                         SEQUENCE LISTING

<110>  Numab Therapeutics AG
 
<120>  MULTISPECIFIC ANTIBODIES HAVING SPECIFICITY FOR ROR1 AND CD3

<130>  117181P877PC

<150>  EP21154786.4
<151>  2021-02-02

<150>  PCT/EP2021/087618
<151>  2021-12-23

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  1

Gly Phe Asp Leu Ser Ser Tyr Ala Val Ser 
1               5                   10  


<210>  2
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  2

Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  3
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  3

Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr Thr Tyr Phe Asn 
1               5                   10                  15      


Leu 
    


<210>  4
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  4

Arg Ala Ser Glu Asn Ile Tyr Ser Gly Leu Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  5

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  6
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  6

Gln Gly Gly Tyr Tyr Ser Ser Ser Ser Thr Tyr Ile Ala 
1               5                   10              


<210>  7
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  7

Gln Ser Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr Thr Tyr Phe Asn 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  8
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  8

Gln Ser Gln Val Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr Thr Tyr Phe Asn 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  9
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  9

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


<210>  10
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  10

Gln Ser Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr Thr Tyr Phe Asn 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  11
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  11

Gln Ser Gln Val Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr Thr Tyr Phe Asn 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  12
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  12

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


<210>  13
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  13

Gly Leu Ser Leu Ser Arg Asn Ala Met Ser 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  14

Gly Ile Asp Leu Ser Arg Asn Ala Met Ser 
1               5                   10  


<210>  15
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  15

Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  16
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  16

Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe 
1               5                   10      


<210>  17
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  17

Gln Ala Ser Gln Asn Val Trp Asn Asn Asn Tyr Leu Ser 
1               5                   10              


<210>  18
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  18

Thr Ala Ser Thr Leu Ala Ser 
1               5           


<210>  19
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  19

Ala Gly Gly Phe Ser Gly Glu Ile Arg Ala 
1               5                   10  


<210>  20
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  20

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Ser Leu Ser Arg Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Val 
                85                  90                  95      


Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  21
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  21

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Ser Leu Ser Arg Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Val 
                85                  90                  95      


Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  22
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  22

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  23
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  23

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Ser Leu Ser Arg Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Val 
                85                  90                  95      


Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  24
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  24

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Ser Leu Ser Arg Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Val 
                85                  90                  95      


Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  25
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  25

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  26
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  26

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Arg Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Leu Asp Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Val Arg Gly 
                85                  90                  95      


Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  27
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  27

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  28
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  28

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Arg Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Leu Asp Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Val Arg Gly 
                85                  90                  95      


Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  29
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  29

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  30
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  30

Gly Phe Ser Leu Ser Ser Tyr Asp Met Ser 
1               5                   10  


<210>  31
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  31

Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  32
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  32

Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile 
1               5                   10          


<210>  33
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  33

Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu Ala 
1               5                   10              


<210>  34
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  34

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  35
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  35

Leu Gly Ser Tyr Ala Cys Ser Ser Ala Asp Cys Tyr Val 
1               5                   10              


<210>  36
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Trp Ile 
        35                  40                  45              


Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  37
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Trp Ile 
        35                  40                  45              


Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  38
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn 
            20                  25                  30          


Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg 
        35                  40                  45              


Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys 
                85                  90                  95      


Ser Ser Ala Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu Gly 
        


<210>  39
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  39

Gly Phe Ser Leu Ser Ser Asn Ala Met Gly 
1               5                   10  


<210>  40
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  40

Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  41
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  41

Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu 
1               5                   10                  


<210>  42
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  42

Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser 
1               5                   10              


<210>  43
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  43

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  44
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  44

Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala 
1               5                   10      


<210>  45
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  46
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser 
                85                  90                  95      


Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  47
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Tyr Ile 
        35                  40                  45              


Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  48
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser 
                85                  90                  95      


Ser Ser Asp Thr Ala Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  49
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  49

Gly Phe Ser Phe Ser Ser Ser Tyr Trp Ile Cys 
1               5                   10      


<210>  50
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  50

Cys Val Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  51

Arg Pro Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu 
1               5                   10          


<210>  52
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  52

Gln Ala Ser Gln Ile Ile Ser Ser Arg Ser Ala 
1               5                   10      


<210>  53
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  53

Gln Ala Ser Lys Leu Ala Ser 
1               5           


<210>  54
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  54

Gln Cys Thr Tyr Ile Asp Ser Asn Phe Gly Ala 
1               5                   10      


<210>  55
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Cys Val Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Pro Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  56
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  56

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ile Ile Ser Ser Arg 
            20                  25                  30          


Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Ile Asp Ser Asn 
                85                  90                  95      


Phe Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  57
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp 
        35                  40                  45              


Val Gly Cys Val Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Pro Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  58
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  58

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ile Ile Ser Ser Arg 
            20                  25                  30          


Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Ile Asp Ser Asn 
                85                  90                  95      


Phe Gly Ala Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  59
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  59

Gly Phe Ser Leu Ser Ser Tyr Ala Met Asn 
1               5                   10  


<210>  60
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  60

His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  61
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  61

Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu 
1               5                   10              


<210>  62
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  62

Gln Ala Ser Glu Ser Ile Asn Ser Arg Leu Ala 
1               5                   10      


