Ile Met Leu Ala Ala Glu Asn Pro Asn Ala Asp Ile 
                245                 250                 255     


Ala Lys Leu Cys Ile Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser 
            260                 265                 270         


Lys Ala Ala Glu Leu Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg 
        275                 280                 285             


Asp Ala Ile Lys Leu Ala Ser Gln Ala Ala Glu Ala Val Glu Arg Ala 
    290                 295                 300                 


Ile Trp Leu Ala Ala Glu Asn Pro Asn Ala Asp Ile Ala Lys Lys Cys 
305                 310                 315                 320 


Ile Lys Ala Ala Ser Glu Ala Ala Glu Glu Ala Ser Lys Ala Ala Glu 
                325                 330                 335     


Glu Ala Gln Arg His Pro Asp Ser Gln Lys Ala Arg Asp Glu Ile Lys 
            340                 345                 350         


Glu Ala Ser Gln Lys Ala Glu Glu Val Lys Glu Arg Cys Lys Ser Gly 
        355                 360                 365             


Ser Ala Ser Gly Ser Ala Ser Ala Gly Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe 
                485                 490                 495     


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            500                 505                 510         


Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
        515                 520                 525             


Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu 
    530                 535                 540                 


Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys 
545                 550                 555                 560 


Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe 
                565                 570                 575     


Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu 
            580                 585                 590         


Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln 
        595                 600                 605             


Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu 
    610                 615                 620                 


Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val 
625                 630                 635                 640 


Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile 
                645                 650                 655     


Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala 
            660                 665                 670         


Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr 
        675                 680                 685             


Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln 
    690                 695                 700                 


Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro 
705                 710                 715                 720 


Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val 
                725                 730                 735     


Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn 
            740                 745                 750         


Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn 
        755                 760                 765             


Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His 
    770                 775                 780                 


Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met 
785                 790                 795                 800 


Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val 
                805                 810                 815     


Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly 
            820                 825                 830         


Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr 
        835                 840                 845             


Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile 
    850                 855                 860                 


Gly Leu Phe Met 
865             


<210>  12
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  NON_CONS
<222>  (20)..(21)
<223>  Residues at these positions can be separated by a scFV_hinge 
       region of unknown length

<400>  12

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val 
            20                  25                  30          


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        35                  40                  45              


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    50                  55                  60                  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
65                  70                  75                  80  


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                85                  90                  95      


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            100                 105                 110         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        115                 120                 125             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    130                 135                 140                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
145                 150                 155                 160 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                165                 170                 175     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            180                 185                 190         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser 
        195                 200                 205             


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
    210                 215                 220                 


Asn Pro Gly Pro Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu 
225                 230                 235                 240 


Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly 
                245                 250                 255     


Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn 
            260                 265                 270         


Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile 
        275                 280                 285             


Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu 
    290                 295                 300                 


Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly 
305                 310                 315                 320 


Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala 
                325                 330                 335     


Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln 
            340                 345                 350         


Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg 
        355                 360                 365             


Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys 
    370                 375                 380                 


Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr 
385                 390                 395                 400 


Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys 
                405                 410                 415     


Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys 
            420                 425                 430         


Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg 
        435                 440                 445             


Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg 
    450                 455                 460                 


Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu 
465                 470                 475                 480 


Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys 
                485                 490                 495     


Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys 
            500                 505                 510         


Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala 
        515                 520                 525             


Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly 
    530                 535                 540                 


Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile 
545                 550                 555                 560 


Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val 
                565                 570                 575     


Val Ala Leu Gly Ile Gly Leu Phe Met 
            580                 585 


<210>  13
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  NON_CONS
<222>  (20)..(21)
<223>  Residues at these positions can be separated by a scFV_hinge 
       region of unknown length

<400>  13

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val 
            20                  25                  30          


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        35                  40                  45              


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    50                  55                  60                  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
65                  70                  75                  80  


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ala 
                85                  90                  95      


Ser Gly Ser Ala Ser Gly Ser Ala Ser Met Ser Gln Ser Asn Arg Glu 
            100                 105                 110         


Leu Val Val Asp Phe Leu Ser Tyr Lys Leu Ser Gln Lys Gly Tyr Ser 
        115                 120                 125             


Trp Ser Gln Phe Ser Asp Val Glu Glu Asn Arg Thr Glu Ala Pro Glu 
    130                 135                 140                 


Gly Thr Glu Ser Glu Met Glu Thr Pro Ser Ala Ile Asn Gly Asn Pro 
145                 150                 155                 160 


Ser Trp His Leu Ala Asp Ser Pro Ala Val Asn Gly Ala Thr Gly His 
                165                 170                 175     


Ser Ser Ser Leu Asp Ala Arg Glu Val Ile Pro Met Ala Ala Val Lys 
            180                 185                 190         


Gln Ala Leu Arg Glu Ala Gly Asp Glu Phe Glu Leu Arg Tyr Arg Arg 
        195                 200                 205             


Ala Phe Ser Asp Leu Thr Ser Gln Leu His Ile Thr Pro Gly Thr Ala 
    210                 215                 220                 


Tyr Gln Ser Phe Glu Gln Val Val Asn Glu Leu Phe Arg Asp Gly Val 
225                 230                 235                 240 


Asn Trp Gly Arg Ile Val Ala Phe Phe Ser Phe Gly Gly Ala Leu Cys 
                245                 250                 255     


Val Glu Ser Val Asp Lys Glu Met Gln Val Leu Val Ser Arg Ile Ala 
            260                 265                 270         


Ala Trp Met Ala Thr Tyr Leu Asn Asp His Leu Glu Pro Trp Ile Gln 
        275                 280                 285             


Glu Asn Gly Gly Trp Asp Thr Phe Val Glu Leu Tyr Gly Asn Asn 
    290                 295                 300             


<210>  14
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  NON_CONS
<222>  (20)..(21)
<223>  Residues at these positions can be separated by a scFV_hinge 
       region of unknown length

<400>  14

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val 
            20                  25                  30          


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        35                  40                  45              


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    50                  55                  60                  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
65                  70                  75                  80  


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ala 
                85                  90                  95      


Ser Gly Ser Ala Ser Gly Ser Ala Ser Met Lys Lys Lys Gly Ser Val 
            100                 105                 110         


Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ser Gln 
        115                 120                 125             


Gln Thr Arg Gly Leu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg 
    130                 135                 140                 


Asp Lys Asn Gln Val Glu Gly Glu Val Gln Val Val Ser Thr Ala Thr 
145                 150                 155                 160 


Gln Ser Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr 
                165                 170                 175     


His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr 
            180                 185                 190         


Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro 
        195                 200                 205             


Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu 
    210                 215                 220                 


Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly 
225                 230                 235                 240 


Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys 
                245                 250                 255     


Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly 
            260                 265                 270         


Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp 
        275                 280                 285             


Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro 
    290                 295                 300         


<210>  15
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Met Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu Ile Glu Arg Ala Lys 
1               5                   10                  15      


Glu Ala Ala Glu Arg Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro 
            20                  25                  30          


Arg Val Arg Glu Leu Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala 
        35                  40                  45              


Ala Glu Glu Val Lys Arg Asp Pro Ser Ser Ser Asp Val Asn Glu Ala 
    50                  55                  60                  


Leu Lys Leu Ile Val Glu Ala Ile Glu Ala Ala Val Asp Ala Leu Glu 
65                  70                  75                  80  


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
                85                  90                  95      


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
            100                 105                 110         


Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser Ile Val Tyr Ala Ile 
        115                 120                 125             


Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro 
    130                 135                 140                 


Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala 
145                 150                 155                 160 


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala 
                165                 170                 175     


Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg 
            180                 185                 190         


Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu 
        195                 200                 205             


Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp Pro 
    210                 215                 220                 


Ser Gly Trp Leu Asn His Ser Gly Ser Ala Ser Gly Ser Gly Gly Phe 
225                 230                 235                 240 


Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala 
                245                 250                 255     


Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn 
            260                 265                 270         


Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn 
        275                 280                 285             


Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met 
    290                 295                 300                 


Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu 
305                 310                 315                 320 


Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys Val Val 
                325                 330                 335     


Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly 
            340                 345                 350         


Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val 
        355                 360                 365             


Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys 
    370                 375                 380                 


Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe 
385                 390                 395                 400 


Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro 
                405                 410                 415     


Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln 
            420                 425                 430         


Leu Ala Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser 
        435                 440                 445             


Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly 
    450                 455                 460                 


Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His 
465                 470                 475                 480 


Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser 
                485                 490                 495     


Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg 
            500                 505                 510         


Lys Lys Leu Phe Phe Lys Thr Ser Gly Ser Gly Ala Thr Asn Phe Ser 
        515                 520                 525             


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val 
    530                 535                 540                 


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
545                 550                 555                 560 


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
                565                 570                 575     


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
            580                 585                 590         


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
        595                 600                 605             


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
    610                 615                 620                 


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
625                 630                 635                 640 


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
                645                 650                 655     


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
            660                 665                 670         


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
        675                 680                 685             


Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile 
    690                 695                 700                 


Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
705                 710                 715                 720 


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
                725                 730                 735     


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
            740                 745                 750         


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
        755                 760                 765             


Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
    770                 775                 780     


<210>  16
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Met Leu Glu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
1               5                   10                  15      


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
            20                  25                  30          


Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro 
        35                  40                  45              


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
    50                  55                  60                  


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
                85                  90                  95      


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly 
            100                 105                 110         


Gly Gly Ser Gly Val Asp Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 
        115                 120                 125             


Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 
    130                 135                 140                 


Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 
145                 150                 155                 160 


Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 
                165                 170                 175     


Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr 
            180                 185                 190         


Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His 
        195                 200                 205             


Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln 
    210                 215                 220                 


Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys 
225                 230                 235                 240 


Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys 
                245                 250                 255     


Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly 
            260                 265                 270         


Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu 
        275                 280                 285             


Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln 
    290                 295                 300                 


Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro 
305                 310                 315                 320 


Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val 
                325                 330                 335     


Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp 
            340                 345                 350         


Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu 
        355                 360                 365             


Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met 
    370                 375                 380                 


Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
385                 390                 395                 400 


<210>  17
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Met Leu Glu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
1               5                   10                  15      


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
            20                  25                  30          


Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro 
        35                  40                  45              


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
    50                  55                  60                  


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
                85                  90                  95      


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly 
            100                 105                 110         


Gly Gly Ser Gly Val Asp Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 
        115                 120                 125             


Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 
    130                 135                 140                 


Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 
145                 150                 155                 160 


Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 
                165                 170                 175     


Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr 
            180                 185                 190         


Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His 
        195                 200                 205             


Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln 
    210                 215                 220                 


Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys 
225                 230                 235                 240 


Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys 
                245                 250                 255     


Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly 
            260                 265                 270         


Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu 
        275                 280                 285             


Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln 
    290                 295                 300                 


Glu Gly Leu Arg Thr Phe Asp Gln Leu Ala Ala Ile Ser Ser Leu Pro 
305                 310                 315                 320 


Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val 
                325                 330                 335     


Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp 
            340                 345                 350         


Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu 
        355                 360                 365             


Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met 
    370                 375                 380                 


Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr 
385                 390                 395                 


<210>  18
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Tyr Ser Gly Gly Gly Ser Leu Glu Gly Val Gln Val Glu 
            100                 105                 110         


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
        115                 120                 125             


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp 
    130                 135                 140                 


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
145                 150                 155                 160 


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
                165                 170                 175     


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
            180                 185                 190         


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
        195                 200                 205             


Glu Leu Leu Lys Leu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Val Asp Gly Phe Gly Asp Val Gly Ala 
225                 230                 235                 240 


Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met 
                245                 250                 255     


Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg 
            260                 265                 270         


Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys 
        275                 280                 285             


Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly 
    290                 295                 300                 


Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln 
305                 310                 315                 320 


Gln Asp His Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His 
                325                 330                 335     


Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr 
            340                 345                 350         


Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly 
        355                 360                 365             


Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln 
    370                 375                 380                 


Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr 
385                 390                 395                 400 


Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr 
                405                 410                 415     


Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser 
            420                 425                 430         


Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro 
        435                 440                 445             


Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu 
    450                 455                 460                 


Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln 
465                 470                 475                 480 


Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr 
                485                 490                 495     


Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe 
            500                 505                 510         


Lys Thr Ser 
        515 


<210>  19
<211>  1027
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
1               5                   10                  15      


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln 
            20                  25                  30          


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn 
    50                  55                  60                  


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
                85                  90                  95      


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro Ser Gly Gly Gly Ser Gly Val Asp Gly Phe Gly 
        195                 200                 205             


Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr 
    210                 215                 220                 


Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val 
225                 230                 235                 240 


Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile 
                245                 250                 255     


Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met Val 
            260                 265                 270         


Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu 
        275                 280                 285             


Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys Val Val Val 
    290                 295                 300                 


Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala 
305                 310                 315                 320 


Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn 
                325                 330                 335     


Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu 
            340                 345                 350         


Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu 
        355                 360                 365             


Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu 
    370                 375                 380                 


Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu 
385                 390                 395                 400 


Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr 
                405                 410                 415     


Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser 
            420                 425                 430         


Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser 
        435                 440                 445             


Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val 
    450                 455                 460                 


Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys 
465                 470                 475                 480 


Lys Leu Phe Phe Lys Thr Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu 
                485                 490                 495     


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Ser Asp Glu 
            500                 505                 510         


Glu Glu Ala Arg Glu Leu Ile Glu Arg Ala Lys Glu Ala Ala Glu Arg 
        515                 520                 525             


Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro Arg Val Arg Glu Leu 
    530                 535                 540                 


Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala Ala Glu Glu Val Lys 
545                 550                 555                 560 


Arg Asp Pro Ser Ser Ser Asp Val Asn Glu Ala Leu Lys Leu Ile Val 
                565                 570                 575     


Glu Ala Ile Glu Ala Ala Val Asp Ala Leu Glu Ala Ala Glu Arg Thr 
            580                 585                 590         


Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala 
        595                 600                 605             


Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Ser Asp Val 
    610                 615                 620                 


Asn Glu Ala Leu His Ser Ile Val Tyr Ala Ile Glu Ala Ala Ile Phe 
625                 630                 635                 640 


Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu 
                645                 650                 655     


Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln 
            660                 665                 670         


Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala Leu Met Arg Ile Val 
        675                 680                 685             


Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg Glu Ala Glu Glu Ser 
    690                 695                 700                 


Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg Glu Ala 
705                 710                 715                 720 


Val Glu Arg Ala Glu Glu Val Gln Arg Asp Pro Ser Gly Trp Leu Asn 
                725                 730                 735     


His Ser Gly Gly Gly Ser Gly Val Asp Gly Phe Gly Asp Val Gly Ala 
            740                 745                 750         


Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met 
        755                 760                 765             


Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg 
    770                 775                 780                 


Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys 
785                 790                 795                 800 


Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly 
                805                 810                 815     


Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln 
            820                 825                 830         


Gln Asp His Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His 
        835                 840                 845             


Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr 
    850                 855                 860                 


Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly 
865                 870                 875                 880 


Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln 
                885                 890                 895     


Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr 
            900                 905                 910         


Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr 
        915                 920                 925             


Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser 
    930                 935                 940                 


Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro 
945                 950                 955                 960 


Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu 
                965                 970                 975     


Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln 
            980                 985                 990         


Ser Leu Leu Leu Arg Val Ala Asn  Ala Val Ser Val Lys  Gly Ile Tyr 
        995                 1000                 1005             


Lys Gln  Met Pro Gly Cys Phe  Asn Phe Leu Arg Lys  Lys Leu Phe 
    1010                 1015                 1020             


Phe Lys  Thr Ser 
    1025         


<210>  20
<211>  1031
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
1               5                   10                  15      


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln 
            20                  25                  30          


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn 
    50                  55                  60                  


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
                85                  90                  95      


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro Ser Gly Gly Gly Ser Gly Val Asp Gly Phe Gly 
        195                 200                 205             


Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr 
    210                 215                 220                 


Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val 
225                 230                 235                 240 


Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile 
                245                 250                 255     


Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met Val 
            260                 265                 270         


Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu 
        275                 280                 285             


Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys Val Val Val 
    290                 295                 300                 


Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala 
305                 310                 315                 320 


Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn 
                325                 330                 335     


Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu 
            340                 345                 350         


Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu 
        355                 360                 365             


Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu 
    370                 375                 380                 


Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu 
385                 390                 395                 400 


Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr 
                405                 410                 415     


Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser 
            420                 425                 430         


Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser 
        435                 440                 445             


Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val 
    450                 455                 460                 


Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys 
465                 470                 475                 480 


Lys Leu Phe Phe Lys Thr Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu 
                485                 490                 495     


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Asp Ile Glu Lys 
            500                 505                 510         


Leu Cys Lys Lys Ala Glu Glu Glu Ala Lys Glu Ala Gln Glu Lys Ala 
        515                 520                 525             


Asp Glu Leu Arg Gln Arg His Pro Asp Ser Gln Ala Ala Glu Asp Ala 
    530                 535                 540                 


Glu Asp Leu Ala Asn Leu Ala Val Ala Ala Val Leu Thr Ala Cys Leu 
545                 550                 555                 560 


Leu Ala Gln Glu His Pro Asn Ala Asp Ile Ala Lys Leu Cys Ile Lys 
                565                 570                 575     


Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys Ala Ala Glu Leu Ala 
            580                 585                 590         


Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp Ala Ile Lys Leu Ala 
        595                 600                 605             


Ser Gln Ala Ala Arg Ala Val Ile Leu Ala Ile Met Leu Ala Ala Glu 
    610                 615                 620                 


Asn Pro Asn Ala Asp Ile Ala Lys Leu Cys Ile Lys Ala Ala Ser Glu 
625                 630                 635                 640 


Ala Ala Glu Ala Ala Ser Lys Ala Ala Glu Leu Ala Gln Arg His Pro 
                645                 650                 655     


Asp Ser Gln Ala Ala Arg Asp Ala Ile Lys Leu Ala Ser Gln Ala Ala 
            660                 665                 670         


Glu Ala Val Glu Arg Ala Ile Trp Leu Ala Ala Glu Asn Pro Asn Ala 
        675                 680                 685             


Asp Ile Ala Lys Lys Cys Ile Lys Ala Ala Ser Glu Ala Ala Glu Glu 
    690                 695                 700                 


Ala Ser Lys Ala Ala Glu Glu Ala Gln Arg His Pro Asp Ser Gln Lys 
705                 710                 715                 720 


Ala Arg Asp Glu Ile Lys Glu Ala Ser Gln Lys Ala Glu Glu Val Lys 
                725                 730                 735     


Glu Arg Cys Lys Ser Ser Gly Gly Gly Ser Gly Val Asp Gly Phe Gly 
            740                 745                 750         


Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr 
        755                 760                 765             


Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val 
    770                 775                 780                 


Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile 
785                 790                 795                 800 


Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met Val 
                805                 810                 815     


Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu 
            820                 825                 830         


Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys Val Val Val 
        835                 840                 845             


Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala 
    850                 855                 860                 


Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn 
865                 870                 875                 880 


Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu 
                885                 890                 895     


Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu 
            900                 905                 910         


Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu 
        915                 920                 925             


Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu 
    930                 935                 940                 


Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr 
945                 950                 955                 960 


Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser 
                965                 970                 975     


Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser 
            980                 985                 990         


Glu Asp Leu Gln Ser Leu Leu Leu  Arg Val Ala Asn Ala  Val Ser Val 
        995                 1000                 1005             


Lys Gly  Ile Tyr Lys Gln Met  Pro Gly Cys Phe Asn  Phe Leu Arg 
    1010                 1015                 1020             


Lys Lys  Leu Phe Phe Lys Thr  Ser 
    1025                 1030     


<210>  21
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
1               5                   10                  15      


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln 
            20                  25                  30          


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn 
    50                  55                  60                  


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
                85                  90                  95      


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro Ser Gly Gly Gly Ser Ser Ser Asp Glu Glu Glu 
        195                 200                 205             


Ala Arg Glu Leu Ile Glu Arg Ala Lys Glu Ala Ala Glu Arg Ala Gln 
    210                 215                 220                 


Glu Ala Ala Glu Arg Thr Gly Asp Pro Arg Val Arg Glu Leu Ala Arg 
225                 230                 235                 240 


Glu Leu Lys Arg Leu Ala Gln Glu Ala Ala Glu Glu Val Lys Arg Asp 
                245                 250                 255     


Pro Ser Ser Ser Asp Val Asn Glu Ala Leu Lys Leu Ile Val Glu Ala 
            260                 265                 270         


Ile Glu Ala Ala Val Asp Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp 
        275                 280                 285             


Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu 
    290                 295                 300                 


Ala Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Ser Asp Val Asn Glu 
305                 310                 315                 320 


Ala Leu His Ser Ile Val Tyr Ala Ile Glu Ala Ala Ile Phe Ala Leu 
                325                 330                 335     


Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg 
            340                 345                 350         


Glu Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn 
        355                 360                 365             


Pro Ser Ser Arg Asn Val Glu His Ala Leu Met Arg Ile Val Leu Ala 
    370                 375                 380                 


Ile Tyr Leu Ala Glu Glu Asn Leu Arg Glu Ala Glu Glu Ser Gly Asp 
385                 390                 395                 400 


Pro Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg Glu Ala Val Glu 
                405                 410                 415     


Arg Ala Glu Glu Val Gln Arg Asp Pro Ser Gly Trp Leu Asn His Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val Asp Gly Phe Gly 
        435                 440                 445             


Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr 
    450                 455                 460                 


Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val 
465                 470                 475                 480 


Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile 
                485                 490                 495     


Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met Val 
            500                 505                 510         


Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu 
        515                 520                 525             


Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys Val Val Val 
    530                 535                 540                 


Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala 
545                 550                 555                 560 


Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn 
                565                 570                 575     


Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu 
            580                 585                 590         


Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu 
        595                 600                 605             


Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu 
    610                 615                 620                 


Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu 
625                 630                 635                 640 


Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr 
                645                 650                 655     


Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser 
            660                 665                 670         


Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser 
        675                 680                 685             


Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val 
    690                 695                 700                 


Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys 
705                 710                 715                 720 


Lys Leu Phe Phe Lys Thr Ser 
                725         


<210>  22
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
1               5                   10                  15      


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln 
            20                  25                  30          


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn 
    50                  55                  60                  


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
                85                  90                  95      


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro Ser Gly Gly Gly Ser Asp Ile Glu Lys Leu Cys 
        195                 200                 205             


Lys Lys Ala Glu Glu Glu Ala Lys Glu Ala Gln Glu Lys Ala Asp Glu 
    210                 215                 220                 


Leu Arg Gln Arg His Pro Asp Ser Gln Ala Ala Glu Asp Ala Glu Asp 
225                 230                 235                 240 


Leu Ala Asn Leu Ala Val Ala Ala Val Leu Thr Ala Cys Leu Leu Ala 
                245                 250                 255     


Gln Glu His Pro Asn Ala Asp Ile Ala Lys Leu Cys Ile Lys Ala Ala 
            260                 265                 270         


