                               SEQUENCE LISTING

<110> SIGILON THERAPEUTICS, INC.
 
<120> COMPOSITIONS, DEVICES AND METHODS FOR TREATING MPS VI DISEASE

<130> S2225-7041WO

<140> PCT/US2022/015316
<141> 2022-02-04

<150> 63/146,340
<151> 2021-02-05

<160> 28    

<170> PatentIn version 3.5

<210> 1
<211> 533
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Pro Arg Gly Ala Ala Ser Leu Pro Arg Gly Pro Gly Pro Arg 
1               5                   10                  15      


Arg Leu Leu Leu Pro Val Val Leu Pro Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Ala Pro Pro Gly Ser Gly Ala Gly Ala Ser Arg Pro Pro His Leu Val 
        35                  40                  45              


Phe Leu Leu Ala Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His Gly 
    50                  55                  60                  


Ser Arg Ile Arg Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly Val 
65                  70                  75                  80  


Leu Leu Asp Asn Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg Ser 
                85                  90                  95      


Gln Leu Leu Thr Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His Gln 
            100                 105                 110         


Ile Ile Trp Pro Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys Leu 
        115                 120                 125             


Leu Pro Gln Leu Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val Gly 
    130                 135                 140                 


Lys Trp His Leu Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg Arg 
145                 150                 155                 160 


Gly Phe Asp Thr Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr Tyr 
                165                 170                 175     


Ser His Glu Arg Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg Cys 
            180                 185                 190         


Ala Leu Asp Phe Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys Asn 
        195                 200                 205             


Met Tyr Ser Thr Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile Thr 
    210                 215                 220                 


Asn His Pro Pro Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln Ser 
225                 230                 235                 240 


Val His Glu Pro Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr Asp 
                245                 250                 255     


Phe Ile Gln Asp Lys Asn Arg His His Tyr Ala Gly Met Val Ser Leu 
            260                 265                 270         


Met Asp Glu Ala Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser Gly 
        275                 280                 285             


Leu Trp Asn Asn Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly Gln 
    290                 295                 300                 


Thr Leu Ala Gly Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp Ser 
305                 310                 315                 320 


Leu Trp Glu Gly Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro Leu 
                325                 330                 335     


Leu Lys Gln Lys Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser Asp 
            340                 345                 350         


Trp Leu Pro Thr Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly Thr 
        355                 360                 365             


Lys Pro Leu Asp Gly Phe Asp Val Trp Lys Thr Ile Ser Glu Gly Ser 
    370                 375                 380                 


Pro Ser Pro Arg Ile Glu Leu Leu His Asn Ile Asp Pro Asn Phe Val 
385                 390                 395                 400 


Asp Ser Ser Pro Cys Pro Arg Asn Ser Met Ala Pro Ala Lys Asp Asp 
                405                 410                 415     


Ser Ser Leu Pro Glu Tyr Ser Ala Phe Asn Thr Ser Val His Ala Ala 
            420                 425                 430         


Ile Arg His Gly Asn Trp Lys Leu Leu Thr Gly Tyr Pro Gly Cys Gly 
        435                 440                 445             


Tyr Trp Phe Pro Pro Pro Ser Gln Tyr Asn Val Ser Glu Ile Pro Ser 
    450                 455                 460                 


Ser Asp Pro Pro Thr Lys Thr Leu Trp Leu Phe Asp Ile Asp Arg Asp 
465                 470                 475                 480 


Pro Glu Glu Arg His Asp Leu Ser Arg Glu Tyr Pro His Ile Val Thr 
                485                 490                 495     


Lys Leu Leu Ser Arg Leu Gln Phe Tyr His Lys His Ser Val Pro Val 
            500                 505                 510         


Tyr Phe Pro Ala Gln Asp Pro Arg Cys Asp Pro Lys Ala Thr Gly Val 
        515                 520                 525             


Trp Gly Pro Trp Met 
    530             


<210> 2
<211> 1602
<212> DNA
<213> Homo sapiens

<400> 2
atgggtccgc gcggcgcggc gagcttgccc cgaggccccg gacctcggcg gctgctcctc       60

cccgtcgtcc tcccgctgct gctgctgctg ttgttggcgc cgccgggctc gggcgccggg      120

gccagccggc cgccccacct ggtcttcttg ctggcagacg acctaggctg gaacgacgtc      180

ggcttccacg gctcccgcat ccgcacgccg cacctggacg cgctggcggc cggcggggtg      240

ctcctggaca actactacac gcagccgctg tgcacgccgt cgcggagcca gctgctcact      300

ggccgctacc agatccgtac aggtttacag caccaaataa tctggccctg tcagcccagc      360

tgtgttcctc tggatgaaaa actcctgccc cagctcctaa aagaagcagg ttatactacc      420

catatggtcg gaaaatggca cctgggaatg taccggaaag aatgccttcc aacccgccga      480

ggatttgata cctactttgg atatctcctg ggtagtgaag attattattc ccatgaacgc      540

tgtacattaa ttgacgctct gaatgtcaca cgatgtgctc ttgattttcg agatggcgaa      600

gaagttgcaa caggatataa aaatatgtat tcaacaaaca tattcaccaa aagggctata      660

gccctcataa ctaaccatcc accagagaag cctctgtttc tctaccttgc tctccagtct      720

gtgcatgagc cccttcaggt ccctgaggaa tacttgaagc catatgactt tatccaagac      780

aagaacaggc atcactatgc aggaatggtg tcccttatgg atgaagcagt aggaaatgtc      840

actgcagctt taaaaagcag tgggctctgg aacaacacgg tgttcatctt ttctacagat      900

aacggagggc agactttggc agggggtaat aactggcccc ttcgaggaag aaaatggagc      960

ctgtgggaag gaggcgtccg aggggtgggc tttgtggcaa gccccttgct gaagcagaag     1020

ggcgtgaaga accgggagct catccacatc tctgactggc tgccaacact cgtgaagctg     1080

gccaggggac acaccaatgg cacaaagcct ctggatggct tcgacgtgtg gaaaaccatc     1140

agtgaaggaa gcccatcccc cagaattgag ctgctgcata atattgaccc gaacttcgtg     1200

gactcttcac cgtgtcccag gaacagcatg gctccagcaa aggatgactc ttctcttcca     1260

gaatattcag cctttaacac atctgtccat gctgcaatta gacatggaaa ttggaaactc     1320

ctcacgggct acccaggctg tggttactgg ttccctccac cgtctcaata caatgtttct     1380

gagataccct catcagaccc accaaccaag accctctggc tctttgatat tgatcgggac     1440

cctgaagaaa gacatgacct gtccagagaa tatcctcaca tcgtcacaaa gctcctgtcc     1500

cgcctacagt tctaccataa acactcagtc cccgtgtact tccctgcaca ggacccccgc     1560

tgtgatccca aggccactgg ggtgtggggc ccttggatgt ag                        1602


<210> 3
<211> 514
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Glu Leu Gly Leu Ser Trp Val Val Leu Ala Ala Leu Leu Gln Gly 
1               5                   10                  15      


Val Gln Ala Ala Gly Ala Ser Arg Pro Pro His Leu Val Phe Leu Leu 
            20                  25                  30          


Ala Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His Gly Ser Arg Ile 
        35                  40                  45              


Arg Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly Val Leu Leu Asp 
    50                  55                  60                  


Asn Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg Ser Gln Leu Leu 
65                  70                  75                  80  


Thr Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His Gln Ile Ile Trp 
                85                  90                  95      


Pro Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys Leu Leu Pro Gln 
            100                 105                 110         


Leu Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val Gly Lys Trp His 
        115                 120                 125             


Leu Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg Arg Gly Phe Asp 
    130                 135                 140                 


Thr Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr Tyr Ser His Glu 
145                 150                 155                 160 


Arg Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg Cys Ala Leu Asp 
                165                 170                 175     


Phe Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys Asn Met Tyr Ser 
            180                 185                 190         


Thr Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile Thr Asn His Pro 
        195                 200                 205             


Pro Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln Ser Val His Glu 
    210                 215                 220                 


Pro Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr Asp Phe Ile Gln 
225                 230                 235                 240 


Asp Lys Asn Arg His His Tyr Ala Gly Met Val Ser Leu Met Asp Glu 
                245                 250                 255     


Ala Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser Gly Leu Trp Asn 
            260                 265                 270         


Asn Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly Gln Thr Leu Ala 
        275                 280                 285             


Gly Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp Ser Leu Trp Glu 
    290                 295                 300                 


Gly Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro Leu Leu Lys Gln 
305                 310                 315                 320 


Lys Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser Asp Trp Leu Pro 
                325                 330                 335     


Thr Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly Thr Lys Pro Leu 
            340                 345                 350         


Asp Gly Phe Asp Val Trp Lys Thr Ile Ser Glu Gly Ser Pro Ser Pro 
        355                 360                 365             


Arg Ile Glu Leu Leu His Asn Ile Asp Pro Asn Phe Val Asp Ser Ser 
    370                 375                 380                 


