                         SEQUENCE LISTING

<110>  Ospedale San Raffaele S.r.l.
       Consiglio Nazionale Delle Ricerche
 
<120>  EPIGENETIC SILENCING FOR TREATMENT OF CANCER

<130>  P121447PCT

<140>  PCT/EP2022/053711
<141>  2022-02-15

<150>  EP 21157246.6
<151>  2021-02-15

<160>  125   

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAB (Kruppel-associated box) domain of human zinc finger protein
       10

<400>  1

Ala Leu Ser Pro Gln His Ser Ala Val Thr Gln Gly Ser Ile Ile Lys 
1               5                   10                  15      


Asn Lys Glu Gly Met Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr 
            20                  25                  30          


Leu Val Thr Phe Lys Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp 
        35                  40                  45              


Lys Leu Leu Asp Thr Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu 
    50                  55                  60                  


Glu Asn Tyr Lys Asn Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro 
65                  70                  75                  80  


Asp Val Ile Leu Arg Leu Glu Lys Gly Glu Glu Pro Trp Leu Val Glu 
                85                  90                  95      


Arg Glu Ile His Gln Glu Thr His Pro Asp Ser Glu Thr Ala Phe Glu 
            100                 105                 110         


Ile Lys Ser Ser Val 
        115         


<210>  2
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAB domain of the ZIM3 protein

<400>  2

Met Asn Asn Ser Gln Gly Arg Val Thr Phe Glu Asp Val Thr Val Asn 
1               5                   10                  15      


Phe Thr Gln Gly Glu Trp Gln Arg Leu Asn Pro Glu Gln Arg Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Val Gly 
        35                  40                  45              


Gln Gly Glu Thr Thr Lys Pro Asp Val Ile Leu Arg Leu Glu Gln Gly 
    50                  55                  60                  


Lys Glu Pro Trp Leu Glu Glu Glu Glu Val Leu Gly Ser Gly Arg Ala 
65                  70                  75                  80  


Glu Lys Asn Gly Asp Ile Gly Gly Gln Ile Trp Lys Pro Lys Asp Val 
                85                  90                  95      


Lys Glu Ser Leu 
            100 


<210>  3
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAB domain of the ZNF350 protein

<400>  3

Ile Thr Leu Glu Asp Val Ala Val Asp Phe Thr Trp Glu Glu Trp Gln 
1               5                   10                  15      


Leu Leu Gly Ala Ala Gln Lys Asp Leu Tyr Arg Asp Val Met Leu Glu 
            20                  25                  30          


Asn Tyr Ser Asn Leu Val Ala Val Gly Tyr Gln Ala Ser Lys Pro Asp 
        35                  40                  45              


Ala Leu Phe Lys Leu Glu Gln Gly Glu Gln Leu Trp Thr Ile Glu Asp 
    50                  55                  60                  


Gly Ile His Ser Gly Ala Cys Ser 
65                  70          


<210>  4
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAB domain of the ZNF197 protein

<400>  4

Val Met Phe Glu Glu Val Ser Val Cys Phe Thr Ser Glu Glu Trp Ala 
1               5                   10                  15      


Cys Leu Gly Pro Ile Gln Arg Ala Leu Tyr Trp Asp Val Met Leu Glu 
            20                  25                  30          


Asn Tyr Gly Asn Val Thr Ser Leu Glu Trp Glu Thr Met Thr Glu Asn 
        35                  40                  45              


Glu Glu Val Thr Ser Lys Pro Ser Ser Ser Gln Arg Ala Asp Ser His 
    50                  55                  60                  


Lys Gly Thr Ser Lys Arg Leu Gln Gly 
65                  70              


<210>  5
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAB domain of the RBAK protein

<400>  5

Val Ser Phe Lys Asp Val Ala Val Asp Phe Thr Gln Glu Glu Trp Gln 
1               5                   10                  15      


Gln Leu Asp Pro Asp Glu Lys Ile Thr Tyr Arg Asp Val Met Leu Glu 
            20                  25                  30          


Asn Tyr Ser His Leu Val Ser Val Gly Tyr Asp Thr Thr Lys Pro Asn 
        35                  40                  45              


Val Ile Ile Lys Leu Glu Gln Gly Glu Glu Pro Trp Ile Met Gly Gly 
    50                  55                  60                  


Glu Phe Pro Cys Gln His Ser Pro 
65                  70          


<210>  6
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAB domain of the ZKSCAN1 protein

<400>  6

Val Lys Ile Glu Asp Met Ala Val Ser Leu Ile Leu Glu Glu Trp Gly 
1               5                   10                  15      


Cys Gln Asn Leu Ala Arg Arg Asn Leu Ser Arg Asp Asn Arg Gln Glu 
            20                  25                  30          


Asn Tyr Gly Ser Ala Phe Pro Gln Gly Gly Glu Asn Arg Asn Glu Asn 
        35                  40                  45              


Glu Glu Ser Thr Ser Lys Ala Glu Thr Ser Glu Asp Ser Ala Ser Arg 
    50                  55                  60                  


Gly Glu Thr Thr Gly Arg Ser Gln Lys Glu 
65                  70                  


<210>  7
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAB domain of the KRBOX4 protein

<400>  7

Leu Thr Phe Lys Asp Val Phe Val Asp Phe Thr Leu Glu Glu Trp Gln 
1               5                   10                  15      


Gln Leu Asp Ser Ala Gln Lys Asn Leu Tyr Arg Asp Val Met Leu Glu 
            20                  25                  30          


Asn Tyr Ser His Leu Val Ser Val Gly Tyr Leu Val Ala Lys Pro Asp 
        35                  40                  45              


Val Ile Phe Arg Leu Gly Pro Gly Glu Glu Ser Trp Met Ala Asp Gly 
    50                  55                  60                  


Gly Thr Pro Val Arg Thr Cys Ala 
65                  70          


<210>  8
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAB domain of the ZNF274 protein

<400>  8

Val Thr Phe Glu Asp Val Thr Leu Gly Phe Thr Pro Glu Glu Trp Gly 
1               5                   10                  15      


Leu Leu Asp Leu Lys Gln Lys Ser Leu Tyr Arg Glu Val Met Leu Glu 
            20                  25                  30          


Asn Tyr Arg Asn Leu Val Ser Val Glu His Gln Leu Ser Lys Pro Asp 
        35                  40                  45              


Val Val Ser Gln Leu Glu Glu Ala Glu Asp Phe Trp Pro Val Glu Arg 
    50                  55                  60                  


Gly Ile Pro Gln Asp Thr Ile Pro 
65                  70          


<210>  9
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding a KRAB domain

<400>  9
atggatgcta agtcactgac tgcctggtcc cggacactgg tgaccttcaa ggatgtgttt       60

gtggacttca ccagggagga gtggaagctg ctggacactg ctcagcagat cctgtacaga      120

aatgtgatgc tggagaacta taagaacctg gtttccttgg gttatcagct tactaagcca      180

gatgtgatcc tccggttgga gaagggagaa gagccctggc tggtggagag agaaattcac      240

caagagaccc atcctgattc agagactgca tttgaaatca aatcatcagt t               291


<210>  10
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  example DNMT3A sequence (DNA methyltransferase, DNMT)

<400>  10

Thr Tyr Gly Leu Leu Arg Arg Arg Glu Asp Trp Pro Ser Arg Leu Gln 
1               5                   10                  15      


Met Phe Phe Ala Asn Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val 
            20                  25                  30          


Tyr Pro Pro Val Pro Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser 
        35                  40                  45              


Leu Phe Asp Gly Ile Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly 
    50                  55                  60                  


Ile Gln Val Asp Arg Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile 
65                  70                  75                  80  


Thr Val Gly Met Val Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp 
                85                  90                  95      


Val Arg Ser Val Thr Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp 
            100                 105                 110         


Leu Val Ile Gly Gly Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro 
        115                 120                 125             


Ala Arg Lys Gly Leu Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe 
    130                 135                 140                 


Tyr Arg Leu Leu His Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro 
145                 150                 155                 160 


Phe Phe Trp Leu Phe Glu Asn Val Val Ala Met Gly Val Ser Asp Lys 
                165                 170                 175     


Arg Asp Ile Ser Arg Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala 
            180                 185                 190         


Lys Glu Val Ser Ala Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu 
        195                 200                 205             


Pro Gly Met Asn Arg Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu 
    210                 215                 220                 


Leu Gln Glu Cys Leu Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val 
225                 230                 235                 240 


Arg Thr Ile Thr Thr Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln 
                245                 250                 255     


His Phe Pro Val Phe Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr 
            260                 265                 270         


Glu Met Glu Arg Val Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser 
        275                 280                 285             


Asn Met Ser Arg Leu Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser 
    290                 295                 300                 


Val Pro Val Ile Arg His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala 
305                 310                 315                 320 


Cys Val 
        


<210>  11
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  example DNMT3B sequence

<400>  11

Cys His Gly Val Leu Arg Arg Arg Lys Asp Trp Asn Val Arg Leu Gln 
1               5                   10                  15      


Ala Phe Phe Thr Ser Asp Thr Gly Leu Glu Tyr Glu Ala Pro Lys Leu 
            20                  25                  30          


Tyr Pro Ala Ile Pro Ala Ala Arg Arg Arg Pro Ile Arg Val Leu Ser 
        35                  40                  45              


Leu Phe Asp Gly Ile Ala Thr Gly Tyr Leu Val Leu Lys Glu Leu Gly 
    50                  55                  60                  


Ile Lys Val Gly Lys Tyr Val Ala Ser Glu Val Cys Glu Glu Ser Ile 
65                  70                  75                  80  


Ala Val Gly Thr Val Lys His Glu Gly Asn Ile Lys Tyr Val Asn Asp 
                85                  90                  95      


Val Arg Asn Ile Thr Lys Lys Asn Ile Glu Glu Trp Gly Pro Phe Asp 
            100                 105                 110         


Leu Val Ile Gly Gly Ser Pro Cys Asn Asp Leu Ser Asn Val Asn Pro 
        115                 120                 125             


Ala Arg Lys Gly Leu Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe 
    130                 135                 140                 


Tyr His Leu Leu Asn Tyr Ser Arg Pro Lys Glu Gly Asp Asp Arg Pro 
145                 150                 155                 160 


Phe Phe Trp Met Phe Glu Asn Val Val Ala Met Lys Val Gly Asp Lys 
                165                 170                 175     


Arg Asp Ile Ser Arg Phe Leu Glu Cys Asn Pro Val Met Ile Asp Ala 
            180                 185                 190         


Ile Lys Val Ser Ala Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu 
        195                 200                 205             


Pro Gly Met Asn Arg Pro Val Ile Ala Ser Lys Asn Asp Lys Leu Glu 
    210                 215                 220                 


Leu Gln Asp Cys Leu Glu Tyr Asn Arg Ile Ala Lys Leu Lys Lys Val 
225                 230                 235                 240 


Gln Thr Ile Thr Thr Lys Ser Asn Ser Ile Lys Gln Gly Lys Asn Gln 
                245                 250                 255     


Leu Phe Pro Val Val Met Asn Gly Lys Glu Asp Val Leu Trp Cys Thr 
            260                 265                 270         


Glu Leu Glu Arg Ile Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser 
        275                 280                 285             


Asn Met Gly Arg Gly Ala Arg Gln Lys Leu Leu Gly Arg Ser Trp Ser 
    290                 295                 300                 


Val Pro Val Ile Arg His Leu Phe Ala Pro Leu Lys Asp Tyr Phe Ala 
305                 310                 315                 320 


Cys Glu 
        


<210>  12
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  example DNMT3B sequence

<400>  12

Met Val Ala Glu Leu Ile Ser Glu Glu Asp Leu Glu Phe Met Lys Gly 
1               5                   10                  15      


Asp Thr Arg His Leu Asn Gly Glu Glu Asp Ala Gly Gly Arg Glu Asp 
            20                  25                  30          


Ser Ile Leu Val Asn Gly Ala Cys Ser Asp Gln Ser Ser Asp Ser Pro 
        35                  40                  45              


Pro Ile Leu Glu Ala Ile Arg Thr Pro Glu Ile Arg Gly Arg Arg Ser 
    50                  55                  60                  


Ser Ser Arg Leu Ser Lys Arg Glu Val Ser Ser Leu Leu Ser Tyr Thr 
65                  70                  75                  80  


Gln Asp Leu Thr Gly Asp Gly Asp Gly Glu Asp Gly Asp Gly Ser Asp 
                85                  90                  95      


Thr Pro Val Met Pro Lys Leu Phe Arg Glu Thr Arg Thr Arg Ser Glu 
            100                 105                 110         


Ser Pro Ala Val Arg Thr Arg Asn Asn Asn Ser Val Ser Ser Arg Glu 
        115                 120                 125             


Arg His Arg Pro Ser Pro Arg Ser Thr Arg Gly Arg Gln Gly Arg Asn 
    130                 135                 140                 


His Val Asp Glu Ser Pro Val Glu Phe Pro Ala Thr Arg Ser Leu Arg 
145                 150                 155                 160 


Arg Arg Ala Thr Ala Ser Ala Gly Thr Pro Trp Pro Ser Pro Pro Ser 
                165                 170                 175     


Ser Tyr Leu Thr Ile Asp Leu Thr Asp Asp Thr Glu Asp Thr His Gly 
            180                 185                 190         


Thr Pro Gln Ser Ser Ser Thr Pro Tyr Ala Arg Leu Ala Gln Asp Ser 
        195                 200                 205             


Gln Gln Gly Gly Met Glu Ser Pro Gln Val Glu Ala Asp Ser Gly Asp 
    210                 215                 220                 


Gly Asp Ser Ser Glu Tyr Gln Asp Gly Lys Glu Phe Gly Ile Gly Asp 
225                 230                 235                 240 


Leu Val Trp Gly Lys Ile Lys Gly Phe Ser Trp Trp Pro Ala Met Val 
                245                 250                 255     


Val Ser Trp Lys Ala Thr Ser Lys Arg Gln Ala Met Ser Gly Met Arg 
            260                 265                 270         


Trp Val Gln Trp Phe Gly Asp Gly Lys Phe Ser Glu Val Ser Ala Asp 
        275                 280                 285             


Lys Leu Val Ala Leu Gly Leu Phe Ser Gln His Phe Asn Leu Ala Thr 
    290                 295                 300                 


Phe Asn Lys Leu Val Ser Tyr Arg Lys Ala Met Tyr His Ala Leu Glu 
305                 310                 315                 320 


Lys Ala Arg Val Arg Ala Gly Lys Thr Phe Pro Ser Ser Pro Gly Asp 
                325                 330                 335     


Ser Leu Glu Asp Gln Leu Lys Pro Met Leu Glu Trp Ala His Gly Gly 
            340                 345                 350         


Phe Lys Pro Thr Gly Ile Glu Gly Leu Lys Pro Asn Asn Thr Gln Pro 
        355                 360                 365             


Glu Asn Lys Thr Arg Arg Arg Thr Ala Asp Asp Ser Ala Thr Ser Asp 
    370                 375                 380                 


Tyr Cys Pro Ala Pro Lys Arg Leu Lys Thr Asn Cys Tyr Asn Asn Gly 
385                 390                 395                 400 


Lys Asp Arg Gly Asp Glu Asp Gln Ser Arg Glu Gln Met Ala Ser Asp 
                405                 410                 415     


Val Ala Asn Asn Lys Ser Ser Leu Glu Asp Gly Cys Leu Ser Cys Gly 
            420                 425                 430         


Arg Lys Asn Pro Val Ser Phe His Pro Leu Phe Glu Gly Gly Leu Cys 
        435                 440                 445             


Gln Thr Cys Arg Asp Arg Phe Leu Glu Leu Phe Tyr Met Tyr Asp Asp 
    450                 455                 460                 


Asp Gly Tyr Gln Ser Tyr Cys Thr Val Cys Cys Glu Gly Arg Glu Leu 
465                 470                 475                 480 


Leu Leu Cys Ser Asn Thr Ser Cys Cys Arg Cys Phe Cys Val Glu Cys 
                485                 490                 495     


Leu Glu Val Leu Val Gly Thr Gly Thr Ala Ala Glu Ala Lys Leu Gln 
            500                 505                 510         


Glu Pro Trp Ser Cys Tyr Met Cys Leu Pro Gln Arg Cys His Gly Val 
        515                 520                 525             


Leu Arg Arg Arg Lys Asp Trp Asn Val Arg Leu Gln Ala Phe Phe Thr 
    530                 535                 540                 


Ser Asp Thr Gly Leu Glu Tyr Glu Ala Pro Lys Leu Tyr Pro Ala Ile 
545                 550                 555                 560 


Pro Ala Ala Arg Arg Arg Pro Ile Arg Val Leu Ser Leu Phe Asp Gly 
                565                 570                 575     


Ile Ala Thr Gly Tyr Leu Val Leu Lys Glu Leu Gly Ile Lys Val Gly 
            580                 585                 590         


Lys Tyr Val Ala Ser Glu Val Cys Glu Glu Ser Ile Ala Val Gly Thr 
        595                 600                 605             


Val Lys His Glu Gly Asn Ile Lys Tyr Val Asn Asp Val Arg Asn Ile 
    610                 615                 620                 


Thr Lys Lys Asn Ile Glu Glu Trp Gly Pro Phe Asp Leu Val Ile Gly 
625                 630                 635                 640 


Gly Ser Pro Cys Asn Asp Leu Ser Asn Val Asn Pro Ala Arg Lys Gly 
                645                 650                 655     


Leu Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr His Leu Leu 
            660                 665                 670         


Asn Tyr Ser Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe Trp Met 
        675                 680                 685             


Phe Glu Asn Val Val Ala Met Lys Val Gly Asp Lys Arg Asp Ile Ser 
    690                 695                 700                 


Arg Phe Leu Glu Cys Asn Pro Val Met Ile Asp Ala Ile Lys Val Ser 
705                 710                 715                 720 


Ala Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly Met Asn 
                725                 730                 735     


Arg Pro Val Ile Ala Ser Lys Asn Asp Lys Leu Glu Leu Gln Asp Cys 
            740                 745                 750         


Leu Glu Tyr Asn Arg Ile Ala Lys Leu Lys Lys Val Gln Thr Ile Thr 
        755                 760                 765             


Thr Lys Ser Asn Ser Ile Lys Gln Gly Lys Asn Gln Leu Phe Pro Val 
    770                 775                 780                 


Val Met Asn Gly Lys Glu Asp Val Leu Trp Cys Thr Glu Leu Glu Arg 
785                 790                 795                 800 


Ile Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn Met Gly Arg 
                805                 810                 815     


Gly Ala Arg Gln Lys Leu Leu Gly Arg Ser Trp Ser Val Pro Val Ile 
            820                 825                 830         


Arg His Leu Phe Ala Pro Leu Lys Asp Tyr Phe Ala Cys Glu 
        835                 840                 845     


<210>  13
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  example DNMT1 sequence

<400>  13

Leu Arg Thr Leu Asp Val Phe Ser Gly Cys Gly Gly Leu Ser Glu Gly 
1               5                   10                  15      


Phe His Gln Ala Gly Ile Ser Asp Thr Leu Trp Ala Ile Glu Met Trp 
            20                  25                  30          


Asp Pro Ala Ala Gln Ala Phe Arg Leu Asn Asn Pro Gly Ser Thr Val 
        35                  40                  45              


Phe Thr Glu Asp Cys Asn Ile Leu Leu Lys Leu Val Met Ala Gly Glu 
    50                  55                  60                  


Thr Thr Asn Ser Arg Gly Gln Arg Leu Pro Gln Lys Gly Asp Val Glu 
65                  70                  75                  80  


Met Leu Cys Gly Gly Pro Pro Cys Gln Gly Phe Ser Gly Met Asn Arg 
                85                  90                  95      


Phe Asn Ser Arg Thr Tyr Ser Lys Phe Lys Asn Ser Leu Val Val Ser 
            100                 105                 110         


Phe Leu Ser Tyr Cys Asp Tyr Tyr Arg Pro Arg Phe Phe Leu Leu Glu 
        115                 120                 125             


Asn Val Arg Asn Phe Val Ser Phe Lys Arg Ser Met Val Leu Lys Leu 
    130                 135                 140                 


Thr Leu Arg Cys Leu Val Arg Met Gly Tyr Gln Cys Thr Phe Gly Val 
145                 150                 155                 160 


Leu Gln Ala Gly Gln Tyr Gly Val Ala Gln Thr Arg Arg Arg Ala Ile 
                165                 170                 175     


Ile Leu Ala Ala Ala Pro Gly Glu Lys Leu Pro Leu Phe Pro Glu Pro 
            180                 185                 190         


Leu His Val Phe Ala Pro Arg Ala Cys Gln Leu Ser Val Val Val Asp 
        195                 200                 205             


Asp Lys Lys Phe Val Ser Asn Ile Thr Arg Leu Ser Ser Gly Pro Phe 
    210                 215                 220                 


Arg Thr Ile Thr Val Arg Asp Thr Met Ser Asp Leu Pro Glu Val Arg 
225                 230                 235                 240 


Asn Gly Ala Ser Ala Leu Glu Ile Ser Tyr Asn Gly Glu Pro Gln Ser 
                245                 250                 255     


Trp Phe Gln Arg Gln Leu Arg Gly Ala Gln Tyr Gln Pro Ile Leu Arg 
            260                 265                 270         


Asp His Ile Cys Lys Asp Met Ser Ala Leu Val Ala Ala Arg Met Arg 
        275                 280                 285             


His Ile Pro Leu Ala Pro Gly Ser Asp Trp Arg Asp Leu Pro Asn Ile 
    290                 295                 300                 


Glu Val Arg Leu Ser Asp Gly Thr Met Ala Arg Lys Leu Arg Tyr Thr 
305                 310                 315                 320 


His His Asp Arg Lys Asn Gly Arg Ser Ser Ser Gly Ala Leu Arg Gly 
                325                 330                 335     


Val Cys Ser Cys Val Glu Ala Gly Lys Ala Cys Asp Pro Ala Ala Arg 
            340                 345                 350         


Gln Phe Asn Thr Leu Ile Pro Trp Cys Leu Pro His Thr Gly Asn Arg 
        355                 360                 365             


His Asn His Trp Ala Gly Leu Tyr Gly Arg Leu Glu Trp Asp Gly Phe 
    370                 375                 380                 


Phe Ser Thr Thr Val Thr Asn Pro Glu Pro Met Gly Lys Gln Gly Arg 
385                 390                 395                 400 


Val Leu His Pro Glu Gln His Arg Val Val Ser Val Arg Glu Cys Ala 
                405                 410                 415     


Arg Ser Gln Gly Phe Pro Asp Thr Tyr Arg Leu Phe Gly Asn Ile Leu 
            420                 425                 430         


Asp Lys His Arg Gln Val Gly Asn Ala Val Pro Pro Pro Leu Ala Lys 
        435                 440                 445             


Ala Ile Gly Leu Glu Ile Lys Leu Cys Met Leu Ala Lys Ala Arg Glu 
    450                 455                 460                 


Ser Ala Ser Ala Lys Ile Lys Glu Glu Glu Ala Ala Lys Asp 
465                 470                 475             


<210>  14
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  example DNMT3L (DNA (cytosine-5)-methyltransferase 3-like) 
       sequence

<400>  14

Met Ala Ala Ile Pro Ala Leu Asp Pro Glu Ala Glu Pro Ser Met Asp 
1               5                   10                  15      


Val Ile Leu Val Gly Ser Ser Glu Leu Ser Ser Ser Val Ser Pro Gly 
            20                  25                  30          


Thr Gly Arg Asp Leu Ile Ala Tyr Glu Val Lys Ala Asn Gln Arg Asn 
        35                  40                  45              


Ile Glu Asp Ile Cys Ile Cys Cys Gly Ser Leu Gln Val His Thr Gln 
    50                  55                  60                  


His Pro Leu Phe Glu Gly Gly Ile Cys Ala Pro Cys Lys Asp Lys Phe 
65                  70                  75                  80  


Leu Asp Ala Leu Phe Leu Tyr Asp Asp Asp Gly Tyr Gln Ser Tyr Cys 
                85                  90                  95      


Ser Ile Cys Cys Ser Gly Glu Thr Leu Leu Ile Cys Gly Asn Pro Asp 
            100                 105                 110         


Cys Thr Arg Cys Tyr Cys Phe Glu Cys Val Asp Ser Leu Val Gly Pro 
        115                 120                 125             


Gly Thr Ser Gly Lys Val His Ala Met Ser Asn Trp Val Cys Tyr Leu 
    130                 135                 140                 


Cys Leu Pro Ser Ser Arg Ser Gly Leu Leu Gln Arg Arg Arg Lys Trp 
145                 150                 155                 160 


Arg Ser Gln Leu Lys Ala Phe Tyr Asp Arg Glu Ser Glu Asn Pro Leu 
                165                 170                 175     


Glu Met Phe Glu Thr Val Pro Val Trp Arg Arg Gln Pro Val Arg Val 
            180                 185                 190         


Leu Ser Leu Phe Glu Asp Ile Lys Lys Glu Leu Thr Ser Leu Gly Phe 
        195                 200                 205             


Leu Glu Ser Gly Ser Asp Pro Gly Gln Leu Lys His Val Val Asp Val 
    210                 215                 220                 


Thr Asp Thr Val Arg Lys Asp Val Glu Glu Trp Gly Pro Phe Asp Leu 
225                 230                 235                 240 


Val Tyr Gly Ala Thr Pro Pro Leu Gly His Thr Cys Asp Arg Pro Pro 
                245                 250                 255     


Ser Trp Tyr Leu Phe Gln Phe His Arg Leu Leu Gln Tyr Ala Arg Pro 
            260                 265                 270         


Lys Pro Gly Ser Pro Arg Pro Phe Phe Trp Met Phe Val Asp Asn Leu 
        275                 280                 285             


Val Leu Asn Lys Glu Asp Leu Asp Val Ala Ser Arg Phe Leu Glu Met 
    290                 295                 300                 


Glu Pro Val Thr Ile Pro Asp Val His Gly Gly Ser Leu Gln Asn Ala 
305                 310                 315                 320 


Val Arg Val Trp Ser Asn Ile Pro Ala Ile Arg Ser Arg His Trp Ala 
                325                 330                 335     


Leu Val Ser Glu Glu Glu Leu Ser Leu Leu Ala Gln Asn Lys Gln Ser 
            340                 345                 350         


Ser Lys Leu Ala Ala Lys Trp Pro Thr Lys Leu Val Lys Asn Cys Phe 
        355                 360                 365             


Leu Pro Leu Arg Glu Tyr Phe Lys Tyr Phe Ser Thr Glu Leu Thr Ser 
    370                 375                 380                 


Ser Leu 
385     


<210>  15
<211>  1629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example sequence encoding DNMT3A and DNMT3L domains

<400>  15
aaccatgatc aagagttcga tcctcctaaa gtgtatcccc ctgtccctgc cgaaaagcgg       60

aaaccgatca gggttctcag tctcttcgat ggaattgcca caggcctctt ggtccttaag      120

gacctgggca tccaagtgga ccgctacatc gcctcagaag tatgtgagga cagcatcaca      180

gtcggcatgg tgcgccacca ggggaaaata atgtacgtcg gcgacgtcag atcagttact      240

cagaaacata ttcaggaatg ggggcctttt gatctcgtaa ttggcggcag cccctgcaat      300

gatctgagta ttgtgaaccc cgcccggaaa ggtttgtacg aaggtacggg cagactgttc      360

ttcgagtttt acagactgtt gcacgacgca cgaccaaagg agggtgacga tcgacccttc      420

ttctggctgt tcgagaacgt ggtcgctatg ggcgtgtctg acaagcggga catttctaga      480

ttcctggaga gcaatccagt gatgattgat gcaaaggaag tatccgctgc ccaccgcgcc      540

agatacttct ggggcaatct gcccggcatg aatcgaccct tggcaagcac cgtgaatgat      600

aagttggagt tgcaggagtg tctggagcat gggcggatcg caaagtttag caaggtgcgg      660

accatcacga cccgaagcaa ttcaattaag cagggaaagg accaacattt tccagtgttt      720

atgaacgaga aagaggacat cctgtggtgc acagaaatgg agcgggtttt cggattcccc      780

gtacattata ctgatgtgtc caatatgtct aggttggcta gacagaggct gttgggacgc      840

tcatggagtg ttcctgtcat ccgccacctg ttcgctcctc tgaaggagta tttcgcctgc      900

gtttcatccg ggaattcaaa cgcaaacagc agaggcccat ccttttcttc cggcctggtg      960

ccacttagtc tgcgcggctc tcacatggga cctatggaaa tatacaaaac agtgagcgcc     1020

tggaagaggc agcctgtgcg ggtcctgagt ctgttcagaa acattgacaa ggtgcttaag     1080

tcccttggat ttctggagtc tggcagcggt tctgggggtg gcacccttaa gtatgtggag     1140

gacgtgacaa acgtcgtgag gagagatgtg gagaaatggg ggccatttga cctggtatac     1200

gggagcactc aacctctcgg ttcttcttgt gatcgctgcc cagggtggta tatgtttcag     1260

ttccatcgca tcctgcaata cgcccttccg cggcaggaga gtcagcgacc attcttctgg     1320

atattcatgg acaatctcct gctgacagag gacgaccaag agactacgac tagatttctt     1380

cagaccgagg ccgttactct ccaggacgtt agaggtaggg actaccagaa tgccatgcga     1440

gtgtggagta acatccccgg actcaagtca aagcacgcac ccctgacccc caaggaagag     1500

gaatacctcc aggcgcaggt gaggagccgc agtaagctcg atgctcctaa agtcgatttg     1560

ttggtgaaga attgcttgct gcccctgaga gagtacttta agtactttag ccagaacagc     1620

ttgccactg                                                             1629


<210>  16
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  example CS (Chromo Shadow) domain sequence

<400>  16

Met Leu Glu Pro Glu Lys Ile Ile Gly Ala Thr Asp Ser Cys Gly Asp 
1               5                   10                  15      


Leu Met Phe Leu Met Lys Trp Lys Asp Thr Asp Glu Ala Asp Leu Val 
            20                  25                  30          


Leu Ala Lys Glu Ala Asn Val Lys Cys Pro Gln Ile Val Ile Ala Phe 
        35                  40                  45              


Tyr Glu Glu Arg Leu Thr Trp His Ala Tyr Pro Glu 
    50                  55                  60  


<210>  17
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example nucleotide sequence encoding a CS domain

<400>  17
atgctggaac cagaaaagat cattggggca acagattcct gtggtgattt aatgttccta       60

atgaaatgga aagacacaga tgaagctgac ctggttcttg caaaagaagc taatgtgaaa      120

tgtccacaaa ttgtgatagc attttatgaa gagagactga catggcatgc atatcctgag      180


<210>  18
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  example Y-R (YAF2-RYBP) domain sequence

<400>  18

Met Arg Pro Arg Leu Lys Asn Val Asp Arg Ser Thr Ala Gln Gln Leu 
1               5                   10                  15      


Ala Val Thr Val Gly Asn Val Thr Val Ile Ile Thr Asp Phe Lys Glu 
            20                  25                  30          


Lys Thr Arg Ser Ser Ser Thr Ser Ser Ser Thr Val Thr Ser Ser Ala 
        35                  40                  45              


Gly Ser Glu Gln Gln Asn Gln 
    50                  55  


<210>  19
<211>  165
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example nucleotide sequence encoding a Y-R domain

<400>  19
atgaggcccc ggctgaaaaa cgtggacagg agcactgcac agcagttggc agtaactgtg       60

ggcaacgtca ccgtcattat cacagacttt aaggaaaaga ctcgctcctc atcgacatcc      120

tcatccacag tgacctccag tgcagggtca gaacagcaga accag                      165


<210>  20

<400>  20
000

<210>  21
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epigenetic effector domain, EnR

<400>  21

Met Ala Leu Glu Asp Arg Cys Ser Pro Gln Ser Ala Pro Ser Pro Ile 
1               5                   10                  15      


Thr Leu Gln Met Gln His Leu His His Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Met Gln His Leu His Gln Leu Gln Gln Leu Gln Gln 
        35                  40                  45              


Leu His Gln Gln Gln Leu Ala Ala Gly Val Phe His His Pro Ala Met 
    50                  55                  60                  


Ala Phe Asp Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala His Ala His Ala Ala Ala Leu Gln Gln Arg Leu Ser Gly Ser Gly 
                85                  90                  95      


Ser Pro Ala Ser Cys Ser Thr Pro Ala Ser Ser Thr Pro Leu Thr Ile 
            100                 105                 110         


Lys Glu Glu Glu Ser Asp Ser Val Ile Gly Asp Met Ser Phe His Asn 
        115                 120                 125             


Gln Thr His Thr Thr Asn Glu Glu Glu Glu Ala Glu Glu Asp Asp Asp 
    130                 135                 140                 


Ile Asp Val Asp Val Asp Asp Thr Ser Ala Gly Gly Arg Leu Pro Pro 
145                 150                 155                 160 


Pro Ala His Gln Gln Gln Ser Thr Ala Lys Pro Ser Leu Ala Phe Ser 
                165                 170                 175     


Ile Ser Asn Ile Leu Ser Asp Arg Phe Gly Asp Val Gln Lys Pro Gly 
            180                 185                 190         


Lys Ser Met Glu Asn Gln Ala Ser Ile Phe Arg Pro Phe Glu Ala Ser 
        195                 200                 205             


Arg Ser Gln Thr Ala Thr Pro Ser Ala Phe Thr Arg Val Asp Leu Leu 
    210                 215                 220                 


Glu Phe Ser Arg Gln Gln Gln Ala Ala Ala Ala Ala Ala Thr Ala Ala 
225                 230                 235                 240 


Met Met Leu Glu Arg Ala Asn Phe Leu Asn Cys Phe Asn Pro Ala Ala 
                245                 250                 255     


Tyr Pro Arg Ile His Glu Glu Ile Val Gln Ser Arg Leu Arg Arg Ser 
            260                 265                 270         


Ala Ala Asn Ala Val Ile Pro Pro Pro Met Ser Ser Lys Met Ser Asp 
        275                 280                 285             


Ala Asn Pro Glu Lys Ser Ala Leu 
    290                 295     


<210>  22
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epigenetic effector domain, MECP2

<400>  22

Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Val Gln Val Lys Arg 
1               5                   10                  15      


Val Leu Glu Lys Ser Pro Gly Lys Leu Leu Val Lys Met Pro Phe Gln 
            20                  25                  30          


Ala Ser Pro Gly Gly Lys Gly Glu Gly Gly Gly Ala Thr Thr Ser Ala 
        35                  40                  45              


Gln Val Met Val Ile Lys Arg Pro Gly Arg Lys Arg Lys Ala Glu Ala 
    50                  55                  60                  


Asp Pro Gln Ala Ile Pro Lys Lys Arg Gly Arg Lys Pro Gly Ser Val 
65                  70                  75                  80  


Val Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala Val Lys Glu Ser 
                85                  90                  95      


Ser Ile Arg Ser Val Gln Glu Thr Val Leu Pro Ile Lys Lys Arg Lys 
            100                 105                 110         


Thr Arg Glu Thr Val Ser Ile Glu Val Lys Glu Val Val Lys Pro Leu 
        115                 120                 125             


Leu Val Ser Thr Leu Gly Glu Lys Ser Gly Lys Gly Leu Lys Thr Cys 
    130                 135                 140                 


Lys Ser Pro Gly Arg Lys Ser Lys Glu Ser Ser Pro Lys Gly Arg Ser 
145                 150                 155                 160 


Ser Ser Ala Ser Ser Pro Pro Lys Lys Glu His His His His His His 
                165                 170                 175     


His Ala Glu Ser Pro Lys Ala Pro Met Pro Leu Leu Pro Pro Pro Pro 
            180                 185                 190         


Pro Pro Glu Pro Gln Ser Ser Glu Asp Pro Ile Ser Pro Pro Glu Pro 
        195                 200                 205             


Gln Asp Leu Ser Ser Ser Ile Cys Lys Glu Glu Lys Met Pro Arg Ala 
    210                 215                 220                 


Gly Ser Leu Glu Ser Asp Gly Cys Pro Lys Glu Pro Ala Lys Thr Gln 
225                 230                 235                 240 


Pro Met Val Ala Ala Ala Ala Thr Thr Thr Thr Thr Thr Thr Thr Thr 
                245                 250                 255     


Val Ala Glu Lys Tyr Lys His Arg Gly Glu Gly Glu Arg Lys Asp Ile 
            260                 265                 270         


Val Ser Ser Ser Met Pro Arg Pro Asn Arg Glu Glu Pro Val Asp Ser 
        275                 280                 285             


Arg Thr Pro Val Thr Glu Arg Val Ser 
    290                 295         


<210>  23
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epigenetic effector domain, GLI3RD

<400>  23

Gly Thr Val Phe Ala Met Asp Pro Arg Asn Gly Tyr Met Glu Pro His 
1               5                   10                  15      


Tyr His Pro Pro His Leu Phe Pro Ala Phe His Pro Pro Val Pro Ile 
            20                  25                  30          


Asp Ala Arg His His Glu Gly Arg Tyr His Tyr Asp Pro Ser Pro Ile 
        35                  40                  45              


Pro Pro Leu His Met Thr Ser Ala Leu Ser Ser Ser Pro Thr Tyr Pro 
    50                  55                  60                  


Asp Leu Pro Phe Ile Arg Ile Ser Pro His Arg Asn Pro Thr Ala Ala 
65                  70                  75                  80  


Ser Glu Ser Pro Phe Ser Pro Pro His Pro Tyr Ile Asn Pro Tyr Met 
                85                  90                  95      


Asp Tyr Ile Arg Ser Leu His Ser Ser Pro Ser Leu Ser Met Ile Ser 
            100                 105                 110         


Ala Thr Arg Gly Leu Ser Pro Thr Asp Ala Pro His Ala Gly Val Ser 
        115                 120                 125             


Pro Ala Glu 
    130     


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epigenetic effector domain, MAD1RD

<400>  24

Arg Met Asn Ile Gln Met Leu Leu Glu Ala Ala Asp Tyr Leu Glu Arg 
1               5                   10                  15      