Ser Glu Ala Ala Glu Ala Ala Ser Lys Ala Ala Glu Leu Ala Gln Arg 
        275                 280                 285             


His Pro Asp Ser Gln Ala Ala Arg Asp Ala Ile Lys Leu Ala Ser Gln 
    290                 295                 300                 


Ala Ala Arg Ala Val Ile Leu Ala Ile Met Leu Ala Ala Glu Asn Pro 
305                 310                 315                 320 


Asn Ala Asp Ile Ala Lys Leu Cys Ile Lys Ala Ala Ser Glu Ala Ala 
                325                 330                 335     


Glu Ala Ala Ser Lys Ala Ala Glu Leu Ala Gln Arg His Pro Asp Ser 
            340                 345                 350         


Gln Ala Ala Arg Asp Ala Ile Lys Leu Ala Ser Gln Ala Ala Glu Ala 
        355                 360                 365             


Val Glu Arg Ala Ile Trp Leu Ala Ala Glu Asn Pro Asn Ala Asp Ile 
    370                 375                 380                 


Ala Lys Lys Cys Ile Lys Ala Ala Ser Glu Ala Ala Glu Glu Ala Ser 
385                 390                 395                 400 


Lys Ala Ala Glu Glu Ala Gln Arg His Pro Asp Ser Gln Lys Ala Arg 
                405                 410                 415     


Asp Glu Ile Lys Glu Ala Ser Gln Lys Ala Glu Glu Val Lys Glu Arg 
            420                 425                 430         


Cys Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val 
        435                 440                 445             


Asp Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala 
    450                 455                 460                 


Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile 
465                 470                 475                 480 


Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr 
                485                 490                 495     


Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu 
            500                 505                 510         


His Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val 
        515                 520                 525             


Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys 
    530                 535                 540                 


Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln 
545                 550                 555                 560 


Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu 
                565                 570                 575     


Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly 
            580                 585                 590         


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp 
        595                 600                 605             


His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly 
    610                 615                 620                 


Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr 
625                 630                 635                 640 


Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile 
                645                 650                 655     


Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro 
            660                 665                 670         


Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln 
        675                 680                 685             


Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn 
    690                 695                 700                 


Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn 
705                 710                 715                 720 


Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
                725                 730     


<210>  23
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Met Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu Ile Glu Arg Ala Lys 
1               5                   10                  15      


Glu Ala Ala Glu Arg Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro 
            20                  25                  30          


Arg Val Arg Glu Leu Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala 
        35                  40                  45              


Ala Glu Glu Val Lys Arg Asp Pro Ser Ser Ser Asp Val Asn Glu Ala 
    50                  55                  60                  


Leu Lys Leu Ile Val Glu Ala Ile Glu Ala Ala Val Asp Ala Leu Glu 
65                  70                  75                  80  


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
                85                  90                  95      


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
            100                 105                 110         


Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser Ile Val Tyr Ala Ile 
        115                 120                 125             


Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro 
    130                 135                 140                 


Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala 
145                 150                 155                 160 


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala 
                165                 170                 175     


Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg 
            180                 185                 190         


Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu 
        195                 200                 205             


Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp Pro 
    210                 215                 220                 


Ser Gly Trp Leu Asn His Ser Gly Gly Ser Gly Ser Gly Ser Lys Lys 
225                 230                 235                 240 


Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr 
                245                 250                 255     


Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln Glu Thr Ser 
            260                 265                 270         


Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val 
        275                 280                 285             


Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn Gly Val Leu 
    290                 295                 300                 


Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys 
305                 310                 315                 320 


Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly 
                325                 330                 335     


Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly 
            340                 345                 350         


Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val 
        355                 360                 365             


Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile 
    370                 375                 380                 


Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly 
385                 390                 395                 400 


His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala 
                405                 410                 415     


Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg 
            420                 425                 430         


Ser Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val Asp 
        435                 440                 445             


Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp 
    450                 455                 460                 


Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile 
465                 470                 475                 480 


Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly 
                485                 490                 495     


Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His 
            500                 505                 510         


Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu 
        515                 520                 525             


Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys 
    530                 535                 540                 


Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe 
545                 550                 555                 560 


Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys 
                565                 570                 575     


Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys 
            580                 585                 590         


Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His 
        595                 600                 605             


Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser 
    610                 615                 620                 


Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe 
625                 630                 635                 640 


Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe 
                645                 650                 655     


Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys 
            660                 665                 670         


Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp 
        675                 680                 685             


Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala 
    690                 695                 700                 


Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe 
705                 710                 715                 720 


Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
                725                 730 


<210>  24
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Met Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu Ile Glu Arg Ala Lys 
1               5                   10                  15      


Glu Ala Ala Glu Arg Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro 
            20                  25                  30          


Arg Val Arg Glu Leu Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala 
        35                  40                  45              


Ala Glu Glu Val Lys Arg Asp Pro Ser Ser Ser Asp Val Asn Glu Ala 
    50                  55                  60                  


Leu Lys Leu Ile Val Glu Ala Ile Glu Ala Ala Val Asp Ala Leu Glu 
65                  70                  75                  80  


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
                85                  90                  95      


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
            100                 105                 110         


Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser Ile Val Tyr Ala Ile 
        115                 120                 125             


Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro 
    130                 135                 140                 


Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala 
145                 150                 155                 160 


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala 
                165                 170                 175     


Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg 
            180                 185                 190         


Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu 
        195                 200                 205             


Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp Pro 
    210                 215                 220                 


Ser Gly Trp Leu Asn His Ser Gly Gly Gly Ser Lys Lys Lys Gly Ser 
225                 230                 235                 240 


Val Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ala 
                245                 250                 255     


Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly 
            260                 265                 270         


Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala 
        275                 280                 285             


Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val 
    290                 295                 300                 


Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val 
305                 310                 315                 320 


Thr Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala 
                325                 330                 335     


Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp 
            340                 345                 350         


Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg 
        355                 360                 365             


Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu 
    370                 375                 380                 


Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val 
385                 390                 395                 400 


Gly Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val 
                405                 410                 415     


Asp Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val Asp Gly Phe Gly 
        435                 440                 445             


Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr 
    450                 455                 460                 


Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val 
465                 470                 475                 480 


Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile 
                485                 490                 495     


Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met Val 
            500                 505                 510         


Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu 
        515                 520                 525             


Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys Val Val Val 
    530                 535                 540                 


Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala 
545                 550                 555                 560 


Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn 
                565                 570                 575     


Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu 
            580                 585                 590         


Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu 
        595                 600                 605             


Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu 
    610                 615                 620                 


Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu 
625                 630                 635                 640 


Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr 
                645                 650                 655     


Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser 
            660                 665                 670         


Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser 
        675                 680                 685             


Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val 
    690                 695                 700                 


Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys 
705                 710                 715                 720 


Lys Leu Phe Phe Lys Thr Ser 
                725         


<210>  25
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Met Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu Ile Glu Arg Ala Lys 
1               5                   10                  15      


Glu Ala Ala Glu Arg Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro 
            20                  25                  30          


Arg Val Arg Glu Leu Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala 
        35                  40                  45              


Ala Glu Glu Val Lys Arg Asp Pro Ser Ser Ser Asp Val Asn Glu Ala 
    50                  55                  60                  


Leu Lys Leu Ile Val Glu Ala Ile Glu Ala Ala Val Asp Ala Leu Glu 
65                  70                  75                  80  


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
                85                  90                  95      


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
            100                 105                 110         


Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser Ile Val Tyr Ala Ile 
        115                 120                 125             


Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro 
    130                 135                 140                 


Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala 
145                 150                 155                 160 


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala 
                165                 170                 175     


Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg 
            180                 185                 190         


Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu 
        195                 200                 205             


Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp Pro 
    210                 215                 220                 


Ser Gly Trp Leu Asn His Ser Gly Ser Lys Lys Lys Gly Ser Val Val 
225                 230                 235                 240 


Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ala Gln Gln 
                245                 250                 255     


Thr Arg Gly Glu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg Asp 
            260                 265                 270         


Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr Gln 
        275                 280                 285             


Thr Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr His 
    290                 295                 300                 


Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr Gln 
305                 310                 315                 320 


Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro Gln 
                325                 330                 335     


Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr 
            340                 345                 350         


Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp 
        355                 360                 365             


Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly 
    370                 375                 380                 


Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Ile 
385                 390                 395                 400 


Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp Phe 
                405                 410                 415     


Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Val Asp Gly Phe Gly Asp Val 
        435                 440                 445             


Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu 
    450                 455                 460                 


Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe 
465                 470                 475                 480 


Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys 
                485                 490                 495     


Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met Val Glu Val 
            500                 505                 510         


Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu 
        515                 520                 525             


Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu 
    530                 535                 540                 


Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr 
545                 550                 555                 560 


Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe 
                565                 570                 575     


Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe 
            580                 585                 590         


Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala 
        595                 600                 605             


Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp 
    610                 615                 620                 


Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala 
625                 630                 635                 640 


Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr 
                645                 650                 655     


Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr 
            660                 665                 670         


Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp 
        675                 680                 685             


Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly 
    690                 695                 700                 


Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu 
705                 710                 715                 720 


Phe Phe Lys Thr Ser 
                725 


<210>  26
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Met Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu Ile Glu Arg Ala Lys 
1               5                   10                  15      


Glu Ala Ala Glu Arg Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro 
            20                  25                  30          


Arg Val Arg Glu Leu Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala 
        35                  40                  45              


Ala Glu Glu Val Lys Arg Asp Pro Ser Ser Ser Asp Val Asn Glu Ala 
    50                  55                  60                  


Leu Lys Leu Ile Val Glu Ala Ile Glu Ala Ala Val Asp Ala Leu Glu 
65                  70                  75                  80  


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
                85                  90                  95      


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
            100                 105                 110         


Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser Ile Val Tyr Ala Ile 
        115                 120                 125             


Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro 
    130                 135                 140                 


Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala 
145                 150                 155                 160 


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala 
                165                 170                 175     


Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg 
            180                 185                 190         


Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu 
        195                 200                 205             


Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp Pro 
    210                 215                 220                 


Ser Gly Trp Leu Asn His Lys Lys Lys Gly Ser Val Val Ile Val Gly 
225                 230                 235                 240 


Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly 
                245                 250                 255     


Glu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln 
            260                 265                 270         


Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu 
        275                 280                 285             


Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly 
    290                 295                 300                 


Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr 
305                 310                 315                 320 


Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg 
                325                 330                 335     


Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr 
            340                 345                 350         


Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly 
        355                 360                 365             


Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly 
    370                 375                 380                 


Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala 
385                 390                 395                 400 


Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val 
                405                 410                 415     


Glu Ser Leu Glu Thr Thr Met Arg Ser Pro Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Val Asp Gly Phe Gly Asp Val Gly Ala Leu 
        435                 440                 445             


Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu 
    450                 455                 460                 


Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu 
465                 470                 475                 480 


Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu 
                485                 490                 495     


Arg Arg Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp 
            500                 505                 510         


Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln 
        515                 520                 525             


Asp His Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly 
    530                 535                 540                 


Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp 
545                 550                 555                 560 


Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr 
                565                 570                 575     


Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala 
            580                 585                 590         


Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser 
        595                 600                 605             


Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro 
    610                 615                 620                 


Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser 
625                 630                 635                 640 


Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly 
                645                 650                 655     


Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr 
            660                 665                 670         


Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser 
        675                 680                 685             


Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys 
    690                 695                 700                 


Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys 
705                 710                 715                 720 


Thr Ser 
        


<210>  27
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Met Asp Asp Asn Glu Ala Glu Lys Leu Ile Arg Glu Ala Glu Glu Ala 
1               5                   10                  15      


Ala Lys Asp Ala Glu Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val 
            20                  25                  30          


Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Lys Glu Ala Ala Glu 
        35                  40                  45              


Glu Val Gln Arg Asn Pro Ser Ser Ser Asp Val Asn Glu Ala Leu His 
    50                  55                  60                  


Ser Ile Val Tyr Ala Ile Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala 
65                  70                  75                  80  


Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val 
                85                  90                  95      


Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro Ser Ser 
            100                 105                 110         


Arg Asn Val Glu His Ala Leu Met Arg Ile Val Leu Ala Ile Tyr Leu 
        115                 120                 125             


Ala Glu Glu Asn Leu Arg Glu Lys Lys Lys Gly Ser Val Val Ile Val 
    130                 135                 140                 


Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ser Gln Gln Thr Arg 
145                 150                 155                 160 


Gly Leu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn 
                165                 170                 175     


Gln Val Glu Gly Glu Val Gln Val Val Ser Thr Ala Thr Gln Ser Phe 
            180                 185                 190         


Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr His Gly Ala 
        195                 200                 205             


Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr Gln Met Tyr 
    210                 215                 220                 


Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro Gln Gly Ser 
225                 230                 235                 240 


Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val 
                245                 250                 255     


Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg 
            260                 265                 270         


Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala 
        275                 280                 285             


Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg 
    290                 295                 300                 


Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro 
305                 310                 315                 320 


Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro Ser Gly Ser Gly Gly 
                325                 330                 335     


Ser Gly Ser Ala Ser Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu 
            340                 345                 350         


Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu 
        355                 360                 365             


Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu 
    370                 375                 380                 


Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu 
385                 390                 395                 400 


Arg Arg Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp 
                405                 410                 415     


Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln 
            420                 425                 430         


Asp His Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly 
        435                 440                 445             


Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp 
    450                 455                 460                 


Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr 
465                 470                 475                 480 


Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala 
                485                 490                 495     


Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser 
            500                 505                 510         


Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro 
        515                 520                 525             


Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu Ala Ala Ile Ser Ser 
    530                 535                 540                 


Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly 
545                 550                 555                 560 


Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr 
                565                 570                 575     


Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser 
            580                 585                 590         


Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys 
        595                 600                 605             


Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys 
    610                 615                 620                 


Thr Ser 
625     


<210>  28
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Met Glu Leu Glu Glu Val Leu Lys Asp Leu Glu Glu Ala Leu Glu Arg 
1               5                   10                  15      


Leu Arg Asn Glu Glu Leu Arg Arg Leu Ile Glu Glu Ile Ala Glu Leu 
            20                  25                  30          


Leu Arg Arg Arg Asp Asp His Ser Ile Ile Tyr Met Ile Glu Ala Leu 
        35                  40                  45              


Ile Phe Val Ile Glu Ala Val Glu Arg Thr Gly Asp Glu Arg Ile Glu 
    50                  55                  60                  


Lys Leu Leu Glu Glu Leu Ile Lys Arg Ile Arg Asn Gly Asp Asp Asp 
65                  70                  75                  80  


Ser Ala Ile Met Arg Ile Val Leu Ala Val Tyr Leu Ile Glu Glu Asn 
                85                  90                  95      


Leu Arg Glu Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn 
            100                 105                 110         


Leu Ser Gly Asp Thr Ala Tyr Ser Gln Gln Thr Arg Gly Leu Glu Gly 
        115                 120                 125             


Cys Gln Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly 
    130                 135                 140                 


Glu Val Gln Val Val Ser Thr Ala Thr Gln Ser Phe Leu Ala Thr Ser 
145                 150                 155                 160 


Ile Asn Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr 
                165                 170                 175     


Ile Ala Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp 
            180                 185                 190         


Lys Asp Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr 
        195                 200                 205             


Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala 
    210                 215                 220                 


Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu 
225                 230                 235                 240 


Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu 
                245                 250                 255     


Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser 
            260                 265                 270         


Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu 
        275                 280                 285             


Glu Thr Thr Met Arg Ser Pro Ser Gly Ser Gly Gly Ser Gly Ser Ala 
    290                 295                 300                 


Ser Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg 
305                 310                 315                 320 


Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His 
                325                 330                 335     


Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg 
            340                 345                 350         


Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe 
        355                 360                 365             


Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys 
    370                 375                 380                 


Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala 
385                 390                 395                 400 


Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser 
                405                 410                 415     


His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val 
            420                 425                 430         


Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser 
        435                 440                 445             


Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu 
    450                 455                 460                 


Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu 
465                 470                 475                 480 


Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly 
                485                 490                 495     


Leu Arg Thr Phe Asp Gln Leu Ala Ala Ile Ser Ser Leu Pro Thr Pro 
            500                 505                 510         


Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp 
        515                 520                 525             


Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile 
    530                 535                 540                 


Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg 
545                 550                 555                 560 


Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly 
                565                 570                 575     


Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
            580                 585                 590 


<210>  29
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Met Tyr Ala Lys Glu Ala Ala Glu Phe Ala Arg Glu Ala Ala Glu Arg 
1               5                   10                  15      


Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Glu Arg Leu 
            20                  25                  30          


Ala Arg Arg Gly Ser Ser Glu His Ala Leu Met Arg Ile Val Leu Ala 
        35                  40                  45              


Ile Tyr Leu Ala Glu Glu Asn Leu Arg Glu Lys Lys Lys Gly Ser Val 
    50                  55                  60                  


Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ser Gln 
65                  70                  75                  80  


Gln Thr Arg Gly Leu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg 
                85                  90                  95      


Asp Lys Asn Gln Val Glu Gly Glu Val Gln Val Val Ser Thr Ala Thr 
            100                 105                 110         


Gln Ser Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr 
        115                 120                 125             


His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr 
    130                 135                 140                 


Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro 
145                 150                 155                 160 


Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu 
                165                 170                 175     


Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly 
            180                 185                 190         


Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys 
        195                 200                 205             


Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly 
    210                 215                 220                 


Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp 
225                 230                 235                 240 


Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro Ser Gly 
                245                 250                 255     


Ser Gly Gly Ser Gly Ser Ala Ser Gly Ser Gly Gly Phe Gly Asp Val 
            260                 265                 270         


Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu 
        275                 280                 285             


Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe 
    290                 295                 300                 


Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys 
305                 310                 315                 320 


Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met Val Glu Val 
                325                 330                 335     


Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu 
            340                 345                 350         


Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu 
        355                 360                 365             


Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr 
    370                 375                 380                 


Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe 
385                 390                 395                 400 


Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe 
                405                 410                 415     


Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala 
            420                 425                 430         


Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp 
        435                 440                 445             


Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu Ala Ala 
    450                 455                 460                 


Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr 
465                 470                 475                 480 


Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr 
                485                 490                 495     


Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp 
            500                 505                 510         


Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly 
        515                 520                 525             


Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu 
    530                 535                 540                 


Phe Phe Lys Thr Ser 
545                 


<210>  30
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Met Asp Ile Glu Lys Leu Cys Lys Lys Ala Glu Glu Glu Ala Lys Glu 
1               5                   10                  15      


Ala Gln Glu Lys Ala Asp Glu Leu Arg Gln Arg His Pro Asp Ser Gln 
            20                  25                  30          


Ala Ala Glu Asp Ala Glu Asp Leu Ala Asn Leu Ala Val Ala Ala Val 
        35                  40                  45              


Leu Thr Ala Cys Leu Leu Ala Gln Glu His Pro Asn Ala Asp Ile Ala 
    50                  55                  60                  


Lys Leu Cys Ile Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys 
65                  70                  75                  80  


Ala Ala Glu Leu Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp 
                85                  90                  95      


Ala Ile Lys Leu Ala Ser Gln Ala Ala Arg Ala Val Ile Leu Ala Ile 
            100                 105                 110         


Met Leu Ala Ala Glu Asn Pro Asn Ala Asp Ile Ala Lys Leu Cys Ile 
        115                 120                 125             


Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys Ala Ala Glu Leu 
    130                 135                 140                 


Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp Ala Ile Lys Leu 
145                 150                 155                 160 


Ala Ser Gln Ala Ala Glu Ala Val Glu Arg Ala Ile Trp Leu Ala Ala 
                165                 170                 175     


Glu Asn Pro Asn Ala Asp Ile Ala Lys Lys Cys Ile Lys Ala Ala Ser 
            180                 185                 190         


Glu Ala Ala Glu Glu Ala Ser Lys Ala Ala Glu Glu Ala Gln Arg His 
        195                 200                 205             


Pro Asp Ser Gln Lys Ala Arg Asp Glu Ile Lys Glu Ala Ser Gln Lys 
    210                 215                 220                 


Ala Glu Glu Val Lys Glu Arg Cys Lys Ser Ser Gly Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Ser Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu 
                245                 250                 255     


Ser Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys 
            260                 265                 270         


Gln Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
        275                 280                 285             


Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile 
    290                 295                 300                 


Asn Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile 
305                 310                 315                 320 


Ala Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys 
                325                 330                 335     


Asp Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro 
            340                 345                 350         


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
        355                 360                 365             


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
    370                 375                 380                 


Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu 
385                 390                 395                 400 


Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr 
                405                 410                 415     


Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu 
            420                 425                 430         


Thr Thr Met Arg Ser Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Val Asp Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg 
    450                 455                 460                 


Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His 
465                 470                 475                 480 


Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg 
                485                 490                 495     


Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe 
            500                 505                 510         


Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys 
        515                 520                 525             


Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala 
    530                 535                 540                 


Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser 
545                 550                 555                 560 


His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val 
                565                 570                 575     


Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser 
            580                 585                 590         


Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu 
        595                 600                 605             


Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu 
    610                 615                 620                 


Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly 
625                 630                 635                 640 


Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro 
                645                 650                 655     


Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp 
            660                 665                 670         


Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile 
        675                 680                 685             


Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg 
    690                 695                 700                 


Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly 
705                 710                 715                 720 


Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
                725                 730                 


<210>  31
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Met Asp Ile Glu Lys Leu Cys Lys Lys Ala Glu Glu Glu Ala Lys Glu 
1               5                   10                  15      


Ala Gln Glu Lys Ala Asp Glu Leu Arg Gln Arg His Pro Asp Ser Gln 
            20                  25                  30          


Ala Ala Glu Asp Ala Glu Asp Leu Ala Asn Leu Ala Val Ala Ala Val 
        35                  40                  45              


Leu Thr Ala Cys Leu Leu Ala Gln Glu His Pro Asn Ala Asp Ile Ala 
    50                  55                  60                  


Lys Leu Cys Ile Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys 
65                  70                  75                  80  


Ala Ala Glu Leu Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp 
                85                  90                  95      


Ala Ile Lys Leu Ala Ser Gln Ala Ala Arg Ala Val Ile Leu Ala Ile 
            100                 105                 110         


Met Leu Ala Ala Glu Asn Pro Asn Ala Asp Ile Ala Lys Leu Cys Ile 
        115                 120                 125             


Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys Ala Ala Glu Leu 
    130                 135                 140                 


Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp Ala Ile Lys Leu 
145                 150                 155                 160 


Ala Ser Gln Ala Ala Glu Ala Val Glu Arg Ala Ile Trp Leu Ala Ala 
                165                 170                 175     


Glu Asn Pro Asn Ala Asp Ile Ala Lys Lys Cys Ile Lys Ala Ala Ser 
            180                 185                 190         


Glu Ala Ala Glu Glu Ala Ser Lys Ala Ala Glu Glu Ala Gln Arg His 
        195                 200                 205             


Pro Asp Ser Gln Lys Ala Arg Asp Glu Ile Lys Glu Ala Ser Gln Lys 
    210                 215                 220                 


