                         SEQUENCE LISTING

<110>  WESTLAKE THERAPEUTICS (HANGZHOU) CO. LIMITED
 
<120>  Modified Red Blood Cells and Uses Thereof for Treating 
       Hyperuricemia and Gout

<130>  PF 211212PCT

<150>  PCT/CN2021/075303
<151>  2021-02-04

<160>  38    

<170>  PatentIn version 3.3

<210>  1
<211>  206
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  1

Met Lys Lys Trp Thr Asn Arg Leu Met Thr Ile Ala Gly Val Val Leu 
1               5                   10                  15      


Ile Leu Val Ala Ala Tyr Leu Phe Ser Lys Pro His Ile Asp Asn Tyr 
            20                  25                  30          


Leu His Asp Lys Asp Lys Asp Glu Lys Ile Glu Gln Tyr Asp Lys Asn 
        35                  40                  45              


Val Lys Glu Gln Ala Ser Lys Asp Lys Lys Gln Gln Ala Lys Pro Gln 
    50                  55                  60                  


Ile Pro Lys Asp Lys Ser Lys Val Ala Gly Tyr Ile Glu Ile Pro Asp 
65                  70                  75                  80  


Ala Asp Ile Lys Glu Pro Val Tyr Pro Gly Pro Ala Thr Pro Glu Gln 
                85                  90                  95      


Leu Asn Arg Gly Val Ser Phe Ala Glu Glu Asn Glu Ser Leu Asp Asp 
            100                 105                 110         


Gln Asn Ile Ser Ile Ala Gly His Thr Phe Ile Asp Arg Pro Asn Tyr 
        115                 120                 125             


Gln Phe Thr Asn Leu Lys Ala Ala Lys Lys Gly Ser Met Val Tyr Phe 
    130                 135                 140                 


Lys Val Gly Asn Glu Thr Arg Lys Tyr Lys Met Thr Ser Ile Arg Asp 
145                 150                 155                 160 


Val Lys Pro Thr Asp Val Gly Val Leu Asp Glu Gln Lys Gly Lys Asp 
                165                 170                 175     


Lys Gln Leu Thr Leu Ile Thr Cys Asp Asp Tyr Asn Glu Lys Thr Gly 
            180                 185                 190         


Val Trp Glu Lys Arg Lys Ile Phe Val Ala Thr Glu Val Lys 
        195                 200                 205     


<210>  2
<211>  618
<212>  DNA
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  2
atgaaaaaat ggacaaatcg attaatgaca atcgctggtg tggtacttat cctagtggca     60

gcatatttgt ttgctaaacc acatatcgat aattatcttc acgataaaga taaagatgaa    120

aagattgaac aatatgataa aaatgtaaaa gaacaggcga gtaaagataa aaagcagcaa    180

gctaaacctc aaattccgaa agataaatcg aaagtggcag gctatattga aattccagat    240

gctgatatta aagaaccagt atatccagga ccagcaacac ctgaacaatt aaatagaggt    300

gtaagctttg cagaagaaaa tgaatcacta gatgatcaaa atatttcaat tgcaggacac    360

actttcattg accgtccgaa ctatcaattt acaaatctta aagcagccaa aaaaggtagt    420

atggtgtact ttaaagttgg taatgaaaca cgtaagtata aaatgacaag tataagagat    480

gttaagccta cagatgtagg agttctagat gaacaaaaag gtaaagataa acaattaaca    540

ttaattactt gtgatgatta caatgaaaag acaggcgttt gggaaaaacg taaaatcttt    600

gtagctacag aagtcaaa                                                  618


<210>  3
<211>  181
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  3

Lys Pro His Ile Asp Asn Tyr Leu His Asp Lys Asp Lys Asp Glu Lys 
1               5                   10                  15      


Ile Glu Gln Tyr Asp Lys Asn Val Lys Glu Gln Ala Ser Lys Asp Lys 
            20                  25                  30          


Lys Gln Gln Ala Lys Pro Gln Ile Pro Lys Asp Lys Ser Lys Val Ala 
        35                  40                  45              