Pro Cys Pro Arg Asn Ser Met Ala Pro Ala Lys Asp Asp Ser Ser Leu 
385                 390                 395                 400 


Pro Glu Tyr Ser Ala Phe Asn Thr Ser Val His Ala Ala Ile Arg His 
                405                 410                 415     


Gly Asn Trp Lys Leu Leu Thr Gly Tyr Pro Gly Cys Gly Tyr Trp Phe 
            420                 425                 430         


Pro Pro Pro Ser Gln Tyr Asn Val Ser Glu Ile Pro Ser Ser Asp Pro 
        435                 440                 445             


Pro Thr Lys Thr Leu Trp Leu Phe Asp Ile Asp Arg Asp Pro Glu Glu 
    450                 455                 460                 


Arg His Asp Leu Ser Arg Glu Tyr Pro His Ile Val Thr Lys Leu Leu 
465                 470                 475                 480 


Ser Arg Leu Gln Phe Tyr His Lys His Ser Val Pro Val Tyr Phe Pro 
                485                 490                 495     


Ala Gln Asp Pro Arg Cys Asp Pro Lys Ala Thr Gly Val Trp Gly Pro 
            500                 505                 510         


Trp Met 
        


<210> 4
<211> 1545
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
atggagctgg ggctgagctg ggtggtcctg gctgctcttt tacaaggtgt ccaggctgcc       60

ggggccagcc ggccgcccca cctggtcttc ttgctggcag acgacctagg ctggaacgac      120

gtcggcttcc acggctcccg catccgcacg ccgcacctgg acgcgctggc ggccggcggg      180

gtgctcctgg acaactacta cacgcagccg ctgtgcacgc cgtcgcggag ccagctgctc      240

actggccgct accagatccg tacaggttta cagcaccaaa taatctggcc ctgtcagccc      300

agctgtgttc ctctggatga aaaactcctg ccccagctcc taaaagaagc aggttatact      360

acccatatgg tcggaaaatg gcacctggga atgtaccgga aagaatgcct tccaacccgc      420

cgaggatttg atacctactt tggatatctc ctgggtagtg aagattatta ttcccatgaa      480

cgctgtacat taattgacgc tctgaatgtc acacgatgtg ctcttgattt tcgagatggc      540

gaagaagttg caacaggata taaaaatatg tattcaacaa acatattcac caaaagggct      600

atagccctca taactaacca tccaccagag aagcctctgt ttctctacct tgctctccag      660

tctgtgcatg agccccttca ggtccctgag gaatacttga agccatatga ctttatccaa      720

gacaagaaca ggcatcacta tgcaggaatg gtgtccctta tggatgaagc agtaggaaat      780

gtcactgcag ctttaaaaag cagtgggctc tggaacaaca cggtgttcat cttttctaca      840

gataacggag ggcagacttt ggcagggggt aataactggc cccttcgagg aagaaaatgg      900

agcctgtggg aaggaggcgt ccgaggggtg ggctttgtgg caagcccctt gctgaagcag      960

aagggcgtga agaaccggga gctcatccac atctctgact ggctgccaac actcgtgaag     1020

ctggccaggg gacacaccaa tggcacaaag cctctggatg gcttcgacgt gtggaaaacc     1080

atcagtgaag gaagcccatc ccccagaatt gagctgctgc ataatattga cccgaacttc     1140

gtggactctt caccgtgtcc caggaacagc atggctccag caaaggatga ctcttctctt     1200

ccagaatatt cagcctttaa cacatctgtc catgctgcaa ttagacatgg aaattggaaa     1260

ctcctcacgg gctacccagg ctgtggttac tggttccctc caccgtctca atacaatgtt     1320

tctgagatac cctcatcaga cccaccaacc aagaccctct ggctctttga tattgatcgg     1380

gaccctgaag aaagacatga cctgtccaga gaatatcctc acatcgtcac aaagctcctg     1440

tcccgcctac agttctacca taaacactca gtccccgtgt acttccctgc acaggacccc     1500

cgctgtgatc ccaaggccac tggggtgtgg ggcccttgga tgtag                     1545


<210> 5
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Met Glu Leu Gly Leu Ser Trp Val Val Leu Ala Ala Leu Leu Gln Gly 
1               5                   10                  15      


Val Gln Ala 
            


<210> 6
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
atggagctgg ggctgagctg ggtggtcctg gctgctcttt tacaaggtgt ccaggct          57


<210> 7
<211> 518
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ser Gly Ala Gly Ala Ser Arg Pro Pro His Leu 
            20                  25                  30          


Val Phe Leu Leu Ala Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His 
        35                  40                  45              


Gly Ser Arg Ile Arg Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly 
    50                  55                  60                  


Val Leu Leu Asp Asn Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg 
65                  70                  75                  80  


Ser Gln Leu Leu Thr Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His 
                85                  90                  95      


Gln Ile Ile Trp Pro Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys 
            100                 105                 110         


Leu Leu Pro Gln Leu Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val 
        115                 120                 125             


Gly Lys Trp His Leu Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg 
    130                 135                 140                 


Arg Gly Phe Asp Thr Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr 
145                 150                 155                 160 


Tyr Ser His Glu Arg Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg 
                165                 170                 175     


Cys Ala Leu Asp Phe Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys 
            180                 185                 190         


Asn Met Tyr Ser Thr Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile 
        195                 200                 205             


Thr Asn His Pro Pro Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln 
    210                 215                 220                 


Ser Val His Glu Pro Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr 
225                 230                 235                 240 


Asp Phe Ile Gln Asp Lys Asn Arg His His Tyr Ala Gly Met Val Ser 
                245                 250                 255     


Leu Met Asp Glu Ala Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser 
            260                 265                 270         


Gly Leu Trp Asn Asn Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly 
        275                 280                 285             


Gln Thr Leu Ala Gly Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp 
    290                 295                 300                 


Ser Leu Trp Glu Gly Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro 
305                 310                 315                 320 


Leu Leu Lys Gln Lys Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser 
                325                 330                 335     


Asp Trp Leu Pro Thr Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly 
            340                 345                 350         


Thr Lys Pro Leu Asp Gly Phe Asp Val Trp Lys Thr Ile Ser Glu Gly 
        355                 360                 365             


Ser Pro Ser Pro Arg Ile Glu Leu Leu His Asn Ile Asp Pro Asn Phe 
    370                 375                 380                 


Val Asp Ser Ser Pro Cys Pro Arg Asn Ser Met Ala Pro Ala Lys Asp 
385                 390                 395                 400 


Asp Ser Ser Leu Pro Glu Tyr Ser Ala Phe Asn Thr Ser Val His Ala 
                405                 410                 415     


Ala Ile Arg His Gly Asn Trp Lys Leu Leu Thr Gly Tyr Pro Gly Cys 
            420                 425                 430         


Gly Tyr Trp Phe Pro Pro Pro Ser Gln Tyr Asn Val Ser Glu Ile Pro 
        435                 440                 445             


Ser Ser Asp Pro Pro Thr Lys Thr Leu Trp Leu Phe Asp Ile Asp Arg 
    450                 455                 460                 


Asp Pro Glu Glu Arg His Asp Leu Ser Arg Glu Tyr Pro His Ile Val 
465                 470                 475                 480 


Thr Lys Leu Leu Ser Arg Leu Gln Phe Tyr His Lys His Ser Val Pro 
                485                 490                 495     


Val Tyr Phe Pro Ala Gln Asp Pro Arg Cys Asp Pro Lys Ala Thr Gly 
            500                 505                 510         


Val Trp Gly Pro Trp Met 
        515             


<210> 8
<211> 1557
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gactcgggcg ccggggccag ccggccgccc cacctggtct tcttgctggc agacgaccta      120