Ala Glu Glu Val Lys Glu Arg Cys Lys Ser Ser Gly Gly Gly Ser Lys 
225                 230                 235                 240 


Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp 
                245                 250                 255     


Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln Glu Thr 
            260                 265                 270         


Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile 
        275                 280                 285             


Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn Gly Val 
    290                 295                 300                 


Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro 
305                 310                 315                 320 


Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val 
                325                 330                 335     


Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys 
            340                 345                 350         


Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro 
        355                 360                 365             


Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro 
    370                 375                 380                 


Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala 
385                 390                 395                 400 


Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val 
                405                 410                 415     


Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met 
            420                 425                 430         


Arg Ser Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val 
        435                 440                 445             


Asp Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala 
    450                 455                 460                 


Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile 
465                 470                 475                 480 


Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr 
                485                 490                 495     


Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu 
            500                 505                 510         


His Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val 
        515                 520                 525             


Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys 
    530                 535                 540                 


Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln 
545                 550                 555                 560 


Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu 
                565                 570                 575     


Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly 
            580                 585                 590         


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp 
        595                 600                 605             


His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly 
    610                 615                 620                 


Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr 
625                 630                 635                 640 


Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile 
                645                 650                 655     


Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro 
            660                 665                 670         


Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln 
        675                 680                 685             


Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn 
    690                 695                 700                 


Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn 
705                 710                 715                 720 


Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
                725                 730     


<210>  32
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Met Asp Ile Glu Lys Leu Cys Lys Lys Ala Glu Glu Glu Ala Lys Glu 
1               5                   10                  15      


Ala Gln Glu Lys Ala Asp Glu Leu Arg Gln Arg His Pro Asp Ser Gln 
            20                  25                  30          


Ala Ala Glu Asp Ala Glu Asp Leu Ala Asn Leu Ala Val Ala Ala Val 
        35                  40                  45              


Leu Thr Ala Cys Leu Leu Ala Gln Glu His Pro Asn Ala Asp Ile Ala 
    50                  55                  60                  


Lys Leu Cys Ile Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys 
65                  70                  75                  80  


Ala Ala Glu Leu Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp 
                85                  90                  95      


Ala Ile Lys Leu Ala Ser Gln Ala Ala Arg Ala Val Ile Leu Ala Ile 
            100                 105                 110         


Met Leu Ala Ala Glu Asn Pro Asn Ala Asp Ile Ala Lys Leu Cys Ile 
        115                 120                 125             


Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys Ala Ala Glu Leu 
    130                 135                 140                 


Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp Ala Ile Lys Leu 
145                 150                 155                 160 


Ala Ser Gln Ala Ala Glu Ala Val Glu Arg Ala Ile Trp Leu Ala Ala 
                165                 170                 175     


Glu Asn Pro Asn Ala Asp Ile Ala Lys Lys Cys Ile Lys Ala Ala Ser 
            180                 185                 190         


Glu Ala Ala Glu Glu Ala Ser Lys Ala Ala Glu Glu Ala Gln Arg His 
        195                 200                 205             


Pro Asp Ser Gln Lys Ala Arg Asp Glu Ile Lys Glu Ala Ser Gln Lys 
    210                 215                 220                 


Ala Glu Glu Val Lys Glu Arg Cys Lys Ser Ser Gly Ser Lys Lys Lys 
225                 230                 235                 240 


Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala 
                245                 250                 255     


Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln Glu Thr Ser Gln 
            260                 265                 270         


Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser 
        275                 280                 285             


Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp 
    290                 295                 300                 


Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly 
305                 310                 315                 320 


Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp 
                325                 330                 335     


Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser 
            340                 345                 350         


Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg 
        355                 360                 365             


Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser 
    370                 375                 380                 


Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His 
385                 390                 395                 400 


Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys 
                405                 410                 415     


Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser 
            420                 425                 430         


Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val Asp Gly 
        435                 440                 445             


Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu 
    450                 455                 460                 


Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn 
465                 470                 475                 480 


Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser 
                485                 490                 495     


Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe 
            500                 505                 510         


Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala 
        515                 520                 525             


Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys Val 
    530                 535                 540                 


Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro 
545                 550                 555                 560 


Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile 
                565                 570                 575     


Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro 
            580                 585                 590         


Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly 
        595                 600                 605             


Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn 
    610                 615                 620                 


Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp 
625                 630                 635                 640 


Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val 
                645                 650                 655     


Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser 
            660                 665                 670         


Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala 
        675                 680                 685             


His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val 
    690                 695                 700                 


Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu 
705                 710                 715                 720 


Arg Lys Lys Leu Phe Phe Lys Thr Ser 
                725                 


<210>  33
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Met Asp Ile Glu Lys Leu Cys Lys Lys Ala Glu Glu Glu Ala Lys Glu 
1               5                   10                  15      


Ala Gln Glu Lys Ala Asp Glu Leu Arg Gln Arg His Pro Asp Ser Gln 
            20                  25                  30          


Ala Ala Glu Asp Ala Glu Asp Leu Ala Asn Leu Ala Val Ala Ala Val 
        35                  40                  45              


Leu Thr Ala Cys Leu Leu Ala Gln Glu His Pro Asn Ala Asp Ile Ala 
    50                  55                  60                  


Lys Leu Cys Ile Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys 
65                  70                  75                  80  


Ala Ala Glu Leu Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp 
                85                  90                  95      


Ala Ile Lys Leu Ala Ser Gln Ala Ala Arg Ala Val Ile Leu Ala Ile 
            100                 105                 110         


Met Leu Ala Ala Glu Asn Pro Asn Ala Asp Ile Ala Lys Leu Cys Ile 
        115                 120                 125             


Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys Ala Ala Glu Leu 
    130                 135                 140                 


Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp Ala Ile Lys Leu 
145                 150                 155                 160 


Ala Ser Gln Ala Ala Glu Ala Val Glu Arg Ala Ile Trp Leu Ala Ala 
                165                 170                 175     


Glu Asn Pro Asn Ala Asp Ile Ala Lys Lys Cys Ile Lys Ala Ala Ser 
            180                 185                 190         


Glu Ala Ala Glu Glu Ala Ser Lys Ala Ala Glu Glu Ala Gln Arg His 
        195                 200                 205             


Pro Asp Ser Gln Lys Ala Arg Asp Glu Ile Lys Glu Ala Ser Gln Lys 
    210                 215                 220                 


Ala Glu Glu Val Lys Glu Arg Cys Lys Ser Lys Lys Lys Gly Ser Val 
225                 230                 235                 240 


Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ala Gln 
                245                 250                 255     


Gln Thr Arg Gly Glu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg 
            260                 265                 270         


Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr 
        275                 280                 285             


Gln Thr Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr 
    290                 295                 300                 


His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr 
305                 310                 315                 320 


Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro 
                325                 330                 335     


Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu 
            340                 345                 350         


Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly 
        355                 360                 365             


Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys 
    370                 375                 380                 


Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly 
385                 390                 395                 400 


Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp 
                405                 410                 415     


Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val Asp Gly Phe Gly Asp 
        435                 440                 445             


Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile 
    450                 455                 460                 


Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val Asn 
465                 470                 475                 480 


Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp 
                485                 490                 495     


Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met Val Glu 
            500                 505                 510         


Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu Glu 
        515                 520                 525             


Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys Val Val Val Ile 
    530                 535                 540                 


Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala Val 
545                 550                 555                 560 


Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn Ile 
                565                 570                 575     


Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe 
            580                 585                 590         


Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu Val 
        595                 600                 605             


Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro 
    610                 615                 620                 


Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp 
625                 630                 635                 640 


Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser 
                645                 650                 655     


Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp 
            660                 665                 670         


Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser Glu 
        675                 680                 685             


Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val Lys 
    690                 695                 700                 


Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys 
705                 710                 715                 720 


Leu Phe Phe Lys Thr Ser 
                725     


<210>  34
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Met Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu Ile Glu Arg Ala Lys 
1               5                   10                  15      


Glu Ala Ala Glu Arg Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro 
            20                  25                  30          


Arg Val Arg Glu Leu Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala 
        35                  40                  45              


Ala Glu Glu Val Lys Arg Asp Pro Ser Ser Ser Asp Val Asn Glu Ala 
    50                  55                  60                  


Leu Lys Leu Ile Val Glu Ala Ile Glu Ala Ala Val Asp Ala Leu Glu 
65                  70                  75                  80  


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
                85                  90                  95      


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
            100                 105                 110         


Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser Ile Val Tyr Ala Ile 
        115                 120                 125             


Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro 
    130                 135                 140                 


Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala 
145                 150                 155                 160 


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala 
                165                 170                 175     


Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg 
            180                 185                 190         


Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu 
        195                 200                 205             


Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp Pro 
    210                 215                 220                 


Ser Gly Trp Leu Asn His Ser Gly Ser Ala Ser Gly Ser Gly Gly Phe 
225                 230                 235                 240 


Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala 
                245                 250                 255     


Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn 
            260                 265                 270         


Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn 
        275                 280                 285             


Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met 
    290                 295                 300                 


Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu 
305                 310                 315                 320 


Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys Val Val 
                325                 330                 335     


Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly 
            340                 345                 350         


Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val 
        355                 360                 365             


Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys 
    370                 375                 380                 


Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe 
385                 390                 395                 400 


Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro 
                405                 410                 415     


Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln 
            420                 425                 430         


Leu Ala Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser 
        435                 440                 445             


Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly 
    450                 455                 460                 


Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His 
465                 470                 475                 480 


Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser 
                485                 490                 495     


Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg 
            500                 505                 510         


Lys Lys Leu Phe Phe Lys Thr Ser 
        515                 520 


<210>  35
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Met Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu Ile Glu Arg Ala Lys 
1               5                   10                  15      


Glu Ala Ala Glu Arg Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro 
            20                  25                  30          


Arg Val Arg Glu Leu Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala 
        35                  40                  45              


Ala Glu Glu Val Lys Arg Asp Pro Ser Ser Ser Asp Val Asn Glu Ala 
    50                  55                  60                  


Leu Lys Leu Ile Val Glu Ala Ile Glu Ala Ala Val Asp Ala Leu Glu 
65                  70                  75                  80  


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
                85                  90                  95      


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
            100                 105                 110         


Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser Ile Val Tyr Ala Ile 
        115                 120                 125             


Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro 
    130                 135                 140                 


Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala 
145                 150                 155                 160 


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala 
                165                 170                 175     


Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg 
            180                 185                 190         


Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu 
        195                 200                 205             


Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp Pro 
    210                 215                 220                 


Ser Gly Trp Leu Asn His Ser Gly Ser Ala Ser Gly Ser Gly Gly Phe 
225                 230                 235                 240 


Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala 
                245                 250                 255     


Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn 
            260                 265                 270         


Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn 
        275                 280                 285             


Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met 
    290                 295                 300                 


Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu 
305                 310                 315                 320 


Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys Val Val 
                325                 330                 335     


Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly 
            340                 345                 350         


Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val 
        355                 360                 365             


Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys 
    370                 375                 380                 


Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe 
385                 390                 395                 400 


Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro 
                405                 410                 415     


Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln 
            420                 425                 430         


Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser 
        435                 440                 445             


Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly 
    450                 455                 460                 


Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His 
465                 470                 475                 480 


Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser 
                485                 490                 495     


Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg 
            500                 505                 510         


Lys Lys Leu Phe Phe Lys Thr Ser 
        515                 520 


<210>  36
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Met Asp Asp Asn Glu Ala Glu Lys Leu Ile Arg Glu Ala Glu Glu Ala 
1               5                   10                  15      


Ala Lys Asp Ala Glu Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val 
            20                  25                  30          


Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Lys Glu Ala Ala Glu 
        35                  40                  45              


Glu Val Gln Arg Asn Pro Ser Ser Ser Asp Val Asn Glu Ala Leu His 
    50                  55                  60                  


Ser Ile Val Tyr Ala Ile Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala 
65                  70                  75                  80  


Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val 
                85                  90                  95      


Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro Ser Ser 
            100                 105                 110         


Arg Asn Val Glu His Ala Leu Met Arg Ile Val Leu Ala Ile Tyr Leu 
        115                 120                 125             


Ala Glu Glu Asn Leu Arg Glu Ser Gly Ser Ala Ser Gly Ser Gly Gly 
    130                 135                 140                 


Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu 
145                 150                 155                 160 


Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn 
                165                 170                 175     


Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser 
            180                 185                 190         


Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe 
        195                 200                 205             


Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala 
    210                 215                 220                 


Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys Val 
225                 230                 235                 240 


Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro 
                245                 250                 255     


Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile 
            260                 265                 270         


Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro 
        275                 280                 285             


Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly 
    290                 295                 300                 


Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn 
305                 310                 315                 320 


Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp 
                325                 330                 335     


Gln Leu Ala Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val 
            340                 345                 350         


Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser 
        355                 360                 365             


Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala 
    370                 375                 380                 


His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val 
385                 390                 395                 400 


Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu 
                405                 410                 415     


Arg Lys Lys Leu Phe Phe Lys Thr Ser 
            420                 425 


<210>  37
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Met Glu Leu Glu Glu Val Leu Lys Asp Leu Glu Glu Ala Leu Glu Arg 
1               5                   10                  15      


Leu Arg Asn Glu Glu Leu Arg Arg Leu Ile Glu Glu Ile Ala Glu Leu 
            20                  25                  30          


Leu Arg Arg Arg Asp Asp His Ser Ile Ile Tyr Met Ile Glu Ala Leu 
        35                  40                  45              


Ile Phe Val Ile Glu Ala Val Glu Arg Thr Gly Asp Glu Arg Ile Glu 
    50                  55                  60                  


Lys Leu Leu Glu Glu Leu Ile Lys Arg Ile Arg Asn Gly Asp Asp Asp 
65                  70                  75                  80  


Ser Ala Ile Met Arg Ile Val Leu Ala Val Tyr Leu Ile Glu Glu Asn 
                85                  90                  95      


Leu Arg Glu Ser Gly Ser Ala Ser Gly Ser Gly Gly Phe Gly Asp Val 
            100                 105                 110         


Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu 
        115                 120                 125             


Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe 
    130                 135                 140                 


Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys 
145                 150                 155                 160 


Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met Val Glu Val 
                165                 170                 175     


Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu 
            180                 185                 190         


Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu 
        195                 200                 205             


Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr 
    210                 215                 220                 


Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe 
225                 230                 235                 240 


Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe 
                245                 250                 255     


Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala 
            260                 265                 270         


Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp 
        275                 280                 285             


Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu Ala Ala 
    290                 295                 300                 


Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr 
305                 310                 315                 320 


Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr 
                325                 330                 335     


Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp 
            340                 345                 350         


Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly 
        355                 360                 365             


Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu 
    370                 375                 380                 


Phe Phe Lys Thr Ser 
385                 


<210>  38
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Met Tyr Ala Lys Glu Ala Ala Glu Phe Ala Arg Glu Ala Ala Glu Arg 
1               5                   10                  15      


Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Glu Arg Leu 
            20                  25                  30          


Ala Arg Arg Gly Ser Ser Glu His Ala Leu Met Arg Ile Val Leu Ala 
        35                  40                  45              


Ile Tyr Leu Ala Glu Glu Asn Leu Arg Glu Ser Gly Ser Ala Ser Gly 
    50                  55                  60                  


Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn 
65                  70                  75                  80  


Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu 
                85                  90                  95      


Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg 
            100                 105                 110         


Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser 
        115                 120                 125             


Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met 
    130                 135                 140                 


Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp 
145                 150                 155                 160 


Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu 
                165                 170                 175     


Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val 
            180                 185                 190         


Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly 
        195                 200                 205             


Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys 
    210                 215                 220                 


Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro 
225                 230                 235                 240 


Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg 
                245                 250                 255     


Thr Phe Asp Gln Leu Ala Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp 
            260                 265                 270         


Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp 
        275                 280                 285             


Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu 
    290                 295                 300                 


Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala 
305                 310                 315                 320 


Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe 
                325                 330                 335     


Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
            340                 345             


<210>  39
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Met Asp Ile Glu Lys Leu Cys Lys Lys Ala Glu Glu Glu Ala Lys Glu 
1               5                   10                  15      


Ala Gln Glu Lys Ala Asp Glu Leu Arg Gln Arg His Pro Asp Ser Gln 
            20                  25                  30          


Ala Ala Glu Asp Ala Glu Asp Leu Ala Asn Leu Ala Val Ala Ala Val 
        35                  40                  45              


Leu Thr Ala Cys Leu Leu Ala Gln Glu His Pro Asn Ala Asp Ile Ala 
    50                  55                  60                  


Lys Leu Cys Ile Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys 
65                  70                  75                  80  


Ala Ala Glu Leu Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp 
                85                  90                  95      


Ala Ile Lys Leu Ala Ser Gln Ala Ala Arg Ala Val Ile Leu Ala Ile 
            100                 105                 110         


Met Leu Ala Ala Glu Asn Pro Asn Ala Asp Ile Ala Lys Leu Cys Ile 
        115                 120                 125             


Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys Ala Ala Glu Leu 
    130                 135                 140                 


Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp Ala Ile Lys Leu 
145                 150                 155                 160 


Ala Ser Gln Ala Ala Glu Ala Val Glu Arg Ala Ile Trp Leu Ala Ala 
                165                 170                 175     


Glu Asn Pro Asn Ala Asp Ile Ala Lys Lys Cys Ile Lys Ala Ala Ser 
            180                 185                 190         


Glu Ala Ala Glu Glu Ala Ser Lys Ala Ala Glu Glu Ala Gln Arg His 
        195                 200                 205             


Pro Asp Ser Gln Lys Ala Arg Asp Glu Ile Lys Glu Ala Ser Gln Lys 
    210                 215                 220                 


Ala Glu Glu Val Lys Glu Arg Cys Lys Ser Gly Ser Ala Ser Gly Ser 
225                 230                 235                 240 


Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala 
                245                 250                 255     


Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile 
            260                 265                 270         


Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr 
        275                 280                 285             


Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu 
    290                 295                 300                 


His Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val 
305                 310                 315                 320 


Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys 
                325                 330                 335     


Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln 
            340                 345                 350         


Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu 
        355                 360                 365             


Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly 
    370                 375                 380                 


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp 
385                 390                 395                 400 


His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly 
                405                 410                 415     


Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr 
            420                 425                 430         


Phe Asp Gln Leu Ala Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile 
        435                 440                 445             


Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro 
    450                 455                 460                 


Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln 
465                 470                 475                 480 


Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn 
                485                 490                 495     


Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn 
            500                 505                 510         


Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
        515                 520             


<210>  40
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Met Asp Ile Glu Lys Leu Cys Lys Lys Ala Glu Glu Glu Ala Lys Glu 
1               5                   10                  15      


Ala Gln Glu Lys Ala Asp Glu Leu Arg Gln Arg His Pro Asp Ser Gln 
            20                  25                  30          


Ala Ala Glu Asp Ala Glu Asp Leu Ala Asn Leu Ala Val Ala Ala Val 
        35                  40                  45              


Leu Thr Ala Cys Leu Leu Ala Gln Glu His Pro Asn Ala Asp Ile Ala 
    50                  55                  60                  


Lys Leu Cys Ile Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys 
65                  70                  75                  80  


Ala Ala Glu Leu Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp 
                85                  90                  95      


Ala Ile Lys Leu Ala Ser Gln Ala Ala Arg Ala Val Ile Leu Ala Ile 
            100                 105                 110         


Met Leu Ala Ala Glu Asn Pro Asn Ala Asp Ile Ala Lys Leu Cys Ile 
        115                 120                 125             


Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys Ala Ala Glu Leu 
    130                 135                 140                 


Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp Ala Ile Lys Leu 
145                 150                 155                 160 


Ala Ser Gln Ala Ala Glu Ala Val Glu Arg Ala Ile Trp Leu Ala Ala 
                165                 170                 175     


Glu Asn Pro Asn Ala Asp Ile Ala Lys Lys Cys Ile Lys Ala Ala Ser 
            180                 185                 190         


Glu Ala Ala Glu Glu Ala Ser Lys Ala Ala Glu Glu Ala Gln Arg His 
        195                 200                 205             


Pro Asp Ser Gln Lys Ala Arg Asp Glu Ile Lys Glu Ala Ser Gln Lys 
    210                 215                 220                 


Ala Glu Glu Val Lys Glu Arg Cys Lys Ser Gly Ser Ala Ser Gly Ser 
225                 230                 235                 240 


Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala 
                245                 250                 255     


Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile 
            260                 265                 270         


Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr 
        275                 280                 285             


Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu 
    290                 295                 300                 


His Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val 
305                 310                 315                 320 


Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys 
                325                 330                 335     


Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln 
            340                 345                 350         


Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu 
        355                 360                 365             


Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly 
    370                 375                 380                 


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp 
385                 390                 395                 400 


His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly 
                405                 410                 415     


Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr 
            420                 425                 430         


Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile 
        435                 440                 445             


Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro 
    450                 455                 460                 


Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln 
465                 470                 475                 480 


Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn 
                485                 490                 495     


Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn 
            500                 505                 510         


Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
        515                 520             


<210>  41
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  NON_CONS
<222>  (20)..(21)
<223>  Residues at these positions can be separated by a scFV_hinge 
       region of unknown length

<400>  41

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val 
            20                  25                  30          


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        35                  40                  45              


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    50                  55                  60                  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
65                  70                  75                  80  


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ala 
                85                  90                  95      


Ser Gly Ser Ala Ser Gly Ser Ala Ser Met Lys Lys Lys Gly Ser Val 
            100                 105                 110         


Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ser Gln 
        115                 120                 125             


Gln Thr Arg Gly Leu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg 
    130                 135                 140                 


Asp Lys Asn Gln Val Glu Gly Glu Val Gln Val Val Ser Thr Ala Thr 
145                 150                 155                 160 


Gln Ser Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr 
                165                 170                 175     


His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr 
            180                 185                 190         


Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro 
        195                 200                 205             


Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu 
    210                 215                 220                 


Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly 
225                 230                 235                 240 


Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys 
                245                 250                 255     


Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly 
            260                 265                 270         


Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp 
        275                 280                 285             


Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro 
    290                 295                 300         


<210>  42
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  42

Met Thr Arg Thr Glu Ile Ile Arg Glu Leu Glu Arg Ser Leu Arg Glu 
1               5                   10                  15      


Gln Glu Glu Leu Ala Lys Arg Leu Lys Glu Leu Leu Arg Glu Leu Glu 
            20                  25                  30          


Arg Leu Gln Arg Glu Gly Ser Ser Asp Glu Asp Val Arg Glu Leu Leu 
        35                  40                  45              


Arg Glu Ile Lys Glu Leu Val Glu Glu Ile Glu Lys Leu Ala Arg Glu 
    50                  55                  60                  


Gln Lys Tyr Leu Val Glu Glu Leu Lys Arg Gln Asp Gly Ser Ala Ser 
65                  70                  75                  80  


Gly Ser Ala Ser Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg 
                85                  90                  95      


Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ser Gln Gln Thr Arg Gly Leu 
            100                 105                 110         


Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val 
        115                 120                 125             


Glu Gly Glu Val Gln Val Val Ser Thr Ala Thr Gln Ser Phe Leu Ala 
    130                 135                 140                 


Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr 
145                 150                 155                 160 


Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn 
                165                 170                 175     


Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser 
            180                 185                 190         


Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg 
        195                 200                 205             


His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser 
    210                 215                 220                 


Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly 
225                 230                 235                 240 


Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala 
                245                 250                 255     


Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu 
            260                 265                 270         


Ser Leu Glu Thr Thr Met Arg Ser Pro 
        275                 280     


<210>  43
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Met Thr Glu Asp Glu Ile Arg Lys Leu Arg Lys Leu Leu Glu Glu Ala 
1               5                   10                  15      


Glu Lys Lys Leu Lys Lys Leu Glu Asp Lys Thr Arg Arg Ser Glu Glu 
            20                  25                  30          


Ile Ser Lys Thr Asp Asp Asp Pro Lys Ala Gln Ser Leu Gln Leu Ile 
        35                  40                  45              


Ala Glu Ser Leu Met Leu Ile Ala Glu Ser Leu Leu Ile Ile Ala Ile 
    50                  55                  60                  


Ser Leu Leu Leu Ser Ser Arg Asn Gly Ser Ala Ser Gly Ser Ala Ser 
65                  70                  75                  80  


Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
                85                  90                  95      


Gly Asp Thr Ala Tyr Ser Gln Gln Thr Arg Gly Leu Glu Gly Cys Gln 
            100                 105                 110         


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        115                 120                 125             


Gln Val Val Ser Thr Ala Thr Gln Ser Phe Leu Ala Thr Ser Ile Asn 
    130                 135                 140                 


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
145                 150                 155                 160 


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
                165                 170                 175     


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            180                 185                 190         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        195                 200                 205             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    210                 215                 220                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys 
225                 230                 235                 240 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
                245                 250                 255     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            260                 265                 270         


Thr Met Arg Ser Pro 
        275         


<210>  44
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Met Thr Arg Arg Lys Gln Glu Met Lys Arg Leu Lys Lys Glu Met Glu 
1               5                   10                  15      


Lys Ile Arg Glu Glu Thr Glu Glu Val Lys Lys Glu Ile Glu Glu Ser 
            20                  25                  30          


Lys Lys Arg Pro Gln Ser Glu Ser Ala Lys Asn Leu Ile Leu Ile Met 
        35                  40                  45              


Gln Leu Leu Ile Asn Gln Ile Arg Leu Leu Ala Leu Gln Ile Arg Met 
    50                  55                  60                  


Leu Ala Leu Gln Leu Gln Glu Gly Ser Ala Ser Gly Ser Ala Ser Met 
65                  70                  75                  80  


Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser Gly 
                85                  90                  95      


Asp Thr Ala Tyr Ser Gln Gln Thr Arg Gly Leu Glu Gly Cys Gln Glu 
            100                 105                 110         


Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln 
        115                 120                 125             


Val Val Ser Thr Ala Thr Gln Ser Phe Leu Ala Thr Ser Ile Asn Gly 
    130                 135                 140                 


Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser 
145                 150                 155                 160 


Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp Leu 
                165                 170                 175     


Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr 
            180                 185                 190         


Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile 
        195                 200                 205             


Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg 
    210                 215                 220                 


Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro 
225                 230                 235                 240 


Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg Gly 
                245                 250                 255     


Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr Thr 
            260                 265                 270         


Met Arg Ser Pro 
        275     


<210>  45
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Met Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ser 
1               5                   10                  15      


Thr Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala Ser Thr Glu 
            20                  25                  30          


Glu Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu Asn Asn Arg 
        35                  40                  45              


Leu Ile Val Glu His Asn Ala Ile Ile Val Glu Asn Asn Arg Ile Ile 
    50                  55                  60                  


Ala Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys Gly Ser Ala Ser 
65                  70                  75                  80  


Gly Ser Ala Ser Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg 
                85                  90                  95      


Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ser Gln Gln Thr Arg Gly Leu 
            100                 105                 110         


Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val 
        115                 120                 125             


Glu Gly Glu Val Gln Val Val Ser Thr Ala Thr Gln Ser Phe Leu Ala 
    130                 135                 140                 


Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr 
145                 150                 155                 160 


Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn 
                165                 170                 175     


Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser 
            180                 185                 190         


Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg 
        195                 200                 205             


His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser 
    210                 215                 220                 


Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly 
225                 230                 235                 240 


Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala 
                245                 250                 255     


Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu 
            260                 265                 270         


Ser Leu Glu Thr Thr Met Arg Ser Pro 
        275                 280     


<210>  46
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  NON_CONS
<222>  (20)..(21)
<223>  Residues at these positions can be separated by a scFV_hinge 
       region of unknown length

<400>  46

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val 
            20                  25                  30          


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        35                  40                  45              


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    50                  55                  60                  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
65                  70                  75                  80  


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ala 
                85                  90                  95      


Ser Gly Ser Ala Ser Gly Ser Ala Ser Met Lys Lys Lys Gly Ser Val 
            100                 105                 110         


Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ser Gln 
        115                 120                 125             


Gln Thr Arg Gly Leu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg 
    130                 135                 140                 


Asp Lys Asn Gln Val Glu Gly Glu Val Gln Val Val Ser Thr Ala Thr 
145                 150                 155                 160 


Gln Ser Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr 
                165                 170                 175     


His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr 
            180                 185                 190         


Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro 
        195                 200                 205             


Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu 
    210                 215                 220                 


Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly 
225                 230                 235                 240 


Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys 
                245                 250                 255     


Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly 
            260                 265                 270         


Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp 
        275                 280                 285             


Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro Gly Ser 
    290                 295                 300                 


Ser Gly Ser Ser Gly Ser Ser Gly Gly Lys Lys Lys Gly Ser Val Val 
305                 310                 315                 320 


Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ser Gln Gln 
                325                 330                 335     


Thr Arg Gly Leu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg Asp 
            340                 345                 350         


Lys Asn Gln Val Glu Gly Glu Val Gln Val Val Ser Thr Ala Thr Gln 
        355                 360                 365             


Ser Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr His 
    370                 375                 380                 


Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr Gln 
385                 390                 395                 400 


Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro Gln 
                405                 410                 415     


Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr 
            420                 425                 430         


Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp 
        435                 440                 445             


Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly 
    450                 455                 460                 


Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Ile 
465                 470                 475                 480 


Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp Phe 
                485                 490                 495     


Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro 
            500                 505                 


<210>  47
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Met Leu Glu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
1               5                   10                  15      


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
            20                  25                  30          


Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro 
        35                  40                  45              


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
    50                  55                  60                  


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
                85                  90                  95      


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly 
            100                 105                 110         


Gly Gly Ser Gly Ser Gly Asn Pro Ala Met Pro Thr Ser Ser Gly Ser 
        115                 120                 125             


Glu Gly Asn Val Lys Leu Cys Ser Leu Glu Glu Ala Gln Arg Ile Trp 
    130                 135                 140                 


Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile Met Asp Lys Ser Ser Arg 
145                 150                 155                 160 


Thr Arg Leu Ala Leu Ile Ile Cys Asn Glu Glu Phe Asp Ser Ile Pro 
                165                 170                 175     


Arg Arg Thr Gly Ala Glu Val Asp Ile Thr Gly Met Thr Met Leu Leu 
            180                 185                 190         


Gln Asn Leu Gly Tyr Ser Val Asp Val Lys Lys Asn Leu Thr Ala Ser 
        195                 200                 205             


Asp Met Thr Thr Glu Leu Glu Ala Phe Ala His Arg Pro Glu His Lys 
    210                 215                 220                 


Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser His Gly Ile Arg Glu 
225                 230                 235                 240 


Gly Ile Cys Gly Lys Lys His Ser Glu Gln Val Pro Asp Ile Leu Gln 
                245                 250                 255     


Leu Asn Ala Ile Phe Asn Met Leu Asn Thr Lys Asn Cys Pro Ser Leu 
            260                 265                 270         


Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Asp Ser 
        275                 280                 285             


Pro Gly Val Val Trp Phe Lys Asp Ser Val Gly Val Ser Gly Asn Leu 
    290                 295                 300                 


Ser Leu Pro Thr Thr Glu Glu Phe Glu Asp Asp Ala Ile Lys Lys Ala 
305                 310                 315                 320 


His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro Asp Asn 
                325                 330                 335     


Val Ser Trp Arg His Pro Thr Met Gly Ser Val Phe Ile Gly Arg Leu 
            340                 345                 350         


Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp Val Glu Glu Ile 
        355                 360                 365             


Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp Gly Arg Ala Gln 
    370                 375                 380                 


Met Pro Thr Thr Glu Arg Val Thr Leu Thr Arg Cys Phe Tyr Leu Phe 
385                 390                 395                 400 


Pro Gly His 
            


<210>  48
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Met Leu Glu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
1               5                   10                  15      


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
            20                  25                  30          


Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro 
        35                  40                  45              


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
    50                  55                  60                  


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
                85                  90                  95      


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly 
            100                 105                 110         


Gly Gly Ser Gly Ser Gly Glu Ala Gly Pro Pro Glu Ser Gly Glu Ser 
        115                 120                 125             


Thr Asp Ala Leu Lys Leu Cys Pro His Glu Glu Phe Leu Arg Leu Cys 
    130                 135                 140                 


Lys Glu Arg Ala Glu Glu Ile Tyr Pro Ile Lys Glu Arg Asn Asn Arg 
145                 150                 155                 160 


Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr Glu Phe Asp His Leu Pro 
                165                 170                 175     


Pro Arg Asn Gly Ala Asp Phe Asp Ile Thr Gly Met Lys Glu Leu Leu 
            180                 185                 190         


Glu Gly Leu Asp Tyr Ser Val Asp Val Glu Glu Asn Leu Thr Ala Arg 
        195                 200                 205             


Asp Met Glu Ser Ala Leu Arg Ala Phe Ala Thr Arg Pro Glu His Lys 
    210                 215                 220                 


Ser Ser Asp Ser Thr Phe Leu Val Leu Met Ser His Gly Ile Leu Glu 
225                 230                 235                 240 


Gly Ile Cys Gly Thr Val His Asp Glu Lys Lys Pro Asp Val Leu Leu 
                245                 250                 255     


Tyr Asp Thr Ile Phe Gln Ile Phe Asn Asn Arg Asn Cys Leu Ser Leu 
            260                 265                 270         


Lys Asp Lys Pro Lys Val Ile Ile Val Gln Ala Cys Arg Gly Ala Asn 
        275                 280                 285             


Arg Gly Glu Leu Trp Val Arg Asp Ser Pro Ala Ser Leu Glu Val Ala 
    290                 295                 300                 


Ser Ser Gln Ser Ser Glu Asn Leu Glu Glu Asp Ala Val Tyr Lys Thr 
305                 310                 315                 320 


His Val Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro His Asn 
                325                 330                 335     


Val Ser Trp Arg Asp Ser Thr Met Gly Ser Ile Phe Ile Thr Gln Leu 
            340                 345                 350         


Ile Thr Cys Phe Gln Lys Tyr Ser Trp Cys Cys His Leu Glu Glu Val 
        355                 360                 365             


Phe Arg Lys Val Gln Gln Ser Phe Glu Thr Pro Arg Ala Lys Ala Gln 
    370                 375                 380                 


Met Pro Thr Ile Glu Arg Leu Ser Met Thr Arg Tyr Phe Tyr Leu Phe 
385                 390                 395                 400 


Pro Gly Asn 
            


<210>  49
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Met Leu Glu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
1               5                   10                  15      


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
            20                  25                  30          


Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro 
        35                  40                  45              


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
    50                  55                  60                  


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
                85                  90                  95      


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly 
            100                 105                 110         


Gly Gly Ser Gly Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser 
        115                 120                 125             


Ile Lys Asn Leu Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp 
    130                 135                 140                 


Ser Gly Ile Ser Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met 
145                 150                 155                 160 


Gly Leu Cys Ile Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly 
                165                 170                 175     


Met Thr Ser Arg Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu 
            180                 185                 190         


Thr Phe Arg Asn Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr 
        195                 200                 205             


Arg Glu Glu Ile Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His 
    210                 215                 220                 


Ser Lys Arg Ser Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu 
225                 230                 235                 240 


Gly Ile Ile Phe Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr 
                245                 250                 255     


Asn Phe Phe Arg Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys 
            260                 265                 270         


Leu Phe Ile Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile 
        275                 280                 285             


Glu Thr Asp Ser Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro 
    290                 295                 300                 


Val Glu Ala Asp Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr 
305                 310                 315                 320 


Ser Trp Arg Asn Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys 
                325                 330                 335     


Ala Met Leu Lys Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu 
            340                 345                 350         


Thr Arg Val Asn Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe 
        355                 360                 365             


Asp Ala Thr Phe His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met 
    370                 375                 380                 


Leu Thr Lys Glu Leu Tyr Phe Tyr His 
385                 390             


<210>  50
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Met Leu Glu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
1               5                   10                  15      


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
            20                  25                  30          


Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro 
        35                  40                  45              


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
    50                  55                  60                  


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
                85                  90                  95      


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly 
            100                 105                 110         


Gly Gly Ser Gly Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser 
        115                 120                 125             


Ile Lys Asn Leu Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp 
    130                 135                 140                 


Ser Gly Ile Ser Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met 
145                 150                 155                 160 


Gly Leu Cys Ile Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly 
                165                 170                 175     


Met Thr Ser Arg Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu 
            180                 185                 190         


Thr Phe Arg Asn Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr 
        195                 200                 205             


Arg Glu Glu Ile Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His 
    210                 215                 220                 


Ser Lys Arg Ser Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu 
225                 230                 235                 240 


Gly Ile Ile Phe Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr 
                245                 250                 255     


Asn Phe Phe Arg Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys 
            260                 265                 270         


Leu Phe Ile Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile 
        275                 280                 285             


Glu Thr Asp Ser Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro 
    290                 295                 300                 


Val Glu Ala Asp Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr 
305                 310                 315                 320 


Ser Trp Arg Asn Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys 
                325                 330                 335     


Ala Met Leu Lys Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu 
            340                 345                 350         


Thr Arg Val Asn Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe 
        355                 360                 365             


Asp Ala Thr Phe His Ala Lys Lys Gln Ile Pro Gly Cys Phe Asn Phe 
    370                 375                 380                 


Leu Thr Lys Glu Leu Tyr Phe Tyr His 
385                 390             


<210>  51
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Met Ser Cys Val Lys Leu Trp Pro Ser Gly Ala Pro Ala Pro Leu Val 
1               5                   10                  15      


Ser Ile Glu Glu Leu Glu Asn Gln Glu Leu Val Gly Lys Gly Gly Phe 
            20                  25                  30          


Gly Thr Val Phe Arg Ala Gln His Arg Lys Trp Gly Tyr Asp Val Ala 
        35                  40                  45              


Val Lys Ile Val Asn Ser Lys Ala Ile Ser Arg Glu Val Lys Ala Met 
    50                  55                  60                  


Ala Ser Leu Asp Asn Glu Phe Val Leu Arg Leu Glu Gly Val Ile Glu 
65                  70                  75                  80  


Lys Val Asn Trp Asp Gln Asp Pro Lys Pro Ala Leu Val Thr Lys Phe 
                85                  90                  95      


Met Glu Asn Gly Ser Leu Ser Gly Leu Leu Gln Ser Gln Cys Pro Arg 
            100                 105                 110         


Pro Trp Pro Leu Leu Cys Arg Leu Leu Lys Glu Val Val Leu Gly Met 
        115                 120                 125             


Phe Tyr Leu His Asp Gln Asn Pro Val Leu Leu His Arg Asp Leu Lys 
    130                 135                 140                 


Pro Ser Asn Val Leu Leu Asp Pro Glu Leu His Val Lys Leu Ala Asp 
145                 150                 155                 160 


Phe Gly Leu Ser Thr Phe Gln Gly Gly Ser Gln Ser Gly Thr Gly Ser 
                165                 170                 175     


Gly Glu Pro Gly Gly Thr Leu Gly Tyr Leu Ala Pro Glu Leu Phe Val 
            180                 185                 190         


Asn Val Asn Arg Lys Ala Ser Thr Ala Ser Asp Val Tyr Ser Phe Gly 
        195                 200                 205             


Ile Leu Met Trp Ala Val Leu Ala Gly Arg Glu Val Glu Leu Pro Thr 
    210                 215                 220                 


Glu Pro Ser Leu Val Tyr Glu Ala Val Cys Asn Arg Gln Asn Arg Pro 
225                 230                 235                 240 


Ser Leu Ala Glu Leu Pro Gln Ala Gly Pro Glu Thr Pro Gly Leu Glu 
                245                 250                 255     


Gly Leu Lys Glu Leu Met Gln Leu Cys Trp Ser Ser Glu Pro Lys Asp 
            260                 265                 270         


Arg Pro Ser Phe Gln Glu Cys Leu Pro Lys Thr Asp Glu Val Phe Gln 
        275                 280                 285             


Met Val Glu Asn Asn Met Asn Ala Ala Val Ser Thr Val Lys Asp Phe 
    290                 295                 300                 


Leu Ser Gln Leu Arg Ser Ser Asn Arg Arg Phe Ser Ile Pro Glu Ser 
305                 310                 315                 320 


Gly Gln Gly Gly Thr Glu Met Asp Gly Phe Arg Arg Thr Ile Glu Asn 
                325                 330                 335     


Gln His Ser Arg Asn Asp Val Met Val Ser Glu Trp Leu Asn Lys Leu 
            340                 345                 350         


Asn Leu Glu Glu Pro Pro Ser Ser Val Pro Lys Lys Cys Pro Ser Leu 
        355                 360                 365             


Thr Lys Arg Ser Arg Ala Gln Glu Glu Gln Val Pro Gln Ala Trp Thr 
    370                 375                 380                 


Ala Gly Thr Ser Ser Asp Ser Met Ala Gln Pro Pro Gln Thr Pro Glu 
385                 390                 395                 400 


Thr Ser Thr Phe Arg Asn Gln Met Pro Ser Pro Thr Ser Thr Gly Thr 
                405                 410                 415     


Pro Ser Pro Gly Pro Arg Gly Asn Gln Gly Ala Glu Arg Gln Gly Met 
            420                 425                 430         


Asn Trp Ser Cys Arg Thr Pro Glu Pro Asn Pro Val Thr Gly Arg Pro 
        435                 440                 445             


Leu Val Asn Ile Tyr Asn Met Leu Glu Gly Val Gln Val Glu Thr Ile 
    450                 455                 460                 


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
465                 470                 475                 480 


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser 
                485                 490                 495     


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
            500                 505                 510         


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
        515                 520                 525             


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
    530                 535                 540                 


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
545                 550                 555                 560 


Leu Lys Leu Glu Gly Gly Ser Gly Arg Leu Glu Gly Val Gln Val Glu 
                565                 570                 575     


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
            580                 585                 590         


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp 
        595                 600                 605             


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
    610                 615                 620                 


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
625                 630                 635                 640 


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
                645                 650                 655     


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
            660                 665                 670         


Glu Leu Leu Lys Leu Glu 
        675             


<210>  52
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Met Glu Asn Leu Lys His Ile Ile Thr Leu Gly Gln Val Ile His Lys 
1               5                   10                  15      


Arg Cys Glu Glu Met Lys Tyr Cys Lys Lys Gln Cys Arg Arg Leu Gly 
            20                  25                  30          


His Arg Val Leu Gly Leu Ile Lys Pro Leu Glu Met Leu Gln Asp Gln 
        35                  40                  45              


Gly Lys Arg Ser Val Pro Ser Glu Lys Leu Thr Thr Ala Met Asn Arg 
    50                  55                  60                  


Phe Lys Ala Ala Leu Glu Glu Ala Asn Gly Glu Ile Glu Lys Phe Ser 
65                  70                  75                  80  


Asn Arg Ser Asn Ile Cys Arg Phe Leu Thr Ala Ser Gln Asp Lys Ile 
                85                  90                  95      


Leu Phe Lys Asp Val Asn Arg Lys Leu Ser Asp Val Trp Lys Glu Leu 
            100                 105                 110         


Ser Leu Leu Leu Gln Val Glu Gln Arg Met Pro Val Ser Pro Ile Ser 
        115                 120                 125             


Gln Gly Ala Ser Trp Ala Gln Glu Asp Gln Gln Asp Ala Asp Glu Asp 
    130                 135                 140                 


Arg Arg Ala Phe Gln Met Leu Arg Arg Asp Asn Glu Lys Ile Glu Ala 
145                 150                 155                 160 


Ser Leu Arg Arg Leu Glu Ile Asn Met Lys Glu Ile Lys Glu Thr Leu 
                165                 170                 175     


Arg Gln Tyr Leu Pro Pro Lys Cys Met Gln Glu Ile Pro Gln Glu Gln 
            180                 185                 190         


Ile Lys Glu Ile Lys Lys Glu Gln Leu Ser Gly Ser Pro Trp Ile Leu 
        195                 200                 205             


Leu Arg Glu Asn Glu Val Ser Thr Leu Tyr Lys Gly Glu Tyr His Arg 
    210                 215                 220                 


Ala Pro Val Ala Ile Lys Val Phe Lys Lys Leu Gln Ala Gly Ser Ile 
225                 230                 235                 240 


Ala Ile Val Arg Gln Thr Phe Asn Lys Glu Ile Lys Thr Met Lys Lys 
                245                 250                 255     


Phe Glu Ser Pro Asn Ile Leu Arg Ile Phe Gly Ile Cys Ile Asp Glu 
            260                 265                 270         


Thr Val Thr Pro Pro Gln Phe Ser Ile Val Met Glu Tyr Cys Glu Leu 
        275                 280                 285             


Gly Thr Leu Arg Glu Leu Leu Asp Arg Glu Lys Asp Leu Thr Leu Gly 
    290                 295                 300                 


Lys Arg Met Val Leu Val Leu Gly Ala Ala Arg Gly Leu Tyr Arg Leu 
305                 310                 315                 320 


His His Ser Glu Ala Pro Glu Leu His Gly Lys Ile Arg Ser Ser Asn 
                325                 330                 335     


Phe Leu Val Thr Gln Gly Tyr Gln Val Lys Leu Ala Gly Phe Glu Leu 
            340                 345                 350         


Arg Lys Thr Gln Thr Ser Met Ser Leu Gly Thr Thr Arg Glu Lys Thr 
        355                 360                 365             


Asp Arg Val Lys Ser Thr Ala Tyr Leu Ser Pro Gln Glu Leu Glu Asp 
    370                 375                 380                 


Val Phe Tyr Gln Tyr Asp Val Lys Ser Glu Ile Tyr Ser Phe Gly Ile 
385                 390                 395                 400 


