                         SEQUENCE LISTING

<110>  OSPEDALE SAN RAFFAELE S.R.L.
       FONDAZIONE CENTRO SAN RAFFAELE
       ISTITUTO EUROPEO DI ONCOLOGIA S.R.L.
 
<120>  ENGINEERED TRANSPOSASE AND USES THEREOF

<130>  P121569PCT

<140>  PCT/EP2022/052915
<141>  2022-02-07

<150>  GB2101656.3
<151>  2021-02-05

<150>  GB2109803.3
<151>  2021-07-07

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Met Gly Lys Lys Thr Lys Arg Thr Ala Asp Ser Ser Ser Ser Glu Asp 
1               5                   10                  15      


Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys 
            20                  25                  30          


Gly Gln Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Glu Glu His 
        35                  40                  45              


Asn Thr Trp Glu Pro Glu Lys Asn Leu Asp Cys Pro Glu Leu Ile Ser 
    50                  55                  60                  


Glu Phe Met Lys Lys Tyr Lys Lys Met Lys Glu Gly Glu Asn Asn Lys 
65                  70                  75                  80  


Pro Arg Glu Lys Ser Glu Ser Asn Lys Arg Lys Ser Asn Phe Ser Asn 
                85                  90                  95      


Ser Ala Asp Asp Ile Lys Ser Lys Lys Lys Arg Glu Gln Ser Asn Asp 
            100                 105                 110         


Thr Gly Ser Thr Gly Ser Thr Gly Ser His Met Ile Thr Ser Ala Leu 
        115                 120                 125             


His Arg Ala Ala Asp Trp Ala Lys Ser Val Phe Ser Ser Ala Ala Leu 
    130                 135                 140                 


Gly Asp Pro Arg Arg Thr Ala Arg Leu Val Asn Val Ala Ala Gln Leu 
145                 150                 155                 160 


Ala Lys Tyr Ser Gly Lys Ser Ile Thr Ile Ser Ser Glu Gly Ser Lys 
                165                 170                 175     


Ala Met Gln Glu Gly Ala Tyr Arg Phe Ile Arg Asn Pro Asn Val Ser 
            180                 185                 190         


Ala Glu Ala Ile Arg Lys Ala Gly Ala Met Gln Thr Val Lys Leu Ala 
        195                 200                 205             


Gln Glu Phe Pro Glu Leu Leu Ala Ile Glu Asp Thr Thr Ser Leu Ser 
    210                 215                 220                 


Tyr Arg His Gln Val Ala Glu Glu Leu Gly Lys Leu Gly Ser Ile Gln 
225                 230                 235                 240 


Asp Lys Ser Arg Gly Trp Trp Val His Ser Val Leu Leu Leu Glu Ala 
                245                 250                 255     


Thr Thr Phe Arg Thr Val Gly Leu Leu His Gln Glu Trp Trp Met Arg 
            260                 265                 270         


Pro Asp Asp Pro Ala Asp Ala Asp Glu Lys Glu Ser Gly Lys Trp Leu 
        275                 280                 285             


Ala Ala Ala Ala Thr Ser Arg Leu Arg Met Gly Ser Met Met Ser Asn 
    290                 295                 300                 


Val Ile Ala Val Cys Asp Arg Glu Ala Asp Ile His Ala Tyr Leu Gln 
305                 310                 315                 320 


Asp Lys Leu Ala His Asn Glu Arg Phe Val Val Arg Ser Lys His Pro 
                325                 330                 335     


Arg Lys Asp Val Glu Ser Gly Leu Tyr Leu Tyr Asp His Leu Lys Asn 
            340                 345                 350         


Gln Pro Glu Leu Gly Gly Tyr Gln Ile Ser Ile Pro Gln Lys Gly Val 
        355                 360                 365             


Val Asp Lys Arg Gly Lys Arg Lys Asn Arg Pro Ala Arg Lys Ala Ser 
    370                 375                 380                 


Leu Ser Leu Arg Ser Gly Arg Ile Thr Leu Lys Gln Gly Asn Ile Thr 
385                 390                 395                 400 


Leu Asn Ala Val Leu Ala Glu Glu Ile Asn Pro Pro Lys Gly Glu Thr 
                405                 410                 415     


Pro Leu Lys Trp Leu Leu Leu Thr Ser Glu Pro Val Glu Ser Leu Ala 
            420                 425                 430         


Gln Ala Leu Arg Val Ile Asp Ile Tyr Thr His Arg Trp Arg Ile Glu 
        435                 440                 445             


Glu Phe His Lys Ala Trp Lys Thr Gly Ala Gly Ala Glu Arg Gln Arg 
    450                 455                 460                 


Met Glu Glu Pro Asp Asn Leu Glu Arg Met Val Ser Ile Leu Ser Phe 
465                 470                 475                 480 


Val Ala Val Arg Leu Leu Gln Leu Arg Glu Ser Phe Thr Pro Pro Gln 
                485                 490                 495     


Ala Leu Arg Ala Gln Gly Leu Leu Lys Glu Ala Glu His Val Glu Ser 
            500                 505                 510         


Gln Ser Ala Glu Thr Val Leu Thr Pro Asp Glu Cys Gln Leu Leu Gly 
        515                 520                 525             


Tyr Leu Asp Lys Gly Lys Arg Lys Arg Lys Glu Lys Ala Gly Ser Leu 
    530                 535                 540                 


Gln Trp Ala Tyr Met Ala Ile Ala Arg Leu Gly Gly Phe Met Asp Ser 
545                 550                 555                 560 


Lys Arg Thr Gly Ile Ala Ser Trp Gly Ala Leu Trp Glu Gly Trp Glu 
                565                 570                 575     


Ala Leu Gln Ser Lys Leu Asp Gly Phe Leu Ala Ala Lys Asp Leu Met 
            580                 585                 590         