<210>  25
<211>  300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding epigenetic effector domain, ZIM3-KRAB

<400>  25
atgaacaatt cccagggaag agtgaccttc gaggatgtca ctgtgaactt cacccagggg       60

gagtggcagc ggctgaatcc cgaacagaga aacttgtaca gggatgtgat gctggagaat      120

tacagcaacc ttgtctctgt gggacaaggg gaaaccacca aacccgatgt gatcttgagg      180

ttggaacaag gaaaggagcc atggttggag gaagaggaag tgctgggaag tggccgtgca      240

gaaaaaaatg gggacattgg agggcagatt tggaagccaa aggatgtgaa agagagtctc      300


<210>  26
<211>  888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding epigenetic effector domain, EnR

<400>  26
atggccctgg aggatcgctg cagtccacag tcagcgccca gccccattac cctacaaatg       60

cagcatcttc accaccagca acagcagcag cagcaacagc agcagcaaat gcagcacctc      120

caccagctgc agcaactgca gcagttgcac caacagcaac tggccgccgg tgtcttccac      180

catccggcaa tggccttcga tgccgctgca gccgccgctg ctgcagctgc tgctgcggcc      240

gcccacgctc atgctgctgc actgcagcag cgcctcagtg gcagtggatc gcccgcatcc      300

tgctccacgc ccgcctcgtc cacgccgctg accatcaagg aggaggaaag cgactccgtg      360

atcggtgaca tgagtttcca caatcagacg cacaccacca acgaggagga ggaggcggag      420

gaggatgacg acattgatgt ggatgtggat gatacgtcgg cgggcggacg cctgccacca      480

cccgcccacc agcagcagtc gacggccaag ccctcgctgg ccttttccat ctccaacatc      540

ctgagcgatc gtttcggaga tgtccagaag ccgggcaagt cgatggagaa ccaggccagc      600

atattccgcc ccttcgaggc gagtcgttcc cagactgcca cgccctccgc ctttacaaga      660

gtggatctgc tggagtttag ccggcaacag caggctgccg ccgcagccgc tactgcggcc      720

atgatgctgg aacgggccaa cttccttaac tgcttcaatc cggctgccta tcccaggata      780

cacgaggaaa tcgtgcagag tcggctgcgc aggagtgcag ccaatgccgt catcccgccg      840

cccatgagct ccaagatgag cgatgccaat ccagagaaat ctgctctg                   888


<210>  27
<211>  891
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding epigenetic effector domain, MECP2

<400>  27
agcccaaaga agaaacggaa ggtggaagcc tcagtgcagg tgaaaagggt gctggaaaaa       60

tcccccggca aactcctcgt gaagatgccc ttccaggctt cccctggcgg aaaaggtgaa      120

gggggtggcg caaccacatc tgcccaggtc atggtcatca agcgacctgg aaggaaaaga      180

aaggccgagg ctgaccctca ggccattcca aagaaacggg gacgcaagcc agggtccgtg      240

gtcgcagctg cagcagctga ggctaagaaa aaggcagtga aggaaagctc catccgcagt      300

gtgcaggaga ctgtcctgcc catcaagaag aggaagacta gggagaccgt gtccatcgag      360

gtcaaagaag tggtcaagcc cctgctcgtg tccaccctgg gcgaaaaatc tggaaagggg      420

ctcaaaacat gcaagtcacc tggacggaaa agcaaggagt ctagtccaaa ggggcgctca      480

agctccgctt ctagtccccc taaaaaggaa caccatcacc atcaccatca cgccgagtct      540

cctaaggctc ctatgccact gctcccacca cctccaccac ctgagccaca gtcaagcgaa      600

gaccccatca gcccacccga gcctcaggat ctgtcctcta gtatttgcaa agaggaaaag      660

atgcccagag caggcagcct ggagagtgat ggctgtccaa aagaacccgc caagacccag      720

cctatggtgg cagccgctgc aactaccacc acaaccacaa ctaccacagt ggccgaaaaa      780

tacaagcatc gcggcgaggg cgaacgaaag gacattgtgt caagctccat gcccagacct      840

aaccgggagg aaccagtcga tagtaggaca cccgtgactg agagagtctc a               891


<210>  28
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding epigenetic effector domain, GLI3RD

<400>  28
gggacggtgt ttgccatgga ccccaggaat ggttacatgg agccccacta ccaccctcct       60

catcttttcc ctgccttcca tcctcctgta ccaattgatg ccagacatca tgagggccgt      120

taccattacg atccatctcc gattcctcca ttgcatatga cttccgcctt atctagtagc      180

cctacgtatc cggacctgcc cttcattagg atctccccac accggaaccc cactgctgct      240

tccgagtctc ccttcagccc tccacatccc tacattaatc cctacatgga ctatatccgc      300

tccttgcaca gcagcccatc gctctccatg atctcagcaa cccgtgggct gagccctaca      360

gatgcgcccc atgcaggagt cagcccagca gaa                                   393


<210>  29
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding epigenetic effector domain, MAD1RD

<400>  29
cggatgaaca tccagatgct gctggaggcg gccgactatc tggagcgg                    48


<210>  30
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, SOX2

<400>  30

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly 
            


<210>  31
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, MYC

<400>  31

Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
1               5                   10                  15      


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly 
            20                  25                  30          


Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu 
        35                  40                  45              


Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
    50                  55                  60                  


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys 
65                  70                  75                  80  


Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
                85                  90                  95      


Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu 
            100                 105                 110         


His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln 
        115                 120                 125             


Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala 
    130                 135                 140                 


Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser 
145                 150                 155                 160 


Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr 
                165                 170                 175     


His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro 
            180                 185                 190         


Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile 
        195                 200                 205             


Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu 
    210                 215                 220                 


Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn 
225                 230                 235                 240 


Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu 
                245                 250                 255     


Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr 
            260                 265                 270         


Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu 
        275                 280                 285             


Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu 
    290                 295                 300                 


Gln Leu Arg Asn Ser Cys Ala 
305                 310     


<210>  32
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, MYCN

<400>  32

Met Pro Ser Cys Ser Thr Ser Thr Met Pro Gly Met Ile Cys Lys Asn 
1               5                   10                  15      


Pro Asp Leu Glu Phe Asp Ser Leu Gln Pro Cys Phe Tyr Pro Asp Glu 
            20                  25                  30          


Asp Asp Phe Tyr Phe Gly Gly Pro Asp Ser Thr Pro Pro Gly Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Gly Phe Ala Glu His Ser Ser Glu Pro Pro Ser Trp Val Thr Glu 
65                  70                  75                  80  


Met Leu Leu Glu Asn Glu Leu Trp Gly Ser Pro Ala Glu Glu Asp Ala 
                85                  90                  95      


Phe Gly Leu Gly Gly Leu Gly Gly Leu Thr Pro Asn Pro Val Ile Leu 
            100                 105                 110         


Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Arg Glu Lys Leu Glu Arg 
        115                 120                 125             


Ala Val Ser Glu Lys Leu Gln His Gly Arg Gly Pro Pro Thr Ala Gly 
    130                 135                 140                 


Ser Thr Ala Gln Ser Pro Gly Ala Gly Ala Ala Ser Pro Ala Gly Arg 
145                 150                 155                 160 


Gly His Gly Gly Ala Ala Gly Ala Gly Arg Ala Gly Ala Ala Leu Pro 
                165                 170                 175     


Ala Glu Leu Ala His Pro Ala Ala Glu Cys Val Asp Pro Ala Val Val 
            180                 185                 190         


Phe Pro Phe Pro Val Asn Lys Arg Glu Pro Ala Pro Val Pro Ala Ala 
        195                 200                 205             


Pro Ala Ser Ala Pro Ala Ala Gly Pro Ala Val Ala Ser Gly Ala Gly 
    210                 215                 220                 


Ile Ala Ala Pro Ala Gly Ala Pro Gly Val Ala Pro Pro Arg Pro Gly 
225                 230                 235                 240 


Gly Arg Gln Thr Ser Gly Gly Asp His Lys Ala Leu Ser Thr Ser Gly 
                245                 250                 255     


Glu Asp Thr Leu Ser Asp Ser Asp Asp Glu Asp Asp Glu Glu Glu Asp 
            260                 265                 270         


Glu Glu Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg Arg Ser Ser 
        275                 280                 285             


Ser Asn Thr Lys Ala Val Thr Thr Phe Thr Ile Thr Val Arg Pro Lys 
    290                 295                 300                 


Asn Ala Ala Leu Gly Pro Gly Arg Ala Gln Ser Ser Glu Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Cys Leu Pro Ile His Gln Gln His Asn Tyr Ala Ala Pro Ser 
                325                 330                 335     


Pro Tyr Val Glu Ser Glu Asp Ala Pro Pro Gln Lys Lys Ile Lys Ser 
            340                 345                 350         


Glu Ala Ser Pro Arg Pro Leu Lys Ser Val Ile Pro Pro Lys Ala Lys 
        355                 360                 365             


Ser Leu Ser Pro Arg Asn Ser Asp Ser Glu Asp Ser Glu Arg Arg Arg 
    370                 375                 380                 


Asn His Asn Ile Leu Glu Arg Gln Arg Arg Asn Asp Leu Arg Ser Ser 
385                 390                 395                 400 


Phe Leu Thr Leu Arg Asp His Val Pro Glu Leu Val Lys Asn Glu Lys 
                405                 410                 415     


Ala Ala Lys Val Val Ile Leu Lys Lys Ala Thr Glu Tyr Val His Ser 
            420                 425                 430         


Leu Gln Ala Glu Glu His Gln Leu Leu Leu Glu Lys Glu Lys Leu Gln 
        435                 440                 445             


Ala Arg Gln Gln Gln Leu Leu Lys Lys Ile Glu His Ala Arg Thr Cys 
    450                 455                 460                 


<210>  33
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       TEAD1

<400>  33

Ile Glu Pro Ser Ser Trp Ser Gly Ser Glu Ser Pro Ala Glu Asn Met 
1               5                   10                  15      


Glu Arg Met Ser Asp Ser Ala Asp Lys Pro Ile Asp Asn Asp Ala Glu 
            20                  25                  30          


Gly Val Trp Ser Pro Asp Ile Glu Gln Ser Phe Gln Glu Ala Leu Ala 
        35                  40                  45              


Ile Tyr Pro Pro Cys Gly Arg Arg Lys Ile Ile Leu Ser Asp Glu Gly 
    50                  55                  60                  


Lys Met Tyr Gly Arg Asn Glu Leu Ile Ala Arg Tyr Ile Lys Leu Arg 
65                  70                  75                  80  


Thr Gly Lys Thr Arg Thr Arg Lys Gln Val Ser Ser His Ile Gln Val 
                85                  90                  95      


Leu Ala Arg Arg Lys Ser Arg Asp Phe His Ser Lys Leu Lys Asp Gln 
            100                 105                 110         


Thr Ala Lys Asp Lys Ala Leu Gln His Met Ala Ala Met Ser Ser Ala 
        115                 120                 125             


Gln Ile Val Ser Ala Thr Ala Ile His Asn Lys Leu Gly Leu Pro Gly 
    130                 135                 140                 


Ile Pro Arg Pro Thr Phe Pro Gly Ala Pro Gly Phe Trp Pro Gly Met 
145                 150                 155                 160 


Ile Gln Thr Gly Gln Pro 
                165     


<210>  34
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       TEAD2

<400>  34

Met Gly Glu Pro Arg Ala Gly Ala Ala Leu Asp Asp Gly Ser Gly Trp 
1               5                   10                  15      


Thr Gly Ser Glu Glu Gly Ser Glu Glu Gly Thr Gly Gly Ser Glu Gly 
            20                  25                  30          


Ala Gly Gly Asp Gly Gly Pro Asp Ala Glu Gly Val Trp Ser Pro Asp 
        35                  40                  45              


Ile Glu Gln Ser Phe Gln Glu Ala Leu Ala Ile Tyr Pro Pro Cys Gly 
    50                  55                  60                  


Arg Arg Lys Ile Ile Leu Ser Asp Glu Gly Lys Met Tyr Gly Arg Asn 
65                  70                  75                  80  


Glu Leu Ile Ala Arg Tyr Ile Lys Leu Arg Thr Gly Lys Thr Arg Thr 
                85                  90                  95      


Arg Lys Gln Val Ser Ser His Ile Gln Val Leu Ala Arg Arg Lys Ser 
            100                 105                 110         


Arg Glu Ile Gln Ser Lys Leu Lys Asp Gln Val Ser Lys Asp Lys Ala 
        115                 120                 125             


Phe Gln Thr Met Ala Thr Met Ser Ser Ala Gln Leu Ile Ser Ala Pro 
    130                 135                 140                 


Ser Leu Gln Ala Lys Leu Gly Pro Thr Gly Pro Gln Ala Ser Glu Leu 
145                 150                 155                 160 


Phe Gln Phe Trp Ser Gly Gly Ser Gly Pro Pro Trp Asn Val Pro Asp 
                165                 170                 175     


Val Lys Pro Phe Ser Gln Thr Pro Phe Thr Leu Ser Leu Thr Pro Pro 
            180                 185                 190         


Ser Thr Asp Leu Pro Gly Tyr Glu Pro Pro Gln Ala Leu Ser Pro Leu 
        195                 200                 205             


Pro Pro Pro Thr Pro Ser Pro Pro Ala Trp Gln Ala Arg Gly Leu Gly 
    210                 215                 220                 


Thr Ala Arg Leu Gln Leu Val Glu Phe Ser Ala Phe Val Glu Pro Pro 
225                 230                 235                 240 


Asp Ala Val Asp Ser Tyr Gln Arg His Leu Phe Val His Ile Ser Gln 
                245                 250                 255     


His Cys Pro Ser Pro Gly Ala Pro Pro Leu Glu Ser Val Asp Val Arg 
            260                 265                 270         


Gln Ile Tyr Asp Lys Phe Pro Glu Lys Lys Gly Gly Leu Arg Glu Leu 
        275                 280                 285             


Tyr Asp Arg Gly Pro Pro His Ala Phe Phe Leu Val Lys Phe Trp Ala 
    290                 295                 300                 


Asp Leu Asn Trp Gly Pro Ser Gly Glu Glu Ala Gly Ala Gly Gly Ser 
305                 310                 315                 320 


Ile Ser Ser Gly Gly Phe Tyr Gly Val Ser Ser Gln Tyr Glu Ser Leu 
                325                 330                 335     


Glu His Met Thr Leu Thr Cys Ser Ser Lys Val Cys Ser Phe Gly Lys 
            340                 345                 350         


Gln Val Val Glu Lys Val Glu Thr Glu Arg Ala Gln Leu Glu Asp Gly 
        355                 360                 365             


Arg Phe Val Tyr Arg Leu Leu Arg Ser Pro Met Cys Glu Tyr Leu Val 
    370                 375                 380                 


Asn Phe Leu His Lys Leu Arg Gln Leu Pro Glu Arg Tyr Met Met Asn 
385                 390                 395                 400 


Ser Val Leu Glu Asn Phe Thr Ile Leu Gln Val Val Thr Asn Arg Asp 
                405                 410                 415     


Thr Gln Glu Leu Leu Leu Cys Thr Ala Tyr Val Phe Glu Val Ser Thr 
            420                 425                 430         


Ser Glu Arg Gly Ala Gln His His Ile Tyr Arg Leu Val Arg Asp 
        435                 440                 445         


<210>  35
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       TEAD3

<400>  35

Ile Ala Ser Asn Ser Trp Asn Ala Ser Ser Ser Pro Gly Glu Ala Arg 
1               5                   10                  15      


Glu Asp Gly Pro Glu Gly Leu Asp Lys Gly Leu Asp Asn Asp Ala Glu 
            20                  25                  30          


Gly Val Trp Ser Pro Asp Ile Glu Gln Ser Phe Gln Glu Ala Leu Ala 
        35                  40                  45              


Ile Tyr Pro Pro Cys Gly Arg Arg Lys Ile Ile Leu Ser Asp Glu Gly 
    50                  55                  60                  


Lys Met Tyr Gly Arg Asn Glu Leu Ile Ala Arg Tyr Ile Lys Leu Arg 
65                  70                  75                  80  


Thr Gly Lys Thr Arg Thr Arg Lys Gln Val Ser Ser His Ile Gln Val 
                85                  90                  95      


Leu Ala Arg Lys Lys Val Arg Glu Tyr Gln Val Gly Ile Lys Ala Met 
            100                 105                 110         


Asn Leu Asp Gln Val Ser Lys Asp Lys Ala Leu Gln Ser Met Ala Ser 
        115                 120                 125             


Met Ser Ser Ala Gln Ile Val Ser Ala Ser Val Leu Gln Asn Lys Phe 
    130                 135                 140                 


Ser Pro Pro Ser Pro Leu Pro Gln Ala Val Phe Ser Thr Ser Ser Arg 
145                 150                 155                 160 


Phe Trp Ser Ser Pro Pro Leu Leu Gly Gln Gln Pro Gly Pro Ser Gln 
                165                 170                 175     


Asp Ile Lys Pro Phe Ala Gln Pro Ala Tyr Pro Ile Gln Pro Pro Leu 
            180                 185                 190         


Pro Pro Thr Leu Ser Ser Tyr Glu Pro Leu Ala Pro Leu Pro Ser Ala 
        195                 200                 205             


Ala Ala Ser Val Pro Val Trp Gln Asp Arg Thr Ile Ala Ser Ser Arg 
    210                 215                 220                 


Leu Arg Leu Leu Glu Tyr Ser Ala Phe Met Glu Val Gln Arg Asp Pro 
225                 230                 235                 240 


Asp Thr Tyr Ser Lys His Leu Phe Val His Ile Gly Gln Thr Asn Pro 
                245                 250                 255     


Ala Phe Ser Asp Pro Pro Leu Glu Ala Val Asp Val Arg Gln Ile Tyr 
            260                 265                 270         


Asp Lys Phe Pro Glu Lys Lys Gly Gly Leu Lys Glu Leu Tyr Glu Lys 
        275                 280                 285             


Gly Pro Pro Asn Ala Phe Phe Leu Val Lys Phe Trp Ala Asp Leu Asn 
    290                 295                 300                 


Ser Thr Ile Gln Glu Gly Pro Gly Ala Phe Tyr Gly Val Ser Ser Gln 
305                 310                 315                 320 


Tyr Ser Ser Ala Asp Ser Met Thr Ile Ser Val Ser Thr Lys Val Cys 
                325                 330                 335     


Ser Phe Gly Lys Gln Val Val Glu Lys Val Glu Thr Glu Tyr Ala Arg 
            340                 345                 350         


Leu Glu Asn Gly Arg Phe Val Tyr Arg Ile His Arg Ser Pro Met Cys 
        355                 360                 365             


Glu Tyr Met Ile Asn Phe Ile His Lys Leu Lys His Leu Pro Glu Lys 
    370                 375                 380                 


Tyr Met Met Asn Ser Val Leu Glu Asn Phe Thr Ile Leu Gln Val Val 
385                 390                 395                 400 


Thr Ser Arg Asp Ser Gln Glu Thr Leu Leu Val Ile Ala Phe Val Phe 
                405                 410                 415     


Glu Val Ser Thr Ser Glu His Gly Ala Gln His His Val Tyr Lys Leu 
            420                 425                 430         


Val Lys Asp 
        435 


<210>  36
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       TEAD4

<400>  36

Leu Glu Gly Thr Ala Gly Thr Ile Thr Ser Asn Glu Trp Ser Ser Pro 
1               5                   10                  15      


Thr Ser Pro Glu Gly Ser Thr Ala Ser Gly Gly Ser Gln Ala Leu Asp 
            20                  25                  30          


Lys Pro Ile Asp Asn Asp Ala Glu Gly Val Trp Ser Pro Asp Ile Glu 
        35                  40                  45              


Gln Ser Phe Gln Glu Ala Leu Ala Ile Tyr Pro Pro Cys Gly Arg Arg 
    50                  55                  60                  


Lys Ile Ile Leu Ser Asp Glu Gly Lys Met Tyr Gly Arg Asn Glu Leu 
65                  70                  75                  80  


Ile Ala Arg Tyr Ile Lys Leu Arg Thr Gly Lys Thr Arg Thr Arg Lys 
                85                  90                  95      


Gln Val Ser Ser His Ile Gln Val Leu Ala Arg Arg Lys Ala Arg Glu 
            100                 105                 110         


Ile Gln Ala Lys Leu Lys Phe Trp Gln Gly Ala Leu Pro Gly Gln Ala 
        115                 120                 125             


Gly Thr Ser His Asp Val Lys Pro Phe Ser Gln Gln Thr Tyr Ala Val 
    130                 135                 140                 


Gln Pro Pro Leu Pro Leu Pro Gly Phe Glu Ser Pro Ala Gly Pro Ala 
145                 150                 155                 160 


Pro Ser Pro Ser Ala Pro Pro Ala Pro Pro Trp Gln Gly Arg Ser Val 
                165                 170                 175     


Ala Ser Ser Lys Leu Trp Met Leu Glu Phe Ser Ala Phe Leu Glu Gln 
            180                 185                 190         


Gln Gln Asp Pro Asp Thr Tyr Asn Lys His Leu Phe Val His Ile Gly 
        195                 200                 205             


Gln Ser Ser Pro Ser Tyr Ser Asp Pro Tyr Leu Glu Ala Val Asp Ile 
    210                 215                 220                 


Arg Gln Ile Tyr Asp Lys Phe Pro Glu Lys Lys Gly Gly Leu Lys Asp 
225                 230                 235                 240 


Leu Phe Glu Arg Gly Pro Ser Asn Ala Phe Phe Leu Val Lys Phe Trp 
                245                 250                 255     


Ala Asp Leu Asn Thr Asn Ile Glu Asp Glu Gly Ser Ser Phe Tyr Gly 
            260                 265                 270         


Val Ser Ser Gln Tyr Glu Ser Pro Glu Asn Met Ile Ile Thr Cys Ser 
        275                 280                 285             


Thr Lys Val Cys Ser Phe Gly Lys Gln Val Val Glu Lys Val Glu Thr 
    290                 295                 300                 


Glu Tyr Ala Arg Tyr Glu Asn Gly His Tyr Ser Tyr Arg Ile His Arg 
305                 310                 315                 320 


Ser Pro Leu Cys Glu Tyr Met Ile Asn Phe Ile His Lys Leu Lys His 
                325                 330                 335     


Leu Pro Glu Lys Tyr Met Met Asn Ser Val Leu Glu Asn Phe Thr Ile 
            340                 345                 350         


Leu Gln Val Val Thr Asn Arg Asp Thr Gln Glu Thr Leu Leu Cys Ile 
        355                 360                 365             


Ala Tyr Val Phe Glu Val Ser Ala Ser Glu His Gly Ala Gln His His 
    370                 375                 380                 


Ile Tyr Arg Leu Val Lys Glu 
385                 390     


<210>  37
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       FOXA1

<400>  37

Met Leu Gly Thr Val Lys Met Glu Gly His Glu Thr Ser Asp Trp Asn 
1               5                   10                  15      


Ser Tyr Tyr Ala Asp Thr Gln Glu Ala Tyr Ser Ser Val Pro Val Ser 
            20                  25                  30          


Asn Met Asn Ser Gly Leu Gly Ser Met Asn Ser Met Asn Thr Tyr Met 
        35                  40                  45              


Thr Met Asn Thr Met Thr Thr Ser Gly Asn Met Thr Pro Ala Ser Phe 
    50                  55                  60                  


Asn Met Ser Tyr Ala Asn Pro Gly Leu Gly Ala Gly Leu Ser Pro Gly 
65                  70                  75                  80  


Ala Val Ala Gly Met Pro Gly Gly Ser Ala Gly Ala Met Asn Ser Met 
                85                  90                  95      


Thr Ala Ala Gly Val Thr Ala Met Gly Thr Ala Leu Ser Pro Ser Gly 
            100                 105                 110         


Met Gly Ala Met Gly Ala Gln Gln Ala Ala Ser Met Asn Gly Leu Gly 
        115                 120                 125             


Pro Tyr Ala Ala Ala Met Asn Pro Cys Met Ser Pro Met Ala Tyr Ala 
    130                 135                 140                 


Pro Ser Asn Leu Gly Arg Ser Arg Ala Gly Gly Gly Gly Asp Ala Lys 
145                 150                 155                 160 


Thr Phe Lys Arg Ser Tyr Pro His Ala Lys Pro Pro Tyr Ser Tyr Ile 
                165                 170                 175     


Ser Leu Ile Thr Met Ala Ile Gln Gln Ala Pro Ser Lys Met Leu Thr 
            180                 185                 190         


Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu Phe Pro Tyr Tyr Arg 
        195                 200                 205             


Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe 
    210                 215                 220                 


Asn Asp Cys Phe Val Lys Val Ala Arg Ser Pro Asp Lys Pro Gly Lys 
225                 230                 235                 240 


Gly Ser Tyr Trp Thr Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn 
                245                 250                 255     


Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln Pro 
            260                 265                 270         


Gly Ala Gly Gly Gly Gly Gly Ser Gly Ser Gly Gly Ser Gly Ala Lys 
        275                 280                 285             


Gly Gly Pro Glu Ser Arg Lys Asp Pro Ser Gly Ala Ser Asn Pro Ser 
    290                 295                 300                 


Ala Asp Ser Pro Leu His Arg Gly Val His Gly Lys Thr Gly Gln Leu 
305                 310                 315                 320 


Glu Gly Ala Pro Ala Pro Gly Pro Ala Ala Ser Pro Gln Thr Leu Asp 
                325                 330                 335     


His Ser Gly Ala Thr Ala Thr Gly Gly Ala Ser Glu Leu Lys Thr Pro 
            340                 345                 350         


Ala Ser Ser Thr Ala Pro Pro Ile Ser Ser Gly Pro Gly Ala Leu Ala 
        355                 360                 365             


Ser Val Pro Ala Ser His Pro Ala His Gly Leu Ala Pro His Glu Ser 
    370                 375                 380                 


Gln Leu His Leu Lys Gly Asp Pro His Tyr Ser Phe Asn His Pro Phe 
385                 390                 395                 400 


Ser Ile Asn Asn Leu Met Ser Ser Ser Glu Gln Gln His Lys Leu Asp 
                405                 410                 415     


Phe Lys Ala Tyr Glu Gln Ala Leu Gln Tyr Ser Pro Tyr Gly Ser Thr 
            420                 425                 430         


Leu Pro Ala Ser Leu Pro Leu Gly Ser Ala Ser Val Thr Thr Arg Ser 
        435                 440                 445             


Pro Ile Glu Pro Ser Ala Leu Glu Pro Ala Tyr Tyr Gln Gly Val Tyr 
    450                 455                 460                 


Ser Arg Pro Val Leu Asn Thr Ser 
465                 470         


<210>  38
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       FOXA2

<400>  38

Met His Ser Ala Ser Ser Met Leu Gly Ala Val Lys Met Glu Gly His 
1               5                   10                  15      


Glu Pro Ser Asp Trp Ser Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser 
            20                  25                  30          


Ser Val Ser Asn Met Asn Ala Gly Leu Gly Met Asn Gly Met Asn Thr 
        35                  40                  45              


Tyr Met Ser Met Ser Ala Ala Ala Met Gly Ser Gly Ser Gly Asn Met 
    50                  55                  60                  


Ser Ala Gly Ser Met Asn Met Ser Ser Tyr Val Gly Ala Gly Met Ser 
65                  70                  75                  80  


Pro Ser Leu Ala Gly Met Ser Pro Gly Ala Gly Ala Met Ala Gly Met 
                85                  90                  95      


Gly Gly Ser Ala Gly Ala Ala Gly Val Ala Gly Met Gly Pro His Leu 
            100                 105                 110         


Ser Pro Ser Leu Ser Pro Leu Gly Gly Gln Ala Ala Gly Ala Met Gly 
        115                 120                 125             


Gly Leu Ala Pro Tyr Ala Asn Met Asn Ser Met Ser Pro Met Tyr Gly 
    130                 135                 140                 


Gln Ala Gly Leu Ser Arg Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser 
145                 150                 155                 160 


Tyr Thr His Ala Lys Pro Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met 
                165                 170                 175     


Ala Ile Gln Gln Ser Pro Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr 
            180                 185                 190         


Gln Trp Ile Met Asp Leu Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg 
        195                 200                 205             


Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe Asn Asp Cys Phe Leu 
    210                 215                 220                 


Lys Val Pro Arg Ser Pro Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr 
225                 230                 235                 240 


Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg 
                245                 250                 255     


Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala 
            260                 265                 270         


Ala Gly Ala Ala Gly Ser Gly Lys Lys Ala Ala Ala Gly Ala Gln Ala 
        275                 280                 285             


Ser Gln Ala Gln Leu Gly Glu Ala Ala Gly Pro Ala Ser Glu Thr Pro 
    290                 295                 300                 


Ala Gly Thr Glu Ser Pro His Ser Ser Ala Ser Pro Cys Gln Glu His 
305                 310                 315                 320 


Lys Arg Gly Gly Leu Gly Glu Leu Lys Gly Thr Pro Ala Ala Ala Leu 
                325                 330                 335     


Ser Pro Pro Glu Pro Ala Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala 
            340                 345                 350         


Ala His Leu Leu Gly Pro Pro His His Pro Gly Leu Pro Pro Glu Ala 
        355                 360                 365             


His Leu Lys Pro Glu His His Tyr Ala Phe Asn His Pro Phe Ser Ile 
    370                 375                 380                 


Asn Asn Leu Met Ser Ser Glu Gln Gln His His His Ser His His His 
385                 390                 395                 400 


His Gln Pro His Lys Met Asp Leu Lys Ala Tyr Glu Gln Val Met His 
                405                 410                 415     


Tyr Pro Gly Tyr Gly Ser Pro Met Pro Gly Ser Leu Ala Met Gly Pro 
            420                 425                 430         


Val Thr Asn Lys Thr Gly Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr 
        435                 440                 445             


Ser Tyr Tyr Gln Gly Val Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455                 460             


<210>  39
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, ELK1

<400>  39

Met Asp Pro Ser Val Thr Leu Trp Gln Phe Leu Leu Gln Leu Leu Arg 
1               5                   10                  15      


Glu Gln Gly Asn Gly His Ile Ile Ser Trp Thr Ser Arg Asp Gly Gly 
            20                  25                  30          


Glu Phe Lys Leu Val Asp Ala Glu Glu Val Ala Arg Leu Trp Gly Leu 
        35                  40                  45              


Arg Lys Asn Lys Thr Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu 
    50                  55                  60                  


Arg Tyr Tyr Tyr Asp Lys Asn Ile Ile Arg Lys Val Ser Gly Gln Lys 
65                  70                  75                  80  


Phe Val Tyr Lys Phe Val Ser Tyr Pro Glu Val Ala Gly Cys Ser Thr 
                85                  90                  95      


Glu Asp Cys Pro Pro Gln Pro Glu Val Ser Val Thr Ser Thr Met Pro 
            100                 105                 110         


Asn Val Ala Pro Ala Ala Ile His Ala Ala Pro Gly Asp Thr Val Ser 
        115                 120                 125             


Gly Lys Pro Gly Thr Pro Lys Gly Ala Gly Met Ala Gly Pro Gly Gly 
    130                 135                 140                 


Leu Ala Arg Ser Ser Arg Asn Glu Tyr Met Arg Ser Gly Leu Tyr Ser 
145                 150                 155                 160 


Thr Phe Thr Ile Gln Ser Leu Gln Pro Gln Pro Pro Pro His Pro Arg 
                165                 170                 175     


Pro Ala Val Val Leu Pro Ser Ala Ala Pro Ala Gly Ala Ala Ala Pro 
            180                 185                 190         


Pro Ser Gly Ser Arg Ser Thr Ser Pro Ser Pro Leu Glu Ala Cys Leu 
        195                 200                 205             


Glu Ala Glu Glu Ala Gly Leu Pro Leu Gln Val Ile Leu Thr Pro Pro 
    210                 215                 220                 


Glu Ala Pro Asn Leu Lys Ser Glu Glu Leu Asn Val Glu Pro Gly Leu 
225                 230                 235                 240 


Gly Arg Ala Leu Pro Pro Glu Val Lys Val Glu Gly Pro Lys Glu Glu 
                245                 250                 255     


Leu Glu Val Ala Gly Glu Arg Gly Phe Val Pro Glu Thr Thr Lys Ala 
            260                 265                 270         


Glu Pro Glu Val Pro Pro Gln Glu Gly Val Pro Ala Arg Leu Pro Ala 
        275                 280                 285             


Val Val Met Asp Thr Ala Gly Gln Ala Gly Gly His Ala Ala Ser Ser 
    290                 295                 300                 


Pro Glu Ile Ser Gln Pro Gln Lys Gly Arg Lys Pro Arg Asp Leu Glu 
305                 310                 315                 320 


Leu Pro Leu Ser Pro Ser Leu Leu Gly Gly Pro Gly Pro Glu Arg Thr 
                325                 330                 335     


Pro Gly Ser Gly Ser Gly Ser Gly Leu Gln Ala Pro Gly Pro Ala Leu 
            340                 345                 350         


Thr Pro Ser Leu Leu Pro Thr His Thr Leu Thr Pro Val Leu Leu Thr 
        355                 360                 365             


Pro Ser Ser Leu Pro Pro Ser Ile His Phe Trp Ser Thr Leu Ser Pro 
    370                 375                 380                 


Ile Ala Pro Arg Ser Pro Ala Lys Leu Ser Phe Gln Phe Pro Ser Ser 
385                 390                 395                 400 


Gly Ser Ala Gln Val His Ile Pro Ser Ile Ser Val Asp Gly Leu Ser 
                405                 410                 415     


Thr Pro Val Val Leu Ser Pro Gly Pro Gln Lys Pro 
            420                 425             


<210>  40
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, ELK3

<400>  40

Met Glu Ser Ala Ile Thr Leu Trp Gln Phe Leu Leu Gln Leu Leu Leu 
1               5                   10                  15      


Asp Gln Lys His Glu His Leu Ile Cys Trp Thr Ser Asn Asp Gly Glu 
            20                  25                  30          


Phe Lys Leu Leu Lys Ala Glu Glu Val Ala Lys Leu Trp Gly Leu Arg 
        35                  40                  45              


Lys Asn Lys Thr Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg 
    50                  55                  60                  


Tyr Tyr Tyr Asp Lys Asn Ile Ile Lys Lys Val Ile Gly Gln Lys Phe 
65                  70                  75                  80  


Val Tyr Lys Phe Val Ser Phe Pro Glu Ile Leu Lys Met Asp Pro His 
                85                  90                  95      


Ala Val Glu Ile Ser Arg Glu Ser Leu Leu Leu Gln Asp Ser Asp Cys 
            100                 105                 110         


Lys Ala Ser Pro Glu Gly Arg Glu Ala His Lys His Gly Leu Ala Ala 
        115                 120                 125             


Leu Arg Ser Thr Ser Arg Asn Glu Tyr Ile His Ser Gly Leu Tyr Ser 
    130                 135                 140                 


Ser Phe Thr Ile Asn Ser Leu Gln Asn Pro Pro Asp Ala Phe Lys Ala 
145                 150                 155                 160 


Ile Lys Thr Glu Lys Leu Glu Glu Pro Pro Glu Asp Ser Pro Pro Val 
                165                 170                 175     


Glu Glu Val Arg Thr Val Ile Arg Phe Val Thr Asn Lys Thr Asp Lys 
            180                 185                 190         


His Val Thr Arg Pro Val Val Ser Leu Pro Ser Thr Ser Glu Ala Ala 
        195                 200                 205             


Ala Ala Ser Ala Phe Leu Ala Ser Ser Val Ser Ala Lys Ile Ser Ser 
    210                 215                 220                 


Leu Met Leu Pro Asn Ala Ala Ser Ile Ser Ser Ala Ser Pro Phe Ser 
225                 230                 235                 240 


Ser Arg Ser Pro Ser Leu Ser Pro Asn Ser Pro Leu Pro Ser Glu His 
                245                 250                 255     


Arg Ser Leu Phe Leu Glu Ala Ala Cys His Asp Ser Asp Ser Leu Glu 
            260                 265                 270         


Pro Leu Asn Leu Ser Ser Gly Ser Lys Thr Lys Ser Pro Ser Leu Pro 
        275                 280                 285             


Pro Lys Ala Lys Lys Pro Lys Gly Leu Glu Ile Ser Ala Pro Pro Leu 
    290                 295                 300                 


Val Leu Ser Gly Thr Asp Ile Gly Ser Ile Ala Leu Asn Ser Pro Ala 
305                 310                 315                 320 


Leu Pro Ser Gly Ser Leu Thr Pro Ala Phe Phe Thr Ala Gln Thr Pro 
                325                 330                 335     


Asn Gly Leu Leu Leu Thr Pro Ser Pro Leu Leu Ser Ser Ile His Phe 
            340                 345                 350         


Trp Ser Ser Leu Ser Pro Val Ala Pro Leu Ser Pro Ala Arg Leu Gln 
        355                 360                 365             


Gly Pro Ser Thr Leu Phe Gln Phe Pro Thr Leu Leu Asn Gly His Met 
    370                 375                 380                 


Pro Val Pro Ile Pro Ser Leu Asp Arg Ala Ala Ser Pro Val Leu Leu 
385                 390                 395                 400 


Ser Ser Asn Ser Gln Lys Ser 
                405         


<210>  41
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, ELK4

<400>  41

Met Asp Ser Ala Ile Thr Leu Trp Gln Phe Leu Leu Gln Leu Leu Gln 
1               5                   10                  15      


Lys Pro Gln Asn Lys His Met Ile Cys Trp Thr Ser Asn Asp Gly Gln 
            20                  25                  30          


Phe Lys Leu Leu Gln Ala Glu Glu Val Ala Arg Leu Trp Gly Ile Arg 
        35                  40                  45              


Lys Asn Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg 
    50                  55                  60                  


Tyr Tyr Tyr Val Lys Asn Ile Ile Lys Lys Val Asn Gly Gln Lys Phe 
65                  70                  75                  80  


Val Tyr Lys Phe Val Ser Tyr Pro Glu Ile Leu Asn Met Asp Pro Met 
                85                  90                  95      