<210>  63
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  63

Asp Ala Ser Asp Leu Thr Ser 
1               5           


<210>  64
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  64

Gln Gly Tyr Gly Gly Ser Ser Thr Thr Thr 
1               5                   10  


<210>  65
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  66
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  67
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  67

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  68
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  69
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  70
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  70

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  71
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Asn 
            20                  25                  30          


Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp Ala Asn 
    50                  55                  60                  


Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  72
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  72

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ile Asp Phe Asn Ser Asn 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Cys Ile Tyr Val Gly Ser His Val Asn Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Ala Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Ser Gly Ser Ser Val Leu Tyr Phe Lys Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  73
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ile Asp Phe Asn Ser Asn 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Cys Ile Tyr Val Gly Ser His Val Asn Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Ala Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Ser Gly Ser Ser Val Leu Tyr Phe Lys Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  74
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  74

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser Phe Ser Asn Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser Ser Lys Asn Gln 
65                  70                  75                  80  


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly Tyr Ala Asn Asn 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  75
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  75

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly Asn Tyr Gly 
                85                  90                  95      


Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105             


<210>  76
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  76

Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
1               5                   10      


<210>  77
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  77

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
1               5                   10      


<210>  78
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  78

Phe Gly Gly Gly Thr Gln Leu Ile Ile Leu Gly 
1               5                   10      


<210>  79
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  79

Phe Gly Glu Gly Thr Glu Leu Thr Val Leu Gly 
1               5                   10      


<210>  80
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  80

Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly 
1               5                   10      


<210>  81
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  81

Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
1               5                   10      


<210>  82
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  82

Phe Gly Gly Gly Thr Gln Leu Thr Ala Leu Gly 
1               5                   10      


<210>  83
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  83

Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
1               5                   10      


<210>  84
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  84

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  85
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  85

Gly Gly Gly Gly Ser 
1               5   


<210>  86
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  86

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  87
<211>  753
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  87

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ile Ile Ser Ser Arg 
            20                  25                  30          


Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Ile Asp Ser Asn 
                85                  90                  95      


Phe Gly Ala Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        115                 120                 125             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
    130                 135                 140                 


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
145                 150                 155                 160 


Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser 
                165                 170                 175     


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            180                 185                 190         


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
        195                 200                 205             


Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                245                 250                 255     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            260                 265                 270         


Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr 
        275                 280                 285             


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile 
    290                 295                 300                 


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
305                 310                 315                 320 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
                325                 330                 335     


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser 
            340                 345                 350         


Ala Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
        355                 360                 365             


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    370                 375                 380                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
385                 390                 395                 400 


Ser Phe Ser Ser Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly 
                405                 410                 415     


Lys Cys Leu Glu Trp Val Gly Cys Val Phe Thr Gly Asp Gly Thr Thr 
            420                 425                 430         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        435                 440                 445             


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    450                 455                 460                 


Thr Ala Thr Tyr Phe Cys Ala Arg Pro Val Ser Val Tyr Tyr Tyr Gly 
465                 470                 475                 480 


Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Gln Leu Thr Gln Ser Pro 
            500                 505                 510         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
        515                 520                 525             


Ala Ser Gln Asn Val Trp Asn Asn Asn Tyr Leu Ser Trp Phe Gln Gln 
    530                 535                 540                 


Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile Val Thr Ala Ser Thr Leu 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                565                 570                 575     


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            580                 585                 590         


Tyr Cys Ala Gly Gly Phe Ser Gly Glu Ile Arg Ala Phe Gly Thr Gly 
        595                 600                 605             


Thr Lys Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Gln Leu Val 
625                 630                 635                 640 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                645                 650                 655     


Cys Ala Val Ser Gly Leu Ser Leu Ser Arg Asn Ala Met Ser Trp Val 
            660                 665                 670         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Ile Ile Leu Thr 
        675                 680                 685             


Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile 
    690                 695                 700                 


Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
705                 710                 715                 720 


Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Val Arg Gly Ile Ala Ser 
                725                 730                 735     


Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            740                 745                 750         


Ser 
    


<210>  88
<211>  755
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser 
                85                  90                  95      


Ser Ser Asp Thr Ala Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        115                 120                 125             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    130                 135                 140                 


Ser Leu Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr 
                165                 170                 175     


Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
            180                 185                 190         


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        195                 200                 205             


Thr Tyr Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn 
    210                 215                 220                 


Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
            260                 265                 270         


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn 
        275                 280                 285             


Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg 
    290                 295                 300                 


Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                325                 330                 335     


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys 
            340                 345                 350         


Ser Ser Ala Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    370                 375                 380                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
385                 390                 395                 400 


Gly Phe Ser Leu Ser Ser Asn Ala Met Gly Trp Val Arg Gln Ala Pro 
                405                 410                 415     


Gly Lys Cys Leu Glu Tyr Ile Gly Ile Ile Ser Val Gly Gly Phe Thr 
            420                 425                 430         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        435                 440                 445             


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    450                 455                 460                 


Thr Ala Thr Tyr Phe Cys Ala Arg Asp Arg His Gly Gly Asp Ser Ser 
465                 470                 475                 480 


