                         SEQUENCE LISTING

<110>  Katharsis Technologies Inc.
 
<120>  SENSOR SYSTEMS FOR DETECTION OF VIRUS PARTICLES

<130>  P5275PC00

<150>  US 63147317
<151>  2021-02-09

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Arg Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  2
<211>  805
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Thr 
1               5                   10                  15      


Ala Gln Ser Leu Thr Glu Glu Asn Ala Lys Thr Phe Leu Asn Asn Phe 
            20                  25                  30          


Asn Gln Glu Ala Glu Asp Leu Ser Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Ala Gln Lys Met Ser Glu 
    50                  55                  60                  


Ala Ala Ala Lys Trp Ser Ala Phe Tyr Glu Glu Gln Ser Lys Thr Ala 
65                  70                  75                  80  


Gln Ser Phe Ser Leu Gln Glu Ile Gln Thr Pro Ile Ile Lys Arg Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Ser Gly Ser Ser Ala Leu Ser Ala Asp Lys 
            100                 105                 110         


Asn Lys Gln Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Lys Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asp Glu Ile Met Ala Thr Ser Thr Asp Tyr Asn Ser 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Gly Trp Arg Ala Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn Asn Tyr Asn Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Ala Glu Gly Ala Asp Gly Tyr Asn Tyr Asn Arg Asn Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu Arg Thr Phe Ala Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Arg Lys Leu Met Asp Thr Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Thr Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Pro Leu Thr Val Pro Phe Ala Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Met Asn Gln Gly Trp Asp Ala 
    290                 295                 300                 


Glu Arg Ile Phe Gln Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro His Met Thr Gln Gly Phe Trp Ala Asn Ser Met Leu Thr Glu Pro 
                325                 330                 335     


Ala Asp Gly Arg Lys Val Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


His Gly Asp Phe Arg Ile Lys Met Cys Thr Lys Val Thr Met Asp Asn 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Arg Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Pro Ser Asp Phe Gln Glu Asp Ser 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Arg Gly Glu Ile Pro Lys Glu Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Leu Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Ile Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys Tyr Asn Gly Ser Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Leu Lys Met Leu Ser Leu 
545                 550                 555                 560 


Gly Asn Ser Glu Pro Trp Thr Lys Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Arg Asn Met Asp Val Lys Pro Leu Leu Asn Tyr Phe Gln Pro Leu Phe 
            580                 585                 590         


Asp Trp Leu Lys Glu Gln Asn Arg Asn Ser Phe Val Gly Trp Asn Thr 
        595                 600                 605             


Glu Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Ala Asn Ala Tyr Glu Trp Thr Asn Asn Glu Met 
625                 630                 635                 640 


Phe Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Lys Tyr Phe Ser 
                645                 650                 655     


Ile Ile Lys Asn Gln Thr Val Pro Phe Leu Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ser Asp Leu Lys Pro Arg Val Ser Phe Tyr Phe Phe Val Thr Ser Pro 
        675                 680                 685             


Gln Asn Val Ser Asp Val Ile Pro Arg Ser Glu Val Glu Asp Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Gly Arg Ile Asn Asp Val Phe Gly Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile His Pro Thr Leu Glu Pro Pro Tyr Gln 
                725                 730                 735     


Pro Pro Val Thr Ile Trp Leu Ile Ile Phe Gly Val Val Met Ala Leu 
            740                 745                 750         


Val Val Val Gly Ile Ile Ile Leu Ile Val Thr Gly Ile Lys Gly Arg 
        755                 760                 765             


Lys Lys Lys Asn Glu Thr Lys Arg Glu Glu Asn Pro Tyr Asp Ser Met 
    770                 775                 780                 


Asp Ile Gly Lys Gly Glu Ser Asn Ala Gly Phe Gln Asn Ser Asp Asp 
785                 790                 795                 800 


Ala Gln Thr Ser Phe 
                805 


<210>  3
<211>  805
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Thr 
1               5                   10                  15      