Thr Val Gly Arg Ile Glu Gly Asp Cys Glu Ser Leu Asn Phe Ser Glu 
            100                 105                 110         


Val Ser Ser Ser Ser Lys Asp Val Glu Asn Gly Gly Lys Asp Lys Pro 
        115                 120                 125             


Pro Gln Pro Gly Ala Lys Thr Ser Ser Arg Asn Asp Tyr Ile His Ser 
    130                 135                 140                 


Gly Leu Tyr Ser Ser Phe Thr Leu Asn Ser Leu Asn Ser Ser Asn Val 
145                 150                 155                 160 


Lys Leu Phe Lys Leu Ile Lys Thr Glu Asn Pro Ala Glu Lys Leu Ala 
                165                 170                 175     


Glu Lys Lys Ser Pro Gln Glu Pro Thr Pro Ser Val Ile Lys Phe Val 
            180                 185                 190         


Thr Thr Pro Ser Lys Lys Pro Pro Val Glu Pro Val Ala Ala Thr Ile 
        195                 200                 205             


Ser Ile Gly Pro Ser Ile Ser Pro Ser Ser Glu Glu Thr Ile Gln Ala 
    210                 215                 220                 


Leu Glu Thr Leu Val Ser Pro Lys Leu Pro Ser Leu Glu Ala Pro Thr 
225                 230                 235                 240 


Ser Ala Ser Asn Val Met Thr Ala Phe Ala Thr Thr Pro Pro Ile Ser 
                245                 250                 255     


Ser Ile Pro Pro Leu Gln Glu Pro Pro Arg Thr Pro Ser Pro Pro Leu 
            260                 265                 270         


Ser Ser His Pro Asp Ile Asp Thr Asp Ile Asp Ser Val Ala Ser Gln 
        275                 280                 285             


Pro Met Glu Leu Pro Glu Asn Leu Ser Leu Glu Pro Lys Asp Gln Asp 
    290                 295                 300                 


Ser Val Leu Leu Glu Lys Asp Lys Val Asn Asn Ser Ser Arg Ser Lys 
305                 310                 315                 320 


Lys Pro Lys Gly Leu Glu Leu Ala Pro Thr Leu Val Ile Thr Ser Ser 
                325                 330                 335     


Asp Pro Ser Pro Leu Gly Ile Leu Ser Pro Ser Leu Pro Thr Ala Ser 
            340                 345                 350         


Leu Thr Pro Ala Phe Phe Ser Gln Thr Pro Ile Ile Leu Thr Pro Ser 
        355                 360                 365             


Pro Leu Leu Ser Ser Ile His Phe Trp Ser Thr Leu Ser Pro Val Ala 
    370                 375                 380                 


Pro Leu Ser Pro Ala Arg Leu Gln Gly Ala Asn Thr Leu Phe Gln Phe 
385                 390                 395                 400 


Pro Ser Val Leu Asn Ser His Gly Pro Phe Thr Leu Ser Gly Leu Asp 
                405                 410                 415     


Gly Pro Ser Thr Pro Gly Pro Phe Ser Pro Asp Leu Gln Lys Thr 
            420                 425                 430     


<210>  42
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, SRF

<400>  42

Met Leu Pro Thr Gln Ala Gly Ala Ala Ala Ala Leu Gly Arg Gly Ser 
1               5                   10                  15      


Ala Leu Gly Gly Ser Leu Asn Arg Thr Pro Thr Gly Arg Pro Gly Gly 
            20                  25                  30          


Gly Gly Gly Thr Arg Gly Ala Asn Gly Gly Arg Val Pro Gly Asn Gly 
        35                  40                  45              


Ala Gly Leu Gly Pro Gly Arg Leu Glu Arg Glu Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Thr Thr Pro Ala Pro Thr Ala Gly Ala Leu Tyr Ser Gly Ser Glu 
65                  70                  75                  80  


Gly Asp Ser Glu Ser Gly Glu Glu Glu Glu Leu Gly Ala Glu Arg Arg 
                85                  90                  95      


Gly Leu Lys Arg Ser Leu Ser Glu Met Glu Ile Gly Met Val Val Gly 
            100                 105                 110         


Gly Pro Glu Ala Ser Ala Ala Ala Thr Gly Gly Tyr Gly Pro Val Ser 
        115                 120                 125             


Gly Ala Val Ser Gly Ala Lys Pro Gly Lys Lys Thr Arg Gly Arg Val 
    130                 135                 140                 


Lys Ile Lys Met Glu Phe Ile Asp Asn Lys Leu Arg Arg Tyr Thr Thr 
145                 150                 155                 160 


Phe Ser Lys Arg Lys Thr Gly Ile Met Lys Lys Ala Tyr Glu Leu Ser 
                165                 170                 175     


Thr Leu Thr Gly Thr Gln Val Leu Leu Leu Val Ala Ser Glu Thr Gly 
            180                 185                 190         


His Val Tyr Thr Phe Ala Thr Arg Lys Leu Gln Pro Met Ile Thr Ser 
        195                 200                 205             


Glu Thr Gly Lys Ala Leu Ile Gln Thr Cys Leu Asn Ser Pro Asp Ser 
    210                 215                 220                 


Pro Pro Arg Ser Asp Pro Thr Thr Asp Gln Arg Met Ser Ala Thr Gly 
225                 230                 235                 240 


Phe Glu Glu Thr Asp Leu Thr Tyr Gln Val Ser Glu Ser Asp Ser Ser 
                245                 250                 255     


Gly Glu Thr Lys Asp Thr Leu Lys Pro Ala Phe Thr Val Thr Asn Leu 
            260                 265                 270         


Pro Gly Thr Thr Ser Thr Ile Gln Thr Ala Pro Ser Thr Ser Thr Thr 
        275                 280                 285             


Met Gln Val Ser Ser Gly Pro Ser Phe Pro Ile Thr Asn Tyr Leu Ala 
    290                 295                 300                 


Pro Val Ser Ala Ser Val Ser Pro Ser Ala Val Ser Ser Ala Asn Gly 
305                 310                 315                 320 


Thr Val Leu Lys Ser Thr Gly Ser Gly Pro Val Ser Ser Gly Gly Leu 
                325                 330                 335     


Met Gln Leu Pro Thr Ser Phe Thr Leu Met Pro Gly Gly Ala Val Ala 
            340                 345                 350         


Gln Gln Val Pro Val Gln Ala Ile Gln Val His Gln Ala Pro Gln Gln 
        355                 360                 365             


Ala Ser Pro Ser Arg Asp Ser Ser Thr Asp Leu Thr Gln Thr Ser Ser 
    370                 375                 380                 


Ser Gly Thr Val Thr Leu Pro Ala Thr Ile Met Thr Ser Ser Val Pro 
385                 390                 395                 400 


Thr Thr Val Gly Gly His Met Met Tyr Pro Ser Pro His Ala Val Met 
                405                 410                 415     


Tyr Ala Pro Thr Ser Gly Leu Gly Asp Gly Ser Leu Thr Val Leu Asn 
            420                 425                 430         


Ala Phe Ser Gln Ala Pro Ser Thr Met Gln Val Ser His Ser Gln Val 
        435                 440                 445             


Gln Glu Pro Gly Gly Val Pro Gln Val Phe Leu Thr Ala Ser Ser Gly 
    450                 455                 460                 


Thr Val Gln Ile Pro Val Ser Ala Val Gln Leu His Gln Met Ala Val 
465                 470                 475                 480 


Ile Gly Gln Gln Ala Gly Ser Ser Ser Asn Leu Thr Glu Leu Gln Val 
                485                 490                 495     


Val Asn Leu Asp Thr Ala His Ser Thr Lys Ser Glu 
            500                 505             


<210>  43
<211>  801
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       FOXM1

<400>  43

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr 
                165                 170                 175     


Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser 
            180                 185                 190         


Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu 
        195                 200                 205             


Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg 
    210                 215                 220                 


Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser 
225                 230                 235                 240 


Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg 
                245                 250                 255     


Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr 
            260                 265                 270         


Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn 
        275                 280                 285             


Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys 
    290                 295                 300                 


Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu 
305                 310                 315                 320 


Asp Gln Val Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu 
                325                 330                 335     


His Leu Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn 
            340                 345                 350         


Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys 
        355                 360                 365             


Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro 
    370                 375                 380                 


Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro 
385                 390                 395                 400 


Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg 
                405                 410                 415     


Val Arg Ile Ala Pro Lys Val Phe Gly Glu Gln Val Val Phe Gly Tyr 
            420                 425                 430         


Met Ser Lys Phe Phe Ser Gly Asp Leu Arg Asp Phe Gly Thr Pro Ile 
        435                 440                 445             


Thr Ser Leu Phe Asn Phe Ile Phe Leu Cys Leu Ser Val Leu Leu Ala 
    450                 455                 460                 


Glu Glu Gly Ile Ala Pro Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu 
465                 470                 475                 480 


Lys Leu Leu Phe Gly Glu Gly Phe Ser Pro Leu Leu Pro Val Gln Thr 
                485                 490                 495     


Ile Lys Glu Glu Glu Ile Gln Pro Gly Glu Glu Met Pro His Leu Ala 
            500                 505                 510         


Arg Pro Ile Lys Val Glu Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro 
        515                 520                 525             


Ala Pro Ser Phe Lys Glu Glu Ser Ser His Ser Trp Glu Asp Ser Ser 
    530                 535                 540                 


Gln Ser Pro Thr Pro Arg Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser 
545                 550                 555                 560 


Pro Thr Arg Cys Val Ser Glu Met Leu Val Ile Gln His Arg Glu Arg 
                565                 570                 575     


Arg Glu Arg Ser Arg Ser Arg Arg Lys Gln His Leu Leu Pro Pro Cys 
            580                 585                 590         


Val Asp Glu Pro Glu Leu Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg 
        595                 600                 605             


Trp Ala Ala Glu Leu Pro Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser 
    610                 615                 620                 


Gln Leu Ser Tyr Ser Gln Glu Val Gly Gly Pro Phe Lys Thr Pro Ile 
625                 630                 635                 640 


Lys Glu Thr Leu Pro Ile Ser Ser Thr Pro Ser Lys Ser Val Leu Pro 
                645                 650                 655     


Arg Thr Pro Glu Ser Trp Arg Leu Thr Pro Pro Ala Lys Val Gly Gly 
            660                 665                 670         


Leu Asp Phe Ser Pro Val Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu 
        675                 680                 685             


Pro Asp Pro Leu Gly Leu Met Asp Leu Ser Thr Thr Pro Leu Gln Ser 
    690                 695                 700                 


Ala Pro Pro Leu Glu Ser Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu 
705                 710                 715                 720 


Asp Leu Ile Ser Val Pro Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp 
                725                 730                 735     


Val Pro Lys Pro Gly Ser Pro Glu Pro Gln Val Ser Gly Leu Ala Ala 
            740                 745                 750         


Asn Arg Ser Leu Thr Glu Gly Leu Val Leu Asp Thr Met Asn Asp Ser 
        755                 760                 765             


Leu Ser Lys Ile Leu Leu Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp 
    770                 775                 780                 


Pro Leu Gly Pro Asp Asn Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu 
785                 790                 795                 800 


Gln 
    


<210>  44
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       FOXC1

<400>  44

Met Gln Ala Arg Tyr Ser Val Ser Ser Pro Asn Ser Leu Gly Val Val 
1               5                   10                  15      


Pro Tyr Leu Gly Gly Glu Gln Ser Tyr Tyr Arg Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Gly Gly Gly Tyr Thr Ala Met Pro Ala Pro Met Ser Val Tyr Ser 
        35                  40                  45              


His Pro Ala His Ala Glu Gln Tyr Pro Gly Gly Met Ala Arg Ala Tyr 
    50                  55                  60                  


Gly Pro Tyr Thr Pro Gln Pro Gln Pro Lys Asp Met Val Lys Pro Pro 
65                  70                  75                  80  


Tyr Ser Tyr Ile Ala Leu Ile Thr Met Ala Ile Gln Asn Ala Pro Asp 
                85                  90                  95      


Lys Lys Ile Thr Leu Asn Gly Ile Tyr Gln Phe Ile Met Asp Arg Phe 
            100                 105                 110         


Pro Phe Tyr Arg Asp Asn Lys Gln Gly Trp Gln Asn Ser Ile Arg His 
        115                 120                 125             


Asn Leu Ser Leu Asn Glu Cys Phe Val Lys Val Pro Arg Asp Asp Lys 
    130                 135                 140                 


Lys Pro Gly Lys Gly Ser Tyr Trp Thr Leu Asp Pro Asp Ser Tyr Asn 
145                 150                 155                 160 


Met Phe Glu Asn Gly Ser Phe Leu Arg Arg Arg Arg Arg Phe Lys Lys 
                165                 170                 175     


Lys Asp Ala Val Lys Asp Lys Glu Glu Lys Asp Arg Leu His Leu Lys 
            180                 185                 190         


Glu Pro Pro Pro Pro Gly Arg Gln Pro Pro Pro Ala Pro Pro Glu Gln 
        195                 200                 205             


Ala Asp Gly Asn Ala Pro Gly Pro Gln Pro Pro Pro Val Arg Ile Gln 
    210                 215                 220                 


Asp Ile Lys Thr Glu Asn Gly Thr Cys Pro Ser Pro Pro Gln Pro Leu 
225                 230                 235                 240 


Ser Pro Ala Ala Ala Leu Gly Ser Gly Ser Ala Ala Ala Val Pro Lys 
                245                 250                 255     


Ile Glu Ser Pro Asp Ser Ser Ser Ser Ser Leu Ser Ser Gly Ser Ser 
            260                 265                 270         


Pro Pro Gly Ser Leu Pro Ser Ala Arg Pro Leu Ser Leu Asp Gly Ala 
        275                 280                 285             


Asp Ser Ala Pro Pro Pro Pro Ala Pro Ser Ala Pro Pro Pro His His 
    290                 295                 300                 


Ser Gln Gly Phe Ser Val Asp Asn Ile Met Thr Ser Leu Arg Gly Ser 
305                 310                 315                 320 


Pro Gln Ser Ala Ala Ala Glu Leu Ser Ser Gly Leu Leu Ala Ser Ala 
                325                 330                 335     


Ala Ala Ser Ser Arg Ala Gly Ile Ala Pro Pro Leu Ala Leu Gly Ala 
            340                 345                 350         


Tyr Ser Pro Gly Gln Ser Ser Leu Tyr Ser Ser Pro Cys Ser Gln Thr 
        355                 360                 365             


Ser Ser Ala Gly Ser Ser Gly Gly Gly Gly Gly Gly Ala Gly Ala Ala 
    370                 375                 380                 


Gly Gly Ala Gly Gly Ala Gly Thr Tyr His Cys Asn Leu Gln Ala Met 
385                 390                 395                 400 


Ser Leu Tyr Ala Ala Gly Glu Arg Gly Gly His Leu Gln Gly Ala Pro 
                405                 410                 415     


Gly Gly Ala Gly Gly Ser Ala Val Asp Asp Pro Leu Pro Asp Tyr Ser 
            420                 425                 430         


Leu Pro Pro Val Thr Ser Ser Ser Ser Ser Ser Leu Ser His Gly Gly 
        435                 440                 445             


Gly Gly Gly Gly Gly Gly Gly Gly Gln Glu Ala Gly His His Pro Ala 
    450                 455                 460                 


Ala His Gln Gly Arg Leu Thr Ser Trp Tyr Leu Asn Gln Ala Gly Gly 
465                 470                 475                 480 


Asp Leu Gly His Leu Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly 
                485                 490                 495     


Tyr Pro Gly Gln Gln Gln Asn Phe His Ser Val Arg Glu Met Phe Glu 
            500                 505                 510         


Ser Gln Arg Ile Gly Leu Asn Asn Ser Pro Val Asn Gly Asn Ser Ser 
        515                 520                 525             


Cys Gln Met Ala Phe Pro Ser Ser Gln Ser Leu Tyr Arg Thr Ser Gly 
    530                 535                 540                 


Ala Phe Val Tyr Asp Cys Ser Lys Phe 
545                 550             


<210>  45
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       FOXC2

<400>  45

Met Gln Ala Arg Tyr Ser Val Ser Asp Pro Asn Ala Leu Gly Val Val 
1               5                   10                  15      


Pro Tyr Leu Ser Glu Gln Asn Tyr Tyr Arg Ala Ala Gly Ser Tyr Gly 
            20                  25                  30          


Gly Met Ala Ser Pro Met Gly Val Tyr Ser Gly His Pro Glu Gln Tyr 
        35                  40                  45              


Ser Ala Gly Met Gly Arg Ser Tyr Ala Pro Tyr His His His Gln Pro 
    50                  55                  60                  


Ala Ala Pro Lys Asp Leu Val Lys Pro Pro Tyr Ser Tyr Ile Ala Leu 
65                  70                  75                  80  


Ile Thr Met Ala Ile Gln Asn Ala Pro Glu Lys Lys Ile Thr Leu Asn 
                85                  90                  95      


Gly Ile Tyr Gln Phe Ile Met Asp Arg Phe Pro Phe Tyr Arg Glu Asn 
            100                 105                 110         


Lys Gln Gly Trp Gln Asn Ser Ile Arg His Asn Leu Ser Leu Asn Glu 
        115                 120                 125             


Cys Phe Val Lys Val Pro Arg Asp Asp Lys Lys Pro Gly Lys Gly Ser 
    130                 135                 140                 


Tyr Trp Thr Leu Asp Pro Asp Ser Tyr Asn Met Phe Glu Asn Gly Ser 
145                 150                 155                 160 


Phe Leu Arg Arg Arg Arg Arg Phe Lys Lys Lys Asp Val Ser Lys Glu 
                165                 170                 175     


Lys Glu Glu Arg Ala His Leu Lys Glu Pro Pro Pro Ala Ala Ser Lys 
            180                 185                 190         


Gly Ala Pro Ala Thr Pro His Leu Ala Asp Ala Pro Lys Glu Ala Glu 
        195                 200                 205             


Lys Lys Val Val Ile Lys Ser Glu Ala Ala Ser Pro Ala Leu Pro Val 
    210                 215                 220                 


Ile Thr Lys Val Glu Thr Leu Ser Pro Glu Ser Ala Leu Gln Gly Ser 
225                 230                 235                 240 


Pro Arg Ser Ala Ala Ser Thr Pro Ala Gly Ser Pro Asp Gly Ser Leu 
                245                 250                 255     


Pro Glu His His Ala Ala Ala Pro Asn Gly Leu Pro Gly Phe Ser Val 
            260                 265                 270         


Glu Asn Ile Met Thr Leu Arg Thr Ser Pro Pro Gly Gly Glu Leu Ser 
        275                 280                 285             


Pro Gly Ala Gly Arg Ala Gly Leu Val Val Pro Pro Leu Ala Leu Pro 
    290                 295                 300                 


Tyr Ala Ala Ala Pro Pro Ala Ala Tyr Gly Gln Pro Cys Ala Gln Gly 
305                 310                 315                 320 


Leu Glu Ala Gly Ala Ala Gly Gly Tyr Gln Cys Ser Met Arg Ala Met 
                325                 330                 335     


Ser Leu Tyr Thr Gly Ala Glu Arg Pro Ala His Met Cys Val Pro Pro 
            340                 345                 350         


Ala Leu Asp Glu Ala Leu Ser Asp His Pro Ser Gly Pro Thr Ser Pro 
        355                 360                 365             


Leu Ser Ala Leu Asn Leu Ala Ala Gly Gln Glu Gly Ala Leu Ala Ala 
    370                 375                 380                 


Thr Gly His His His Gln His His Gly His His His Pro Gln Ala Pro 
385                 390                 395                 400 


Pro Pro Pro Pro Ala Pro Gln Pro Gln Pro Thr Pro Gln Pro Gly Ala 
                405                 410                 415     


Ala Ala Ala Gln Ala Ala Ser Trp Tyr Leu Asn His Ser Gly Asp Leu 
            420                 425                 430         


Asn His Leu Pro Gly His Thr Phe Ala Ala Gln Gln Gln Thr Phe Pro 
        435                 440                 445             


Asn Val Arg Glu Met Phe Asn Ser His Arg Leu Gly Ile Glu Asn Ser 
    450                 455                 460                 


Thr Leu Gly Glu Ser Gln Val Ser Gly Asn Ala Ser Cys Gln Leu Pro 
465                 470                 475                 480 


Tyr Arg Ser Thr Pro Pro Leu Tyr Arg His Ala Ala Pro Tyr Ser Tyr 
                485                 490                 495     


Asp Cys Thr Lys Tyr 
            500     


<210>  46
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       TWIST1

<400>  46

Met Met Gln Asp Val Ser Ser Ser Pro Val Ser Pro Ala Asp Asp Ser 
1               5                   10                  15      


Leu Ser Asn Ser Glu Glu Glu Pro Asp Arg Gln Gln Pro Pro Ser Gly 
            20                  25                  30          


Lys Arg Gly Gly Arg Lys Arg Arg Ser Ser Arg Arg Ser Ala Gly Gly 
        35                  40                  45              


Gly Ala Gly Pro Gly Gly Ala Ala Gly Gly Gly Val Gly Gly Gly Asp 
    50                  55                  60                  


Glu Pro Gly Ser Pro Ala Gln Gly Lys Arg Gly Lys Lys Ser Ala Gly 
65                  70                  75                  80  


Cys Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Ser Ser Ser Gly 
                85                  90                  95      


Gly Gly Ser Pro Gln Ser Tyr Glu Glu Leu Gln Thr Gln Arg Val Met 
            100                 105                 110         


Ala Asn Val Arg Glu Arg Gln Arg Thr Gln Ser Leu Asn Glu Ala Phe 
        115                 120                 125             


Ala Ala Leu Arg Lys Ile Ile Pro Thr Leu Pro Ser Asp Lys Leu Ser 
    130                 135                 140                 


Lys Ile Gln Thr Leu Lys Leu Ala Ala Arg Tyr Ile Asp Phe Leu Tyr 
145                 150                 155                 160 


Gln Val Leu Gln Ser Asp Glu Leu Asp Ser Lys Met Ala Ser Cys Ser 
                165                 170                 175     


Tyr Val Ala His Glu Arg Leu Ser Tyr Ala Phe Ser Val Trp Arg Met 
            180                 185                 190         


Glu Gly Ala Trp Ser Met Ser Ala Ser His 
        195                 200         


<210>  47
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       HIF1A

<400>  47

Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu 
1               5                   10                  15      


Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys 
            20                  25                  30          


Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His 
        35                  40                  45              


Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile 
    50                  55                  60                  


Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile 
65                  70                  75                  80  


Glu Asp Asp Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu 
                85                  90                  95      


Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile 
            100                 105                 110         


Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr 
        115                 120                 125             


Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met 
    130                 135                 140                 


Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu 
145                 150                 155                 160 


Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                165                 170                 175     


Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
            180                 185                 190         


His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro 
        195                 200                 205             


Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys 
    210                 215                 220                 


Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys 
225                 230                 235                 240 


Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                245                 250                 255     


Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly 
            260                 265                 270         


Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
        275                 280                 285             


Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln 
    290                 295                 300                 


Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln 
305                 310                 315                 320 


Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val 
                325                 330                 335     


Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe 
            340                 345                 350         


Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp 
        355                 360                 365             


Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu 
385                 390                 395                 400 


Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn 
                405                 410                 415     


Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn 
            420                 425                 430         


Asp Val Met Leu Pro Ser Pro Asn Glu Lys Leu Gln Asn Ile Asn Leu 
        435                 440                 445             


Ala Met Ser Pro Leu Pro Thr Ala Glu Thr Pro Lys Pro Leu Arg Ser 
    450                 455                 460                 


Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro 
465                 470                 475                 480 


Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp 
                485                 490                 495     


Gln Thr Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu 
            500                 505                 510         


Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val 
        515                 520                 525             


Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr 
    530                 535                 540                 


Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu 
545                 550                 555                 560 


Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser 
                565                 570                 575     


Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser 
            580                 585                 590         


Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln 
        595                 600                 605             


Glu Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu 
    610                 615                 620                 


Lys Thr Val Thr Lys Asp Arg Met Glu Asp Ile Lys Ile Leu Ile Ala 
625                 630                 635                 640 


Ser Pro Ser Pro Thr His Ile His Lys Glu Thr Thr Ser Ala Thr Ser 
                645                 650                 655     


Ser Pro Tyr Arg Asp Thr Gln Ser Arg Thr Ala Ser Pro Asn Arg Ala 
            660                 665                 670         


Gly Lys Gly Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro 
        675                 680                 685             


Asn Val Leu Ser Val Ala Leu Ser Gln Arg Thr Thr Val Pro Glu Glu 
    690                 695                 700                 


Glu Leu Asn Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg 
705                 710                 715                 720 


Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Ile 
                725                 730                 735 


<210>  48
<211>  1053
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       SALL4

<400>  48

Met Ser Arg Arg Lys Gln Ala Lys Pro Gln His Ile Asn Ser Glu Glu 
1               5                   10                  15      


Asp Gln Gly Glu Gln Gln Pro Gln Gln Gln Thr Pro Glu Phe Ala Asp 
            20                  25                  30          


Ala Ala Pro Ala Ala Pro Ala Ala Gly Glu Leu Gly Ala Pro Val Asn 
        35                  40                  45              


His Pro Gly Asn Asp Glu Val Ala Ser Glu Asp Glu Ala Thr Val Lys 
    50                  55                  60                  


Arg Leu Arg Arg Glu Glu Thr His Val Cys Glu Lys Cys Cys Ala Glu 
65                  70                  75                  80  


Phe Phe Ser Ile Ser Glu Phe Leu Glu His Lys Lys Asn Cys Thr Lys 
                85                  90                  95      


Asn Pro Pro Val Leu Ile Met Asn Asp Ser Glu Gly Pro Val Pro Ser 
            100                 105                 110         


Glu Asp Phe Ser Gly Ala Val Leu Ser His Gln Pro Thr Ser Pro Gly 
        115                 120                 125             


Ser Lys Asp Cys His Arg Glu Asn Gly Gly Ser Ser Glu Asp Met Lys 
    130                 135                 140                 


Glu Lys Pro Asp Ala Glu Ser Val Val Tyr Leu Lys Thr Glu Thr Ala 
145                 150                 155                 160 


Leu Pro Pro Thr Pro Gln Asp Ile Ser Tyr Leu Ala Lys Gly Lys Val 
                165                 170                 175     


Ala Asn Thr Asn Val Thr Leu Gln Ala Leu Arg Gly Thr Lys Val Ala 
            180                 185                 190         


Val Asn Gln Arg Ser Ala Asp Ala Leu Pro Ala Pro Val Pro Gly Ala 
        195                 200                 205             


Asn Ser Ile Pro Trp Val Leu Glu Gln Ile Leu Cys Leu Gln Gln Gln 
    210                 215                 220                 


Gln Leu Gln Gln Ile Gln Leu Thr Glu Gln Ile Arg Ile Gln Val Asn 
225                 230                 235                 240 


Met Trp Ala Ser His Ala Leu His Ser Ser Gly Ala Gly Ala Asp Thr 
                245                 250                 255     


Leu Lys Thr Leu Gly Ser His Met Ser Gln Gln Val Ser Ala Ala Val 
            260                 265                 270         


Ala Leu Leu Ser Gln Lys Ala Gly Ser Gln Gly Leu Ser Leu Asp Ala 
        275                 280                 285             


Leu Lys Gln Ala Lys Leu Pro His Ala Asn Ile Pro Ser Ala Thr Ser 
    290                 295                 300                 


Ser Leu Ser Pro Gly Leu Ala Pro Phe Thr Leu Lys Pro Asp Gly Thr 
305                 310                 315                 320 


Arg Val Leu Pro Asn Val Met Ser Arg Leu Pro Ser Ala Leu Leu Pro 
                325                 330                 335     


Gln Ala Pro Gly Ser Val Leu Phe Gln Ser Pro Phe Ser Thr Val Ala 
            340                 345                 350         


Leu Asp Thr Ser Lys Lys Gly Lys Gly Lys Pro Pro Asn Ile Ser Ala 
        355                 360                 365             


Val Asp Val Lys Pro Lys Asp Glu Ala Ala Leu Tyr Lys His Lys Cys 
    370                 375                 380                 


Lys Tyr Cys Ser Lys Val Phe Gly Thr Asp Ser Ser Leu Gln Ile His 
385                 390                 395                 400 


Leu Arg Ser His Thr Gly Glu Arg Pro Phe Val Cys Ser Val Cys Gly 
                405                 410                 415     


His Arg Phe Thr Thr Lys Gly Asn Leu Lys Val His Phe His Arg His 
            420                 425                 430         


Pro Gln Val Lys Ala Asn Pro Gln Leu Phe Ala Glu Phe Gln Asp Lys 
        435                 440                 445             


Val Ala Ala Gly Asn Gly Ile Pro Tyr Ala Leu Ser Val Pro Asp Pro 
    450                 455                 460                 


Ile Asp Glu Pro Ser Leu Ser Leu Asp Ser Lys Pro Val Leu Val Thr 
465                 470                 475                 480 


Thr Ser Val Gly Leu Pro Gln Asn Leu Ser Ser Gly Thr Asn Pro Lys 
                485                 490                 495     


Asp Leu Thr Gly Gly Ser Leu Pro Gly Asp Leu Gln Pro Gly Pro Ser 
            500                 505                 510         


Pro Glu Ser Glu Gly Gly Pro Thr Leu Pro Gly Val Gly Pro Asn Tyr 
        515                 520                 525             


Asn Ser Pro Arg Ala Gly Gly Phe Gln Gly Ser Gly Thr Pro Glu Pro 
    530                 535                 540                 


Gly Ser Glu Thr Leu Lys Leu Gln Gln Leu Val Glu Asn Ile Asp Lys 
545                 550                 555                 560 


Ala Thr Thr Asp Pro Asn Glu Cys Leu Ile Cys His Arg Val Leu Ser 
                565                 570                 575     


Cys Gln Ser Ser Leu Lys Met His Tyr Arg Thr His Thr Gly Glu Arg 
            580                 585                 590         


Pro Phe Gln Cys Lys Ile Cys Gly Arg Ala Phe Ser Thr Lys Gly Asn 
        595                 600                 605             


Leu Lys Thr His Leu Gly Val His Arg Thr Asn Thr Ser Ile Lys Thr 
    610                 615                 620                 


Gln His Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val Met 
625                 630                 635                 640 


Leu Gln Gln His Ile Arg Met His Met Gly Gly Gln Ile Pro Asn Thr 
                645                 650                 655     


Pro Leu Pro Glu Asn Pro Cys Asp Phe Thr Gly Ser Glu Pro Met Thr 
            660                 665                 670         


Val Gly Glu Asn Gly Ser Thr Gly Ala Ile Cys His Asp Asp Val Ile 
        675                 680                 685             


Glu Ser Ile Asp Val Glu Glu Val Ser Ser Gln Glu Ala Pro Ser Ser 
    690                 695                 700                 


Ser Ser Lys Val Pro Thr Pro Leu Pro Ser Ile His Ser Ala Ser Pro 
705                 710                 715                 720 


Thr Leu Gly Phe Ala Met Met Ala Ser Leu Asp Ala Pro Gly Lys Val 
                725                 730                 735     


Gly Pro Ala Pro Phe Asn Leu Gln Arg Gln Gly Ser Arg Glu Asn Gly 
            740                 745                 750         


Ser Val Glu Ser Asp Gly Leu Thr Asn Asp Ser Ser Ser Leu Met Gly 
        755                 760                 765             


Asp Gln Glu Tyr Gln Ser Arg Ser Pro Asp Ile Leu Glu Thr Thr Ser 
    770                 775                 780                 


Phe Gln Ala Leu Ser Pro Ala Asn Ser Gln Ala Glu Ser Ile Lys Ser 
785                 790                 795                 800 


Lys Ser Pro Asp Ala Gly Ser Lys Ala Glu Ser Ser Glu Asn Ser Arg 
                805                 810                 815     


Thr Glu Met Glu Gly Arg Ser Ser Leu Pro Ser Thr Phe Ile Arg Ala 
            820                 825                 830         


Pro Pro Thr Tyr Val Lys Val Glu Val Pro Gly Thr Phe Val Gly Pro 
        835                 840                 845             


Ser Thr Leu Ser Pro Gly Met Thr Pro Leu Leu Ala Ala Gln Pro Arg 
    850                 855                 860                 


Arg Gln Ala Lys Gln His Gly Cys Thr Arg Cys Gly Lys Asn Phe Ser 
865                 870                 875                 880 


Ser Ala Ser Ala Leu Gln Ile His Glu Arg Thr His Thr Gly Glu Lys 
                885                 890                 895     


Pro Phe Val Cys Asn Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn 
            900                 905                 910         


Leu Lys Val His Tyr Met Thr His Gly Ala Asn Asn Asn Ser Ala Arg 
        915                 920                 925             


Arg Gly Arg Lys Leu Ala Ile Glu Asn Thr Met Ala Leu Leu Gly Thr 
    930                 935                 940                 


Asp Gly Lys Arg Val Ser Glu Ile Phe Pro Lys Glu Ile Leu Ala Pro 
945                 950                 955                 960 


Ser Val Asn Val Asp Pro Val Val Trp Asn Gln Tyr Thr Ser Met Leu 
                965                 970                 975     


Asn Gly Gly Leu Ala Val Lys Thr Asn Glu Ile Ser Val Ile Gln Ser 
            980                 985                 990         


Gly Gly Val Pro Thr Leu Pro Val  Ser Leu Gly Ala Thr  Ser Val Val 
        995                 1000                 1005             


Asn Asn  Ala Thr Val Ser Lys  Met Asp Gly Ser Gln  Ser Gly Ile 
    1010                 1015                 1020             


Ser Ala  Asp Val Glu Lys Pro  Ser Ala Thr Asp Gly  Val Pro Lys 
    1025                 1030                 1035             


His Gln  Phe Pro His Phe Leu  Glu Glu Asn Lys Ile  Ala Val Ser 
    1040                 1045                 1050             


<210>  49
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, ELF1

<400>  49

Met Ala Ala Val Val Gln Gln Asn Asp Leu Val Phe Glu Phe Ala Ser 
1               5                   10                  15      


Asn Val Met Glu Asp Glu Arg Gln Leu Gly Asp Pro Ala Ile Phe Pro 
            20                  25                  30          


Ala Val Ile Val Glu His Val Pro Gly Ala Asp Ile Leu Asn Ser Tyr 
        35                  40                  45              


Ala Gly Leu Ala Cys Val Glu Glu Pro Asn Asp Met Ile Thr Glu Ser 
    50                  55                  60                  


Ser Leu Asp Val Ala Glu Glu Glu Ile Ile Asp Asp Asp Asp Asp Asp 
65                  70                  75                  80  


Ile Thr Leu Thr Val Glu Ala Ser Cys His Asp Gly Asp Glu Thr Ile 
                85                  90                  95      


Glu Thr Ile Glu Ala Ala Glu Ala Leu Leu Asn Met Asp Ser Pro Gly 
            100                 105                 110         


Pro Met Leu Asp Glu Lys Arg Ile Asn Asn Asn Ile Phe Ser Ser Pro 
        115                 120                 125             


Glu Asp Asp Met Val Val Ala Pro Val Thr His Val Ser Val Thr Leu 
    130                 135                 140                 


Asp Gly Ile Pro Glu Val Met Glu Thr Gln Gln Val Gln Glu Lys Tyr 
145                 150                 155                 160 


Ala Asp Ser Pro Gly Ala Ser Ser Pro Glu Gln Pro Lys Arg Lys Lys 
                165                 170                 175     


Gly Arg Lys Thr Lys Pro Pro Arg Pro Asp Ser Pro Ala Thr Thr Pro 
            180                 185                 190         


Asn Ile Ser Val Lys Lys Lys Asn Lys Asp Gly Lys Gly Asn Thr Ile 
        195                 200                 205             


Tyr Leu Trp Glu Phe Leu Leu Ala Leu Leu Gln Asp Lys Ala Thr Cys 
    210                 215                 220                 


Pro Lys Tyr Ile Lys Trp Thr Gln Arg Glu Lys Gly Ile Phe Lys Leu 
225                 230                 235                 240 


Val Asp Ser Lys Ala Val Ser Arg Leu Trp Gly Lys His Lys Asn Lys 
                245                 250                 255     


Pro Asp Met Asn Tyr Glu Thr Met Gly Arg Ala Leu Arg Tyr Tyr Tyr 
            260                 265                 270         


Gln Arg Gly Ile Leu Ala Lys Val Glu Gly Gln Arg Leu Val Tyr Gln 
        275                 280                 285             


Phe Lys Glu Met Pro Lys Asp Leu Ile Tyr Ile Asn Asp Glu Asp Pro 
    290                 295                 300                 


Ser Ser Ser Ile Glu Ser Ser Asp Pro Ser Leu Ser Ser Ser Ala Thr 
305                 310                 315                 320 


Ser Asn Arg Asn Gln Thr Ser Arg Ser Arg Val Ser Ser Ser Pro Gly 
                325                 330                 335     


Val Lys Gly Gly Ala Thr Thr Val Leu Lys Pro Gly Asn Ser Lys Ala 
            340                 345                 350         


Ala Lys Pro Lys Asp Pro Val Glu Val Ala Gln Pro Ser Glu Val Leu 
        355                 360                 365             


Arg Thr Val Gln Pro Thr Gln Ser Pro Tyr Pro Thr Gln Leu Phe Arg 
    370                 375                 380                 


Thr Val His Val Val Gln Pro Val Gln Ala Val Pro Glu Gly Glu Ala 
385                 390                 395                 400 


Ala Arg Thr Ser Thr Met Gln Asp Glu Thr Leu Asn Ser Ser Val Gln 
                405                 410                 415     


Ser Ile Arg Thr Ile Gln Ala Pro Thr Gln Val Pro Val Val Val Ser 
            420                 425                 430         


Pro Arg Asn Gln Gln Leu His Thr Val Thr Leu Gln Thr Val Pro Leu 
        435                 440                 445             


Thr Thr Val Ile Ala Ser Thr Asp Pro Ser Ala Gly Thr Gly Ser Gln 
    450                 455                 460                 