ggctggaacg acgtcggctt ccacggctcc cgcatccgca cgccgcacct ggacgcgctg      180

gcggccggcg gggtgctcct ggacaactac tacacgcagc cgctgtgcac gccgtcgcgg      240

agccagctgc tcactggccg ctaccagatc cgtacaggtt tacagcacca aataatctgg      300

ccctgtcagc ccagctgtgt tcctctggat gaaaaactcc tgccccagct cctaaaagaa      360

gcaggttata ctacccatat ggtcggaaaa tggcacctgg gaatgtaccg gaaagaatgc      420

cttccaaccc gccgaggatt tgatacctac tttggatatc tcctgggtag tgaagattat      480

tattcccatg aacgctgtac attaattgac gctctgaatg tcacacgatg tgctcttgat      540

tttcgagatg gcgaagaagt tgcaacagga tataaaaata tgtattcaac aaacatattc      600

accaaaaggg ctatagccct cataactaac catccaccag agaagcctct gtttctctac      660

cttgctctcc agtctgtgca tgagcccctt caggtccctg aggaatactt gaagccatat      720

gactttatcc aagacaagaa caggcatcac tatgcaggaa tggtgtccct tatggatgaa      780

gcagtaggaa atgtcactgc agctttaaaa agcagtgggc tctggaacaa cacggtgttc      840

atcttttcta cagataacgg agggcagact ttggcagggg gtaataactg gccccttcga      900

ggaagaaaat ggagcctgtg ggaaggaggc gtccgagggg tgggctttgt ggcaagcccc      960

ttgctgaagc agaagggcgt gaagaaccgg gagctcatcc acatctctga ctggctgcca     1020

acactcgtga agctggccag gggacacacc aatggcacaa agcctctgga tggcttcgac     1080

gtgtggaaaa ccatcagtga aggaagccca tcccccagaa ttgagctgct gcataatatt     1140

gacccgaact tcgtggactc ttcaccgtgt cccaggaaca gcatggctcc agcaaaggat     1200

gactcttctc ttccagaata ttcagccttt aacacatctg tccatgctgc aattagacat     1260

ggaaattgga aactcctcac gggctaccca ggctgtggtt actggttccc tccaccgtct     1320

caatacaatg tttctgagat accctcatca gacccaccaa ccaagaccct ctggctcttt     1380

gatattgatc gggaccctga agaaagacat gacctgtcca gagaatatcc tcacatcgtc     1440

acaaagctcc tgtcccgcct acagttctac cataaacact cagtccccgt gtacttccct     1500

gcacaggacc cccgctgtga tcccaaggcc actggggtgt ggggcccttg gatgtag        1557


<210> 9
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp 
            20      


<210> 10
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gac                                                                     63


<210> 11
<211> 516
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala 
1               5                   10                  15      


Leu Val Thr Asn Ser Ala Gly Ala Ser Arg Pro Pro His Leu Val Phe 
            20                  25                  30          


Leu Leu Ala Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His Gly Ser 
        35                  40                  45              


Arg Ile Arg Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly Val Leu 
    50                  55                  60                  


Leu Asp Asn Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg Ser Gln 
65                  70                  75                  80  


Leu Leu Thr Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His Gln Ile 
                85                  90                  95      


Ile Trp Pro Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys Leu Leu 
            100                 105                 110         


Pro Gln Leu Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val Gly Lys 
        115                 120                 125             


Trp His Leu Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg Arg Gly 
    130                 135                 140                 


Phe Asp Thr Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr Tyr Ser 
145                 150                 155                 160 


His Glu Arg Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg Cys Ala 
                165                 170                 175     


Leu Asp Phe Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys Asn Met 
            180                 185                 190         


Tyr Ser Thr Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile Thr Asn 
        195                 200                 205             


His Pro Pro Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln Ser Val 
    210                 215                 220                 


His Glu Pro Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr Asp Phe 
225                 230                 235                 240 


Ile Gln Asp Lys Asn Arg His His Tyr Ala Gly Met Val Ser Leu Met 
                245                 250                 255     


Asp Glu Ala Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser Gly Leu 
            260                 265                 270         


Trp Asn Asn Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly Gln Thr 
        275                 280                 285             


Leu Ala Gly Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp Ser Leu 
    290                 295                 300                 


Trp Glu Gly Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro Leu Leu 
305                 310                 315                 320 


Lys Gln Lys Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser Asp Trp 
                325                 330                 335     


Leu Pro Thr Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly Thr Lys 
            340                 345                 350         


Pro Leu Asp Gly Phe Asp Val Trp Lys Thr Ile Ser Glu Gly Ser Pro 
        355                 360                 365             


Ser Pro Arg Ile Glu Leu Leu His Asn Ile Asp Pro Asn Phe Val Asp 
    370                 375                 380                 


Ser Ser Pro Cys Pro Arg Asn Ser Met Ala Pro Ala Lys Asp Asp Ser 
385                 390                 395                 400 


Ser Leu Pro Glu Tyr Ser Ala Phe Asn Thr Ser Val His Ala Ala Ile 
                405                 410                 415     


Arg His Gly Asn Trp Lys Leu Leu Thr Gly Tyr Pro Gly Cys Gly Tyr 
            420                 425                 430         


Trp Phe Pro Pro Pro Ser Gln Tyr Asn Val Ser Glu Ile Pro Ser Ser 
        435                 440                 445             


Asp Pro Pro Thr Lys Thr Leu Trp Leu Phe Asp Ile Asp Arg Asp Pro 
    450                 455                 460                 


Glu Glu Arg His Asp Leu Ser Arg Glu Tyr Pro His Ile Val Thr Lys 
465                 470                 475                 480 


Leu Leu Ser Arg Leu Gln Phe Tyr His Lys His Ser Val Pro Val Tyr 
                485                 490                 495     


Phe Pro Ala Gln Asp Pro Arg Cys Asp Pro Lys Ala Thr Gly Val Trp 
            500                 505                 510         


Gly Pro Trp Met 
        515     


<210> 12
<211> 1551
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
atgatgtaca ggatgcaact cctgtcttgc attgcactaa gtcttgcact tgtcacgaat       60

tcggccgggg ccagccggcc gccccacctg gtcttcttgc tggcagacga cctaggctgg      120

aacgacgtcg gcttccacgg ctcccgcatc cgcacgccgc acctggacgc gctggcggcc      180

ggcggggtgc tcctggacaa ctactacacg cagccgctgt gcacgccgtc gcggagccag      240

ctgctcactg gccgctacca gatccgtaca ggtttacagc accaaataat ctggccctgt      300

cagcccagct gtgttcctct ggatgaaaaa ctcctgcccc agctcctaaa agaagcaggt      360

tatactaccc atatggtcgg aaaatggcac ctgggaatgt accggaaaga atgccttcca      420

acccgccgag gatttgatac ctactttgga tatctcctgg gtagtgaaga ttattattcc      480

catgaacgct gtacattaat tgacgctctg aatgtcacac gatgtgctct tgattttcga      540

gatggcgaag aagttgcaac aggatataaa aatatgtatt caacaaacat attcaccaaa      600

agggctatag ccctcataac taaccatcca ccagagaagc ctctgtttct ctaccttgct      660

ctccagtctg tgcatgagcc ccttcaggtc cctgaggaat acttgaagcc atatgacttt      720

atccaagaca agaacaggca tcactatgca ggaatggtgt cccttatgga tgaagcagta      780

ggaaatgtca ctgcagcttt aaaaagcagt gggctctgga acaacacggt gttcatcttt      840

tctacagata acggagggca gactttggca gggggtaata actggcccct tcgaggaaga      900

aaatggagcc tgtgggaagg aggcgtccga ggggtgggct ttgtggcaag ccccttgctg      960

aagcagaagg gcgtgaagaa ccgggagctc atccacatct ctgactggct gccaacactc     1020

gtgaagctgg ccaggggaca caccaatggc acaaagcctc tggatggctt cgacgtgtgg     1080

aaaaccatca gtgaaggaag cccatccccc agaattgagc tgctgcataa tattgacccg     1140

aacttcgtgg actcttcacc gtgtcccagg aacagcatgg ctccagcaaa ggatgactct     1200

tctcttccag aatattcagc ctttaacaca tctgtccatg ctgcaattag acatggaaat     1260

tggaaactcc tcacgggcta cccaggctgt ggttactggt tccctccacc gtctcaatac     1320

aatgtttctg agataccctc atcagaccca ccaaccaaga ccctctggct ctttgatatt     1380

gatcgggacc ctgaagaaag acatgacctg tccagagaat atcctcacat cgtcacaaag     1440

ctcctgtccc gcctacagtt ctaccataaa cactcagtcc ccgtgtactt ccctgcacag     1500

gacccccgct gtgatcccaa ggccactggg gtgtggggcc cttggatgta g              1551


<210> 13
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Met Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala 
1               5                   10                  15      


