                         б
<110>  ݴѧڶҽԺ
       ݻƼι˾
 
<120>  CD87弰ǶϿԭ
<130>  SH.1
<160>  23    
<170>  PatentIn version 3.5

<210>  1
<211>  1416
<212>  DNA
<213>  ˹
<220>
<223>  Anti-PLAUR-A7-H
<400>  1
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60
gacgaggtgc agctgcagga gtctggggct gaacttgtga agcctggggc ttcagtaaag      120
atgtcctgta aggcttctgg gtacaccttc accagctact ggataacctg ggtgaagcag      180
aggcctggac aaggccttga gtggattgga aatatttatc ctggtagtgg tagtactaac      240
tataatgaga agttcaagag caaggccaca ctgactgtag acacatcgtc ccgcacagcc      300
tacatgcagc tcagcagcct gacatctgag gactctgcgg tctatcactg tgcaagagag      360
ggggcgtggg ggacctatgc tatggactac tggggtcaag ggacctctct caccgtctcc      420
tcagctaaga caacagctcc atcggtctat ccactggccc ctgtgtgtgg agatacaact      480
ggctcctcgg tgactctagg atgcctggtc aagggttatt tccctgagcc agtgaccttg      540
acctggaact ctggatccct gtccagtggt gtgcacacct tcccagctgt cctgcagtct      600
gacctctaca ccctcagcag ctcagtgact gtaacctcga gcacctggcc cagccagtcc      660
atcacctgca atgtggccca cccggcaagc agcaccaagg tggacaagaa aattgagccc      720
agagggccca caatcaagcc ctgtcctcca tgcaaatgcc cagcacctaa cctcttgggt      780
ggaccatccg tcttcatctt ccctccaaag atcaaggatg tactcatgat ctccctgagc      840
cccatagtca catgtgtggt ggtggatgtg agcgaggatg acccagatgt ccagatcagc      900
tggtttgtga acaacgtgga agtacacaca gctcagacac aaacccatag agaggattac      960
aacagtactc tccgggtggt cagtgccctc cccatccagc accaggactg gatgagtggc     1020
aaggagttca aatgcaaggt caacaacaaa gacctcccag cgcccatcga gagaaccatc     1080
tcaaaaccca aagggtcagt aagagctcca caggtatatg tcttgcctcc accagaagaa     1140
gagatgacta agaaacaggt cactctgacc tgcatggtca cagacttcat gcctgaagac     1200
atttacgtgg agtggaccaa caacgggaaa acagagctaa actacaagaa cactgaacca     1260
gtcctggact ctgatggttc ttacttcatg tacagcaagc tgagagtgga aaagaagaac     1320
tgggtggaaa gaaatagcta ctcctgttca gtggtccacg agggtctgca caatcaccac     1380
acgactaaga gcttctcccg gactccgggt aaatga                               1416

<210>  2
<211>  471
<212>  PRT
<213>  ˹
<220>
<223>  Anti-PLAUR-A7-H
<400>  2
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      

Gly Ser Thr Gly Asp Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu 
            20                  25                  30          

Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              

Thr Phe Thr Ser Tyr Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  

Gly Leu Glu Trp Ile Gly Asn Ile Tyr Pro Gly Ser Gly Ser Thr Asn 
65                  70                  75                  80  

Tyr Asn Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser 
                85                  90                  95      

Ser Arg Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         

Ala Val Tyr His Cys Ala Arg Glu Gly Ala Trp Gly Thr Tyr Ala Met 
        115                 120                 125             

Asp Tyr Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser Ala Lys Thr 
    130                 135                 140                 

Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr 
145                 150                 155                 160 

Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
                165                 170                 175     

Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
            180                 185                 190         

Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
        195                 200                 205             

Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn 
    210                 215                 220                 

Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro 
225                 230                 235                 240 

Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
                245                 250                 255     

Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
            260                 265                 270         

Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
        275                 280                 285             

Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
    290                 295                 300                 

Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
305                 310                 315                 320 

Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
                325                 330                 335     

Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
            340                 345                 350         

Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
        355                 360                 365             

Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
    370                 375                 380                 

Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
385                 390                 395                 400 

Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
                405                 410                 415     

Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
            420                 425                 430         

Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
        435                 440                 445             

Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
    450                 455                 460                 

Phe Ser Arg Thr Pro Gly Lys 
465                 470     

<210>  3
<211>  708
<212>  DNA
<213>  ˹
<220>
<223>  Anti-PLAUR-A7-L
<400>  3
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60
gacgatattg tgatgaccca gtctccaaaa ttcatgtcca catcagtagg agacagggtc      120
agcgtcacct gcaaggccag tcagaatgtg ggtggtcatg tagcctggta tcaacagaaa      180
ccagggctct ctcctaaagc actgatttac tcggcatcct accggtacag tggagtccct      240
gatcgcttca caggcagtgg atctgggaca gatttcactc tcaccatcag caatgtgcag      300
tctgaagact tggcagagta tttctgtcag caatataaca cctatccgtg gacgttcggt      360
ggggggacca agctggaaat caaacgggca gatgctgcac caactgtatc catcttccca      420
ccatccagtg agcagttaac atctggaggt gcctcagtcg tgtgcttctt gaacaacttc      480
taccccaaag acatcaatgt caagtggaag attgatggca gtgaacgaca aaatggcgtc      540
ctgaacagtt ggactgatca ggacagcaaa gacagcacct acagcatgag cagcaccctc      600
acgttgacca aggacgagta tgaacgacat aacagctata cctgtgaggc cactcacaag      660
acatcaactt cacccattgt caagagcttc aacaggaatg agtgttag                   708

<210>  4
<211>  235
<212>  PRT
<213>  ˹
<220>
<223>  Anti-PLAUR-A7-L
<400>  4
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      

Gly Ser Thr Gly Asp Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met 
            20                  25                  30          

Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln 
        35                  40                  45              

Asn Val Gly Gly His Val Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ser 
    50                  55                  60                  

Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro 
65                  70                  75                  80  

Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      

Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr 
            100                 105                 110         

Asn Thr Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 

Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
145                 150                 155                 160 

Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
                165                 170                 175     

Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
            180                 185                 190         

Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
        195                 200                 205             

Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
    210                 215                 220                 

Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235 

<210>  5
<211>  1428
<212>  DNA
<213>  ˹
<220>
<223>  Anti-PLAUR-E2-H
<400>  5
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60
gacgaggtgc agctgcagga gtctggggtt gaaccggtga agcctggggc ctcagtgaag      120
atttcctgca aagcttctgg ctatgcattc agtaactact ggatgaactg ggtgaagcag      180
aggcctggaa agggtcttga gtggattgga cagatttatc ctggagatgg tgatactaac      240
tacaatagaa aattcaagga cagggcctca ctgactgcag acaaatcctc cagcacagcc      300
tacatgcagt tcagcagcct ggcctctgaa gactctgcgg tctatttctg tgcaagaagc      360
cccctctatg atagtgaccc cccttactct agtatggact actggggtca agggaccaca      420
ctcaccgtct cctcggctaa gacaacagct ccatcggtct atccactggc ccctgtgtgt      480
ggagatacaa ctggctcctc ggtgactcta ggatgcctgg tcaagggtta tttccctgag      540
ccagtgacct tgacctggaa ctctggatcc ctgtccagtg gtgtgcacac cttcccagct      600
gtcctgcagt ctgacctcta caccctcagc agctcagtga ctgtaacctc gagcacctgg      660
cccagccagt ccatcacctg caatgtggcc cacccggcaa gcagcaccaa ggtggacaag      720
aaaattgagc ccagagggcc cacaatcaag ccctgtcctc catgcaaatg cccagcacct      780
aacctcttgg gtggaccatc cgtcttcatc ttccctccaa agatcaagga tgtactcatg      840
atctccctga gccccatagt cacatgtgtg gtggtggatg tgagcgagga tgacccagat      900
gtccagatca gctggtttgt gaacaacgtg gaagtacaca cagctcagac acaaacccat      960
agagaggatt acaacagtac tctccgggtg gtcagtgccc tccccatcca gcaccaggac     1020
tggatgagtg gcaaggagtt caaatgcaag gtcaacaaca aagacctccc agcgcccatc     1080
gagagaacca tctcaaaacc caaagggtca gtaagagctc cacaggtata tgtcttgcct     1140
ccaccagaag aagagatgac taagaaacag gtcactctga cctgcatggt cacagacttc     1200
atgcctgaag acatttacgt ggagtggacc aacaacggga aaacagagct aaactacaag     1260
aacactgaac cagtcctgga ctctgatggt tcttacttca tgtacagcaa gctgagagtg     1320
gaaaagaaga actgggtgga aagaaatagc tactcctgtt cagtggtcca cgagggtctg     1380
cacaatcacc acacgactaa gagcttctcc cggactccgg gtaaatga                  1428