Lys Phe Ile Leu Gln Ala Ile Pro Ser Ser Gln Pro Met Thr Val Leu 
465                 470                 475                 480 


Lys Glu Asn Val Met Leu Gln Ser Gln Lys Ala Gly Ser Pro Pro Ser 
                485                 490                 495     


Ile Val Leu Gly Pro Ala Gln Val Gln Gln Val Leu Thr Ser Asn Val 
            500                 505                 510         


Gln Thr Ile Cys Asn Gly Thr Val Ser Val Ala Ser Ser Pro Ser Phe 
        515                 520                 525             


Ser Ala Thr Ala Pro Val Val Thr Phe Ser Pro Arg Ser Ser Gln Leu 
    530                 535                 540                 


Val Ala His Pro Pro Gly Thr Val Ile Thr Ser Val Ile Lys Thr Gln 
545                 550                 555                 560 


Glu Thr Lys Thr Leu Thr Gln Glu Val Glu Lys Lys Glu Ser Glu Asp 
                565                 570                 575     


His Leu Lys Glu Asn Thr Glu Lys Thr Glu Gln Gln Pro Gln Pro Tyr 
            580                 585                 590         


Val Met Val Val Ser Ser Ser Asn Gly Phe Thr Ser Gln Val Ala Met 
        595                 600                 605             


Lys Gln Asn Glu Leu Leu Glu Pro Asn Ser Phe 
    610                 615                 


<210>  50
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, SOX9

<400>  50

Met Asn Leu Leu Asp Pro Phe Met Lys Met Thr Asp Glu Gln Glu Lys 
1               5                   10                  15      


Gly Leu Ser Gly Ala Pro Ser Pro Thr Met Ser Glu Asp Ser Ala Gly 
            20                  25                  30          


Ser Pro Cys Pro Ser Gly Ser Gly Ser Asp Thr Glu Asn Thr Arg Pro 
        35                  40                  45              


Gln Glu Asn Thr Phe Pro Lys Gly Glu Pro Asp Leu Lys Lys Glu Ser 
    50                  55                  60                  


Glu Glu Asp Lys Phe Pro Val Cys Ile Arg Glu Ala Val Ser Gln Val 
65                  70                  75                  80  


Leu Lys Gly Tyr Asp Trp Thr Leu Val Pro Met Pro Val Arg Val Asn 
                85                  90                  95      


Gly Ser Ser Lys Asn Lys Pro His Val Lys Arg Pro Met Asn Ala Phe 
            100                 105                 110         


Met Val Trp Ala Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro 
        115                 120                 125             


His Leu His Asn Ala Glu Leu Ser Lys Thr Leu Gly Lys Leu Trp Arg 
    130                 135                 140                 


Leu Leu Asn Glu Ser Glu Lys Arg Pro Phe Val Glu Glu Ala Glu Arg 
145                 150                 155                 160 


Leu Arg Val Gln His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro 
                165                 170                 175     


Arg Arg Arg Lys Ser Val Lys Asn Gly Gln Ala Glu Ala Glu Glu Ala 
            180                 185                 190         


Thr Glu Gln Thr His Ile Ser Pro Asn Ala Ile Phe Lys Ala Leu Gln 
        195                 200                 205             


Ala Asp Ser Pro His Ser Ser Ser Gly Met Ser Glu Val His Ser Pro 
    210                 215                 220                 


Gly Glu His Ser Gly Gln Ser Gln Gly Pro Pro Thr Pro Pro Thr Thr 
225                 230                 235                 240 


Pro Lys Thr Asp Val Gln Pro Gly Lys Ala Asp Leu Lys Arg Glu Gly 
                245                 250                 255     


Arg Pro Leu Pro Glu Gly Gly Arg Gln Pro Pro Ile Asp Phe Arg Asp 
            260                 265                 270         


Val Asp Ile Gly Glu Leu Ser Ser Asp Val Ile Ser Asn Ile Glu Thr 
        275                 280                 285             


Phe Asp Val Asn Glu Phe Asp Gln Tyr Leu Pro Pro Asn Gly His Pro 
    290                 295                 300                 


Gly Val Pro Ala Thr His Gly Gln Val Thr Tyr Thr Gly Ser Tyr Gly 
305                 310                 315                 320 


Ile Ser Ser Thr Ala Ala Thr Pro Ala Ser Ala Gly His Val Trp Met 
                325                 330                 335     


Ser Lys Gln Gln Ala Pro Pro Pro Pro Pro Gln Gln Pro Pro Gln Ala 
            340                 345                 350         


Pro Pro Ala Pro Gln Ala Pro Pro Gln Pro Gln Ala Ala Pro Pro Gln 
        355                 360                 365             


Gln Pro Ala Ala Pro Pro Gln Gln Pro Gln Ala His Thr Leu Thr Thr 
    370                 375                 380                 


Leu Ser Ser Glu Pro Gly Gln Ser Gln Arg Thr His Ile Lys Thr Glu 
385                 390                 395                 400 


Gln Leu Ser Pro Ser His Tyr Ser Glu Gln Gln Gln His Ser Pro Gln 
                405                 410                 415     


Gln Ile Ala Tyr Ser Pro Phe Asn Leu Pro His Tyr Ser Pro Ser Tyr 
            420                 425                 430         


Pro Pro Ile Thr Arg Ser Gln Tyr Asp Tyr Thr Asp His Gln Asn Ser 
        435                 440                 445             


Ser Ser Tyr Tyr Ser His Ala Ala Gly Gln Gly Thr Gly Leu Tyr Ser 
    450                 455                 460                 


Thr Phe Thr Tyr Met Asn Pro Ala Gln Arg Pro Met Tyr Thr Pro Ile 
465                 470                 475                 480 


Ala Asp Thr Ser Gly Val Pro Ser Ile Pro Gln Thr His Ser Pro Gln 
                485                 490                 495     


His Trp Glu Gln Pro Val Tyr Thr Gln Leu Thr Arg Pro 
            500                 505                 


<210>  51
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       SOX12

<400>  51

Met Val Gln Gln Arg Gly Ala Arg Ala Lys Arg Asp Gly Gly Pro Pro 
1               5                   10                  15      


Pro Pro Gly Pro Gly Pro Ala Glu Glu Gly Ala Arg Glu Pro Gly Trp 
            20                  25                  30          


Cys Lys Thr Pro Ser Gly His Ile Lys Arg Pro Met Asn Ala Phe Met 
        35                  40                  45              


Val Trp Ser Gln His Glu Arg Arg Lys Ile Met Asp Gln Trp Pro Asp 
    50                  55                  60                  


Met His Asn Ala Glu Ile Ser Lys Arg Leu Gly Arg Arg Trp Gln Leu 
65                  70                  75                  80  


Leu Gln Asp Ser Glu Lys Ile Pro Phe Val Arg Glu Ala Glu Arg Leu 
                85                  90                  95      


Arg Leu Lys His Met Ala Asp Tyr Pro Asp Tyr Lys Tyr Arg Pro Arg 
            100                 105                 110         


Lys Lys Ser Lys Gly Ala Pro Ala Lys Ala Arg Pro Arg Pro Pro Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Arg Leu Lys Pro Gly Pro Gln Leu Pro Gly 
    130                 135                 140                 


Arg Gly Gly Arg Arg Ala Ala Gly Gly Pro Leu Gly Gly Gly Ala Ala 
145                 150                 155                 160 


Ala Pro Glu Asp Asp Asp Glu Asp Asp Asp Glu Glu Leu Leu Glu Val 
                165                 170                 175     


Arg Leu Val Glu Thr Pro Gly Arg Glu Leu Trp Arg Met Val Pro Ala 
            180                 185                 190         


Gly Arg Ala Ala Arg Gly Gln Ala Glu Arg Ala Gln Gly Pro Ser Gly 
        195                 200                 205             


Glu Gly Ala Ala Ala Ala Ala Ala Ala Ser Pro Thr Pro Ser Glu Asp 
    210                 215                 220                 


Glu Glu Pro Glu Glu Glu Glu Glu Glu Ala Ala Ala Ala Glu Glu Gly 
225                 230                 235                 240 


Glu Glu Glu Thr Val Ala Ser Gly Glu Glu Ser Leu Gly Phe Leu Ser 
                245                 250                 255     


Arg Leu Pro Pro Gly Pro Ala Gly Leu Asp Cys Ser Ala Leu Asp Arg 
            260                 265                 270         


Asp Pro Asp Leu Gln Pro Pro Ser Gly Thr Ser His Phe Glu Phe Pro 
        275                 280                 285             


Asp Tyr Cys Thr Pro Glu Val Thr Glu Met Ile Ala Gly Asp Trp Arg 
    290                 295                 300                 


Pro Ser Ser Ile Ala Asp Leu Val Phe Thr Tyr 
305                 310                 315 


<210>  52
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       SOX18

<400>  52

Met Gln Arg Ser Pro Pro Gly Tyr Gly Ala Gln Asp Asp Pro Pro Ala 
1               5                   10                  15      


Arg Arg Asp Cys Ala Trp Ala Pro Gly His Gly Ala Ala Ala Asp Thr 
            20                  25                  30          


Arg Gly Leu Ala Ala Gly Pro Ala Ala Leu Ala Ala Pro Ala Ala Pro 
        35                  40                  45              


Ala Ser Pro Pro Ser Pro Gln Arg Ser Pro Pro Arg Ser Pro Glu Pro 
    50                  55                  60                  


Gly Arg Tyr Gly Leu Ser Pro Ala Gly Arg Gly Glu Arg Gln Ala Ala 
65                  70                  75                  80  


Asp Glu Ser Arg Ile Arg Arg Pro Met Asn Ala Phe Met Val Trp Ala 
                85                  90                  95      


Lys Asp Glu Arg Lys Arg Leu Ala Gln Gln Asn Pro Asp Leu His Asn 
            100                 105                 110         


Ala Val Leu Ser Lys Met Leu Gly Lys Ala Trp Lys Glu Leu Asn Ala 
        115                 120                 125             


Ala Glu Lys Arg Pro Phe Val Glu Glu Ala Glu Arg Leu Arg Val Gln 
    130                 135                 140                 


His Leu Arg Asp His Pro Asn Tyr Lys Tyr Arg Pro Arg Arg Lys Lys 
145                 150                 155                 160 


Gln Ala Arg Lys Ala Arg Arg Leu Glu Pro Gly Leu Leu Leu Pro Gly 
                165                 170                 175     


Leu Ala Pro Pro Gln Pro Pro Pro Glu Pro Phe Pro Ala Ala Ser Gly 
            180                 185                 190         


Ser Ala Arg Ala Phe Arg Glu Leu Pro Pro Leu Gly Ala Glu Phe Asp 
        195                 200                 205             


Gly Leu Gly Leu Pro Thr Pro Glu Arg Ser Pro Leu Asp Gly Leu Glu 
    210                 215                 220                 


Pro Gly Glu Ala Ala Phe Phe Pro Pro Pro Ala Ala Pro Glu Asp Cys 
225                 230                 235                 240 


Ala Leu Arg Pro Phe Arg Ala Pro Tyr Ala Pro Thr Glu Leu Ser Arg 
                245                 250                 255     


Asp Pro Gly Gly Cys Tyr Gly Ala Pro Leu Ala Glu Ala Leu Arg Thr 
            260                 265                 270         


Ala Pro Pro Ala Ala Pro Leu Ala Gly Leu Tyr Tyr Gly Thr Leu Gly 
        275                 280                 285             


Thr Pro Gly Pro Tyr Pro Gly Pro Leu Ser Pro Pro Pro Glu Ala Pro 
    290                 295                 300                 


Pro Leu Glu Ser Ala Glu Pro Leu Gly Pro Ala Ala Asp Leu Trp Ala 
305                 310                 315                 320 


Asp Val Asp Leu Thr Glu Phe Asp Gln Tyr Leu Asn Cys Ser Arg Thr 
                325                 330                 335     


Arg Pro Asp Ala Pro Gly Leu Pro Tyr His Val Ala Leu Ala Lys Leu 
            340                 345                 350         


Gly Pro Arg Ala Met Ser Cys Pro Glu Glu Ser Ser Leu Ile Ser Ala 
        355                 360                 365             


Leu Ser Asp Ala Ser Ser Ala Val Tyr Tyr Ser Ala Cys Ile Ser Gly 
    370                 375                 380                 


<210>  53
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, ETS1

<400>  53

Met Lys Ala Ala Val Asp Leu Lys Pro Thr Leu Thr Ile Ile Lys Thr 
1               5                   10                  15      


Glu Lys Val Asp Leu Glu Leu Phe Pro Ser Pro Asp Met Glu Cys Ala 
            20                  25                  30          


Asp Val Pro Leu Leu Thr Pro Ser Ser Lys Glu Met Met Ser Gln Ala 
        35                  40                  45              


Leu Lys Ala Thr Phe Ser Gly Phe Thr Lys Glu Gln Gln Arg Leu Gly 
    50                  55                  60                  


Ile Pro Lys Asp Pro Arg Gln Trp Thr Glu Thr His Val Arg Asp Trp 
65                  70                  75                  80  


Val Met Trp Ala Val Asn Glu Phe Ser Leu Lys Gly Val Asp Phe Gln 
                85                  90                  95      


Lys Phe Cys Met Asn Gly Ala Ala Leu Cys Ala Leu Gly Lys Asp Cys 
            100                 105                 110         


Phe Leu Glu Leu Ala Pro Asp Phe Val Gly Asp Ile Leu Trp Glu His 
        115                 120                 125             


Leu Glu Ile Leu Gln Lys Glu Asp Val Lys Pro Tyr Gln Val Asn Gly 
    130                 135                 140                 


Val Asn Pro Ala Tyr Pro Glu Ser Arg Tyr Thr Ser Asp Tyr Phe Ile 
145                 150                 155                 160 


Ser Tyr Gly Ile Glu His Ala Gln Cys Val Pro Pro Ser Glu Phe Ser 
                165                 170                 175     


Glu Pro Ser Phe Ile Thr Glu Ser Tyr Gln Thr Leu His Pro Ile Ser 
            180                 185                 190         


Ser Glu Glu Leu Leu Ser Leu Lys Tyr Glu Asn Asp Tyr Pro Ser Val 
        195                 200                 205             


Ile Leu Arg Asp Pro Leu Gln Thr Asp Thr Leu Gln Asn Asp Tyr Phe 
    210                 215                 220                 


Ala Ile Lys Gln Glu Val Val Thr Pro Asp Asn Met Cys Met Gly Arg 
225                 230                 235                 240 


Thr Ser Arg Gly Lys Leu Gly Gly Gln Asp Ser Phe Glu Ser Ile Glu 
                245                 250                 255     


Ser Tyr Asp Ser Cys Asp Arg Leu Thr Gln Ser Trp Ser Ser Gln Ser 
            260                 265                 270         


Ser Phe Asn Ser Leu Gln Arg Val Pro Ser Tyr Asp Ser Phe Asp Ser 
        275                 280                 285             


Glu Asp Tyr Pro Ala Ala Leu Pro Asn His Lys Pro Lys Gly Thr Phe 
    290                 295                 300                 


Lys Asp Tyr Val Arg Asp Arg Ala Asp Leu Asn Lys Asp Lys Pro Val 
305                 310                 315                 320 


Ile Pro Ala Ala Ala Leu Ala Gly Tyr Thr Gly Ser Gly Pro Ile Gln 
                325                 330                 335     


Leu Trp Gln Phe Leu Leu Glu Leu Leu Thr Asp Lys Ser Cys Gln Ser 
            340                 345                 350         


Phe Ile Ser Trp Thr Gly Asp Gly Trp Glu Phe Lys Leu Ser Asp Pro 
        355                 360                 365             


Asp Glu Val Ala Arg Arg Trp Gly Lys Arg Lys Asn Lys Pro Lys Met 
    370                 375                 380                 


Asn Tyr Glu Lys Leu Ser Arg Gly Leu Arg Tyr Tyr Tyr Asp Lys Asn 
385                 390                 395                 400 


Ile Ile His Lys Thr Ala Gly Lys Arg Tyr Val Tyr Arg Phe Val Cys 
                405                 410                 415     


Asp Leu Gln Ser Leu Leu Gly Tyr Thr Pro Glu Glu Leu His Ala Met 
            420                 425                 430         


Leu Asp Val Lys Pro Asp Ala Asp Glu 
        435                 440     


<210>  54
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, PAX3

<400>  54

Met Thr Thr Leu Ala Gly Ala Val Pro Arg Met Met Arg Pro Gly Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Ser Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Lys Gln Val Thr Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Lys Leu Leu Lys Asp Ala Val Cys Asp 
    130                 135                 140                 


Arg Asn Thr Val Pro Ser Val Ser Ser Ile Ser Arg Ile Leu Arg Ser 
145                 150                 155                 160 


Lys Phe Gly Lys Gly Glu Glu Glu Glu Ala Asp Leu Glu Arg Lys Glu 
                165                 170                 175     


Ala Glu Glu Ser Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Ser Glu Arg Gly Lys Ala Leu Val Ser Gly Val Ser Ser His 
        195                 200                 205     


<210>  55
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, PAX8

<400>  55

Met Pro His Asn Ser Ile Arg Ser Gly His Gly Gly Leu Asn Gln Leu 
1               5                   10                  15      


Gly Gly Ala Phe Val Asn Gly Arg Pro Leu Pro Glu Val Val Arg Gln 
            20                  25                  30          


Arg Ile Val Asp Leu Ala His Gln Gly Val Arg Pro Cys Asp Ile Ser 
        35                  40                  45              


Arg Gln Leu Arg Val Ser His Gly Cys Val Ser Lys Ile Leu Gly Arg 
    50                  55                  60                  


Tyr Tyr Glu Thr Gly Ser Ile Arg Pro Gly Val Ile Gly Gly Ser Lys 
65                  70                  75                  80  


Pro Lys Val Ala Thr Pro Lys Val Val Glu Lys Ile Gly Asp Tyr Lys 
                85                  90                  95      


Arg Gln Asn Pro Thr Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu 
            100                 105                 110         


Ala Glu Gly Val Cys Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile 
        115                 120                 125             


Asn Arg Ile Ile Arg Thr Lys Val Gln Gln Pro Phe Asn Leu Pro Met 
    130                 135                 140                 


Asp Ser Cys Val Ala Thr Lys Ser Leu Ser Pro Gly His Thr Leu Ile 
145                 150                 155                 160 


Pro Ser Ser Ala Val Thr Pro Pro Glu Ser Pro Gln Ser Asp Ser Leu 
                165                 170                 175     


Gly Ser Thr Tyr Ser Ile Asn Gly Leu Leu Gly Ile Ala Gln Pro Gly 
            180                 185                 190         


Ser Asp Lys Arg Lys Met Asp Asp Ser Asp Gln Asp Ser Cys Arg Leu 
        195                 200                 205             


Ser Ile Asp Ser Gln Ser Ser Ser Ser Gly Pro Arg Lys His Leu Arg 
    210                 215                 220                 


Thr Asp Ala Phe Ser Gln His His Leu Glu Pro Leu Glu Cys Pro Phe 
225                 230                 235                 240 


Glu Arg Gln His Tyr Pro Glu Ala Tyr Ala Ser Pro Ser His Thr Lys 
                245                 250                 255     


Gly Glu Gln Gly Leu Tyr Pro Leu Pro Leu Leu Asn Ser Thr Leu Asp 
            260                 265                 270         


Asp Gly Lys Ala Thr Leu Thr Pro Ser Asn Thr Pro Leu Gly Arg Asn 
        275                 280                 285             


Leu Ser Thr His Gln Thr Tyr Pro Val Val Ala Asp Pro His Ser Pro 
    290                 295                 300                 


Phe Ala Ile Lys Gln Glu Thr Pro Glu Val Ser Ser Ser Ser Ser Thr 
305                 310                 315                 320 


Pro Ser Ser Leu Ser Ser Ser Ala Phe Leu Asp Leu Gln Gln Val Gly 
                325                 330                 335     


Ser Gly Val Pro Pro Phe Asn Ala Phe Pro His Ala Ala Ser Val Tyr 
            340                 345                 350         


Gly Gln Phe Thr Gly Gln Ala Leu Leu Ser Gly Arg Glu Met Val Gly 
        355                 360                 365             


Pro Thr Leu Pro Gly Tyr Pro Pro His Ile Pro Thr Ser Gly Gln Gly 
    370                 375                 380                 


Ser Tyr Ala Ser Ser Ala Ile Ala Gly Met Val Ala Gly Ser Glu Tyr 
385                 390                 395                 400 


Ser Gly Asn Ala Tyr Gly His Thr Pro Tyr Ser Ser Tyr Ser Glu Ala 
                405                 410                 415     


Trp Arg Phe Pro Asn Ser Ser Leu Leu Ser Ser Pro Tyr Tyr Tyr Ser 
            420                 425                 430         


Ser Thr Ser Arg Pro Ser Ala Pro Pro Thr Thr Ala Thr Ala Phe Asp 
        435                 440                 445             


His Leu 
    450 


<210>  56
<211>  1106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, GLI1

<400>  56

Met Phe Asn Ser Met Thr Pro Pro Pro Ile Ser Ser Tyr Gly Glu Pro 
1               5                   10                  15      


Cys Cys Leu Arg Pro Leu Pro Ser Gln Gly Ala Pro Ser Val Gly Thr 
            20                  25                  30          


Glu Gly Leu Ser Gly Pro Pro Phe Cys His Gln Ala Asn Leu Met Ser 
        35                  40                  45              


Gly Pro His Ser Tyr Gly Pro Ala Arg Glu Thr Asn Ser Cys Thr Glu 
    50                  55                  60                  


Gly Pro Leu Phe Ser Ser Pro Arg Ser Ala Val Lys Leu Thr Lys Lys 
65                  70                  75                  80  


Arg Ala Leu Ser Ile Ser Pro Leu Ser Asp Ala Ser Leu Asp Leu Gln 
                85                  90                  95      


Thr Val Ile Arg Thr Ser Pro Ser Ser Leu Val Ala Phe Ile Asn Ser 
            100                 105                 110         


Arg Cys Thr Ser Pro Gly Gly Ser Tyr Gly His Leu Ser Ile Gly Thr 
        115                 120                 125             


Met Ser Pro Ser Leu Gly Phe Pro Ala Gln Met Asn His Gln Lys Gly 
    130                 135                 140                 


Pro Ser Pro Ser Phe Gly Val Gln Pro Cys Gly Pro His Asp Ser Ala 
145                 150                 155                 160 


Arg Gly Gly Met Ile Pro His Pro Gln Ser Arg Gly Pro Phe Pro Thr 
                165                 170                 175     


Cys Gln Leu Lys Ser Glu Leu Asp Met Leu Val Gly Lys Cys Arg Glu 
            180                 185                 190         


Glu Pro Leu Glu Gly Asp Met Ser Ser Pro Asn Ser Thr Gly Ile Gln 
        195                 200                 205             


Asp Pro Leu Leu Gly Met Leu Asp Gly Arg Glu Asp Leu Glu Arg Glu 
    210                 215                 220                 


Glu Lys Arg Glu Pro Glu Ser Val Tyr Glu Thr Asp Cys Arg Trp Asp 
225                 230                 235                 240 


Gly Cys Ser Gln Glu Phe Asp Ser Gln Glu Gln Leu Val His His Ile 
                245                 250                 255     


Asn Ser Glu His Ile His Gly Glu Arg Lys Glu Phe Val Cys His Trp 
            260                 265                 270         


Gly Gly Cys Ser Arg Glu Leu Arg Pro Phe Lys Ala Gln Tyr Met Leu 
        275                 280                 285             


Val Val His Met Arg Arg His Thr Gly Glu Lys Pro His Lys Cys Thr 
    290                 295                 300                 


Phe Glu Gly Cys Arg Lys Ser Tyr Ser Arg Leu Glu Asn Leu Lys Thr 
305                 310                 315                 320 


His Leu Arg Ser His Thr Gly Glu Lys Pro Tyr Met Cys Glu His Glu 
                325                 330                 335     


Gly Cys Ser Lys Ala Phe Ser Asn Ala Ser Asp Arg Ala Lys His Gln 
            340                 345                 350         


Asn Arg Thr His Ser Asn Glu Lys Pro Tyr Val Cys Lys Leu Pro Gly 
        355                 360                 365             


Cys Thr Lys Arg Tyr Thr Asp Pro Ser Ser Leu Arg Lys His Val Lys 
    370                 375                 380                 


Thr Val His Gly Pro Asp Ala His Val Thr Lys Arg His Arg Gly Asp 
385                 390                 395                 400 


Gly Pro Leu Pro Arg Ala Pro Ser Ile Ser Thr Val Glu Pro Lys Arg 
                405                 410                 415     


Glu Arg Glu Gly Gly Pro Ile Arg Glu Glu Ser Arg Leu Thr Val Pro 
            420                 425                 430         


Glu Gly Ala Met Lys Pro Gln Pro Ser Pro Gly Ala Gln Ser Ser Cys 
        435                 440                 445             


Ser Ser Asp His Ser Pro Ala Gly Ser Ala Ala Asn Thr Asp Ser Gly 
    450                 455                 460                 


Val Glu Met Thr Gly Asn Ala Gly Gly Ser Thr Glu Asp Leu Ser Ser 
465                 470                 475                 480 


Leu Asp Glu Gly Pro Cys Ile Ala Gly Thr Gly Leu Ser Thr Leu Arg 
                485                 490                 495     


Arg Leu Glu Asn Leu Arg Leu Asp Gln Leu His Gln Leu Arg Pro Ile 
            500                 505                 510         


Gly Thr Arg Gly Leu Lys Leu Pro Ser Leu Ser His Thr Gly Thr Thr 
        515                 520                 525             


Val Ser Arg Arg Val Gly Pro Pro Val Ser Leu Glu Arg Arg Ser Ser 
    530                 535                 540                 


Ser Ser Ser Ser Ile Ser Ser Ala Tyr Thr Val Ser Arg Arg Ser Ser 
545                 550                 555                 560 


Leu Ala Ser Pro Phe Pro Pro Gly Ser Pro Pro Glu Asn Gly Ala Ser 
                565                 570                 575     


Ser Leu Pro Gly Leu Met Pro Ala Gln His Tyr Leu Leu Arg Ala Arg 
            580                 585                 590         


Tyr Ala Ser Ala Arg Gly Gly Gly Thr Ser Pro Thr Ala Ala Ser Ser 
        595                 600                 605             


Leu Asp Arg Ile Gly Gly Leu Pro Met Pro Pro Trp Arg Ser Arg Ala 
    610                 615                 620                 


Glu Tyr Pro Gly Tyr Asn Pro Asn Ala Gly Val Thr Arg Arg Ala Ser 
625                 630                 635                 640 


Asp Pro Ala Gln Ala Ala Asp Arg Pro Ala Pro Ala Arg Val Gln Arg 
                645                 650                 655     


Phe Lys Ser Leu Gly Cys Val His Thr Pro Pro Thr Val Ala Gly Gly 
            660                 665                 670         


Gly Gln Asn Phe Asp Pro Tyr Leu Pro Thr Ser Val Tyr Ser Pro Gln 
        675                 680                 685             


Pro Pro Ser Ile Thr Glu Asn Ala Ala Met Asp Ala Arg Gly Leu Gln 
    690                 695                 700                 


Glu Glu Pro Glu Val Gly Thr Ser Met Val Gly Ser Gly Leu Asn Pro 
705                 710                 715                 720 


Tyr Met Asp Phe Pro Pro Thr Asp Thr Leu Gly Tyr Gly Gly Pro Glu 
                725                 730                 735     


Gly Ala Ala Ala Glu Pro Tyr Gly Ala Arg Gly Pro Gly Ser Leu Pro 
            740                 745                 750         


Leu Gly Pro Gly Pro Pro Thr Asn Tyr Gly Pro Asn Pro Cys Pro Gln 
        755                 760                 765             


Gln Ala Ser Tyr Pro Asp Pro Thr Gln Glu Thr Trp Gly Glu Phe Pro 
    770                 775                 780                 


Ser His Ser Gly Leu Tyr Pro Gly Pro Lys Ala Leu Gly Gly Thr Tyr 
785                 790                 795                 800 


Ser Gln Cys Pro Arg Leu Glu His Tyr Gly Gln Val Gln Val Lys Pro 
                805                 810                 815     


Glu Gln Gly Cys Pro Val Gly Ser Asp Ser Thr Gly Leu Ala Pro Cys 
            820                 825                 830         


Leu Asn Ala His Pro Ser Glu Gly Pro Pro His Pro Gln Pro Leu Phe 
        835                 840                 845             


Ser His Tyr Pro Gln Pro Ser Pro Pro Gln Tyr Leu Gln Ser Gly Pro 
    850                 855                 860                 


Tyr Thr Gln Pro Pro Pro Asp Tyr Leu Pro Ser Glu Pro Arg Pro Cys 
865                 870                 875                 880 


Leu Asp Phe Asp Ser Pro Thr His Ser Thr Gly Gln Leu Lys Ala Gln 
                885                 890                 895     


Leu Val Cys Asn Tyr Val Gln Ser Gln Gln Glu Leu Leu Trp Glu Gly 
            900                 905                 910         


Gly Gly Arg Glu Asp Ala Pro Ala Gln Glu Pro Ser Tyr Gln Ser Pro 
        915                 920                 925             


Lys Phe Leu Gly Gly Ser Gln Val Ser Pro Ser Arg Ala Lys Ala Pro 
    930                 935                 940                 


Val Asn Thr Tyr Gly Pro Gly Phe Gly Pro Asn Leu Pro Asn His Lys 
945                 950                 955                 960 


Ser Gly Ser Tyr Pro Thr Pro Ser Pro Cys His Glu Asn Phe Val Val 
                965                 970                 975     


Gly Ala Asn Arg Ala Ser His Arg Ala Ala Ala Pro Pro Arg Leu Leu 
            980                 985                 990         


Pro Pro Leu Pro Thr Cys Tyr Gly  Pro Leu Lys Val Gly  Gly Thr Asn 
        995                 1000                 1005             


Pro Ser  Cys Gly His Pro Glu  Val Gly Arg Leu Gly  Gly Gly Pro 
    1010                 1015                 1020             


Ala Leu  Tyr Pro Pro Pro Glu  Gly Gln Val Cys Asn  Pro Leu Asp 
    1025                 1030                 1035             


Ser Leu  Asp Leu Asp Asn Thr  Gln Leu Asp Phe Val  Ala Ile Leu 
    1040                 1045                 1050             


Asp Glu  Pro Gln Gly Leu Ser  Pro Pro Pro Ser His  Asp Gln Arg 
    1055                 1060                 1065             


Gly Ser  Ser Gly His Thr Pro  Pro Pro Ser Gly Pro  Pro Asn Met 
    1070                 1075                 1080             


Ala Val  Gly Asn Met Ser Val  Leu Leu Arg Ser Leu  Pro Gly Glu 
    1085                 1090                 1095             


Thr Glu  Phe Leu Asn Ser Ser  Ala 
    1100                 1105     


<210>  57
<211>  1586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, GLI2

<400>  57

Met Glu Thr Ser Ala Ser Ala Thr Ala Ser Glu Lys Gln Glu Ala Lys 
1               5                   10                  15      


Ser Gly Ile Leu Glu Ala Ala Gly Phe Pro Asp Pro Gly Lys Lys Ala 
            20                  25                  30          


Ser Pro Leu Val Val Ala Ala Ala Ala Ala Ala Ala Val Ala Ala Gln 
        35                  40                  45              


Gly Val Pro Gln His Leu Leu Pro Pro Phe His Ala Pro Leu Pro Ile 
    50                  55                  60                  


Asp Met Arg His Gln Glu Gly Arg Tyr His Tyr Glu Pro His Ser Val 
65                  70                  75                  80  


His Gly Val His Gly Pro Pro Ala Leu Ser Gly Ser Pro Val Ile Ser 
                85                  90                  95      


Asp Ile Ser Leu Ile Arg Leu Ser Pro His Pro Ala Gly Pro Gly Glu 
            100                 105                 110         


Ser Pro Phe Asn Ala Pro His Pro Tyr Val Asn Pro His Met Glu His 
        115                 120                 125             


Tyr Leu Arg Ser Val His Ser Ser Pro Thr Leu Ser Met Ile Ser Ala 
    130                 135                 140                 


Ala Arg Gly Leu Ser Pro Ala Asp Val Ala Gln Glu His Leu Lys Glu 
145                 150                 155                 160 


Arg Gly Leu Phe Gly Leu Pro Ala Pro Gly Thr Thr Pro Ser Asp Tyr 
                165                 170                 175     


Tyr His Gln Met Thr Leu Val Ala Gly His Pro Ala Pro Tyr Gly Asp 
            180                 185                 190         


Leu Leu Met Gln Ser Gly Gly Ala Ala Ser Ala Pro His Leu His Asp 
        195                 200                 205             


Tyr Leu Asn Pro Val Asp Val Ser Arg Phe Ser Ser Pro Arg Val Thr 
    210                 215                 220                 


Pro Arg Leu Ser Arg Lys Arg Ala Leu Ser Ile Ser Pro Leu Ser Asp 
225                 230                 235                 240 


Ala Ser Leu Asp Leu Gln Arg Met Ile Arg Thr Ser Pro Asn Ser Leu 
                245                 250                 255     


Val Ala Tyr Ile Asn Asn Ser Arg Ser Ser Ser Ala Ala Ser Gly Ser 
            260                 265                 270         


Tyr Gly His Leu Ser Ala Gly Ala Leu Ser Pro Ala Phe Thr Phe Pro 
        275                 280                 285             


His Pro Ile Asn Pro Val Ala Tyr Gln Gln Ile Leu Ser Gln Gln Arg 
    290                 295                 300                 


Gly Leu Gly Ser Ala Phe Gly His Thr Pro Pro Leu Ile Gln Pro Ser 
305                 310                 315                 320 


Pro Thr Phe Leu Ala Gln Gln Pro Met Ala Leu Thr Ser Ile Asn Ala 
                325                 330                 335     


Thr Pro Thr Gln Leu Ser Ser Ser Ser Asn Cys Leu Ser Asp Thr Asn 
            340                 345                 350         


Gln Asn Lys Gln Ser Ser Glu Ser Ala Val Ser Ser Thr Val Asn Pro 
        355                 360                 365             


Val Ala Ile His Lys Arg Ser Lys Val Lys Thr Glu Pro Glu Gly Leu 
    370                 375                 380                 


Arg Pro Ala Ser Pro Leu Ala Leu Thr Gln Gly Gln Val Ser Gly His 
385                 390                 395                 400 


Gly Ser Cys Gly Cys Ala Leu Pro Leu Ser Gln Glu Gln Leu Ala Asp 
                405                 410                 415     


Leu Lys Glu Asp Leu Asp Arg Asp Asp Cys Lys Gln Glu Ala Glu Val 
            420                 425                 430         


Val Ile Tyr Glu Thr Asn Cys His Trp Glu Asp Cys Thr Lys Glu Tyr 
        435                 440                 445             


Asp Thr Gln Glu Gln Leu Val His His Ile Asn Asn Glu His Ile His 
    450                 455                 460                 


Gly Glu Lys Lys Glu Phe Val Cys Arg Trp Gln Ala Cys Thr Arg Glu 
465                 470                 475                 480 


Gln Lys Pro Phe Lys Ala Gln Tyr Met Leu Val Val His Met Arg Arg 
                485                 490                 495     


His Thr Gly Glu Lys Pro His Lys Cys Thr Phe Glu Gly Cys Ser Lys 
            500                 505                 510         


Ala Tyr Ser Arg Leu Glu Asn Leu Lys Thr His Leu Arg Ser His Thr 
        515                 520                 525             


Gly Glu Lys Pro Tyr Val Cys Glu His Glu Gly Cys Asn Lys Ala Phe 
    530                 535                 540                 


Ser Asn Ala Ser Asp Arg Ala Lys His Gln Asn Arg Thr His Ser Asn 
545                 550                 555                 560 


Glu Lys Pro Tyr Ile Cys Lys Ile Pro Gly Cys Thr Lys Arg Tyr Thr 
                565                 570                 575     


Asp Pro Ser Ser Leu Arg Lys His Val Lys Thr Val His Gly Pro Asp 
            580                 585                 590         


Ala His Val Thr Lys Lys Gln Arg Asn Asp Val His Leu Arg Thr Pro 
        595                 600                 605             


Leu Leu Lys Glu Asn Gly Asp Ser Glu Ala Gly Thr Glu Pro Gly Gly 
    610                 615                 620                 


Pro Glu Ser Thr Glu Ala Ser Ser Thr Ser Gln Ala Val Glu Asp Cys 
625                 630                 635                 640 


Leu His Val Arg Ala Ile Lys Thr Glu Ser Ser Gly Leu Cys Gln Ser 
                645                 650                 655     


Ser Pro Gly Ala Gln Ser Ser Cys Ser Ser Glu Pro Ser Pro Leu Gly 
            660                 665                 670         


Ser Ala Pro Asn Asn Asp Ser Gly Val Glu Met Pro Gly Thr Gly Pro 
        675                 680                 685             


Gly Ser Leu Gly Asp Leu Thr Ala Leu Asp Asp Thr Pro Pro Gly Ala 
    690                 695                 700                 


Asp Thr Ser Ala Leu Ala Ala Pro Ser Ala Gly Gly Leu Gln Leu Arg 
705                 710                 715                 720 


Lys His Met Thr Thr Met His Arg Phe Glu Gln Leu Lys Lys Glu Lys 
                725                 730                 735     


Leu Lys Ser Leu Lys Asp Ser Cys Ser Trp Ala Gly Pro Thr Pro His 
            740                 745                 750         


Thr Arg Asn Thr Lys Leu Pro Pro Leu Pro Gly Ser Gly Ser Ile Leu 
        755                 760                 765             


Glu Asn Phe Ser Gly Ser Gly Gly Gly Gly Pro Ala Gly Leu Leu Pro 
    770                 775                 780                 


Asn Pro Arg Leu Ser Glu Leu Ser Ala Ser Glu Val Thr Met Leu Ser 
785                 790                 795                 800 