Leu Val Thr Asn Ser 
            20      


<210> 14
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
atgatgtaca ggatgcaact cctgtcttgc attgcactaa gtcttgcact tgtcacgaat       60

tcg                                                                     63


<210> 15
<211> 6344
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
ttaaccctag aaagatagtc tgcgtaaaat tgacgcatgc attcttgaaa tattgctctc       60

tctttctaaa tagcgcgaat ccgtcgctgt gcatttagga catctcagtc gccgcttgga      120

gctcccgtga ggcgtgcttg tcaatgcggt aagtgtcact gattttgaac tataacgacc      180

gcgtgagtca aaatgacgca tgattatctt ttacgtgact tttaagattt aactcatacg      240

ataattatat tgttatttca tgttctactt acgtgataac ttattatata tatattttct      300

tgttatagat atcatcaact ttgtatagaa aagttgggct ccggtgcccg tcagtgggca      360

gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt      420

gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt      480

tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt      540

cgcaacgggt ttgccgccag aacacaggta agtgccgtgt gtggttcccg cgggcctggc      600

ctctttacgg gttatggccc ttgcgtgcct tgaattactt ccacctggct gcagtacgtg      660

attcttgatc ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa      720

ggagcccctt cgcctcgtgc ttgagttgag gcctggcctg ggcgctgggg ccgccgcgtg      780

cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa      840

aatttttgat gacctgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc      900

caagatctgc acactggtat ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg      960

tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg     1020

gggtagtctc aagctggccg gcctgctctg gtgcctggtc tcgcgccgcc gtgtatcgcc     1080

ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg     1140

cttcccggcc ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg     1200

ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac     1260

tccacggagt accgggcgcc gtccaggcac ctcgattagt tctcgagctt ttggagtacg     1320

tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg     1380

gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt tgcccttttt     1440

gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca     1500

tttcaggtgt cgtgacaagt ttgtacaaaa aagcaggctg ccaccatggg tccgcgcggc     1560

gcggcgagct tgccccgagg ccccggacct cggcggctgc tcctccccgt cgtcctcccg     1620

ctgctgctgc tgctgttgtt ggcgccgccg ggctcgggcg ccggggccag ccggccgccc     1680

cacctggtct tcttgctggc agacgaccta ggctggaacg acgtcggctt ccacggctcc     1740

cgcatccgca cgccgcacct ggacgcgctg gcggccggcg gggtgctcct ggacaactac     1800

tacacgcagc cgctgtgcac gccgtcgcgg agccagctgc tcactggccg ctaccagatc     1860

cgtacaggtt tacagcacca aataatctgg ccctgtcagc ccagctgtgt tcctctggat     1920

gaaaaactcc tgccccagct cctaaaagaa gcaggttata ctacccatat ggtcggaaaa     1980

tggcacctgg gaatgtaccg gaaagaatgc cttccaaccc gccgaggatt tgatacctac     2040

tttggatatc tcctgggtag tgaagattat tattcccatg aacgctgtac attaattgac     2100

gctctgaatg tcacacgatg tgctcttgat tttcgagatg gcgaagaagt tgcaacagga     2160

tataaaaata tgtattcaac aaacatattc accaaaaggg ctatagccct cataactaac     2220

catccaccag agaagcctct gtttctctac cttgctctcc agtctgtgca tgagcccctt     2280

caggtccctg aggaatactt gaagccatat gactttatcc aagacaagaa caggcatcac     2340

tatgcaggaa tggtgtccct tatggatgaa gcagtaggaa atgtcactgc agctttaaaa     2400

agcagtgggc tctggaacaa cacggtgttc atcttttcta cagataacgg agggcagact     2460

ttggcagggg gtaataactg gccccttcga ggaagaaaat ggagcctgtg ggaaggaggc     2520

gtccgagggg tgggctttgt ggcaagcccc ttgctgaagc agaagggcgt gaagaaccgg     2580

gagctcatcc acatctctga ctggctgcca acactcgtga agctggccag gggacacacc     2640

aatggcacaa agcctctgga tggcttcgac gtgtggaaaa ccatcagtga aggaagccca     2700

tcccccagaa ttgagctgct gcataatatt gacccgaact tcgtggactc ttcaccgtgt     2760

cccaggaaca gcatggctcc agcaaaggat gactcttctc ttccagaata ttcagccttt     2820

aacacatctg tccatgctgc aattagacat ggaaattgga aactcctcac gggctaccca     2880

ggctgtggtt actggttccc tccaccgtct caatacaatg tttctgagat accctcatca     2940

gacccaccaa ccaagaccct ctggctcttt gatattgatc gggaccctga agaaagacat     3000

gacctgtcca gagaatatcc tcacatcgtc acaaagctcc tgtcccgcct acagttctac     3060

cataaacact cagtccccgt gtacttccct gcacaggacc cccgctgtga tcccaaggcc     3120

actggggtgt ggggcccttg gatgtagacc cagctttctt gtacaaagtg gtgatcctca     3180

ggtgcaggct gcctatcaga aggtggtggc tggtgtggcc aatgccctgg ctcacaaata     3240

ccactgagat ctttttccct ctgccaaaaa ttatggggac atcatgaagc cccttgagca     3300

tctgacttct ggctaataaa ggaaatttat tttcattgca atagtgtgtt ggaatttttt     3360

gtgtctctca ctcggaagga catatgggag ggcaaatcat ttaaaacatc agaatgagta     3420

tttggtttag agtttggcaa catatgccca tatgctggct gccatgaaca aaggttggct     3480

ataaagaggt catcagtata tgaaacagcc ccctgctgtc cattccttat tccatagaaa     3540

agccttgact tgaggttaga ttttttttat attttgtttt gtgttatttt tttctttaac     3600

atccctaaaa ttttccttac atgttttact agccagattt ttcctcctct cctgactact     3660

cccagtcata gctgtccctc ttctcttatg gagatccctc gacctgcagc ccaagcttcg     3720

cgttgacatt gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat     3780

agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg     3840

cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata     3900

gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta     3960

catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc     4020

gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca gtacatctac     4080

gtattagtca tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga     4140

tagcggtttg actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg     4200

ttttggcacc aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg     4260

caaatgggcg gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact     4320

agagaaccca ctgcgccacc atggtgagca agggcgagga gctgttcacc ggggtggtgc     4380

ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg     4440

gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc     4500

tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc     4560

gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg     4620

tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga     4680

agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg     4740

acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca     4800

tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg     4860

acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg     4920

tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg     4980

agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca     5040

tggacgagct gtacaagatg accgagtaca agcccacggt gcgcctcgcc acccgcgacg     5100

acgtccccag ggccgtacgc accctcgccg ccgcgttcgc cgactacccc gccacgcgcc     5160

acaccgtcga tccggaccgc cacatcgagc gggtcaccga gctgcaagaa ctcttcctca     5220

cgcgcgtcgg gctcgacatc ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg     5280

tctggaccac gccggagagc gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca     5340

tggccgagtt gagcggttcc cggctggccg cgcagcaaca gatggaaggc ctcctggcgc     5400

cgcaccggcc caaggagccc gcgtggttcc tggccaccgt cggcgtctcg cccgaccacc     5460

agggcaaggg tctgggcagc gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg     5520

gggtgcccgc cttcctggag acctccgcgc cccgcaacct ccccttctac gagcggctcg     5580

gcttcaccgt caccgccgac gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc     5640

gcaagcccgg tgcctgactc gagtctagag ggcccgttta aacccgctga tcagcctcga     5700

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc     5760

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc     5820

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt     5880

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggtggct cgagttaatt     5940

aacgagagca taatattgat atgtgccaaa gttgtttctg actgactaat aagtataatt     6000

tgtttctatt atgtataggt taagctaatt acttatttta taatacaaca tgactgtttt     6060

taaagtacaa aataagttta tttttgtaaa agagagaatg tttaaaagtt ttgttacttt     6120

atagaagaaa ttttgagttt ttgttttttt ttaataaata aataaacata aataaattgt     6180

ttgttgaatt tattattagt atgtaagtgt aaatataata aaacttaata tctattcaaa     6240

ttaataaata aacctcgata tacagaccga taaaacacat gcgtcaattt tacgcatgat     6300

tatctttaac gtacgtcaca atatgattat ctttctaggg ttaa                      6344


<210> 16
<211> 1179
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg       60

ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt      120

gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca      180

gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc      240

gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt      300

acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg aagtgggtgg      360

gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt tgaggcctgg      420

cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg tctcgctgct      480

ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct ttttttctgg      540

caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt ttttggggcc      600

gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg gggcctgcga      660

gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc tctggtgcct      720

ggtctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg gtcggcacca      780

gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc aaaatggagg      840

acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag ggcctttccg      900

tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag gcacctcgat      960

tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt ttatgcgatg     1020

gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca cttgatgtaa     1080

ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa gcctcagaca     1140

gtggttcaaa gtttttttct tccatttcag gtgtcgtga                            1179


<210> 17
<211> 1602
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
atgggtccgc gcggcgcggc gagcttgccc cgaggccccg gacctcggcg gctgctcctc       60