Gly Tyr Ile Glu Ile Pro Asp Ala Asp Ile Lys Glu Pro Val Tyr Pro 
    50                  55                  60                  


Gly Pro Ala Thr Arg Glu Gln Leu Asn Arg Gly Val Ser Phe Ala Glu 
65                  70                  75                  80  


Glu Asn Glu Ser Leu Asp Asp Gln Asn Ile Ser Ile Ala Gly His Thr 
                85                  90                  95      


Phe Ile Gly Arg Pro Asn Tyr Gln Phe Thr Asn Leu Lys Ala Ala Lys 
            100                 105                 110         


Lys Gly Ser Met Val Tyr Phe Lys Val Gly Asn Glu Thr Arg Lys Tyr 
        115                 120                 125             


Lys Met Thr Ser Ile Arg Asn Val Lys Pro Thr Ala Val Gly Val Leu 
    130                 135                 140                 


Asp Glu Gln Lys Gly Lys Asp Lys Gln Leu Thr Leu Ile Thr Cys Asp 
145                 150                 155                 160 


Asp Leu Asn Arg Glu Thr Gly Val Trp Glu Thr Arg Lys Ile Leu Val 
                165                 170                 175     


Ala Thr Glu Val Lys 
            180     


<210>  4
<211>  543
<212>  DNA
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  4
aaaccacata tcgataatta tcttcacgat aaagataaag atgaaaagat tgaacaatat     60

gataaaaatg taaaagaaca ggcgagtaaa gataaaaagc agcaagctaa acctcaaatt    120

ccgaaagata aatcgaaagt ggcaggctat attgaaattc cagatgctga tattaaagaa    180

ccagtatatc caggaccagc aacacgtgaa caattaaata gaggtgtaag ctttgcagaa    240

gaaaatgaat cactagatga tcaaaatatt tcaattgcag gacacacttt cattggccgt    300

ccgaactatc aatttacaaa tcttaaagca gccaaaaaag gtagtatggt gtactttaaa    360

gttggtaatg aaacacgtaa gtataaaatg acaagtataa gaaatgttaa gcctacagct    420

gtaggagttc tagatgaaca aaaaggtaaa gataaacaat taacattaat tacttgtgat    480

gatcttaatc gggagacagg cgtttgggaa acacgtaaaa tcttggtagc tacagaagtc    540

aaa                                                                  543


<210>  5
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  5

Leu Phe Ile Asn Glu Gly Lys 
1               5           


<210>  6
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  6

Asn Thr Trp Asn Leu Gly Asn Asn Ala Lys 
1               5                   10  


<210>  7
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  7

Asp Gly Gln Val Ile Ile Ser Gly Ser Gly Val Thr Ile Glu Ser Lys 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  8

Glu Gly Leu Thr Leu Pro Val Pro Phe Asn Ile Leu Pro Ser Pro Lys 
1               5                   10                  15      


<210>  9
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  9

Ile Pro Ile Ser Gln Gly Lys 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  10

Ile Leu Asn Lys Pro Val Gly Leu Lys 
1               5                   


<210>  11
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  11

Glu Leu Glu Val Pro Val His Thr Gly Pro Asn Ser Gln Lys Thr Ala 
1               5                   10                  15      


Asp Leu Thr Arg 
            20  


<210>  12
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  12

Gly Ser Arg Ser Gln Ile Pro Arg 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  13

Ile Leu Ser Ala Gln Gly Cys Lys 
1               5               


<210>  14
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  14

Asn Leu Ser Pro Gly Phe Asn Phe Arg 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  15

Asn Tyr Met Met Ser Asn Gly Tyr Lys 
1               5                   


<210>  16
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  16

Phe Gln Gly Lys Trp Gly Thr Val Cys Asp Asp Asn Phe Ser Lys 
1               5                   10                  15  


<210>  17
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  17

Leu Phe Gly Gly Lys Lys 
1               5       


<210>  18
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  18

Asp Ile Lys Pro Asp Asn Val Leu Leu Asp Val Asn Gly His Ile Arg 
1               5                   10                  15      