Gln Leu Gln Glu Arg Arg Asp Ser Ser Thr Ser Thr Val Ser Ser Ala 
                805                 810                 815     


Tyr Thr Val Ser Arg Arg Ser Ser Gly Ile Ser Pro Tyr Phe Ser Ser 
            820                 825                 830         


Arg Arg Ser Ser Glu Ala Ser Pro Leu Gly Ala Gly Arg Pro His Asn 
        835                 840                 845             


Ala Ser Ser Ala Asp Ser Tyr Asp Pro Ile Ser Thr Asp Ala Ser Arg 
    850                 855                 860                 


Arg Ser Ser Glu Ala Ser Gln Cys Ser Gly Gly Ser Gly Leu Leu Asn 
865                 870                 875                 880 


Leu Thr Pro Ala Gln Gln Tyr Ser Leu Arg Ala Lys Tyr Ala Ala Ala 
                885                 890                 895     


Thr Gly Gly Pro Pro Pro Thr Pro Leu Pro Gly Leu Glu Arg Met Ser 
            900                 905                 910         


Leu Arg Thr Arg Leu Ala Leu Leu Asp Ala Pro Glu Arg Thr Leu Pro 
        915                 920                 925             


Ala Gly Cys Pro Arg Pro Leu Gly Pro Arg Arg Gly Ser Asp Gly Pro 
    930                 935                 940                 


Thr Tyr Gly His Gly His Ala Gly Ala Ala Pro Ala Phe Pro His Glu 
945                 950                 955                 960 


Ala Pro Gly Gly Gly Ala Arg Arg Ala Ser Asp Pro Val Arg Arg Pro 
                965                 970                 975     


Asp Ala Leu Ser Leu Pro Arg Val Gln Arg Phe His Ser Thr His Asn 
            980                 985                 990         


Val Asn Pro Gly Pro Leu Pro Pro  Cys Ala Asp Arg Arg  Gly Leu Arg 
        995                 1000                 1005             


Leu Gln  Ser His Pro Ser Thr  Asp Gly Gly Leu Ala  Arg Gly Ala 
    1010                 1015                 1020             


Tyr Ser  Pro Arg Pro Pro Ser  Ile Ser Glu Asn Val  Ala Met Glu 
    1025                 1030                 1035             


Ala Val  Ala Ala Gly Val Asp  Gly Ala Gly Pro Glu  Ala Asp Leu 
    1040                 1045                 1050             


Gly Leu  Pro Glu Asp Asp Leu  Val Leu Pro Asp Asp  Val Val Gln 
    1055                 1060                 1065             


Tyr Ile  Lys Ala His Ala Ser  Gly Ala Leu Asp Glu  Gly Thr Gly 
    1070                 1075                 1080             


Gln Val  Tyr Pro Thr Glu Ser  Thr Gly Phe Ser Asp  Asn Pro Arg 
    1085                 1090                 1095             


Leu Pro  Ser Pro Gly Leu His  Gly Gln Arg Arg Met  Val Ala Ala 
    1100                 1105                 1110             


Asp Ser  Asn Val Gly Pro Ser  Ala Pro Met Leu Gly  Gly Cys Gln 
    1115                 1120                 1125             


Leu Gly  Phe Gly Ala Pro Ser  Ser Leu Asn Lys Asn  Asn Met Pro 
    1130                 1135                 1140             


Val Gln  Trp Asn Glu Val Ser  Ser Gly Thr Val Asp  Ala Leu Ala 
    1145                 1150                 1155             


Ser Gln  Val Lys Pro Pro Pro  Phe Pro Gln Gly Asn  Leu Ala Val 
    1160                 1165                 1170             


Val Gln  Gln Lys Pro Ala Phe  Gly Gln Tyr Pro Gly  Tyr Ser Pro 
    1175                 1180                 1185             


Gln Gly  Leu Gln Ala Ser Pro  Gly Gly Leu Asp Ser  Thr Gln Pro 
    1190                 1195                 1200             


His Leu  Gln Pro Arg Ser Gly  Ala Pro Ser Gln Gly  Ile Pro Arg 
    1205                 1210                 1215             


Val Asn  Tyr Met Gln Gln Leu  Arg Gln Pro Val Ala  Gly Ser Gln 
    1220                 1225                 1230             


Cys Pro  Gly Met Thr Thr Thr  Met Ser Pro His Ala  Cys Tyr Gly 
    1235                 1240                 1245             


Gln Val  His Pro Gln Leu Ser  Pro Ser Thr Ile Ser  Gly Ala Leu 
    1250                 1255                 1260             


Asn Gln  Phe Pro Gln Ser Cys  Ser Asn Met Pro Ala  Lys Pro Gly 
    1265                 1270                 1275             


His Leu  Gly His Pro Gln Gln  Thr Glu Val Ala Pro  Asp Pro Thr 
    1280                 1285                 1290             


Thr Met  Gly Asn Arg His Arg  Glu Leu Gly Val Pro  Asp Ser Ala 
    1295                 1300                 1305             


Leu Ala  Gly Val Pro Pro Pro  His Pro Val Gln Ser  Tyr Pro Gln 
    1310                 1315                 1320             


Gln Ser  His His Leu Ala Ala  Ser Met Ser Gln Glu  Gly Tyr His 
    1325                 1330                 1335             


Gln Val  Pro Ser Leu Leu Pro  Ala Arg Gln Pro Gly  Phe Met Glu 
    1340                 1345                 1350             


Pro Gln  Thr Gly Pro Met Gly  Val Ala Thr Ala Gly  Phe Gly Leu 
    1355                 1360                 1365             


Val Gln  Pro Arg Pro Pro Leu  Glu Pro Ser Pro Thr  Gly Arg His 
    1370                 1375                 1380             


Arg Gly  Val Arg Ala Val Gln  Gln Gln Leu Ala Tyr  Ala Arg Ala 
    1385                 1390                 1395             


Thr Gly  His Ala Met Ala Ala  Met Pro Ser Ser Gln  Glu Thr Ala 
    1400                 1405                 1410             


Glu Ala  Val Pro Lys Gly Ala  Met Gly Asn Met Gly  Ser Val Pro 
    1415                 1420                 1425             


Pro Gln  Pro Pro Pro Gln Asp  Ala Gly Gly Ala Pro  Asp His Ser 
    1430                 1435                 1440             


Met Leu  Tyr Tyr Tyr Gly Gln  Ile His Met Tyr Glu  Gln Asp Gly 
    1445                 1450                 1455             


Gly Leu  Glu Asn Leu Gly Ser  Cys Gln Val Met Arg  Ser Gln Pro 
    1460                 1465                 1470             


Pro Gln  Pro Gln Ala Cys Gln  Asp Ser Ile Gln Pro  Gln Pro Leu 
    1475                 1480                 1485             


Pro Ser  Pro Gly Val Asn Gln  Val Ser Ser Thr Val  Asp Ser Gln 
    1490                 1495                 1500             


Leu Leu  Glu Ala Pro Gln Ile  Asp Phe Asp Ala Ile  Met Asp Asp 
    1505                 1510                 1515             


Gly Asp  His Ser Ser Leu Phe  Ser Gly Ala Leu Ser  Pro Ser Leu 
    1520                 1525                 1530             


Leu His  Ser Leu Ser Gln Asn  Ser Ser Arg Leu Thr  Thr Pro Arg 
    1535                 1540                 1545             


Asn Ser  Leu Thr Leu Pro Ser  Ile Pro Ala Gly Ile  Ser Asn Met 
    1550                 1555                 1560             


Ala Val  Gly Asp Met Ser Ser  Met Leu Thr Ser Leu  Ala Glu Glu 
    1565                 1570                 1575             


Ser Lys  Phe Leu Asn Met Met  Thr 
    1580                 1585     


<210>  58
<211>  1580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, GLI3

<400>  58

Met Glu Ala Gln Ser His Ser Ser Thr Thr Thr Glu Lys Lys Lys Val 
1               5                   10                  15      


Glu Asn Ser Ile Val Lys Cys Ser Thr Arg Thr Asp Val Ser Glu Lys 
            20                  25                  30          


Ala Val Ala Ser Ser Thr Thr Ser Asn Glu Asp Glu Ser Pro Gly Gln 
        35                  40                  45              


Thr Tyr His Arg Glu Arg Arg Asn Ala Ile Thr Met Gln Pro Gln Asn 
    50                  55                  60                  


Val Gln Gly Leu Ser Lys Val Ser Glu Glu Pro Ser Thr Ser Ser Asp 
65                  70                  75                  80  


Glu Arg Ala Ser Leu Ile Lys Lys Glu Ile His Gly Ser Leu Pro His 
                85                  90                  95      


Val Ala Glu Pro Ser Val Pro Tyr Arg Gly Thr Val Phe Ala Met Asp 
            100                 105                 110         


Pro Arg Asn Gly Tyr Met Glu Pro His Tyr His Pro Pro His Leu Phe 
        115                 120                 125             


Pro Ala Phe His Pro Pro Val Pro Ile Asp Ala Arg His His Glu Gly 
    130                 135                 140                 


Arg Tyr His Tyr Asp Pro Ser Pro Ile Pro Pro Leu His Met Thr Ser 
145                 150                 155                 160 


Ala Leu Ser Ser Ser Pro Thr Tyr Pro Asp Leu Pro Phe Ile Arg Ile 
                165                 170                 175     


Ser Pro His Arg Asn Pro Thr Ala Ala Ser Glu Ser Pro Phe Ser Pro 
            180                 185                 190         


Pro His Pro Tyr Ile Asn Pro Tyr Met Asp Tyr Ile Arg Ser Leu His 
        195                 200                 205             


Ser Ser Pro Ser Leu Ser Met Ile Ser Ala Thr Arg Gly Leu Ser Pro 
    210                 215                 220                 


Thr Asp Ala Pro His Ala Gly Val Ser Pro Ala Glu Tyr Tyr His Gln 
225                 230                 235                 240 


Met Ala Leu Leu Thr Gly Gln Arg Ser Pro Tyr Ala Asp Ile Ile Pro 
                245                 250                 255     


Ser Ala Ala Thr Ala Gly Thr Gly Ala Ile His Met Glu Tyr Leu His 
            260                 265                 270         


Ala Met Asp Ser Thr Arg Phe Ser Ser Pro Arg Leu Ser Ala Arg Pro 
        275                 280                 285             


Ser Arg Lys Arg Thr Leu Ser Ile Ser Pro Leu Ser Asp His Ser Phe 
    290                 295                 300                 


Asp Leu Gln Thr Met Ile Arg Thr Ser Pro Asn Ser Leu Val Thr Ile 
305                 310                 315                 320 


Leu Asn Asn Ser Arg Ser Ser Ser Ser Ala Ser Gly Ser Tyr Gly His 
                325                 330                 335     


Leu Ser Ala Ser Ala Ile Ser Pro Ala Leu Ser Phe Thr Tyr Ser Ser 
            340                 345                 350         


Ala Pro Val Ser Leu His Met His Gln Gln Ile Leu Ser Arg Gln Gln 
        355                 360                 365             


Ser Leu Gly Ser Ala Phe Gly His Ser Pro Pro Leu Ile His Pro Ala 
    370                 375                 380                 


Pro Thr Phe Pro Thr Gln Arg Pro Ile Pro Gly Ile Pro Thr Val Leu 
385                 390                 395                 400 


Asn Pro Val Gln Val Ser Ser Gly Pro Ser Glu Ser Ser Gln Asn Lys 
                405                 410                 415     


Pro Thr Ser Glu Ser Ala Val Ser Ser Thr Gly Asp Pro Met His Asn 
            420                 425                 430         


Lys Arg Ser Lys Ile Lys Pro Asp Glu Asp Leu Pro Ser Pro Gly Ala 
        435                 440                 445             


Arg Gly Gln Gln Glu Gln Pro Glu Gly Thr Thr Leu Val Lys Glu Glu 
    450                 455                 460                 


Gly Asp Lys Asp Glu Ser Lys Gln Glu Pro Glu Val Ile Tyr Glu Thr 
465                 470                 475                 480 


Asn Cys His Trp Glu Gly Cys Ala Arg Glu Phe Asp Thr Gln Glu Gln 
                485                 490                 495     


Leu Val His His Ile Asn Asn Asp His Ile His Gly Glu Lys Lys Glu 
            500                 505                 510         


Phe Val Cys Arg Trp Leu Asp Cys Ser Arg Glu Gln Lys Pro Phe Lys 
        515                 520                 525             


Ala Gln Tyr Met Leu Val Val His Met Arg Arg His Thr Gly Glu Lys 
    530                 535                 540                 


Pro His Lys Cys Thr Phe Glu Gly Cys Thr Lys Ala Tyr Ser Arg Leu 
545                 550                 555                 560 


Glu Asn Leu Lys Thr His Leu Arg Ser His Thr Gly Glu Lys Pro Tyr 
                565                 570                 575     


Val Cys Glu His Glu Gly Cys Asn Lys Ala Phe Ser Asn Ala Ser Asp 
            580                 585                 590         


Arg Ala Lys His Gln Asn Arg Thr His Ser Asn Glu Lys Pro Tyr Val 
        595                 600                 605             


Cys Lys Ile Pro Gly Cys Thr Lys Arg Tyr Thr Asp Pro Ser Ser Leu 
    610                 615                 620                 


Arg Lys His Val Lys Thr Val His Gly Pro Glu Ala His Val Thr Lys 
625                 630                 635                 640 


Lys Gln Arg Gly Asp Ile His Pro Arg Pro Pro Pro Pro Arg Asp Ser 
                645                 650                 655     


Gly Ser His Ser Gln Ser Arg Ser Pro Gly Arg Pro Thr Gln Gly Ala 
            660                 665                 670         


Leu Gly Glu Gln Gln Asp Leu Ser Asn Thr Thr Ser Lys Arg Glu Glu 
        675                 680                 685             


Cys Leu Gln Val Lys Thr Val Lys Ala Glu Lys Pro Met Thr Ser Gln 
    690                 695                 700                 


Pro Ser Pro Gly Gly Gln Ser Ser Cys Ser Ser Gln Gln Ser Pro Ile 
705                 710                 715                 720 


Ser Asn Tyr Ser Asn Ser Gly Leu Glu Leu Pro Leu Thr Asp Gly Gly 
                725                 730                 735     


Ser Ile Gly Asp Leu Ser Ala Ile Asp Glu Thr Pro Ile Met Asp Ser 
            740                 745                 750         


Thr Ile Ser Thr Ala Thr Thr Ala Leu Ala Leu Gln Ala Arg Arg Asn 
        755                 760                 765             


Pro Ala Gly Thr Lys Trp Met Glu His Val Lys Leu Glu Arg Leu Lys 
    770                 775                 780                 


Gln Val Asn Gly Met Phe Pro Arg Leu Asn Pro Ile Leu Pro Pro Lys 
785                 790                 795                 800 


Ala Pro Ala Val Ser Pro Leu Ile Gly Asn Gly Thr Gln Ser Asn Asn 
                805                 810                 815     


Thr Cys Ser Leu Gly Gly Pro Met Thr Leu Leu Pro Gly Arg Ser Asp 
            820                 825                 830         


Leu Ser Gly Val Asp Val Thr Met Leu Asn Met Leu Asn Arg Arg Asp 
        835                 840                 845             


Ser Ser Ala Ser Thr Ile Ser Ser Ala Tyr Leu Ser Ser Arg Arg Ser 
    850                 855                 860                 


Ser Gly Ile Ser Pro Cys Phe Ser Ser Arg Arg Ser Ser Glu Ala Ser 
865                 870                 875                 880 


Gln Ala Glu Gly Arg Pro Gln Asn Val Ser Val Ala Asp Ser Tyr Asp 
                885                 890                 895     


Pro Ile Ser Thr Asp Ala Ser Arg Arg Ser Ser Glu Ala Ser Gln Ser 
            900                 905                 910         


Asp Gly Leu Pro Ser Leu Leu Ser Leu Thr Pro Ala Gln Gln Tyr Arg 
        915                 920                 925             


Leu Lys Ala Lys Tyr Ala Ala Ala Thr Gly Gly Pro Pro Pro Thr Pro 
    930                 935                 940                 


Leu Pro Asn Met Glu Arg Met Ser Leu Lys Thr Arg Leu Ala Leu Leu 
945                 950                 955                 960 


Gly Asp Ala Leu Glu Pro Gly Val Ala Leu Pro Pro Val His Ala Pro 
                965                 970                 975     


Arg Arg Cys Ser Asp Gly Gly Ala His Gly Tyr Gly Arg Arg His Leu 
            980                 985                 990         


Gln Pro His Asp Ala Pro Gly His  Gly Val Arg Arg Ala  Ser Asp Pro 
        995                 1000                 1005             


Val Arg  Thr Gly Ser Glu Gly  Leu Ala Leu Pro Arg  Val Pro Arg 
    1010                 1015                 1020             


Phe Ser  Ser Leu Ser Ser Cys  Asn Pro Pro Ala Met  Ala Thr Ser 
    1025                 1030                 1035             


Ala Glu  Lys Arg Ser Leu Val  Leu Gln Asn Tyr Thr  Arg Pro Glu 
    1040                 1045                 1050             


Gly Gly  Gln Ser Arg Asn Phe  His Ser Ser Pro Cys  Pro Pro Ser 
    1055                 1060                 1065             


Ile Thr  Glu Asn Val Thr Leu  Glu Ser Leu Thr Met  Asp Ala Asp 
    1070                 1075                 1080             


Ala Asn  Leu Asn Asp Glu Asp  Phe Leu Pro Asp Asp  Val Val Gln 
    1085                 1090                 1095             


Tyr Leu  Asn Ser Gln Asn Gln  Ala Gly Tyr Glu Gln  His Phe Pro 
    1100                 1105                 1110             


Ser Ala  Leu Pro Asp Asp Ser  Lys Val Pro His Gly  Pro Gly Asp 
    1115                 1120                 1125             


Phe Asp  Ala Pro Gly Leu Pro  Asp Ser His Ala Gly  Gln Gln Phe 
    1130                 1135                 1140             


His Ala  Leu Glu Gln Pro Cys  Pro Glu Gly Ser Lys  Thr Asp Leu 
    1145                 1150                 1155             


Pro Ile  Gln Trp Asn Glu Val  Ser Ser Gly Ser Ala  Asp Leu Ser 
    1160                 1165                 1170             


Ser Ser  Lys Leu Lys Cys Gly  Pro Arg Pro Ala Val  Pro Gln Thr 
    1175                 1180                 1185             


Arg Ala  Phe Gly Phe Cys Asn  Gly Met Val Val His  Pro Gln Asn 
    1190                 1195                 1200             


Pro Leu  Arg Ser Gly Pro Ala  Gly Gly Tyr Gln Thr  Leu Gly Glu 
    1205                 1210                 1215             


Asn Ser  Asn Pro Tyr Gly Gly  Pro Glu His Leu Met  Leu His Asn 
    1220                 1225                 1230             


Ser Pro  Gly Ser Gly Thr Ser  Gly Asn Ala Phe His  Glu Gln Pro 
    1235                 1240                 1245             


Cys Lys  Ala Pro Gln Tyr Gly  Asn Cys Leu Asn Arg  Gln Pro Val 
    1250                 1255                 1260             


Ala Pro  Gly Ala Leu Asp Gly  Ala Cys Gly Ala Gly  Ile Gln Ala 
    1265                 1270                 1275             


Ser Lys  Leu Lys Ser Thr Pro  Met Gln Gly Ser Gly  Gly Gln Leu 
    1280                 1285                 1290             


Asn Phe  Gly Leu Pro Val Ala  Pro Asn Glu Ser Ala  Gly Ser Met 
    1295                 1300                 1305             


Val Asn  Gly Met Gln Asn Gln  Asp Pro Val Gly Gln  Gly Tyr Leu 
    1310                 1315                 1320             


Ala His  Gln Leu Leu Gly Asp  Ser Met Gln His Pro  Gly Ala Gly 
    1325                 1330                 1335             


Arg Pro  Gly Gln Gln Met Leu  Gly Gln Ile Ser Ala  Thr Ser His 
    1340                 1345                 1350             


Ile Asn  Ile Tyr Gln Gly Pro  Glu Ser Cys Leu Pro  Gly Ala His 
    1355                 1360                 1365             


Gly Met  Gly Ser Gln Pro Ser  Ser Leu Ala Val Val  Arg Gly Tyr 
    1370                 1375                 1380             


Gln Pro  Cys Ala Ser Phe Gly  Gly Ser Arg Arg Gln  Ala Met Pro 
    1385                 1390                 1395             


Arg Asp  Ser Leu Ala Leu Gln  Ser Gly Gln Leu Ser  Asp Thr Ser 
    1400                 1405                 1410             


Gln Thr  Cys Arg Val Asn Gly  Ile Lys Met Glu Met  Lys Gly Gln 
    1415                 1420                 1425             


Pro His  Pro Leu Cys Ser Asn  Leu Gln Asn Tyr Ser  Gly Gln Phe 
    1430                 1435                 1440             


Tyr Asp  Gln Thr Val Gly Phe  Ser Gln Gln Asp Thr  Lys Ala Gly 
    1445                 1450                 1455             


Ser Phe  Ser Ile Ser Asp Ala  Ser Cys Leu Leu Gln  Gly Thr Ser 
    1460                 1465                 1470             


Ala Lys  Asn Ser Glu Leu Leu  Ser Pro Gly Ala Asn  Gln Val Thr 
    1475                 1480                 1485             


Ser Thr  Val Asp Ser Leu Asp  Ser His Asp Leu Glu  Gly Val Gln 
    1490                 1495                 1500             


Ile Asp  Phe Asp Ala Ile Ile  Asp Asp Gly Asp His  Ser Ser Leu 
    1505                 1510                 1515             


Met Ser  Gly Ala Leu Ser Pro  Ser Ile Ile Gln Asn  Leu Ser His 
    1520                 1525                 1530             


Ser Ser  Ser Arg Leu Thr Thr  Pro Arg Ala Ser Leu  Pro Phe Pro 
    1535                 1540                 1545             


Ala Leu  Ser Met Ser Thr Thr  Asn Met Ala Ile Gly  Asp Met Ser 
    1550                 1555                 1560             


Ser Leu  Leu Thr Ser Leu Ala  Glu Glu Ser Lys Phe  Leu Ala Val 
    1565                 1570                 1575             


Met Gln  
    1580 


<210>  59
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, ETV1

<400>  59

Met Asp Gly Phe Tyr Asp Gln Gln Val Pro Tyr Met Val Thr Asn Ser 
1               5                   10                  15      


Gln Arg Gly Arg Asn Cys Asn Glu Lys Pro Thr Asn Val Arg Lys Arg 
            20                  25                  30          


Lys Phe Ile Asn Arg Asp Leu Ala His Asp Ser Glu Glu Leu Phe Gln 
        35                  40                  45              


Asp Leu Ser Gln Leu Gln Glu Thr Trp Leu Ala Glu Val Ala Phe His 
    50                  55                  60                  


Gly Leu Pro Leu Lys Ile Lys Lys Glu Pro His Ser Pro Cys Ser Glu 
65                  70                  75                  80  


Ile Ser Ser Ala Cys Ser Gln Glu Gln Pro Phe Lys Phe Ser Tyr Gly 
                85                  90                  95      


Glu Lys Cys Leu Tyr Asn Val Ser Ala Tyr Asp Gln Lys Pro Gln Val 
            100                 105                 110         


Gly Met Arg Pro Ser Asn Pro Pro Thr Pro Ser Ser Thr Pro Val Ser 
        115                 120                 125             


Pro Leu His His Ala Ser Pro Asn Ser Thr His Thr Pro Lys Pro Asp 
    130                 135                 140                 


Arg Ala Phe Pro Ala His Leu Pro Pro Ser Gln Ser Ile Pro Asp Ser 
145                 150                 155                 160 


Ser Tyr Pro Met Asp His Arg Phe Arg Arg Gln Leu Ser Glu Pro Cys 
                165                 170                 175     


Asn Ser Phe Pro Pro Leu Pro Thr Met Pro Arg Glu Gly Arg Pro Met 
            180                 185                 190         


Tyr Gln Arg Gln Met Ser Glu Pro Asn Ile Pro Phe Pro Pro Gln Gly 
        195                 200                 205             


Phe Lys Gln Glu Tyr His Asp Pro Val Tyr Glu His Asn Thr Met Val 
    210                 215                 220                 


Gly Ser Ala Ala Ser Gln Ser Phe Pro Pro Pro Leu Met Ile Lys Gln 
225                 230                 235                 240 


Glu Pro Arg Asp Phe Ala Tyr Asp Ser Glu Val Pro Ser Cys His Ser 
                245                 250                 255     


Ile Tyr Met Arg Gln Glu Gly Phe Leu Ala His Pro Ser Arg Thr Glu 
            260                 265                 270         


Gly Cys Met Phe Glu Lys Gly Pro Arg Gln Phe Tyr Asp Asp Thr Cys 
        275                 280                 285             


Val Val Pro Glu Lys Phe Asp Gly Asp Ile Lys Gln Glu Pro Gly Met 
    290                 295                 300                 


Tyr Arg Glu Gly Pro Thr Tyr Gln Arg Arg Gly Ser Leu Gln Leu Trp 
305                 310                 315                 320 


Gln Phe Leu Val Ala Leu Leu Asp Asp Pro Ser Asn Ser His Phe Ile 
                325                 330                 335     


Ala Trp Thr Gly Arg Gly Met Glu Phe Lys Leu Ile Glu Pro Glu Glu 
            340                 345                 350         


Val Ala Arg Arg Trp Gly Ile Gln Lys Asn Arg Pro Ala Met Asn Tyr 
        355                 360                 365             


Asp Lys Leu Ser Arg Ser Leu Arg Tyr Tyr Tyr Glu Lys Gly Ile Met 
    370                 375                 380                 


Gln Lys Val Ala Gly Glu Arg Tyr Val Tyr Lys Phe Val Cys Asp Pro 
385                 390                 395                 400 


Glu Ala Leu Phe Ser Met Ala Phe Pro Asp Asn Gln Arg Pro Leu Leu 
                405                 410                 415     


Lys Thr Asp Met Glu Arg His Ile Asn Glu Glu Asp Thr Val Pro Leu 
            420                 425                 430         


Ser His Phe Asp Glu Ser Met Ala Tyr Met Pro Glu Gly Gly Cys Cys 
        435                 440                 445             


Asn Pro His Pro Tyr Asn Glu Gly Tyr Val Tyr 
    450                 455                 


<210>  60
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, ETV2

<400>  60

Met Asp Leu Trp Asn Trp Asp Glu Ala Ser Pro Gln Glu Val Pro Pro 
1               5                   10                  15      


Gly Asn Lys Leu Ala Gly Leu Glu Gly Ala Lys Leu Gly Phe Cys Phe 
            20                  25                  30          


Pro Asp Leu Ala Leu Gln Gly Asp Thr Pro Thr Ala Thr Ala Glu Thr 
        35                  40                  45              


Cys Trp Lys Gly Pro Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu 
    50                  55                  60                  


His Asp Gly Ala Arg Ser Ser Cys Ile Arg Trp Thr Gly Asn Ser Arg 
65                  70                  75                  80  


Glu Phe Gln Leu Cys Asp Pro Lys Glu Val Ala Arg Leu Trp Gly Glu 
                85                  90                  95      


Arg Lys Arg Lys Pro Gly Met Asn Tyr Glu Lys Leu Ser Arg Gly Leu 
            100                 105                 110         


Arg Tyr Tyr Tyr Arg Arg Asp Ile Val Arg Lys Ser Gly Gly Arg Lys 
        115                 120                 125             


Tyr Thr Tyr Arg Phe Gly Gly Arg Val Pro Ser Leu Ala Tyr Pro Asp 
    130                 135                 140                 


Cys Ala Gly Gly Gly Arg Gly Ala Glu Thr Gln 
145                 150                 155 


<210>  61
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, ETV3

<400>  61

Met Lys Ala Gly Cys Ser Ile Val Glu Lys Pro Glu Gly Gly Gly Gly 
1               5                   10                  15      


Tyr Gln Phe Pro Asp Trp Ala Tyr Lys Thr Glu Ser Ser Pro Gly Ser 
            20                  25                  30          


Arg Gln Ile Gln Leu Trp His Phe Ile Leu Glu Leu Leu Gln Lys Glu 
        35                  40                  45              


Glu Phe Arg His Val Ile Ala Trp Gln Gln Gly Glu Tyr Gly Glu Phe 
    50                  55                  60                  


Val Ile Lys Asp Pro Asp Glu Val Ala Arg Leu Trp Gly Arg Arg Lys 
65                  70                  75                  80  


Cys Lys Pro Gln Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr 
                85                  90                  95      


Tyr Tyr Asn Lys Arg Ile Leu His Lys Thr Lys Gly Lys Arg Phe Thr 
            100                 105                 110         


Tyr Lys Phe Asn Phe Asn Lys Leu Val Met Pro Asn Tyr Pro Phe Ile 
        115                 120                 125             


Asn Ile Arg Ser Ser Gly Lys Ile Gln Thr Leu Leu Val Gly Asn 
    130                 135                 140             


<210>  62
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       RUNX1

<400>  62

Met Ala Ser Asp Ser Ile Phe Glu Ser Phe Pro Ser Tyr Pro Gln Cys 
1               5                   10                  15      


Phe Met Arg Glu Cys Ile Leu Gly Met Asn Pro Ser Arg Asp Val His 
            20                  25                  30          


Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro Ser Thr Ala Leu Ser 
        35                  40                  45              


Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly Ala Pro Asp Ala Gly 
    50                  55                  60                  


Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp Arg Ser Met Val Glu 
65                  70                  75                  80  


Val Leu Ala Asp His Pro Gly Glu Leu Val Arg Thr Asp Ser Pro Asn 
                85                  90                  95      


Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg Cys Asn Lys Thr Leu 
            100                 105                 110         


Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp Val Pro Asp Gly Thr 
        115                 120                 125             


Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn Tyr Ser Ala Glu Leu 
    130                 135                 140                 


Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val Ala Arg Phe Asn Asp 
145                 150                 155                 160 


Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys Ser Phe Thr Leu Thr 
                165                 170                 175     


Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala Thr Tyr His Arg Ala 
            180                 185                 190         


Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro Arg Arg His Arg Gln 
        195                 200                 205             


Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu Ser Phe Ser Glu Arg 
    210                 215                 220                 


Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala Met Arg Val Ser Pro 
225                 230                 235                 240 


His His Pro Ala Pro Thr Pro Asn Pro Arg Ala Ser Leu Asn His Ser 
                245                 250                 255     


Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met Gln Asp Thr Arg Gln 
            260                 265                 270         


Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Gln Tyr Leu 
        275                 280                 285             


Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala Thr Pro Ile Ser Pro 
    290                 295                 300                 


Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala Glu Leu Ser Ser Arg 
305                 310                 315                 320 


Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser Asp Pro Arg Gln Phe 
                325                 330                 335     


Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met His Tyr Pro Gly Ala 
            340                 345                 350         


Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly Ile Gly Ile Gly Met 
        355                 360                 365             


Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr Tyr Leu Pro Pro Pro 
    370                 375                 380                 


Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro Phe Gln Ala Ser Ser 
385                 390                 395                 400 


Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala Gly Ser Tyr Gln Phe 
                405                 410                 415     


Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg Ile Leu Pro Pro Cys 
            420                 425                 430         


Thr Asn Ala Ser Thr Gly Ser Ala Leu Leu Asn Pro Ser Leu Pro Asn 
        435                 440                 445             


Gln Ser Asp Val Val Glu Ala Glu Gly Ser His Ser Asn Ser Pro Thr 
    450                 455                 460                 


Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala Val Trp Arg Pro Tyr 
465                 470                 475                 480 


<210>  63
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       RUNX2

<400>  63

Met Ala Ser Asn Ser Leu Phe Ser Thr Val Thr Pro Cys Gln Gln Asn 
1               5                   10                  15      


Phe Phe Trp Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro Ser Ser 
            20                  25                  30          


Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val Ala Ala 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Glu Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Arg Leu Arg Pro Pro 
                85                  90                  95      


His Asp Asn Arg Thr Met Val Glu Ile Ile Ala Asp His Pro Ala Glu 
            100                 105                 110         


Leu Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Ser 
        115                 120                 125             


His Trp Arg Cys Asn Lys Thr Leu Pro Val Ala Phe Lys Val Val Ala 
    130                 135                 140                 


Leu Gly Glu Val Pro Asp Gly Thr Val Val Thr Val Met Ala Gly Asn 
145                 150                 155                 160 


Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Ser Ala Val Met Lys 
                165                 170                 175     


Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly 
            180                 185                 190         


Arg Gly Lys Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro 
        195                 200                 205             


Gln Val Ala Thr Tyr His Arg Ala Ile Lys Val Thr Val Asp Gly Pro 
    210                 215                 220                 


Arg Glu Pro Arg Arg His Arg Gln Lys Leu Asp Asp Ser Lys Pro Ser 
225                 230                 235                 240 


Leu Phe Ser Asp Arg Leu Ser Asp Leu Gly Arg Ile Pro His Pro Ser 
                245                 250                 255     


Met Arg Val Gly Val Pro Pro Gln Asn Pro Arg Pro Ser Leu Asn Ser 
            260                 265                 270         


Ala Pro Ser Pro Phe Asn Pro Gln Gly Gln Ser Gln Ile Thr Asp Pro 
        275                 280                 285             


Arg Gln Ala Gln Ser Ser Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Pro 
    290                 295                 300                 


Ser Tyr Leu Ser Gln Met Thr Ser Pro Ser Ile His Ser Thr Thr Pro 
305                 310                 315                 320 


Leu Ser Ser Thr Arg Gly Thr Gly Leu Pro Ala Ile Thr Asp Val Pro 
                325                 330                 335     


Arg Arg Ile Ser Gly Ala Ser Glu Leu Gly Pro Phe Ser Asp Pro Arg 
            340                 345                 350         


Gln Phe Pro Ser Ile Ser Ser Leu Thr Glu Ser Arg Phe Ser Asn Pro 
        355                 360                 365             


Arg Met His Tyr Pro Ala Thr Phe Thr Tyr Thr Pro Pro Val Thr Ser 
    370                 375                 380                 


Gly Met Ser Leu Gly Met Ser Ala Thr Thr His Tyr His Thr Tyr Leu 
385                 390                 395                 400 


Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ser Gln Ser Gly Pro Phe Gln 
                405                 410                 415     


Thr Ser Ser Thr Pro Tyr Leu Tyr Tyr Gly Thr Ser Ser Gly Ser Tyr 
            420                 425                 430         


Gln Phe Pro Met Val Pro Gly Gly Asp Arg Ser Pro Ser Arg Met Leu 
        435                 440                 445             


Pro Pro Cys Thr Thr Thr Ser Asn Gly Ser Thr Leu Leu Asn Pro Asn 
    450                 455                 460                 


Leu Pro Asn Gln Asn Asp Gly Val Asp Ala Asp Gly Ser His Ser Ser 
465                 470                 475                 480 


Ser Pro Thr Val Leu Asn Ser Ser Gly Arg Met Asp Glu Ser Val Trp 
                485                 490                 495     


Arg Pro Tyr 
            


<210>  64
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       RUNX3

<400>  64

Met Arg Ile Pro Val Asp Pro Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Pro Ala Phe Pro Cys Gly Gly Gly Gly Gly Lys Met Gly Glu Asn 
            20                  25                  30          


Ser Gly Ala Leu Ser Ala Gln Ala Ala Val Gly Pro Gly Gly Arg Ala 
        35                  40                  45              


Arg Pro Glu Val Arg Ser Met Val Asp Val Leu Ala Asp His Ala Gly 
    50                  55                  60                  


Glu Leu Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro 
65                  70                  75                  80  


Ser His Trp Arg Cys Asn Lys Thr Leu Pro Val Ala Phe Lys Val Val 
                85                  90                  95      


Ala Leu Gly Asp Val Pro Asp Gly Thr Val Val Thr Val Met Ala Gly 
            100                 105                 110         


Asn Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Ser Ala Val Met 
        115                 120                 125             


Lys Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser 
    130                 135                 140                 


Gly Arg Gly Lys Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro 
145                 150                 155                 160 


Thr Gln Val Ala Thr Tyr His Arg Ala Ile Lys Val Thr Val Asp Gly 
                165                 170                 175     


Pro Arg Glu Pro Arg Arg His Arg Gln Lys Leu Glu Asp Gln Thr Lys 
            180                 185                 190         


Pro Phe Pro Asp Arg Phe Gly Asp Leu Glu Arg Leu Arg Met Arg Val 
        195                 200                 205             


Thr Pro Ser Thr Pro Ser Pro Arg Gly Ser Leu Ser Thr Thr Ser His 
    210                 215                 220                 


Phe Ser Ser Gln Pro Gln Thr Pro Ile Gln Gly Thr Ser Glu Leu Asn 
225                 230                 235                 240 


Pro Phe Ser Asp Pro Arg Gln Phe Asp Arg Ser Phe Pro Thr Leu Pro 
                245                 250                 255     


Thr Leu Thr Glu Ser Arg Phe Pro Asp Pro Arg Met His Tyr Pro Gly 
            260                 265                 270         


Ala Met Ser Ala Ala Phe Pro Tyr Ser Ala Thr Pro Ser Gly Thr Ser 
        275                 280                 285             


Ile Ser Ser Leu Ser Val Ala Gly Met Pro Ala Thr Ser Arg Phe His 
    290                 295                 300                 


His Thr Tyr Leu Pro Pro Pro Tyr Pro Gly Ala Pro Gln Asn Gln Ser 
305                 310                 315                 320 


Gly Pro Phe Gln Ala Asn Pro Ser Pro Tyr His Leu Tyr Tyr Gly Thr 
                325                 330                 335     


Ser Ser Gly Ser Tyr Gln Phe Ser Met Val Ala Gly Ser Ser Ser Gly 
            340                 345                 350         


Gly Asp Arg Ser Pro Thr Arg Met Leu Ala Ser Cys Thr Ser Ser Ala 
        355                 360                 365             