Ala Gln Gly Ile Lys Ile Cys 
        595                 


<210>  2
<211>  1797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
atgggaaaga aaaccaagcg gacagctgac agttcttctt cagaggatga ggaggagtat       60

gttgtggaga aggtgctaga caggcgcgtg gttaagggac aagtggaata tctactgaag      120

tggaaaggct tttctgagga gcacaatact tgggaacctg agaaaaactt ggattgccct      180

gagctaattt ctgaatttat gaaaaagtat aagaagatga aggagggtga aaataataaa      240

cccagggaga agtcagaaag taacaagagg aaatccaatt tctcaaacag tgccgatgac      300

atcaaatcta aaaaaaagag agagcagagc aatgatacgg ggtcgaccgg ctcaactggt      360

tcccatatga ttaccagtgc actgcatcgt gcggcggatt gggcgaaaag cgtgttttct      420

agtgctgcgc tgggtgatcc gcgtcgtacc gcgcgtctgg tgaatgttgc ggcgcaactg      480

gccaaatata gcggcaaaag cattaccatt agcagcgaag gcagcaaagc catgcaggaa      540

ggcgcgtatc gttttattcg taatccgaac gtgagcgcgg aagcgattcg taaagcgggt      600

gccatgcaga ccgtgaaact ggcccaggaa tttccggaac tgctggcaat tgaagatacc      660

acctctctga gctatcgtca tcaggtggcg gaagaactgg gcaaactggg tagcattcag      720

gataaaagcc gtggttggtg ggtgcatagc gtgctgctgc tggaagcgac cacctttcgt      780

accgtgggcc tgctgcatca agaatggtgg atgcgtccgg atgatccggc ggatgcggat      840

gaaaaagaaa gcggcaaatg gctggccgct gctgcaactt cgcgtctgag aatgggcagc      900

atgatgagca acgtgattgc ggtgtgcgat cgtgaagcgg atattcatgc gtatctgcaa      960

gataaactgg cccataacga acgttttgtg gtgcgtagca aacatccgcg taaagatgtg     1020

gaaagcggcc tgtatctgta tgatcacctg aaaaaccagc cggaactggg cggctatcag     1080

attagcattc cgcagaaagg cgtggtggat aaacgtggca aacgtaaaaa ccgtccggcg     1140

cgtaaagcga gcctgagcct gcgtagcggc cgtattaccc tgaaacaggg caacattacc     1200

ctgaacgcgg tgctggccga agaaattaat ccgccgaaag gcgaaacccc gctgaaatgg     1260

ctgctgctga ccagcgagcc ggtggaaagt ctggcccaag cgctgcgtgt gattgatatt     1320

tatacccatc gttggcgcat tgaagaattt cacaaagcgt ggaaaacggg tgcgggtgcg     1380

gaacgtcagc gtatggaaga accggataac ctggaacgta tggtgagcat tctgagcttt     1440

gtggcggtgc gtctgctgca actgcgtgaa tcttttactc cgccgcaagc actgcgtgcg     1500

cagggcctgc tgaaagaagc ggaacacgtt gaaagccaga gcgcggaaac cgtgctgacc     1560

ccggatgaat gccaactgct gggctatctg gataaaggca aacgcaaacg caaagaaaaa     1620

gcgggcagcc tgcaatgggc gtatatggcg attgcgcgtc tgggcggctt tatggatagc     1680

aaacgtaccg gcattgcgag ctggggtgcg ctgtgggaag gttgggaagc gctgcaaagc     1740

aaactggatg gctttctggc cgcgaaagac ctgatggcgc agggcattaa aatctgc        1797


<210>  3
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Met Gly Lys Lys Thr Lys Arg Thr Ala Asp Ser Ser Ser Ser Glu Asp 
1               5                   10                  15      


Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys 
            20                  25                  30          


Gly Gln Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Glu Glu His 
        35                  40                  45              


Asn Thr Trp Glu Pro Glu Lys Asn Leu Asp Cys Pro Glu Leu Ile Ser 
    50                  55                  60                  


Glu Phe Met Lys Lys Tyr Lys Lys Met Lys Glu Gly Glu Asn Asn Lys 
65                  70                  75                  80  


Pro Arg Glu Lys Ser Glu Ser Asn Lys Arg Lys Ser Asn Thr Gly Ser 
                85                  90                  95      


Thr Gly Ser Thr Gly Ser His Met Ile Thr Ser Ala Leu His Arg Ala 
            100                 105                 110         


Ala Asp Trp Ala Lys Ser Val Phe Ser Ser Ala Ala Leu Gly Asp Pro 
        115                 120                 125             


Arg Arg Thr Ala Arg Leu Val Asn Val Ala Ala Gln Leu Ala Lys Tyr 
    130                 135                 140                 


Ser Gly Lys Ser Ile Thr Ile Ser Ser Glu Gly Ser Lys Ala Met Gln 
145                 150                 155                 160 


Glu Gly Ala Tyr Arg Phe Ile Arg Asn Pro Asn Val Ser Ala Glu Ala 
                165                 170                 175     


Ile Arg Lys Ala Gly Ala Met Gln Thr Val Lys Leu Ala Gln Glu Phe 
            180                 185                 190         


Pro Glu Leu Leu Ala Ile Glu Asp Thr Thr Ser Leu Ser Tyr Arg His 
        195                 200                 205             


Gln Val Ala Glu Glu Leu Gly Lys Leu Gly Ser Ile Gln Asp Lys Ser 
    210                 215                 220                 


Arg Gly Trp Trp Val His Ser Val Leu Leu Leu Glu Ala Thr Thr Phe 
225                 230                 235                 240 


Arg Thr Val Gly Leu Leu His Gln Glu Trp Trp Met Arg Pro Asp Asp 
                245                 250                 255     


Pro Ala Asp Ala Asp Glu Lys Glu Ser Gly Lys Trp Leu Ala Ala Ala 
            260                 265                 270         


Ala Thr Ser Arg Leu Arg Met Gly Ser Met Met Ser Asn Val Ile Ala 
        275                 280                 285             


Val Cys Asp Arg Glu Ala Asp Ile His Ala Tyr Leu Gln Asp Lys Leu 
    290                 295                 300                 


Ala His Asn Glu Arg Phe Val Val Arg Ser Lys His Pro Arg Lys Asp 
305                 310                 315                 320 


Val Glu Ser Gly Leu Tyr Leu Tyr Asp His Leu Lys Asn Gln Pro Glu 
                325                 330                 335     


Leu Gly Gly Tyr Gln Ile Ser Ile Pro Gln Lys Gly Val Val Asp Lys 
            340                 345                 350         


Arg Gly Lys Arg Lys Asn Arg Pro Ala Arg Lys Ala Ser Leu Ser Leu 
        355                 360                 365             