<210>  19
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  19

Gly Ala Leu Lys Gln Asn Lys 
1               5           


<210>  20
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  20

Asn Ser Gln Gly Ser Glu Met Phe Gly Asp Asp Asp Lys Arg Arg 
1               5                   10                  15  


<210>  21
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  21

Lys Glu Asn Ser Phe Glu Met Gln Arg 
1               5                   


<210>  22
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  22

Arg Gln Ala Met Lys Glu Met Ser Ile Asp Gln Ala Arg 
1               5                   10              


<210>  23
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  23

Leu Leu Leu Ser Val Leu Pro Gln His Val Ala Met Glu Met Lys 
1               5                   10                  15  


<210>  24
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  24

Thr Ile Glu Leu Gln Met Lys Lys 
1               5               


<210>  25
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  25

Cys Ser Val Asn Asn Gln Gln Ser Lys 
1               5                   


<210>  26
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  26

Asn Gln Glu Leu Cys Gln Val Ala Val Glu Lys Ser Pro Lys 
1               5                   10                  


<210>  27
<211>  304
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  27

Met Ser Ala Val Lys Ala Ala Arg Tyr Gly Lys Asp Asn Val Arg Val 
1               5                   10                  15      


Tyr Lys Val His Lys Asp Glu Lys Thr Gly Val Gln Thr Val Tyr Glu 
            20                  25                  30          


Met Thr Val Cys Val Leu Leu Glu Gly Glu Ile Glu Thr Ser Tyr Thr 
        35                  40                  45              


Lys Ala Asp Asn Ser Val Ile Val Ala Thr Asp Ser Ile Lys Asn Thr 
    50                  55                  60                  


Ile Tyr Ile Thr Ala Lys Gln Asn Pro Val Thr Pro Pro Glu Leu Phe 
65                  70                  75                  80  


Gly Ser Ile Leu Gly Thr His Phe Ile Glu Lys Tyr Asn His Ile His 
                85                  90                  95      


Ala Ala His Val Asn Ile Val Cys His Arg Trp Thr Arg Met Asp Ile 
            100                 105                 110         


Asp Gly Lys Pro His Pro His Ser Phe Ile Arg Asp Ser Glu Glu Lys 
        115                 120                 125             


Arg Asn Val Gln Val Asp Val Val Glu Gly Lys Gly Ile Asp Ile Lys 
    130                 135                 140                 


Ser Ser Leu Ser Gly Leu Thr Val Leu Lys Ser Thr Asn Ser Gln Phe 
145                 150                 155                 160 


Trp Gly Phe Leu Arg Asp Glu Tyr Thr Thr Leu Lys Glu Thr Trp Asp 
                165                 170                 175     


Arg Ile Leu Ser Thr Asp Val Asp Ala Thr Trp Gln Trp Lys Asn Phe 
            180                 185                 190         


Ser Gly Leu Gln Glu Val Arg Ser His Val Pro Lys Phe Asp Ala Thr 
        195                 200                 205             


Trp Ala Thr Ala Arg Glu Val Thr Leu Lys Thr Phe Ala Glu Asp Asn 
    210                 215                 220                 


Ser Ala Ser Val Gln Ala Thr Met Tyr Lys Met Ala Glu Gln Ile Leu 
225                 230                 235                 240 


Ala Arg Gln Gln Leu Ile Glu Thr Val Glu Tyr Ser Leu Pro Asn Lys 
                245                 250                 255     


His Tyr Phe Glu Ile Asp Leu Ser Trp His Lys Gly Leu Gln Asn Thr 
            260                 265                 270         


Gly Lys Asn Ala Glu Val Phe Ala Pro Gln Ser Asp Pro Asn Gly Leu 
        275                 280                 285             


Ile Lys Cys Thr Val Gly Arg Ser Ser Leu Lys Ser Lys Leu Ala Ala 
    290                 295                 300                 


<210>  28
<211>  274
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  28

Met Ala Ser Asp Val Gly Gly Gly Arg Val Thr Met Ala Met Val Ser 
1               5                   10                  15      


Met Trp Cys Thr Ser Met Asn Ser Ala Ala Val Ser His Arg Cys Trp 
            20                  25                  30          