cccgtcgtcc tcccgctgct gctgctgctg ttgttggcgc cgccgggctc gggcgccggg      120

gccagccggc cgccccacct ggtcttcttg ctggcagacg acctaggctg gaacgacgtc      180

ggcttccacg gctcccgcat ccgcacgccg cacctggacg cgctggcggc cggcggggtg      240

ctcctggaca actactacac gcagccgctg tgcacgccgt cgcggagcca gctgctcact      300

ggccgctacc agatccgtac aggtttacag caccaaataa tctggccctg tcagcccagc      360

tgtgttcctc tggatgaaaa actcctgccc cagctcctaa aagaagcagg ttatactacc      420

catatggtcg gaaaatggca cctgggaatg taccggaaag aatgccttcc aacccgccga      480

ggatttgata cctactttgg atatctcctg ggtagtgaag attattattc ccatgaacgc      540

tgtacattaa ttgacgctct gaatgtcaca cgatgtgctc ttgattttcg agatggcgaa      600

gaagttgcaa caggatataa aaatatgtat tcaacaaaca tattcaccaa aagggctata      660

gccctcataa ctaaccatcc accagagaag cctctgtttc tctaccttgc tctccagtct      720

gtgcatgagc cccttcaggt ccctgaggaa tacttgaagc catatgactt tatccaagac      780

aagaacaggc atcactatgc aggaatggtg tcccttatgg atgaagcagt aggaaatgtc      840

actgcagctt taaaaagcag tgggctctgg aacaacacgg tgttcatctt ttctacagat      900

aacggagggc agactttggc agggggtaat aactggcccc ttcgaggaag aaaatggagc      960

ctgtgggaag gaggcgtccg aggggtgggc tttgtggcaa gccccttgct gaagcagaag     1020

ggcgtgaaga accgggagct catccacatc tctgactggc tgccaacact cgtgaagctg     1080

gccaggggac acaccaatgg cacaaagcct ctggatggct tcgacgtgtg gaaaaccatc     1140

agtgaaggaa gcccatcccc cagaattgag ctgctgcata atattgaccc gaacttcgtg     1200

gactcttcac cgtgtcccag gaacagcatg gctccagcaa aggatgactc ttctcttcca     1260

gaatattcag cctttaacac atctgtccat gctgcaatta gacatggaaa ttggaaactc     1320

ctcacgggct acccaggctg tggttactgg ttccctccac cgtctcaata caatgtttct     1380

gagataccct catcagaccc accaaccaag accctctggc tctttgatat tgatcgggac     1440

cctgaagaaa gacatgacct gtccagagaa tatcctcaca tcgtcacaaa gctcctgtcc     1500

cgcctacagt tctaccataa acactcagtc cccgtgtact tccctgcaca ggacccccgc     1560

tgtgatccca aggccactgg ggtgtggggc ccttggatgt ag                        1602


<210> 18
<211> 7472
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
ttaaccctag aaagatagtc tgcgtaaaat tgacgcatgc attcttgaaa tattgctctc       60

tctttctaaa tagcgcgaat ccgtcgctgt gcatttagga catctcagtc gccgcttgga      120

gctcccgtga ggcgtgcttg tcaatgcggt aagtgtcact gattttgaac tataacgacc      180

gcgtgagtca aaatgacgca tgattatctt ttacgtgact tttaagattt aactcatacg      240

ataattatat tgttatttca tgttctactt acgtgataac ttattatata tatattttct      300

tgttatagat atcatcaact ttgtatagaa aagttgggct ccggtgcccg tcagtgggca      360

gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt      420

gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt      480

tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt      540

cgcaacgggt ttgccgccag aacacaggta agtgccgtgt gtggttcccg cgggcctggc      600

ctctttacgg gttatggccc ttgcgtgcct tgaattactt ccacctggct gcagtacgtg      660

attcttgatc ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa      720

ggagcccctt cgcctcgtgc ttgagttgag gcctggcctg ggcgctgggg ccgccgcgtg      780

cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa      840

aatttttgat gacctgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc      900

caagatctgc acactggtat ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg      960

tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg     1020

gggtagtctc aagctggccg gcctgctctg gtgcctggtc tcgcgccgcc gtgtatcgcc     1080

ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg     1140

cttcccggcc ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg     1200

ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac     1260

tccacggagt accgggcgcc gtccaggcac ctcgattagt tctcgagctt ttggagtacg     1320

tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg     1380

gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt tgcccttttt     1440

gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca     1500

tttcaggtgt cgtgacaagt ttgtacaaaa aagcaggctg ccaccatggg tccgcgcggc     1560

gcggcgagct tgccccgagg ccccggacct cggcggctgc tcctccccgt cgtcctcccg     1620

ctgctgctgc tgctgttgtt ggcgccgccg ggctcgggcg ccggggccag ccggccgccc     1680

cacctggtct tcttgctggc agacgaccta ggctggaacg acgtcggctt ccacggctcc     1740

cgcatccgca cgccgcacct ggacgcgctg gcggccggcg gggtgctcct ggacaactac     1800

tacacgcagc cgctgtgcac gccgtcgcgg agccagctgc tcactggccg ctaccagatc     1860

cgtacaggtt tacagcacca aataatctgg ccctgtcagc ccagctgtgt tcctctggat     1920

gaaaaactcc tgccccagct cctaaaagaa gcaggttata ctacccatat ggtcggaaaa     1980

tggcacctgg gaatgtaccg gaaagaatgc cttccaaccc gccgaggatt tgatacctac     2040

tttggatatc tcctgggtag tgaagattat tattcccatg aacgctgtac attaattgac     2100

gctctgaatg tcacacgatg tgctcttgat tttcgagatg gcgaagaagt tgcaacagga     2160

tataaaaata tgtattcaac aaacatattc accaaaaggg ctatagccct cataactaac     2220

catccaccag agaagcctct gtttctctac cttgctctcc agtctgtgca tgagcccctt     2280

caggtccctg aggaatactt gaagccatat gactttatcc aagacaagaa caggcatcac     2340

tatgcaggaa tggtgtccct tatggatgaa gcagtaggaa atgtcactgc agctttaaaa     2400

agcagtgggc tctggaacaa cacggtgttc atcttttcta cagataacgg agggcagact     2460

ttggcagggg gtaataactg gccccttcga ggaagaaaat ggagcctgtg ggaaggaggc     2520

gtccgagggg tgggctttgt ggcaagcccc ttgctgaagc agaagggcgt gaagaaccgg     2580

gagctcatcc acatctctga ctggctgcca acactcgtga agctggccag gggacacacc     2640

aatggcacaa agcctctgga tggcttcgac gtgtggaaaa ccatcagtga aggaagccca     2700

tcccccagaa ttgagctgct gcataatatt gacccgaact tcgtggactc ttcaccgtgt     2760

cccaggaaca gcatggctcc agcaaaggat gactcttctc ttccagaata ttcagccttt     2820

aacacatctg tccatgctgc aattagacat ggaaattgga aactcctcac gggctaccca     2880

ggctgtggtt actggttccc tccaccgtct caatacaatg tttctgagat accctcatca     2940

gacccaccaa ccaagaccct ctggctcttt gatattgatc gggaccctga agaaagacat     3000

gacctgtcca gagaatatcc tcacatcgtc acaaagctcc tgtcccgcct acagttctac     3060

cataaacact cagtccccgt gtacttccct gcacaggacc cccgctgtga tcccaaggcc     3120

actggggtgt ggggcccttg gatgggaagc ggagccacga acttctctct gttaaagcaa     3180

gcaggagatg ttgaagaaaa ccccgggcct atggtggccc gaggcagccg ggatgacagc     3240

tctccccagg aatcctgctg cctgctgaga aacatggtca gcaagtcccg ctggaagctc     3300

ctggccatgt tggctctggt cctggtcgtc atggtgtggt attccatctc ccgggaagac     3360

aggtacatcg agctttttta ttttcccatc ccagagaaga aggagccgtg cctccagggt     3420

gaggcagaga gcaaggcctc taagctcttt ggcaactact cccgggatca gcccatcttc     3480

ctgcggcttg aggattattt ctgggtcaag acgccatctg cttacgagct gccctatggg     3540

accaagggga gtgaggatct gctcctccgg gtgctagcca tcaccagctc ctccatcccc     3600

aagaacatcc agagcctcag gtgccgccgc tgtgtggtcg tggggaacgg gcaccggctg     3660

cggaacagct cactgggaga tgccatcaac aagtacgatg tggtcatcag attgaacaat     3720

gccccagtgg ctggctatga gggtgacgtg ggctccaaga ccaccatgcg tctcttctac     3780

cctgaatctg cccacttcga ccccaaagta gaaaacaacc cagacacact cctcgtcctg     3840

gtagctttca aggcaatgga cttccactgg attgagacca tcctgagtga taagaagcgg     3900

gtgcgaaagg gtttctggaa acagcctccc ctcatctggg atgtcaatcc taaacagatt     3960

cggattctca accccttctt catggagatt gcagctgaca aactgctgag cctgccaatg     4020

caacagccac ggaagattaa gcagaagccc accacgggcc tgttggccat cacgctggcc     4080

ctccacctct gtgacttggt gcacattgcc ggctttggct acccagacgc ctacaacaag     4140

aagcagacca ttcactacta tgagcagatc acgctcaagt ccatggcggg gtcaggccat     4200

aatgtctccc aagaggccct ggccattaag cggatgctgg agatgggagc tatcaagaac     4260

ctcacgtcct tctgaaccca gctttcttgt acaaagtggt gatcctcagg tgcaggctgc     4320

ctatcagaag gtggtggctg gtgtggccaa tgccctggct cacaaatacc actgagatct     4380

ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc tgacttctgg     4440

ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt gtctctcact     4500

cggaaggaca tatgggaggg caaatcattt aaaacatcag aatgagtatt tggtttagag     4560

tttggcaaca tatgcccata tgctggctgc catgaacaaa ggttggctat aaagaggtca     4620

tcagtatatg aaacagcccc ctgctgtcca ttccttattc catagaaaag ccttgacttg     4680

aggttagatt ttttttatat tttgttttgt gttatttttt tctttaacat ccctaaaatt     4740

ttccttacat gttttactag ccagattttt cctcctctcc tgactactcc cagtcatagc     4800

tgtccctctt ctcttatgga gatccctcga cctgcagccc aagcttcgcg ttgacattga     4860

ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg     4920

gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc     4980

cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat     5040

tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat     5100

catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat     5160

gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc     5220

gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac     5280

tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa     5340

aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt     5400

aggcgtgtac ggtgggaggt ctatataagc agagctctct ggctaactag agaacccact     5460

gcgccaccat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg     5520

agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg     5580

ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct     5640

ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc     5700

acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca     5760

ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg     5820

acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc     5880

tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc     5940

agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc     6000

agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg     6060

acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc     6120

acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt     6180

acaagatgac cgagtacaag cccacggtgc gcctcgccac ccgcgacgac gtccccaggg     6240

ccgtacgcac cctcgccgcc gcgttcgccg actaccccgc cacgcgccac accgtcgatc     6300

cggaccgcca catcgagcgg gtcaccgagc tgcaagaact cttcctcacg cgcgtcgggc     6360

tcgacatcgg caaggtgtgg gtcgcggacg acggcgccgc ggtggcggtc tggaccacgc     6420

cggagagcgt cgaagcgggg gcggtgttcg ccgagatcgg cccgcgcatg gccgagttga     6480

gcggttcccg gctggccgcg cagcaacaga tggaaggcct cctggcgccg caccggccca     6540

aggagcccgc gtggttcctg gccaccgtcg gcgtctcgcc cgaccaccag ggcaagggtc     6600

tgggcagcgc cgtcgtgctc cccggagtgg aggcggccga gcgcgccggg gtgcccgcct     6660

tcctggagac ctccgcgccc cgcaacctcc ccttctacga gcggctcggc ttcaccgtca     6720

ccgccgacgt cgaggtgccc gaaggaccgc gcacctggtg catgacccgc aagcccggtg     6780

cctgactcga gtctagaggg cccgtttaaa cccgctgatc agcctcgact gtgccttcta     6840

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca     6900

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc     6960

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata     7020

gcaggcatgc tggggatgcg gtgggctcta tggtggctcg agttaattaa cgagagcata     7080

atattgatat gtgccaaagt tgtttctgac tgactaataa gtataatttg tttctattat     7140

gtataggtta agctaattac ttattttata atacaacatg actgttttta aagtacaaaa     7200

taagtttatt tttgtaaaag agagaatgtt taaaagtttt gttactttat agaagaaatt     7260

ttgagttttt gttttttttt aataaataaa taaacataaa taaattgttt gttgaattta     7320

ttattagtat gtaagtgtaa atataataaa acttaatatc tattcaaatt aataaataaa     7380

cctcgatata cagaccgata aaacacatgc gtcaatttta cgcatgatta tctttaacgt     7440

acgtcacaat atgattatct ttctagggtt aa                                   7472


<210> 19
<211> 7989
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
ttaaccctag aaagatagtc tgcgtaaaat tgacgcatgc attcttgaaa tattgctctc       60

tctttctaaa tagcgcgaat ccgtcgctgt gcatttagga catctcagtc gccgcttgga      120

gctcccgtga ggcgtgcttg tcaatgcggt aagtgtcact gattttgaac tataacgacc      180

gcgtgagtca aaatgacgca tgattatctt ttacgtgact tttaagattt aactcatacg      240

ataattatat tgttatttca tgttctactt acgtgataac ttattatata tatattttct      300

tgttatagat atcatcaact ttgtatagaa aagttgggct ccggtgcccg tcagtgggca      360

gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt      420

gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt      480

tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt      540

cgcaacgggt ttgccgccag aacacaggta agtgccgtgt gtggttcccg cgggcctggc      600

ctctttacgg gttatggccc ttgcgtgcct tgaattactt ccacctggct gcagtacgtg      660

attcttgatc ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa      720

ggagcccctt cgcctcgtgc ttgagttgag gcctggcctg ggcgctgggg ccgccgcgtg      780

cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa      840

aatttttgat gacctgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc      900

caagatctgc acactggtat ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg      960

tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg     1020

gggtagtctc aagctggccg gcctgctctg gtgcctggtc tcgcgccgcc gtgtatcgcc     1080

ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg     1140

cttcccggcc ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg     1200

ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac     1260

tccacggagt accgggcgcc gtccaggcac ctcgattagt tctcgagctt ttggagtacg     1320

tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg     1380

gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt tgcccttttt     1440

gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca     1500

tttcaggtgt cgtgacaagt ttgtacaaaa aagcaggctg ccaccatggg tccgcgcggc     1560

gcggcgagct tgccccgagg ccccggacct cggcggctgc tcctccccgt cgtcctcccg     1620

ctgctgctgc tgctgttgtt ggcgccgccg ggctcgggcg ccggggccag ccggccgccc     1680

cacctggtct tcttgctggc agacgaccta ggctggaacg acgtcggctt ccacggctcc     1740

cgcatccgca cgccgcacct ggacgcgctg gcggccggcg gggtgctcct ggacaactac     1800

tacacgcagc cgctgtgcac gccgtcgcgg agccagctgc tcactggccg ctaccagatc     1860

cgtacaggtt tacagcacca aataatctgg ccctgtcagc ccagctgtgt tcctctggat     1920

gaaaaactcc tgccccagct cctaaaagaa gcaggttata ctacccatat ggtcggaaaa     1980

tggcacctgg gaatgtaccg gaaagaatgc cttccaaccc gccgaggatt tgatacctac     2040

tttggatatc tcctgggtag tgaagattat tattcccatg aacgctgtac attaattgac     2100

gctctgaatg tcacacgatg tgctcttgat tttcgagatg gcgaagaagt tgcaacagga     2160

tataaaaata tgtattcaac aaacatattc accaaaaggg ctatagccct cataactaac     2220

catccaccag agaagcctct gtttctctac cttgctctcc agtctgtgca tgagcccctt     2280

caggtccctg aggaatactt gaagccatat gactttatcc aagacaagaa caggcatcac     2340

tatgcaggaa tggtgtccct tatggatgaa gcagtaggaa atgtcactgc agctttaaaa     2400

agcagtgggc tctggaacaa cacggtgttc atcttttcta cagataacgg agggcagact     2460

ttggcagggg gtaataactg gccccttcga ggaagaaaat ggagcctgtg ggaaggaggc     2520

gtccgagggg tgggctttgt ggcaagcccc ttgctgaagc agaagggcgt gaagaaccgg     2580

gagctcatcc acatctctga ctggctgcca acactcgtga agctggccag gggacacacc     2640

aatggcacaa agcctctgga tggcttcgac gtgtggaaaa ccatcagtga aggaagccca     2700

tcccccagaa ttgagctgct gcataatatt gacccgaact tcgtggactc ttcaccgtgt     2760

cccaggaaca gcatggctcc agcaaaggat gactcttctc ttccagaata ttcagccttt     2820

aacacatctg tccatgctgc aattagacat ggaaattgga aactcctcac gggctaccca     2880

ggctgtggtt actggttccc tccaccgtct caatacaatg tttctgagat accctcatca     2940

gacccaccaa ccaagaccct ctggctcttt gatattgatc gggaccctga agaaagacat     3000

gacctgtcca gagaatatcc tcacatcgtc acaaagctcc tgtcccgcct acagttctac     3060

cataaacact cagtccccgt gtacttccct gcacaggacc cccgctgtga tcccaaggcc     3120

actggggtgt ggggcccttg gatggcccct ctccctcccc cccccctaac gttactggcc     3180

gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat gttattttcc accatattgc     3240

cgtcttttgg caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta     3300

ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag     3360

ttcctctgga agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga     3420

accccccacc tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa gatacacctg     3480

caaaggcggc acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat     3540

ggctctcctc aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta     3600

tgggatctga tctggggcct cggtgcacat gctttacatg tgtttagtcg aggttaaaaa     3660

aacgtctagg ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgatgataat     3720