Arg Ser Gly Arg Ile Thr Leu Lys Gln Gly Asn Ile Thr Leu Asn Ala 
    370                 375                 380                 


Val Leu Ala Glu Glu Ile Asn Pro Pro Lys Gly Glu Thr Pro Leu Lys 
385                 390                 395                 400 


Trp Leu Leu Leu Thr Ser Glu Pro Val Glu Ser Leu Ala Gln Ala Leu 
                405                 410                 415     


Arg Val Ile Asp Ile Tyr Thr His Arg Trp Arg Ile Glu Glu Phe His 
            420                 425                 430         


Lys Ala Trp Lys Thr Gly Ala Gly Ala Glu Arg Gln Arg Met Glu Glu 
        435                 440                 445             


Pro Asp Asn Leu Glu Arg Met Val Ser Ile Leu Ser Phe Val Ala Val 
    450                 455                 460                 


Arg Leu Leu Gln Leu Arg Glu Ser Phe Thr Pro Pro Gln Ala Leu Arg 
465                 470                 475                 480 


Ala Gln Gly Leu Leu Lys Glu Ala Glu His Val Glu Ser Gln Ser Ala 
                485                 490                 495     


Glu Thr Val Leu Thr Pro Asp Glu Cys Gln Leu Leu Gly Tyr Leu Asp 
            500                 505                 510         


Lys Gly Lys Arg Lys Arg Lys Glu Lys Ala Gly Ser Leu Gln Trp Ala 
        515                 520                 525             


Tyr Met Ala Ile Ala Arg Leu Gly Gly Phe Met Asp Ser Lys Arg Thr 
    530                 535                 540                 


Gly Ile Ala Ser Trp Gly Ala Leu Trp Glu Gly Trp Glu Ala Leu Gln 
545                 550                 555                 560 


Ser Lys Leu Asp Gly Phe Leu Ala Ala Lys Asp Leu Met Ala Gln Gly 
                565                 570                 575     


Ile Lys Ile Cys 
            580 


<210>  4
<211>  1740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
atgggaaaga aaaccaagcg gacagctgac agttcttctt cagaggatga ggaggagtat       60

gttgtggaga aggtgctaga caggcgcgtg gttaagggac aagtggaata tctactgaag      120

tggaaaggct tttctgagga gcacaatact tgggaacctg agaaaaactt ggattgccct      180

gagctaattt ctgaatttat gaaaaagtat aagaagatga aggagggtga aaataataaa      240

cccagggaga agtcagaaag taacaagagg aaatccaata cggggtcgac cggctcaact      300

ggttcccata tgattaccag tgcactgcat cgtgcggcgg attgggcgaa aagcgtgttt      360

tctagtgctg cgctgggtga tccgcgtcgt accgcgcgtc tggtgaatgt tgcggcgcaa      420

ctggccaaat atagcggcaa aagcattacc attagcagcg aaggcagcaa agccatgcag      480

gaaggcgcgt atcgttttat tcgtaatccg aacgtgagcg cggaagcgat tcgtaaagcg      540

ggtgccatgc agaccgtgaa actggcccag gaatttccgg aactgctggc aattgaagat      600

accacctctc tgagctatcg tcatcaggtg gcggaagaac tgggcaaact gggtagcatt      660

caggataaaa gccgtggttg gtgggtgcat agcgtgctgc tgctggaagc gaccaccttt      720

cgtaccgtgg gcctgctgca tcaagaatgg tggatgcgtc cggatgatcc ggcggatgcg      780

gatgaaaaag aaagcggcaa atggctggcc gctgctgcaa cttcgcgtct gagaatgggc      840

agcatgatga gcaacgtgat tgcggtgtgc gatcgtgaag cggatattca tgcgtatctg      900

caagataaac tggcccataa cgaacgtttt gtggtgcgta gcaaacatcc gcgtaaagat      960

gtggaaagcg gcctgtatct gtatgatcac ctgaaaaacc agccggaact gggcggctat     1020

cagattagca ttccgcagaa aggcgtggtg gataaacgtg gcaaacgtaa aaaccgtccg     1080

gcgcgtaaag cgagcctgag cctgcgtagc ggccgtatta ccctgaaaca gggcaacatt     1140

accctgaacg cggtgctggc cgaagaaatt aatccgccga aaggcgaaac cccgctgaaa     1200

tggctgctgc tgaccagcga gccggtggaa agtctggccc aagcgctgcg tgtgattgat     1260

atttataccc atcgttggcg cattgaagaa tttcacaaag cgtggaaaac gggtgcgggt     1320

gcggaacgtc agcgtatgga agaaccggat aacctggaac gtatggtgag cattctgagc     1380

tttgtggcgg tgcgtctgct gcaactgcgt gaatctttta ctccgccgca agcactgcgt     1440

gcgcagggcc tgctgaaaga agcggaacac gttgaaagcc agagcgcgga aaccgtgctg     1500

accccggatg aatgccaact gctgggctat ctggataaag gcaaacgcaa acgcaaagaa     1560

aaagcgggca gcctgcaatg ggcgtatatg gcgattgcgc gtctgggcgg ctttatggat     1620

agcaaacgta ccggcattgc gagctggggt gcgctgtggg aaggttggga agcgctgcaa     1680

agcaaactgg atggctttct ggccgcgaaa gacctgatgg cgcagggcat taaaatctgc     1740


<210>  5
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Gly Lys Lys Thr Lys Arg Thr Ala Asp Ser Ser Ser Ser Glu Asp 
1               5                   10                  15      


Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys 
            20                  25                  30          


Gly Gln Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Glu Glu His 
        35                  40                  45              


Asn Thr Trp Glu Pro Glu Lys Asn Leu Asp Cys Pro Glu Leu Ile Ser 
    50                  55                  60                  


Glu Phe Met Lys Lys Tyr Lys Lys Met Lys Glu Gly Glu Asn Asn Lys 
65                  70                  75                  80  


Pro Arg Glu Lys Ser Glu Ser Asn Lys Arg Lys Ser Asn Thr Gly Ser 
                85                  90                  95      


Thr Gly Ser Thr Gly Ser Thr Gly Ser Thr Gly Ser His Met Ile Thr 
            100                 105                 110         