Gly Ala Phe Tyr Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Gln Leu Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        515                 520                 525             


Cys Gln Ala Ser Gln Asn Val Trp Asn Asn Asn Tyr Leu Ser Trp Phe 
    530                 535                 540                 


Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile Val Thr Ala Ser 
545                 550                 555                 560 


Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                565                 570                 575     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            580                 585                 590         


Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly Glu Ile Arg Ala Phe Gly 
        595                 600                 605             


Thr Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Gln 
625                 630                 635                 640 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                645                 650                 655     


Leu Ser Cys Ala Val Ser Gly Leu Ser Leu Ser Arg Asn Ala Met Ser 
            660                 665                 670         


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Ile Ile 
        675                 680                 685             


Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe 
    690                 695                 700                 


Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn 
705                 710                 715                 720 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Val Arg Gly Ile 
                725                 730                 735     


Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly Thr Leu Val Thr 
            740                 745                 750         


Val Ser Ser 
        755 


<210>  89
<211>  758
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  89

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        115                 120                 125             


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
    130                 135                 140                 


Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala 
145                 150                 155                 160 


Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp 
                165                 170                 175     


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
            180                 185                 190         


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
        195                 200                 205             


Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly 
    210                 215                 220                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                245                 250                 255     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            260                 265                 270         


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
        275                 280                 285             


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
    290                 295                 300                 


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
                325                 330                 335     


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
            340                 345                 350         


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    370                 375                 380                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
385                 390                 395                 400 


Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys 
                405                 410                 415     


Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala 
            420                 425                 430         


Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        435                 440                 445             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    450                 455                 460                 


Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys 
465                 470                 475                 480 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Asp Val Gln Met Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        515                 520                 525             


Glu Asn Ile Tyr Ser Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    530                 535                 540                 


Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val 
545                 550                 555                 560 


Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                565                 570                 575     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly 
            580                 585                 590         


Gly Tyr Tyr Ser Ser Ser Ser Thr Tyr Ile Ala Phe Gly Thr Gly Thr 
        595                 600                 605             


Lys Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Gln Val Val Glu 
625                 630                 635                 640 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                645                 650                 655     


Ala Val Ser Gly Phe Asp Leu Ser Ser Tyr Ala Val Ser Trp Val Arg 
            660                 665                 670         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg 
        675                 680                 685             


Ala Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
    690                 695                 700                 


Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
705                 710                 715                 720 


Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser 
                725                 730                 735     


Gly Ala Tyr Leu Tyr Thr Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr 
            740                 745                 750         


Leu Val Thr Val Ser Ser 
        755             


<210>  90
<211>  758
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  90

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        115                 120                 125             


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
    130                 135                 140                 


Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala 
145                 150                 155                 160 


Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp 
                165                 170                 175     


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
            180                 185                 190         


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
        195                 200                 205             


Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly 
    210                 215                 220                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                245                 250                 255     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            260                 265                 270         


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
        275                 280                 285             


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
    290                 295                 300                 


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
                325                 330                 335     


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
            340                 345                 350         


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    370                 375                 380                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
385                 390                 395                 400 


Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys 
                405                 410                 415     


Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala 
            420                 425                 430         


Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        435                 440                 445             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    450                 455                 460                 


Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys 
465                 470                 475                 480 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Asp Val Gln Met Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        515                 520                 525             


Glu Asn Ile Tyr Ser Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    530                 535                 540                 


Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val 
545                 550                 555                 560 


Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                565                 570                 575     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly 
            580                 585                 590         


Gly Tyr Tyr Ser Ser Ser Ser Thr Tyr Ile Ala Phe Gly Cys Gly Thr 
        595                 600                 605             


Lys Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Gln Val Val Glu 
625                 630                 635                 640 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                645                 650                 655     


Ala Val Ser Gly Phe Asp Leu Ser Ser Tyr Ala Val Ser Trp Val Arg 
            660                 665                 670         


Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg 
        675                 680                 685             


Ala Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
    690                 695                 700                 


Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
705                 710                 715                 720 


Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser 
                725                 730                 735     


Gly Ala Tyr Leu Tyr Thr Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr 
            740                 745                 750         


Leu Val Thr Val Ser Ser 
        755             


<210>  91
<211>  751
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  91

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        115                 120                 125             


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
    130                 135                 140                 


Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala 
145                 150                 155                 160 


Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp 
                165                 170                 175     


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
            180                 185                 190         


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
        195                 200                 205             


Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly 
    210                 215                 220                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                245                 250                 255     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            260                 265                 270         


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
        275                 280                 285             


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
    290                 295                 300                 


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
                325                 330                 335     


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
            340                 345                 350         


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    370                 375                 380                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
385                 390                 395                 400 


Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys 
                405                 410                 415     


Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala 
            420                 425                 430         


Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        435                 440                 445             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    450                 455                 460                 


Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys 
465                 470                 475                 480 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        515                 520                 525             


Gln Asn Val Trp Asn Asn Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro 
    530                 535                 540                 


Gly Lys Pro Pro Lys Leu Leu Ile Val Thr Ala Ser Thr Leu Ala Ser 
545                 550                 555                 560 


Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Ala Gly Gly Phe Ser Gly Glu Ile Arg Ala Phe Gly Thr Gly Thr Lys 
        595                 600                 605             


Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Gln Leu Val Glu Ser 
625                 630                 635                 640 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                645                 650                 655     


Val Ser Gly Leu Ser Leu Ser Arg Asn Ala Met Ser Trp Val Arg Gln 
            660                 665                 670         


Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly 
        675                 680                 685             


Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys 
    690                 695                 700                 


Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Phe Cys Val Arg Gly Ile Ala Ser Ser Ser 
                725                 730                 735     


Leu Lys Ser Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750     


<210>  92
<211>  751
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  92

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        115                 120                 125             


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
    130                 135                 140                 


Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala 
145                 150                 155                 160 


Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp 
                165                 170                 175     


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
            180                 185                 190         


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
        195                 200                 205             


Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly 
    210                 215                 220                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                245                 250                 255     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            260                 265                 270         


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
        275                 280                 285             


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
    290                 295                 300                 


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
                325                 330                 335     


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
            340                 345                 350         


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    370                 375                 380                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
385                 390                 395                 400 


Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys 
                405                 410                 415     


Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala 
            420                 425                 430         


Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        435                 440                 445             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    450                 455                 460                 


Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys 
465                 470                 475                 480 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        515                 520                 525             


Gln Asn Val Trp Asn Asn Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro 
    530                 535                 540                 


Gly Lys Pro Pro Lys Leu Leu Ile Val Thr Ala Ser Thr Leu Ala Ser 
545                 550                 555                 560 


Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Ala Gly Gly Phe Ser Gly Glu Ile Arg Ala Phe Gly Cys Gly Thr Lys 
        595                 600                 605             


Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Gln Leu Val Glu Ser 
625                 630                 635                 640 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                645                 650                 655     


Val Ser Gly Leu Ser Leu Ser Arg Asn Ala Met Ser Trp Val Arg Gln 
            660                 665                 670         


Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly 
        675                 680                 685             


Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys 
    690                 695                 700                 


Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Val Tyr Phe Cys Val Arg Gly Ile Ala Ser Ser Ser 
                725                 730                 735     


Leu Lys Ser Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750     


<210>  93
<211>  749
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  93

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        115                 120                 125             


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
    130                 135                 140                 


Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala 
145                 150                 155                 160 


Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp 
                165                 170                 175     


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
            180                 185                 190         


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
        195                 200                 205             


Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly 
    210                 215                 220                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                245                 250                 255     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            260                 265                 270         


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
        275                 280                 285             


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
    290                 295                 300                 


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
                325                 330                 335     


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
            340                 345                 350         


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    370                 375                 380                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
385                 390                 395                 400 


Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys 
                405                 410                 415     


Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala 
            420                 425                 430         


Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        435                 440                 445             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    450                 455                 460                 


Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys 
465                 470                 475                 480 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        515                 520                 525             


Gln Asn Val Trp Asn Asn Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro 
    530                 535                 540                 


Gly Lys Pro Pro Lys Leu Leu Ile Val Thr Ala Ser Thr Leu Ala Ser 
545                 550                 555                 560 


Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Ala Gly Gly Phe Ser Gly Glu Ile Arg Ala Phe Gly Cys Gly Thr Lys 
        595                 600                 605             


Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Gln Leu Val Glu Ser 
625                 630                 635                 640 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                645                 650                 655     


Val Ser Gly Ile Asp Leu Ser Arg Asn Ala Met Ser Trp Val Arg Gln 
            660                 665                 670         


Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly 
        675                 680                 685             


Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys 
    690                 695                 700                 


Thr Ser Thr Thr Leu Asp Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
705                 710                 715                 720 


Thr Ala Val Tyr Phe Cys Val Arg Gly Ile Ala Ser Ser Ser Leu Lys 
                725                 730                 735     


Ser Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 


<210>  94
<211>  749
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  94

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        115                 120                 125             


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
    130                 135                 140                 


Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala 
145                 150                 155                 160 


Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp 
                165                 170                 175     


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
            180                 185                 190         


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
        195                 200                 205             


Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly 
    210                 215                 220                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                245                 250                 255     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            260                 265                 270         


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
        275                 280                 285             


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
    290                 295                 300                 


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
                325                 330                 335     


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
            340                 345                 350         


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    370                 375                 380                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
385                 390                 395                 400 


Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys 
                405                 410                 415     


Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala 
            420                 425                 430         


Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        435                 440                 445             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    450                 455                 460                 


Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys 
465                 470                 475                 480 


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        515                 520                 525             


Gln Asn Val Trp Asn Asn Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro 
    530                 535                 540                 


Gly Lys Pro Pro Lys Leu Leu Ile Val Thr Ala Ser Thr Leu Ala Ser 
545                 550                 555                 560 


Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Ala Gly Gly Phe Ser Gly Glu Ile Arg Ala Phe Gly Thr Gly Thr Lys 
        595                 600                 605             


Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Gln Leu Val Glu Ser 
625                 630                 635                 640 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                645                 650                 655     


Val Ser Gly Ile Asp Leu Ser Arg Asn Ala Met Ser Trp Val Arg Gln 
            660                 665                 670         


Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly 
        675                 680                 685             


Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys 
    690                 695                 700                 


Thr Ser Thr Thr Leu Asp Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
705                 710                 715                 720 


Thr Ala Val Tyr Phe Cys Val Arg Gly Ile Ala Ser Ser Ser Leu Lys 
                725                 730                 735     


Ser Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 


<210>  95
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  95

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Gln Val Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp 
145                 150                 155                 160 


Leu Ser Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr 
225                 230                 235                 240 


Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Glu Leu Thr Gln 
            260                 265                 270         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        275                 280                 285             


Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg Leu Ala Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu 
305                 310                 315                 320 


Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                325                 330                 335     


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr Thr Thr Phe Gly Cys Gly 
        355                 360                 365             


Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
                405                 410                 415     


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
            420                 425                 430         


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        435                 440                 445             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    450                 455                 460                 


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
465                 470                 475                 480 


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                485                 490                 495 


<210>  96
<211>  518
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  96

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Gln Val Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp 
145                 150                 155                 160 


Leu Ser Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr 
225                 230                 235                 240 


Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
            260                 265                 270         


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        275                 280                 285             


Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asp Met Ser Trp Val Arg 
    290                 295                 300                 


Gln Ala Pro Gly Lys Gly Leu Ala Trp Ile Gly Ala Ser Tyr Ala Ser 
305                 310                 315                 320 


Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly Trp Thr Gly 
        355                 360                 365             


Thr Ser His Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu Val 
385                 390                 395                 400 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                405                 410                 415     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala Met 
            420                 425                 430         


Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly His 
        435                 440                 445             


Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly 
                485                 490                 495     


Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln Gly Thr 
            500                 505                 510         


Leu Val Thr Val Ser Ser 
        515             


<210>  97
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  97

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Gln Val Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp 
145                 150                 155                 160 


Leu Ser Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Cys 
                165                 170                 175     


Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr 
225                 230                 235                 240 


Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Glu Leu Thr Gln 
            260                 265                 270         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        275                 280                 285             


Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg Leu Ala Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu 
305                 310                 315                 320 


Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                325                 330                 335     


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr Thr Thr Phe Gly Cys Gly 
        355                 360                 365             


Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
                405                 410                 415     


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
            420                 425                 430         


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        435                 440                 445             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    450                 455                 460                 


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
465                 470                 475                 480 


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                485                 490                 495 


<210>  98
<211>  518
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  98

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Gln Val Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp 
145                 150                 155                 160 


Leu Ser Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Cys 
                165                 170                 175     


Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr 
225                 230                 235                 240 


Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
            260                 265                 270         


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        275                 280                 285             


Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asp Met Ser Trp Val Arg 
    290                 295                 300                 


Gln Ala Pro Gly Lys Gly Leu Ala Trp Ile Gly Ala Ser Tyr Ala Ser 
305                 310                 315                 320 


Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly Trp Thr Gly 
        355                 360                 365             


Thr Ser His Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu Val 
385                 390                 395                 400 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                405                 410                 415     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala Met 
            420                 425                 430         


Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly His 
        435                 440                 445             


Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly 
                485                 490                 495     


Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln Gly Thr 
            500                 505                 510         


Leu Val Thr Val Ser Ser 
        515             


<210>  99
<211>  486
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  99

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu 
145                 150                 155                 160 


Ser Arg Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Leu Asp 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
    210                 215                 220                 


Val Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
            260                 265                 270         


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser 
        275                 280                 285             


Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
    290                 295                 300                 


Ile Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 
305                 310                 315                 320 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
                325                 330                 335     


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser 
            340                 345                 350         


Thr Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    370                 375                 380                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser 
385                 390                 395                 400 


Val Phe Ser Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln 
                405                 410                 415     


Ser Pro Lys Arg Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val 
            420                 425                 430         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        435                 440                 445             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly 
    450                 455                 460                 


Ser Tyr Ala Cys Ser Ser Ala Asp Cys Tyr Val Phe Gly Thr Gly Thr 
465                 470                 475                 480 


Lys Val Thr Val Leu Gly 
                485     


<210>  100
<211>  509
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  100

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu 
145                 150                 155                 160 


Ser Arg Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Leu Asp 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
    210                 215                 220                 


Val Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser 
        275                 280                 285             


Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Trp 
    290                 295                 300                 


Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp Ala 
305                 310                 315                 320 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
                325                 330                 335     


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys 
            340                 345                 350         


Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly Gln 
        355                 360                 365             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                405                 410                 415     


Ser Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
            420                 425                 430         


Cys Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr 
        435                 440                 445             


Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    450                 455                 460                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
465                 470                 475                 480 


Val Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe 
                485                 490                 495     


Lys Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 


<210>  101
<211>  486
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  101

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu 
145                 150                 155                 160 


Ser Arg Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
                165                 170                 175     


Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Leu Asp 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
    210                 215                 220                 


Val Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
            260                 265                 270         


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser 
        275                 280                 285             


Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
    290                 295                 300                 


Ile Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 
305                 310                 315                 320 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
                325                 330                 335     


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser 
            340                 345                 350         


Thr Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    370                 375                 380                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser 
385                 390                 395                 400 


Val Phe Ser Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln 
                405                 410                 415     