Ala Gln Ser Leu Thr Glu Glu Asn Ala Lys Thr Phe Leu Asn Asn Phe 
            20                  25                  30          


Asn Gln Glu Ala Glu Asp Leu Ser Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Ala Gln Lys Met Ser Glu 
    50                  55                  60                  


Ala Ala Ala Lys Trp Ser Ala Phe Tyr Glu Glu Gln Ser Lys Thr Ala 
65                  70                  75                  80  


Gln Ser Phe Ser Leu Gln Glu Ile Gln Thr Pro Ile Ile Lys Arg Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Ser Gly Ser Ser Ala Leu Ser Ala Asp Lys 
            100                 105                 110         


Asn Lys Gln Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Lys Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asp Glu Ile Met Ala Thr Ser Thr Asp Tyr Asn Ser 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Gly Trp Arg Ala Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn Asn Tyr Asn Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Ala Glu Gly Ala Asp Gly Tyr Asn Tyr Asn Arg Asn Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu Arg Thr Phe Ala Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Arg Lys Leu Met Asp Thr Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Thr Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Pro Leu Thr Val Pro Phe Ala Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Met Asn Gln Gly Trp Asp Ala 
    290                 295                 300                 


Glu Arg Ile Phe Gln Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro His Met Thr Gln Gly Phe Trp Ala Asn Ser Met Leu Thr Glu Pro 
                325                 330                 335     


Ala Asp Gly Arg Lys Val Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


His Gly Asp Phe Arg Ile Lys Met Cys Thr Lys Val Thr Met Asp Asn 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Arg Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Pro Ser Asp Phe Gln Glu Asp Ser 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Arg Gly Glu Ile Pro Lys Glu Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Leu Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Ile Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys Tyr Asn Gly Ser Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Leu Lys Met Leu Ser Leu 
545                 550                 555                 560 


Gly Asn Ser Glu Pro Trp Thr Lys Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Arg Asn Met Asp Val Lys Pro Leu Leu Asn Tyr Phe Gln Pro Leu Phe 
            580                 585                 590         


Asp Trp Leu Lys Glu Gln Asn Arg Asn Ser Phe Val Gly Trp Asn Thr 
        595                 600                 605             


Glu Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Ala Asn Ala Tyr Glu Trp Thr Asn Asn Glu Met 
625                 630                 635                 640 


Phe Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Lys Tyr Phe Ser 
                645                 650                 655     


Ile Ile Lys Asn Gln Thr Val Pro Phe Leu Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ser Asp Leu Lys Pro Arg Val Ser Phe Tyr Phe Phe Val Thr Ser Pro 
        675                 680                 685             


Gln Asn Val Ser Asp Val Ile Pro Arg Ser Glu Val Glu Asp Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Gly Arg Ile Asn Asp Val Phe Gly Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile His Pro Thr Leu Glu Pro Pro Tyr Gln 
                725                 730                 735     


Pro Pro Val Thr Ile Trp Leu Ile Ile Phe Gly Val Val Met Ala Leu 
            740                 745                 750         


Val Val Val Gly Ile Ile Ile Leu Ile Val Thr Gly Ile Lys Gly Arg 
        755                 760                 765             


Lys Lys Lys Asn Glu Thr Lys Arg Glu Glu Asn Pro Tyr Asp Ser Met 
    770                 775                 780                 


Asp Ile Gly Lys Gly Glu Ser Asn Ala Gly Phe Gln Asn Ser Asp Asp 
785                 790                 795                 800 


Ala Gln Thr Ser Phe 
                805 


<210>  4
<211>  805
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Met Ser Ser Ser Cys Trp Leu Leu Leu Ser Leu Val Ala Val Ala Thr 
1               5                   10                  15      


Ala Gln Ser Leu Ile Glu Glu Lys Ala Glu Ser Phe Leu Asn Lys Phe 
            20                  25                  30          


Asn Gln Glu Ala Glu Asp Leu Ser Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Ala Gln Lys Met Asn Glu 
    50                  55                  60                  