Ser Ala Leu His Arg Ala Ala Asp Trp Ala Lys Ser Val Phe Ser Ser 
        115                 120                 125             


Ala Ala Leu Gly Asp Pro Arg Arg Thr Ala Arg Leu Val Asn Val Ala 
    130                 135                 140                 


Ala Gln Leu Ala Lys Tyr Ser Gly Lys Ser Ile Thr Ile Ser Ser Glu 
145                 150                 155                 160 


Gly Ser Lys Ala Met Gln Glu Gly Ala Tyr Arg Phe Ile Arg Asn Pro 
                165                 170                 175     


Asn Val Ser Ala Glu Ala Ile Arg Lys Ala Gly Ala Met Gln Thr Val 
            180                 185                 190         


Lys Leu Ala Gln Glu Phe Pro Glu Leu Leu Ala Ile Glu Asp Thr Thr 
        195                 200                 205             


Ser Leu Ser Tyr Arg His Gln Val Ala Glu Glu Leu Gly Lys Leu Gly 
    210                 215                 220                 


Ser Ile Gln Asp Lys Ser Arg Gly Trp Trp Val His Ser Val Leu Leu 
225                 230                 235                 240 


Leu Glu Ala Thr Thr Phe Arg Thr Val Gly Leu Leu His Gln Glu Trp 
                245                 250                 255     


Trp Met Arg Pro Asp Asp Pro Ala Asp Ala Asp Glu Lys Glu Ser Gly 
            260                 265                 270         


Lys Trp Leu Ala Ala Ala Ala Thr Ser Arg Leu Arg Met Gly Ser Met 
        275                 280                 285             


Met Ser Asn Val Ile Ala Val Cys Asp Arg Glu Ala Asp Ile His Ala 
    290                 295                 300                 


Tyr Leu Gln Asp Lys Leu Ala His Asn Glu Arg Phe Val Val Arg Ser 
305                 310                 315                 320 


Lys His Pro Arg Lys Asp Val Glu Ser Gly Leu Tyr Leu Tyr Asp His 
                325                 330                 335     


Leu Lys Asn Gln Pro Glu Leu Gly Gly Tyr Gln Ile Ser Ile Pro Gln 
            340                 345                 350         


Lys Gly Val Val Asp Lys Arg Gly Lys Arg Lys Asn Arg Pro Ala Arg 
        355                 360                 365             


Lys Ala Ser Leu Ser Leu Arg Ser Gly Arg Ile Thr Leu Lys Gln Gly 
    370                 375                 380                 


Asn Ile Thr Leu Asn Ala Val Leu Ala Glu Glu Ile Asn Pro Pro Lys 
385                 390                 395                 400 


Gly Glu Thr Pro Leu Lys Trp Leu Leu Leu Thr Ser Glu Pro Val Glu 
                405                 410                 415     


Ser Leu Ala Gln Ala Leu Arg Val Ile Asp Ile Tyr Thr His Arg Trp 
            420                 425                 430         


Arg Ile Glu Glu Phe His Lys Ala Trp Lys Thr Gly Ala Gly Ala Glu 
        435                 440                 445             


Arg Gln Arg Met Glu Glu Pro Asp Asn Leu Glu Arg Met Val Ser Ile 
    450                 455                 460                 


Leu Ser Phe Val Ala Val Arg Leu Leu Gln Leu Arg Glu Ser Phe Thr 
465                 470                 475                 480 


Pro Pro Gln Ala Leu Arg Ala Gln Gly Leu Leu Lys Glu Ala Glu His 
                485                 490                 495     


Val Glu Ser Gln Ser Ala Glu Thr Val Leu Thr Pro Asp Glu Cys Gln 
            500                 505                 510         


Leu Leu Gly Tyr Leu Asp Lys Gly Lys Arg Lys Arg Lys Glu Lys Ala 
        515                 520                 525             


Gly Ser Leu Gln Trp Ala Tyr Met Ala Ile Ala Arg Leu Gly Gly Phe 
    530                 535                 540                 


Met Asp Ser Lys Arg Thr Gly Ile Ala Ser Trp Gly Ala Leu Trp Glu 
545                 550                 555                 560 


Gly Trp Glu Ala Leu Gln Ser Lys Leu Asp Gly Phe Leu Ala Ala Lys 
                565                 570                 575     


Asp Leu Met Ala Gln Gly Ile Lys Ile Cys 
            580                 585     


<210>  6
<211>  1758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
atgggaaaga aaaccaagcg gacagctgac agttcttctt cagaggatga ggaggagtat       60