Ala Asp Asn Ser Thr Ala Ala Ser Gly Ser Ser Ala Ala Ser Gly Asn 
        35                  40                  45              


Arg His Cys Arg Arg Arg Trp Asp Asn Ala Thr Ala Thr Ser Trp Ser 
    50                  55                  60                  


Ala Asp Thr Cys Val Asp Gly Trp Val Tyr Asp Arg Ser Thr Ser Thr 
65                  70                  75                  80  


Val Ala Lys Trp Asn Val Cys Asp Ser His Ala Lys Met Ala Ser Tyr 
                85                  90                  95      


Ala Gly Val Gly Ala Ala Ala Cys Gly Ala Ser Asp Arg Trp Ala Ser 
            100                 105                 110         


Ala Arg Trp Thr Thr Gly Arg Asp Trp Gly Trp Arg Val Ala Ala Asn 
        115                 120                 125             


Gly Lys Gly Ala Val Asp Thr Thr Val Ser Ala Met Arg Ser Met Gly 
    130                 135                 140                 


Ala Ser Gly Thr Arg Met Gly Arg Arg Thr Cys Ser Thr Cys Trp Ala 
145                 150                 155                 160 


Gly Thr Gly Ala Asp Ala Gly Ser Asn Met Gly Val Val Asp Ala Lys 
                165                 170                 175     


Met Gly Ala Ser His Gly Arg Arg Thr Ala Ala Ser Ala Gly Cys Ala 
            180                 185                 190         


Asn Thr Val His Met Gly Ala Arg Ser Ala Ala Val Gly Gly Gly Val 
        195                 200                 205             


Gly Ala Ala Thr Tyr Thr Tyr Ser Ser Thr Val Arg Met Thr Ala Val 
    210                 215                 220                 


Gly Gly Met Ala Ala Arg Gly Gly Ala Gly Val Arg Gly Val His Gly 
225                 230                 235                 240 


Trp Val Tyr Gly Thr Val Val Ser Gly Ala Ala Thr Ser Asp Thr Asp 
                245                 250                 255     


Val Asn Ala Val Lys Lys Ala Thr His Gly Thr Gly Asn Ser Val Lys 
            260                 265                 270         


Ser Thr 
        


<210>  29
<211>  305
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  29

Met Ser Ala Val Lys Ala Ala Arg Tyr Gly Lys Asp Asn Val Arg Val 
1               5                   10                  15      


Tyr Lys Val His Lys Asp Glu Lys Thr Gly Val Gln Thr Val Tyr Glu 
            20                  25                  30          


Met Thr Val Cys Val Leu Leu Glu Gly Glu Ile Glu Thr Ser Tyr Thr 
        35                  40                  45              


Lys Ala Asp Asn Ser Val Ile Val Ala Thr Asp Ser Ile Lys Asn Thr 
    50                  55                  60                  


Ile Tyr Ile Thr Ala Lys Gln Asn Pro Val Thr Pro Pro Glu Leu Phe 
65                  70                  75                  80  


Gly Ser Ile Leu Gly Thr His Phe Ile Glu Lys Tyr Asn His Ile His 
                85                  90                  95      


Ala Ala His Val Asn Ile Val Cys His Arg Trp Thr Arg Met Asp Ile 
            100                 105                 110         


Asp Gly Lys Pro His Pro His Ser Phe Ile Arg Asp Ser Glu Glu Lys 
        115                 120                 125             


Arg Asn Val Gln Val Asp Val Val Glu Gly Lys Gly Ile Asp Ile Lys 
    130                 135                 140                 


Ser Ser Leu Ser Gly Leu Thr Val Leu Lys Ser Thr Asn Ser Gln Phe 
145                 150                 155                 160 


Trp Gly Phe Leu Arg Asp Glu Tyr Thr Thr Leu Lys Glu Thr Trp Asp 
                165                 170                 175     


Arg Ile Leu Ser Thr Asp Val Asp Ala Thr Trp Gln Trp Lys Asn Phe 
            180                 185                 190         