Ala Ser Val Ala Ala Gly Asn Leu Met Asn Pro Ser Leu Gly Gly Gln 
    370                 375                 380                 


Ser Asp Gly Val Glu Ala Asp Gly Ser His Ser Asn Ser Pro Thr Ala 
385                 390                 395                 400 


Leu Ser Thr Pro Gly Arg Met Asp Glu Ala Val Trp Arg Pro Tyr 
                405                 410                 415 


<210>  65
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, MAFB

<400>  65

Met Ala Ala Glu Leu Ser Met Gly Pro Glu Leu Pro Thr Ser Pro Leu 
1               5                   10                  15      


Ala Met Glu Tyr Val Asn Asp Phe Asp Leu Leu Lys Phe Asp Val Lys 
            20                  25                  30          


Lys Glu Pro Leu Gly Arg Ala Glu Arg Pro Gly Arg Pro Cys Thr Arg 
        35                  40                  45              


Leu Gln Pro Ala Gly Ser Val Ser Ser Thr Pro Leu Ser Thr Pro Cys 
    50                  55                  60                  


Ser Ser Val Pro Ser Ser Pro Ser Phe Ser Pro Thr Glu Gln Lys Thr 
65                  70                  75                  80  


His Leu Glu Asp Leu Tyr Trp Met Ala Ser Asn Tyr Gln Gln Met Asn 
                85                  90                  95      


Pro Glu Ala Leu Asn Leu Thr Pro Glu Asp Ala Val Glu Ala Leu Ile 
            100                 105                 110         


Gly Ser His Pro Val Pro Gln Pro Leu Gln Ser Phe Asp Ser Phe Arg 
        115                 120                 125             


Gly Ala His His His His His His His His Pro His Pro His His Ala 
    130                 135                 140                 


Tyr Pro Gly Ala Gly Val Ala His Asp Glu Leu Gly Pro His Ala His 
145                 150                 155                 160 


Pro His His His His His His Gln Ala Ser Pro Pro Pro Ser Ser Ala 
                165                 170                 175     


Ala Ser Pro Ala Gln Gln Leu Pro Thr Ser His Pro Gly Pro Gly Pro 
            180                 185                 190         


His Ala Thr Ala Ser Ala Thr Ala Ala Gly Gly Asn Gly Ser Val Glu 
        195                 200                 205             


Asp Arg Phe Ser Asp Asp Gln Leu Val Ser Met Ser Val Arg Glu Leu 
    210                 215                 220                 


Asn Arg His Leu Arg Gly Phe Thr Lys Asp Glu Val Ile Arg Leu Lys 
225                 230                 235                 240 


Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser Cys Arg 
                245                 250                 255     


Tyr Lys Arg Val Gln Gln Lys His His Leu Glu Asn Glu Lys Thr Gln 
            260                 265                 270         


Leu Ile Gln Gln Val Glu Gln Leu Lys Gln Glu Val Ser Arg Leu Ala 
        275                 280                 285             


Arg Glu Arg Asp Ala Tyr Lys Val Lys Cys Glu Lys Leu Ala Asn Ser 
    290                 295                 300                 


Gly Phe Arg Glu Ala Gly Ser Thr Ser Asp Ser Pro Ser Ser Pro Glu 
305                 310                 315                 320 


Phe Phe Leu 
            


<210>  66
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, 
       TFAP2C

<400>  66

Met Leu Trp Lys Ile Thr Asp Asn Val Lys Tyr Glu Glu Asp Cys Glu 
1               5                   10                  15      


Asp Arg His Asp Gly Ser Ser Asn Gly Asn Pro Arg Val Pro His Leu 
            20                  25                  30          


Ser Ser Ala Gly Gln His Leu Tyr Ser Pro Ala Pro Pro Leu Ser His 
        35                  40                  45              


Thr Gly Val Ala Glu Tyr Gln Pro Pro Pro Tyr Phe Pro Pro Pro Tyr 
    50                  55                  60                  


Gln Gln Leu Ala Tyr Ser Gln Ser Ala Asp Pro Tyr Ser His Leu Gly 
65                  70                  75                  80  


Glu Ala Tyr Ala Ala Ala Ile Asn Pro Leu His Gln Pro Ala Pro Thr 
                85                  90                  95      


Gly Ser Gln Gln Gln Ala Trp Pro Gly Arg Gln Ser Gln Glu Gly Ala 
            100                 105                 110         


Gly Leu Pro Ser His His Gly Arg Pro Ala Gly Leu Leu Pro His Leu 
        115                 120                 125             


Ser Gly Leu Glu Ala Gly Ala Val Ser Ala Arg Arg Asp Ala Tyr Arg 
    130                 135                 140                 


Arg Ser Asp Leu Leu Leu Pro His Ala His Ala Leu Asp Ala Ala Gly 
145                 150                 155                 160 


Leu Ala Glu Asn Leu Gly Leu His Asp Met Pro His Gln Met Asp Glu 
                165                 170                 175     


Val Gln Asn Val Asp Asp Gln His Leu Leu Leu His Asp Gln Thr Val 
            180                 185                 190         


Ile Arg Lys Gly Pro Ile Ser Met Thr Lys Asn Pro Leu Asn Leu Pro 
        195                 200                 205             


Cys Gln Lys Glu Leu Val Gly Ala Val Met Asn Pro Thr Glu Val Phe 
    210                 215                 220                 


Cys Ser Val Pro Gly Arg Leu Ser Leu Leu Ser Ser Thr Ser Lys Tyr 
225                 230                 235                 240 


Lys Val Thr Val Ala Glu Val Gln Arg Arg Leu Ser Pro Pro Glu Cys 
                245                 250                 255     


Leu Asn Ala Ser Leu Leu Gly Gly Val Leu Arg Arg Ala Lys Ser Lys 
            260                 265                 270         


Asn Gly Gly Arg Ser Leu Arg Glu Lys Leu Asp Lys Ile Gly Leu Asn 
        275                 280                 285             


Leu Pro Ala Gly Arg Arg Lys Ala Ala His Val Thr Leu Leu Thr Ser 
    290                 295                 300                 


Leu Val Glu Gly Glu Ala Val His Leu Ala Arg Asp Phe Ala Tyr Val 
305                 310                 315                 320 


Cys Glu Ala Glu Phe Pro Ser Lys Pro Val Ala Glu Tyr Leu Thr Arg 
                325                 330                 335     


Pro His Leu Gly Gly Arg Asn Glu Met Ala Ala Arg Lys Asn Met Leu 
            340                 345                 350         


Leu Ala Ala Gln Gln Leu Cys Lys Glu Phe Thr Glu Leu Leu Ser Gln 
        355                 360                 365             


Asp Arg Thr Pro His Gly Thr Ser Arg Leu Ala Pro Val Leu Glu Thr 
    370                 375                 380                 


Asn Ile Gln Asn Cys Leu Ser His Phe Ser Leu Ile Thr His Gly Phe 
385                 390                 395                 400 


Gly Ser Gln Ala Ile Cys Ala Ala Val Ser Ala Leu Gln Asn Tyr Ile 
                405                 410                 415     


Lys Glu Ala Leu Ile Val Ile Asp Lys Ser Tyr Met Asn Pro Gly Asp 
            420                 425                 430         


Gln Ser Pro Ala Asp Ser Asn Lys Thr Leu Glu Lys Met Glu Lys His 
        435                 440                 445             


Arg Lys 
    450 


<210>  67
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising transcription factor DNA-binding domain, E2F1

<400>  67

Met Ala Leu Ala Gly Ala Pro Ala Gly Gly Pro Cys Ala Pro Ala Leu 
1               5                   10                  15      


Glu Ala Leu Leu Gly Ala Gly Ala Leu Arg Leu Leu Asp Ser Ser Gln 
            20                  25                  30          


Ile Val Ile Ile Ser Ala Ala Gln Asp Ala Ser Ala Pro Pro Ala Pro 
        35                  40                  45              


Thr Gly Pro Ala Ala Pro Ala Ala Gly Pro Cys Asp Pro Asp Leu Leu 
    50                  55                  60                  


Leu Phe Ala Thr Pro Gln Ala Pro Arg Pro Thr Pro Ser Ala Pro Arg 
65                  70                  75                  80  


Pro Ala Leu Gly Arg Pro Pro Val Lys Arg Arg Leu Asp Leu Glu Thr 
                85                  90                  95      


Asp His Gln Tyr Leu Ala Glu Ser Ser Gly Pro Ala Arg Gly Arg Gly 
            100                 105                 110         


Arg His Pro Gly Lys Gly Val Lys Ser Pro Gly Glu Lys Ser Arg Tyr 
        115                 120                 125             


Glu Thr Ser Leu Asn Leu Thr Thr Lys Arg Phe Leu Glu Leu Leu Ser 
    130                 135                 140                 


His Ser Ala Asp Gly Val Val Asp Leu Asn Trp Ala Ala Glu Val Leu 
145                 150                 155                 160 


Lys Val Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn Val Leu Glu Gly 
                165                 170                 175     


Ile Gln Leu Ile Ala Lys Lys Ser Lys Asn His Ile Gln Trp Leu Gly 
            180                 185                 190         


Ser His Thr Thr Val Gly Val Gly Gly Arg Leu Glu Gly Leu Thr Gln 
        195                 200                 205             


Asp Leu Arg Gln Leu Gln Glu Ser Glu Gln Gln Leu Asp His Leu Met 
    210                 215                 220                 


Asn Ile Cys Thr Thr Gln Leu Arg Leu Leu Ser Glu Asp Thr Asp Ser 
225                 230                 235                 240 


Gln Arg Leu Ala Tyr Val Thr Cys Gln Asp Leu Arg Ser Ile Ala Asp 
                245                 250                 255     


Pro Ala Glu Gln Met Val Met Val Ile Lys Ala Pro Pro Glu Thr Gln 
            260                 265                 270         


Leu Gln Ala Val Asp Ser Ser Glu Asn Phe Gln Ile Ser Leu Lys Ser 
        275                 280                 285             


Lys Gln Gly Pro Ile Asp Val Phe Leu Cys Pro Glu Glu Thr Val Gly 
    290                 295                 300                 


Gly Ile Ser Pro Gly Lys Thr Pro Ser Gln Glu Val Thr Ser Glu Glu 
305                 310                 315                 320 


Glu Asn Arg Ala Thr Asp Ser Ala Thr Ile Val Ser Pro Pro Pro Ser 
                325                 330                 335     


Ser Pro Pro Ser Ser Leu Thr Thr Asp Pro Ser Gln Ser Leu Leu Ser 
            340                 345                 350         


Leu Glu Gln Glu Pro Leu Leu Ser Arg Met Gly Ser Leu Arg Ala Pro 
        355                 360                 365             


Val Asp Glu Asp Arg Leu Ser Pro Leu Val Ala Ala Asp Ser Leu Leu 
    370                 375                 380                 


Glu His Val Arg Glu Asp Phe Ser Gly Leu Leu Pro Glu Glu Phe Ile 
385                 390                 395                 400 


Ser Leu Ser Pro Pro His Glu Ala Leu Asp Tyr His Phe Gly Leu Glu 
                405                 410                 415     


Glu Gly Glu Gly Ile Arg Asp Leu Phe Asp Cys Asp Phe Gly Asp Leu 
            420                 425                 430         


Thr Pro Leu Asp Phe 
        435         


<210>  68
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, SOX2

<400>  68
atgtacaaca tgatggagac ggagctgaag ccgccgggcc cgcagcaaac ttcggggggc       60

ggcggcggca actccaccgc ggcggcggcc ggcggcaacc agaaaaacag cccggaccgc      120

gtcaagcggc ccatgaatgc cttcatggtg tggtcccgcg ggcagcggcg caagatggcc      180

caggagaacc ccaagatgca caactcggag atcagcaagc gcctgggcgc cgagtggaaa      240

cttttgtcgg agacggagaa gcggccgttc atcgacgagg ctaagcggct gcgagcgctg      300

cacatgaagg agcacccgga ttataaatac cggccccggc ggaaaaccaa gacgctcatg      360

aagaaggata agtacacgct gcccggcggg ctgctggccc ccggcggcaa tagcatggcg      420

agcggggtcg gggtgggcgc cggcctgggc gcgggcgtga accagcgcat ggacagttac      480

gcgcacatga acggctggag caacggcagc tacagcatga tgcaggacca gctgggc         537


<210>  69
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, MYC

<400>  69
atcatccagg actgtatgtg gagcggcttc tcggccgccg ccaagctcgt ctcagagaag       60

ctggcctcct accaggctgc gcgcaaagac agcggcagcc cgaaccccgc ccgcggccac      120

agcgtctgct ccacctccag cttgtacctg caggatctga gcgccgccgc ctcagagtgc      180

atcgacccct cggtggtctt cccctaccct ctcaacgaca gcagctcgcc caagtcctgc      240

gcctcgcaag actccagcgc cttctctccg tcctcggatt ctctgctctc ctcgacggag      300

tcctccccgc agggcagccc cgagcccctg gtgctccatg aggagacacc gcccaccacc      360

agcagcgact ctgaggagga acaagaagat gaggaagaaa tcgatgttgt ttctgtggaa      420

aagaggcagg ctcctggcaa aaggtcagag tctggatcac cttctgctgg aggccacagc      480

aaacctcctc acagcccact ggtcctcaag aggtgccacg tctccacaca tcagcacaac      540

tacgcagcgc ctccctccac tcggaaggac tatcctgctg ccaagagggt caagttggac      600

agtgtcagag tcctgagaca gatcagcaac aaccgaaaat gcaccagccc caggtcctcg      660

gacaccgagg agaatgtcaa gaggcgaaca cacaacgtct tggagcgcca gaggaggaac      720

gagctaaaac ggagcttttt tgccctgcgt gaccagatcc cggagttgga aaacaatgaa      780

aaggccccca aggtagttat ccttaaaaaa gccacagcat acatcctgtc cgtccaagca      840

gaggagcaaa agctcatttc tgaagaggac ttgttgcgga aacgacgaga acagttgaaa      900

cacaaacttg aacagctacg gaactcttgt gcg                                   933


<210>  70
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, MYCN

<400>  70
atgccgagct gctccacgtc caccatgccg ggcatgatct gcaagaaccc agacctcgag       60

tttgactcgc tacagccctg cttctacccg gacgaagatg acttctactt cggcggcccc      120

gactcgaccc ccccggggga ggacatctgg aagaagtttg agctgctgcc cacgcccccg      180

ctgtcgccca gccgtggctt cgcggagcac agctccgagc ccccgagctg ggtcacggag      240

atgctgcttg agaacgagct gtggggcagc ccggccgagg aggacgcgtt cggcctgggg      300

ggactgggtg gcctcacccc caacccggtc atcctccagg actgcatgtg gagcggcttc      360

tccgcccgcg agaagctgga gcgcgccgtg agcgagaagc tgcagcacgg ccgcgggccg      420

ccaaccgccg gttccaccgc ccagtccccg ggagccggcg ccgccagccc tgcgggtcgc      480

gggcacggcg gggctgcggg agccggccgc gccggggccg ccctgcccgc cgagctcgcc      540

cacccggccg ccgagtgcgt ggatcccgcc gtggtcttcc cctttcccgt gaacaagcgc      600

gagccagcgc ccgtgcccgc agccccggcc agtgccccgg cggcgggccc tgcggtcgcc      660

tcgggggcgg gtattgccgc cccagccggg gccccggggg tcgcccctcc gcgcccaggc      720

ggccgccaga ccagcggcgg cgaccacaag gccctcagta cctccggaga ggacaccctg      780

agcgattcag atgatgaaga tgatgaagag gaagatgaag aggaagaaat cgacgtggtc      840

actgtggaga agcggcgttc ctcctccaac accaaggctg tcaccacatt caccatcact      900

gtgcgtccca agaacgcagc cctgggtccc gggagggctc agtccagcga gctgatcctc      960

aaacgatgcc ttcccatcca ccagcagcac aactatgccg ccccctctcc ctacgtggag     1020

agtgaggatg cacccccaca gaagaagata aagagcgagg cgtccccacg tccgctcaag     1080

agtgtcatcc ccccaaaggc taagagcttg agcccccgaa actctgactc ggaggacagt     1140

gagcgtcgca gaaaccacaa catcctggag cgccagcgcc gcaacgacct tcggtccagc     1200

tttctcacgc tcagggacca cgtgccggag ttggtaaaga atgagaaggc cgccaaggtg     1260

gtcattttga aaaaggccac tgagtatgtc cactccctcc aggccgagga gcaccagctt     1320

ttgctggaaa aggaaaaatt gcaggcaaga cagcagcagt tgctaaagaa aattgaacac     1380

gctcggactt gc                                                         1392


<210>  71
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, TEAD1

<400>  71
attgagccca gcagctggag cggcagtgag agccctgccg aaaacatgga aaggatgagt       60

gactctgcag ataagccaat tgacaatgat gcagaagggg tctggagccc cgacatcgag      120

caaagctttc aggaggccct ggctatctat ccaccatgtg ggaggaggaa aatcatctta      180

tcagacgaag gcaaaatgta tggtaggaat gaattgatag ccagatacat caaactcagg      240

acaggcaaga cgaggaccag aaaacaggtg tctagtcaca ttcaggttct tgccagaagg      300

aaatctcgtg attttcattc caagctaaag gatcagactg caaaggataa ggccctgcag      360

cacatggcgg ccatgtcctc agcccagatc gtctcggcca ctgccattca taacaagctg      420

gggctgcctg ggattccacg cccgaccttc ccaggggcgc cggggttctg gccgggaatg      480

attcaaacag ggcagcca                                                    498


<210>  72
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, TEAD2

<400>  72
atgggggaac cccgggctgg ggccgccctg gacgatggca gcggctggac gggcagtgag       60

gaaggcagtg aggagggtac cggcggcagt gagggggctg ggggtgacgg gggcccggat      120

gcagaggggg tgtggagccc agacattgag cagagcttcc aggaggccct ggccatctat      180

ccaccctgcg gccgccggaa aataattttg tctgatgaag gcaagatgta tggtcggaat      240

gaactgatcg cccgctacat caagctgaga acggggaaga cccgaactcg aaaacaggtt      300

tctagtcaca tccaggtttt ggcccgaagg aaatcaaggg aaatccagtc caagttgaag      360

gaccaggttt ccaaggacaa ggctttccag acaatggcaa ccatgtcctc tgcccagctc      420

atctccgcgc cttctctgca ggccaaactg ggtcccactg gtcctcaggc ctctgagctt      480

ttccagtttt ggtctggagg atctgggccc ccctggaatg ttccagatgt gaagccattc      540

tcacagacac cgttcacctt gtcactgact cccccatcta ctgacctccc agggtacgag      600

cccccccaag ccctctcacc cctgccccca cctaccccat cgcccccagc ctggcaggct      660

cggggcctgg gcaccgcccg gttgcagctg gtagagttct cagccttcgt ggaaccgcca      720

gatgcagttg attcttacca gaggcacctg ttcgtgcaca tcagccagca ctgccccagc      780

cccggagcgc cgccgctcga gagtgtggac gtccggcaga tctacgacaa attccctgag      840

aaaaagggtg gcctccgaga gctatatgat cgtggccccc cccatgcctt cttcctggtc      900

aagttctggg cggacctgaa ctggggccca agtggtgagg aggcaggggc cggtggcagc      960

atcagcagtg gtggcttcta cggagtgagc agccagtatg agagcctgga acacatgacc     1020

ctcacctgtt cctccaaggt ctgctctttt ggcaagcagg tggtggagaa ggtggagacg     1080

gaacgggccc agctggagga cggcagattt gtgtaccgcc tgctgcgctc gcccatgtgc     1140

gagtacctgg tgaatttctt gcacaagttg cggcagctgc ctgagcgata catgatgaac     1200

agcgtcctgg aaaacttcac catcctccag gtggtgacaa acagagacac ccaggaactg     1260

ctgctctgca ccgcctatgt cttcgaggtc tccaccagcg agcgtggggc ccagcatcac     1320

atttaccgcc tggtcaggga c                                               1341


<210>  73
<211>  1305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, TEAD3

<400>  73
atagcgtcca acagctggaa cgccagcagc agccccgggg aggcccggga ggatgggccc       60

gagggcctgg acaaggggct ggacaacgat gcggagggcg tgtggagccc ggacatcgag      120

cagagcttcc aggaggccct ggccatctac ccgccctgcg gccggcggaa gatcatcctg      180

tcagacgagg gcaagatgta cggccgaaat gagttgattg cacgctatat taaactgagg      240

acggggaaga ctcggacgag aaaacaggtg tccagccaca tacaggttct agctcggaag      300

aaggtgcggg agtaccaggt tggcatcaag gccatgaacc tggaccaggt ctccaaggac      360

aaagcccttc agagcatggc gtccatgtcc tctgcccaga tcgtctctgc cagtgtcctg      420

cagaacaagt tcagcccacc ttcccctctg ccccaggccg tcttctccac ttcctcgcgg      480

ttctggagca gcccccctct cctgggacag cagcctggac cctctcagga catcaagccc      540

tttgcacagc cagcctaccc catccagccg cccctgccgc cgacgctcag cagttatgag      600

cccctggccc cgctcccctc agctgctgcc tctgtgcctg tgtggcagga ccgtaccatt      660

gcctcctccc ggctgcggct cctggagtat tcagccttca tggaggtgca gcgagaccct      720

gacacgtaca gcaaacacct gtttgtgcac atcggccaga cgaaccccgc cttctcagac      780

ccacccctgg aggcagtaga tgtgcgccag atctatgaca aattccccga gaaaaaggga      840

ggattgaagg agctctatga gaaggggccc cctaatgcct tcttccttgt caagttctgg      900

gccgacctca acagcaccat ccaggagggc ccgggagcct tctatggggt cagctctcag      960

tacagctctg ctgatagcat gaccatcagc gtctccacca aggtgtgctc ctttggcaaa     1020

caggtggtag agaaggtgga gactgagtat gccaggctgg agaacgggcg ctttgtgtac     1080

cgtatccacc gctcgcccat gtgcgagtac atgatcaact tcatccacaa gctgaagcac     1140

ctgcccgaga agtacatgat gaacagcgtg ctggagaact tcaccatcct gcaggtggtc     1200

acgagccggg actcccagga gaccctgctt gtcattgctt ttgtcttcga agtctccacc     1260

agtgagcacg gggcccagca ccatgtctac aagctcgtca aagac                     1305


<210>  74
<211>  1173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, TEAD4

<400>  74
ttggagggca cggccggcac cattacctcc aacgagtgga gctctcccac ctcccctgag       60

gggagcaccg cctctggggg cagtcaggca ctggacaagc ccatcgacaa tgacgcagag      120

ggcgtgtgga gcccggatat tgagcagagt ttccaggagg ccctcgccat ctacccgccc      180

tgtggcaggc gcaaaatcat cctgtcggac gagggcaaga tgtatggtcg gaacgagctg      240

attgcccgct acatcaagct ccggacaggg aagacccgca ccaggaagca ggtctccagc      300

cacatccagg tgctggctcg tcgcaaagct cgcgagatcc aggccaagct aaagttttgg      360

caaggagctt tgccaggcca agccggaacg tcccatgatg tgaagccttt ctctcagcaa      420

acctatgctg tccagcctcc gctgcctctg ccagggtttg agtctcctgc agggcccgcc      480

ccatcgccct ctgcgccccc ggcaccccca tggcagggcc gcagcgtggc cagctccaag      540

ctctggatgt tggagttctc tgccttcctg gagcagcagc aggacccgga cacgtacaac      600

aagcacctgt tcgtgcacat tggccagtcc agcccaagct acagcgaccc ctacctcgaa      660

gccgtggaca tccgccaaat ctatgacaaa ttcccggaga aaaagggtgg actcaaggat      720

ctcttcgaac ggggaccctc caatgccttt tttcttgtga agttctgggc agacctcaac      780

accaacatcg aggatgaagg cagctccttc tatggggtct ccagccagta tgagagcccc      840

gagaacatga tcatcacctg ctccacgaag gtctgctctt tcggcaagca ggtggtggag      900

aaagttgaga cagagtatgc tcgctatgag aatggacact actcttaccg catccaccgg      960

tccccgctct gtgagtacat gatcaacttc atccacaagc tcaagcacct ccctgagaag     1020

tacatgatga acagcgtgct ggagaacttc accatcctgc aggtggtcac caacagagac     1080

acacaggaga ccttgctgtg cattgcctat gtctttgagg tgtcagccag tgagcacggg     1140

gctcagcacc acatctacag gctggtgaaa gaa                                  1173


<210>  75
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, FOXA1

<400>  75
atgttaggaa ctgtgaagat ggaagggcat gaaaccagcg actggaacag ctactacgca       60

gacacgcagg aggcctactc ctccgtcccg gtcagcaaca tgaactcagg cctgggctcc      120

atgaactcca tgaacaccta catgaccatg aacaccatga ctacgagcgg caacatgacc      180

ccggcgtcct tcaacatgtc ctatgccaac ccgggcctag gggccggcct gagtcccggc      240

gcagtagccg gcatgccggg gggctcggcg ggcgccatga acagcatgac tgcggccggc      300

gtgacggcca tgggtacggc gctgagcccg agcggcatgg gcgccatggg tgcgcagcag      360

gcggcctcca tgaatggcct gggcccctac gcggccgcca tgaacccgtg catgagcccc      420

atggcgtacg cgccgtccaa cctgggccgc agccgcgcgg gcggcggcgg cgacgccaag      480

acgttcaagc gcagctaccc gcacgccaag ccgccctact cgtacatctc gctcatcacc      540

atggccatcc agcaggcgcc cagcaagatg ctcacgctga gcgagatcta ccagtggatc      600

atggacctct tcccctatta ccggcagaac cagcagcgct ggcagaactc catccgccac      660

tcgctgtcct tcaatgactg cttcgtcaag gtggcacgct ccccggacaa gccgggcaag      720

ggctcctact ggacgctgca cccggactcc ggcaacatgt tcgagaacgg ctgctacttg      780

cgccgccaga agcgcttcaa gtgcgagaag cagccggggg ccggcggcgg gggcgggagc      840

ggaagcgggg gcagcggcgc caagggcggc cctgagagcc gcaaggaccc ctctggcgcc      900

tctaacccca gcgccgactc gcccctccat cggggtgtgc acgggaagac cggccagcta      960

gagggcgcgc cggcccccgg gcccgccgcc agcccccaga ctctggacca cagtggggcg     1020

acggcgacag ggggcgcctc ggagttgaag actccagcct cctcaactgc gccccccata     1080

agctccgggc ccggggcgct ggcctctgtg cccgcctctc acccggcaca cggcttggca     1140

ccccacgagt cccagctgca cctgaaaggg gacccccact actccttcaa ccacccgttc     1200

tccatcaaca acctcatgtc ctcctcggag cagcagcata agctggactt caaggcatac     1260

gaacaggcac tgcaatactc gccttacggc tctacgttgc ccgccagcct gcctctaggc     1320

agcgcctcgg tgaccaccag gagccccatc gagccctcag ccctggagcc ggcgtactac     1380

caaggtgtgt attccagacc cgtcctaaac acttcctag                            1419


<210>  76
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, FOXA2

<400>  76
atgcactcgg cttccagtat gctgggagcg gtgaagatgg aagggcacga gccgtccgac       60

tggagcagct actatgcaga gcccgagggc tactcctccg tgagcaacat gaacgccggc      120

ctggggatga acggcatgaa cacgtacatg agcatgtcgg cggccgccat gggcagcggc      180

tcgggcaaca tgagcgcggg ctccatgaac atgtcgtcgt acgtgggcgc tggcatgagc      240

ccgtccctgg cggggatgtc ccccggcgcg ggcgccatgg cgggcatggg cggctcggcc      300

ggggcggccg gcgtggcggg catggggccg cacttgagtc ccagcctgag cccgctcggg      360

gggcaggcgg ccggggccat gggcggcctg gccccctacg ccaacatgaa ctccatgagc      420

cccatgtacg ggcaggcggg cctgagccgc gcccgcgacc ccaagaccta caggcgcagc      480

tacacgcacg caaagccgcc ctactcgtac atctcgctca tcaccatggc catccagcag      540

agccccaaca agatgctgac gctgagcgag atctaccagt ggatcatgga cctcttcccc      600

ttctaccggc agaaccagca gcgctggcag aactccatcc gccactcgct ctccttcaac      660

gactgtttcc tgaaggtgcc ccgctcgccc gacaagcccg gcaagggctc cttctggacc      720

ctgcaccctg actcgggcaa catgttcgag aacggctgct acctgcgccg ccagaagcgc      780

ttcaagtgcg agaagcagct ggcgctgaag gaggccgcag gcgccgccgg cagcggcaag      840

aaggcggccg ccggagccca ggcctcacag gctcaactcg gggaggccgc cgggccggcc      900

tccgagactc cggcgggcac cgagtcgcct cactcgagcg cctccccgtg ccaggagcac      960

aagcgagggg gcctgggaga gctgaagggg acgccggctg cggcgctgag ccccccagag     1020

ccggcgccct ctcccgggca gcagcagcag gccgcggccc acctgctggg cccgccccac     1080

cacccgggcc tgccgcctga ggcccacctg aagccggaac accactacgc cttcaaccac     1140

ccgttctcca tcaacaacct catgtcctcg gagcagcagc accaccacag ccaccaccac     1200

caccaacccc acaaaatgga cctcaaggcc tacgaacagg tgatgcacta ccccggctac     1260

ggttccccca tgcctggcag cttggccatg ggcccggtca cgaacaaaac gggcctggac     1320

gcctcgcccc tggccgcaga tacctcctac taccaggggg tgtactcccg gcccattatg     1380

aactcctct                                                             1389


<210>  77
<211>  1284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, ELK1

<400>  77
atggacccat ctgtgacgct gtggcagttt ctgctgcagc tgctgagaga gcaaggcaat       60

ggccacatca tctcctggac ttcacgggat ggtggtgaat tcaagctggt ggatgcagag      120

gaggtggccc ggctgtgggg gctacgcaag aacaagacca acatgaatta cgacaagctc      180

agccgggcct tgcggtacta ctatgacaag aacatcatcc gcaaggtgag cggccagaag      240

ttcgtctaca agtttgtgtc ctaccctgag gtcgcagggt gctccactga ggactgcccg      300

ccccagccag aggtgtctgt tacctccacc atgccaaatg tggcccctgc tgctatacat      360

gccgccccag gggacactgt ctctggaaag ccaggcacac ccaagggtgc aggaatggca      420

ggcccaggcg gtttggcacg cagcagccgg aacgagtaca tgcgctcggg cctctattcc      480

accttcacca tccagtctct gcagccgcag ccaccccctc atcctcggcc tgctgtggtg      540

ctccccagtg cagctcctgc aggggcagca gcgcccccct cggggagcag gagcaccagt      600

ccaagcccct tggaggcctg tctggaggct gaagaggccg gcttgcctct gcaggtcatc      660

ctgaccccgc ccgaggcccc aaacctgaaa tcggaagagc ttaatgtgga gccgggtttg      720

ggccgggctt tgcccccaga agtgaaagta gaagggccca aggaagagtt ggaagttgcg      780

ggggagagag ggtttgtgcc agaaaccacc aaggccgagc cagaagtccc tccacaggag      840

ggcgtgccag cccggctgcc cgcggttgtt atggacaccg cagggcaggc gggcggccat      900

gcggcttcca gccctgagat ctcccagccg cagaagggcc ggaagccccg ggacctagag      960

cttccactca gcccgagcct gctaggtggg ccgggacccg aacggacccc aggatcggga     1020

agtggctccg gcctccaggc tccggggccg gcgctgaccc catccctgct tcctacgcat     1080

acattgaccc cggtgctgct gacacccagc tcgctgcctc ctagcattca cttctggagc     1140

accctgagtc ccattgcgcc ccgtagcccg gccaagctct ccttccagtt tccatccagt     1200

ggcagcgccc aggtgcacat cccttctatc agcgtggatg gcctctcgac ccccgtggtg     1260

ctctccccag ggccccagaa gcca                                            1284


<210>  78
<211>  1221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, ELK3

<400>  78
atggagagtg caatcacgct gtggcagttc ctgttgcagt tgctgctgga tcagaaacat       60

gagcatttga tctgctggac ctcgaacgat ggtgaattca agctcctcaa agcagaagaa      120

gtggccaagc tgtggggact ccgaaaaaac aaaacaaata tgaactatga taagctgagc      180

agagccctgc gatactatta tgacaagaac atcatcaaga aggtgatcgg gcagaagttt      240

gtgtacaagt ttgtctcttt cccggagatc ctgaagatgg atcctcacgc ggtggagatc      300

agccgggaga gccttctgct gcaggacagc gactgcaagg cgtctccgga gggccgcgag      360

gcccacaaac acggcctggc cgccctcaga agcacgagcc gcaacgaata catccactca      420

ggcctgtact cgtccttcac cattaattcc ctgcagaacc caccagacgc cttcaaggcc      480

atcaagacgg agaagctgga ggagccgccc gaagacagcc cccccgtgga agaagtcagg      540

actgtgatca ggtttgtgac caataaaacc gacaagcacg tcaccaggcc ggtggtgtcc      600

ctgccttcca cgtcagaggc tgcggcggcg tccgccttcc tggcctcgtc cgtctcggcc      660

aagatctcct ctttaatgtt gccaaacgct gccagtattt catccgcctc acccttctca      720

tctcggtccc cgtccctgtc ccccaactca cccctccctt ctgaacacag aagcctcttc      780

ctggaggccg cctgccatga ctccgattcc ctggagccct tgaacctgtc atcgggctcc      840

aagaccaagt ctccatctct tcccccaaag gccaaaaaac ccaaaggctt ggaaatctca      900

gcgcccccgc tggtgctctc cggcaccgac atcggctcca tcgccctcaa cagcccagcc      960

ctcccctcgg gatccctcac cccagccttc ttcaccgcac agacaccaaa tggattgctt     1020

ctgactccga gtccactgct ctccagcata catttctgga gcagccttag tccagttgct     1080

ccgctgagtc ctgccaggct gcaagggcca agcacgctgt tccagttccc cacactgctt     1140

aatggccaca tgccagtgcc aatccccagt ctggacagag ctgcttctcc agtactgctt     1200

tcttcaaact ctcagaaatc c                                               1221


<210>  79
<211>  1293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, ELK4

<400>  79
atggacagtg ctatcaccct gtggcagttc cttcttcagc tcctgcagaa gcctcagaac       60

aagcacatga tctgttggac ctctaatgat gggcagttta agcttttgca ggcagaagag      120

gtggctcgtc tctgggggat tcgcaagaac aagcctaaca tgaattatga caaactcagc      180

cgagccctca gatactatta tgtaaagaat atcatcaaaa aagtgaatgg tcagaagttt      240

gtgtacaagt ttgtctctta tccagagatt ttgaacatgg atccaatgac agtgggcagg      300

attgagggtg actgtgaaag tttaaacttc agtgaagtca gcagcagttc caaagatgtg      360

gagaatggag ggaaagataa accacctcag cctggtgcca agacctctag ccgcaatgac      420

tacatacact ctggcttata ttcttcattt actctcaact ctttgaactc ctccaatgta      480

aagcttttca aattgataaa gactgagaat ccagccgaga aactggcaga gaaaaaatct      540

cctcaggagc ccacaccatc tgtcatcaaa tttgtcacga caccttccaa aaagccaccg      600

gttgaacctg ttgctgccac catttcaatt ggcccaagta tttctccatc ttcagaagaa      660

actatccaag ctttggagac attggtttcc ccaaaactgc cttccctgga agccccaacc      720

tctgcctcta acgtaatgac tgcttttgcc accacaccac ccatttcgtc cataccccct      780

ttgcaggaac ctcccagaac accttcacca ccactgagtt ctcacccaga catcgacaca      840

gacattgatt cagtggcttc tcagccaatg gaacttccag agaatttgtc actggagcct      900

aaagaccagg attcagtctt gctagaaaag gacaaagtaa ataattcatc aagatccaag      960

aaacccaaag ggttagaact ggcacccacc cttgtgatca cgagcagtga tccaagccca     1020

ctgggaatac tgagcccatc tctccctaca gcttctctta caccagcatt tttttcacag     1080

acacccatca tactgactcc aagccccttg ctctccagta tccacttctg gagtactctc     1140

agtcctgttg ctcccctaag tccagccaga ctgcaaggtg ctaacacact tttccagttt     1200

ccttctgtac tgaacagtca tgggccattc actctgtctg ggctggatgg accttccacc     1260

cctggcccat tttccccaga cctacagaag aca                                  1293


<210>  80
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, SRF

<400>  80
atgttaccga cccaagctgg ggccgcggcg gctctgggcc ggggctcggc cctggggggc       60

agcctgaacc ggaccccgac ggggcggccg ggcggcggcg gcgggacacg cggggctaac      120

gggggccggg tccccgggaa tggcgcgggg ctcgggcccg gccgcctgga gcgggaggct      180

gcggcagcgg cggcaaccac cccggcgccc accgcggggg ccctctacag cggcagcgag      240

ggcgactcgg agtcgggcga ggaggaggag ctgggcgccg agcggcgcgg cctgaagcgg      300

agcctgagcg agatggagat cggtatggtg gtcggtgggc ccgaggcgtc ggcagcggcc      360

accgggggct acgggccggt gagcggcgcg gtgagcgggg ccaagccggg taagaagacc      420

cggggccgcg tgaagatcaa gatggagttc atcgacaaca agctgcggcg ctacacgacc      480

ttcagcaaga ggaagacggg catcatgaag aaggcctatg agctgtccac gctgacaggg      540

acacaggtgc tgttgctggt ggccagtgag acaggccatg tgtatacctt tgccacccga      600

aaactgcagc ccatgatcac cagtgagacc ggcaaggcac tgattcagac ctgcctcaac      660

tcgccagact ctccaccccg ttcagacccc acaacagacc agagaatgag tgccactggc      720

tttgaagaga cagatctcac ctaccaggtg tcggagtctg acagcagtgg ggagaccaag      780

gacacactga agccggcgtt cacagtcacc aacctgccgg gtacaacctc caccatccaa      840

acagcaccta gcacctctac caccatgcaa gtcagcagcg gcccctcctt tcccatcacc      900

aactacctgg caccagtgtc tgctagtgtc agccccagtg ctgtcagcag tgccaatggg      960

actgtgctga agagtacagg cagcggccct gtctcctctg ggggccttat gcagctgcct     1020

accagcttca ccctcatgcc tggtggggca gtggcccagc aggtcccagt gcaggccatt     1080

caagtgcacc aggccccaca gcaagcgtct ccctcccgtg acagcagcac agacctcacg     1140

cagacctcct ccagcgggac agtgacgctg cccgccacca tcatgacgtc atccgtgccc     1200

acaactgtgg gtggccacat gatgtaccct agcccgcatg cggtgatgta tgcccccacc     1260

tcgggcctgg gtgatggcag cctcaccgtg ctgaatgcct tctcccaggc accatccacc     1320

atgcaggtgt cacacagcca ggtccaggag ccaggtggcg tcccccaggt gttcctgaca     1380

gcatcatctg ggacagtgca gatccctgtt tcagcagttc agctccacca gatggctgtg     1440

atagggcagc aggccgggag cagcagcaac ctcaccgagc tacaggtggt gaacctggac     1500

accgcccaca gcaccaagag tgaa                                            1524


<210>  81
<211>  2403
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, FOXM1