gttgtggaga aggtgctaga caggcgcgtg gttaagggac aagtggaata tctactgaag      120

tggaaaggct tttctgagga gcacaatact tgggaacctg agaaaaactt ggattgccct      180

gagctaattt ctgaatttat gaaaaagtat aagaagatga aggagggtga aaataataaa      240

cccagggaga agtcagaaag taacaagagg aaatccaata cggggtcgac cggctcaact      300

ggttccaccg ggtccacggg ctcgcatatg attaccagtg cactgcatcg tgcggcggat      360

tgggcgaaaa gcgtgttttc tagtgctgcg ctgggtgatc cgcgtcgtac cgcgcgtctg      420

gtgaatgttg cggcgcaact ggccaaatat agcggcaaaa gcattaccat tagcagcgaa      480

ggcagcaaag ccatgcagga aggcgcgtat cgttttattc gtaatccgaa cgtgagcgcg      540

gaagcgattc gtaaagcggg tgccatgcag accgtgaaac tggcccagga atttccggaa      600

ctgctggcaa ttgaagatac cacctctctg agctatcgtc atcaggtggc ggaagaactg      660

ggcaaactgg gtagcattca ggataaaagc cgtggttggt gggtgcatag cgtgctgctg      720

ctggaagcga ccacctttcg taccgtgggc ctgctgcatc aagaatggtg gatgcgtccg      780

gatgatccgg cggatgcgga tgaaaaagaa agcggcaaat ggctggccgc tgctgcaact      840

tcgcgtctga gaatgggcag catgatgagc aacgtgattg cggtgtgcga tcgtgaagcg      900

gatattcatg cgtatctgca agataaactg gcccataacg aacgttttgt ggtgcgtagc      960

aaacatccgc gtaaagatgt ggaaagcggc ctgtatctgt atgatcacct gaaaaaccag     1020

ccggaactgg gcggctatca gattagcatt ccgcagaaag gcgtggtgga taaacgtggc     1080

aaacgtaaaa accgtccggc gcgtaaagcg agcctgagcc tgcgtagcgg ccgtattacc     1140

ctgaaacagg gcaacattac cctgaacgcg gtgctggccg aagaaattaa tccgccgaaa     1200

ggcgaaaccc cgctgaaatg gctgctgctg accagcgagc cggtggaaag tctggcccaa     1260

gcgctgcgtg tgattgatat ttatacccat cgttggcgca ttgaagaatt tcacaaagcg     1320

tggaaaacgg gtgcgggtgc ggaacgtcag cgtatggaag aaccggataa cctggaacgt     1380

atggtgagca ttctgagctt tgtggcggtg cgtctgctgc aactgcgtga atcttttact     1440

ccgccgcaag cactgcgtgc gcagggcctg ctgaaagaag cggaacacgt tgaaagccag     1500

agcgcggaaa ccgtgctgac cccggatgaa tgccaactgc tgggctatct ggataaaggc     1560

aaacgcaaac gcaaagaaaa agcgggcagc ctgcaatggg cgtatatggc gattgcgcgt     1620

ctgggcggct ttatggatag caaacgtacc ggcattgcga gctggggtgc gctgtgggaa     1680

ggttgggaag cgctgcaaag caaactggat ggctttctgg ccgcgaaaga cctgatggcg     1740

cagggcatta aaatctgc                                                   1758


<210>  7
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met Gly Lys Lys Thr Lys Arg Thr Ala Asp Ser Ser Ser Ser Glu Asp 
1               5                   10                  15      


Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys 
            20                  25                  30          


Gly Gln Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Glu Glu His 
        35                  40                  45              


Asn Thr Trp Glu Pro Glu Lys Asn Leu Asp Cys Pro Glu Leu Ile Ser 
    50                  55                  60                  


Glu Phe Met Lys Lys Tyr Lys Lys Met Lys Glu Gly Glu Asn Asn Lys 
65                  70                  75                  80  


Pro Arg Glu Lys Ser Glu Ser Asn Lys Arg Lys Ser Asn Phe Ser Asn 
                85                  90                  95      


Ser Ala Asp Asp Ile Lys Ser Lys Lys Lys Arg Glu Gln Ser Asn Asp 
            100                 105                 110         


Thr Gly Ser Thr Gly Ser Thr Gly Ser Thr Gly Ser Thr Gly Ser His 
        115                 120                 125             


Met Ile Thr Ser Ala Leu His Arg Ala Ala Asp Trp Ala Lys Ser Val 
    130                 135                 140                 


Phe Ser Ser Ala Ala Leu Gly Asp Pro Arg Arg Thr Ala Arg Leu Val 
145                 150                 155                 160 


Asn Val Ala Ala Gln Leu Ala Lys Tyr Ser Gly Lys Ser Ile Thr Ile 
                165                 170                 175     


Ser Ser Glu Gly Ser Lys Ala Met Gln Glu Gly Ala Tyr Arg Phe Ile 
            180                 185                 190         


Arg Asn Pro Asn Val Ser Ala Glu Ala Ile Arg Lys Ala Gly Ala Met 
        195                 200                 205             


Gln Thr Val Lys Leu Ala Gln Glu Phe Pro Glu Leu Leu Ala Ile Glu 
    210                 215                 220                 


Asp Thr Thr Ser Leu Ser Tyr Arg His Gln Val Ala Glu Glu Leu Gly 
225                 230                 235                 240 


Lys Leu Gly Ser Ile Gln Asp Lys Ser Arg Gly Trp Trp Val His Ser 
                245                 250                 255     


Val Leu Leu Leu Glu Ala Thr Thr Phe Arg Thr Val Gly Leu Leu His 
            260                 265                 270         


Gln Glu Trp Trp Met Arg Pro Asp Asp Pro Ala Asp Ala Asp Glu Lys 
        275                 280                 285             


Glu Ser Gly Lys Trp Leu Ala Ala Ala Ala Thr Ser Arg Leu Arg Met 
    290                 295                 300                 


Gly Ser Met Met Ser Asn Val Ile Ala Val Cys Asp Arg Glu Ala Asp 
305                 310                 315                 320 


Ile His Ala Tyr Leu Gln Asp Lys Leu Ala His Asn Glu Arg Phe Val 
                325                 330                 335     


Val Arg Ser Lys His Pro Arg Lys Asp Val Glu Ser Gly Leu Tyr Leu 
            340                 345                 350         


Tyr Asp His Leu Lys Asn Gln Pro Glu Leu Gly Gly Tyr Gln Ile Ser 
        355                 360                 365             


Ile Pro Gln Lys Gly Val Val Asp Lys Arg Gly Lys Arg Lys Asn Arg 
    370                 375                 380                 


Pro Ala Arg Lys Ala Ser Leu Ser Leu Arg Ser Gly Arg Ile Thr Leu 
385                 390                 395                 400 


Lys Gln Gly Asn Ile Thr Leu Asn Ala Val Leu Ala Glu Glu Ile Asn 
                405                 410                 415     


Pro Pro Lys Gly Glu Thr Pro Leu Lys Trp Leu Leu Leu Thr Ser Glu 
            420                 425                 430         


Pro Val Glu Ser Leu Ala Gln Ala Leu Arg Val Ile Asp Ile Tyr Thr 
        435                 440                 445             


His Arg Trp Arg Ile Glu Glu Phe His Lys Ala Trp Lys Thr Gly Ala 
    450                 455                 460                 


Gly Ala Glu Arg Gln Arg Met Glu Glu Pro Asp Asn Leu Glu Arg Met 
465                 470                 475                 480 


Val Ser Ile Leu Ser Phe Val Ala Val Arg Leu Leu Gln Leu Arg Glu 
                485                 490                 495     


Ser Phe Thr Pro Pro Gln Ala Leu Arg Ala Gln Gly Leu Leu Lys Glu 
            500                 505                 510         


Ala Glu His Val Glu Ser Gln Ser Ala Glu Thr Val Leu Thr Pro Asp 
        515                 520                 525             