Ser Pro Lys Arg Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val 
            420                 425                 430         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        435                 440                 445             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly 
    450                 455                 460                 


Ser Tyr Ala Cys Ser Ser Ala Asp Cys Tyr Val Phe Gly Thr Gly Thr 
465                 470                 475                 480 


Lys Val Thr Val Leu Gly 
                485     


<210>  102
<211>  509
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  102

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu 
145                 150                 155                 160 


Ser Arg Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
                165                 170                 175     


Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Leu Asp 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
    210                 215                 220                 


Val Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser 
        275                 280                 285             


Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Trp 
    290                 295                 300                 


Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp Ala 
305                 310                 315                 320 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
                325                 330                 335     


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys 
            340                 345                 350         


Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly Gln 
        355                 360                 365             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                405                 410                 415     


Ser Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
            420                 425                 430         


Cys Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr 
        435                 440                 445             


Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    450                 455                 460                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
465                 470                 475                 480 


Val Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe 
                485                 490                 495     


Lys Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 


<210>  103
<211>  488
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  103

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Ser Leu 
145                 150                 155                 160 


Ser Arg Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Phe Cys Val Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile 
        275                 280                 285             


Asn Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly 
            340                 345                 350         


Ser Ser Thr Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    370                 375                 380                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
385                 390                 395                 400 


Gln Ser Val Phe Ser Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro 
                405                 410                 415     


Gly Gln Ser Pro Lys Arg Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser 
            420                 425                 430         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        435                 440                 445             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    450                 455                 460                 


Leu Gly Ser Tyr Ala Cys Ser Ser Ala Asp Cys Tyr Val Phe Gly Thr 
465                 470                 475                 480 


Gly Thr Lys Val Thr Val Leu Gly 
                485             


<210>  104
<211>  511
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  104

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Ser Leu 
145                 150                 155                 160 


Ser Arg Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Phe Cys Val Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            260                 265                 270         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
        275                 280                 285             


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    290                 295                 300                 


Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser 
305                 310                 315                 320 


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                325                 330                 335     


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
            340                 345                 350         


Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp 
        355                 360                 365             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly Gly 
385                 390                 395                 400 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                405                 410                 415     


Gly Phe Ser Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Cys Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala 
        435                 440                 445             


Tyr Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly 
                485                 490                 495     


Pro Phe Lys Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 510     


<210>  105
<211>  488
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  105

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Ser Leu 
145                 150                 155                 160 


Ser Arg Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
                165                 170                 175     


Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Phe Cys Val Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile 
        275                 280                 285             


Asn Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly 
            340                 345                 350         


Ser Ser Thr Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    370                 375                 380                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
385                 390                 395                 400 


Gln Ser Val Phe Ser Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro 
                405                 410                 415     


Gly Gln Ser Pro Lys Arg Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser 
            420                 425                 430         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        435                 440                 445             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    450                 455                 460                 


Leu Gly Ser Tyr Ala Cys Ser Ser Ala Asp Cys Tyr Val Phe Gly Thr 
465                 470                 475                 480 


Gly Thr Lys Val Thr Val Leu Gly 
                485             


<210>  106
<211>  511
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  106

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Ser Leu 
145                 150                 155                 160 


Ser Arg Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
                165                 170                 175     


Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Phe Cys Val Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            260                 265                 270         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
        275                 280                 285             


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    290                 295                 300                 


Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser 
305                 310                 315                 320 


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                325                 330                 335     


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
            340                 345                 350         


Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp 
        355                 360                 365             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly Gly 
385                 390                 395                 400 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                405                 410                 415     


Gly Phe Ser Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Cys Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala 
        435                 440                 445             


Tyr Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly 
                485                 490                 495     


Pro Phe Lys Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 510     


<210>  107
<211>  758
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  107

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro 
        115                 120                 125             


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
    130                 135                 140                 


Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala 
145                 150                 155                 160 


Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp 
                165                 170                 175     


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
            180                 185                 190         


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
        195                 200                 205             


Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly 
    210                 215                 220                 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                245                 250                 255     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            260                 265                 270         


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
        275                 280                 285             


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
    290                 295                 300                 


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
                325                 330                 335     


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
            340                 345                 350         


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val 
    370                 375                 380                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
385                 390                 395                 400 


Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys 
                405                 410                 415     


Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala 
            420                 425                 430         


Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        435                 440                 445             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    450                 455                 460                 


Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys 
465                 470                 475                 480 


Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Asp Val Gln Met Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        515                 520                 525             


Glu Asn Ile Tyr Ser Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    530                 535                 540                 


Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val 
545                 550                 555                 560 


Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                565                 570                 575     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly 
            580                 585                 590         


Gly Tyr Tyr Ser Ser Ser Ser Thr Tyr Ile Ala Phe Gly Thr Gly Thr 
        595                 600                 605             


Lys Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Gln Val Val Glu 
625                 630                 635                 640 


Ser Gly Gly Gly Arg Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                645                 650                 655     


Ala Val Ser Gly Phe Asp Leu Ser Ser Tyr Ala Val Ser Trp Val Arg 
            660                 665                 670         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg 
        675                 680                 685             


Ala Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
    690                 695                 700                 


Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
705                 710                 715                 720 


Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser 
                725                 730                 735     


Gly Ala Tyr Leu Tyr Thr Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr 
            740                 745                 750         


Gln Val Thr Val Ser Ser 
        755             


<210>  108
<211>  751
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  108

Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr 
                85                  90                  95      


Thr Thr Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro 
        115                 120                 125             


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
    130                 135                 140                 


Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala 
145                 150                 155                 160 


Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp 
                165                 170                 175     


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
            180                 185                 190         


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
        195                 200                 205             


Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly 
    210                 215                 220                 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                245                 250                 255     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            260                 265                 270         


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
        275                 280                 285             


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
    290                 295                 300                 


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
                325                 330                 335     


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
            340                 345                 350         


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
        355                 360                 365             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val 
    370                 375                 380                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
385                 390                 395                 400 


Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys 
                405                 410                 415     


Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala 
            420                 425                 430         


Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        435                 440                 445             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    450                 455                 460                 


Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys 
465                 470                 475                 480 


Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser 
            500                 505                 510         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        515                 520                 525             


Gln Asn Val Trp Asn Asn Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro 
    530                 535                 540                 


Gly Lys Pro Pro Lys Leu Leu Ile Val Thr Ala Ser Thr Leu Ala Ser 
545                 550                 555                 560 


Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Ala Gly Gly Phe Ser Gly Glu Ile Arg Ala Phe Gly Cys Gly Thr Lys 
        595                 600                 605             


Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Gln Leu Val Glu Ser 
625                 630                 635                 640 


Gly Gly Gly Arg Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                645                 650                 655     


Val Ser Gly Leu Ser Leu Ser Arg Asn Ala Met Ser Trp Val Arg Gln 
            660                 665                 670         


Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly 
        675                 680                 685             


Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys 
    690                 695                 700                 


Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala 
705                 710                 715                 720 


Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Gly Ile Ala Ser Ser Ser 
                725                 730                 735     


Leu Lys Ser Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            740                 745                 750     


<210>  109
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  109

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Gln Val Val Glu Ser Gly Gly Gly Arg Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp 
145                 150                 155                 160 


Leu Ser Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr 
225                 230                 235                 240 


Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Glu Leu Thr Gln 
            260                 265                 270         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        275                 280                 285             


Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg Leu Ala Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu 
305                 310                 315                 320 


Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                325                 330                 335     


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr Thr Thr Phe Gly Cys Gly 
        355                 360                 365             


Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
                405                 410                 415     


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
            420                 425                 430         


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        435                 440                 445             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    450                 455                 460                 


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
465                 470                 475                 480 


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                485                 490                 495 


<210>  110
<211>  518
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  110

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Gln Val Val Glu Ser Gly Gly Gly Arg Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp 
145                 150                 155                 160 


Leu Ser Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr 
225                 230                 235                 240 


Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
            260                 265                 270         


Ser Gly Gly Gly Arg Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        275                 280                 285             


Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asp Met Ser Trp Val Arg 
    290                 295                 300                 


Gln Ala Pro Gly Lys Gly Leu Ala Trp Ile Gly Ala Ser Tyr Ala Ser 
305                 310                 315                 320 


Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly Trp Thr Gly 
        355                 360                 365             


Thr Ser His Ser Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu Val 
385                 390                 395                 400 


Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly Ser Leu 
                405                 410                 415     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala Met 
            420                 425                 430         


Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly His 
        435                 440                 445             


Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                485                 490                 495     


Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln Gly Thr 
            500                 505                 510         


Gln Val Thr Val Ser Ser 
        515             


<210>  111
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  111

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Gln Val Val Glu Ser Gly Gly Gly Arg Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp 
145                 150                 155                 160 


Leu Ser Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Cys 
                165                 170                 175     


Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr 
225                 230                 235                 240 


Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Glu Leu Thr Gln 
            260                 265                 270         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        275                 280                 285             


Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg Leu Ala Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu 
305                 310                 315                 320 


Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                325                 330                 335     


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr Thr Thr Phe Gly Cys Gly 
        355                 360                 365             


Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
                405                 410                 415     


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
            420                 425                 430         


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        435                 440                 445             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    450                 455                 460                 


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
465                 470                 475                 480 


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                485                 490                 495 


<210>  112
<211>  518
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  112

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Gln Val Val Glu Ser Gly Gly Gly Arg Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp 
145                 150                 155                 160 


Leu Ser Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Cys 
                165                 170                 175     


Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr 
225                 230                 235                 240 


Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
            260                 265                 270         


Ser Gly Gly Gly Arg Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        275                 280                 285             


Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asp Met Ser Trp Val Arg 
    290                 295                 300                 


Gln Ala Pro Gly Lys Gly Leu Ala Trp Ile Gly Ala Ser Tyr Ala Ser 
305                 310                 315                 320 


Gly Pro Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly Trp Thr Gly 
        355                 360                 365             


Thr Ser His Ser Asn Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu Val 
385                 390                 395                 400 


Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly Ser Leu 
                405                 410                 415     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala Met 
            420                 425                 430         


Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly His 
        435                 440                 445             


Ile Asn Ala Gly Asp Ile Ala Tyr Tyr Ala Thr Trp Ala Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                485                 490                 495     