<400>  81
atgaaaacta gcccccgtcg gccactgatt ctcaaaagac ggaggctgcc ccttcctgtt       60

caaaatgccc caagtgaaac atcagaggag gaacctaaga gatcccctgc ccaacaggag      120

tctaatcaag cagaggcctc caaggaagtg gcagagtcca actcttgcaa gtttccagct      180

gggatcaaga ttattaacca ccccaccatg cccaacacgc aagtagtggc catccccaac      240

aatgctaata ttcacagcat catcacagca ctgactgcca agggaaaaga gagtggcagt      300

agtgggccca acaaattcat cctcatcagc tgtgggggag ccccaactca gcctccagga      360

ctccggcctc aaacccaaac cagctatgat gccaaaagga cagaagtgac cctggagacc      420

ttgggaccaa aacctgcagc tagggatgtg aatcttccta gaccacctgg agccctttgc      480

gagcagaaac gggagacctg tgcagatggt gaggcagcag gctgcactat caacaatagc      540

ctatccaaca tccagtggct tcgaaagatg agttctgatg gactgggctc ccgcagcatc      600

aagcaagaga tggaggaaaa ggagaattgt cacctggagc agcgacaggt taaggttgag      660

gagccttcga gaccatcagc gtcctggcag aactctgtgt ctgagcggcc accctactct      720

tacatggcca tgatacaatt cgccatcaac agcactgaga ggaagcgcat gactttgaaa      780

gacatctata cgtggattga ggaccacttt ccctacttta agcacattgc caagccaggc      840

tggaagaact ccatccgcca caacctttcc ctgcacgaca tgtttgtccg ggagacgtct      900

gccaatggca aggtctcctt ctggaccatt caccccagtg ccaaccgcta cttgacattg      960

gaccaggtgt ttaagccact ggacccaggg tctccacaat tgcccgagca cttggaatca     1020

cagcagaaac gaccgaatcc agagctccgc cggaacatga ccatcaaaac cgaactcccc     1080

ctgggcgcac ggcggaagat gaagccactg ctaccacggg tcagctcata cctggtacct     1140

atccagttcc cggtgaacca gtcactggtg ttgcagccct cggtgaaggt gccattgccc     1200

ctggcggctt ccctcatgag ctcagagctt gcccgccata gcaagcgagt ccgcattgcc     1260

cccaaggttt ttggggaaca ggtggtgttt ggttacatga gtaagttctt tagtggcgat     1320

ctgcgagatt ttggtacacc catcaccagc ttgtttaatt ttatctttct ttgtttatca     1380

gtgctgctag ctgaggaggg gatagctcct ctttcttctg caggaccagg gaaagaggag     1440

aaactcctgt ttggagaagg gttttctcct ttgcttccag ttcagactat caaggaggaa     1500

gaaatccagc ctggggagga aatgccacac ttagcgagac ccatcaaagt ggagagccct     1560

cccttggaag agtggccctc cccggcccca tctttcaaag aggaatcatc tcactcctgg     1620

gaggattcgt cccaatctcc caccccaaga cccaagaagt cctacagtgg gcttaggtcc     1680

ccaacccggt gtgtctcgga aatgcttgtg attcaacaca gggagaggag ggagaggagc     1740

cggtctcgga gaaaacagca tctactgcct ccctgtgtgg atgagccgga gctgctcttc     1800

tcagaggggc ccagtacttc ccgctgggcc gcagagctcc cgttcccagc agactcctct     1860

gaccctgcct cccagctcag ctactcccag gaagtgggag gaccttttaa gacacccatt     1920

aaggaaacgc tgcccatctc ctccaccccg agcaaatctg tcctccccag aacccctgaa     1980

tcctggaggc tcacgccccc agccaaagta gggggactgg atttcagccc agtacaaacc     2040

tcccagggtg cctctgaccc cttgcctgac cccctggggc tgatggatct cagcaccact     2100

cccttgcaaa gtgctccccc ccttgaatca ccgcaaaggc tcctcagttc agaaccctta     2160

gacctcatct ccgtcccctt tggcaactct tctccctcag atatagacgt ccccaagcca     2220

ggctccccgg agccacaggt ttctggcctt gcagccaatc gttctctgac agaaggcctg     2280

gtcctggaca caatgaatga cagcctcagc aagatcctgc tggacatcag ctttcctggc     2340

ctggacgagg acccactggg ccctgacaac atcaactggt cccagtttat tcctgagcta     2400

cag                                                                   2403


<210>  82
<211>  1659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, FOXC1

<400>  82
atgcaggcgc gctactccgt gtccagcccc aactccctgg gagtggtgcc ctacctcggc       60

ggcgagcaga gctactaccg cgcggcggcc gcggcggccg ggggcggcta caccgccatg      120

ccggccccca tgagcgtgta ctcgcaccct gcgcacgccg agcagtaccc gggcggcatg      180

gcccgcgcct acgggcccta cacgccgcag ccgcagccca aggacatggt gaagccgccc      240

tatagctaca tcgcgctcat caccatggcc atccagaacg ccccggacaa gaagatcacc      300

ctgaacggca tctaccagtt catcatggac cgcttcccct tctaccggga caacaagcag      360

ggctggcaga acagcatccg ccacaacctc tcgctcaacg agtgcttcgt caaggtgccg      420

cgcgacgaca agaagccggg caagggcagc tactggacgc tggacccgga ctcctacaac      480

atgttcgaga acggcagctt cctgcggcgg cggcggcgct tcaagaagaa ggacgcggtg      540

aaggacaagg aggagaagga caggctgcac ctcaaggagc cgcccccgcc cggccgccag      600

cccccgcccg cgccgccgga gcaggccgac ggcaacgcgc ccggtccgca gccgccgccc      660

gtgcgcatcc aggacatcaa gaccgagaac ggtacgtgcc cctcgccgcc ccagcccctg      720

tccccggccg ccgccctggg cagcggcagc gccgccgcgg tgcccaagat cgagagcccc      780

gacagcagca gcagcagcct gtccagcggg agcagccccc cgggcagcct gccgtcggcg      840

cggccgctca gcctggacgg tgcggattcc gcgccgccgc cgcccgcgcc ctccgccccg      900

ccgccgcacc atagccaggg cttcagcgtg gacaacatca tgacgtcgct gcgggggtcg      960

ccgcagagcg cggccgcgga gctcagctcc ggccttctgg cctcggcggc cgcgtcctcg     1020

cgcgcgggga tcgcaccccc gctggcgctc ggcgcctact cgcccggcca gagctccctc     1080

tacagctccc cctgcagcca gacctccagc gcgggcagct cgggcggcgg cggcggcggc     1140

gcgggggccg cggggggcgc gggcggcgcc gggacctacc actgcaacct gcaagccatg     1200

agcctgtacg cggccggcga gcgcgggggc cacttgcagg gcgcgcccgg gggcgcgggc     1260

ggctcggccg tggacgaccc cctgcccgac tactctctgc ctccggtcac cagcagcagc     1320

tcgtcgtccc tgagtcacgg cggcggcggc ggcggcggcg ggggaggcca ggaggccggc     1380

caccaccctg cggcccacca aggccgcctc acctcgtggt acctgaacca ggcgggcgga     1440

gacctgggcc acttggcgag cgcggcggcg gcggcggcgg ccgcaggcta cccgggccag     1500

cagcagaact tccactcggt gcgggagatg ttcgagtcac agaggatcgg cttgaacaac     1560

tctccagtga acgggaatag tagctgtcaa atggccttcc cttccagcca gtctctgtac     1620

cgcacgtccg gagctttcgt ctacgactgt agcaagttt                            1659


<210>  83
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, FOXC2

<400>  83
atgcaggcgc gctactccgt gtccgacccc aacgccctgg gagtggtgcc ctacctgagc       60

gagcagaatt actaccgggc tgcgggcagc tacggcggca tggccagccc catgggcgtc      120

tattccggcc acccggagca gtacagcgcg gggatgggcc gctcctacgc gccctaccac      180

caccaccagc ccgcggcgcc taaggacctg gtgaagccgc cctacagcta catcgcgctc      240

atcaccatgg ccatccagaa cgcgcccgag aagaagatca ccttgaacgg catctaccag      300

ttcatcatgg accgcttccc cttctaccgg gagaacaagc agggctggca gaacagcatc      360

cgccacaacc tctcgctcaa cgagtgcttc gtcaaggtgc cccgcgacga caagaagccc      420

ggcaagggca gttactggac cctggacccg gactcctaca acatgttcga gaacggcagc      480

ttcctgcggc gccggcggcg cttcaaaaag aaggacgtgt ccaaggagaa ggaggagcgg      540

gcccacctca aggagccgcc cccggcggcg tccaagggcg ccccggccac cccccaccta      600

gcggacgccc ccaaggaggc cgagaagaag gtggtgatca agagcgaggc ggcgtccccg      660

gcgctgccgg tcatcaccaa ggtggagacg ctgagccccg agagcgcgct gcagggcagc      720

ccgcgcagcg cggcctccac gcccgccggc tcccccgacg gctcgctgcc ggagcaccac      780

gccgcggcgc ccaacgggct gcctggcttc agcgtggaga acatcatgac cctgcgaacg      840

tcgccgccgg gcggagagct gagcccgggg gccggacgcg cgggcctggt ggtgccgccg      900

ctggcgctgc cctacgccgc cgcgccgccc gccgcctacg gccagccgtg cgctcagggc      960

ctggaggccg gggccgccgg gggctaccag tgcagcatgc gagcgatgag cctgtacacc     1020

ggggccgagc ggccggcgca catgtgcgtc ccgcccgccc tggacgaggc cctctcggac     1080

cacccgagcg gccccacgtc gcccctgagc gctctcaacc tcgccgccgg ccaggagggc     1140

gcgctcgccg ccacgggcca ccaccaccag caccacggcc accaccaccc gcaggcgccg     1200

ccgcccccgc cggctcccca gccccagccg acgccgcagc ccggggccgc cgcggcgcag     1260

gcggcctcct ggtatctcaa ccacagcggg gacctgaacc acctccccgg ccacacgttc     1320

gcggcccagc agcaaacttt ccccaacgtg cgggagatgt tcaactccca ccggctgggg     1380

attgagaact cgaccctcgg ggagtcccag gtgagtggca atgccagctg ccagctgccc     1440

tacagatcca cgccgcctct ctatcgccac gcagccccct actcctacga ctgcacgaaa     1500

tac                                                                   1503


<210>  84
<211>  606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, TWIST1

<400>  84
atgatgcagg acgtgtccag ctcgccagtc tcgccggccg acgacagcct gagcaacagc       60

gaggaagagc cagaccggca gcagccgccg agcggcaagc gcgggggacg caagcggcgc      120

agcagcaggc gcagcgcggg cggcggcgcg gggcccggcg gagccgcggg tgggggcgtc      180

ggaggcggcg acgagccggg cagcccggcc cagggcaagc gcggcaagaa gtctgcgggc      240

tgtggcggcg gcggcggcgc gggcggcggc ggcggcagca gcagcggcgg cgggagtccg      300

cagtcttacg aggagctgca gacgcagcgg gtcatggcca acgtgcggga gcgccagcgc      360

acccagtcgc tgaacgaggc gttcgccgcg ctgcggaaga tcatccccac gctgccctcg      420

gacaagctga gcaagattca gaccctcaag ctggcggcca ggtacatcga cttcctctac      480

caggtcctcc agagcgacga gctggactcc aagatggcaa gctgcagcta tgtggctcac      540

gagcggctca gctacgcctt ctcggtctgg aggatggagg gggcctggtc catgtccgcg      600

tcccac                                                                 606


<210>  85
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, HIF1A

<400>  85
atggagggcg ccggcggcgc gaacgacaag aaaaagataa gttctgaacg tcgaaaagaa       60

aagtctcgag atgcagccag atctcggcga agtaaagaat ctgaagtttt ttatgagctt      120

gctcatcagt tgccacttcc acataatgtg agttcgcatc ttgataaggc ctctgtgatg      180

aggcttacca tcagctattt gcgtgtgagg aaacttctgg atgctggtga tttggatatt      240

gaagatgaca tgaaagcaca gatgaattgc ttttatttga aagccttgga tggttttgtt      300

atggttctca cagatgatgg tgacatgatt tacatttctg ataatgtgaa caaatacatg      360

ggattaactc agtttgaact aactggacac agtgtgtttg attttactca tccatgtgac      420

catgaggaaa tgagagaaat gcttacacac agaaatggcc ttgtgaaaaa gggtaaagaa      480

caaaacacac agcgaagctt ttttctcaga atgaagtgta ccctaactag ccgaggaaga      540

actatgaaca taaagtctgc aacatggaag gtattgcact gcacaggcca cattcacgta      600

tatgatacca acagtaacca acctcagtgt gggtataaga aaccacctat gacctgcttg      660

gtgctgattt gtgaacccat tcctcaccca tcaaatattg aaattccttt agatagcaag      720

actttcctca gtcgacacag cctggatatg aaattttctt attgtgatga aagaattacc      780

gaattgatgg gatatgagcc agaagaactt ttaggccgct caatttatga atattatcat      840

gctttggact ctgatcatct gaccaaaact catcatgata tgtttactaa aggacaagtc      900

accacaggac agtacaggat gcttgccaaa agaggtggat atgtctgggt tgaaactcaa      960

gcaactgtca tatataacac caagaattct caaccacagt gcattgtatg tgtgaattac     1020

gttgtgagtg gtattattca gcacgacttg attttctccc ttcaacaaac agaatgtgtc     1080

cttaaaccgg ttgaatcttc agatatgaaa atgactcagc tattcaccaa agttgaatca     1140

gaagatacaa gtagcctctt tgacaaactt aagaaggaac ctgatgcttt aactttgctg     1200

gccccagccg ctggagacac aatcatatct ttagattttg gcagcaacga cacagaaact     1260

gatgaccagc aacttgagga agtaccatta tataatgatg taatgctccc ctcacccaac     1320

gaaaaattac agaatataaa tttggcaatg tctccattac ccaccgctga aacgccaaag     1380

ccacttcgaa gtagtgctga ccctgcactc aatcaagaag ttgcattaaa attagaacca     1440

aatccagagt cactggaact ttcttttacc atgccccaga ttcaggatca gacacctagt     1500

ccttccgatg gaagcactag acaaagttca cctgagccta atagtcccag tgaatattgt     1560

ttttatgtgg atagtgatat ggtcaatgaa ttcaagttgg aattggtaga aaaacttttt     1620

gctgaagaca cagaagcaaa gaacccattt tctactcagg acacagattt agacttggag     1680

atgttagctc cctatatccc aatggatgat gacttccagt tacgttcctt cgatcagttg     1740

tcaccattag aaagcagttc cgcaagccct gaaagcgcaa gtcctcaaag cacagttaca     1800

gtattccagc agactcaaat acaagaacct actgctaatg ccaccactac cactgccacc     1860

actgatgaat taaaaacagt gacaaaagac cgtatggaag acattaaaat attgattgca     1920

tctccatctc ctacccacat acataaagaa actactagtg ccacatcatc accatataga     1980

gatactcaaa gtcggacagc ctcaccaaac agagcaggaa aaggagtcat agaacagaca     2040

gaaaaatctc atccaagaag ccctaacgtg ttatctgtcg ctttgagtca aagaactaca     2100

gttcctgagg aagaactaaa tccaaagata ctagctttgc agaatgctca gagaaagcga     2160

aaaatggaac atgatggttc actttttcaa gcagtaggaa ttatt                     2205


<210>  86
<211>  3159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, SALL4

<400>  86
atgtcgaggc gcaagcaggc gaaaccccag cacatcaact cggaggagga ccagggcgag       60

cagcagccgc agcagcagac cccggagttt gcagatgcgg ccccagcggc gcccgcggcg      120

ggggagctgg gtgctccagt gaaccaccca gggaatgacg aggtggcgag tgaggatgaa      180

gccacagtaa agcggcttcg tcgggaggag acgcacgtct gtgagaaatg ctgtgcggag      240

ttcttcagca tctctgagtt cctggaacat aagaaaaatt gcactaaaaa tccacctgtc      300

ctcatcatga atgacagcga ggggcctgtg ccttcagaag acttctccgg agctgtactg      360

agccaccagc ccaccagtcc cggcagtaag gactgtcaca gggagaatgg cggcagctca      420

gaggacatga aggagaagcc ggatgcggag tctgtggtgt acctaaagac agagacagcc      480

ctgccaccca ccccccagga cataagctat ttagccaaag gcaaagtggc caacactaat      540

gtgaccttgc aggcactacg gggcaccaag gtggcggtga atcagcggag cgcggatgca      600

ctccctgccc ccgtgcctgg tgccaacagc atcccgtggg tcctcgagca gatcttgtgt      660

ctgcagcagc agcagctaca gcagatccag ctcaccgagc agatccgcat ccaggtgaac      720

atgtgggcct cccacgccct ccactcaagc ggggcagggg ccgacactct gaagaccttg      780

ggcagccaca tgtctcagca ggtttctgca gctgtggctt tgctcagcca gaaagctgga      840

agccaaggtc tgtctctgga tgccttgaaa caagccaagc tacctcacgc caacatccct      900

tctgccacca gctccctgtc cccagggctg gcacccttca ctctgaagcc ggatgggacc      960

cgggtgctcc cgaacgtcat gtcccgcctc ccgagcgctt tgcttcctca ggccccgggc     1020

tcggtgctct tccagagccc tttctccact gtggcgctag acacatccaa gaaagggaag     1080

gggaagccac cgaacatctc cgcggtggat gtcaaaccca aagacgaggc ggccctctac     1140

aagcacaagt gtaagtactg tagcaaggtt tttgggactg atagctcctt gcagatccac     1200

ctccgctccc acactggaga gagacccttc gtgtgctctg tctgtggtca tcgcttcacc     1260

accaagggca acctcaaggt gcactttcac cgacatcccc aggtgaaggc aaacccccag     1320

ctgtttgccg agttccagga caaagtggcg gccggcaatg gcatccccta tgcactctct     1380

gtacctgacc ccatagatga accgagtctt tctttagaca gcaaacctgt ccttgtaacc     1440

acctctgtag ggctacctca gaatctttct tcggggacta atcccaagga cctcacgggt     1500

ggctccttgc ccggtgacct gcagcctggg ccttctccag aaagtgaggg tggacccaca     1560

ctccctgggg tgggaccaaa ctataattcc ccaagggctg gtggcttcca agggagtggg     1620

acccctgagc cagggtcaga gaccctgaaa ttgcagcagt tggtggagaa cattgacaag     1680

gccaccactg atcccaacga atgtctcatt tgccaccgag tcttaagctg tcagagctcc     1740

ctcaagatgc attatcgcac ccacaccggg gagagaccgt tccagtgtaa gatctgtggc     1800

cgagcctttt ctaccaaagg taacctgaag acacaccttg gggttcaccg aaccaacaca     1860

tccattaaga cgcagcattc gtgccccatc tgccagaaga agttcactaa tgccgtgatg     1920

ctgcagcaac atattcggat gcacatgggc ggtcagattc ccaacacgcc cctgccagag     1980

aatccctgtg actttacggg ttctgagcca atgaccgtgg gtgagaacgg cagcaccggc     2040

gctatctgcc atgatgatgt catcgaaagc atcgatgtag aggaagtcag ctcccaggag     2100

gctcccagca gctcctccaa ggtccccacg cctcttccca gcatccactc ggcatcaccc     2160

acgctagggt ttgccatgat ggcttcctta gatgccccag ggaaagtggg tcctgcccct     2220

tttaacctgc agcgccaggg cagcagagaa aacggttccg tggagagcga tggcttgacc     2280

aacgactcat cctcgctgat gggagaccag gagtatcaga gccgaagccc agatatcctg     2340

gaaaccacat ccttccaggc actctccccg gccaatagtc aagccgaaag catcaagtca     2400

aagtctcccg atgctgggag caaagcagag agctccgaga acagccgcac tgagatggaa     2460

ggtcggagca gtctcccttc cacgtttatc cgagccccgc cgacctatgt caaggttgaa     2520

gttcctggca catttgtggg accctcgaca ttgtccccag ggatgacccc tttgttagca     2580

gcccagccac gccgacaggc caagcaacat ggctgcacac ggtgtgggaa gaacttctcg     2640

tctgctagcg ctcttcagat ccacgagcgg actcacactg gagagaagcc ttttgtgtgc     2700

aacatttgtg ggcgagcttt taccaccaaa ggcaacttaa aggttcacta catgacacac     2760

ggggcgaaca ataactcagc ccgccgtgga aggaagttgg ccatcgagaa caccatggct     2820

ctgttaggta cggacggaaa aagagtctca gaaatctttc ccaaggaaat cctggcccct     2880

tcagtgaatg tggaccctgt tgtgtggaac cagtacacca gcatgctcaa tggcggtctg     2940

gccgtgaaga ccaatgagat ctctgtgatc cagagtgggg gggttcctac cctcccggtt     3000

tccttggggg ccacctccgt tgtgaataac gccactgtct ccaagatgga tggctcccag     3060

tcgggtatca gtgcagatgt ggaaaaacca agtgctactg acggcgttcc caaacaccag     3120

tttcctcact tcctggaaga aaacaagatt gcggtcagc                            3159


<210>  87
<211>  1857
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, ELF1

<400>  87
atggctgctg ttgtccaaca gaacgaccta gtatttgaat ttgctagtaa cgtcatggag       60

gatgaacgac agcttggtga tccagctatt tttcctgccg taattgtgga acatgttcct      120

ggtgctgata ttctcaatag ttatgccggt ctagcctgtg tggaagagcc caatgacatg      180

attactgaga gttcactgga tgttgctgaa gaagaaatca tagacgatga tgatgatgac      240

atcaccctta cagttgaagc ttcttgtcat gacggggatg aaacaattga aactattgag      300

gctgctgagg cactcctcaa tatggattcc cctggcccta tgctggatga aaaacgaata      360

aataataata tatttagttc acctgaagat gacatggttg ttgccccagt cacccatgtg      420

tccgtcacat tagatgggat tcctgaagtg atggaaacac agcaggtgca agaaaaatat      480

gcagactcac cgggagcctc atcaccagaa cagcctaaga ggaaaaaagg aagaaaaact      540

aaaccaccac gaccagattc cccagccact acgccaaata tatctgtgaa gaagaaaaac      600

aaagatggaa agggaaacac aatttatctt tgggagtttt tactggcact gctccaggac      660

aaggctactt gtcctaaata catcaagtgg acccagcgag agaaaggcat ttttaaattg      720

gtggattcta aagcagtgtc caggttgtgg gggaagcaca aaaacaaacc tgatatgaat      780

tatgagacca tgggaagagc actcaggtac tattaccaaa ggggtattct ggcaaaagtg      840

gaaggtcagc gcttggtgta tcagtttaaa gaaatgccaa aagatcttat atatataaat      900

gatgaggatc caagttccag catagagtct tcagatccat cgctatcttc atcagccact      960

tcaaatagga atcaaaccag ccggtcgaga gtatcttcaa gtccaggggt aaaaggagga     1020

gccactacag ttctaaaacc agggaattct aaagctgcaa aacccaaaga tcctgtggaa     1080

gttgcacaac catcagaagt tttgaggaca gtgcagccca cgcagtctcc atatcctacc     1140

cagctcttcc ggactgttca tgtagtacag ccagtacagg ctgtcccaga gggagaagca     1200

gctagaacca gtaccatgca ggatgaaaca ttaaattctt ccgttcagag tattaggact     1260

atacaggctc caacccaagt tccagtggtt gtgtctccta ggaatcagca gttgcataca     1320

gtaacactcc aaacagtgcc actcacaaca gttatagcca gcacagatcc atcagcaggt     1380

actggatctc agaagtttat tttacaagcc attccatcat cacagcccat gacagtactg     1440

aaagaaaatg tcatgctgca gtcacaaaag gcgggctctc ctccttcaat tgtcttgggc     1500

cctgcccagg ttcagcaggt ccttactagc aatgttcaga ccatttgcaa tggaaccgtc     1560

agtgtggctt cctctccatc cttcagtgct actgcacctg tggtgacctt ttctcctcgc     1620

agttcacagc tggttgctca cccacctggc actgtaatca cttcagttat caaaactcaa     1680

gaaacaaaaa ctcttacaca ggaagtagag aaaaaggaat ctgaagatca tttgaaagag     1740

aacactgaga aaacggagca gcagccacag ccttatgtga tggtagtgtc cagttccaat     1800

ggatttactt ctcaggtagc tatgaaacaa aacgaactgc tggaacccaa ctctttt        1857


<210>  88
<211>  1527
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, SOX9

<400>  88
atgaatctcc tggacccctt catgaagatg accgacgagc aggagaaggg cctgtccggc       60

gcccccagcc ccaccatgtc cgaggactcc gcgggctcgc cctgcccgtc gggctccggc      120

tcggacaccg agaacacgcg gccccaggag aacacgttcc ccaagggcga gcccgatctg      180

aagaaggaga gcgaggagga caagttcccc gtgtgcatcc gcgaggcggt cagccaggtg      240

ctcaaaggct acgactggac gctggtgccc atgccggtgc gcgtcaacgg ctccagcaag      300

aacaagccgc acgtcaagcg gcccatgaac gccttcatgg tgtgggcgca ggcggcgcgc      360

aggaagctcg cggaccagta cccgcacttg cacaacgccg agctcagcaa gacgctgggc      420

aagctctgga gacttctgaa cgagagcgag aagcggccct tcgtggagga ggcggagcgg      480

ctgcgcgtgc agcacaagaa ggaccacccg gattacaagt accagccgcg gcggaggaag      540

tcggtgaaga acgggcaggc ggaggcagag gaggccacgg agcagacgca catctccccc      600

aacgccatct tcaaggcgct gcaggccgac tcgccacact cctcctccgg catgagcgag      660

gtgcactccc ccggcgagca ctcggggcaa tcccagggcc caccgacccc acccaccacc      720

cccaaaaccg acgtgcagcc gggcaaggct gacctgaagc gagaggggcg ccccttgcca      780

gaggggggca gacagccccc tatcgacttc cgcgacgtgg acatcggcga gctgagcagc      840

gacgtcatct ccaacatcga gaccttcgat gtcaacgagt ttgaccagta cctgccgccc      900

aacggccacc cgggggtgcc ggccacgcac ggccaggtca cctacacggg cagctacggc      960

atcagcagca ccgcggccac cccggcgagc gcgggccacg tgtggatgtc caagcagcag     1020

gcgccgccgc cacccccgca gcagccccca caggccccgc cggccccgca ggcgcccccg     1080

cagccgcagg cggcgccccc acagcagccg gcggcacccc cgcagcagcc acaggcgcac     1140

acgctgacca cgctgagcag cgagccgggc cagtcccagc gaacgcacat caagacggag     1200

cagctgagcc ccagccacta cagcgagcag cagcagcact cgccccaaca gatcgcctac     1260

agccccttca acctcccaca ctacagcccc tcctacccgc ccatcacccg ctcacagtac     1320

gactacaccg accaccagaa ctccagctcc tactacagcc acgcggcagg ccagggcacc     1380

ggcctctact ccaccttcac ctacatgaac cccgctcagc gccccatgta cacccccatc     1440

gccgacacct ctggggtccc ttccatcccg cagacccaca gcccccagca ctgggaacaa     1500

cccgtctaca cacagctcac tcgacct                                         1527


<210>  89
<211>  945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, SOX12

<400>  89
atggtgcagc agcggggcgc gagggccaag cgggacggcg ggccgccgcc cccgggaccc       60

gggccggccg aggagggggc gcgcgagccc ggctggtgca agaccccgag cggccacatc      120

aagaggccga tgaacgcatt catggtgtgg tcgcagcacg aacggcggaa gatcatggac      180

cagtggcccg acatgcacaa cgccgagatc tccaagcgcc tgggccgccg ctggcagctg      240

ctgcaggact cggagaagat cccgttcgtg cgggaggcgg agcggctgcg gctcaagcac      300

atggcggatt acccggacta caagtaccgg ccgcgcaaaa agagcaaggg ggcgcccgcc      360

aaggcgcggc cccgcccccc cggtggtagc ggtggcggca gccggctcaa gcccgggccg      420

cagctgcctg gccgcggggg ccgccgagca gcgggagggc ctttgggggg cggggcggcg      480

gcgcccgagg acgacgatga agacgacgac gaggagctgc tggaagtgcg cctggtcgag      540

accccggggc gggagctgtg gaggatggtc ccggcgggac gggccgctcg gggacaagcg      600

gagcgcgccc aagggccgtc gggcgagggg gcggccgccg ccgccgccgc ctccccgaca      660

ccgtcggagg acgaggagcc ggaggaagag gaggaggagg cggcagcggc tgaggaaggt      720

gaagaggaga cggtggcgtc gggggaggag tcgctgggct ttctgtccag gctgccccct      780

ggcccggccg gcctggactg cagcgccctg gatcgcgacc cggacctgca gcctccctcg      840

ggcacgtcgc acttcgagtt cccggactac tgcacccccg aggttaccga gatgatcgcg      900

ggggactggc gcccgtctag catcgcagac ctggttttca cctac                      945


<210>  90
<211>  1152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, SOX18

<400>  90
atgcagagat cgccgcccgg ctacggcgca caggacgacc cgcccgcccg ccgcgactgt       60

gcatgggccc cgggacacgg ggccgccgct gacacgcgcg gcctcgccgc cggccccgcc      120

gccctcgccg cgcccgccgc gcccgcctcg ccgcccagcc cgcagcgcag tcccccgcgc      180

agccccgagc cggggcgcta tggcctcagc ccggccggcc gcggggaacg ccaggcggca      240

gacgagtcgc gcatccggcg gcccatgaac gccttcatgg tgtgggcaaa ggacgagcgc      300

aagcggctgg ctcagcagaa cccggacctg cacaacgcgg tgctcagcaa gatgctgggc      360

aaagcgtgga aggagctgaa cgcggcggag aagcggccct tcgtggagga agccgaacgg      420

ctgcgcgtgc agcacttgcg cgaccacccc aactacaagt accggccgcg ccgcaagaag      480

caggcgcgca aggcccggcg gctggagccc ggcctcctgc tcccgggatt agcgcccccg      540

cagccaccgc ccgagccttt ccccgcggcg tctggctcgg ctcgcgcctt ccgcgagctg      600

cccccgctgg gcgccgagtt cgacggcctg gggctgccca cgcccgagcg ctcgcctctg      660

gacggcctgg agcccggcga ggctgccttc ttcccaccgc ccgcggcgcc cgaggactgc      720

gcgctgcggc ccttccgcgc gccctacgcg cccaccgagt tgtcgcggga ccccggcggt      780

tgctacgggg ctcccctggc ggaggcgctc aggaccgcgc cccccgcggc gccgctcgct      840

ggcctgtact acggcaccct gggcacgccc ggcccgtacc ccggcccgct gtcgccgccg      900

cccgaggccc cgccgctgga gagcgccgag ccgctggggc ccgccgccga tctgtgggcc      960

gacgtggacc tcaccgagtt cgaccagtac ctcaactgca gccggactcg gcccgacgcc     1020

cccgggctcc cgtaccacgt ggcactggcc aaactgggcc cgcgcgccat gtcctgccca     1080

gaggagagca gcctgatctc cgcgctgtcg gacgccagca gcgcggtcta ttacagcgcg     1140

tgcatctccg gc                                                         1152


<210>  91
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, ETS1

<400>  91
atgaaggcgg ccgtcgatct caagccgact ctcaccatca tcaagacgga aaaagtcgat       60

ctggagcttt tcccctcccc ggatatggaa tgtgcagatg tcccactatt aactccaagc      120

agcaaagaaa tgatgtctca agcattaaaa gctactttca gtggtttcac taaagaacag      180

caacgactgg ggatcccaaa agacccccgg cagtggacag aaacccatgt tcgggactgg      240

gtgatgtggg ctgtgaatga attcagcctg aaaggtgtag acttccagaa gttctgtatg      300

aatggagcag ccctctgcgc cctgggtaaa gactgctttc tcgagctggc cccagacttt      360

gttggggaca tcttatggga acatctagag atcctgcaga aagaggatgt gaaaccatat      420

caagttaatg gagtcaaccc agcctatcca gaatcccgct atacctcgga ttacttcatt      480

agctatggta ttgagcatgc ccagtgtgtt ccaccatcgg agttctcaga gcccagcttc      540

atcacagagt cctatcagac gctccatccc atcagctcgg aagagctcct ctccctcaag      600

tatgagaatg actacccctc ggtcattctc cgagaccctc tccagacaga caccttgcag      660

aatgactact ttgctatcaa acaagaagtc gtcaccccag acaacatgtg catggggagg      720

accagtcgtg gtaaactcgg gggccaggac tcttttgaaa gcatagagag ctacgatagt      780

tgtgatcgcc tcacccagtc ctggagcagc cagtcatctt tcaacagcct gcagcgtgtt      840

ccctcctatg acagcttcga ctcagaggac tatccggctg ccctgcccaa ccacaagccc      900

aagggcacct tcaaggacta tgtgcgggac cgtgctgacc tcaataagga caagcctgtc      960

attcctgctg ctgccctagc tggctacaca ggcagtggac caatccagct atggcagttt     1020

cttctggaat tactcactga taaatcctgt cagtctttta tcagctggac aggagatggc     1080

tgggaattca aactttctga cccagatgag gtggccagga gatggggaaa gaggaaaaac     1140

aaacctaaga tgaattatga gaaactgagc cgtggcctac gctactatta cgacaaaaac     1200

atcatccaca agacagcggg gaaacgctac gtgtaccgct ttgtgtgtga cctgcagagc     1260

ctgctggggt acacccctga ggagctgcac gccatgctgg acgtcaagcc agatgccgac     1320

gag                                                                   1323


<210>  92
<211>  618
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, PAX3

<400>  92
atgaccacgc tggccggcgc tgtgcccagg atgatgcggc cgggcccggg gcagaactac       60

ccgcgtagcg ggttcccgct ggaagtgtcc actcccctcg gccagggccg cgtcaaccag      120

ctcggcggtg tttttatcaa cggcaggccg ctgcccaacc acatccgcca caagatcgtg      180

gagatggccc accacggcat ccggccctgc gtcatctcgc gccagctgcg cgtgtcccac      240

ggctgcgtct ccaagatcct gtgcaggtac caggagactg gctccatacg tcctggtgcc      300

atcggcggca gcaagcccaa gcaggtgaca acgcctgacg tggagaagaa aattgaggaa      360

tacaaaagag agaacccggg catgttcagc tgggaaatcc gagacaaatt actcaaggac      420

gcggtctgtg atcgaaacac cgtgccgtca gtgagttcca tcagccgcat cctgagaagt      480

aaattcggga aaggtgaaga ggaggaggcc gacttggaga ggaaggaggc agaggaaagc      540

gagaagaagg ccaaacacag catcgacggc atcctgagcg agcgaggaaa ggccctggtc      600

tccggagttt cctcgcat                                                    618


<210>  93
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, PAX8

<400>  93
atgcctcaca actccatcag atctggccat ggagggctga accagctggg aggggccttt       60

gtgaatggca gacctctgcc ggaagtggtc cgccagcgca tcgtagacct ggcccaccag      120

ggtgtaaggc cctgcgacat ctctcgccag ctccgcgtca gccatggctg cgtcagcaag      180

atccttggca ggtactacga gactggcagc atccggcctg gagtgatagg gggctccaag      240

cccaaggtgg ccacccccaa ggtggtggag aagattgggg actacaaacg ccagaaccct      300

accatgtttg cctgggagat ccgagaccgg ctcctggctg agggcgtctg tgacaatgac      360

actgtgccca gtgtcagctc cattaataga atcatccgga ccaaagtgca gcaaccattc      420

aacctcccta tggacagctg cgtggccacc aagtccctga gtcccggaca cacgctgatc      480

cccagctcag ctgtaactcc cccggagtca ccccagtcgg attccctggg ctccacctac      540

tccatcaatg ggctcctggg catcgctcag cctggcagcg acaagaggaa aatggatgac      600

agtgatcagg atagctgccg actaagcatt gactcacaga gcagcagcag cggaccccga      660

aagcaccttc gcacggatgc cttcagccag caccacctcg agccgctcga gtgcccattt      720

gagcggcagc actacccaga ggcctatgcc tcccccagcc acaccaaagg cgagcagggc      780

ctctacccgc tgcccttgct caacagcacc ctggacgacg ggaaggccac cctgacccct      840

tccaacacgc cactggggcg caacctctcg actcaccaga cctaccccgt ggtggcagat      900

cctcactcac ccttcgccat aaagcaggaa acccccgagg tgtccagttc tagctccacc      960

ccttcctctt tatctagctc cgcctttttg gatctgcagc aagtcggctc cggggtcccg     1020

cccttcaatg cctttcccca tgctgcctcc gtgtacgggc agttcacggg ccaggccctc     1080

ctctcagggc gagagatggt ggggcccacg ctgcccggat acccacccca catccccacc     1140

agcggacagg gcagctatgc ctcctctgcc atcgcaggca tggtggcagg aagtgaatac     1200

tctggcaatg cctatggcca caccccctac tcctcctaca gcgaggcctg gcgcttcccc     1260

aactccagct tgctgagttc cccatattat tacagttcca catcaaggcc gagtgcaccg     1320

cccaccactg ccacggcctt tgaccatctg                                      1350


<210>  94
<211>  3321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, GLI1

<400>  94
atgttcaact cgatgacccc accaccaatc agtagctatg gcgagccctg ctgtctccgg       60