Ser Gly Leu Gln Glu Val Arg Ser His Val Pro Lys Phe Asp Ala Thr 
        195                 200                 205             


Trp Ala Thr Ala Arg Glu Val Thr Leu Lys Thr Phe Ala Glu Asp Asn 
    210                 215                 220                 


Ser Ala Ser Val Gln Ala Thr Met Tyr Lys Met Ala Glu Gln Ile Leu 
225                 230                 235                 240 


Ala Arg Gln Gln Leu Ile Glu Thr Val Glu Tyr Ser Leu Pro Asn Lys 
                245                 250                 255     


His Tyr Phe Glu Ile Asp Leu Ser Trp His Lys Gly Leu Gln Asn Thr 
            260                 265                 270         


Gly Lys Asn Ala Glu Val Phe Ala Pro Gln Ser Asp Pro Asn Gly Leu 
        275                 280                 285             


Ile Lys Cys Thr Val Gly Arg Ser Ser Leu Lys Ser Lys Leu Ala Ala 
    290                 295                 300                 


Cys 
305 


<210>  30
<211>  936
<212>  DNA
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  30
atgtcagcag taaaggcagc aagatacggt aaagataatg tcagagtcta caaggttcac     60

aaggacgaaa aaactggtgt tcaaacagtt tacgaaatga ctgtttgtgt tttgttggaa    120

ggtgaaatcg aaacttctta cacaaaggct gataactcag ttattgttgc aacagattct    180

attaaaaata ctatctatat cacagctaag caaaacccag ttactccacc agaattgttc    240

ggttcaatct tgggtacaca tttcatcgaa aagtacaacc atatccatgc tgcacatgtt    300

aacatcgttt gtcatagatg gactagaatg gatattgatg gtaaaccaca tccacattct    360

tttattagag attcagaaga aaagagaaat gttcaagttg atgttgttga gggtaaaggt    420

atcgatatca agtcttcatt gtcaggttta actgttttga agtctacaaa ttcacaattt    480

tggggtttct tgagagatga atacactaca ttgaaggaaa catgggatag aattttatct    540

actgatgttg atgctacatg gcaatggaag aacttctcag gtttgcaaga agttagatct    600

catgttccaa aatttgatgc tacttgggct acagcaagag aagttacttt gaagacattc    660

gcagaagata actctgcttc agttcaagca actatgtaca agatggctga acaaatcttg    720

gcaagacaac aattgatcga aacagttgaa tattcattac caaataagca ttacttcgaa    780

atcgatttgt cttggcataa gggtttgcaa aacactggta aaaatgctga agttttcgca    840

ccacaatctg atccaaatgg tttgattaaa tgcacagtcg gtagatcctc tttgaagtcc    900

aagttagcag cacaccatca tcatcaccat tgctga                              936


<210>  31
<211>  311
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  31

Met Ser Ala Val Lys Ala Ala Arg Tyr Gly Lys Asp Asn Val Arg Val 
1               5                   10                  15      


Tyr Lys Val His Lys Asp Glu Lys Thr Gly Val Gln Thr Val Tyr Glu 
            20                  25                  30          


Met Thr Val Cys Val Leu Leu Glu Gly Glu Ile Glu Thr Ser Tyr Thr 
        35                  40                  45              


Lys Ala Asp Asn Ser Val Ile Val Ala Thr Asp Ser Ile Lys Asn Thr 
    50                  55                  60                  


Ile Tyr Ile Thr Ala Lys Gln Asn Pro Val Thr Pro Pro Glu Leu Phe 
65                  70                  75                  80  


Gly Ser Ile Leu Gly Thr His Phe Ile Glu Lys Tyr Asn His Ile His 
                85                  90                  95      


Ala Ala His Val Asn Ile Val Cys His Arg Trp Thr Arg Met Asp Ile 
            100                 105                 110         


Asp Gly Lys Pro His Pro His Ser Phe Ile Arg Asp Ser Glu Glu Lys 
        115                 120                 125             


Arg Asn Val Gln Val Asp Val Val Glu Gly Lys Gly Ile Asp Ile Lys 
    130                 135                 140                 