Ala Ala Ala Lys Trp Ser Ala Phe Tyr Glu Glu Gln Ser Lys Ile Ala 
65                  70                  75                  80  


Gln Asn Phe Ser Leu Gln Glu Ile Gln Asn Ala Thr Ile Lys Arg Gln 
                85                  90                  95      


Leu Lys Ala Leu Gln Gln Ser Gly Ser Ser Ala Leu Ser Pro Asp Lys 
            100                 105                 110         


Asn Lys Gln Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Ser Met Asn Pro Gln Glu Cys Phe Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asp Glu Ile Met Ala Thr Ser Thr Asp Tyr Asn Arg 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Gly Trp Arg Ala Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn Asn Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Ala Glu Gly Val Glu Gly Tyr Asn Tyr Asn Arg Asn Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu Asn Thr Phe Lys Glu Ile Lys Pro Leu Tyr Glu Gln Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Thr Lys Leu Met Glu Val Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Thr Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Pro Leu Thr Thr Pro Phe Leu Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asn Gln Ser Trp Asp Ala 
    290                 295                 300                 


Glu Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Gln Met Thr Pro Gly Phe Trp Thr Asn Ser Met Leu Thr Glu Pro 
                325                 330                 335     


Gly Asp Asp Arg Lys Val Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


His Gly Asp Phe Arg Ile Lys Met Cys Thr Lys Val Thr Met Asp Asn 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Lys Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Pro Ser Asn Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Gln Asp Lys Ile Pro Arg Glu Gln Trp Thr Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Leu Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Ile Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Asp Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Leu Asn Met Leu Ser Leu 
545                 550                 555                 560 


Gly Asn Ser Gly Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ser 
                565                 570                 575     


Arg Asn Met Asp Val Lys Pro Leu Leu Asn Tyr Phe Gln Pro Leu Phe 
            580                 585                 590         


Val Trp Leu Lys Glu Gln Asn Arg Asn Ser Thr Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Lys Asn Ala Tyr Glu Trp Thr Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Glu Tyr Phe Ser 
                645                 650                 655     


Arg Glu Lys Asn Gln Thr Val Pro Phe Gly Glu Ala Asp Val Trp Val 
            660                 665                 670         


Ser Asp Leu Lys Pro Arg Val Ser Phe Asn Phe Phe Val Thr Ser Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Ser Glu Val Glu Glu Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Gly Arg Ile Asn Asp Ile Phe Gly Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Tyr Pro Thr Leu Lys Pro Pro Tyr Glu 
                725                 730                 735     


Pro Pro Val Thr Ile Trp Leu Ile Ile Phe Gly Val Val Met Gly Thr 
            740                 745                 750         


Val Val Val Gly Ile Val Ile Leu Ile Val Thr Gly Ile Lys Gly Arg 
        755                 760                 765             


Lys Lys Lys Asn Glu Thr Lys Arg Glu Glu Asn Pro Tyr Asp Ser Met 
    770                 775                 780                 


Asp Ile Gly Lys Gly Glu Ser Asn Ala Gly Phe Gln Asn Ser Asp Asp 
785                 790                 795                 800 


Ala Gln Thr Ser Phe 
                805 


<210>  5
<211>  805
<212>  PRT
<213>  Sus scrofa

<400>  5

Met Ser Gly Ser Phe Trp Leu Leu Leu Ser Leu Ile Pro Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Thr Glu Glu Leu Ala Lys Thr Phe Leu Glu Lys Phe 
            20                  25                  30          


Asn Leu Glu Ala Glu Asp Leu Ala Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Thr Ile Asn Thr Asn Ile Thr Asp Glu Asn Ile Gln Lys Met Asn Asp 
    50                  55                  60                  


Ala Arg Ala Lys Trp Ser Ala Phe Tyr Glu Glu Gln Ser Arg Ile Ala 
65                  70                  75                  80  