Glu Cys Gln Leu Leu Gly Tyr Leu Asp Lys Gly Lys Arg Lys Arg Lys 
    530                 535                 540                 


Glu Lys Ala Gly Ser Leu Gln Trp Ala Tyr Met Ala Ile Ala Arg Leu 
545                 550                 555                 560 


Gly Gly Phe Met Asp Ser Lys Arg Thr Gly Ile Ala Ser Trp Gly Ala 
                565                 570                 575     


Leu Trp Glu Gly Trp Glu Ala Leu Gln Ser Lys Leu Asp Gly Phe Leu 
            580                 585                 590         


Ala Ala Lys Asp Leu Met Ala Gln Gly Ile Lys Ile Cys 
        595                 600                 605 


<210>  8
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  8
atgggaaaga aaaccaagcg gacagctgac agttcttctt cagaggatga ggaggagtat       60

gttgtggaga aggtgctaga caggcgcgtg gttaagggac aagtggaata tctactgaag      120

tggaaaggct tttctgagga gcacaatact tgggaacctg agaaaaactt ggattgccct      180

gagctaattt ctgaatttat gaaaaagtat aagaagatga aggagggtga aaataataaa      240

cccagggaga agtcagaaag taacaagagg aaatccaatt tctcaaacag tgccgatgac      300

atcaaatcta aaaaaaagag agagcagagc aatgatacgg ggtcgaccgg ctcaactggt      360

tccaccgggt ccacgggctc gcatatgatt accagtgcac tgcatcgtgc ggcggattgg      420

gcgaaaagcg tgttttctag tgctgcgctg ggtgatccgc gtcgtaccgc gcgtctggtg      480

aatgttgcgg cgcaactggc caaatatagc ggcaaaagca ttaccattag cagcgaaggc      540

agcaaagcca tgcaggaagg cgcgtatcgt tttattcgta atccgaacgt gagcgcggaa      600

gcgattcgta aagcgggtgc catgcagacc gtgaaactgg cccaggaatt tccggaactg      660

ctggcaattg aagataccac ctctctgagc tatcgtcatc aggtggcgga agaactgggc      720

aaactgggta gcattcagga taaaagccgt ggttggtggg tgcatagcgt gctgctgctg      780

gaagcgacca cctttcgtac cgtgggcctg ctgcatcaag aatggtggat gcgtccggat      840

gatccggcgg atgcggatga aaaagaaagc ggcaaatggc tggccgctgc tgcaacttcg      900

cgtctgagaa tgggcagcat gatgagcaac gtgattgcgg tgtgcgatcg tgaagcggat      960

attcatgcgt atctgcaaga taaactggcc cataacgaac gttttgtggt gcgtagcaaa     1020

catccgcgta aagatgtgga aagcggcctg tatctgtatg atcacctgaa aaaccagccg     1080

gaactgggcg gctatcagat tagcattccg cagaaaggcg tggtggataa acgtggcaaa     1140

cgtaaaaacc gtccggcgcg taaagcgagc ctgagcctgc gtagcggccg tattaccctg     1200

aaacagggca acattaccct gaacgcggtg ctggccgaag aaattaatcc gccgaaaggc     1260

gaaaccccgc tgaaatggct gctgctgacc agcgagccgg tggaaagtct ggcccaagcg     1320

ctgcgtgtga ttgatattta tacccatcgt tggcgcattg aagaatttca caaagcgtgg     1380

aaaacgggtg cgggtgcgga acgtcagcgt atggaagaac cggataacct ggaacgtatg     1440

gtgagcattc tgagctttgt ggcggtgcgt ctgctgcaac tgcgtgaatc ttttactccg     1500

ccgcaagcac tgcgtgcgca gggcctgctg aaagaagcgg aacacgttga aagccagagc     1560

gcggaaaccg tgctgacccc ggatgaatgc caactgctgg gctatctgga taaaggcaaa     1620

cgcaaacgca aagaaaaagc gggcagcctg caatgggcgt atatggcgat tgcgcgtctg     1680

ggcggcttta tggatagcaa acgtaccggc attgcgagct ggggtgcgct gtgggaaggt     1740

tgggaagcgc tgcaaagcaa actggatggc tttctggccg cgaaagacct gatggcgcag     1800

ggcattaaaa tctgc                                                      1815


<210>  9
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Met Ile Thr Ser Ala Leu His Arg Ala Ala Asp Trp Ala Lys Ser Val 
1               5                   10                  15      


Phe Ser Ser Ala Ala Leu Gly Asp Pro Arg Arg Thr Ala Arg Leu Val 
            20                  25                  30          


Asn Val Ala Ala Gln Leu Ala Lys Tyr Ser Gly Lys Ser Ile Thr Ile 
        35                  40                  45              


Ser Ser Glu Gly Ser Lys Ala Met Gln Glu Gly Ala Tyr Arg Phe Ile 
    50                  55                  60                  


Arg Asn Pro Asn Val Ser Ala Glu Ala Ile Arg Lys Ala Gly Ala Met 
65                  70                  75                  80  


Gln Thr Val Lys Leu Ala Gln Glu Phe Pro Glu Leu Leu Ala Ile Glu 
                85                  90                  95      


Asp Thr Thr Ser Leu Ser Tyr Arg His Gln Val Ala Glu Glu Leu Gly 
            100                 105                 110         


Lys Leu Gly Ser Ile Gln Asp Lys Ser Arg Gly Trp Trp Val His Ser 
        115                 120                 125             


Val Leu Leu Leu Glu Ala Thr Thr Phe Arg Thr Val Gly Leu Leu His 
    130                 135                 140                 


Gln Glu Trp Trp Met Arg Pro Asp Asp Pro Ala Asp Ala Asp Glu Lys 
145                 150                 155                 160 


Glu Ser Gly Lys Trp Leu Ala Ala Ala Ala Thr Ser Arg Leu Arg Met 
                165                 170                 175     


Gly Ser Met Met Ser Asn Val Ile Ala Val Cys Asp Arg Glu Ala Asp 
            180                 185                 190         


Ile His Ala Tyr Leu Gln Asp Lys Leu Ala His Asn Glu Arg Phe Val 
        195                 200                 205             


Val Arg Ser Lys His Pro Arg Lys Asp Val Glu Ser Gly Leu Tyr Leu 
    210                 215                 220                 