Ser Ser Leu Ser Gly Leu Thr Val Leu Lys Ser Thr Asn Ser Gln Phe 
145                 150                 155                 160 


Trp Gly Phe Leu Arg Asp Glu Tyr Thr Thr Leu Lys Glu Thr Trp Asp 
                165                 170                 175     


Arg Ile Leu Ser Thr Asp Val Asp Ala Thr Trp Gln Trp Lys Asn Phe 
            180                 185                 190         


Ser Gly Leu Gln Glu Val Arg Ser His Val Pro Lys Phe Asp Ala Thr 
        195                 200                 205             


Trp Ala Thr Ala Arg Glu Val Thr Leu Lys Thr Phe Ala Glu Asp Asn 
    210                 215                 220                 


Ser Ala Ser Val Gln Ala Thr Met Tyr Lys Met Ala Glu Gln Ile Leu 
225                 230                 235                 240 


Ala Arg Gln Gln Leu Ile Glu Thr Val Glu Tyr Ser Leu Pro Asn Lys 
                245                 250                 255     


His Tyr Phe Glu Ile Asp Leu Ser Trp His Lys Gly Leu Gln Asn Thr 
            260                 265                 270         


Gly Lys Asn Ala Glu Val Phe Ala Pro Gln Ser Asp Pro Asn Gly Leu 
        275                 280                 285             


Ile Lys Cys Thr Val Gly Arg Ser Ser Leu Lys Ser Lys Leu Ala Ala 
    290                 295                 300                 


His His His His His His Cys 
305                 310     


<210>  32
<211>  918
<212>  DNA
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  32
atgtcagcag taaaggcagc aagatacggt aaagataatg tcagagtcta caaggttcac     60

aaggacgaaa aaactggtgt tcaaacagtt tacgaaatga ctgtttgtgt tttgttggaa    120

ggtgaaatcg aaacttctta cacaaaggct gataactcag ttattgttgc aacagattct    180

attaaaaata ctatctatat cacagctaag caaaacccag ttactccacc agaattgttc    240

ggttcaatct tgggtacaca tttcatcgaa aagtacaacc atatccatgc tgcacatgtt    300

aacatcgttt gtcatagatg gactagaatg gatattgatg gtaaaccaca tccacattct    360

tttattagag attcagaaga aaagagaaat gttcaagttg atgttgttga gggtaaaggt    420

atcgatatca agtcttcatt gtcaggttta actgttttga agtctacaaa ttcacaattt    480

tggggtttct tgagagatga atacactaca ttgaaggaaa catgggatag aattttatct    540

actgatgttg atgctacatg gcaatggaag aacttctcag gtttgcaaga agttagatct    600

catgttccaa aatttgatgc tacttgggct acagcaagag aagttacttt gaagacattc    660

gcagaagata actctgcttc agttcaagca actatgtaca agatggctga acaaatcttg    720

gcaagacaac aattgatcga aacagttgaa tattcattac caaataagca ttacttcgaa    780

atcgatttgt cttggcataa gggtttgcaa aacactggta aaaatgctga agttttcgca    840

ccacaatctg atccaaatgg tttgattaaa tgcacagtcg gtagatcctc tttgaagtcc    900

aagttagcag catgctga                                                  918


<210>  33
<211>  311
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  33

Met Ser Ala Val Lys Ala Ala Arg Tyr Gly Lys Asp Asn Val Arg Val 
1               5                   10                  15      


Tyr Lys Val His Lys Asp Glu Lys Thr Gly Val Gln Thr Val Tyr Glu 
            20                  25                  30          


Met Thr Val Cys Val Leu Leu Glu Gly Glu Ile Glu Thr Ser Tyr Thr 
        35                  40                  45              


Lys Ala Asp Asn Ser Val Ile Val Ala Thr Asp Ser Ile Lys Asn Thr 
    50                  55                  60                  


Ile Tyr Ile Thr Ala Lys Gln Asn Pro Val Thr Pro Pro Glu Leu Phe 
65                  70                  75                  80  


Gly Ser Ile Leu Gly Thr His Phe Ile Glu Lys Tyr Asn His Ile His 
                85                  90                  95      