atggccacaa ccatggtggc ccgaggcagc cgggatgaca gctctcccca ggaatcctgc     3780

tgcctgctga gaaacatggt cagcaagtcc cgctggaagc tcctggccat gttggctctg     3840

gtcctggtcg tcatggtgtg gtattccatc tcccgggaag acaggtacat cgagcttttt     3900

tattttccca tcccagagaa gaaggagccg tgcctccagg gtgaggcaga gagcaaggcc     3960

tctaagctct ttggcaacta ctcccgggat cagcccatct tcctgcggct tgaggattat     4020

ttctgggtca agacgccatc tgcttacgag ctgccctatg ggaccaaggg gagtgaggat     4080

ctgctcctcc gggtgctagc catcaccagc tcctccatcc ccaagaacat ccagagcctc     4140

aggtgccgcc gctgtgtggt cgtggggaac gggcaccggc tgcggaacag ctcactggga     4200

gatgccatca acaagtacga tgtggtcatc agattgaaca atgccccagt ggctggctat     4260

gagggtgacg tgggctccaa gaccaccatg cgtctcttct accctgaatc tgcccacttc     4320

gaccccaaag tagaaaacaa cccagacaca ctcctcgtcc tggtagcttt caaggcaatg     4380

gacttccact ggattgagac catcctgagt gataagaagc gggtgcgaaa gggtttctgg     4440

aaacagcctc ccctcatctg ggatgtcaat cctaaacaga ttcggattct caaccccttc     4500

ttcatggaga ttgcagctga caaactgctg agcctgccaa tgcaacagcc acggaagatt     4560

aagcagaagc ccaccacggg cctgttggcc atcacgctgg ccctccacct ctgtgacttg     4620

gtgcacattg ccggctttgg ctacccagac gcctacaaca agaagcagac cattcactac     4680

tatgagcaga tcacgctcaa gtccatggcg gggtcaggcc ataatgtctc ccaagaggcc     4740

ctggccatta agcggatgct ggagatggga gctatcaaga acctcacgtc cttctgacaa     4800

ctttattata catagttgat cctcaggtgc aggctgccta tcagaaggtg gtggctggtg     4860

tggccaatgc cctggctcac aaataccact gagatctttt tccctctgcc aaaaattatg     4920

gggacatcat gaagcccctt gagcatctga cttctggcta ataaaggaaa tttattttca     4980

ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aaggacatat gggagggcaa     5040

atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc     5100

tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg     5160

ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt     5220

gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca     5280

gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat     5340

ccctcgacct gcagcccaag cttcgcgttg acattgatta ttgactagtt attaatagta     5400

atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac     5460

ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac     5520

gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt     5580

acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat     5640

tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga     5700

ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt     5760

ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca     5820

ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg     5880

tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta     5940

tataagcaga gctctctggc taactagaga acccactgcg ccaccatggt gagcaagggc     6000

gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc     6060

cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa gctgaccctg     6120

aagttcatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt gaccaccctg     6180

acctacggcg tgcagtgctt cagccgctac cccgaccaca tgaagcagca cgacttcttc     6240

aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa ggacgacggc     6300

aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag     6360

ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct ggagtacaac     6420

tacaacagcc acaacgtcta tatcatggcc gacaagcaga agaacggcat caaggtgaac     6480

ttcaagatcc gccacaacat cgaggacggc agcgtgcagc tcgccgacca ctaccagcag     6540

aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagcacccag     6600

tccgccctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg     6660

accgccgccg ggatcactct cggcatggac gagctgtaca agatgaccga gtacaagccc     6720

acggtgcgcc tcgccacccg cgacgacgtc cccagggccg tacgcaccct cgccgccgcg     6780

ttcgccgact accccgccac gcgccacacc gtcgatccgg accgccacat cgagcgggtc     6840

accgagctgc aagaactctt cctcacgcgc gtcgggctcg acatcggcaa ggtgtgggtc     6900

gcggacgacg gcgccgcggt ggcggtctgg accacgccgg agagcgtcga agcgggggcg     6960

gtgttcgccg agatcggccc gcgcatggcc gagttgagcg gttcccggct ggccgcgcag     7020

caacagatgg aaggcctcct ggcgccgcac cggcccaagg agcccgcgtg gttcctggcc     7080

accgtcggcg tctcgcccga ccaccagggc aagggtctgg gcagcgccgt cgtgctcccc     7140

ggagtggagg cggccgagcg cgccggggtg cccgccttcc tggagacctc cgcgccccgc     7200

aacctcccct tctacgagcg gctcggcttc accgtcaccg ccgacgtcga ggtgcccgaa     7260

ggaccgcgca cctggtgcat gacccgcaag cccggtgcct gactcgagtc tagagggccc     7320

gtttaaaccc gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc     7380

ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa     7440

aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg     7500

gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg     7560

ggctctatgg tggctcgagt taattaacga gagcataata ttgatatgtg ccaaagttgt     7620

ttctgactga ctaataagta taatttgttt ctattatgta taggttaagc taattactta     7680

ttttataata caacatgact gtttttaaag tacaaaataa gtttattttt gtaaaagaga     7740

gaatgtttaa aagttttgtt actttataga agaaattttg agtttttgtt tttttttaat     7800

aaataaataa acataaataa attgtttgtt gaatttatta ttagtatgta agtgtaaata     7860

taataaaact taatatctat tcaaattaat aaataaacct cgatatacag accgataaaa     7920

cacatgcgtc aattttacgc atgattatct ttaacgtacg tcacaatatg attatctttc     7980

tagggttaa                                                             7989


<210> 20
<211> 7888
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 20
ttaaccctag aaagatagtc tgcgtaaaat tgacgcatgc attcttgaaa tattgctctc       60

tctttctaaa tagcgcgaat ccgtcgctgt gcatttagga catctcagtc gccgcttgga      120

gctcccgtga ggcgtgcttg tcaatgcggt aagtgtcact gattttgaac tataacgacc      180

gcgtgagtca aaatgacgca tgattatctt ttacgtgact tttaagattt aactcatacg      240

ataattatat tgttatttca tgttctactt acgtgataac ttattatata tatattttct      300

tgttatagat atcatcaact ttgtatagaa aagttgggct ccggtgcccg tcagtgggca      360

gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt      420

gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt      480

tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt      540

cgcaacgggt ttgccgccag aacacaggta agtgccgtgt gtggttcccg cgggcctggc      600

ctctttacgg gttatggccc ttgcgtgcct tgaattactt ccacctggct gcagtacgtg      660

attcttgatc ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa      720

ggagcccctt cgcctcgtgc ttgagttgag gcctggcctg ggcgctgggg ccgccgcgtg      780

cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa      840

aatttttgat gacctgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc      900

caagatctgc acactggtat ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg      960

tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg     1020

gggtagtctc aagctggccg gcctgctctg gtgcctggtc tcgcgccgcc gtgtatcgcc     1080

ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg     1140

cttcccggcc ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg     1200

ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac     1260

tccacggagt accgggcgcc gtccaggcac ctcgattagt tctcgagctt ttggagtacg     1320

tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg     1380

gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt tgcccttttt     1440

gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca     1500

tttcaggtgt cgtgacaagt ttgtacaaaa aagcaggctg ccaccatggg tccgcgcggc     1560

gcggcgagct tgccccgagg ccccggacct cggcggctgc tcctccccgt cgtcctcccg     1620

ctgctgctgc tgctgttgtt ggcgccgccg ggctcgggcg ccggggccag ccggccgccc     1680

cacctggtct tcttgctggc agacgaccta ggctggaacg acgtcggctt ccacggctcc     1740

cgcatccgca cgccgcacct ggacgcgctg gcggccggcg gggtgctcct ggacaactac     1800

tacacgcagc cgctgtgcac gccgtcgcgg agccagctgc tcactggccg ctaccagatc     1860

cgtacaggtt tacagcacca aataatctgg ccctgtcagc ccagctgtgt tcctctggat     1920

gaaaaactcc tgccccagct cctaaaagaa gcaggttata ctacccatat ggtcggaaaa     1980

tggcacctgg gaatgtaccg gaaagaatgc cttccaaccc gccgaggatt tgatacctac     2040

tttggatatc tcctgggtag tgaagattat tattcccatg aacgctgtac attaattgac     2100

gctctgaatg tcacacgatg tgctcttgat tttcgagatg gcgaagaagt tgcaacagga     2160

tataaaaata tgtattcaac aaacatattc accaaaaggg ctatagccct cataactaac     2220

catccaccag agaagcctct gtttctctac cttgctctcc agtctgtgca tgagcccctt     2280

caggtccctg aggaatactt gaagccatat gactttatcc aagacaagaa caggcatcac     2340

tatgcaggaa tggtgtccct tatggatgaa gcagtaggaa atgtcactgc agctttaaaa     2400

agcagtgggc tctggaacaa cacggtgttc atcttttcta cagataacgg agggcagact     2460

ttggcagggg gtaataactg gccccttcga ggaagaaaat ggagcctgtg ggaaggaggc     2520

gtccgagggg tgggctttgt ggcaagcccc ttgctgaagc agaagggcgt gaagaaccgg     2580

gagctcatcc acatctctga ctggctgcca acactcgtga agctggccag gggacacacc     2640

aatggcacaa agcctctgga tggcttcgac gtgtggaaaa ccatcagtga aggaagccca     2700

tcccccagaa ttgagctgct gcataatatt gacccgaact tcgtggactc ttcaccgtgt     2760

cccaggaaca gcatggctcc agcaaaggat gactcttctc ttccagaata ttcagccttt     2820

aacacatctg tccatgctgc aattagacat ggaaattgga aactcctcac gggctaccca     2880

ggctgtggtt actggttccc tccaccgtct caatacaatg tttctgagat accctcatca     2940

gacccaccaa ccaagaccct ctggctcttt gatattgatc gggaccctga agaaagacat     3000

gacctgtcca gagaatatcc tcacatcgtc acaaagctcc tgtcccgcct acagttctac     3060

cataaacact cagtccccgt gtacttccct gcacaggacc cccgctgtga tcccaaggcc     3120

actggggtgt ggggcccttg gatgtagacc cagctttctt gtacaaagtg gcagacatga     3180

taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta     3240

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag     3300

ttaacaacaa caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt     3360

tttaaagcaa gtaaaacctc tacaaatgtg gtaggctccg gtgcccgtca gtgggcagag     3420

cgcacatcgc ccacagtccc cgagaagttg gggggagggg tcggcaattg atccggtgcc     3480

tagagaaggt ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt     3540

cccgagggtg ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc     3600

aacgggtttg ccgccagaac acagggccac catggtggcc cgaggcagcc gggatgacag     3660

ctctccccag gaatcctgct gcctgctgag aaacatggtc agcaagtccc gctggaagct     3720

cctggccatg ttggctctgg tcctggtcgt catggtgtgg tattccatct cccgggaaga     3780

caggtacatc gagctttttt attttcccat cccagagaag aaggagccgt gcctccaggg     3840

tgaggcagag agcaaggcct ctaagctctt tggcaactac tcccgggatc agcccatctt     3900

cctgcggctt gaggattatt tctgggtcaa gacgccatct gcttacgagc tgccctatgg     3960

gaccaagggg agtgaggatc tgctcctccg ggtgctagcc atcaccagct cctccatccc     4020

caagaacatc cagagcctca ggtgccgccg ctgtgtggtc gtggggaacg ggcaccggct     4080

gcggaacagc tcactgggag atgccatcaa caagtacgat gtggtcatca gattgaacaa     4140

tgccccagtg gctggctatg agggtgacgt gggctccaag accaccatgc gtctcttcta     4200

ccctgaatct gcccacttcg accccaaagt agaaaacaac ccagacacac tcctcgtcct     4260

ggtagctttc aaggcaatgg acttccactg gattgagacc atcctgagtg ataagaagcg     4320

ggtgcgaaag ggtttctgga aacagcctcc cctcatctgg gatgtcaatc ctaaacagat     4380

tcggattctc aaccccttct tcatggagat tgcagctgac aaactgctga gcctgccaat     4440

gcaacagcca cggaagatta agcagaagcc caccacgggc ctgttggcca tcacgctggc     4500

cctccacctc tgtgacttgg tgcacattgc cggctttggc tacccagacg cctacaacaa     4560

gaagcagacc attcactact atgagcagat cacgctcaag tccatggcgg ggtcaggcca     4620

taatgtctcc caagaggccc tggccattaa gcggatgctg gagatgggag ctatcaagaa     4680

cctcacgtcc ttctgacaac tttattatac atagttgatc ctcaggtgca ggctgcctat     4740

cagaaggtgg tggctggtgt ggccaatgcc ctggctcaca aataccactg agatcttttt     4800

ccctctgcca aaaattatgg ggacatcatg aagccccttg agcatctgac ttctggctaa     4860

taaaggaaat ttattttcat tgcaatagtg tgttggaatt ttttgtgtct ctcactcgga     4920

aggacatatg ggagggcaaa tcatttaaaa catcagaatg agtatttggt ttagagtttg     4980

gcaacatatg cccatatgct ggctgccatg aacaaaggtt ggctataaag aggtcatcag     5040

tatatgaaac agccccctgc tgtccattcc ttattccata gaaaagcctt gacttgaggt     5100

tagatttttt ttatattttg ttttgtgtta tttttttctt taacatccct aaaattttcc     5160

ttacatgttt tactagccag atttttcctc ctctcctgac tactcccagt catagctgtc     5220

cctcttctct tatggagatc cctcgacctg cagcccaagc ttcgcgttga cattgattat     5280

tgactagtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt     5340

tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc     5400

cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac     5460

gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata     5520

tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc     5580

agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta     5640

ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac     5700

ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc     5760

aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc     5820

gtgtacggtg ggaggtctat ataagcagag ctctctggct aactagagaa cccactgcgc     5880

caccatggtg agcaagggcg aggagctgtt caccggggtg gtgcccatcc tggtcgagct     5940

ggacggcgac gtaaacggcc acaagttcag cgtgtccggc gagggcgagg gcgatgccac     6000

ctacggcaag ctgaccctga agttcatctg caccaccggc aagctgcccg tgccctggcc     6060

caccctcgtg accaccctga cctacggcgt gcagtgcttc agccgctacc ccgaccacat     6120

gaagcagcac gacttcttca agtccgccat gcccgaaggc tacgtccagg agcgcaccat     6180

cttcttcaag gacgacggca actacaagac ccgcgccgag gtgaagttcg agggcgacac     6240

cctggtgaac cgcatcgagc tgaagggcat cgacttcaag gaggacggca acatcctggg     6300

gcacaagctg gagtacaact acaacagcca caacgtctat atcatggccg acaagcagaa     6360

gaacggcatc aaggtgaact tcaagatccg ccacaacatc gaggacggca gcgtgcagct     6420

cgccgaccac taccagcaga acacccccat cggcgacggc cccgtgctgc tgcccgacaa     6480

ccactacctg agcacccagt ccgccctgag caaagacccc aacgagaagc gcgatcacat     6540

ggtcctgctg gagttcgtga ccgccgccgg gatcactctc ggcatggacg agctgtacaa     6600

gatgaccgag tacaagccca cggtgcgcct cgccacccgc gacgacgtcc ccagggccgt     6660

acgcaccctc gccgccgcgt tcgccgacta ccccgccacg cgccacaccg tcgatccgga     6720

ccgccacatc gagcgggtca ccgagctgca agaactcttc ctcacgcgcg tcgggctcga     6780

catcggcaag gtgtgggtcg cggacgacgg cgccgcggtg gcggtctgga ccacgccgga     6840

gagcgtcgaa gcgggggcgg tgttcgccga gatcggcccg cgcatggccg agttgagcgg     6900

ttcccggctg gccgcgcagc aacagatgga aggcctcctg gcgccgcacc ggcccaagga     6960

gcccgcgtgg ttcctggcca ccgtcggcgt ctcgcccgac caccagggca agggtctggg     7020

cagcgccgtc gtgctccccg gagtggaggc ggccgagcgc gccggggtgc ccgccttcct     7080

ggagacctcc gcgccccgca acctcccctt ctacgagcgg ctcggcttca ccgtcaccgc     7140

cgacgtcgag gtgcccgaag gaccgcgcac ctggtgcatg acccgcaagc ccggtgcctg     7200

actcgagtct agagggcccg tttaaacccg ctgatcagcc tcgactgtgc cttctagttg     7260

ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc     7320

cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc     7380

tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag     7440

gcatgctggg gatgcggtgg gctctatggt ggctcgagtt aattaacgag agcataatat     7500

tgatatgtgc caaagttgtt tctgactgac taataagtat aatttgtttc tattatgtat     7560

aggttaagct aattacttat tttataatac aacatgactg tttttaaagt acaaaataag     7620

tttatttttg taaaagagag aatgtttaaa agttttgtta ctttatagaa gaaattttga     7680

gtttttgttt ttttttaata aataaataaa cataaataaa ttgtttgttg aatttattat     7740

tagtatgtaa gtgtaaatat aataaaactt aatatctatt caaattaata aataaacctc     7800

gatatacaga ccgataaaac acatgcgtca attttacgca tgattatctt taacgtacgt     7860

cacaatatga ttatctttct agggttaa                                        7888


<210> 21
<211> 36
<212> PRT
<213> Homo sapiens

<400> 21
Met Gly Pro Arg Gly Ala Ala Ser Leu Pro Arg Gly Pro Gly Pro Arg 
1               5                   10                  15      


Arg Leu Leu Leu Pro Val Val Leu Pro Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Ala Pro Pro Gly 
        35      


<210> 22
<211> 108
<212> DNA
<213> Homo sapiens

<400> 22
atgggtccgc gcggcgcggc gagcttgccc cgaggccccg gacctcggcg gctgctcctc       60

cccgtcgtcc tcccgctgct gctgctgctg ttgttggcgc cgccgggc                   108


<210> 23
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 24
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Arg Gly Asp Ser Pro 
1               5   


<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Gly Gly Gly Arg Gly Asp Ser Pro 
1               5  


<210> 26
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Gly Arg Gly Asp 
1               


<210> 27
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Gly Arg Gly Asp Ser Pro 
1               5       


<210> 28
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Gly Gly Arg Gly Asp Ser Pro 
1               5           