<210>  6
<211>  475
<212>  PRT
<213>  ˹
<220>
<223>  Anti-PLAUR-E2-H
<400>  6
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      

Gly Ser Thr Gly Asp Glu Val Gln Leu Gln Glu Ser Gly Val Glu Pro 
            20                  25                  30          

Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              

Ala Phe Ser Asn Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys 
    50                  55                  60                  

Gly Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn 
65                  70                  75                  80  

Tyr Asn Arg Lys Phe Lys Asp Arg Ala Ser Leu Thr Ala Asp Lys Ser 
                85                  90                  95      

Ser Ser Thr Ala Tyr Met Gln Phe Ser Ser Leu Ala Ser Glu Asp Ser 
            100                 105                 110         

Ala Val Tyr Phe Cys Ala Arg Ser Pro Leu Tyr Asp Ser Asp Pro Pro 
        115                 120                 125             

Tyr Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
    130                 135                 140                 

Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys 
145                 150                 155                 160 

Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly 
                165                 170                 175     

Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser 
            180                 185                 190         

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr 
        195                 200                 205             

Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser 
    210                 215                 220                 

Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys 
225                 230                 235                 240 

Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys 
                245                 250                 255     

Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            260                 265                 270         

Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr 
        275                 280                 285             

Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
    290                 295                 300                 

Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
305                 310                 315                 320 

Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
                325                 330                 335     

Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
            340                 345                 350         

Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
        355                 360                 365             

Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 
    370                 375                 380                 

Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe 
385                 390                 395                 400 

Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu 
                405                 410                 415     

Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr 
            420                 425                 430         

Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg 
        435                 440                 445             

Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His 
    450                 455                 460                 

Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470                 475 

<210>  7
<211>  708
<212>  DNA
<213>  ˹
<220>
<223>  Anti-PLAUR-E2-L
<400>  7
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60
gacgatattg tgctcaccca gtctccaaaa ttcatgtcca catcagtagg agacagggtc      120
agcgtcacct gcaaggccag tcagaatgtg ggtcctaatg tggcctggta tcaacagaaa      180
ccaggccaat ctcctaaacc actgatttac tcggcatcct accggtacag tggagtccct      240
gatcgtttca caggcagtaa atctgggaca gatttcactc tcaccatcag caatgtgcag      300
tctgaagact tggcggagta tttctgtcag caatatcaca actatcctct cacgttcggt      360
gctgggacca agctggaaat caaacgggca gatgctgcac caactgtatc catcttccca      420
ccatccagtg agcagttaac atctggaggt gcctcagtcg tgtgcttctt gaacaacttc      480
taccccaaag acatcaatgt caagtggaag attgatggca gtgaacgaca aaatggcgtc      540
ctgaacagtt ggactgatca ggacagcaaa gacagcacct acagcatgag cagcaccctc      600
acgttgacca aggacgagta tgaacgacat aacagctata cctgtgaggc cactcacaag      660
acatcaactt cacccattgt caagagcttc aacaggaatg agtgttag                   708

<210>  8
<211>  235
<212>  PRT
<213>  ˹
<220>
<223>   Anti-PLAUR-E2-L
<400>  8
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      

Gly Ser Thr Gly Asp Asp Ile Val Leu Thr Gln Ser Pro Lys Phe Met 
            20                  25                  30          

Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln 
        35                  40                  45              

Asn Val Gly Pro Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  

Pro Lys Pro Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro 
65                  70                  75                  80  

Asp Arg Phe Thr Gly Ser Lys Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      

Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr 
            100                 105                 110         

His Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 

Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
145                 150                 155                 160 

Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
                165                 170                 175     

Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
            180                 185                 190         

Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
        195                 200                 205             

Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
    210                 215                 220                 

Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235 

<210>  9
<211>  360
<212>  DNA
<213>  ˹
<220>
<223>  Anti-PLAUR-A7-VH
<400>  9
gaggtgcagc tgcaggagtc tggggctgaa cttgtgaagc ctggggcttc agtaaagatg       60
tcctgtaagg cttctgggta caccttcacc agctactgga taacctgggt gaagcagagg      120
cctggacaag gccttgagtg gattggaaat atttatcctg gtagtggtag tactaactat      180
aatgagaagt tcaagagcaa ggccacactg actgtagaca catcgtcccg cacagcctac      240
atgcagctca gcagcctgac atctgaggac tctgcggtct atcactgtgc aagagagggg      300
gcgtggggga cctatgctat ggactactgg ggtcaaggga cctctctcac cgtctcctca      360

<210>  10
<211>  120
<212>  PRT
<213>  ˹
<220>
<223>  Anti-PLAUR-A7-VH
<400>  10
Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          

Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              

Gly Asn Ile Tyr Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  

Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr His Cys 
                85                  90                  95      

Ala Arg Glu Gly Ala Trp Gly Thr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         

Gly Thr Ser Leu Thr Val Ser Ser 
        115                 120 

<210>  11
<211>  324
<212>  DNA
<213>  ˹
<220>
<223>  Anti-PLAUR-A7-VL
<400>  11
gatattgtga tgacccagtc tccaaaattc atgtccacat cagtaggaga cagggtcagc       60
gtcacctgca aggccagtca gaatgtgggt ggtcatgtag cctggtatca acagaaacca      120
gggctctctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180
cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240
gaagacttgg cagagtattt ctgtcagcaa tataacacct atccgtggac gttcggtggg      300
gggaccaagc tggaaatcaa acgg                                             324

<210>  12
<211>  108
<212>  PRT
<213>  ˹
<220>
<223>  Anti-PLAUR-A7-VL
<400>  12
Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Gly His 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ser Pro Lys Ala Leu Ile 
        35                  40                  45              

Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  

Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Thr Tyr Pro Trp 
                85                  90                  95      

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             

<210>  13
<211>  372
<212>  DNA
<213>  ˹
<220>
<223>  Anti-PLAUR-E2-VH
<400>  13
gaggtgcagc tgcaggagtc tggggttgaa ccggtgaagc ctggggcctc agtgaagatt       60
tcctgcaaag cttctggcta tgcattcagt aactactgga tgaactgggt gaagcagagg      120
cctggaaagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac      180
aatagaaaat tcaaggacag ggcctcactg actgcagaca aatcctccag cacagcctac      240
atgcagttca gcagcctggc ctctgaagac tctgcggtct atttctgtgc aagaagcccc      300
ctctatgata gtgacccccc ttactctagt atggactact ggggtcaagg gaccacactc      360
accgtctcct cg                                                          372

<210>  14
<211>  124
<212>  PRT
<213>  ˹
<220>
<223>  Anti-PLAUR-E2-VH
<400>  14
Glu Val Gln Leu Gln Glu Ser Gly Val Glu Pro Val Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr 
            20                  25                  30          

Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              

Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Arg Lys Phe 
    50                  55                  60                  

Lys Asp Arg Ala Ser Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Gln Phe Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      

Ala Arg Ser Pro Leu Tyr Asp Ser Asp Pro Pro Tyr Ser Ser Met Asp 
            100                 105                 110         

Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120                 

<210>  15
<211>  324
<212>  DNA
<213>  ˹
<220>
<223>  Anti-PLAUR-E2-VL
<400>  15
gatattgtgc tcacccagtc tccaaaattc atgtccacat cagtaggaga cagggtcagc       60
gtcacctgca aggccagtca gaatgtgggt cctaatgtgg cctggtatca acagaaacca      120
ggccaatctc ctaaaccact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180
cgtttcacag gcagtaaatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240
gaagacttgg cggagtattt ctgtcagcaa tatcacaact atcctctcac gttcggtgct      300
gggaccaagc tggaaatcaa acgg                                             324

<210>  16
<211>  108
<212>  PRT
<213>  ˹
<220>
<223>  Anti-PLAUR-E2-VL
<400>  16
Asp Ile Val Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Pro Asn 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              

Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  

Ser Lys Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  

Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Asn Tyr Pro Leu 
                85                  90                  95      

Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             

<210>  17
<211>  1178
<212>  DNA
<213>  ˹
<220>
<223>  EF1
<400>  17
gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag aagttgtggg       60
gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg      120
atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat ataagtgcag      180
tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag gtaagtgccg      240
tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg ccttgaatta      300
cttccacctg gctgcagtac gtgattcttg atcccgagct tcgggttgga agtgggtggg      360
agagttcgag gccttgcgct taaggagccc cttcgcctcg tgcttgagtt gaggcctggc      420
ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt      480
tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt tttttctggc      540
aagatagtct tgtaaatgcg ggccaagatc tgcacactgg tatttcggtt tttggggccg      600
cgggcggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag      660
cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg      720
gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg tcggcaccag      780
ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc agggagctca aaatggagga      840
cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg gcctttccgt      900
cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg cacctcgatt      960
agttctcgac cttttggagt acgtcgtctt taggttgggg ggaggggttt tatgcgatgg     1020
agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac ttgatgtaat     1080
tctccttgga atttgccctt tttgagtttg gatcttggtt cattctcaag cctcagacag     1140
tggttcaaag tttttttctt ccatttcagg tgtcgtga                             1178

<210>  18
<211>  60
<212>  DNA
<213>  ˹
<220>
<223>  źIL2-SP
<400>  18
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaactcg       60

<210>  19
<211>  45
<212>  DNA
<213>  ˹
<220>
<223>   GSlinker
<400>  19
ggcggaggcg gaagtggagg cggaggatct ggcggcggag gctct                       45

<210>  20
<211>  135
<212>  DNA
<213>  ˹
<220>
<223>   hCD8a
<400>  20
accactaccc cagcaccgag gccacccacc ccggctccta ccatcgcctc ccagcctctg       60
tccctgcgtc cggaggcatg tagacccgca gctggtgggg ccgtgcatac ccggggtctt      120
gacttcgcct gcgat                                                       135

<210>  21
<211>  72
<212>  DNA
<213>  ˹
<220>
<223>  Ĥ CD8tTM
<400>  21
atctacattt gggcccctct ggctggtact tgcggggtcc tgctgctttc actcgtgatc       60
actctttact gt                                                           72

<210>  22
<211>  126
<212>  DNA
<213>  ˹
<220>
<223>  ڴ̼ź 41-BB
<400>  22
aagcgcggtc ggaagaagct gctgtacatc tttaagcaac ccttcatgag gcctgtgcag       60
actactcaag aggaggacgg ctgttcatgc cggttcccag aggaggagga aggcggctgc      120
gaactg                                                                 126

<210>  23
<211>  336
<212>  DNA
<213>  ˹
<220>
<223>  CD3zeta
<400>  23
cgcgtgaaat tcagccgcag cgcagatgct ccagcctaca agcaggggca gaaccagctc       60
tacaacgaac tcaatcttgg tcggagagag gagtacgacg tgctggacaa gcggagagga      120
cgggacccag aaatgggcgg gaagccgcgc agaaagaatc cccaagaggg cctgtacaac      180
gagctccaaa aggataagat ggcagaagcc tatagcgaga ttggtatgaa aggggaacgc      240
agaagaggca aaggccacga cggactgtac cagggactca gcaccgccac caaggacacc      300
tatgacgctc ttcacatgca ggccctgccg cctcgg                                336