Lys Thr Tyr Pro Leu Asp Glu Ile Gln Thr Leu Ile Leu Lys Arg Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Ser Gly Thr Ser Gly Leu Ser Ala Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Ser Gly Lys Val Leu Asp Pro Asn Asn Pro Gln Glu Cys Leu Val Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asp Glu Ile Met Glu Asn Ser Lys Asp Tyr Ser Arg 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ala Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Glu Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn Asn Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Thr Gly Thr Gly Asp Tyr Asp Tyr Ser Arg Asn Gln Leu Met Glu 
    210                 215                 220                 


Asp Val Glu Arg Thr Phe Ala Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asp Ala Tyr Pro Ser Arg Ile 
                245                 250                 255     


Ser Pro Thr Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Pro Leu Thr Val Pro Phe Gly Glu Lys 
        275                 280                 285             


Pro Ser Ile Asp Val Thr Glu Ala Met Val Asn Gln Ser Trp Asp Ala 
    290                 295                 300                 


Ile Arg Ile Phe Glu Glu Ala Glu Lys Phe Phe Val Ser Ile Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Asn Asn Ser Met Leu Thr Glu Pro 
                325                 330                 335     


Gly Asp Gly Arg Lys Val Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Lys Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ile Gln Pro Tyr Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro His 
                405                 410                 415     


Tyr Leu Lys Ala Leu Gly Leu Leu Pro Pro Asp Phe Tyr Glu Asp Ser 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Glu Gln Trp Met Gln Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Leu Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Cys Leu Phe His Val Ala Glu Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Ile Tyr Gln Phe Gln Phe His Glu Ala 
        515                 520                 525             


Leu Cys Arg Thr Ala Lys His Glu Gly Pro Leu Tyr Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Leu Gln Met Leu Ser Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Ile Val Gly Val 
                565                 570                 575     


Lys Thr Met Asp Val Lys Pro Leu Leu Ser Tyr Phe Glu Pro Leu Leu 
            580                 585                 590         


Thr Trp Leu Lys Ala Gln Asn Gly Asn Ser Ser Val Gly Trp Asn Thr 
        595                 600                 605             


Asp Trp Thr Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Glu Asp Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Ile Ala Tyr Ala Met Arg Asn Tyr Phe Ser 
                645                 650                 655     


Ser Ala Lys Asn Glu Thr Ile Pro Phe Gly Ala Val Asp Val Trp Val 
            660                 665                 670         


Ser Asp Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ser Pro 
        675                 680                 685             


Ala Asn Met Ser Asp Ile Ile Pro Arg Ser Asp Val Glu Lys Ala Ile 
    690                 695                 700                 


Ser Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asp Asp Asn 
705                 710                 715                 720 


Thr Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asp Glu 
                725                 730                 735     


Pro Pro Val Thr Val Trp Leu Ile Ile Phe Gly Val Val Met Gly Leu 
            740                 745                 750         


Val Val Val Gly Ile Val Val Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Arg Lys Lys Lys Gln Ala Ser Ser Glu Glu Asn Pro Tyr Gly Ser Met 
    770                 775                 780                 


Asp Leu Ser Lys Gly Glu Ser Asn Ser Gly Phe Gln Asn Gly Asp Asp 
785                 790                 795                 800 


Ile Gln Thr Ser Phe 
                805 


<210>  6
<211>  808
<212>  PRT
<213>  Gallus gallus

<400>  6

Met Leu Leu His Phe Trp Leu Leu Cys Gly Leu Ser Ala Val Val Thr 
1               5                   10                  15      


Pro Gln Asp Val Thr Gln Glu Ala Gln Thr Phe Leu Ala Glu Phe Asn 
            20                  25                  30          


Val Arg Ala Glu Asp Ile Ser Tyr Glu Asn Ser Leu Ala Ser Trp Asn 
        35                  40                  45              


Tyr Asn Thr Asn Ile Thr Glu Glu Thr Ala Arg Lys Met Ser Glu Ala 
    50                  55                  60                  


