               SEQUENCE LISTING

<110> Medizinische Universitaet Innsbruck

<120> Improved Cholecystokinin-2 Receptor (CCK2R) Targeting for Diagnosis and Therapy

<130> PCT137971-FZMGpau

<140> EPPCT/
<141> 2021-02-02

<150> PCT/EP2021/052428
<151> 2021-02-02

<160> 7

<170> BiSSAP 1.3.6

<210> 1
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> artificial peptide

<220> 
<223> amidated at the C-terminus

<400> 1
Asp Tyr Met Gly Trp Met Asp Phe 
1               5               

<210> 2
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> artificial peptide

<220> 
<223> amidated at the C-terminus

<400> 2
Leu Glu Glu Glu Glu Glu Ala Tyr Gly Trp Met Asp Phe 
1               5                   10              

<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> DOTA (1,4,7,10-tetraazacyclododecan-1,4,7,10-tetra acetic acid)
      modified D-Glu chelated with 111 Indium

<220> 
<223> 111In-DOTA-MGS1

<220> 
<221> MOD_RES
<222> 8
<223> Xaa = 1-naphtylalanine (1Nal) amidated at the C-terminus

<400> 3
Xaa Ala Tyr Gly Trp Met Asp Xaa 
1               5               

<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> DOTA (1,4,7,10-tetraazacyclododecan-1,4,7,10-tetra acetic acid)
      modified D-Glu chelated with 111 Indium

<220> 
<223> 111In-DOTA-MGS4

<220> 
<221> MOD_RES
<222> 6
<223> Xaa = Nle -CONCH3- pseudopeptide bonded to Trp

<220> 
<221> MOD_RES
<222> 8
<223> Xaa = Phenylalanine -CONCH3- pseudopeptide bonded, amidated at
      the C-terminus

<400> 4
Xaa Ala Tyr Gly Trp Xaa Asp Xaa 
1               5               

<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> DOTA (1,4,7,10-tetraazacyclododecan-1,4,7,10-tetra acetic acid)
      modified D-Glu

<220> 
<223> DOTA-MGS5

<220> 
<221> MOD_RES
<222> 6
<223> Xaa = Nle -CONCH3- pseudopeptide bonded to Trp

<220> 
<221> MOD_RES
<222> 8
<223> Xaa = 1-naphtylalanine (1Nal) amidated at the C-terminus

<400> 5
Xaa Ala Tyr Gly Trp Xaa Asp Xaa 
1               5               

<210> 6
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> beta-Alanine optionally having attached DOTA by a linker, linker
      may be 2x GABOB, 2x GABA, 1x DGlu or 2x gamma-DGlu

<220> 
<223> peptidomimetic binding to CCK2R

<220> 
<221> MOD_RES
<222> 3
<223> Xaa = Nle -CONCH3- pseudopeptide bonded to Trp

<220> 
<221> MOD_RES
<222> 5
<223> Xaa = 1Nal

<400> 6
Xaa Trp Xaa Asp Xaa 
1               5   

<210> 7
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> beta-Alanine having attached DOTA by linker, linker may be 
      2x GABOB, 2x GABA, 1x DGlu or 2x gamma-DGlu, DOTA being
      chelated with either 68Ga or 177Lu

<220> 
<223> radionuclide chelated peptidomimetic binding to CCK2R

<220> 
<221> MOD_RES
<222> 3
<223> Xaa = Nle -CONCH3- pseudopeptide bonded to Trp

<220> 
<221> MOD_RES
<222> 5
<223> Xaa = 1Nal, amidated at C-terminus

<400> 7
Xaa Trp Xaa Asp Xaa 
1               5   