Val Leu Trp Glu Ile Ala Thr Gly Asp Ile Pro Phe Gln Gly Cys Asn 
                405                 410                 415     


Ser Glu Lys Ile Arg Lys Leu Val Ala Val Lys Arg Gln Gln Glu Pro 
            420                 425                 430         


Leu Gly Glu Asp Cys Pro Ser Glu Leu Arg Glu Ile Ile Asp Glu Cys 
        435                 440                 445             


Arg Ala His Asp Pro Ser Val Arg Pro Ser Val Asp Glu Ile Leu Lys 
    450                 455                 460                 


Lys Leu Ser Thr Phe Ser Lys Gly Ser Met Leu Glu Gly Val Gln Val 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Glu Gly Gly Arg Thr Phe Pro Lys Arg Gly Gln 
                485                 490                 495     


Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val 
            500                 505                 510         


Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys 
        515                 520                 525             


Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val 
    530                 535                 540                 


Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala 
545                 550                 555                 560 


Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp 
                565                 570                 575     


Val Glu Leu Leu Lys Leu Glu Thr Gly Ser Gly Met Leu Glu Gly Val 
            580                 585                 590         


Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg 
        595                 600                 605             


Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys 
    610                 615                 620                 


Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu 
625                 630                 635                 640 


Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met 
                645                 650                 655     


Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr 
            660                 665                 670         


Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val 
        675                 680                 685             


Phe Asp Val Glu Leu Leu Lys Leu Glu 
    690                 695         


<210>  53
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Met Asp Ala Lys Ala Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu 
1               5                   10                  15      


Glu Lys Asp Ile Lys Thr Ser Tyr Ile Met Asp His Met Ile Ser Asp 
            20                  25                  30          


Gly Phe Leu Thr Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Thr 
        35                  40                  45              


Gln Gln Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 
    50                  55                  60                  


Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 
65                  70                  75                  80  


Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val Ser Ser 
                85                  90                  95      


Ser Ser Gly Lys Asp Ser Val Ser Gly Ile Thr Ser Gly Ser Met Leu 
            100                 105                 110         


Glu Gly Val Gln Val Glu Thr Ile Ser Pro Glu Gly Gly Arg Thr Phe 
        115                 120                 125             


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
    130                 135                 140                 


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
145                 150                 155                 160 


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
                165                 170                 175     


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
            180                 185                 190         


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
        195                 200                 205             


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Thr Gly Ser Gly 
    210                 215                 220                 


Met Leu Glu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
225                 230                 235                 240 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                245                 250                 255     


Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            260                 265                 270         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        275                 280                 285             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    290                 295                 300                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
305                 310                 315                 320 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
                325                 330                 


<210>  54
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  54

Met Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu Ile Glu Arg Ala Lys 
1               5                   10                  15      


Glu Ala Ala Glu Arg Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro 
            20                  25                  30          


Arg Val Arg Glu Leu Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala 
        35                  40                  45              


Ala Glu Glu Val Lys Arg Asp Pro Ser Ser Ser Asp Val Asn Glu Ala 
    50                  55                  60                  


Leu Lys Leu Ile Val Glu Ala Ile Glu Ala Ala Val Asp Ala Leu Glu 
65                  70                  75                  80  


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
                85                  90                  95      


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
            100                 105                 110         


Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser Ile Val Tyr Ala Ile 
        115                 120                 125             


Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro 
    130                 135                 140                 


Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala 
145                 150                 155                 160 


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala 
                165                 170                 175     


Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg 
            180                 185                 190         


Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu 
        195                 200                 205             


Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp Pro 
    210                 215                 220                 


Ser Gly Trp Leu Asn His Thr Gly Ser Gly Gly Gly Ser Gly Asn Pro 
225                 230                 235                 240 


Ala Met Pro Thr Ser Ser Gly Ser Glu Gly Asn Val Lys Leu Cys Ser 
                245                 250                 255     


Leu Glu Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser Ala Glu Ile Tyr 
            260                 265                 270         


Pro Ile Met Asp Lys Ser Ser Arg Thr Arg Leu Ala Leu Ile Ile Cys 
        275                 280                 285             


Asn Glu Glu Phe Asp Ser Ile Pro Arg Arg Thr Gly Ala Glu Val Asp 
    290                 295                 300                 


Ile Thr Gly Met Thr Met Leu Leu Gln Asn Leu Gly Tyr Ser Val Asp 
305                 310                 315                 320 


Val Lys Lys Asn Leu Thr Ala Ser Asp Met Thr Thr Glu Leu Glu Ala 
                325                 330                 335     


Phe Ala His Arg Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val 
            340                 345                 350         


Phe Met Ser His Gly Ile Arg Glu Gly Ile Cys Gly Lys Lys His Ser 
        355                 360                 365             


Glu Gln Val Pro Asp Ile Leu Gln Leu Asn Ala Ile Phe Asn Met Leu 
    370                 375                 380                 


Asn Thr Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile 
385                 390                 395                 400 


Ile Gln Ala Cys Arg Gly Asp Ser Pro Gly Val Val Trp Phe Lys Asp 
                405                 410                 415     


Ser Val Gly Val Ser Gly Asn Leu Ser Leu Pro Thr Thr Glu Glu Phe 
            420                 425                 430         


Glu Asp Asp Ala Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala 
        435                 440                 445             


Phe Cys Ser Ser Thr Pro Asp Asn Val Ser Trp Arg His Pro Thr Met 
    450                 455                 460                 


Gly Ser Val Phe Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala 
465                 470                 475                 480 


Cys Ser Cys Asp Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe 
                485                 490                 495     


Glu Gln Pro Asp Gly Arg Ala Gln Met Pro Thr Thr Glu Arg Val Thr 
            500                 505                 510         


Leu Thr Arg Cys Phe Tyr Leu Phe Pro Gly His 
        515                 520             


<210>  55
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  55

Met Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu Ile Glu Arg Ala Lys 
1               5                   10                  15      


Glu Ala Ala Glu Arg Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro 
            20                  25                  30          


Arg Val Arg Glu Leu Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala 
        35                  40                  45              


Ala Glu Glu Val Lys Arg Asp Pro Ser Ser Ser Asp Val Asn Glu Ala 
    50                  55                  60                  


Leu Lys Leu Ile Val Glu Ala Ile Glu Ala Ala Val Asp Ala Leu Glu 
65                  70                  75                  80  


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
                85                  90                  95      


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
            100                 105                 110         


Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser Ile Val Tyr Ala Ile 
        115                 120                 125             


Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro 
    130                 135                 140                 


Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala 
145                 150                 155                 160 


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala 
                165                 170                 175     


Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg 
            180                 185                 190         


Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu 
        195                 200                 205             


Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp Pro 
    210                 215                 220                 


Ser Gly Trp Leu Asn His Thr Gly Ser Gly Gly Gly Ser Gly Glu Ala 
225                 230                 235                 240 


Gly Pro Pro Glu Ser Gly Glu Ser Thr Asp Ala Leu Lys Leu Cys Pro 
                245                 250                 255     


His Glu Glu Phe Leu Arg Leu Cys Lys Glu Arg Ala Glu Glu Ile Tyr 
            260                 265                 270         


Pro Ile Lys Glu Arg Asn Asn Arg Thr Arg Leu Ala Leu Ile Ile Cys 
        275                 280                 285             


Asn Thr Glu Phe Asp His Leu Pro Pro Arg Asn Gly Ala Asp Phe Asp 
    290                 295                 300                 


Ile Thr Gly Met Lys Glu Leu Leu Glu Gly Leu Asp Tyr Ser Val Asp 
305                 310                 315                 320 


Val Glu Glu Asn Leu Thr Ala Arg Asp Met Glu Ser Ala Leu Arg Ala 
                325                 330                 335     


Phe Ala Thr Arg Pro Glu His Lys Ser Ser Asp Ser Thr Phe Leu Val 
            340                 345                 350         


Leu Met Ser His Gly Ile Leu Glu Gly Ile Cys Gly Thr Val His Asp 
        355                 360                 365             


Glu Lys Lys Pro Asp Val Leu Leu Tyr Asp Thr Ile Phe Gln Ile Phe 
    370                 375                 380                 


Asn Asn Arg Asn Cys Leu Ser Leu Lys Asp Lys Pro Lys Val Ile Ile 
385                 390                 395                 400 


Val Gln Ala Cys Arg Gly Ala Asn Arg Gly Glu Leu Trp Val Arg Asp 
                405                 410                 415     


Ser Pro Ala Ser Leu Glu Val Ala Ser Ser Gln Ser Ser Glu Asn Leu 
            420                 425                 430         


Glu Glu Asp Ala Val Tyr Lys Thr His Val Glu Lys Asp Phe Ile Ala 
        435                 440                 445             


Phe Cys Ser Ser Thr Pro His Asn Val Ser Trp Arg Asp Ser Thr Met 
    450                 455                 460                 


Gly Ser Ile Phe Ile Thr Gln Leu Ile Thr Cys Phe Gln Lys Tyr Ser 
465                 470                 475                 480 


Trp Cys Cys His Leu Glu Glu Val Phe Arg Lys Val Gln Gln Ser Phe 
                485                 490                 495     


Glu Thr Pro Arg Ala Lys Ala Gln Met Pro Thr Ile Glu Arg Leu Ser 
            500                 505                 510         


Met Thr Arg Tyr Phe Tyr Leu Phe Pro Gly Asn 
        515                 520             


<210>  56
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  56

Met Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu Ile Glu Arg Ala Lys 
1               5                   10                  15      


Glu Ala Ala Glu Arg Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro 
            20                  25                  30          


Arg Val Arg Glu Leu Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala 
        35                  40                  45              


Ala Glu Glu Val Lys Arg Asp Pro Ser Ser Ser Asp Val Asn Glu Ala 
    50                  55                  60                  


Leu Lys Leu Ile Val Glu Ala Ile Glu Ala Ala Val Asp Ala Leu Glu 
65                  70                  75                  80  


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
                85                  90                  95      


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
            100                 105                 110         


Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser Ile Val Tyr Ala Ile 
        115                 120                 125             


Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro 
    130                 135                 140                 


Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala 
145                 150                 155                 160 


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala 
                165                 170                 175     


Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg 
            180                 185                 190         


Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu 
        195                 200                 205             


Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp Pro 
    210                 215                 220                 


Ser Gly Trp Leu Asn His Thr Gly Ser Gly Gly Gly Ser Gly Met Glu 
225                 230                 235                 240 


Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu Glu Pro 
                245                 250                 255     


Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser Leu Asp 
            260                 265                 270         


Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile Ile Ile 
        275                 280                 285             


Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg Ser Gly 
    290                 295                 300                 


Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn Leu Lys 
305                 310                 315                 320 


Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile Val Glu 
                325                 330                 335     


Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser Ser Phe 
            340                 345                 350         


Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe Gly Thr 
        355                 360                 365             


Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg Gly Asp 
    370                 375                 380                 


Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile Gln Ala 
385                 390                 395                 400 


Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser Gly Val 
                405                 410                 415     


Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp Phe Leu 
            420                 425                 430         


Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn Ser Lys 
        435                 440                 445             


Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys Gln Tyr 
    450                 455                 460                 


Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn Arg Lys 
465                 470                 475                 480 


Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe His Ala 
                485                 490                 495     


Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu Leu Tyr 
            500                 505                 510         


Phe Tyr His 
        515 


<210>  57
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Met Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu Ile Glu Arg Ala Lys 
1               5                   10                  15      


Glu Ala Ala Glu Arg Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro 
            20                  25                  30          


Arg Val Arg Glu Leu Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala 
        35                  40                  45              


Ala Glu Glu Val Lys Arg Asp Pro Ser Ser Ser Asp Val Asn Glu Ala 
    50                  55                  60                  


Leu Lys Leu Ile Val Glu Ala Ile Glu Ala Ala Val Asp Ala Leu Glu 
65                  70                  75                  80  


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
                85                  90                  95      


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
            100                 105                 110         


Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser Ile Val Tyr Ala Ile 
        115                 120                 125             


Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro 
    130                 135                 140                 


Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala 
145                 150                 155                 160 


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala 
                165                 170                 175     


Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg 
            180                 185                 190         


Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu 
        195                 200                 205             


Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp Pro 
    210                 215                 220                 


Ser Gly Trp Leu Asn His Thr Gly Ser Gly Gly Gly Ser Gly Met Glu 
225                 230                 235                 240 


Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu Glu Pro 
                245                 250                 255     


Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser Leu Asp 
            260                 265                 270         


Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile Ile Ile 
        275                 280                 285             


Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg Ser Gly 
    290                 295                 300                 


Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn Leu Lys 
305                 310                 315                 320 


Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile Val Glu 
                325                 330                 335     


Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser Ser Phe 
            340                 345                 350         


Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe Gly Thr 
        355                 360                 365             


Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg Gly Asp 
    370                 375                 380                 


Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile Gln Ala 
385                 390                 395                 400 


Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser Gly Val 
                405                 410                 415     


Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp Phe Leu 
            420                 425                 430         


Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn Ser Lys 
        435                 440                 445             


Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys Gln Tyr 
    450                 455                 460                 


Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn Arg Lys 
465                 470                 475                 480 


Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe His Ala 
                485                 490                 495     


Lys Lys Gln Ile Pro Gly Cys Phe Asn Phe Leu Thr Lys Glu Leu Tyr 
            500                 505                 510         


Phe Tyr His 
        515 


<210>  58
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  58

Met Ser Cys Val Lys Leu Trp Pro Ser Gly Ala Pro Ala Pro Leu Val 
1               5                   10                  15      


Ser Ile Glu Glu Leu Glu Asn Gln Glu Leu Val Gly Lys Gly Gly Phe 
            20                  25                  30          


Gly Thr Val Phe Arg Ala Gln His Arg Lys Trp Gly Tyr Asp Val Ala 
        35                  40                  45              


Val Lys Ile Val Asn Ser Lys Ala Ile Ser Arg Glu Val Lys Ala Met 
    50                  55                  60                  


Ala Ser Leu Asp Asn Glu Phe Val Leu Arg Leu Glu Gly Val Ile Glu 
65                  70                  75                  80  


Lys Val Asn Trp Asp Gln Asp Pro Lys Pro Ala Leu Val Thr Lys Phe 
                85                  90                  95      


Met Glu Asn Gly Ser Leu Ser Gly Leu Leu Gln Ser Gln Cys Pro Arg 
            100                 105                 110         


Pro Trp Pro Leu Leu Cys Arg Leu Leu Lys Glu Val Val Leu Gly Met 
        115                 120                 125             


Phe Tyr Leu His Asp Gln Asn Pro Val Leu Leu His Arg Asp Leu Lys 
    130                 135                 140                 


Pro Ser Asn Val Leu Leu Asp Pro Glu Leu His Val Lys Leu Ala Asp 
145                 150                 155                 160 


Phe Gly Leu Ser Thr Phe Gln Gly Gly Ser Gln Ser Gly Thr Gly Ser 
                165                 170                 175     


Gly Glu Pro Gly Gly Thr Leu Gly Tyr Leu Ala Pro Glu Leu Phe Val 
            180                 185                 190         


Asn Val Asn Arg Lys Ala Ser Thr Ala Ser Asp Val Tyr Ser Phe Gly 
        195                 200                 205             


Ile Leu Met Trp Ala Val Leu Ala Gly Arg Glu Val Glu Leu Pro Thr 
    210                 215                 220                 


Glu Pro Ser Leu Val Tyr Glu Ala Val Cys Asn Arg Gln Asn Arg Pro 
225                 230                 235                 240 


Ser Leu Ala Glu Leu Pro Gln Ala Gly Pro Glu Thr Pro Gly Leu Glu 
                245                 250                 255     


Gly Leu Lys Glu Leu Met Gln Leu Cys Trp Ser Ser Glu Pro Lys Asp 
            260                 265                 270         


Arg Pro Ser Phe Gln Glu Cys Leu Pro Lys Thr Asp Glu Val Phe Gln 
        275                 280                 285             


Met Val Glu Asn Asn Met Asn Ala Ala Val Ser Thr Val Lys Asp Phe 
    290                 295                 300                 


Leu Ser Gln Leu Arg Ser Ser Asn Arg Arg Phe Ser Ile Pro Glu Ser 
305                 310                 315                 320 


Gly Gln Gly Gly Thr Glu Met Asp Gly Phe Arg Arg Thr Ile Glu Asn 
                325                 330                 335     


Gln His Ser Arg Asn Asp Val Met Val Ser Glu Trp Leu Asn Lys Leu 
            340                 345                 350         


Asn Leu Glu Glu Pro Pro Ser Ser Val Pro Lys Lys Cys Pro Ser Leu 
        355                 360                 365             


Thr Lys Arg Ser Arg Ala Gln Glu Glu Gln Val Pro Gln Ala Trp Thr 
    370                 375                 380                 


Ala Gly Thr Ser Ser Asp Ser Met Ala Gln Pro Pro Gln Thr Pro Glu 
385                 390                 395                 400 


Thr Ser Thr Phe Arg Asn Gln Met Pro Ser Pro Thr Ser Thr Gly Thr 
                405                 410                 415     


Pro Ser Pro Gly Pro Arg Gly Asn Gln Gly Ala Glu Arg Gln Gly Met 
            420                 425                 430         


Asn Trp Ser Cys Arg Thr Pro Glu Pro Asn Pro Val Thr Gly Arg Pro 
        435                 440                 445             


Leu Val Asn Ile Tyr Asn Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu 
    450                 455                 460                 


Ile Glu Arg Ala Lys Glu Ala Ala Glu Arg Ala Gln Glu Ala Ala Glu 
465                 470                 475                 480 


Arg Thr Gly Asp Pro Arg Val Arg Glu Leu Ala Arg Glu Leu Lys Arg 
                485                 490                 495     


Leu Ala Gln Glu Ala Ala Glu Glu Val Lys Arg Asp Pro Ser Ser Ser 
            500                 505                 510         


Asp Val Asn Glu Ala Leu Lys Leu Ile Val Glu Ala Ile Glu Ala Ala 
        515                 520                 525             


Val Asp Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg 
    530                 535                 540                 


Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu 
545                 550                 555                 560 


Val Gln Arg Asn Pro Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser 
                565                 570                 575     


Ile Val Tyr Ala Ile Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu 
            580                 585                 590         


Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg 
        595                 600                 605             


Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg 
    610                 615                 620                 


Asn Val Glu His Ala Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala 
625                 630                 635                 640 


Glu Glu Asn Leu Arg Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg 
                645                 650                 655     


Glu Lys Ala Arg Glu Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu 
            660                 665                 670         


Val Gln Arg Asp Pro Ser Gly Trp Leu Asn His 
        675                 680             


<210>  59
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Met Glu Asn Leu Lys His Ile Ile Thr Leu Gly Gln Val Ile His Lys 
1               5                   10                  15      


Arg Cys Glu Glu Met Lys Tyr Cys Lys Lys Gln Cys Arg Arg Leu Gly 
            20                  25                  30          


His Arg Val Leu Gly Leu Ile Lys Pro Leu Glu Met Leu Gln Asp Gln 
        35                  40                  45              


Gly Lys Arg Ser Val Pro Ser Glu Lys Leu Thr Thr Ala Met Asn Arg 
    50                  55                  60                  


Phe Lys Ala Ala Leu Glu Glu Ala Asn Gly Glu Ile Glu Lys Phe Ser 
65                  70                  75                  80  


Asn Arg Ser Asn Ile Cys Arg Phe Leu Thr Ala Ser Gln Asp Lys Ile 
                85                  90                  95      


Leu Phe Lys Asp Val Asn Arg Lys Leu Ser Asp Val Trp Lys Glu Leu 
            100                 105                 110         


Ser Leu Leu Leu Gln Val Glu Gln Arg Met Pro Val Ser Pro Ile Ser 
        115                 120                 125             


Gln Gly Ala Ser Trp Ala Gln Glu Asp Gln Gln Asp Ala Asp Glu Asp 
    130                 135                 140                 


Arg Arg Ala Phe Gln Met Leu Arg Arg Asp Asn Glu Lys Ile Glu Ala 
145                 150                 155                 160 


Ser Leu Arg Arg Leu Glu Ile Asn Met Lys Glu Ile Lys Glu Thr Leu 
                165                 170                 175     


Arg Gln Tyr Leu Pro Pro Lys Cys Met Gln Glu Ile Pro Gln Glu Gln 
            180                 185                 190         


Ile Lys Glu Ile Lys Lys Glu Gln Leu Ser Gly Ser Pro Trp Ile Leu 
        195                 200                 205             


Leu Arg Glu Asn Glu Val Ser Thr Leu Tyr Lys Gly Glu Tyr His Arg 
    210                 215                 220                 


Ala Pro Val Ala Ile Lys Val Phe Lys Lys Leu Gln Ala Gly Ser Ile 
225                 230                 235                 240 


Ala Ile Val Arg Gln Thr Phe Asn Lys Glu Ile Lys Thr Met Lys Lys 
                245                 250                 255     


Phe Glu Ser Pro Asn Ile Leu Arg Ile Phe Gly Ile Cys Ile Asp Glu 
            260                 265                 270         


Thr Val Thr Pro Pro Gln Phe Ser Ile Val Met Glu Tyr Cys Glu Leu 
        275                 280                 285             


Gly Thr Leu Arg Glu Leu Leu Asp Arg Glu Lys Asp Leu Thr Leu Gly 
    290                 295                 300                 


Lys Arg Met Val Leu Val Leu Gly Ala Ala Arg Gly Leu Tyr Arg Leu 
305                 310                 315                 320 


His His Ser Glu Ala Pro Glu Leu His Gly Lys Ile Arg Ser Ser Asn 
                325                 330                 335     


Phe Leu Val Thr Gln Gly Tyr Gln Val Lys Leu Ala Gly Phe Glu Leu 
            340                 345                 350         


Arg Lys Thr Gln Thr Ser Met Ser Leu Gly Thr Thr Arg Glu Lys Thr 
        355                 360                 365             


Asp Arg Val Lys Ser Thr Ala Tyr Leu Ser Pro Gln Glu Leu Glu Asp 
    370                 375                 380                 


Val Phe Tyr Gln Tyr Asp Val Lys Ser Glu Ile Tyr Ser Phe Gly Ile 
385                 390                 395                 400 


Val Leu Trp Glu Ile Ala Thr Gly Asp Ile Pro Phe Gln Gly Cys Asn 
                405                 410                 415     


Ser Glu Lys Ile Arg Lys Leu Val Ala Val Lys Arg Gln Gln Glu Pro 
            420                 425                 430         


Leu Gly Glu Asp Cys Pro Ser Glu Leu Arg Glu Ile Ile Asp Glu Cys 
        435                 440                 445             


Arg Ala His Asp Pro Ser Val Arg Pro Ser Val Asp Glu Ile Leu Lys 
    450                 455                 460                 