Ala Gly Gly Phe Ser Thr Gly Pro Phe Lys Leu Trp Gly Gln Gly Thr 
            500                 505                 510         


Gln Val Thr Val Ser Ser 
        515             


<210>  113
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  113

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Gln Val Val Glu Ser Gly Gly Gly Arg Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp 
145                 150                 155                 160 


Leu Ser Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr 
225                 230                 235                 240 


Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Glu Leu Thr Gln 
            260                 265                 270         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        275                 280                 285             


Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg Leu Ala Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu 
305                 310                 315                 320 


Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                325                 330                 335     


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr Thr Thr Phe Gly Cys Gly 
        355                 360                 365             


Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
                405                 410                 415     


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
            420                 425                 430         


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        435                 440                 445             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    450                 455                 460                 


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
465                 470                 475                 480 


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                485                 490                 495 


<210>  114
<211>  511
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  114

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Ser Leu 
145                 150                 155                 160 


Ser Arg Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
    210                 215                 220                 


Phe Cys Val Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly 
225                 230                 235                 240 


Gln Gly Gln Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln 
            260                 265                 270         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
        275                 280                 285             


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    290                 295                 300                 


Ala Trp Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser 
305                 310                 315                 320 


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                325                 330                 335     


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
            340                 345                 350         


Phe Cys Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp 
        355                 360                 365             


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly Gly 
385                 390                 395                 400 


Gly Arg Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                405                 410                 415     


Gly Phe Ser Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Cys Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala 
        435                 440                 445             


Tyr Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Thr Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly 
                485                 490                 495     


Pro Phe Lys Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            500                 505                 510     


<210>  115
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  115

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Tyr Ile Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Gln Val Val Glu Ser Gly Gly Gly Arg Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp 
145                 150                 155                 160 


Leu Ser Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Ile Ile Tyr Pro Arg Ala Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg Tyr Asp Ser Gly Ala Tyr Leu Tyr Thr 
225                 230                 235                 240 


Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Glu Leu Thr Gln 
            260                 265                 270         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        275                 280                 285             


Cys Gln Ala Ser Glu Ser Ile Asn Ser Arg Leu Ala Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu 
305                 310                 315                 320 


Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                325                 330                 335     


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gly Tyr Gly Gly Ser Ser Thr Thr Thr Phe Gly Cys Gly 
        355                 360                 365             


Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Ser Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Phe Ser Asn Asn Tyr Leu 
                405                 410                 415     


Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
            420                 425                 430         


Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        435                 440                 445             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    450                 455                 460                 


Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Ala Cys Ser Ser Ala 
465                 470                 475                 480 


Asp Cys Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                485                 490                 495 


<210>  116
<211>  509
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence

<400>  116

Ala Gln Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Val Trp Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Val Thr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Gly 
                85                  90                  95      


Glu Ile Arg Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu 
145                 150                 155                 160 


Ser Arg Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Ile Ile Leu Thr Ser Gly Ser Thr Tyr Tyr Ala Ser 
            180                 185                 190         


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Leu Asp 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys 
    210                 215                 220                 


Val Arg Gly Ile Ala Ser Ser Ser Leu Lys Ser Phe Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser 
        275                 280                 285             


Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Trp 
    290                 295                 300                 


Ile Gly Ala Ser Tyr Ala Ser Gly Pro Thr Tyr Tyr Ala Ser Trp Ala 
305                 310                 315                 320 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
                325                 330                 335     


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys 
            340                 345                 350         


Ala Arg Gly Gly Trp Thr Gly Thr Ser His Ser Asn Ile Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg 
385                 390                 395                 400 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                405                 410                 415     


Ser Leu Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
            420                 425                 430         


Cys Leu Glu Trp Ile Gly His Ile Asn Ala Gly Asp Ile Ala Tyr Tyr 
        435                 440                 445             


Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    450                 455                 460                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
465                 470                 475                 480 


Thr Tyr Phe Cys Ala Arg Gly Ala Gly Gly Phe Ser Thr Gly Pro Phe 
                485                 490                 495     


Lys Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            500                 505                 


<210>  117
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  117

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr 
                405     


<210>  118
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence


<220>
<221>  Repeat
<222>  (1)..(5)
<223>  n repeats with n being an integer of at least one

<400>  118

Gly Ser Gly Gly Ser 
1               5   


<210>  119
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence


<220>
<221>  Repeat
<222>  (1)..(5)
<223>  n repeats with n being an integer of at least one

<400>  119

Gly Gly Gly Gly Ser 
1               5   


<210>  120
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence


<220>
<221>  Repeat
<222>  (1)..(4)
<223>  n repeats with n being an integer of at least one

<400>  120

Gly Gly Gly Gly Ser 
1               5   


<210>  121
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence


<220>
<221>  Repeat
<222>  (1)..(5)
<223>  n repeats with n being 1 or 2

<400>  121

Gly Gly Gly Gly Ser 
1               5   


<210>  122
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-based sequence


<220>
<221>  Repeat
<222>  (1)..(5)
<223>  n repeats with n being 1, 2, 3, 4, 5, 6, 7 or 8

<400>  122

Gly Gly Gly Gly Ser 
1               5   


