                         SEQUENCE LISTING

<110>  Richter Gedeon Nyrt.
       ImmunoGenes Kft.
       Pcsi Tudomnyegyetem
       Etvs Lornd Tudomnyegyetem
 
<120>  human ACE2-Fc fusion peptides

<130>  G73266EP

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  974
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp 
            20                  25                  30          


Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala 
        35                  40                  45              


Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met 
    50                  55                  60                  


Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr 
65                  70                  75                  80  


Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys 
                85                  90                  95      


Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu 
            100                 105                 110         


Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile 
        115                 120                 125             


Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu 
    130                 135                 140                 


Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr 
145                 150                 155                 160 


Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys 
                165                 170                 175     


Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met 
            180                 185                 190         


Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp 
        195                 200                 205             


Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu 
    210                 215                 220                 


Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu 
225                 230                 235                 240 


His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser 
                245                 250                 255     


Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met 
            260                 265                 270         


Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly 
        275                 280                 285             


Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp 
    290                 295                 300                 


Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val 
305                 310                 315                 320 


Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr 
                325                 330                 335     


Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp 
            340                 345                 350         


Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met 
        355                 360                 365             


Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp 
    370                 375                 380                 


Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu 
385                 390                 395                 400 


Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr 
                405                 410                 415     


Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu 
            420                 425                 430         


Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile 
        435                 440                 445             


Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met 
    450                 455                 460                 


Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp 
465                 470                 475                 480 


Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp 
                485                 490                 495     


Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr 
            500                 505                 510         


Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln 
        515                 520                 525             


Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys 
    530                 535                 540                 


Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu 
545                 550                 555                 560 


Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val 
                565                 570                 575     


Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro 
            580                 585                 590         


Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp 
        595                 600                 605             


Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile 
    610                 615                 620                 


Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn 
625                 630                 635                 640 


Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr 
                645                 650                 655     


Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val 
            660                 665                 670         


Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr 
        675                 680                 685             


Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys 
    690                 695                 700                 


Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn 
705                 710                 715                 720 


Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro 
                725                 730                 735     


Asn Gln Pro Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            740                 745                 750         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        755                 760                 765             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    770                 775                 780                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
785                 790                 795                 800 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  2
<211>  2226
<212>  DNA
<213>  Homo Sapiens

<400>  2
atggactgga tctggcggat cctgtttctc gtgggagctg ctaccggcgc tcactcccag       60

tctacaatcg aggaacaggc caagaccttc ctggacaagt tcaaccacga ggccgaggac      120

ctgttctacc agtcctctct ggcctcctgg aactacaaca ccaacatcac cgaagagaac      180

gtgcagaaca tgaacaacgc cggcgacaag tggagcgcct tcctgaaaga gcagagcacc      240

ctggctcaga tgtaccctct gcaagagatc cagaacctga ccgtgaagct ccagctgcag      300

gccctccagc agaacggatc ttctgtgctg tccgaggaca agtccaagcg gctgaacacc      360

atcctgaata ccatgtccac catctactcc accggcaaag tgtgcaaccc tgacaaccct      420

caagagtgcc tgctgctgga acctggcctg aacgagatca tggccaacag cctggattac      480

aacgagcggc tgtgggcctg ggagtcttgg agatctgaag tgggcaagca gctgcggccc      540

ctgtacgagg aatatgtggt gctgaagaac gagatggcca gagccaacca ctacgaggac      600

tacggcgact attggagagg cgactacgaa gtgaatggcg tggacggcta cgactactcc      660

agaggccagc tgatcgagga cgtggaacac accttcgagg aaatcaagcc tctgtacgag      720

catctgcacg cctacgtgcg ggccaagctg atgaacgctt acccctccta catctcccct      780

atcggctgcc tgcctgctca tctgctggga gatatgtggg gcagattctg gaccaacctg      840

tactctctga ccgtgccttt cggccagaaa cctaacatcg acgtgaccga cgccatggtg      900

gatcaggctt gggatgccca gcggatcttc aaagaggccg agaagttctt cgtgtccgtg      960

ggcctgccta atatgaccca aggcttctgg gagaactcca tgctgaccga tcctggcaat     1020

gtgcagaaag ccgtgtgtca ccctaccgcc tgggatctcg gaaagggcga cttcagaatc     1080

ctgatgtgca ccaaagtgac catggacgac tttctgaccg ctcaccacga gatgggccac     1140

atccagtacg acatggccta cgccgctcag cccttcctgt tgagaaatgg cgccaacgag     1200

ggcttccacg aggctgtggg agagatcatg tccctgtctg ccgccacacc taagcacctg     1260

aagtctatcg gactgctgtc ccctgacttc caagaggaca acgagacaga gatcaacttc     1320

ctgctgaagc aggccctgac catcgtgggc acactgccct ttacctacat gctggaaaag     1380

tggcggtgga tggtctttaa gggcgagatc cccaaggacc agtggatgaa gaaatggtgg     1440

gagatgaagc gcgagatcgt gggcgttgtg gaacccgtgc ctcacgacga gacatactgc     1500

gaccctgcca gcctgtttca cgtgtccaac gactacagct tcatccggta ctacacccgg     1560

acactgtacc agttccagtt tcaagaggcc ctgtgccagg ccgctaagca cgaaggacct     1620

ctgcacaagt gcgacatctc caactctacc gaggccggac agaaactgtt caacatgctg     1680

cggctgggca agtccgagcc ttggacactg gctctggaaa atgtcgtggg cgccaagaat     1740

atgaacgtgc ggcctctgct gaactacttc gagcccctgt tcacctggct gaaggaccag     1800

aacaagaact ccttcgtcgg ctggtccacc gactggtccc catacgctga ccagtccatc     1860

aaagtgcgga tctccctgaa gtccgctctg ggcgataagg cctacgagtg gaacgataac     1920

gagatgtacc tgttccggtc ctccgtggct tacgctatgc ggcagtactt tctgaaagtc     1980

aagaaccaga tgatcctgtt cggcgaagag gatgtgcgcg tggccaacct gaagcctcgg     2040

atctccttca acttcttcgt gaccgctcct aagaacgtgt ccgacatcat ccctcggacc     2100

gaggtggaaa aggccatcag aatgtctcgg tcccggatca acgacgcctt ccggctgaac     2160

gacaactccc tggaatttct gggaatccag cctactctgg gccctcctaa tcagcctcct     2220

gtgtct                                                                2226


<210>  3
<211>  974
<212>  PRT
<213>  Homo Sapiens

<400>  3

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp 
            20                  25                  30          


Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala 
        35                  40                  45              


Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met 
    50                  55                  60                  


Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr 
65                  70                  75                  80  


Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys 
                85                  90                  95      


Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu 
            100                 105                 110         


Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile 
        115                 120                 125             


Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu 
    130                 135                 140                 


Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr 
145                 150                 155                 160 


Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys 
                165                 170                 175     


Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met 
            180                 185                 190         


Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp 
        195                 200                 205             


Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu 
    210                 215                 220                 


Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu 
225                 230                 235                 240 


His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser 
                245                 250                 255     


Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met 
            260                 265                 270         


Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly 
        275                 280                 285             


Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp 
    290                 295                 300                 


Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val 
305                 310                 315                 320 


Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr 
                325                 330                 335     


Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp 
            340                 345                 350         


Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met 
        355                 360                 365             


Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp 
    370                 375                 380                 


Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu 
385                 390                 395                 400 


Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr 
                405                 410                 415     


Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu 
            420                 425                 430         


Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile 
        435                 440                 445             


Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met 
    450                 455                 460                 


Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp 
465                 470                 475                 480 


Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp 
                485                 490                 495     


Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr 
            500                 505                 510         


Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln 
        515                 520                 525             


Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys 
    530                 535                 540                 


Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu 
545                 550                 555                 560 


Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val 
                565                 570                 575     


Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro 
            580                 585                 590         


Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp 
        595                 600                 605             


Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile 
    610                 615                 620                 


Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn 
625                 630                 635                 640 


Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr 
                645                 650                 655     


Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val 
            660                 665                 670         


Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr 
        675                 680                 685             


Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys 
    690                 695                 700                 


Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn 
705                 710                 715                 720 


Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro 
                725                 730                 735     


Asn Gln Pro Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            740                 745                 750         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        755                 760                 765             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    770                 775                 780                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
785                 790                 795                 800 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  4
<211>  2928
<212>  DNA
<213>  Homo Sapiens

<400>  4
atggactgga tctggcggat cctgtttctc gtgggagctg ctaccggcgc tcactcccag       60

tctacaatcg aggaacaggc caagaccttc ctggacaagt tcaaccacga ggccgaggac      120

ctgttctacc agtcctctct ggcctcctgg aactacaaca ccaacatcac cgaagagaac      180

gtgcagaaca tgaacaacgc cggcgacaag tggagcgcct tcctgaaaga gcagagcacc      240

ctggctcaga tgtaccctct gcaagagatc cagaacctga ccgtgaagct ccagctgcag      300

gccctccagc agaacggatc ttctgtgctg tccgaggaca agtccaagcg gctgaacacc      360

atcctgaata ccatgtccac catctactcc accggcaaag tgtgcaaccc tgacaaccct      420

caagagtgcc tgctgctgga acctggcctg aacgagatca tggccaacag cctggattac      480

aacgagcggc tgtgggcctg ggagtcttgg agatctgaag tgggcaagca gctgcggccc      540

ctgtacgagg aatatgtggt gctgaagaac gagatggcca gagccaacca ctacgaggac      600

tacggcgact attggagagg cgactacgaa gtgaatggcg tggacggcta cgactactcc      660

agaggccagc tgatcgagga cgtggaacac accttcgagg aaatcaagcc tctgtacgag      720

catctgcacg cctacgtgcg ggccaagctg atgaacgctt acccctccta catctcccct      780

atcggctgcc tgcctgctca tctgctggga gatatgtggg gcagattctg gaccaacctg      840

tactctctga ccgtgccttt cggccagaaa cctaacatcg acgtgaccga cgccatggtg      900

gatcaggctt gggatgccca gcggatcttc aaagaggccg agaagttctt cgtgtccgtg      960

ggcctgccta atatgaccca aggcttctgg gagaactcca tgctgaccga tcctggcaat     1020

gtgcagaaag ccgtgtgtca ccctaccgcc tgggatctcg gaaagggcga cttcagaatc     1080

ctgatgtgca ccaaagtgac catggacgac tttctgaccg ctcaccacga gatgggccac     1140

atccagtacg acatggccta cgccgctcag cccttcctgt tgagaaatgg cgccaacgag     1200

ggcttccacg aggctgtggg agagatcatg tccctgtctg ccgccacacc taagcacctg     1260

aagtctatcg gactgctgtc ccctgacttc caagaggaca acgagacaga gatcaacttc     1320

ctgctgaagc aggccctgac catcgtgggc acactgccct ttacctacat gctggaaaag     1380

tggcggtgga tggtctttaa gggcgagatc cccaaggacc agtggatgaa gaaatggtgg     1440

gagatgaagc gcgagatcgt gggcgttgtg gaacccgtgc ctcacgacga gacatactgc     1500

gaccctgcca gcctgtttca cgtgtccaac gactacagct tcatccggta ctacacccgg     1560

acactgtacc agttccagtt tcaagaggcc ctgtgccagg ccgctaagca cgaaggacct     1620

ctgcacaagt gcgacatctc caactctacc gaggccggac agaaactgtt caacatgctg     1680

cggctgggca agtccgagcc ttggacactg gctctggaaa atgtcgtggg cgccaagaat     1740

atgaacgtgc ggcctctgct gaactacttc gagcccctgt tcacctggct gaaggaccag     1800

aacaagaact ccttcgtcgg ctggtccacc gactggtccc catacgctga ccagtccatc     1860

aaagtgcgga tctccctgaa gtccgctctg ggcgataagg cctacgagtg gaacgataac     1920

gagatgtacc tgttccggtc ctccgtggct tacgctatgc ggcagtactt tctgaaagtc     1980

aagaaccaga tgatcctgtt cggcgaagag gatgtgcgcg tggccaacct gaagcctcgg     2040

atctccttca acttcttcgt gaccgctcct aagaacgtgt ccgacatcat ccctcggacc     2100

gaggtggaaa aggccatcag aatgtctcgg tcccggatca acgacgcctt ccggctgaac     2160

gacaactccc tggaatttct gggaatccag cctactctgg gccctcctaa tcagcctcct     2220

gtgtctgagc ctaagtcctg cgacaagacc cacacctgtc ctccatgtcc tgctccagaa     2280

ctgctcggcg gaccttccgt gttcctgttt cctccaaagc ctaaggacac cctgatgatc     2340

agcagaaccc ctgaagtgac ctgcgtggtg gtggatgtgt cccacgagga tcccgaagtg     2400

aagttcaatt ggtacgtcga cggcgtggaa gtgcacaacg ccaagaccaa gcctagagag     2460

gaacagtacg gctccaccta cagagtggtg tccgtgctga cagtgctgca ccaggattgg     2520

ctgaacggca aagagtacaa gtgcaaggtg tccaacaagg ctctgcccgc tcctatcgag     2580

aaaaccatct ccaaggccaa gggccagcct cgggaacctc aggtttacac cttgcctcca     2640

tctcgggacg agctgaccaa gaatcaggtg tccctgacct gcctggtcaa gggcttctac     2700

ccttccgata tcgccgtgga atgggagagc aatggccagc ctgagaacaa ctacaagaca     2760

acccctcctg tgctggactc cgacggctca ttcttcctgt acagcaagct gaccgtggac     2820

aagagccgat ggcagcaggg caacgtgttc tcctgctctg tgatgcacga ggccctgcac     2880

aatcactaca cccagaaatc cctgagcctg tctcctggca agtgatga                  2928


<210>  5
<211>  974
<212>  PRT
<213>  Homo Sapiens

<400>  5

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp 
            20                  25                  30          


Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala 
        35                  40                  45              


Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met 
    50                  55                  60                  


Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr 
65                  70                  75                  80  


Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys 
                85                  90                  95      


Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu 
            100                 105                 110         


Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile 
        115                 120                 125             


Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu 
    130                 135                 140                 


Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr 
145                 150                 155                 160 


Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys 
                165                 170                 175     


Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met 
            180                 185                 190         


Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp 
        195                 200                 205             


Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu 
    210                 215                 220                 


Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu 
225                 230                 235                 240 


His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser 
                245                 250                 255     


Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met 
            260                 265                 270         


Trp Gly Leu Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly 
        275                 280                 285             


Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp 
    290                 295                 300                 


Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val 
305                 310                 315                 320 


Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr 
                325                 330                 335     


Asp Pro Gly Asn Val Gln Lys Ala Val Cys Ala Pro Thr Ala Trp Asp 
            340                 345                 350         


Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met 
        355                 360                 365             


Asp Asp Phe Leu Phe Ala His His Glu Met Gly His Ile Gln Tyr Asp 
    370                 375                 380                 


Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu 
385                 390                 395                 400 


Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr 
                405                 410                 415     


Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu 
            420                 425                 430         


Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile 
        435                 440                 445             


Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met 
    450                 455                 460                 


Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp 
465                 470                 475                 480 


Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp 
                485                 490                 495     


Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe Leu Val Ser Asn Asp Tyr 
            500                 505                 510         


Ser Phe Thr Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln 
        515                 520                 525             


Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys 
    530                 535                 540                 


Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu 
545                 550                 555                 560 


Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val 
                565                 570                 575     


Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro 
            580                 585                 590         


Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp 
        595                 600                 605             


Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile 
    610                 615                 620                 


Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn 
625                 630                 635                 640 


Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr 
                645                 650                 655     


Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val 
            660                 665                 670         


Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr 
        675                 680                 685             


Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys 
    690                 695                 700                 


Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn 
705                 710                 715                 720 


Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro 
                725                 730                 735     


Asn Gln Pro Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            740                 745                 750         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        755                 760                 765             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    770                 775                 780                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
785                 790                 795                 800 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  6
<211>  2928
<212>  DNA
<213>  Homo Sapiens

<400>  6
atggactgga tctggcggat cctgtttctc gtgggagctg ctaccggcgc tcactcccag       60

tctacaatcg aggaacaggc caagaccttc ctggacaagt tcaaccacga ggccgaggac      120

ctgttctacc agtcctctct ggcctcctgg aactacaaca ccaacatcac cgaagagaac      180

gtgcagaaca tgaacaacgc cggcgacaag tggagcgcct tcctgaaaga gcagagcacc      240

ctggctcaga tgtaccctct gcaagagatc cagaacctga ccgtgaagct ccagctgcag      300

gccctccagc agaacggatc ttctgtgctg tccgaggaca agtccaagcg gctgaacacc      360

atcctgaata ccatgtccac catctactcc accggcaaag tgtgcaaccc tgacaaccct      420

caagagtgcc tgctgctgga acctggcctg aacgagatca tggccaacag cctggattac      480

aacgagcggc tgtgggcctg ggagtcttgg agatctgaag tgggcaagca gctgcggccc      540

ctgtacgagg aatatgtggt gctgaagaac gagatggcca gagccaacca ctacgaggac      600

tacggcgact attggagagg cgactacgaa gtgaatggcg tggacggcta cgactactcc      660

agaggccagc tgatcgagga cgtggaacac accttcgagg aaatcaagcc tctgtacgag      720

catctgcacg cctacgtgcg ggccaagctg atgaacgctt acccctccta catctcccct      780

atcggctgcc tgcctgctca tctgctggga gatatgtggg gcctgttctg gaccaacctg      840

tactctctga ccgtgccttt cggccagaaa cctaacatcg acgtgaccga cgccatggtg      900

gatcaggctt gggatgccca gcggatcttc aaagaggccg agaagttctt cgtgtccgtg      960

ggcctgccta atatgaccca aggcttctgg gagaactcca tgctgaccga tcctggcaat     1020

gtgcagaaag ccgtgtgtgc ccctaccgct tgggatctcg gaaagggcga cttccggatc     1080

ctgatgtgca ccaaagtgac catggacgac tttctgttcg cccaccacga gatgggccac     1140

atccagtacg atatggccta cgccgctcag cctttcctgc tgagaaatgg cgccaacgag     1200

ggcttccatg aggccgtggg agagatcatg tccctgtctg ctgctacccc taagcacctg     1260

aagtccatcg gactgctgag ccccgacttc caagaggaca acgagacaga gatcaacttc     1320

ctgctcaagc aggccctgac catcgtgggc acactgccct ttacctacat gctggaaaag     1380

tggcggtgga tggtctttaa gggcgagatc cccaaggacc agtggatgaa gaaatggtgg     1440

gagatgaagc gcgagatcgt gggcgttgtg gaacccgtgc ctcacgacga gacatactgc     1500

gaccctgcca gcctgtttct ggtgtccaac gactacagct tcacccggta ctacacccgg     1560

acactgtacc agttccagtt tcaagaggct ctgtgccagg ccgccaagca cgaaggacct     1620

ctgcacaagt gcgacatctc caactctacc gaggccggac agaaactgtt caacatgctg     1680

cggctgggca agtccgagcc ttggacactg gctctggaaa atgtcgtggg cgccaagaat     1740

atgaacgtgc ggcctctgct gaactacttc gagcccctgt tcacctggct gaaggaccag     1800

aacaagaact ccttcgtcgg ctggtccacc gactggtccc catacgctga ccagtccatc     1860

aaagtgcgga tctccctgaa gtctgccctg ggcgataagg cttacgagtg gaacgataac     1920

gagatgtacc tgttccggtc ctccgtggct tacgctatgc ggcagtactt tctgaaagtc     1980

aagaaccaga tgatcctgtt cggcgaagag gatgtgcgcg tggccaacct gaagcctcgg     2040

atctccttca acttcttcgt gaccgctcct aagaacgtgt ccgacatcat ccctcggacc     2100

gaggtggaaa aggccatcag aatgtctcgg tcccggatca acgacgcctt ccggctgaac     2160

gacaactccc tggaatttct gggaatccag cctactctgg gccctcctaa tcagcctcct     2220

gtgtctgagc ctaagtcctg cgacaagacc cacacctgtc ctccatgtcc tgctccagaa     2280

ctgctcggcg gaccttccgt gttcctgttt cctccaaagc ctaaggacac cctgatgatc     2340

agcagaaccc ctgaagtgac ctgcgtggtg gtggatgtgt cccacgagga tcccgaagtg     2400

aagttcaatt ggtacgtcga cggcgtggaa gtgcacaacg ccaagaccaa gcctagagag     2460

gaacagtacg gctccaccta cagagtggtg tccgtgctga cagtgctgca ccaggattgg     2520

ctgaacggca aagagtacaa gtgcaaggtt tccaacaagg ctctgcccgc tcctatcgag     2580

aaaaccatct ccaaggccaa gggccagcct cgggaacctc aggtttacac cttgcctcca     2640

tctcgggacg agctgaccaa gaatcaggtg tccctgacct gcctggtcaa gggcttctac     2700

ccttccgata tcgccgtgga atgggagagc aatggccagc ctgagaacaa ctacaagaca     2760

acccctcctg tgctggactc cgacggctca ttcttcctgt acagcaagct gaccgtggac     2820

aagagccgat ggcagcaggg caacgtgttc tcctgctctg tgatgcacga ggccctgcac     2880

aatcactaca cccagaaatc cctgtctctg tcccctggca agtgatga                  2928


<210>  7
<211>  974
<212>  PRT
<213>  Homo Sapiens

<400>  7

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp 
            20                  25                  30          


Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala 
        35                  40                  45              


Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met 
    50                  55                  60                  


Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr 
65                  70                  75                  80  


Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys 
                85                  90                  95      


Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu 
            100                 105                 110         


Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile 
        115                 120                 125             


Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu 
    130                 135                 140                 


Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr 
145                 150                 155                 160 


Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys 
                165                 170                 175     


Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met 
            180                 185                 190         


Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp 
        195                 200                 205             


Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu 
    210                 215                 220                 


Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu 
225                 230                 235                 240 


His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser 
                245                 250                 255     


Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met 
            260                 265                 270         


Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly 
        275                 280                 285             


Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp 
    290                 295                 300                 


Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val 
305                 310                 315                 320 


Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr 
                325                 330                 335     


Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp 
            340                 345                 350         


Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met 
        355                 360                 365             


Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp 
    370                 375                 380                 


Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu 
385                 390                 395                 400 


Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr 
                405                 410                 415     


Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu 
            420                 425                 430         


Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile 
        435                 440                 445             


Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met 
    450                 455                 460                 


Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp 
465                 470                 475                 480 


Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp 
                485                 490                 495     


Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr 
            500                 505                 510         


Ser Phe Thr Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln 
        515                 520                 525             


Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys 
    530                 535                 540                 


Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu 
545                 550                 555                 560 


Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val 
                565                 570                 575     


Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro 
            580                 585                 590         


Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp 
        595                 600                 605             


Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile 
    610                 615                 620                 


Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn 
625                 630                 635                 640 


Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr 
                645                 650                 655     


Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val 
            660                 665                 670         


Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr 
        675                 680                 685             


Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys 
    690                 695                 700                 


Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn 
705                 710                 715                 720 


Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro 
                725                 730                 735     


Asn Gln Pro Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            740                 745                 750         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        755                 760                 765             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    770                 775                 780                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
785                 790                 795                 800 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  8
<211>  2928
<212>  DNA
<213>  Homo Sapiens

<400>  8
atggactgga tctggcggat cctgtttctc gtgggagctg ctaccggcgc tcactcccag       60

tctacaatcg aggaacaggc caagaccttc ctggacaagt tcaaccacga ggccgaggac      120

ctgttctacc agtcctctct ggcctcctgg aactacaaca ccaacatcac cgaagagaac      180

gtgcagaaca tgaacaacgc cggcgacaag tggagcgcct tcctgaaaga gcagagcacc      240

ctggctcaga tgtaccctct gcaagagatc cagaacctga ccgtgaagct ccagctgcag      300

gccctccagc agaacggatc ttctgtgctg tccgaggaca agtccaagcg gctgaacacc      360

atcctgaata ccatgtccac catctactcc accggcaaag tgtgcaaccc tgacaaccct      420

caagagtgcc tgctgctgga acctggcctg aacgagatca tggccaacag cctggattac      480

aacgagcggc tgtgggcctg ggagtcttgg agatctgaag tgggcaagca gctgcggccc      540

ctgtacgagg aatatgtggt gctgaagaac gagatggcca gagccaacca ctacgaggac      600

tacggcgact attggagagg cgactacgaa gtgaatggcg tggacggcta cgactactcc      660

agaggccagc tgatcgagga cgtggaacac accttcgagg aaatcaagcc tctgtacgag      720

catctgcacg cctacgtgcg ggccaagctg atgaacgctt acccctccta catctcccct      780

atcggctgcc tgcctgctca tctgctggga gatatgtggg gcagattctg gaccaacctg      840

tactctctga ccgtgccttt cggccagaaa cctaacatcg acgtgaccga cgccatggtg      900

gatcaggctt gggatgccca gcggatcttc aaagaggccg agaagttctt cgtgtccgtg      960

ggcctgccta atatgaccca aggcttctgg gagaactcca tgctgaccga tcctggcaat     1020

gtgcagaaag ccgtgtgtca ccctaccgcc tgggatctcg gaaagggcga cttcagaatc     1080

ctgatgtgca ccaaagtgac catggacgac tttctgaccg ctcaccacga gatgggccac     1140

atccagtacg acatggccta cgccgctcag cccttcctgt tgagaaatgg cgccaacgag     1200

ggcttccacg aggctgtggg agagatcatg tccctgtctg ccgccacacc taagcacctg     1260

aagtctatcg gactgctgtc ccctgacttc caagaggaca acgagacaga gatcaacttc     1320

ctgctgaagc aggccctgac catcgtgggc acactgccct ttacctacat gctggaaaag     1380

tggcggtgga tggtctttaa gggcgagatc cccaaggacc agtggatgaa gaaatggtgg     1440

gagatgaagc gcgagatcgt gggcgttgtg gaacccgtgc ctcacgacga gacatactgc     1500

gaccctgcca gcctgtttca cgtgtccaac gactacagct tcacccggta ctacacccgg     1560

acactgtacc agttccagtt tcaagaggcc ctgtgccagg ccgctaagca cgaaggacct     1620

ctgcacaagt gcgacatctc caactctacc gaggccggac agaaactgtt caacatgctg     1680

cggctgggca agtccgagcc ttggacactg gctctggaaa atgtcgtggg cgccaagaat     1740

atgaacgtgc ggcctctgct gaactacttc gagcccctgt tcacctggct gaaggaccag     1800

aacaagaact ccttcgtcgg ctggtccacc gactggtccc catacgctga ccagtccatc     1860

aaagtgcgga tctccctgaa gtccgctctg ggcgataagg cctacgagtg gaacgataac     1920

gagatgtacc tgttccggtc ctccgtggct tacgctatgc ggcagtactt tctgaaagtc     1980

aagaaccaga tgatcctgtt cggcgaagag gatgtgcgcg tggccaacct gaagcctcgg     2040

atctccttca acttcttcgt gaccgctcct aagaacgtgt ccgacatcat ccctcggacc     2100

gaggtggaaa aggccatcag aatgtctcgg tcccggatca acgacgcctt ccggctgaac     2160

gacaactccc tggaatttct gggaatccag cctactctgg gccctcctaa tcagcctcct     2220

gtgtctgagc ctaagtcctg cgacaagacc cacacctgtc ctccatgtcc tgctccagaa     2280

ctgctcggcg gaccttccgt gttcctgttt cctccaaagc ctaaggacac cctgatgatc     2340

agcagaaccc ctgaagtgac ctgcgtggtg gtggatgtgt cccacgagga tcccgaagtg     2400

aagttcaatt ggtacgtcga cggcgtggaa gtgcacaacg ccaagaccaa gcctagagag     2460

gaacagtacg gctccaccta cagagtggtg tccgtgctga cagtgctgca ccaggattgg     2520

ctgaacggca aagagtacaa gtgcaaggtg tccaacaagg ctctgcccgc tcctatcgag     2580

aaaaccatct ccaaggccaa gggccagcct cgggaacctc aggtttacac cttgcctcca     2640

tctcgggacg agctgaccaa gaatcaggtg tccctgacct gcctggtcaa gggcttctac     2700

ccttccgata tcgccgtgga atgggagagc aatggccagc ctgagaacaa ctacaagaca     2760

acccctcctg tgctggactc cgacggctca ttcttcctgt acagcaagct gaccgtggac     2820

aagagccgat ggcagcaggg caacgtgttc tcctgctctg tgatgcacga ggccctgcac     2880

aatcactaca cccagaaatc cctgagcctg tctcctggca agtgatga                  2928


<210>  9
<211>  974
<212>  PRT
<213>  Homo Sapiens

<400>  9

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp 
            20                  25                  30          


Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala 
        35                  40                  45              


Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met 
    50                  55                  60                  


Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr 
65                  70                  75                  80  


Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys 
                85                  90                  95      


Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu 
            100                 105                 110         


Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile 
        115                 120                 125             


Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu 
    130                 135                 140                 


Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr 
145                 150                 155                 160 


Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys 
                165                 170                 175     


Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met 
            180                 185                 190         


Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp 
        195                 200                 205             


Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu 
    210                 215                 220                 


Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu 
225                 230                 235                 240 


His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser 
                245                 250                 255     


Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met 
            260                 265                 270         


Trp Gly Leu Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly 
        275                 280                 285             


Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp 
    290                 295                 300                 


Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val 
305                 310                 315                 320 


Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr 
                325                 330                 335     


Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp 
            340                 345                 350         


Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met 
        355                 360                 365             


Asp Asp Phe Leu Phe Ala His His Glu Met Gly His Ile Gln Tyr Asp 
    370                 375                 380                 


Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu 
385                 390                 395                 400 


Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr 
                405                 410                 415     


Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu 
            420                 425                 430         


Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile 
        435                 440                 445             


Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met 
    450                 455                 460                 


Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp 
465                 470                 475                 480 


Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp 
                485                 490                 495     


Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe Leu Val Ser Asn Asp Tyr 
            500                 505                 510         


Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln 
        515                 520                 525             


Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys 
    530                 535                 540                 


Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu 
545                 550                 555                 560 


Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val 
                565                 570                 575     


Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro 
            580                 585                 590         


Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp 
        595                 600                 605             


Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile 
    610                 615                 620                 


Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn 
625                 630                 635                 640 


Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr 
                645                 650                 655     


Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val 
            660                 665                 670         


Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr 
        675                 680                 685             


Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys 
    690                 695                 700                 


Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn 
705                 710                 715                 720 


Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro 
                725                 730                 735     


Asn Gln Pro Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            740                 745                 750         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        755                 760                 765             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    770                 775                 780                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
785                 790                 795                 800 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  10
<211>  2928
<212>  DNA
<213>  Homo Sapiens

<400>  10
atggactgga tctggcggat cctgtttctc gtgggagctg ctaccggcgc tcactcccag       60

tctacaatcg aggaacaggc caagaccttc ctggacaagt tcaaccacga ggccgaggac      120

ctgttctacc agtcctctct ggcctcctgg aactacaaca ccaacatcac cgaagagaac      180

gtgcagaaca tgaacaacgc cggcgacaag tggagcgcct tcctgaaaga gcagagcacc      240

ctggctcaga tgtaccctct gcaagagatc cagaacctga ccgtgaagct ccagctgcag      300

gccctccagc agaacggatc ttctgtgctg tccgaggaca agtccaagcg gctgaacacc      360

atcctgaata ccatgtccac catctactcc accggcaaag tgtgcaaccc tgacaaccct      420

caagagtgcc tgctgctgga acctggcctg aacgagatca tggccaacag cctggattac      480

aacgagcggc tgtgggcctg ggagtcttgg agatctgaag tgggcaagca gctgcggccc      540

ctgtacgagg aatatgtggt gctgaagaac gagatggcca gagccaacca ctacgaggac      600

tacggcgact attggagagg cgactacgaa gtgaatggcg tggacggcta cgactactcc      660

agaggccagc tgatcgagga cgtggaacac accttcgagg aaatcaagcc tctgtacgag      720

catctgcacg cctacgtgcg ggccaagctg atgaacgctt acccctccta catctcccct      780

atcggctgcc tgcctgctca tctgctggga gatatgtggg gcctgttctg gaccaacctg      840

tactctctga ccgtgccttt cggccagaaa cctaacatcg acgtgaccga cgccatggtg      900

gatcaggctt gggatgccca gcggatcttc aaagaggccg agaagttctt cgtgtccgtg      960

ggcctgccta atatgaccca aggcttctgg gagaactcca tgctgaccga tcctggcaat     1020

gtgcagaaag ccgtgtgtca ccctaccgcc tgggatctcg gaaagggcga cttcagaatc     1080

ctgatgtgca ccaaagtgac catggacgac tttctgttcg cccaccacga gatgggccac     1140

atccagtacg atatggccta cgccgctcag cctttcctgc tgagaaatgg cgccaacgag     1200

ggcttccatg aggccgtggg agagatcatg tccctgtctg ctgctacccc taagcacctg     1260

aagtccatcg gactgctgag ccccgacttc caagaggaca acgagacaga gatcaacttc     1320

ctgctcaagc aggccctgac catcgtgggc acactgccct ttacctacat gctggaaaag     1380

tggcggtgga tggtctttaa gggcgagatc cccaaggacc agtggatgaa gaaatggtgg     1440

gagatgaagc gcgagatcgt gggcgttgtg gaacccgtgc ctcacgacga gacatactgc     1500

gaccctgcca gcctgtttct ggtgtccaac gactacagct tcatccggta ctacacccgg     1560

acactgtacc agttccagtt tcaagaggct ctgtgccagg ccgccaagca cgaaggacct     1620

ctgcacaagt gcgacatctc caactctacc gaggccggac agaaactgtt caacatgctg     1680

cggctgggca agtccgagcc ttggacactg gctctggaaa atgtcgtggg cgccaagaat     1740

atgaacgtgc ggcctctgct gaactacttc gagcccctgt tcacctggct gaaggaccag     1800

aacaagaact ccttcgtcgg ctggtccacc gactggtccc catacgctga ccagtccatc     1860

aaagtgcgga tctccctgaa gtctgctctg ggcgacaagg cctacgagtg gaacgataac     1920

gagatgtacc tgttccggtc ctccgtggct tacgctatgc ggcagtactt tctgaaagtc     1980

aagaaccaga tgatcctgtt cggcgaagag gatgtgcgcg tggccaacct gaagcctcgg     2040

atctccttca acttcttcgt gaccgctcct aagaacgtgt ccgacatcat ccctcggacc     2100

gaggtggaaa aggccatcag aatgtctcgg tcccggatca acgacgcctt ccggctgaac     2160

gacaactccc tggaatttct gggaatccag cctactctgg gccctcctaa tcagcctcct     2220

gtgtctgagc ctaagtcctg cgacaagacc cacacctgtc ctccatgtcc tgctccagaa     2280

ctgctcggcg gaccttccgt gttcctgttt cctccaaagc ctaaggacac cctgatgatc     2340

agcagaaccc ctgaagtgac ctgcgtggtg gtggatgtgt cccacgagga tcccgaagtg     2400

aagttcaatt ggtacgtcga cggcgtggaa gtgcacaacg ccaagaccaa gcctagagag     2460

gaacagtacg gctccaccta cagagtggtg tccgtgctga cagtgctgca ccaggattgg     2520

ctgaacggca aagagtacaa gtgcaaggtt tccaacaagg ctctgcccgc tcctatcgag     2580

aaaaccatct ccaaggccaa gggccagcct cgggaacctc aggtttacac cttgcctcca     2640

tctcgggacg agctgaccaa gaatcaggtg tccctgacct gcctggtcaa gggcttctac     2700

ccttccgata tcgccgtgga atgggagagc aatggccagc ctgagaacaa ctacaagaca     2760

acccctcctg tgctggactc cgacggctca ttcttcctgt acagcaagct gaccgtggac     2820

aagagccgat ggcagcaggg caacgtgttc tcctgctctg tgatgcacga ggccctgcac     2880

aatcactaca cccagaaatc cctgtctctg tcccctggca agtgatga                  2928


<210>  11
<211>  974
<212>  PRT
<213>  Homo Sapiens

<400>  11

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp 
            20                  25                  30          


Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala 
        35                  40                  45              


Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met 
    50                  55                  60                  


Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr 
65                  70                  75                  80  


Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys 
                85                  90                  95      


Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu 
            100                 105                 110         


Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile 
        115                 120                 125             


Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu 
    130                 135                 140                 


Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr 
145                 150                 155                 160 


Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys 
                165                 170                 175     


Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met 
            180                 185                 190         


Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp 
        195                 200                 205             


Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu 
    210                 215                 220                 


Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu 
225                 230                 235                 240 


His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser 
                245                 250                 255     


Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met 
            260                 265                 270         


Trp Gly Leu Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly 
        275                 280                 285             


Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp 
    290                 295                 300                 


Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val 
305                 310                 315                 320 


Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr 
                325                 330                 335     


Asp Pro Gly Asn Val Gln Lys Ala Val Cys Ala Pro Thr Ala Trp Asp 
            340                 345                 350         


Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met 
        355                 360                 365             


Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp 
    370                 375                 380                 


Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu 
385                 390                 395                 400 


Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr 
                405                 410                 415     


Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu 
            420                 425                 430         


Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile 
        435                 440                 445             


Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met 
    450                 455                 460                 


Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp 
465                 470                 475                 480 


Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp 
                485                 490                 495     


Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe Leu Val Ser Asn Asp Tyr 
            500                 505                 510         


Ser Phe Thr Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln 
        515                 520                 525             


Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys 
    530                 535                 540                 


Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu 
545                 550                 555                 560 


Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val 
                565                 570                 575     


Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro 
            580                 585                 590         


Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp 
        595                 600                 605             


Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile 
    610                 615                 620                 


Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn 
625                 630                 635                 640 


Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr 
                645                 650                 655     


Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val 
            660                 665                 670         


Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr 
        675                 680                 685             


Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys 
    690                 695                 700                 


Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn 
705                 710                 715                 720 


Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro 
                725                 730                 735     


Asn Gln Pro Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            740                 745                 750         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        755                 760                 765             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    770                 775                 780                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
785                 790                 795                 800 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  12
<211>  2928
<212>  DNA
<213>  Homo Sapiens

<400>  12
atggactgga tctggcggat cctgtttctc gtgggagctg ctaccggcgc tcactcccag       60

tctacaatcg aggaacaggc caagaccttc ctggacaagt tcaaccacga ggccgaggac      120

ctgttctacc agtcctctct ggcctcctgg aactacaaca ccaacatcac cgaagagaac      180

gtgcagaaca tgaacaacgc cggcgacaag tggagcgcct tcctgaaaga gcagagcacc      240

ctggctcaga tgtaccctct gcaagagatc cagaacctga ccgtgaagct ccagctgcag      300

gccctccagc agaacggatc ttctgtgctg tccgaggaca agtccaagcg gctgaacacc      360

atcctgaata ccatgtccac catctactcc accggcaaag tgtgcaaccc tgacaaccct      420

caagagtgcc tgctgctgga acctggcctg aacgagatca tggccaacag cctggattac      480

aacgagcggc tgtgggcctg ggagtcttgg agatctgaag tgggcaagca gctgcggccc      540

ctgtacgagg aatatgtggt gctgaagaac gagatggcca gagccaacca ctacgaggac      600

tacggcgact attggagagg cgactacgaa gtgaatggcg tggacggcta cgactactcc      660

agaggccagc tgatcgagga cgtggaacac accttcgagg aaatcaagcc tctgtacgag      720

catctgcacg cctacgtgcg ggccaagctg atgaacgctt acccctccta catctcccct      780

atcggctgcc tgcctgctca tctgctggga gatatgtggg gcctgttctg gaccaacctg      840

tactctctga ccgtgccttt cggccagaaa cctaacatcg acgtgaccga cgccatggtg      900

gatcaggctt gggatgccca gcggatcttc aaagaggccg agaagttctt cgtgtccgtg      960

ggcctgccta atatgaccca aggcttctgg gagaactcca tgctgaccga tcctggcaat     1020

gtgcagaaag ccgtgtgtgc ccctaccgct tgggatctcg gaaagggcga cttccggatc     1080

ctgatgtgca ccaaagtgac catggacgac tttctgaccg ctcaccacga gatgggccac     1140

atccagtacg acatggccta cgccgctcag cccttcctgt tgagaaatgg cgccaacgag     1200

ggcttccacg aggctgtggg agagatcatg tccctgtctg ccgccacacc taagcacctg     1260

aagtctatcg gactgctgtc ccctgacttc caagaggaca acgagacaga gatcaacttc     1320

ctgctgaagc aggccctgac catcgtgggc acactgccct ttacctacat gctggaaaag     1380

tggcggtgga tggtctttaa gggcgagatc cccaaggacc agtggatgaa gaaatggtgg     1440

gagatgaagc gcgagatcgt gggcgttgtg gaacccgtgc ctcacgacga gacatactgc     1500

gaccctgcca gcctgtttct ggtgtccaac gactacagct tcacccggta ctacacccgg     1560

acactgtacc agttccagtt tcaagaggcc ctgtgccagg ccgctaagca cgaaggacct     1620

ctgcacaagt gcgacatctc caactctacc gaggccggac agaaactgtt caacatgctg     1680

cggctgggca agtccgagcc ttggacactg gctctggaaa atgtcgtggg cgccaagaat     1740

atgaacgtgc ggcctctgct gaactacttc gagcccctgt tcacctggct gaaggaccag     1800

aacaagaact ccttcgtcgg ctggtccacc gactggtccc catacgctga ccagtccatc     1860

aaagtgcgga tctccctgaa gtccgctctg ggcgataagg cctacgagtg gaacgataac     1920

gagatgtacc tgttccggtc ctccgtggct tacgctatgc ggcagtactt tctgaaagtc     1980

aagaaccaga tgatcctgtt cggcgaagag gatgtgcgcg tggccaacct gaagcctcgg     2040

atctccttca acttcttcgt gaccgctcct aagaacgtgt ccgacatcat ccctcggacc     2100

gaggtggaaa aggccatcag aatgtctcgg tcccggatca acgacgcctt ccggctgaac     2160

gacaactccc tggaatttct gggaatccag cctactctgg gccctcctaa tcagcctcct     2220

gtgtctgagc ctaagtcctg cgacaagacc cacacctgtc ctccatgtcc tgctccagaa     2280

ctgctcggcg gaccttccgt gttcctgttt cctccaaagc ctaaggacac cctgatgatc     2340

agcagaaccc ctgaagtgac ctgcgtggtg gtggatgtgt cccacgagga tcccgaagtg     2400

aagttcaatt ggtacgtcga cggcgtggaa gtgcacaacg ccaagaccaa gcctagagag     2460

gaacagtacg gctccaccta cagagtggtg tccgtgctga cagtgctgca ccaggattgg     2520

ctgaacggca aagagtacaa gtgcaaggtt tccaacaagg ctctgcccgc tcctatcgag     2580

aaaaccatct ccaaggccaa gggccagcct cgggaacctc aggtttacac cttgcctcca     2640

tctcgggacg agctgaccaa gaatcaggtg tccctgacct gcctggtcaa gggcttctac     2700

ccttccgata tcgccgtgga atgggagagc aatggccagc ctgagaacaa ctacaagaca     2760

acccctcctg tgctggactc cgacggctca ttcttcctgt acagcaagct gaccgtggac     2820

aagagccgat ggcagcaggg caacgtgttc tcctgctctg tgatgcacga ggccctgcac     2880

aatcactaca cccagaaatc cctgagcctg tctcctggca agtgatga                  2928


<210>  13
<211>  955
<212>  PRT
<213>  Homo sapiens

<400>  13

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Leu 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys Ala Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Phe Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe Leu Val Ser Asn Asp Tyr Ser Phe Thr 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys 
        595                 600                 605             


Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr 
    610                 615                 620                 


Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys 
625                 630                 635                 640 


Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala 
                645                 650                 655     


Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys 
            660                 665                 670         


Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg 
        675                 680                 685             


Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser 
    690                 695                 700                 


Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro 
705                 710                 715                 720 


Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                725                 730                 735     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            740                 745                 750         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        755                 760                 765             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    770                 775                 780                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
785                 790                 795                 800 


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                805                 810                 815     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            820                 825                 830         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        835                 840                 845             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    850                 855                 860                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
865                 870                 875                 880 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                885                 890                 895     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            900                 905                 910         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        915                 920                 925             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    930                 935                 940                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
945                 950                 955 


<210>  14
<211>  955
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Thr 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys 
        595                 600                 605             


Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr 
    610                 615                 620                 


Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys 
625                 630                 635                 640 


Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala 
                645                 650                 655     


Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys 
            660                 665                 670         


Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg 
        675                 680                 685             


Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser 
    690                 695                 700                 


Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro 
705                 710                 715                 720 


Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                725                 730                 735     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            740                 745                 750         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        755                 760                 765             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    770                 775                 780                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
785                 790                 795                 800 


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                805                 810                 815     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            820                 825                 830         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        835                 840                 845             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    850                 855                 860                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
865                 870                 875                 880 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                885                 890                 895     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            900                 905                 910         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        915                 920                 925             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    930                 935                 940                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
945                 950                 955 


<210>  15
<211>  955
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Leu 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Phe Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe Leu Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys 
        595                 600                 605             


Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr 
    610                 615                 620                 


Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys 
625                 630                 635                 640 


Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala 
                645                 650                 655     


Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys 
            660                 665                 670         


Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg 
        675                 680                 685             


Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser 
    690                 695                 700                 


Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro 
705                 710                 715                 720 


Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                725                 730                 735     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            740                 745                 750         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        755                 760                 765             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    770                 775                 780                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
785                 790                 795                 800 


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                805                 810                 815     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            820                 825                 830         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        835                 840                 845             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    850                 855                 860                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
865                 870                 875                 880 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                885                 890                 895     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            900                 905                 910         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        915                 920                 925             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    930                 935                 940                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
945                 950                 955 


<210>  16
<211>  955
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Leu 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys Ala Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe Leu Val Ser Asn Asp Tyr Ser Phe Thr 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys 
        595                 600                 605             


Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr 
    610                 615                 620                 


Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys 
625                 630                 635                 640 


Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala 
                645                 650                 655     


Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys 
            660                 665                 670         


Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg 
        675                 680                 685             


Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser 
    690                 695                 700                 


Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro 
705                 710                 715                 720 


Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                725                 730                 735     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            740                 745                 750         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        755                 760                 765             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    770                 775                 780                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
785                 790                 795                 800 


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                805                 810                 815     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            820                 825                 830         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        835                 840                 845             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    850                 855                 860                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
865                 870                 875                 880 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                885                 890                 895     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            900                 905                 910         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        915                 920                 925             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    930                 935                 940                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
945                 950                 955 


<210>  17
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp 
            20                  25                  30          


Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala 
        35                  40                  45              


Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met 
    50                  55                  60                  


Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr 
65                  70                  75                  80  


Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys 
                85                  90                  95      


Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu 
            100                 105                 110         


Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile 
        115                 120                 125             


Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu 
    130                 135                 140                 


Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr 
145                 150                 155                 160 


Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys 
                165                 170                 175     


Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met 
            180                 185                 190         


Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp 
        195                 200                 205             


Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu 
    210                 215                 220                 


Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu 
225                 230                 235                 240 


His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser 
                245                 250                 255     


Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met 
            260                 265                 270         


Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly 
        275                 280                 285             


Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp 
    290                 295                 300                 


Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val 
305                 310                 315                 320 


Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr 
                325                 330                 335     


Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp 
            340                 345                 350         


Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met 
        355                 360                 365             


Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp 
    370                 375                 380                 


Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu 
385                 390                 395                 400 


Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr 
                405                 410                 415     


Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu 
            420                 425                 430         


Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile 
        435                 440                 445             


Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met 
    450                 455                 460                 


Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp 
465                 470                 475                 480 


Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp 
                485                 490                 495     


Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe Leu Val Ser Asn Asp Tyr 
            500                 505                 510         


Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln 
        515                 520                 525             


Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys 
    530                 535                 540                 


Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu 
545                 550                 555                 560 


Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val 
                565                 570                 575     


Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro 
            580                 585                 590         


Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp 
        595                 600                 605             


Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile 
    610                 615                 620                 


Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn 
625                 630                 635                 640 


Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr 
                645                 650                 655     


Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val 
            660                 665                 670         


Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr 
        675                 680                 685             


Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys 
    690                 695                 700                 


Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn 
705                 710                 715                 720 


Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro 
                725                 730                 735     


Asn Gln Pro Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            740                 745                 750         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        755                 760                 765             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    770                 775                 780                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
785                 790                 795                 800 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  18
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp 
            20                  25                  30          


Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala 
        35                  40                  45              


Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met 
    50                  55                  60                  


Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr 
65                  70                  75                  80  


Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys 
                85                  90                  95      


Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu 
            100                 105                 110         


Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile 
        115                 120                 125             


Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu 
    130                 135                 140                 


Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr 
145                 150                 155                 160 


Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys 
                165                 170                 175     


Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met 
            180                 185                 190         


Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp 
        195                 200                 205             


Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu 
    210                 215                 220                 


Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu 
225                 230                 235                 240 


His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser 
                245                 250                 255     


Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met 
            260                 265                 270         


Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly 
        275                 280                 285             


Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp 
    290                 295                 300                 


Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val 
305                 310                 315                 320 


Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr 
                325                 330                 335     


Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp 
            340                 345                 350         


Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met 
        355                 360                 365             


Asp Asp Phe Leu Phe Ala His His Glu Met Gly His Ile Gln Tyr Asp 
    370                 375                 380                 


Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu 
385                 390                 395                 400 


Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr 
                405                 410                 415     


Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu 
            420                 425                 430         


Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile 
        435                 440                 445             


Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met 
    450                 455                 460                 


Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp 
465                 470                 475                 480 


Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp 
                485                 490                 495     


Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr 
            500                 505                 510         


Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln 
        515                 520                 525             


Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys 
    530                 535                 540                 


Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu 
545                 550                 555                 560 


Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val 
                565                 570                 575     


Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro 
            580                 585                 590         


Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp 
        595                 600                 605             


Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile 
    610                 615                 620                 


Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn 
625                 630                 635                 640 


Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr 
                645                 650                 655     


Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val 
            660                 665                 670         


Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr 
        675                 680                 685             


Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys 
    690                 695                 700                 


Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn 
705                 710                 715                 720 


Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro 
                725                 730                 735     


Asn Gln Pro Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            740                 745                 750         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        755                 760                 765             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    770                 775                 780                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
785                 790                 795                 800 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  19
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp 
            20                  25                  30          


Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala 
        35                  40                  45              


Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met 
    50                  55                  60                  


Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr 
65                  70                  75                  80  


Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys 
                85                  90                  95      


Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu 
            100                 105                 110         


Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile 
        115                 120                 125             


Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu 
    130                 135                 140                 


Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr 
145                 150                 155                 160 


Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys 
                165                 170                 175     


Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met 
            180                 185                 190         


Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp 
        195                 200                 205             


Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu 
    210                 215                 220                 


Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu 
225                 230                 235                 240 


His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser 
                245                 250                 255     


Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met 
            260                 265                 270         


Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly 
        275                 280                 285             


Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp 
    290                 295                 300                 


Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val 
305                 310                 315                 320 


Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr 
                325                 330                 335     


Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp 
            340                 345                 350         


Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met 
        355                 360                 365             


Asp Asp Phe Leu Phe Ala His His Glu Met Gly His Ile Gln Tyr Asp 
    370                 375                 380                 


Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu 
385                 390                 395                 400 


Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr 
                405                 410                 415     


Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu 
            420                 425                 430         


Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile 
        435                 440                 445             


Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met 
    450                 455                 460                 


Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp 
465                 470                 475                 480 


Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp 
                485                 490                 495     


Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr 
            500                 505                 510         


Ser Phe Thr Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln 
        515                 520                 525             


Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys 
    530                 535                 540                 


Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu 
545                 550                 555                 560 


Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val 
                565                 570                 575     


Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro 
            580                 585                 590         


Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp 
        595                 600                 605             


Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile 
    610                 615                 620                 


Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn 
625                 630                 635                 640 


Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr 
                645                 650                 655     


Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val 
            660                 665                 670         


Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr 
        675                 680                 685             


Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys 
    690                 695                 700                 


Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn 
705                 710                 715                 720 


Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro 
                725                 730                 735     


Asn Gln Pro Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            740                 745                 750         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        755                 760                 765             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    770                 775                 780                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
785                 790                 795                 800 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  20
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp 
            20                  25                  30          


Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala 
        35                  40                  45              


Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met 
    50                  55                  60                  


Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr 
65                  70                  75                  80  


Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys 
                85                  90                  95      


Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu 
            100                 105                 110         


Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile 
        115                 120                 125             


Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu 
    130                 135                 140                 


Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr 
145                 150                 155                 160 


Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys 
                165                 170                 175     


Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met 
            180                 185                 190         


Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp 
        195                 200                 205             


Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu 
    210                 215                 220                 


Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu 
225                 230                 235                 240 


His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser 
                245                 250                 255     


Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met 
            260                 265                 270         


Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly 
        275                 280                 285             


Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp 
    290                 295                 300                 


Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val 
305                 310                 315                 320 


Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr 
                325                 330                 335     


Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp 
            340                 345                 350         


Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met 
        355                 360                 365             


Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp 
    370                 375                 380                 


Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu 
385                 390                 395                 400 


Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr 
                405                 410                 415     


Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu 
            420                 425                 430         


Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile 
        435                 440                 445             


Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met 
    450                 455                 460                 


Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp 
465                 470                 475                 480 


Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp 
                485                 490                 495     


Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe Leu Val Ser Asn Asp Tyr 
            500                 505                 510         


Ser Phe Thr Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln 
        515                 520                 525             


Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys 
    530                 535                 540                 


Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu 
545                 550                 555                 560 


Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val 
                565                 570                 575     


Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro 
            580                 585                 590         


Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp 
        595                 600                 605             


Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile 
    610                 615                 620                 


Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn 
625                 630                 635                 640 


Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr 
                645                 650                 655     


Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val 
            660                 665                 670         


Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr 
        675                 680                 685             


Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys 
    690                 695                 700                 


Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn 
705                 710                 715                 720 


Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro 
                725                 730                 735     


Asn Gln Pro Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            740                 745                 750         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        755                 760                 765             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    770                 775                 780                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
785                 790                 795                 800 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  21
<211>  955
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe Leu Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys 
        595                 600                 605             


Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr 
    610                 615                 620                 


Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys 
625                 630                 635                 640 


Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala 
                645                 650                 655     


Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys 
            660                 665                 670         


Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg 
        675                 680                 685             


Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser 
    690                 695                 700                 


Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro 
705                 710                 715                 720 


Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                725                 730                 735     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            740                 745                 750         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        755                 760                 765             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    770                 775                 780                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
785                 790                 795                 800 


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                805                 810                 815     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            820                 825                 830         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        835                 840                 845             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    850                 855                 860                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
865                 870                 875                 880 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                885                 890                 895     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            900                 905                 910         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        915                 920                 925             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    930                 935                 940                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
945                 950                 955 


<210>  22
<211>  955
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Phe Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys 
        595                 600                 605             


Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr 
    610                 615                 620                 


Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys 
625                 630                 635                 640 


Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala 
                645                 650                 655     


Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys 
            660                 665                 670         


Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg 
        675                 680                 685             


Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser 
    690                 695                 700                 


Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro 
705                 710                 715                 720 


Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                725                 730                 735     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            740                 745                 750         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        755                 760                 765             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    770                 775                 780                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
785                 790                 795                 800 


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                805                 810                 815     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            820                 825                 830         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        835                 840                 845             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    850                 855                 860                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
865                 870                 875                 880 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                885                 890                 895     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            900                 905                 910         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        915                 920                 925             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    930                 935                 940                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
945                 950                 955 


<210>  23
<211>  955
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Phe Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Thr 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys 
        595                 600                 605             


Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr 
    610                 615                 620                 


Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys 
625                 630                 635                 640 


Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala 
                645                 650                 655     


Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys 
            660                 665                 670         


Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg 
        675                 680                 685             


Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser 
    690                 695                 700                 


Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro 
705                 710                 715                 720 


Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                725                 730                 735     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            740                 745                 750         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        755                 760                 765             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    770                 775                 780                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
785                 790                 795                 800 


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                805                 810                 815     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            820                 825                 830         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        835                 840                 845             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    850                 855                 860                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
865                 870                 875                 880 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                885                 890                 895     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            900                 905                 910         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        915                 920                 925             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    930                 935                 940                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
945                 950                 955 


<210>  24
<211>  955
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe Leu Val Ser Asn Asp Tyr Ser Phe Thr 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys 
        595                 600                 605             


Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr 
    610                 615                 620                 


Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys 
625                 630                 635                 640 


Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala 
                645                 650                 655     


Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys 
            660                 665                 670         


Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg 
        675                 680                 685             


Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser 
    690                 695                 700                 


Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro 
705                 710                 715                 720 


Pro Val Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                725                 730                 735     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            740                 745                 750         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        755                 760                 765             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    770                 775                 780                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
785                 790                 795                 800 


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                805                 810                 815     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            820                 825                 830         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        835                 840                 845             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    850                 855                 860                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
865                 870                 875                 880 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                885                 890                 895     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            900                 905                 910         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        915                 920                 925             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    930                 935                 940                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
945                 950                 955 