Gly Ala Lys Trp Ala Ala Phe Tyr Glu Glu Ala Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Arg Phe Ser Leu Ala Asn Ile Gln Asp Ala Val Thr Arg Leu Gln Ile 
                85                  90                  95      


Gln Ser Leu Gln Asp Arg Gly Ser Ser Val Leu Ser Pro Glu Lys Tyr 
            100                 105                 110         


Ser Arg Leu Asn Ser Val Met Asn Ser Met Ser Thr Ile Tyr Ser Thr 
        115                 120                 125             


Gly Val Val Cys Lys Ala Thr Glu Pro Phe Asp Cys Leu Val Leu Glu 
    130                 135                 140                 


Pro Gly Leu Asp Asp Ile Met Ala Asn Ser Ile Asp Tyr His Glu Arg 
145                 150                 155                 160 


Leu Trp Ala Trp Glu Gly Trp Arg Ala Asp Val Gly Arg Met Met Arg 
                165                 170                 175     


Pro Leu Tyr Glu Glu Tyr Val Glu Leu Lys Asn Glu Ala Ala Arg Leu 
            180                 185                 190         


Asn Asn Tyr Ser Asp Tyr Gly Asp Tyr Trp Arg Ala Asn Tyr Glu Thr 
        195                 200                 205             


Asp Tyr Pro Glu Glu Tyr Lys Tyr Ser Arg Asp Gln Leu Val Gln Asp 
    210                 215                 220                 


Val Glu Lys Thr Phe Glu Gln Ile Lys Pro Leu Tyr Gln His Leu His 
225                 230                 235                 240 


Ala Tyr Val Arg His Arg Leu Glu Gln Val Tyr Gly Ser Glu Leu Ile 
                245                 250                 255     


Asn Pro Thr Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Asn Leu Thr Val Pro Tyr Pro Glu Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Ser Ala Met Ala Gln Lys Asn Trp Asp Ala 
    290                 295                 300                 


Met Lys Ile Phe Lys Thr Ala Glu Ala Phe Phe Ala Ser Ile Gly Leu 
305                 310                 315                 320 


Tyr Asn Met Thr Glu Gly Phe Trp Thr Asn Ser Met Leu Thr Glu Pro 
                325                 330                 335     


Thr Asp Asn Arg Lys Val Val Cys His Pro Thr Ala Trp Asp Met Gly 
            340                 345                 350         


Lys Asn Asp Tyr Arg Ile Lys Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Glu Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ser Val Gln Pro Phe Leu Leu Arg Asp Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Gln 
                405                 410                 415     


His Leu Lys Ser Leu Asp Leu Leu Glu Pro Thr Phe Gln Glu Asp Glu 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Met Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Asn Gly Glu Ile Thr Lys Gln Glu Trp Thr Lys Arg Trp Trp Lys Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ala Leu Phe His Val Ala Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Ile Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Lys Ala Ala Asn His Thr Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Thr Asn Ser Thr Ala Ala Gly Gly Asn Leu Arg Gln Leu Leu Glu Leu 
545                 550                 555                 560 


Gly Lys Ser Lys Pro Trp Thr Gln Ala Leu Glu Ser Ala Thr Gly Glu 
                565                 570                 575     


Lys Tyr Met Asn Ala Thr Pro Leu Leu His Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Asn Trp Leu Gln Lys Asn Asn Ser Gly Arg Ser Ile Gly Trp Asn Thr 
        595                 600                 605             


Asp Trp Thr Pro Tyr Ser Asp Asn Ala Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ala Ala Leu Gly Asp Asp Ala Tyr Val Trp Asp Ala Ser Glu Leu 
625                 630                 635                 640 


Phe Leu Phe Lys Ser Ser Ile Ala Tyr Ala Met Arg Lys Tyr Phe Ala 
                645                 650                 655     


Lys Glu Lys Glu Gln Asn Val Asp Phe Gln Val Thr Asp Ile His Val 
            660                 665                 670         


Gly Glu Glu Thr Gln Arg Val Ser Phe Tyr Leu Thr Val Ser Met Pro 
        675                 680                 685             