Lys Leu Ser Thr Phe Ser Lys Gly Ser Ser Ser Asp Glu Glu Glu Ala 
465                 470                 475                 480 


Arg Glu Leu Ile Glu Arg Ala Lys Glu Ala Ala Glu Arg Ala Gln Glu 
                485                 490                 495     


Ala Ala Glu Arg Thr Gly Asp Pro Arg Val Arg Glu Leu Ala Arg Glu 
            500                 505                 510         


Leu Lys Arg Leu Ala Gln Glu Ala Ala Glu Glu Val Lys Arg Asp Pro 
        515                 520                 525             


Ser Ser Ser Asp Val Asn Glu Ala Leu Lys Leu Ile Val Glu Ala Ile 
    530                 535                 540                 


Glu Ala Ala Val Asp Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro 
545                 550                 555                 560 


Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala 
                565                 570                 575     


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Ser Asp Val Asn Glu Ala 
            580                 585                 590         


Leu His Ser Ile Val Tyr Ala Ile Glu Ala Ala Ile Phe Ala Leu Glu 
        595                 600                 605             


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
    610                 615                 620                 


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
625                 630                 635                 640 


Ser Ser Arg Asn Val Glu His Ala Leu Met Arg Ile Val Leu Ala Ile 
                645                 650                 655     


Tyr Leu Ala Glu Glu Asn Leu Arg Glu Ala Glu Glu Ser Gly Asp Pro 
            660                 665                 670         


Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg Glu Ala Val Glu Arg 
        675                 680                 685             


Ala Glu Glu Val Gln Arg Asp Pro Ser Gly Trp Leu Asn His 
    690                 695                 700         


<210>  60
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  60

Met Asp Ala Lys Ala Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu 
1               5                   10                  15      


Glu Lys Asp Ile Lys Thr Ser Tyr Ile Met Asp His Met Ile Ser Asp 
            20                  25                  30          


Gly Phe Leu Thr Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Thr 
        35                  40                  45              


Gln Gln Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 
    50                  55                  60                  


Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 
65                  70                  75                  80  


Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val Ser Ser 
                85                  90                  95      


Ser Ser Gly Lys Asp Ser Val Ser Gly Ile Thr Ser Gly Ser Ser Ser 
            100                 105                 110         


Asp Glu Glu Glu Ala Arg Glu Leu Ile Glu Arg Ala Lys Glu Ala Ala 
        115                 120                 125             


Glu Arg Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro Arg Val Arg 
    130                 135                 140                 


Glu Leu Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala Ala Glu Glu 
145                 150                 155                 160 


Val Lys Arg Asp Pro Ser Ser Ser Asp Val Asn Glu Ala Leu Lys Leu 
                165                 170                 175     


Ile Val Glu Ala Ile Glu Ala Ala Val Asp Ala Leu Glu Ala Ala Glu 
            180                 185                 190         


Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg 
        195                 200                 205             


Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Ser 
    210                 215                 220                 


Asp Val Asn Glu Ala Leu His Ser Ile Val Tyr Ala Ile Glu Ala Ala 
225                 230                 235                 240 


Ile Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg 
                245                 250                 255     


Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu 
            260                 265                 270         


Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala Leu Met Arg 
        275                 280                 285             


Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg Glu Ala Glu 
    290                 295                 300                 


Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg 
305                 310                 315                 320 


Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp Pro Ser Gly Trp 
                325                 330                 335     


Leu Asn His 
            


<210>  61
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  61

Met Asp Ala Lys Ala Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu 
1               5                   10                  15      


Glu Lys Asp Ile Lys Thr Ser Tyr Ile Met Asp His Met Ile Ser Asp 
            20                  25                  30          


Gly Phe Leu Thr Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Thr 
        35                  40                  45              


Gln Gln Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 
    50                  55                  60                  


Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 
65                  70                  75                  80  


Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val Ser Ser 
                85                  90                  95      


Ser Ser Gly Lys Asp Ser Val Ser Gly Ile Thr Ser Gly Ser Met Lys 
            100                 105                 110         


Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp 
        115                 120                 125             


Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln Glu Met 
    130                 135                 140                 


Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile 
145                 150                 155                 160 


Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn Gly Val 
                165                 170                 175     


Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro 
            180                 185                 190         


Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val 
        195                 200                 205             


Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys 
    210                 215                 220                 


Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro 
225                 230                 235                 240 


Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro 
                245                 250                 255     


Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala 
            260                 265                 270         


Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val 
        275                 280                 285             


Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met 
    290                 295                 300                 


Arg Ser Pro Thr Gly Ser Gly Gly Gly Ser Ser Ser Asp Glu Glu Glu 
305                 310                 315                 320 


Ala Arg Glu Leu Ile Glu Arg Ala Lys Glu Ala Ala Glu Arg Ala Gln 
                325                 330                 335     


Glu Ala Ala Glu Arg Thr Gly Asp Pro Arg Val Arg Glu Leu Ala Arg 
            340                 345                 350         


Glu Leu Lys Arg Leu Ala Gln Glu Ala Ala Glu Glu Val Lys Arg Asp 
        355                 360                 365             


Pro Ser Ser Ser Asp Val Asn Glu Ala Leu Lys Leu Ile Val Glu Ala 
    370                 375                 380                 


Ile Glu Ala Ala Val Asp Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp 
385                 390                 395                 400 


Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu 
                405                 410                 415     


Ala Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Ser Asp Val Asn Glu 
            420                 425                 430         


Ala Leu His Ser Ile Val Tyr Ala Ile Glu Ala Ala Ile Phe Ala Leu 
        435                 440                 445             


Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg 
    450                 455                 460                 


Glu Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn 
465                 470                 475                 480 


Pro Ser Ser Arg Asn Val Glu His Ala Leu Met Arg Ile Val Leu Ala 
                485                 490                 495     


Ile Tyr Leu Ala Glu Glu Asn Leu Arg Glu Ala Glu Glu Ser Gly Asp 
            500                 505                 510         


Pro Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg Glu Ala Val Glu 
        515                 520                 525             


Arg Ala Glu Glu Val Gln Arg Asp Pro Ser Gly Trp Leu Asn His 
    530                 535                 540             


<210>  62
<211>  1355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  62

Met Ser Cys Val Lys Leu Trp Pro Ser Gly Ala Pro Ala Pro Leu Val 
1               5                   10                  15      


Ser Ile Glu Glu Leu Glu Asn Gln Glu Leu Val Gly Lys Gly Gly Phe 
            20                  25                  30          


Gly Thr Val Phe Arg Ala Gln His Arg Lys Trp Gly Tyr Asp Val Ala 
        35                  40                  45              


Val Lys Ile Val Asn Ser Lys Ala Ile Ser Arg Glu Val Lys Ala Met 
    50                  55                  60                  


Ala Ser Leu Asp Asn Glu Phe Val Leu Arg Leu Glu Gly Val Ile Glu 
65                  70                  75                  80  


Lys Val Asn Trp Asp Gln Asp Pro Lys Pro Ala Leu Val Thr Lys Phe 
                85                  90                  95      


Met Glu Asn Gly Ser Leu Ser Gly Leu Leu Gln Ser Gln Cys Pro Arg 
            100                 105                 110         


Pro Trp Pro Leu Leu Cys Arg Leu Leu Lys Glu Val Val Leu Gly Met 
        115                 120                 125             


Phe Tyr Leu His Asp Gln Asn Pro Val Leu Leu His Arg Asp Leu Lys 
    130                 135                 140                 


Pro Ser Asn Val Leu Leu Asp Pro Glu Leu His Val Lys Leu Ala Asp 
145                 150                 155                 160 


Phe Gly Leu Ser Thr Phe Gln Gly Gly Ser Gln Ser Gly Thr Gly Ser 
                165                 170                 175     


Gly Glu Pro Gly Gly Thr Leu Gly Tyr Leu Ala Pro Glu Leu Phe Val 
            180                 185                 190         


Asn Val Asn Arg Lys Ala Ser Thr Ala Ser Asp Val Tyr Ser Phe Gly 
        195                 200                 205             


Ile Leu Met Trp Ala Val Leu Ala Gly Arg Glu Val Glu Leu Pro Thr 
    210                 215                 220                 


Glu Pro Ser Leu Val Tyr Glu Ala Val Cys Asn Arg Gln Asn Arg Pro 
225                 230                 235                 240 


Ser Leu Ala Glu Leu Pro Gln Ala Gly Pro Glu Thr Pro Gly Leu Glu 
                245                 250                 255     


Gly Leu Lys Glu Leu Met Gln Leu Cys Trp Ser Ser Glu Pro Lys Asp 
            260                 265                 270         


Arg Pro Ser Phe Gln Glu Cys Leu Pro Lys Thr Asp Glu Val Phe Gln 
        275                 280                 285             


Met Val Glu Asn Asn Met Asn Ala Ala Val Ser Thr Val Lys Asp Phe 
    290                 295                 300                 


Leu Ser Gln Leu Arg Ser Ser Asn Arg Arg Phe Ser Ile Pro Glu Ser 
305                 310                 315                 320 


Gly Gln Gly Gly Thr Glu Met Asp Gly Phe Arg Arg Thr Ile Glu Asn 
                325                 330                 335     


Gln His Ser Arg Asn Asp Val Met Val Ser Glu Trp Leu Asn Lys Leu 
            340                 345                 350         


Asn Leu Glu Glu Pro Pro Ser Ser Val Pro Lys Lys Cys Pro Ser Leu 
        355                 360                 365             


Thr Lys Arg Ser Arg Ala Gln Glu Glu Gln Val Pro Gln Ala Trp Thr 
    370                 375                 380                 


Ala Gly Thr Ser Ser Asp Ser Met Ala Gln Pro Pro Gln Thr Pro Glu 
385                 390                 395                 400 


Thr Ser Thr Phe Arg Asn Gln Met Pro Ser Pro Thr Ser Thr Gly Thr 
                405                 410                 415     


Pro Ser Pro Gly Pro Arg Gly Asn Gln Gly Ala Glu Arg Gln Gly Met 
            420                 425                 430         


Asn Trp Ser Cys Arg Thr Pro Glu Pro Asn Pro Val Thr Gly Arg Pro 
        435                 440                 445             


Leu Val Asn Ile Tyr Asn Met Lys Lys Lys Gly Ser Val Val Ile Val 
    450                 455                 460                 


Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg 
465                 470                 475                 480 


Gly Glu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn 
                485                 490                 495     


Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe 
            500                 505                 510         


Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr His Gly Ala 
        515                 520                 525             


Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr Gln Met Tyr 
    530                 535                 540                 


Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro Gln Gly Ser 
545                 550                 555                 560 


Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val 
                565                 570                 575     


Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg 
            580                 585                 590         


Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala 
        595                 600                 605             


Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg 
    610                 615                 620                 


Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro 
625                 630                 635                 640 


Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro Gly Ser Gly Glu Gly 
                645                 650                 655     


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
            660                 665                 670         


Met Ser Cys Val Lys Leu Trp Pro Ser Gly Ala Pro Ala Pro Leu Val 
        675                 680                 685             


Ser Ile Glu Glu Leu Glu Asn Gln Glu Leu Val Gly Lys Gly Gly Phe 
    690                 695                 700                 


Gly Thr Val Phe Arg Ala Gln His Arg Lys Trp Gly Tyr Asp Val Ala 
705                 710                 715                 720 


Val Lys Ile Val Asn Ser Lys Ala Ile Ser Arg Glu Val Lys Ala Met 
                725                 730                 735     


Ala Ser Leu Asp Asn Glu Phe Val Leu Arg Leu Glu Gly Val Ile Glu 
            740                 745                 750         


Lys Val Asn Trp Asp Gln Asp Pro Lys Pro Ala Leu Val Thr Lys Phe 
        755                 760                 765             


Met Glu Asn Gly Ser Leu Ser Gly Leu Leu Gln Ser Gln Cys Pro Arg 
    770                 775                 780                 


Pro Trp Pro Leu Leu Cys Arg Leu Leu Lys Glu Val Val Leu Gly Met 
785                 790                 795                 800 


Phe Tyr Leu His Asp Gln Asn Pro Val Leu Leu His Arg Asp Leu Lys 
                805                 810                 815     


Pro Ser Asn Val Leu Leu Asp Pro Glu Leu His Val Lys Leu Ala Asp 
            820                 825                 830         


Phe Gly Leu Ser Thr Phe Gln Gly Gly Ser Gln Ser Gly Thr Gly Ser 
        835                 840                 845             


Gly Glu Pro Gly Gly Thr Leu Gly Tyr Leu Ala Pro Glu Leu Phe Val 
    850                 855                 860                 


Asn Val Asn Arg Lys Ala Ser Thr Ala Ser Asp Val Tyr Ser Phe Gly 
865                 870                 875                 880 


Ile Leu Met Trp Ala Val Leu Ala Gly Arg Glu Val Glu Leu Pro Thr 
                885                 890                 895     


Glu Pro Ser Leu Val Tyr Glu Ala Val Cys Asn Arg Gln Asn Arg Pro 
            900                 905                 910         


Ser Leu Ala Glu Leu Pro Gln Ala Gly Pro Glu Thr Pro Gly Leu Glu 
        915                 920                 925             


Gly Leu Lys Glu Leu Met Gln Leu Cys Trp Ser Ser Glu Pro Lys Asp 
    930                 935                 940                 


Arg Pro Ser Phe Gln Glu Cys Leu Pro Lys Thr Asp Glu Val Phe Gln 
945                 950                 955                 960 


Met Val Glu Asn Asn Met Asn Ala Ala Val Ser Thr Val Lys Asp Phe 
                965                 970                 975     


Leu Ser Gln Leu Arg Ser Ser Asn Arg Arg Phe Ser Ile Pro Glu Ser 
            980                 985                 990         


Gly Gln Gly Gly Thr Glu Met Asp  Gly Phe Arg Arg Thr  Ile Glu Asn 
        995                 1000                 1005             


Gln His  Ser Arg Asn Asp Val  Met Val Ser Glu Trp  Leu Asn Lys 
    1010                 1015                 1020             


Leu Asn  Leu Glu Glu Pro Pro  Ser Ser Val Pro Lys  Lys Cys Pro 
    1025                 1030                 1035             


Ser Leu  Thr Lys Arg Ser Arg  Ala Gln Glu Glu Gln  Val Pro Gln 
    1040                 1045                 1050             


Ala Trp  Thr Ala Gly Thr Ser  Ser Asp Ser Met Ala  Gln Pro Pro 
    1055                 1060                 1065             


Gln Thr  Pro Glu Thr Ser Thr  Phe Arg Asn Gln Met  Pro Ser Pro 
    1070                 1075                 1080             


Thr Ser  Thr Gly Thr Pro Ser  Pro Gly Pro Arg Gly  Asn Gln Gly 
    1085                 1090                 1095             


Ala Glu  Arg Gln Gly Met Asn  Trp Ser Cys Arg Thr  Pro Glu Pro 
    1100                 1105                 1110             


Asn Pro  Val Thr Gly Arg Pro  Leu Val Asn Ile Tyr  Asn Ser Ser 
    1115                 1120                 1125             


Asp Glu  Glu Glu Ala Arg Glu  Leu Ile Glu Arg Ala  Lys Glu Ala 
    1130                 1135                 1140             


Ala Glu  Arg Ala Gln Glu Ala  Ala Glu Arg Thr Gly  Asp Pro Arg 
    1145                 1150                 1155             


Val Arg  Glu Leu Ala Arg Glu  Leu Lys Arg Leu Ala  Gln Glu Ala 
    1160                 1165                 1170             


Ala Glu  Glu Val Lys Arg Asp  Pro Ser Ser Ser Asp  Val Asn Glu 
    1175                 1180                 1185             


Ala Leu  Lys Leu Ile Val Glu  Ala Ile Glu Ala Ala  Val Asp Ala 
    1190                 1195                 1200             


Leu Glu  Ala Ala Glu Arg Thr  Gly Asp Pro Glu Val  Arg Glu Leu 
    1205                 1210                 1215             


Ala Arg  Glu Leu Val Arg Leu  Ala Val Glu Ala Ala  Glu Glu Val 
    1220                 1225                 1230             


Gln Arg  Asn Pro Ser Ser Ser  Asp Val Asn Glu Ala  Leu His Ser 
    1235                 1240                 1245             


Ile Val  Tyr Ala Ile Glu Ala  Ala Ile Phe Ala Leu  Glu Ala Ala 
    1250                 1255                 1260             


Glu Arg  Thr Gly Asp Pro Glu  Val Arg Glu Leu Ala  Arg Glu Leu 
    1265                 1270                 1275             


Val Arg  Leu Ala Val Glu Ala  Ala Glu Glu Val Gln  Arg Asn Pro 
    1280                 1285                 1290             


Ser Ser  Arg Asn Val Glu His  Ala Leu Met Arg Ile  Val Leu Ala 
    1295                 1300                 1305             


Ile Tyr  Leu Ala Glu Glu Asn  Leu Arg Glu Ala Glu  Glu Ser Gly 
    1310                 1315                 1320             


Asp Pro  Glu Lys Arg Glu Lys  Ala Arg Glu Arg Val  Arg Glu Ala 
    1325                 1330                 1335             


Val Glu  Arg Ala Glu Glu Val  Gln Arg Asp Pro Ser  Gly Trp Leu 
    1340                 1345                 1350             


Asn His  
    1355 


<210>  63
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  63

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu 
    


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  64

Gly Gly Gly Gly Ser 
1               5   


<210>  65
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  65

Ser Glu Tyr Glu Ile Arg Lys Ala Leu Glu Glu Leu Lys Ala Ser Thr 
1               5                   10                  15      


Ala Glu Leu Lys Arg Ala Thr Ala Ser Leu Arg Ala Ser Thr Glu Glu 
            20                  25                  30          


Leu Lys Lys Asn Pro Ser Glu Asp Ala Leu Val Glu Asn Asn Arg Leu 
        35                  40                  45              


Ile Val Glu His Asn Ala Ile Ile Val Glu Asn Asn Arg Ile Ile Ala 
    50                  55                  60                  


Ala Val Leu Glu Leu Ile Val Arg Ala Ile Lys 
65                  70                  75  


<210>  66
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  66

Thr Arg Thr Glu Ile Ile Arg Glu Leu Glu Arg Ser Leu Arg Glu Gln 
1               5                   10                  15      


Glu Glu Leu Ala Lys Arg Leu Lys Glu Leu Leu Arg Glu Leu Glu Arg 
            20                  25                  30          


Leu Gln Arg Glu Gly Ser Ser Asp Glu Asp Val Arg Glu Leu Leu Arg 
        35                  40                  45              


Glu Ile Lys Glu Leu Val Glu Glu Ile Glu Lys Leu Ala Arg Glu Gln 
    50                  55                  60                  


Lys Tyr Leu Val Glu Glu Leu Lys Arg Gln Asp 
65                  70                  75  


<210>  67
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  67

Thr Arg Arg Lys Gln Glu Met Lys Arg Leu Lys Lys Glu Met Glu Lys 
1               5                   10                  15      


Ile Arg Glu Glu Thr Glu Glu Val Lys Lys Glu Ile Glu Glu Ser Lys 
            20                  25                  30          


Lys Arg Pro Gln Ser Glu Ser Ala Lys Asn Leu Ile Leu Ile Met Gln 
        35                  40                  45              


Leu Leu Ile Asn Gln Ile Arg Leu Leu Ala Leu Gln Ile Arg Met Leu 
    50                  55                  60                  


Ala Leu Gln Leu Gln Glu 
65                  70  


<210>  68
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  68

Thr Glu Asp Glu Ile Arg Lys Leu Arg Lys Leu Leu Glu Glu Ala Glu 
1               5                   10                  15      


Lys Lys Leu Lys Lys Leu Glu Asp Lys Thr Arg Arg Ser Glu Glu Ile 
            20                  25                  30          


Ser Lys Thr Asp Asp Asp Pro Lys Ala Gln Ser Leu Gln Leu Ile Ala 
        35                  40                  45              


Glu Ser Leu Met Leu Ile Ala Glu Ser Leu Leu Ile Ile Ala Ile Ser 
    50                  55                  60                  


Leu Leu Leu Ser Ser Arg Asn Gly 
65                  70          


<210>  69
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  69

Met Ala Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser Gly 
1               5                   10                  15      


Asp Thr Ala Tyr Ser Gln Gln Thr Arg Gly Leu Leu Gly Cys Ile Ile 
            20                  25                  30          


Thr Ser Ala Thr Gly Arg Asp Lys Asn Gln Val Asp Gly Glu Val Gln 
        35                  40                  45              


Val Leu Ser Thr Ala Thr Gln Ser Phe Leu Ala Thr Cys Val Asn Gly 
    50                  55                  60                  


Val Cys Trp Thr Val Tyr His Gly Ala Gly Ser Lys Thr Leu Ala Gly 
65                  70                  75                  80  


Pro Lys Gly Pro Ile Thr Gln Met Tyr Thr Asn Val Asp Gln Asp Leu 
                85                  90                  95      


Val Gly Trp Pro Ala Pro Pro Gly Ala Arg Ser Met Thr Pro Cys Thr 
            100                 105                 110         


Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile 
        115                 120                 125             


Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg 
    130                 135                 140                 


Pro Val Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro 
145                 150                 155                 160 


Ser Gly His Val Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly 
                165                 170                 175     


Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Met Glu Thr Thr 
            180                 185                 190         


Met Arg Ser Pro 
        195     


<210>  70
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  70

Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
1               5                   10                  15      


Gly Asp Thr Ala Tyr Ser Gln Gln Thr Arg Gly Leu Glu Gly Cys Gln 
            20                  25                  30          


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Val Val Ser Thr Ala Thr Gln Ser Phe Leu Ala Thr Ser Ile Asn 
    50                  55                  60                  


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
                85                  90                  95      


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro 
        195         


<210>  71
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  71

Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser Gly 
1               5                   10                  15      


Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln Glu 
            20                  25                  30          


Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln 
        35                  40                  45              


Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn Gly 
    50                  55                  60                  


Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser 
65                  70                  75                  80  


Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp Leu 
                85                  90                  95      


Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr 
            100                 105                 110         


Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile 
        115                 120                 125             


Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg 
    130                 135                 140                 


Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro 
145                 150                 155                 160 


Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg Gly 
                165                 170                 175     


Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr Thr 
            180                 185                 190         


Met Arg Ser Pro 
        195     


<210>  72
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  72

Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu Ile Glu Arg Ala Lys Glu 
1               5                   10                  15      


Ala Ala Glu Arg Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro Arg 
            20                  25                  30          


Val Arg Glu Leu Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala Ala 
        35                  40                  45              


Glu Glu Val Lys Arg Asp Pro Ser Ser Ser Asp Val Asn Glu Ala Leu 
    50                  55                  60                  


Lys Leu Ile Val Glu Ala Ile Glu Ala Ala Val Asp Ala Leu Glu Ala 
65                  70                  75                  80  


Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu 
                85                  90                  95      


Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro Ser 
            100                 105                 110         


Ser Ser Asp Val Asn Glu Ala Leu His Ser Ile Val Tyr Ala Ile Glu 
        115                 120                 125             


Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu 
    130                 135                 140                 


Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala Ala 
145                 150                 155                 160 


Glu Glu Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala Leu 
                165                 170                 175     


Met Arg Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg Glu 
            180                 185                 190         


Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu Arg 
        195                 200                 205             


Val Arg Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp Pro Ser 
    210                 215                 220                 


Gly Trp Leu Asn His 
225                 


<210>  73
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  73

Asp Ile Glu Lys Leu Cys Lys Lys Ala Glu Glu Glu Ala Lys Glu Ala 
1               5                   10                  15      


Gln Glu Lys Ala Asp Glu Leu Arg Gln Arg His Pro Asp Ser Gln Ala 
            20                  25                  30          


Ala Glu Asp Ala Glu Asp Leu Ala Asn Leu Ala Val Ala Ala Val Leu 
        35                  40                  45              


Thr Ala Cys Leu Leu Ala Gln Glu His Pro Asn Ala Asp Ile Ala Lys 
    50                  55                  60                  


Leu Cys Ile Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys Ala 
65                  70                  75                  80  


Ala Glu Leu Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp Ala 
                85                  90                  95      


Ile Lys Leu Ala Ser Gln Ala Ala Arg Ala Val Ile Leu Ala Ile Met 
            100                 105                 110         


Leu Ala Ala Glu Asn Pro Asn Ala Asp Ile Ala Lys Leu Cys Ile Lys 
        115                 120                 125             


Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys Ala Ala Glu Leu Ala 
    130                 135                 140                 


Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp Ala Ile Lys Leu Ala 
145                 150                 155                 160 


Ser Gln Ala Ala Glu Ala Val Glu Arg Ala Ile Trp Leu Ala Ala Glu 
                165                 170                 175     


Asn Pro Asn Ala Asp Ile Ala Lys Lys Cys Ile Lys Ala Ala Ser Glu 
            180                 185                 190         


Ala Ala Glu Glu Ala Ser Lys Ala Ala Glu Glu Ala Gln Arg His Pro 
        195                 200                 205             


Asp Ser Gln Lys Ala Arg Asp Glu Ile Lys Glu Ala Ser Gln Lys Ala 
    210                 215                 220                 


Glu Glu Val Lys Glu Arg Cys Lys Ser 
225                 230             


<210>  74
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  74

Gly Glu Leu Asp Glu Leu Val Tyr Leu Leu Asp Gly Pro Gly Tyr Asp 
1               5                   10                  15      


Pro Ile His Ser Asp Val Val Thr Arg Gly Gly Ser His Leu Phe Asn 
            20                  25                  30          


Phe 
    


<210>  75
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  75

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  76
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  76

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly 
            20  


<210>  77
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  77

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
    50                  55                  60                  


Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
65                  70                  75                  80  


Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
                85                  90              


<210>  78
<211>  586
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  78
cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg       60

cgtttgtcta tatgtgattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga      120

aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa      180

tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa      240

caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct      300

gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg      360

ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg      420

ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtgca      480

catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg      540

acgtggtttt cctttgaaaa acacgatgat aagcttgcca caaccc                     586


<210>  79
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  80
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
            20                  25                  30          


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        35                  40                  45              


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
    50                  55                  60                  


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
65                  70                  75                  80  


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
                85                  90                  95      


Ala Ala Tyr Arg Ser 
            100     


<210>  81
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Tyr Asn Glu Lys Ser Asn Gly Thr Ile 
        35                  40                  45              


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
    50                  55                  60                  


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
65                  70                  75                  80  


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
                85                  90                  95      


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            100                 105                 110         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        115                 120                 125             


Arg Asp Phe Ala Ala Tyr Arg Ser 
    130                 135     


<210>  82
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Trp Lys His Leu Cys Pro Ser Pro Leu 
        35                  40                  45              


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
    50                  55                  60                  


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
65                  70                  75                  80  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                85                  90                  95      


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            100                 105                 110         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        115                 120             


<210>  83
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Tyr Asn Glu Lys Ser Asn Gly Thr Ile 
        35                  40                  45              


Ile His Val Lys Gly Glu Glu 
    50                  55  


<210>  84
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Tyr Asn Glu Lys Ser Asn Gly Thr Ile 
        35                  40                  45              


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
    50                  55                  60                  


Pro Ser Lys Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
65                  70                  75                  80  


<210>  85
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Pro Cys Gly Leu Ser Ala Leu Ile Met Cys Pro Lys Gly Met Val 
1               5                   10                  15      


Ala Val Val Val Ala Val Asp Asp Gly Asp Ser Gln Ala Leu Ala Gly 
            20                  25                  30          


Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn 
        35                  40                  45              


Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
    50                  55                  60                  


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
65                  70                  75                  80  


Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr 
                85                  90                  95      


Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr 
            100                 105                 110         


Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile 
        115                 120                 125             


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
    130                 135                 140                 


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
145                 150                 155                 160 


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        195                 200                 205             


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    210                 215                 220                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230                 


<210>  86
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  87
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  88
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  89
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  90
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  91
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Met 
                165             


<210>  92
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  93
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210>  94
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  94

Gln Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys 
1               5                   10                  15      


Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly 
            20                  25                  30          


Asp Ala Ala Arg 
        35      


<210>  95
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  95

Asp Asp Asn Glu Ala Glu Lys Leu Ile Arg Glu Ala Glu Glu Ala Ala 
1               5                   10                  15      


Lys Asp Ala Glu Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg 
            20                  25                  30          


Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Lys Glu Ala Ala Glu Glu 
        35                  40                  45              


Val Gln Arg Asn Pro Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser 
    50                  55                  60                  


Ile Val Tyr Ala Ile Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu 
65                  70                  75                  80  


Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg 
                85                  90                  95      


Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg 
            100                 105                 110         


Asn Val Glu His Ala Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala 
        115                 120                 125             


Glu Glu Asn Leu Arg Glu 
    130                 


<210>  96
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  96

Glu Glu Arg Glu Leu Ala Arg Glu Leu Glu Arg Leu Ala Lys Glu Ala 
1               5                   10                  15      


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Ser Asp Val Asn Glu Ala 
            20                  25                  30          


Leu His Ser Ile Glu Tyr Ala Arg Glu Ala Ala Glu Phe Ala Arg Glu 
        35                  40                  45              


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
    50                  55                  60                  


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
65                  70                  75                  80  


Ser Ser Arg Asn Val Glu His Ala Leu Met Arg Ile Val Leu Ala Ile 
                85                  90                  95      


Tyr Leu Ala Glu Glu Asn Leu Arg Glu 
            100                 105 


<210>  97
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  97

Asp Glu Asn Glu Ala Glu His Ser Arg Arg Tyr Ala Lys Glu Ala Ala 
1               5                   10                  15      


Glu Phe Ala Arg Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg 
            20                  25                  30          


Glu Leu Ala Arg Glu Leu Glu Arg Leu Ala Arg Glu Ala Ala Glu Glu 
        35                  40                  45              


Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala Leu Met Arg 
    50                  55                  60                  


Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg Glu 
65                  70                  75              


<210>  98
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  98

Asp Glu Asn Glu Leu Glu His Ile Arg Arg Tyr Leu Lys Glu Ile Leu 
1               5                   10                  15      


Glu Phe Val Arg Glu Val Val Glu Arg Thr Gly Asp Glu His Ile Arg 
            20                  25                  30          


Arg Leu Leu Glu Glu Leu Glu Arg Leu Val Lys Lys Val Ile Glu Glu 
        35                  40                  45              


Leu Lys Arg Arg Pro Asp Leu His His Asn Glu His Ala Phe Met Arg 
    50                  55                  60                  


Leu Val Leu Ala Val Tyr Leu Ala Glu Glu Asn Leu Arg Glu 
65                  70                  75              


<210>  99
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  99

Asp Glu Asn Glu Leu Glu His Ile Arg Arg Tyr Leu Lys Glu Val Leu 
1               5                   10                  15      


Glu Phe Val Arg Glu Ile Leu Glu Arg Thr Gly Asp Glu Glu Val Lys 
            20                  25                  30          


Lys Leu Ile Glu Glu Leu Glu Arg Leu Val Lys Lys Ile Glu Glu Glu 
        35                  40                  45              


Leu Lys Arg Asp Pro Arg Arg His His Asn Glu His Ala Val Met Arg 
    50                  55                  60                  


Leu Val Leu Ala Val Tyr Leu Leu Glu Glu Asn Leu Arg Glu 
65                  70                  75              


<210>  100
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  100

Asp Glu Glu Glu Leu His Lys Arg Val Glu Glu Leu Trp Lys Glu Leu 
1               5                   10                  15      


His Glu Leu Val Arg Arg His Ser His Asp Ser Asp Leu Asn Glu Leu 
            20                  25                  30          


Leu His Ile Ile Glu Tyr Leu Arg Glu Val Leu Glu Phe Val Arg Glu 
        35                  40                  45              


Val Leu Glu Arg Thr Gly Asp Glu His Ile Lys Arg Leu Leu His Glu 
    50                  55                  60                  


Leu Val Lys Arg Ile Val Glu Thr Ile Glu Glu Leu Lys Arg Asn Ser 
65                  70                  75                  80  


His His Ser Asn Asn Glu His Ala Val Met Arg Ile Val Leu Ala Val 
                85                  90                  95      


Tyr Leu Ala Glu Glu Asn Leu Arg Glu 
            100                 105 


<210>  101
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  101

Asp Glu Glu Glu Leu Glu Arg Arg Leu Glu Glu Leu Trp Arg Arg Ile 
1               5                   10                  15      


Lys Glu Arg Val Glu Arg His Ser His Asp Ser Asp Leu Asn Glu Leu 
            20                  25                  30          


Leu His Ile Ile Glu Tyr Leu Arg Glu Val Val Glu Phe Val Arg Glu 
        35                  40                  45              


Val Val Glu Arg Thr Gly Asp Glu His Ile Lys Arg Leu Leu Leu Glu 
    50                  55                  60                  


Leu Ile Arg Glu Ile Val Glu Val Ile Glu Lys Leu Glu Arg Asn Leu 
65                  70                  75                  80  


His Asp Ser Asn Asn Glu His Ala Val Met Arg Ile Val Leu Ala Val 
                85                  90                  95      


Tyr Leu Ala Glu Glu Asn Leu Arg Glu 
            100                 105 


<210>  102
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  102

Glu Val Glu Glu Val Leu Lys Asp Leu Glu Glu Ala Ile Glu Arg Leu 
1               5                   10                  15      


His Asp His Glu Ile Asn Arg Leu Ala Lys Glu Val Leu Lys Ile Leu 
            20                  25                  30          


Arg Lys Arg Asp Asp His Ser Ile Ile Tyr Ala Val Glu Val Met Ile 
        35                  40                  45              


Phe Val Ile Glu Val Leu Glu Arg Thr Gly Asp Glu Lys Val Arg Glu 
    50                  55                  60                  


Leu Ile Arg Glu Leu Ala Glu Ile Ile Arg Arg Lys Gly Gly Thr Asp 
65                  70                  75                  80  


Gly Ala Val Met Arg Leu Val Leu Ala Ile Tyr Leu Leu Glu Glu Asn 
                85                  90                  95      


Leu Arg Glu 
            


<210>  103
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  103

Glu Leu Glu Glu Val Leu Lys Asp Leu Glu Glu Ala Leu Glu Arg Leu 
1               5                   10                  15      


Arg Asn Glu Glu Leu Arg Arg Leu Ile Glu Glu Ile Ala Glu Leu Leu 
            20                  25                  30          


Arg Arg Arg Asp Asp His Ser Ile Ile Tyr Met Ile Glu Ala Leu Ile 
        35                  40                  45              


Phe Val Ile Glu Ala Val Glu Arg Thr Gly Asp Glu Arg Ile Glu Lys 
    50                  55                  60                  


Leu Leu Glu Glu Leu Ile Lys Arg Ile Arg Asn Gly Asp Asp Asp Ser 
65                  70                  75                  80  


Ala Ile Met Arg Ile Val Leu Ala Val Tyr Leu Ile Glu Glu Asn Leu 
                85                  90                  95      


Arg Glu 
        


<210>  104
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  104

Glu Ala Glu Glu Ala Ala Lys Asp Ala Glu Glu Ala Ala Glu Arg Leu 
1               5                   10                  15      


His Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala 
            20                  25                  30          


Lys Glu Thr Thr His Glu Asp Gly Leu His Ser Ile Val Tyr Ala Ile 
        35                  40                  45              


Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro 
    50                  55                  60                  


Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Arg Asn Gly 
65                  70                  75                  80  


Asp His Ser Gly Ala Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala 
                85                  90                  95      


Glu Glu Asn Leu Arg Glu 
            100         


<210>  105
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  105

Glu Ala Glu Glu Ala Ala Lys Asp Ala Glu Glu Ala Ala Glu Arg Leu 
1               5                   10                  15      


His Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala 
            20                  25                  30          


Lys Glu Arg Asp Asp His Ser Ile Val Tyr Ala Ile Glu Ala Ala Ile 
        35                  40                  45              


Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu 
    50                  55                  60                  


Leu Ala Arg Glu Leu Val Arg Leu Ala Arg Glu Gly Asp His Ser Ser 
65                  70                  75                  80  


Ala Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu 
                85                  90                  95      


Arg Glu 
        


<210>  106
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  106

Asp Asp Asn Glu Ala Glu Lys Leu Ile Arg Glu Ala Glu Glu Val Leu 
1               5                   10                  15      


Lys Asp Ile Glu Glu Ile Leu Glu Arg Leu His Asp Glu Glu Ile Ile 
            20                  25                  30          


Arg Leu Val Glu Glu Val Gln Lys Ile Leu Lys Glu Leu Leu Glu Arg 
        35                  40                  45              


Val His Lys His Pro His Asp Ser Asp Leu Asn Glu Leu Leu His Ile 
    50                  55                  60                  


Ile Phe Tyr Met Met Glu Val Leu Ile Phe Val Leu Glu Val Leu Glu 
65                  70                  75                  80  


Arg Thr Gly Asp Glu Glu Ile Arg Lys Leu Val Trp His Ile Val Arg 
                85                  90                  95      


Ile Ile Leu Glu Ile Leu Glu Glu Leu Arg Arg Asn Pro Lys His Ser 
            100                 105                 110         


Asn Asn Glu His Ala Leu Met Arg Leu Leu Leu Ala Ile Tyr Leu Leu 
        115                 120                 125             


Glu Glu Asn Leu Arg Glu 
    130                 


<210>  107
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  107

Glu Ala Glu Glu Ala Ala Lys Asp Ala Glu Glu Ala Ala Glu Arg Leu 
1               5                   10                  15      


His Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala 
            20                  25                  30          


Lys Glu Val Asp Asp His Ser Ile Val Tyr Ala Ile Glu Ala Ala Ile 
        35                  40                  45              


Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu 
    50                  55                  60                  


Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val 
65                  70                  75                  80  


Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala Leu Met Arg Ile 
                85                  90                  95      


Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg Glu 
            100                 105                 


<210>  108
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  108

Glu Phe Glu Glu Val Leu Lys Asp Leu Glu Glu Val Val Glu Arg Leu 
1               5                   10                  15      


His Asn Glu Glu Ile Arg Arg Leu Leu Glu Arg Leu Ile Glu Leu Leu 
            20                  25                  30          


Arg Arg Val Arg Asp His Ser Phe Ile Tyr Leu Val Glu Ala Val Ile 
        35                  40                  45              


Phe Val Leu Glu Val Leu Glu Arg Thr Gly Asp His Arg Val Glu Glu 
    50                  55                  60                  


Leu Leu Glu Lys Leu Val Arg Leu Val Ile Glu Val Leu Glu Glu Leu 
65                  70                  75                  80  


Glu Arg His Pro His Lys Glu Asn Asn Glu His Ala Ala Met Arg Phe 
                85                  90                  95      


Val Leu Ala Val Tyr Leu Ile Glu Glu Asn Leu Arg Glu 
            100                 105                 


<210>  109
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  109

Glu Trp Glu Glu Val Leu Lys Asp Leu Glu Glu Ala Leu Glu Arg Leu 
1               5                   10                  15      


His Asp Glu Glu Ile Arg Arg Leu Leu Glu Arg Val Val Glu Leu Leu 
            20                  25                  30          


Arg Glu Asp Thr Asp His Ser Ile Val Tyr Leu Ile Glu Ala Leu Ile 
        35                  40                  45              


Phe Val Ile Glu Ala Val Glu Arg Thr Gly Asp Glu Arg Ile His Arg 
    50                  55                  60                  


Leu Leu Glu Glu Leu Val Arg Arg Ile Ile Lys Val Ile Glu Glu Leu 
65                  70                  75                  80  


His Arg His Pro His Lys Glu Asn Asn Glu His Ala Ala Met Arg Phe 
                85                  90                  95      


Val Leu Ala Val Tyr Leu Ile Glu Glu Asn Leu Arg Glu 
            100                 105                 


<210>  110
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  110

Glu Glu Arg Glu Leu Ala Arg Glu Leu Glu Arg Leu Ala Arg Glu Arg 
1               5                   10                  15      


Arg Asp His Ser Ile Glu Tyr Ala Arg Glu Ala Ala Glu Phe Ala Arg 
            20                  25                  30          


Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg 
        35                  40                  45              


Glu Leu Val Arg Leu Ala Arg Asn Gly Ser Asp Glu His Ala Leu Met 
    50                  55                  60                  


Arg Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg Glu 
65                  70                  75                  


<210>  111
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  111

Glu Glu Arg Glu Leu Ala Arg Glu Leu Glu Arg Leu Ala Lys Glu Ala 
1               5                   10                  15      


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Ser Asp Val Asn Glu Ala 
            20                  25                  30          


Leu His Ser Ile Glu Tyr Ala Arg Glu Ala Ala Glu Phe Ala Arg Glu 
        35                  40                  45              


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
    50                  55                  60                  


Leu Val Arg Leu Ala Arg Asn Gly Ser Asp Glu His Ala Leu Met Arg 
65                  70                  75                  80  


Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg Glu 
                85                  90                  


<210>  112
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  112

Asp Glu Glu Glu Ile Arg Lys Arg Ile Glu Glu Gln Trp Arg Arg Asp 
1               5                   10                  15      


Thr Asp His Ser Trp Glu Tyr Leu Arg Glu Val Ala Glu Phe Ala Arg 
            20                  25                  30          


Glu Ile Leu Glu Arg Thr Gly Asp Glu Arg Ile Lys Glu Leu Val Leu 
        35                  40                  45              


Arg Ile Leu Glu Leu Ile Glu Asn Gly Thr Asp Asp His Ala Ile Met 
    50                  55                  60                  


Arg Leu Val Leu Ala Leu Tyr Leu Ile Glu Glu Asn Leu Arg Glu 
65                  70                  75                  


<210>  113
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  113

Asp Glu Glu Glu Leu Arg Glu Glu Val Glu His Leu Trp Arg Glu Asp 
1               5                   10                  15      


Thr Asp His Ser Trp Glu Tyr Leu Arg Glu Ala Leu Glu Phe Leu Arg 
            20                  25                  30          


Glu Ile Val Glu Arg Thr Gly Asp Glu Arg Leu Arg Glu Leu Leu Lys 
        35                  40                  45              


Lys Ala Leu Glu Leu Val Arg His Gly Thr Asp Gly His Ala Ile Met 
    50                  55                  60                  


Arg Leu Val Leu Ala Ala Tyr Leu Leu Glu Glu Asn Leu Arg Glu 
65                  70                  75                  


<210>  114
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  114

Tyr Ala Lys Glu Ala Ala Glu Phe Ala Arg Glu Ala Ala Glu Arg Thr 
1               5                   10                  15      


Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Glu Arg Leu Ala 
            20                  25                  30          


Arg Arg Gly Ser Ser Glu His Ala Leu Met Arg Ile Val Leu Ala Ile 
        35                  40                  45              


Tyr Leu Ala Glu Glu Asn Leu Arg Glu 
    50                  55          


<210>  115
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  115

Tyr Ala Lys Glu Val Ala Glu Phe Val Arg Glu Val Trp Glu Arg Thr 
1               5                   10                  15      


Gly Asp Glu Arg Val Glu Glu Leu Leu Lys Lys Leu Glu Glu Leu Arg 
            20                  25                  30          


Arg Asn Gly Ser Asp Glu His Ala Leu Met Arg Leu Val Leu Ala Val 
        35                  40                  45              


Tyr Leu Ile Glu Glu Asn Leu Arg Glu 
    50                  55          


<210>  116
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  116

Tyr Trp Lys Glu Val Ala Glu Phe Leu Arg Glu Val Leu Glu Arg Thr 
1               5                   10                  15      


Gly Asp Glu Glu Val Lys Lys Leu Leu Glu Glu Phe Glu Glu Leu Arg 
            20                  25                  30          


Arg Arg Gly Ser Asp Glu His Ala Leu Met Arg Leu Val Leu Ala Val 
        35                  40                  45              


Tyr Leu Ile Glu Glu Asn Leu Arg Glu 
    50                  55          


<210>  117
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  117

Asp Glu Glu Glu Leu Glu Arg Lys Ile Glu Glu Gln Val Arg Lys Leu 
1               5                   10                  15      


Arg Glu Glu Val Glu Arg Arg Ser His Asp Ser Asp Leu Asn Glu Ala 
            20                  25                  30          


Leu His Ser Met Glu Tyr Leu Arg Glu Ile Ala Glu Phe Ala Arg Glu 
        35                  40                  45              


Ile Val Glu Arg Thr Gly Asp Glu Glu Leu Arg Lys Leu Leu Lys Glu 
    50                  55                  60                  


Ile Leu Arg Leu Ile His Glu Asn Pro Glu Asp Val Gly His Ala Ile 
65                  70                  75                  80  


Met Arg Leu Ile Leu Ala Leu Tyr Leu Leu Glu Glu Asn Leu Arg Glu 
                85                  90                  95      


<210>  118
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  118

Asp Asp Asn Glu Ala Glu Lys Leu Ile Arg Glu Ala Glu Glu Ala Ala 
1               5                   10                  15      


Lys Asp Ala Glu Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg 
            20                  25                  30          


Glu Leu Ala Arg Glu Leu Val Arg Leu Ala Lys Glu Ala Ala Glu Glu 
        35                  40                  45              


Val Gln Arg Asn Pro Ser Ser Ser Asp Val Asn Glu Ala Leu His Ser 
    50                  55                  60                  


Ile Val Tyr Ala Ile Glu Ala Ala Ile Phe Ala Leu Glu Ala Ala Glu 
65                  70                  75                  80  


Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg 
                85                  90                  95      


Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Arg 
            100                 105                 110         


Asn Val Glu His Ala Leu Met Arg Ile Val Leu Ala Ile Tyr Leu Ala 
        115                 120                 125             


Glu Glu Asn Leu Arg Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg 
    130                 135                 140                 


Glu Lys Ala Arg Glu Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu 
145                 150                 155                 160 


Val Gln Arg Asp 
                


<210>  119
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  119

Glu Glu Arg Glu Leu Ala Arg Glu Leu Glu Arg Leu Ala Lys Glu Ala 
1               5                   10                  15      


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Ser Asp Val Asn Glu Ala 
            20                  25                  30          


Leu His Ser Ile Glu Tyr Ala Arg Glu Ala Ala Glu Phe Ala Arg Glu 
        35                  40                  45              


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
    50                  55                  60                  


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
65                  70                  75                  80  


Ser Ser Arg Asn Val Glu His Ala Leu Met Arg Ile Val Leu Ala Ile 
                85                  90                  95      


Tyr Leu Ala Glu Glu Asn Leu Arg Glu Ala Glu Glu Ser Gly Asp Pro 
            100                 105                 110         


Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg Glu Ala Val Glu Arg 
        115                 120                 125             


Ala Glu Glu Val Gln Arg Asp 
    130                 135 


<210>  120
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  120

Asp Glu Asn Glu Ala Glu His Ser Arg Arg Tyr Ala Lys Glu Ala Ala 
1               5                   10                  15      


Glu Phe Ala Arg Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg 
            20                  25                  30          


Glu Leu Ala Arg Glu Leu Glu Arg Leu Ala Arg Glu Ala Ala Glu Glu 
        35                  40                  45              


Val Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala Leu Met Arg 
    50                  55                  60                  


Ile Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg Glu Ala Glu 
65                  70                  75                  80  


Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg 
                85                  90                  95      


Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp 
            100                 105             


<210>  121
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  121

Asp Glu Asn Glu Leu Glu His Ile Arg Arg Tyr Leu Lys Glu Ile Leu 
1               5                   10                  15      


Glu Phe Val Arg Glu Val Val Glu Arg Thr Gly Asp Glu His Ile Arg 
            20                  25                  30          


Arg Leu Leu Glu Glu Leu Glu Arg Leu Val Lys Lys Val Ile Glu Glu 
        35                  40                  45              


Leu Lys Arg Arg Pro Asp Leu His His Asn Glu His Ala Phe Met Arg 
    50                  55                  60                  


Leu Val Leu Ala Val Tyr Leu Ala Glu Glu Asn Leu Arg Glu Ala Glu 
65                  70                  75                  80  


Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg 
                85                  90                  95      


Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp 
            100                 105             


<210>  122
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  122

Asp Glu Asn Glu Leu Glu His Ile Arg Arg Tyr Leu Lys Glu Val Leu 
1               5                   10                  15      


Glu Phe Val Arg Glu Ile Leu Glu Arg Thr Gly Asp Glu Glu Val Lys 
            20                  25                  30          


Lys Leu Ile Glu Glu Leu Glu Arg Leu Val Lys Lys Ile Glu Glu Glu 
        35                  40                  45              


Leu Lys Arg Asp Pro Arg Arg His His Asn Glu His Ala Val Met Arg 
    50                  55                  60                  


Leu Val Leu Ala Val Tyr Leu Leu Glu Glu Asn Leu Arg Glu Ala Glu 
65                  70                  75                  80  


Glu Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg 
                85                  90                  95      


Glu Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp 
            100                 105             


<210>  123
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  123

Asp Glu Glu Glu Leu His Lys Arg Val Glu Glu Leu Trp Lys Glu Leu 
1               5                   10                  15      


His Glu Leu Val Arg Arg His Ser His Asp Ser Asp Leu Asn Glu Leu 
            20                  25                  30          


Leu His Ile Ile Glu Tyr Leu Arg Glu Val Leu Glu Phe Val Arg Glu 
        35                  40                  45              


Val Leu Glu Arg Thr Gly Asp Glu His Ile Lys Arg Leu Leu His Glu 
    50                  55                  60                  


Leu Val Lys Arg Ile Val Glu Thr Ile Glu Glu Leu Lys Arg Asn Ser 
65                  70                  75                  80  


His His Ser Asn Asn Glu His Ala Val Met Arg Ile Val Leu Ala Val 
                85                  90                  95      


Tyr Leu Ala Glu Glu Asn Leu Arg Glu Ala Glu Glu Ser Gly Asp Pro 
            100                 105                 110         


Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg Glu Ala Val Glu Arg 
        115                 120                 125             


Ala Glu Glu Val Gln Arg Asp 
    130                 135 


<210>  124
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  124

Asp Glu Glu Glu Leu Glu Arg Arg Leu Glu Glu Leu Trp Arg Arg Ile 
1               5                   10                  15      


Lys Glu Arg Val Glu Arg His Ser His Asp Ser Asp Leu Asn Glu Leu 
            20                  25                  30          


Leu His Ile Ile Glu Tyr Leu Arg Glu Val Val Glu Phe Val Arg Glu 
        35                  40                  45              


Val Val Glu Arg Thr Gly Asp Glu His Ile Lys Arg Leu Leu Leu Glu 
    50                  55                  60                  


Leu Ile Arg Glu Ile Val Glu Val Ile Glu Lys Leu Glu Arg Asn Leu 
65                  70                  75                  80  


His Asp Ser Asn Asn Glu His Ala Val Met Arg Ile Val Leu Ala Val 
                85                  90                  95      


Tyr Leu Ala Glu Glu Asn Leu Arg Glu Ala Glu Glu Ser Gly Asp Pro 
            100                 105                 110         


Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg Glu Ala Val Glu Arg 
        115                 120                 125             


Ala Glu Glu Val Gln Arg Asp 
    130                 135 


<210>  125
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  125

Asp Asp Asn Glu Ala Glu Lys Leu Ile Arg Glu Ala Glu Glu Val Leu 
1               5                   10                  15      


Lys Asp Ile Glu Glu Ile Leu Glu Arg Leu His Asp Glu Glu Ile Ile 
            20                  25                  30          


Arg Leu Val Glu Glu Val Gln Lys Ile Leu Lys Glu Leu Leu Glu Arg 
        35                  40                  45              


Val His Lys His Pro His Asp Ser Asp Leu Asn Glu Leu Leu His Ile 
    50                  55                  60                  


Ile Phe Tyr Met Met Glu Val Leu Ile Phe Val Leu Glu Val Leu Glu 
65                  70                  75                  80  


Arg Thr Gly Asp Glu Glu Ile Arg Lys Leu Val Trp His Ile Val Arg 
                85                  90                  95      


Ile Ile Leu Glu Ile Leu Glu Glu Leu Arg Arg Asn Pro Lys His Ser 
            100                 105                 110         


Asn Asn Glu His Ala Leu Met Arg Leu Leu Leu Ala Ile Tyr Leu Leu 
        115                 120                 125             


Glu Glu Asn Leu Arg Glu Ala Glu Glu Ser Gly Asp Pro Glu Lys Arg 
    130                 135                 140                 


Glu Lys Ala Arg Glu Arg Val Arg Glu Ala Val Glu Arg Ala Glu Glu 
145                 150                 155                 160 


Val Gln Arg Asp 
                


<210>  126
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  126

Glu Ala Glu Glu Ala Ala Lys Asp Ala Glu Glu Ala Ala Glu Arg Leu 
1               5                   10                  15      


His Asp Pro Glu Val Arg Glu Leu Ala Arg Glu Leu Val Arg Leu Ala 
            20                  25                  30          


Lys Glu Val Asp Asp His Ser Ile Val Tyr Ala Ile Glu Ala Ala Ile 
        35                  40                  45              


Phe Ala Leu Glu Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu 
    50                  55                  60                  


Leu Ala Arg Glu Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val 
65                  70                  75                  80  


Gln Arg Asn Pro Ser Ser Arg Asn Val Glu His Ala Leu Met Arg Ile 
                85                  90                  95      


Val Leu Ala Ile Tyr Leu Ala Glu Glu Asn Leu Arg Glu Ala Glu Glu 
            100                 105                 110         


Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg Glu 
        115                 120                 125             


Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp 
    130                 135                 


<210>  127
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  127

Glu Phe Glu Glu Val Leu Lys Asp Leu Glu Glu Val Val Glu Arg Leu 
1               5                   10                  15      


His Asn Glu Glu Ile Arg Arg Leu Leu Glu Arg Leu Ile Glu Leu Leu 
            20                  25                  30          


Arg Arg Val Arg Asp His Ser Phe Ile Tyr Leu Val Glu Ala Val Ile 
        35                  40                  45              


Phe Val Leu Glu Val Leu Glu Arg Thr Gly Asp His Arg Val Glu Glu 
    50                  55                  60                  


Leu Leu Glu Lys Leu Val Arg Leu Val Ile Glu Val Leu Glu Glu Leu 
65                  70                  75                  80  


Glu Arg His Pro His Lys Glu Asn Asn Glu His Ala Ala Met Arg Phe 
                85                  90                  95      


Val Leu Ala Val Tyr Leu Ile Glu Glu Asn Leu Arg Glu Ala Glu Glu 
            100                 105                 110         


Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg Glu 
        115                 120                 125             


Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp 
    130                 135                 


<210>  128
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  128

Glu Trp Glu Glu Val Leu Lys Asp Leu Glu Glu Ala Leu Glu Arg Leu 
1               5                   10                  15      


His Asp Glu Glu Ile Arg Arg Leu Leu Glu Arg Val Val Glu Leu Leu 
            20                  25                  30          


Arg Glu Asp Thr Asp His Ser Ile Val Tyr Leu Ile Glu Ala Leu Ile 
        35                  40                  45              


Phe Val Ile Glu Ala Val Glu Arg Thr Gly Asp Glu Arg Ile His Arg 
    50                  55                  60                  


Leu Leu Glu Glu Leu Val Arg Arg Ile Ile Lys Val Ile Glu Glu Leu 
65                  70                  75                  80  


His Arg His Pro His Lys Glu Asn Asn Glu His Ala Ala Met Arg Phe 
                85                  90                  95      


Val Leu Ala Val Tyr Leu Ile Glu Glu Asn Leu Arg Glu Ala Glu Glu 
            100                 105                 110         


Ser Gly Asp Pro Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg Glu 
        115                 120                 125             


Ala Val Glu Arg Ala Glu Glu Val Gln Arg Asp 
    130                 135                 


<210>  129
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  129

Thr Ser Ser Asp Glu Glu Glu Ala Arg Glu Leu Ile Glu Glu Ala Lys 
1               5                   10                  15      


Glu Ala Ala Glu Asp Ala Gln Glu Ala Ala Glu Arg Thr Gly Asp Pro 
            20                  25                  30          


Glu Val Arg Glu Leu Ala Arg Glu Leu Lys Arg Leu Ala Gln Glu Ala 
        35                  40                  45              


Ala Glu Glu Val Gln Arg Asn Pro Ser Ser Ser Asp Val Asn Glu Ala 
    50                  55                  60                  


Leu His Ser Ile Val Tyr Ala Ile Glu Ala Ala Ile Phe Ala Leu Glu 
65                  70                  75                  80  


Ala Ala Glu Arg Thr Gly Asp Pro Glu Val Arg Glu Leu Ala Arg Glu 
                85                  90                  95      


Leu Val Arg Leu Ala Val Glu Ala Ala Glu Glu Val Gln Arg Asn Pro 
            100                 105                 110         


Ser Ser Arg Asn Val Glu His Ala Leu Met Arg Ile Val Leu Ala Ile 
        115                 120                 125             


Tyr Leu Ala Glu Glu Asn Leu Arg Glu Ala Glu Glu Ser Gly Asp Pro 
    130                 135                 140                 


Glu Lys Arg Glu Lys Ala Arg Glu Arg Val Arg Glu Ala Val Glu Arg 
145                 150                 155                 160 


Ala Glu Glu Val Gln Arg Asp Pro Ser Gly Trp Leu Asn His 
                165                 170                 


<210>  130
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  130

Asp Ile Glu Lys Leu Cys Lys Lys Ala Glu Glu Glu Ala Lys Glu Ala 
1               5                   10                  15      


Gln Glu Lys Ala Asp Glu Leu Arg Gln Arg His Pro Asp Ser Gln Ala 
            20                  25                  30          


Ala Glu Asp Ala Glu Asp Leu Ala Asn Leu Ala Val Ala Ala Val Leu 
        35                  40                  45              


Thr Ala Cys Leu Leu Ala Gln Glu His Pro Asn Ala Asp Ile Ala Lys 
    50                  55                  60                  


Leu Cys Ile Lys Ala Ala Ser Glu Ala Ala Glu Ala Ala Ser Lys Ala 
65                  70                  75                  80  


Ala Glu Leu Ala Gln Arg His Pro Asp Ser Gln Ala Ala Arg Asp Ala 
                85                  90                  95      


Ile Lys Leu Ala Ser Gln Ala Ala Arg Ala Val Ile Leu Ala Ile Met 
            100                 105                 110         


Leu Ala Ala Glu Asn Pro Asn Ala Asp Ile Ala Lys Lys Cys Ile Lys 
        115                 120                 125             


Ala Ala Ser Glu Ala Ala Glu Glu Ala Ser Lys Ala Ala Glu Glu Ala 
    130                 135                 140                 


Gln Arg His Pro Asp Ser Gln Lys Ala Arg Asp Glu Ile Lys Glu Ala 
145                 150                 155                 160 


Ser Gln Lys Ala Glu Glu Val Glu Arg Arg Cys Trp Arg Ala Ala Glu 
                165                 170                 175     


Asn 
    


<210>  131
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  131

Asp Ile Glu Lys Leu Cys Lys Lys Ala Glu Glu Glu Ala Lys Glu Glu 
1               5                   10                  15      


Gly Asn Glu Leu Ala Val Ala Ala Val Leu Thr Ala Cys Leu Leu Ala 
            20                  25                  30          


Gln Glu Trp Pro Asn Ser His Ile Ala Lys Leu Cys Ile Lys Ala Ala 
        35                  40                  45              


Ser Glu Ala Ala Glu Arg Gly Asp Ser Gln Ala Ala Arg Ala Val Ile 
    50                  55                  60                  


Leu Ala Ile Met Leu Ala Ala Glu Asn Pro Asn Asn Glu His Ala Glu 
65                  70                  75                  80  


Glu Cys Ile Arg Leu Ala Met Glu Ala Ala Arg Asp Gly Thr Ser Glu 
                85                  90                  95      


His Ala Glu Arg Val Glu Arg Glu Cys Trp Lys His Met Glu 
            100                 105                 110 


<210>  132
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  132

Asp Ile Glu Lys Leu Cys Lys Lys Ala Glu Glu Glu Ala Lys Glu Val 
1               5                   10                  15      


Gly Asp Asn Leu Ala Val Ala Ala Val Leu Thr Ala Cys Leu Leu Ala 
            20                  25                  30          


Gln Glu His Pro Asn Ala Asp Ile Ala Lys Leu Cys Ile Lys Ala Ala 
        35                  40                  45              


Ser Glu Ala Ala Glu Ser Gly Asp Lys Gln Ala Ala Arg Ala Val Ile 
    50                  55                  60                  


Leu Ala Ile Met Leu Ala Ala Glu Asn Pro Asn Ala Asp Ile Ala Lys 
65                  70                  75                  80  


Leu Cys Ile Lys Ala Ala Ser Glu Ala Ala Glu Gly Ser Lys His Gly 
                85                  90                  95      


Trp Ser Gln Ala Ala Glu Ala Val Glu Arg Ala Ile Trp Leu Ala Ala 
            100                 105                 110         


Glu Asn Pro Asn Ala Asp Ile Ala Lys Lys Cys Ile Lys Ala Ala Ser 
        115                 120                 125             


Glu Ala Ala Arg Glu Gly Asn Ser Gln Lys Ala Glu Glu Val Lys Glu 
    130                 135                 140                 


Arg Cys Lys Ser 
145             


<210>  133
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  133

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala 
            20                  25                  30          


Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val 
        35                  40                  45              


Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr 
    50                  55                  60                  


Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu 
65                  70                  75                  80  


Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys 
                85                  90                  95      


Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser 
            100                 105                 110         


Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly 
        115                 120                 125             


Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe 
    130                 135                 140                 


Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro 
145                 150                 155                 160 


Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met 
                165                 170                 175     


Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys 
            180                 185                 190         


Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys 
        195                 200                 205             


Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys 
    210                 215                 220                 


Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr 
225                 230                 235                 240 


Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr 
                245                 250                 255     


Lys Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
            260                 265                 270         


Val Glu Glu Asn Pro Gly Pro 
        275                 


<210>  134
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  134
tctagagggt atataatggg ggcca                                             25


<210>  135
<211>  97
<212>  DNA
<213>  Homo sapiens

<400>  135
gaattcaggg ctgggcataa aagtcagggc agagccatct attgcttaca tttgcttctg       60

acacaactgt gttcactagc aacctcaaac agacacc                                97


<210>  136
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  136
tcgaggacat tttgacaccc ccataatatt tttccagaat taacagtata aattgcatct       60

cttgttcaag agttccctat cactctcttt aatcactact cacagtaacc tcaactcctg      120


<210>  137
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  137
gaggtaggcg tgtacggtgg gcgcctataa aagcagagct cgtttagtga accgtcagat       60

cgcctgga                                                                68


<210>  138
<211>  125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  138
acgtataagc tttgcttatg taaaccaggg cgcctataaa agagtgctga ttttttgagt       60

aaacttcaat tccacaacac ttttgtctta taccaacttt ccgtaccact tcctaccctc      120

gtaaa                                                                  125


<210>  139
<211>  386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  139
tgaaagaccc cacctgtagg tttggcaagc taggatcaag gttaggaaca gagagacagc       60

agaatatggg ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag      120

aacagttgga acagcagaat atgggccaaa caggatatct gtggtaagca gttcctgccc      180

cggctcaggg ccaagaacag atggtcccca gatgcggtcc cgccctcagc agtttctaga      240

gaaccatcag atgtttccag ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga      300

actaaccaat cagttcgctt ctcgcttctg ttcgcgcgct tctgctcccc gagctcaata      360

aaagagccca caacccctca ctcggc                                           386


<210>  140
<211>  511
<212>  DNA
<213>  Homo sapiens

<400>  140
ggggttgggg ttgcgccttt tccaaggcag ccctgggttt gcgcagggac gcggctgctc       60

tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc      120

cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc      180

tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac      240

ggaagccgca cgtctcacta gtaccctcgc agacggacag cgccagggag caatggcagc      300

gcgccgaccg cgatgggctg tggccaatag cggctgctca gcagggcgcg ccgagagcag      360

cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct      420

gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc acgtcggcag tcggctccct      480

cgttgaccga atcaccgacc tctctcccca g                                     511


<210>  141
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  141

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
            20                  25                  30          


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
        35                  40              


<210>  142
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  142

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
            20                  25                  30          


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        35                  40              


<210>  143
<211>  528
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  143
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catgctgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagat                   528


<210>  144
<211>  533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  144
attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg       60

tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat      120

gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca      180

gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat      240

taccatggtc gaggtgagcc ccacgttctg cttcactctc cccatctccc ccccctcccc      300

acccccaatt ttgtatttat ttatttttta attattttgt gcagcgatgg gggcgggggg      360

gggggggggg cgcgcgccag gcggggcggg gcggggcgag gggcggggcg gggcgaggcg      420

gagaggtgcg gcggcagcca atcagagcgg cgcgctccga aagtttcctt ttatggcgag      480

gcggcggcgg cggcggccct ataaaaagcg aagcgcgcgg cgggcgatcg att             533


<210>  145
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  145
gtaacgccat tttgcaaggc atggaaaaat accaaaccaa gaatagagaa gttcagatca       60

agggcgggta catgaaaata gctaacgttg ggccaaacag gatatctgcg gtgagcagtt      120

tcggccccgg cccggggcca agaacagatg gtcaccgcag tttcggcccc ggcccgaggc      180

caagaacaga tggtccccag atatggccca accctcagca gtttcttaag acccatcaga      240

tgtttccagg ctcccccaag gacctgaaat gaccctgcgc cttatttgaa ttaaccaatc      300

agcctgcttc tcgcttctgt tcgcgcgctt ctgcttcccg agctctataa aagagctcac      360

aacccctcac tcggcgcgcc agtcctccga cagactgagt cgcccggg                   408


<210>  146
<211>  212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  146
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa       60

ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac ag                                    212


<210>  147
<211>  1219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  147
ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg       60

ccacgtcaga cgaagggcgc agcgagcgtc ctgatccttc cgcccggacg ctcaggacag      120

cggcccgctg ctcataagac tcggccttag aaccccagta tcagcagaag gacattttag      180

gacgggactt gggtgactct agggcactgg ttttctttcc agagagcgga acaggcgagg      240

aaaagtagtc ccttctcggc gattctgcgg agggatctcc gtggggcggt gaacgccgat      300

gattatataa ggacgcgccg ggtgtggcac agctagttcc gtcgcagccg ggatttgggt      360

cgcggttctt gtttgtggat cgctgtgatc gtcacttggt gagtagcggg ctgctgggct      420

ggccggggct ttcgtggccg ccgggccgct cggtgggacg gaagcgtgtg gagagaccgc      480

caagggctgt agtctgggtc cgcgagcaag gttgccctga actgggggtt ggggggagcg      540

cagcaaaatg gcggctgttc ccgagtcttg aatggaagac gcttgtgagg cgggctgtga      600

ggtcgttgaa acaaggtggg gggcatggtg ggcggcaaga acccaaggtc ttgaggcctt      660

cgctaatgcg ggaaagctct tattcgggtg agatgggctg gggcaccatc tggggaccct      720

gacgtgaagt ttgtcactga ctggagaact cggtttgtcg tctgttgcgg gggcggcagt      780

tatggcggtg ccgttgggca gtgcacccgt acctttggga gcgcgcgccc tcgtcgtgtc      840

gtgacgtcac ccgttctgtt ggcttataat gcagggtggg gccacctgcc ggtaggtgtg      900

cggtaggctt ttctccgtcg caggacgcag ggttcgggcc tagggtaggc tctcctgaat      960

cgacaggcgc cggacctctg gtgaggggag ggataagtga ggcgtcagtt tctttggtcg     1020

gttttatgta cctatcttct taagtagctg aagctccggt tttgaactat gcgctcgggg     1080

ttggcgagtg tgttttgtga agttttttag gcaccttttg aaatgtaatc atttgggtca     1140

atatgtaatt ttcagtgtta gactagtaaa ttgtccgcta aattctggcc gtttttggct     1200

tttttgttag acatcgatt                                                  1219