Ala Ala His Val Asn Ile Val Cys His Arg Trp Thr Arg Met Asp Ile 
            100                 105                 110         


Asp Gly Lys Pro His Pro His Ser Phe Ile Arg Asp Ser Glu Glu Lys 
        115                 120                 125             


Arg Asn Val Gln Val Asp Val Val Glu Gly Lys Gly Ile Asp Ile Lys 
    130                 135                 140                 


Ser Ser Leu Ser Gly Leu Thr Val Leu Lys Ser Thr Asn Ser Gln Phe 
145                 150                 155                 160 


Trp Gly Phe Leu Arg Asp Glu Tyr Thr Thr Leu Lys Glu Thr Trp Asp 
                165                 170                 175     


Arg Ile Leu Ser Thr Asp Val Asp Ala Thr Trp Gln Trp Lys Asn Phe 
            180                 185                 190         


Ser Gly Leu Gln Glu Val Arg Ser His Val Pro Lys Phe Asp Ala Thr 
        195                 200                 205             


Trp Ala Thr Ala Arg Glu Val Thr Leu Lys Thr Phe Ala Glu Asp Asn 
    210                 215                 220                 


Ser Ala Ser Val Gln Ala Thr Met Tyr Lys Met Ala Glu Gln Ile Leu 
225                 230                 235                 240 


Ala Arg Gln Gln Leu Ile Glu Thr Val Glu Tyr Ser Leu Pro Asn Lys 
                245                 250                 255     


His Tyr Phe Glu Ile Asp Leu Ser Trp His Lys Gly Leu Gln Asn Thr 
            260                 265                 270         


Gly Lys Asn Ala Glu Val Phe Ala Pro Gln Ser Asp Pro Asn Gly Leu 
        275                 280                 285             


Ile Lys Cys Thr Val Gly Arg Ser Ser Leu Lys Ser Lys Leu Ala Ala 
    290                 295                 300                 


Gly Ser Gly Ser Gly Ser Cys 
305                 310     


<210>  34
<211>  936
<212>  DNA
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  34
atgtcagcag taaaggcagc aagatacggt aaagataatg tcagagtcta caaggttcac     60

aaggacgaaa aaactggtgt tcaaacagtt tacgaaatga ctgtttgtgt tttgttggaa    120

ggtgaaatcg aaacttctta cacaaaggct gataactcag ttattgttgc aacagattct    180

attaaaaata ctatctatat cacagctaag caaaacccag ttactccacc agaattgttc    240

ggttcaatct tgggtacaca tttcatcgaa aagtacaacc atatccatgc tgcacatgtt    300

aacatcgttt gtcatagatg gactagaatg gatattgatg gtaaaccaca tccacattct    360

tttattagag attcagaaga aaagagaaat gttcaagttg atgttgttga gggtaaaggt    420

atcgatatca agtcttcatt gtcaggttta actgttttga agtctacaaa ttcacaattt    480

tggggtttct tgagagatga atacactaca ttgaaggaaa catgggatag aattttatct    540

actgatgttg atgctacatg gcaatggaag aacttctcag gtttgcaaga agttagatct    600

catgttccaa aatttgatgc tacttgggct acagcaagag aagttacttt gaagacattc    660

gcagaagata actctgcttc agttcaagca actatgtaca agatggctga acaaatcttg    720

gcaagacaac aattgatcga aacagttgaa tattcattac caaataagca ttacttcgaa    780

atcgatttgt cttggcataa gggtttgcaa aacactggta aaaatgctga agttttcgca    840

ccacaatctg atccaaatgg tttgattaaa tgcacagtcg gtagatcctc tttgaagtcc    900

aagttagcag caggttctgg ttctggttct tgctga                              936


<210>  35
<211>  254
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  35

Met His His His His His His Met Val Ser Lys Gly Glu Glu Leu Phe 
1               5                   10                  15      


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
            20                  25                  30          


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
        35                  40                  45              


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
    50                  55                  60                  


Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser 
65                  70                  75                  80  


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
                85                  90                  95      