Gly Asn Val Ser Asp Ile Val Pro Arg Ala Asp Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Gly Arg Ile Ser Glu Ala Phe Arg Leu Asp Asp Asn 
705                 710                 715                 720 


Thr Leu Glu Phe Asp Gly Ile Val Pro Thr Leu Ala Thr Pro Tyr Lys 
                725                 730                 735     


Pro Pro Val Thr Ile Trp Leu Ile Leu Phe Gly Val Val Met Ser Leu 
            740                 745                 750         


Ile Val Ile Gly Val Ile Val Leu Ile Ile Thr Gly Gln Arg Asp Lys 
        755                 760                 765             


Arg Lys Lys Ala Arg Gly Arg Ala Asn Glu Ala Gly Ser Asn Cys Glu 
    770                 775                 780                 


Val Asn Pro Tyr Asp Glu Asp Gly Arg Ser Asn Lys Gly Phe Glu Gln 
785                 790                 795                 800 


Ser Glu Glu Thr Gln Thr Ser Phe 
                805             


<210>  7
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Receptor Binding Domain of SARS-CoV-2

<400>  7

Leu Glu Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
1               5                   10                  15      


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
            20                  25                  30          


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
        35                  40                  45              


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
    50                  55                  60                  


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
65                  70                  75                  80  


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
                85                  90                  95      


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
            100                 105                 110         


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
        115                 120                 125             


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
    130                 135                 140                 


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
145                 150                 155                 160 


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
                165                 170                 175     


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
            180                 185                 190         


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
        195                 200                 205             


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
    210                 215                 220                 


Phe 
225 


<210>  8
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2

<400>  8

Met Glu Ile Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Leu Glu Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
            20                  25                  30          


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
        35                  40                  45              


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
    50                  55                  60                  


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
65                  70                  75                  80  


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
                85                  90                  95      


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
            100                 105                 110         


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
        115                 120                 125             


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
    130                 135                 140                 


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
145                 150                 155                 160 


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
                165                 170                 175     


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
            180                 185                 190         


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
        195                 200                 205             


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
    210                 215                 220                 


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
225                 230                 235                 240 


Asn Phe Gly Ser Gly His His His His His His 
                245                 250     


<210>  9
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2

<220>
<223>  Homo sapiens

<400>  9

Met Glu Ile Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Lys Pro Thr Glu Leu Glu Arg Val Gln Pro Thr Glu Ser Ile Val 
            20                  25                  30          


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
        35                  40                  45              


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
    50                  55                  60                  


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
65                  70                  75                  80  


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
                85                  90                  95      


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
            100                 105                 110         


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
        115                 120                 125             


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
    130                 135                 140                 


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
145                 150                 155                 160 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
                165                 170                 175     


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
            180                 185                 190         


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
        195                 200                 205             


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
    210                 215                 220                 


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
225                 230                 235                 240 


Asn Lys Cys Val Asn Phe Arg Thr Glu Asn Leu Tyr Phe Gln Gly Ser 
                245                 250                 255     


Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
            260                 265                 270         


Pro Ala Pro Glu Ala Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        355                 360                 365             


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
385                 390                 395                 400 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490 


<210>  10
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens

<400>  10

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser 
            740 


<210>  11
<211>  984
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens

<400>  11

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Arg Thr Glu Asn Leu Tyr Phe Gln Gly Ser Gly Ser 
            740                 745                 750         


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        755                 760                 765             


Pro Glu Ala Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    770                 775                 780                 


Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
785                 790                 795                 800 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                805                 810                 815     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            820                 825                 830         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        835                 840                 845             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    850                 855                 860                 


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
865                 870                 875                 880 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                885                 890                 895     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            900                 905                 910         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        915                 920                 925             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    930                 935                 940                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
945                 950                 955                 960 


Ser Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                965                 970                 975     


Ser Leu Ser Leu Ser Pro Gly Lys 
            980                 


