                         SEQUENCE LISTING

<110>  Arxx Therapeutics AS
 
<120>  Humanized Antibody

<130>  P5791PC00

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  Antibody region

<400>  1

Asn Asp Tyr Tyr Trp Asn 
1               5       


<210>  2
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-H2


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  Antibody region

<400>  2

His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-H3


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  Antibody region

<400>  3

Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr 
1               5                   10      


<210>  4
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-H1


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  Antibody region

<400>  4

Gly Asp Ser Phe Thr Asn Asp Tyr Tyr 
1               5                   


<210>  5
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-H2


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  Antibody region

<400>  5

Ile Gly Tyr Gly Gly Asn Ile 
1               5           


<210>  6
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-H3


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  Antibody region

<400>  6

Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr 
1               5                   10              


<210>  7
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-L1


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  Antibody region

<400>  7

Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-L2


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  Antibody region

<400>  8

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-L3


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  Antibody region

<400>  9

Gln Gln Gly Asn Ser Leu Pro Arg Thr 
1               5                   


<210>  10
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-L1


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  Antibody region

<400>  10

Gln Asp Ile Arg Asn Tyr 
1               5       


<210>  11
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-L2


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  Antibody region

<400>  11

Tyr Thr Ser 
1           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-L3


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  Antibody region

<400>  12

Gln Gln Gly Asn Ser Leu Pro Arg Thr 
1               5                   


<210>  13
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH1


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Leu Ser Met Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  14
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH2


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Ser Ile Ser Ile Asp Thr Ser Arg Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Val Thr Ser Met Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH3


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  15

Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  16
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH4


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  16

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Arg Ser Val Thr Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  17
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH5


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  17

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  18
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL1


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  19
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL2


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  20
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL3


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  21
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL4


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  21

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  22
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL5


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  23
<211>  101
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(101)
<223>  Human S100A4 (protein) amino acids 1 to 101

<400>  23

Met Ala Cys Pro Leu Glu Lys Ala Leu Asp Val Met Val Ser Thr Phe 
1               5                   10                  15      


His Lys Tyr Ser Gly Lys Glu Gly Asp Lys Phe Lys Leu Asn Lys Ser 
            20                  25                  30          


Glu Leu Lys Glu Leu Leu Thr Arg Glu Leu Pro Ser Phe Leu Gly Lys 
        35                  40                  45              


Arg Thr Asp Glu Ala Ala Phe Gln Lys Leu Met Ser Asn Leu Asp Ser 
    50                  55                  60                  


Asn Arg Asp Asn Glu Val Asp Phe Gln Glu Tyr Cys Val Phe Leu Ser 
65                  70                  75                  80  


Cys Ile Ala Met Met Cys Asn Glu Phe Phe Glu Gly Phe Pro Asp Lys 
                85                  90                  95      


Gln Pro Arg Lys Lys 
            100     


<210>  24
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH1_H40Phe


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Leu Ser Met Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  25
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH1_H43Ser


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Ser Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Leu Ser Met Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  26
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH1_H44Lys


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Lys Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Leu Ser Met Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  27
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH2_H40Phe


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Ser Ile Ser Ile Asp Thr Ser Arg Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Val Thr Ser Met Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  28
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH2_H43Ser


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Ser Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Ser Ile Ser Ile Asp Thr Ser Arg Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Val Thr Ser Met Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  29
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH2_H44Lys


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Lys Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Ser Ile Ser Ile Asp Thr Ser Arg Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Val Thr Ser Met Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  30
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH3_H40Phe


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  30

Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  31
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH3_H43Ser


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  31

Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Ser Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  32
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH3_H44Lys


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  32

Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Lys Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  33
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH4_H40Phe


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Arg Ser Val Thr Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  34
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH4_H43Ser


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Ser Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Arg Ser Val Thr Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  35
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH4_H44Lys


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  35

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Lys Leu Glu Trp 
        35                  40                  45              


Ile Ala His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Arg Ser Val Thr Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  36
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH5_H40Phe


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  37
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH5_H43Ser


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  37

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Ser Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  38
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH5_H44Lys


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Antibody region

<400>  38

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Lys Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  39
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL1_L42Gly


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Gln Pro Gly Gly Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  40
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL1_L43Thr


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Gln Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  41
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL1_L44Leu


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Gln Pro Gly Lys Ala Leu Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  42
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL2_L42Gly


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  43
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL2_L43Thr


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  44
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL2_L44Leu


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Leu Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  45
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL3_L42Gly


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Ala Pro Lys Leu Leu Leu 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  46
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL3_L43Thr


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Leu 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  47
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL3_L44Leu


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Leu Lys Leu Leu Leu 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  48
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL4_L42Gly


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  48

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  49
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL4_L43Thr


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  49

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  50
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL4_L44Leu


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  50

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Gly Leu Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  51
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL5_L42Gly


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  51

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  52
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL5_L43Thr


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  52

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  53
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL5_L44Leu


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Antibody region

<400>  53

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Leu Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  54
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH region 6B12 monoclonal antibody (amino acid sequence) Leader 
       sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  leader sequence

<220>
<221>  MISC_FEATURE
<222>  (49)..(54)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (69)..(84)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (117)..(127)
<223>  CDR3

<400>  54

Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Phe Thr 
        35                  40                  45              


Asn Asp Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Ser Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Arg Leu Thr Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135             


<210>  55
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL region 6B12 monoclonal antibody (amino acid sequence) Leader 
       sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (44)..(54)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (70)..(76)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (109)..(117)
<223>  CDR3

<400>  55

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Gly Thr Leu 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Ser Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  56
<211>  326
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(326)
<223>  IgG4 CH

<400>  56

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325     


<210>  57
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  k light chain constant region (CL)

<400>  57

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  58
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AX-202 complete heavy chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(446)
<223>  Antibody region

<400>  58

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Thr Asn Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Gly Tyr Gly Gly Asn Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Leu Ser Met Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ser Phe Tyr Asp Gly Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  59
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AX-202 complete light chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(214)
<223>  Antibody region

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Leu Lys Leu Leu Leu 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