Tyr Asp His Leu Lys Asn Gln Pro Glu Leu Gly Gly Tyr Gln Ile Ser 
225                 230                 235                 240 


Ile Pro Gln Lys Gly Val Val Asp Lys Arg Gly Lys Arg Lys Asn Arg 
                245                 250                 255     


Pro Ala Arg Lys Ala Ser Leu Ser Leu Arg Ser Gly Arg Ile Thr Leu 
            260                 265                 270         


Lys Gln Gly Asn Ile Thr Leu Asn Ala Val Leu Ala Glu Glu Ile Asn 
        275                 280                 285             


Pro Pro Lys Gly Glu Thr Pro Leu Lys Trp Leu Leu Leu Thr Ser Glu 
    290                 295                 300                 


Pro Val Glu Ser Leu Ala Gln Ala Leu Arg Val Ile Asp Ile Tyr Thr 
305                 310                 315                 320 


His Arg Trp Arg Ile Glu Glu Phe His Lys Ala Trp Lys Thr Gly Ala 
                325                 330                 335     


Gly Ala Glu Arg Gln Arg Met Glu Glu Pro Asp Asn Leu Glu Arg Met 
            340                 345                 350         


Val Ser Ile Leu Ser Phe Val Ala Val Arg Leu Leu Gln Leu Arg Glu 
        355                 360                 365             


Ser Phe Thr Pro Pro Gln Ala Leu Arg Ala Gln Gly Leu Leu Lys Glu 
    370                 375                 380                 


Ala Glu His Val Glu Ser Gln Ser Ala Glu Thr Val Leu Thr Pro Asp 
385                 390                 395                 400 


Glu Cys Gln Leu Leu Gly Tyr Leu Asp Lys Gly Lys Arg Lys Arg Lys 
                405                 410                 415     


Glu Lys Ala Gly Ser Leu Gln Trp Ala Tyr Met Ala Ile Ala Arg Leu 
            420                 425                 430         


Gly Gly Phe Met Asp Ser Lys Arg Thr Gly Ile Ala Ser Trp Gly Ala 
        435                 440                 445             


Leu Trp Glu Gly Trp Glu Ala Leu Gln Ser Lys Leu Asp Gly Phe Leu 
    450                 455                 460                 


Ala Ala Lys Asp Leu Met Ala Gln Gly Ile Lys Ile 
465                 470                 475     


<210>  10
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
atgattacca gtgcactgca tcgtgcggcg gattgggcga aaagcgtgtt ttctagtgct       60

gcgctgggtg atccgcgtcg taccgcgcgt ctggtgaatg ttgcggcgca actggccaaa      120

tatagcggca aaagcattac cattagcagc gaaggcagca aagccatgca ggaaggcgcg      180

tatcgtttta ttcgtaatcc gaacgtgagc gcggaagcga ttcgtaaagc gggtgccatg      240

cagaccgtga aactggccca ggaatttccg gaactgctgg caattgaaga taccacctct      300

ctgagctatc gtcatcaggt ggcggaagaa ctgggcaaac tgggtagcat tcaggataaa      360

agccgtggtt ggtgggtgca tagcgtgctg ctgctggaag cgaccacctt tcgtaccgtg      420

ggcctgctgc atcaagaatg gtggatgcgt ccggatgatc cggcggatgc ggatgaaaaa      480

gaaagcggca aatggctggc cgctgctgca acttcgcgtc tgagaatggg cagcatgatg      540

agcaacgtga ttgcggtgtg cgatcgtgaa gcggatattc atgcgtatct gcaagataaa      600

ctggcccata acgaacgttt tgtggtgcgt agcaaacatc cgcgtaaaga tgtggaaagc      660

ggcctgtatc tgtatgatca cctgaaaaac cagccggaac tgggcggcta tcagattagc      720

attccgcaga aaggcgtggt ggataaacgt ggcaaacgta aaaaccgtcc ggcgcgtaaa      780

gcgagcctga gcctgcgtag cggccgtatt accctgaaac agggcaacat taccctgaac      840

gcggtgctgg ccgaagaaat taatccgccg aaaggcgaaa ccccgctgaa atggctgctg      900

ctgaccagcg agccggtgga aagtctggcc caagcgctgc gtgtgattga tatttatacc      960

catcgttggc gcattgaaga atttcacaaa gcgtggaaaa cgggtgcggg tgcggaacgt     1020

cagcgtatgg aagaaccgga taacctggaa cgtatggtga gcattctgag ctttgtggcg     1080

gtgcgtctgc tgcaactgcg tgaatctttt actccgccgc aagcactgcg tgcgcagggc     1140

ctgctgaaag aagcggaaca cgttgaaagc cagagcgcgg aaaccgtgct gaccccggat     1200

gaatgccaac tgctgggcta tctggataaa ggcaaacgca aacgcaaaga aaaagcgggc     1260

agcctgcaat gggcgtatat ggcgattgcg cgtctgggcg gctttatgga tagcaaacgt     1320

accggcattg cgagctgggg tgcgctgtgg gaaggttggg aagcgctgca aagcaaactg     1380

gatggctttc tggccgcgaa agacctgatg gcgcagggca ttaaaatc                  1428


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Thr Gly Ser Thr Gly Ser Thr Gly Ser 
1               5                   


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Thr Gly Ser Thr Gly Ser Thr Gly Ser Thr Gly Ser 
1               5                   10          


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Thr Gly Ser Thr Gly Ser Thr Gly Ser Thr Gly Ser Thr Gly Ser 
1               5                   10                  15  


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Ser Gly Ser Gly Ser Gly Ser 
1               5           


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  20
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Met Gly Lys Lys Thr Lys Arg Thr Ala Asp Ser Ser Ser Ser Glu Asp 
1               5                   10                  15      


Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys 
            20                  25                  30          


Gly Gln Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Glu Glu His 
        35                  40                  45              


Asn Thr Trp Glu Pro Glu Lys Asn Leu Asp Cys Pro Glu Leu Ile Ser 
    50                  55                  60                  


Glu Phe Met Lys Lys Tyr Lys Lys Met Lys Glu Gly Glu Asn Asn Lys 
65                  70                  75                  80  