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
            100                 105                 110         


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
        115                 120                 125             


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
    130                 135                 140                 


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
145                 150                 155                 160 


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
                165                 170                 175     


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
            180                 185                 190         


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
        195                 200                 205             


Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
    210                 215                 220                 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
225                 230                 235                 240 


Met Asp Glu Leu Tyr Lys Ala Ala Leu Pro Glu Thr Gly Gly 
                245                 250                 


<210>  36
<211>  765
<212>  DNA
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  36
atgcaccacc accaccacca catggttagt aaaggggaag aattatttac cggcgtggtg     60

ccgattctgg ttgaactgga cggcgacgtg aacggccaca aattcagcgt tagcggcgag    120

ggcgaaggtg acgcgaccta cggcaagctg accctgaaat ttatctgcac caccggcaag    180

ctgccggtgc cgtggccgac cctggttacc accctgacct acggtgttca gtgcttcagc    240

cgttatccgg accacatgaa gcaacacgat ttctttaaaa gcgcgatgcc ggagggctac    300

gtgcaggaac gtaccatctt ctttaaggac gatggtaact ataaaacccg tgcggaagtg    360

aagttcgaag gcgacaccct ggttaaccgt atcgagctga agggtattga ctttaaagaa    420

gatggcaaca ttctgggtca caaactggag tacaactata acagccacaa cgtgtatatc    480

atggcggata agcagaaaaa cggcattaag gttaacttca aaatccgtca caacattgaa    540

gacggtagcg tgcaactggc ggatcactac cagcaaaaca ccccgattgg cgacggtccg    600

gttctgctgc cggataacca ctatctgagc acccaaagcg cgctgagcaa ggacccgaac    660

gagaaacgtg atcacatggt gctgctggaa tttgttaccg cggcgggtat caccctgggt    720

atggacgaac tgtataaggc ggcgctgccg gagaccggcg gttaa                    765


<210>  37
<211>  247
<212>  PRT
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  37

Met His His His His His His Met Val Ser Lys Gly Glu Glu Leu Phe 
1               5                   10                  15      


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
            20                  25                  30          


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
        35                  40                  45              


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
    50                  55                  60                  


Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser 
65                  70                  75                  80  


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
                85                  90                  95      


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
            100                 105                 110         


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
        115                 120                 125             


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
    130                 135                 140                 


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
145                 150                 155                 160 


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
                165                 170                 175     


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
            180                 185                 190         


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
        195                 200                 205             


Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
    210                 215                 220                 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
225                 230                 235                 240 


Met Asp Glu Leu Tyr Lys Cys 
                245         


<210>  38
<211>  744
<212>  DNA
<213>  artificial sequence

<220>
<223>  constructed sequence

<400>  38
atgcaccacc accaccacca catggttagt aaaggggaag aattatttac cggcgtggtg     60

ccgattctgg ttgaactgga cggcgacgtg aacggccaca aattcagcgt tagcggcgag    120

ggcgaaggtg acgcgaccta cggcaagctg accctgaaat ttatctgcac caccggcaag    180

ctgccggtgc cgtggccgac cctggttacc accctgacct acggtgttca gtgcttcagc    240

cgttatccgg accacatgaa gcaacacgat ttctttaaaa gcgcgatgcc ggagggctac    300

gtgcaggaac gtaccatctt ctttaaggac gatggtaact ataaaacccg tgcggaagtg    360

aagttcgaag gcgacaccct ggttaaccgt atcgagctga agggtattga ctttaaagaa    420

gatggcaaca ttctgggtca caaactggag tacaactata acagccacaa cgtgtatatc    480

atggcggata agcagaaaaa cggcattaag gttaacttca aaatccgtca caacattgaa    540

gacggtagcg tgcaactggc ggatcactac cagcaaaaca ccccgattgg cgacggtccg    600

gttctgctgc cggataacca ctatctgagc acccaaagcg cgctgagcaa ggacccgaac    660

gagaaacgtg atcacatggt gctgctggaa tttgttaccg cggcgggtat caccctgggt    720

atggacgaac tgtataagtg ttaa                                           744