Pro Arg Glu Lys Ser Glu Ser Asn Lys Arg Lys Ser Asn Phe Ser Asn 
                85                  90                  95      


Ser Ala Asp Asp Ile Lys Ser Lys Lys Lys Arg Glu Gln Ser Asn Asp 
            100                 105                 110         


Ile Ala Arg Gly Phe Glu Arg Gly Leu Glu Pro Glu Lys Ile Ile Gly 
        115                 120                 125             


Ala Thr Asp Ser Cys Gly Asp Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Thr Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Val Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ala 
                165                 170                 175     


Tyr Pro Glu Asp Ala Glu Asn Lys Glu Lys Glu Thr Ala Lys Ser 
            180                 185                 190     


<210>  21
<211>  576
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
atgggaaaga aaaccaagcg gacagctgac agttcttctt cagaggatga ggaggagtat       60

gttgtggaga aggtgctaga caggcgcgtg gttaagggac aagtggaata tctactgaag      120

tggaaaggct tttctgagga gcacaatact tgggaacctg agaaaaactt ggattgccct      180

gagctaattt ctgaatttat gaaaaagtat aagaagatga aggagggtga aaataataaa      240

cccagggaga agtcagaaag taacaagagg aaatccaatt tctcaaacag tgccgatgac      300

atcaaatcta aaaaaaagag agagcagagc aatgatatcg ctcggggctt tgagagagga      360

ctggaaccag aaaagatcat tggggcaaca gattcctgtg gtgatttaat gttcctaatg      420

aaatggaaag acacagatga agctgacctg gttcttgcaa aagaagctaa tgtgaaatgt      480

ccacaaattg tgatagcatt ttatgaagag agactgacat ggcatgcata tcctgaggat      540

gcggaaaaca aagagaaaga aacagcaaag agctaa                                576


<210>  22
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Met Gly Lys Lys Thr Lys Arg Thr Ala Asp Ser Ser Ser Ser Glu Asp 
1               5                   10                  15      


Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys 
            20                  25                  30          


Gly Gln Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Glu Glu His 
        35                  40                  45              


Asn Thr Trp Glu Pro Glu Lys Asn Leu Asp Cys Pro Glu Leu Ile Ser 
    50                  55                  60                  


Glu Phe Met Lys Lys Tyr Lys Lys Met Lys Glu Gly Glu Asn Asn Lys 
65                  70                  75                  80  


Pro Arg Glu Lys Ser Glu Ser Asn Lys Arg Lys Ser Asn Phe Ser Asn 
                85                  90                  95      


Ser Ala Asp Asp Ile Lys Ser Lys Lys Lys Arg Glu Gln Ser Asn Asp 
            100                 105                 110         


<210>  23
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
atgggaaaga aaaccaagcg gacagctgac agttcttctt cagaggatga ggaggagtat       60

gttgtggaga aggtgctaga caggcgcgtg gttaagggac aagtggaata tctactgaag      120

tggaaaggct tttctgagga gcacaatact tgggaacctg agaaaaactt ggattgccct      180

gagctaattt ctgaatttat gaaaaagtat aagaagatga aggagggtga aaataataaa      240

cccagggaga agtcagaaag taacaagagg aaatccaatt tctcaaacag tgccgatgac      300

atcaaatcta aaaaaaagag agagcagagc aatgat                                336


<210>  24
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Met Gly Lys Lys Thr Lys Arg Thr Ala Asp Ser Ser Ser Ser Glu Asp 
1               5                   10                  15      


Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys 
            20                  25                  30          


Gly Gln Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Glu Glu His 
        35                  40                  45              


Asn Thr Trp Glu Pro Glu Lys Asn Leu Asp Cys Pro Glu Leu Ile Ser 
    50                  55                  60                  


Glu Phe Met Lys Lys Tyr Lys Lys Met Lys Glu Gly Glu Asn Asn Lys 
65                  70                  75                  80  


Pro Arg Glu Lys Ser Glu Ser Asn Lys Arg Lys Ser Asn 
                85                  90              


<210>  25
<211>  279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
atgggaaaga aaaccaagcg gacagctgac agttcttctt cagaggatga ggaggagtat       60

gttgtggaga aggtgctaga caggcgcgtg gttaagggac aagtggaata tctactgaag      120

tggaaaggct tttctgagga gcacaatact tgggaacctg agaaaaactt ggattgccct      180

gagctaattt ctgaatttat gaaaaagtat aagaagatga aggagggtga aaataataaa      240

cccagggaga agtcagaaag taacaagagg aaatccaat                             279


<210>  26
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
agatgtgtat aagagacag                                                    19


<210>  27
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
tcgtcggcag cgtctccgat ctcgtactag agatgtgtat aagagacag                   49


<210>  28
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
tcgtcggcag cgtctccgat cttcctgagc agatgtgtat aagagacag                   49


<210>  29
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
tcgtcggcag cgtctccgat cttcatgagc agatgtgtat aagagacag                   49


<210>  30
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
tcgtcggcag cgtctccgat ctcctgagat agatgtgtat aagagacag                   49


<210>  31
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  31
tcgtcggcag cgtctccgat cttaaggcga agatgtgtat aagagacag                   49


<210>  32
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
tcgtcggcag cgtctccgat ctgctacgct agatgtgtat aagagacag                   49


<210>  33
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  33
tcgtcggcag cgtctccgat ctaggctccg agatgtgtat aagagacag                   49


<210>  34
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
tcgtcggcag cgtctccgat ctctgcgcat agatgtgtat aagagacag                   49


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  35
gcgccttcct tacttccatg                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
agtggccatc tcatttccca                                                   20


<210>  37
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  37
aaaggccttg gtcccaga                                                     18


<210>  38
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  38
attgaaggaa cgcagccc                                                     18


<210>  39
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  39
gagggaggag aaagccga                                                     18


<210>  40
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  40
ttgtccagac cagccctt                                                     18


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  41
tcgtcggcag cgtctccgat ct                                                22


<210>  42
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  42
ccgggcagtg taacacacgt ccattctcga gaatggacgt gtgttacact gctttt           56


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
agatatatat aaggagacag                                                   20


<210>  44
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (23)..(30)
<223>  n is a, c, g, or t

<400>  44
tcgtcggcag cgtctccgat ctnnnnnnnn agatgtgtat aagagaca                    48