cccctcccca gtcagggggc ccccagtgtg gggacagaag gactgtctgg cccgcccttc      120

tgccaccaag ctaacctcat gtccggcccc cacagttatg ggccagccag agagaccaac      180

agctgcaccg agggcccact cttttcttct ccccggagtg cagtcaagtt gaccaagaag      240

cgggcactgt ccatctcacc tctgtcggat gccagcctgg acctgcagac ggttatccgc      300

acctcaccca gctccctcgt agctttcatc aactcgcgat gcacatctcc aggaggctcc      360

tacggtcatc tctccattgg caccatgagc ccatctctgg gattcccagc ccagatgaat      420

caccaaaaag ggccctcgcc ttcctttggg gtccagcctt gtggtcccca tgactctgcc      480

cggggtggga tgatcccaca tcctcagtcc cggggaccct tcccaacttg ccagctgaag      540

tctgagctgg acatgctggt tggcaagtgc cgggaggaac ccttggaagg tgatatgtcc      600

agccccaact ccacaggcat acaggatccc ctgttgggga tgctggatgg gcgggaggac      660

ctcgagagag aggagaagcg tgagcctgaa tctgtgtatg aaactgactg ccgttgggat      720

ggctgcagcc aggaatttga ctcccaagag cagctggtgc accacatcaa cagcgagcac      780

atccacgggg agcggaagga gttcgtgtgc cactgggggg gctgctccag ggagctgagg      840

cccttcaaag cccagtacat gctggtggtt cacatgcgca gacacactgg cgagaagcca      900

cacaagtgca cgtttgaagg gtgccggaag tcatactcac gcctcgaaaa cctgaagacg      960

cacctgcggt cacacacggg tgagaagcca tacatgtgtg agcacgaggg ctgcagtaaa     1020

gccttcagca atgccagtga ccgagccaag caccagaatc ggacccattc caatgagaag     1080

ccgtatgtat gtaagctccc tggctgcacc aaacgctata cagatcctag ctcgctgcga     1140

aaacatgtca agacagtgca tggtcctgac gcccatgtga ccaaacggca ccgtggggat     1200

ggccccctgc ctcgggcacc atccatttct acagtggagc ccaagaggga gcgggaagga     1260

ggtcccatca gggaggaaag cagactgact gtgccagagg gtgccatgaa gccacagcca     1320

agccctgggg cccagtcatc ctgcagcagt gaccactccc cggcagggag tgcagccaat     1380

acagacagtg gtgtggaaat gactggcaat gcagggggca gcactgaaga cctctccagc     1440

ttggacgagg gaccttgcat tgctggcact ggtctgtcca ctcttcgccg ccttgagaac     1500

ctcaggctgg accagctaca tcaactccgg ccaataggga cccggggtct caaactgccc     1560

agcttgtccc acaccggtac cactgtgtcc cgccgcgtgg gccccccagt ctctcttgaa     1620

cgccgcagca gcagctccag cagcatcagc tctgcctata ctgtcagccg ccgctcctcc     1680

ctggcctctc ctttcccccc tggctcccca ccagagaatg gagcatcctc cctgcctggc     1740

cttatgcctg cccagcacta cctgcttcgg gcaagatatg cttcagccag agggggtggt     1800

acttcgccca ctgcagcatc cagcctggat cggataggtg gtcttcccat gcctccttgg     1860

agaagccgag ccgagtatcc aggatacaac cccaatgcag gggtcacccg gagggccagt     1920

gacccagccc aggctgctga ccgtcctgct ccagctagag tccagaggtt caagagcctg     1980

ggctgtgtcc ataccccacc cactgtggca gggggaggac agaactttga tccttacctc     2040

ccaacctctg tctactcacc acagcccccc agcatcactg agaatgctgc catggatgct     2100

agagggctac aggaagagcc agaagttggg acctccatgg tgggcagtgg tctgaacccc     2160

tatatggact tcccacctac tgatactctg ggatatgggg gacctgaagg ggcagcagct     2220

gagccttatg gagcgagggg tccaggctct ctgcctcttg ggcctggtcc acccaccaac     2280

tatggcccca acccctgtcc ccagcaggcc tcatatcctg accccaccca agaaacatgg     2340

ggtgagttcc cttcccactc tgggctgtac ccaggcccca aggctctagg tggaacctac     2400

agccagtgtc ctcgacttga acattatgga caagtgcaag tcaagccaga acaggggtgc     2460

ccagtggggt ctgactccac aggactggca ccctgcctca atgcccaccc cagtgagggg     2520

cccccacatc cacagcctct cttttcccat tacccccagc cctctcctcc ccaatatctc     2580

cagtcaggcc cctataccca gccaccccct gattatcttc cttcagaacc caggccttgc     2640

ctggactttg attcccccac ccattccaca gggcagctca aggctcagct tgtgtgtaat     2700

tatgttcaat ctcaacagga gctactgtgg gagggtgggg gcagggaaga tgcccccgcc     2760

caggaacctt cctaccagag tcccaagttt ctggggggtt cccaggttag cccaagccgt     2820

gctaaagctc cagtgaacac atatggacct ggctttggac ccaacttgcc caatcacaag     2880

tcaggttcct atcccacccc ttcaccatgc catgaaaatt ttgtagtggg ggcaaatagg     2940

gcttcacata gggcagcagc accacctcga cttctgcccc cattgcccac ttgctatggg     3000

cctctcaaag tgggaggcac aaaccccagc tgtggtcatc ctgaggtggg caggctagga     3060

gggggtcctg ccttgtaccc tcctcccgaa ggacaggtat gtaaccccct ggactctctt     3120

gatcttgaca acactcagct ggactttgtg gctattctgg atgagcccca ggggctgagt     3180

cctcctcctt cccatgatca gcggggcagc tctggacata ccccacctcc ctctgggccc     3240

cccaacatgg ctgtgggcaa catgagtgtc ttactgagat ccctacctgg ggaaacagaa     3300

ttcctcaact ctagtgccta a                                               3321


<210>  95
<211>  4758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, GLI2

<400>  95
atggagacgt ctgcctcagc cactgcctcc gagaagcaag aagccaaaag tgggatcctg       60

gaggccgctg gcttccccga cccgggtaaa aaggcctctc ctttggtggt ggctgcagcg      120

gcagcagcag cggtagctgc ccaaggagtg ccgcagcatc tcttgccacc attccatgcg      180

cccctaccga ttgacatgcg acaccaggaa ggaaggtacc attacgagcc tcattctgtc      240

cacggtgtgc acgggccccc tgccctcagc ggcagccctg tcatctctga catctccttg      300

atccggcttt ccccgcaccc ggctggccct ggggagtccc ccttcaacgc cccccacccg      360

tacgtgaacc cccacatgga gcactacctc cgttctgtgc acagcagccc cacgctctcc      420

atgatctctg cagccagggg cctcagcccc gctgatgtgg cccaggagca ccttaaggag      480

aggggactgt ttggccttcc tgctccaggc accaccccct cagactatta ccaccagatg      540

accctcgtgg caggccaccc cgcgccctac ggggacctgc tgatgcagag cgggggcgct      600

gccagcgcac cccatctcca cgactacctc aaccccgtgg acgtgtcccg tttctccagc      660

ccgcgggtga cgccccgcct gagccgcaag cgggcgctgt ccatctcccc actctcagac      720

gccagcctgg acctgcagcg gatgatccgc acctcaccca actcgctagt ggcctacatc      780

aacaactccc gaagcagctc ggcggccagc ggttcctacg ggcatctgtc agcgggtgcc      840

ctcagcccag ccttcacctt cccccacccc atcaaccccg tggcctacca gcagattctg      900

agccagcaga ggggtctggg gtcagccttt ggacacacac cacccctgat ccagccctca      960

cccaccttcc tggcccagca gcccatggcc ctcacctcca tcaatgccac gcccacccag     1020

ctcagcagca gcagcaactg tctgagtgac accaaccaga acaagcagag cagtgagtcg     1080

gccgtcagca gcaccgtcaa ccctgtcgcc attcacaagc gcagcaaggt caagaccgag     1140

cctgagggcc tgcggccggc ctcccctctg gcgctgacgc agggccaggt gtctggacac     1200

ggctcatgtg ggtgtgccct tcccctctcc caggagcagc tggctgacct caaggaagat     1260

ctggacaggg atgactgtaa gcaggaggct gaggtggtca tctatgagac caactgccac     1320

tgggaagact gcaccaagga gtacgacacc caggagcagc tggtgcatca catcaacaac     1380

gagcacatcc acggggagaa gaaggagttt gtgtgccgct ggcaggcctg cacgcgggag     1440

cagaagccct tcaaggcgca gtacatgctg gtggtgcaca tgcggcgaca cacgggcgag     1500

aagccccaca agtgcacgtt cgagggctgc tcgaaggcct actcccgcct ggagaacctg     1560

aagacacacc tgcggtccca caccggggag aagccatatg tgtgtgagca cgagggctgc     1620

aacaaagcct tctccaacgc ctcggaccgc gccaagcacc agaatcgcac ccactccaac     1680

gagaaaccct acatctgcaa gatcccaggc tgcaccaaga gatacacaga ccccagctct     1740

ctccggaagc atgtgaaaac ggtccacggc ccagatgccc acgtcaccaa gaagcagcgc     1800

aatgacgtgc acctccgcac accgctgctc aaagagaatg gggacagtga ggccggcacg     1860

gagcctggcg gcccagagag caccgaggcc agcagcacca gccaggccgt ggaggactgc     1920

ctgcacgtca gagccatcaa gaccgagagc tccgggctgt gtcagtccag ccccggggcc     1980

cagtcgtcct gcagcagcga gccctctcct ctgggcagtg cccccaacaa tgacagtggc     2040

gtggagatgc cggggacggg gcccgggagc ctgggagacc tgacggcact ggatgacaca     2100

cccccagggg ccgacacctc agccctggct gccccctccg ctggtggcct ccagctgcgc     2160

aaacacatga ccaccatgca ccggttcgag cagctcaaga aggagaagct caagtcactc     2220

aaggattcct gctcatgggc cgggccgact ccacacacgc ggaacaccaa gctgcctccc     2280

ctcccgggaa gtggctccat cctggaaaac ttcagtggca gtgggggcgg cgggcccgcg     2340

gggctgctgc cgaacccgcg gctgtcggag ctgtccgcga gcgaggtgac catgctgagc     2400

cagctgcagg agcgccgcga cagctccacc agcacggtca gctcggccta caccgtgagc     2460

cgccgctcct ccggcatctc cccctacttc tccagccgcc gctccagcga ggcctcgccc     2520

ctgggcgccg gccgcccgca caacgcgagc tccgctgact cctacgaccc catctccacg     2580

gacgcgtcgc ggcgctcgag cgaggccagc cagtgcagcg gcggctccgg gctgctcaac     2640

ctcacgccgg cgcagcagta cagcctgcgg gccaagtacg cggcagccac tggcggcccc     2700

ccgcccactc cgctgccggg cctggagcgc atgagcctgc ggaccaggct ggcgctgctg     2760

gacgcgcccg agcgcacgct gcccgccggc tgcccacgcc cactggggcc gcggcgtggc     2820

agcgacgggc cgacctatgg ccacggccac gcgggggctg cgcccgcctt cccccacgag     2880

gctccaggcg gcggagccag gcgggccagc gaccctgtgc ggcggcccga tgccctgtcc     2940

ctgccgcggg tgcagcgctt ccacagcacc cacaacgtga accccggccc gctgccgccc     3000

tgtgccgaca ggcgaggcct ccgcctgcag agccacccga gcaccgacgg cggcctggcc     3060

cgcggcgcct actcgccccg gccgcctagc atcagcgaga acgtggcgat ggaggccgtg     3120

gcggcaggag tggacggcgc ggggcccgag gccgacctgg ggctgccgga ggacgacctg     3180

gtgcttccag acgacgtggt gcagtacatc aaggcgcacg ccagtggcgc tctggacgag     3240

ggcaccgggc aggtgtatcc cacggaaagc actggcttct ctgacaaccc cagactaccc     3300

agcccggggc tgcacggcca gcgcaggatg gtggctgcgg actccaacgt gggcccctcc     3360

gcccctatgc tgggaggatg ccagttaggc tttggggcgc cctccagcct gaacaaaaat     3420

aacatgcctg tgcagtggaa tgaggtgagc tccggcaccg tagacgccct ggccagccag     3480

gtgaagcctc caccctttcc tcagggcaac ctggcggtgg tgcagcagaa gcctgccttt     3540

ggccagtacc cgggctacag tccgcaaggc ctacaggcta gccctggggg cctggacagc     3600

acgcagccac acctgcagcc ccgcagcgga gccccctccc agggcatccc cagggtaaac     3660

tacatgcagc agctgcgaca gccagtggca ggcagccagt gtcctggcat gactaccact     3720

atgagccccc atgcctgcta tggccaagtc cacccccagc tgagccccag caccatcagt     3780

ggggccctca accagttccc ccaatcctgc agcaacatgc cagccaagcc agggcatctg     3840

gggcaccctc agcagacaga agtggcacct gaccccacca cgatgggcaa tcgccacagg     3900

gaacttgggg tccccgattc agccctggct ggagtgccac cacctcaccc agtccagagc     3960

tacccacagc agagccatca cctggcagcc tccatgagcc aggagggcta ccaccaggtc     4020

cccagccttc tgcctgcccg ccagcctggc ttcatggagc cccaaacagg cccgatgggg     4080

gtggctacag caggctttgg cctagtgcag ccccggcctc ccctcgagcc cagccccact     4140

ggccgccacc gtggggtacg tgctgtgcag cagcagctgg cctacgccag ggccacaggc     4200

catgccatgg ctgccatgcc gtccagtcag gaaacagcag aggctgtgcc caagggagcg     4260

atgggcaaca tggggtcggt gcctccccag ccgcctccgc aggacgcagg tggggccccg     4320

gaccacagca tgctctacta ctacggccag atccacatgt acgaacagga tggaggcctg     4380

gagaacctcg ggagctgcca ggtcatgcgg tcccagccac cacagccaca ggcctgtcag     4440

gacagcatcc agccccagcc cttgccctca ccaggggtca accaggtgtc cagcactgtg     4500

gactcccagc tcctggaggc cccccagatt gacttcgatg ccatcatgga tgatggcgat     4560

cactcgagtt tgttctcggg tgctctgagc cccagcctcc tccacagcct ctcccagaac     4620

tcctcccgcc tcaccacccc ccgaaactcc ttgaccctgc cctccatccc cgcaggcatc     4680

agcaacatgg ctgtcgggga catgagctcc atgctcacca gcctcgccga ggagagcaag     4740

ttcctgaaca tgatgacc                                                   4758


<210>  96
<211>  4740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, GLI3

<400>  96
atggaggccc agtcccacag ctccacgacc actgaaaaga aaaaagttga gaattccata       60

gtgaagtgct ccactcgaac agatgtgagc gagaaagccg ttgcctccag caccacttct      120

aatgaggatg aaagtcctgg acagacttat cacagagaga gaagaaacgc aatcactatg      180

cagccacaga atgtccaggg gctcagcaaa gtcagtgagg aaccttcaac atcgagtgac      240

gagagggcct cattgatcaa gaaagagatc catgggtccc tgccacacgt ggcggagccc      300

tctgtgccgt accgcgggac ggtgtttgcc atggacccca ggaatggtta catggagccc      360

cactaccacc ctcctcatct tttccctgcc ttccatcctc ctgtaccaat tgatgccaga      420

catcatgagg gccgttacca ttacgatcca tctccgattc ctccattgca tatgacttcc      480

gccttatcta gtagccctac gtatccggac ctgcccttca ttaggatctc cccacaccgg      540

aaccccactg ctgcttccga gtctcccttc agccctccac atccctacat taatccctac      600

atggactata tccgctcctt gcacagcagc ccatcgctct ccatgatctc agcaacccgt      660

gggctgagcc ctacagatgc gccccatgca ggagtcagcc cagcagaata ctatcatcag      720

atggccctgc taactggcca gcgcagcccc tatgcagaca ttattccctc agctgccacc      780

gccggcacgg gggccatcca catggaatat cttcatgcta tggatagcac cagattctcc      840

agccccaggc tgtcagccag gccgagccga aaacgtacac tgtccatatc accactctcc      900

gatcatagct ttgaccttca gaccatgata aggacgtctc ccaactcctt ggtcacgatt      960

ctcaataatt cccgtagcag ctcttcagca agtggctcct atggtcactt atctgcaagt     1020

gcaatcagcc ctgccttgag cttcacctac tcttccgcgc ccgtctctct ccacatgcat     1080

cagcagatcc taagccgaca acagagctta ggttcagcct ttggacacag ccctccactc     1140

atccaccctg ccccaacttt tccaacacag aggcctattc cagggatccc tacggttctg     1200

aaccccgtcc aggtcagctc cggcccttct gagtcctcac agaacaagcc cacgagtgag     1260

tctgcagtga gcagcactgg tgacccgatg cacaacaaga ggtccaagat caaacccgat     1320

gaagacctcc ccagcccagg ggctcggggg cagcaggaac agcccgaagg aacaaccctt     1380

gtcaaggagg aaggggacaa agatgaaagc aaacaggagc ctgaagtcat ctatgagaca     1440

aactgccact gggaaggctg cgcgagggag ttcgacaccc aagagcagct tgtgcaccat     1500

ataaataacg accatattca tggagagaag aaggagttcg tgtgcaggtg gctggactgc     1560

tcaagagagc agaaaccctt caaagcccag tatatgttgg tagtgcatat gagaagacac     1620

acgggcgaga agcctcacaa atgcactttt gaaggttgca caaaggccta ctcgagacta     1680

gaaaacttga aaacacactt gagatctcac actggagaga aaccatacgt ctgtgagcac     1740

gaaggttgca acaaggcttt ctcaaatgcc tctgatcgcg ccaaacacca aaacagaacg     1800

cattccaatg agaaaccata tgtgtgcaaa atcccaggct gcactaagcg ttacacagac     1860

ccaagctccc tccggaaaca tgtgaagaca gtgcatggcc cagaggctca tgtcaccaag     1920

aagcagcgag gggacatcca tcctcggccg ccacccccga gagattccgg cagccattca     1980

cagtccaggt cgcctggccg accgactcag ggagcccttg gtgagcagca ggacctcagc     2040

aacactacct caaagcggga agaatgcctc caggtgaaaa ccgtcaaggc agagaagcca     2100

atgacatctc agccaagccc tggtggtcag tcttcatgca gcagccaaca gtcccccatc     2160

agcaactatt ccaacagtgg gctcgagctt cctctgaccg atggaggtag tataggagac     2220

ctcagtgcca tcgatgaaac cccaatcatg gactcaacca tttccactgc aaccacagcc     2280

cttgctttgc aagccaggag aaacccggca gggaccaaat ggatggagca cgtaaaacta     2340

gaaaggctaa aacaagtgaa tggaatgttt ccgcgactga accccattct accccctaaa     2400

gcccctgcgg tctctcctct cataggaaat ggcacacagt ccaacaacac ctgcagcttg     2460

ggtgggccca tgacgcttct cccgggcaga agcgacctct ctggggtgga cgtcactatg     2520

ctgaacatgc tcaacagaag ggacagcagc gccagcacca tcagctcggc ctacctgagc     2580

agccgccgct cctcagggat ctcgccctgc ttctccagcc gccgctccag cgaggcgtca     2640

caggccgagg gccggccgca gaacgtgagc gtggccgact cctacgaccc catctccacc     2700

gacgcctcgc gccgctccag cgaagccagc cagagcgacg gcctgcccag cctgctcagc     2760

ctcacgcccg cccagcagta ccgcctcaag gccaagtacg cggctgccac aggagggccg     2820

ccgccgacgc ccctgcccaa catggagagg atgagcctga agacgcgcct ggcgctgctc     2880

ggggatgccc tcgagcctgg cgtggccctg cctccagttc atgccccgag gaggtgcagc     2940

gacgggggag cccacggcta cgggcggcgc cacctgcagc cgcacgatgc gccgggccac     3000

ggcgtgagga gggccagcga cccggtgcgg acaggctccg agggcctggc cctgcctcgt     3060

gtgccgcgct tcagcagcct cagcagctgc aaccccccgg cgatggccac gtccgcggag     3120

aagcgcagtc tcgtgcttca gaattacacg cggcccgagg gcggccagtc ccgaaacttc     3180

cactcgtccc cctgtcctcc cagcatcacc gagaacgtca ccctggagtc cctgaccatg     3240

gacgctgatg ccaacctgaa cgatgaggat ttcctgccgg acgacgtggt gcagtattta     3300

aattcccaga accaagcagg gtacgagcag cacttcccca gcgccctccc ggacgacagc     3360

aaagtgcccc acgggcccgg tgactttgac gcgcccgggc tgccagacag ccacgctggc     3420

cagcagttcc atgccctcga gcagccctgc cccgagggca gcaaaaccga cctgcccatt     3480

cagtggaacg aagtcagctc cggaagcgcc gacctgtcct cctccaagct caagtgtggg     3540

ccgcggcccg ctgtgccgca gactcgcgcc tttgggttct gcaacggcat ggtcgtccac     3600

ccgcagaacc ccttgaggag cgggcctgct gggggctatc agaccctcgg ggagaacagc     3660

aacccctacg gtggcccaga gcacttgatg ctccacaaca gccccggaag tggcaccagt     3720

ggaaacgcct tccatgaaca gccctgtaag gccccgcagt atgggaactg tctcaacagg     3780

cagccagtgg cccctggtgc actcgacggt gcctgtggtg ccgggattca agcctcaaag     3840

ctgaagagca cccccatgca agggagcggg ggccagctga atttcggcct gccggtagcg     3900

ccaaatgagt cagctggcag catggtgaat ggcatgcaga accaggaccc agtgggacag     3960

gggtacctgg ctcaccagct cctcggcgac agcatgcagc acccgggggc aggccgcccc     4020

ggtcagcaga tgcttgggca gattagtgct acctcacaca tcaacatcta ccaagggcca     4080

gagagctgcc tgccaggggc tcacggcatg ggcagccagc cgtcaagctt ggcagttgtc     4140

aggggctacc agccatgtgc cagctttggg ggcagcaggc gccaggctat gccgagggac     4200

agccttgctc tgcagtcagg acagctcagt gacacaagtc agacctgcag ggtgaatggt     4260

atcaagatgg agatgaaagg gcagccccat ccgctgtgct ctaatctgca gaattactct     4320

ggtcagttct atgaccaaac cgtgggcttc agtcagcaag acacgaaagc tggttcattc     4380

tctatttcag acgccagctg cctgctacag gggaccagcg ccaaaaactc tgagttactt     4440

tccccaggtg ctaatcaggt gacaagcaca gtggacagcc tcgacagcca tgacctggaa     4500

ggggtacaga ttgacttcga tgccatcata gacgatgggg accactccag cctgatgtcg     4560

ggggccctga gcccaagtat cattcagaac ctttcccata gctcctcccg cctcaccacg     4620

cctcgggcgt ccctcccatt cccagcgctg tccatgagca ccaccaacat ggctatcggg     4680

gacatgagtt ctttgctgac ctccctagcg gaagaaagca aattccttgc agttatgcaa     4740


<210>  97
<211>  1377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, ETV1

<400>  97
atggatggat tttatgacca gcaagtgcct tacatggtca ccaatagtca gcgtgggaga       60

aattgtaacg agaaaccaac aaatgtcagg aaaagaaaat tcattaacag agatctggct      120

catgattcag aagaactctt tcaagatcta agtcaattac aggaaacatg gcttgcagaa      180

gtggcttttc atggcctgcc actgaaaatc aagaaagaac cccacagtcc atgttcagaa      240

atcagctctg cctgcagtca agaacagccc tttaaattca gctatggaga aaagtgcctg      300

tacaatgtca gtgcctatga tcagaagcca caagtgggaa tgaggccctc caaccccccc      360

acaccatcca gcacgccagt gtccccactg catcatgcat ctccaaactc aactcataca      420

ccgaaacctg accgggcctt cccagctcac ctccctccat cgcagtccat accagatagc      480

agctacccca tggaccacag atttcgccgc cagctttctg aaccctgtaa ctcctttcct      540

cctttgccga cgatgccaag ggaaggacgt cctatgtacc aacgccagat gtctgagcca      600

aacatcccct tcccaccaca aggctttaag caggagtacc acgacccagt gtatgaacac      660

aacaccatgg ttggcagtgc ggccagccaa agctttcccc ctcctctgat gattaaacag      720

gaacccagag attttgcata tgactcagaa gtgcctagct gccactccat ttatatgagg      780

caagaaggct tcctggctca tcccagcaga acagaaggct gtatgtttga aaagggcccc      840

aggcagtttt atgatgacac ctgtgttgtc ccagaaaaat tcgatggaga catcaaacaa      900

gagccaggaa tgtatcggga aggacccaca taccaacggc gaggatcact tcagctctgg      960

cagtttttgg tagctcttct ggatgaccct tcaaattctc attttattgc ctggactggt     1020

cgaggcatgg aatttaaact gattgagcct gaagaggtgg cccgacgttg gggcattcag     1080

aaaaacaggc cagctatgaa ctatgataaa cttagccgtt cactccgcta ttactatgag     1140

aaaggaatta tgcaaaaggt ggctggagag agatatgtct acaagtttgt gtgtgatcca     1200

gaagcccttt tctccatggc ctttccagat aatcagcgtc cactgctgaa gacagacatg     1260

gaacgtcaca tcaacgagga ggacacagtg cctctttctc actttgatga gagcatggcc     1320

tacatgccgg aagggggctg ctgcaacccc cacccctaca acgaaggcta cgtgtat        1377


<210>  98
<211>  465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, ETV2

<400>  98
atggacctgt ggaactggga tgaggcatcc ccacaggaag tgcctccagg gaacaagctg       60

gcagggcttg aaggagccaa attaggcttc tgtttccctg atctggcact ccaaggggac      120

acgccgacag cgacagcaga gacatgctgg aaaggtccca ttcagctgtg gcagttcctc      180

ctggagctgc tccacgacgg ggcgcgtagc agctgcatcc gttggactgg caacagccgc      240

gagttccagc tgtgcgaccc caaagaggtg gctcggctgt ggggcgagcg caagagaaag      300

ccgggcatga attacgagaa gctgagccgg ggccttcgct actactatcg ccgcgacatc      360

gtgcgcaaga gcggggggcg aaagtacacg taccgcttcg ggggccgcgt gcccagccta      420

gcctatccgg actgtgcggg aggcggacgg ggagcagaga cacaa                      465


<210>  99
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, ETV3

<400>  99
atgaaagccg gctgtagcat cgtggaaaag ccagaaggag gtggagggta tcagtttcct       60

gactgggcct acaaaacaga gtcatcccca ggctcccggc agatccagct gtggcacttc      120

atcctggagc tgctgcagaa ggaagagttc cgccatgtca tcgcctggca gcagggagag      180

tacggggaat ttgtcatcaa ggatccagat gaggtggccc gcctctgggg ccgcaggaaa      240

tgcaaaccac agatgaatta tgacaagctg agccgggccc tcagatacta ttacaacaag      300

aggatccttc ataaaacaaa agggaaaaga tttacctata aatttaactt caacaagctg      360

gtgatgccca actacccatt catcaacatt cggtcaagtg gtaagataca aactcttttg      420

gtagggaat                                                              429


<210>  100
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, RUNX1

<400>  100
atggcttcag acagcatatt tgagtcattt ccttcgtacc cacagtgctt catgagagaa       60

tgcatacttg gaatgaatcc ttctagagac gtccacgatg ccagcacgag ccgccgcttc      120

acgccgcctt ccaccgcgct gagcccaggc aagatgagcg aggcgttgcc gctgggcgcc      180

ccggacgccg gcgctgccct ggccggcaag ctgaggagcg gcgaccgcag catggtggag      240

gtgctggccg accacccggg cgagctggtg cgcaccgaca gccccaactt cctctgctcc      300

gtgctgccta cgcactggcg ctgcaacaag accctgccca tcgctttcaa ggtggtggcc      360

ctaggggatg ttccagatgg cactctggtc actgtgatgg ctggcaatga tgaaaactac      420

tcggctgagc tgagaaatgc taccgcagcc atgaagaacc aggttgcaag atttaatgac      480

ctcaggtttg tcggtcgaag tggaagaggg aaaagcttca ctctgaccat cactgtcttc      540

acaaacccac cgcaagtcgc cacctaccac agagccatca aaatcacagt ggatgggccc      600

cgagaacctc gaagacatcg gcagaaacta gatgatcaga ccaagcccgg gagcttgtcc      660

ttttccgagc ggctcagtga actggagcag ctgcggcgca cagccatgag ggtcagccca      720

caccacccag cccccacgcc caaccctcgt gcctccctga accactccac tgcctttaac      780

cctcagcctc agagtcagat gcaggataca aggcagatcc aaccatcccc accgtggtcc      840

tacgatcagt cctaccaata cctgggatcc attgcctctc cttctgtgca cccagcaacg      900

cccatttcac ctggacgtgc cagcggcatg acaaccctct ctgcagaact ttccagtcga      960

ctctcaacgg cacccgacct gacagcgttc agcgacccgc gccagttccc cgcgctgccc     1020

tccatctccg acccccgcat gcactatcca ggcgccttca cctactcccc gacgccggtc     1080

acctcgggca tcggcatcgg catgtcggcc atgggctcgg ccacgcgcta ccacacctac     1140

ctgccgccgc cctaccccgg ctcgtcgcaa gcgcagggag gcccgttcca agccagctcg     1200

ccctcctacc acctgtacta cggcgcctcg gccggctcct accagttctc catggtgggc     1260

ggcgagcgct cgccgccgcg catcctgccg ccctgcacca acgcctccac cggctccgcg     1320

ctgctcaacc ccagcctccc gaaccagagc gacgtggtgg aggccgaggg cagccacagc     1380

aactccccca ccaacatggc gccctccgcg cgcctggagg aggccgtgtg gaggccctac     1440


<210>  101
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, RUNX2

<400>  101
atggcatcaa acagcctctt cagcacagtg acaccatgtc agcaaaactt cttttgggat       60

ccgagcacca gccggcgctt cagccccccc tccagcagcc tgcagcccgg caaaatgagc      120

gacgtgagcc cggtggtggc tgcgcaacag cagcagcaac agcagcagca gcaacagcag      180

cagcagcagc agcaacagca gcagcagcag caggaggcgg cggcggcggc tgcggcggcg      240

gcggcggctg cggcggcggc agctgcagtg ccccggttgc ggccgcccca cgacaaccgc      300

accatggtgg agatcatcgc cgaccacccg gccgaactcg tccgcaccga cagccccaac      360

ttcctgtgct cggtgctgcc ctcgcactgg cgctgcaaca agaccctgcc cgtggccttc      420

aaggtggtag ccctcggaga ggtaccagat gggactgtgg ttactgtcat ggcgggtaac      480

gatgaaaatt attctgctga gctccggaat gcctctgctg ttatgaaaaa ccaagtagca      540

aggttcaacg atctgagatt tgtgggccgg agtggacgag gcaagagttt caccttgacc      600

ataaccgtct tcacaaatcc tccccaagta gctacctatc acagagcaat taaagttaca      660

gtagatggac ctcgggaacc cagaaggcac agacagaagc ttgatgactc taaacctagt      720

ttgttctctg accgcctcag tgatttaggg cgcattcctc atcccagtat gagagtaggt      780

gtcccgcctc agaacccacg gccctccctg aactctgcac caagtccttt taatccacaa      840

ggacagagtc agattacaga ccccaggcag gcacagtctt ccccgccgtg gtcctatgac      900

cagtcttacc cctcctacct gagccagatg acgtccccgt ccatccactc taccaccccg      960

ctgtcttcca cacggggcac tgggcttcct gccatcaccg atgtgcctag gcgcatttca     1020

ggtgcttcag aactgggccc tttttcagac cccaggcagt tcccaagcat ttcatccctc     1080

actgagagcc gcttctccaa cccacgaatg cactatccag ccacctttac ttacaccccg     1140

ccagtcacct caggcatgtc cctcggtatg tccgccacca ctcactacca cacctacctg     1200

ccaccaccct accccggctc ttcccaaagc cagagtggac ccttccagac cagcagcact     1260

ccatatctct actatggcac ttcgtcagga tcctatcagt ttcccatggt gccgggggga     1320

gaccggtctc cttccagaat gcttccgcca tgcaccacca cctcgaatgg cagcacgcta     1380

ttaaatccaa atttgcctaa ccagaatgat ggtgttgacg ctgatggaag ccacagcagt     1440

tccccaactg ttttgaattc tagtggcaga atggatgaat ctgtttggcg accatat        1497


<210>  102
<211>  1245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, RUNX3

<400>  102
atgcgtattc ccgtagaccc aagcaccagc cgccgcttca cacctccctc cccggccttc       60

ccctgcggcg gcggcggcgg caagatgggc gagaacagcg gcgcgctgag cgcgcaggcg      120

gccgtggggc ccggagggcg cgcccggccc gaggtgcgct cgatggtgga cgtgctggcg      180

gaccacgcag gcgagctcgt gcgcaccgac agccccaact tcctctgctc cgtgctgccc      240

tcgcactggc gctgcaacaa gacgctgccc gtcgccttca aggtggtggc attgggggac      300

gtgccggatg gtacggtggt gactgtgatg gcaggcaatg acgagaacta ctccgctgag      360

ctgcgcaatg cctcggccgt catgaagaac caggtggcca ggttcaacga ccttcgcttc      420

gtgggccgca gtgggcgagg gaagagtttc accctgacca tcactgtgtt caccaacccc      480

acccaagtgg cgacctacca ccgagccatc aaggtgaccg tggacggacc ccgggagccc      540

agacggcacc ggcagaagct ggaggaccag accaagccgt tccctgaccg ctttggggac      600

ctggaacggc tgcgcatgcg ggtgacaccg agcacaccca gcccccgagg ctcactcagc      660

accacaagcc acttcagcag ccagccccag accccaatcc aaggcacctc ggaactgaac      720

ccattctccg acccccgcca gtttgaccgc tccttcccca cgctgccaac cctcacggag      780

agccgcttcc cagaccccag gatgcattat cccggggcca tgtcagctgc cttcccctac      840

agcgccacgc cctcgggcac gagcatcagc agcctcagcg tggcgggcat gccggccacc      900

agccgcttcc accataccta cctcccgcca ccctacccgg gggccccgca gaaccagagc      960

gggcccttcc aggccaaccc gtccccctac cacctctact acgggacatc ctctggctcc     1020

taccagttct ccatggtggc cggcagcagc agtgggggcg accgctcacc tacccgcatg     1080

ctggcctctt gcaccagcag cgctgcctct gtcgccgccg gcaacctcat gaaccccagc     1140

ctgggcggcc agagtgatgg cgtggaggcc gacggcagcc acagcaactc acccacggcc     1200

ctgagcacgc caggccgcat ggatgaggcc gtgtggcggc cctac                     1245


<210>  103
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, MAFB

<400>  103
atggccgcgg agctgagcat ggggccagag ctgcccacca gcccgctggc catggagtat       60

gtcaacgact tcgacctgct caagttcgac gtgaagaagg agccactggg gcgcgcggag      120

cgtccgggca ggccctgcac acgcctgcag ccagccggct cggtgtcctc cacaccgctc      180

agcactccgt gtagctccgt gccctcgtcg cccagcttca gcccgaccga acagaagaca      240

cacctcgagg atctgtactg gatggcgagc aactaccagc agatgaaccc cgaggcgctc      300

aacctgacgc ccgaggacgc ggtggaagcg ctcatcggct cgcacccagt gccacagccg      360

ctgcaaagct tcgacagctt tcgcggcgct caccaccacc accatcacca ccaccctcac      420

ccgcaccacg cgtacccggg cgccggcgtg gcccacgacg agctgggccc gcacgctcac      480

ccgcaccatc accatcatca ccaagcgtcg ccgccgccgt ccagcgccgc tagcccggcg      540

caacagctgc ccactagcca ccccgggccc gggccgcacg cgacggcctc ggcgacggcg      600

gcgggcggca acggcagcgt ggaggaccgc ttctccgacg accagctcgt gtccatgtcc      660

gtgcgcgagc tgaaccgcca cctgcggggc ttcaccaagg acgaggtgat ccgcctgaag      720

cagaagcggc ggaccctgaa gaaccggggc tacgcccagt cttgcaggta taaacgcgtc      780

cagcagaagc accacctgga gaatgagaag acgcagctca ttcagcaggt ggagcagctt      840

aagcaggagg tgtcccggct ggcccgcgag agagacgcct acaaggtcaa gtgcgagaaa      900

ctcgccaact ccggcttcag ggaggcgggc tccaccagcg acagcccctc ctctcccgag      960

ttctttctg                                                              969


<210>  104
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, TFAP2C

<400>  104
atgttgtgga aaataaccga taatgtcaag tacgaagagg actgcgagga tcgccacgac       60

gggagcagca atgggaatcc gcgggtcccc cacctctcct ccgccgggca gcacctctac      120

agccccgcgc cacccctctc ccacactgga gtcgccgaat atcagccgcc accctacttt      180

ccccctccct accagcagct ggcctactcc cagtcggccg acccctactc gcatctgggg      240

gaagcgtacg ccgccgccat caaccccctg caccagccgg cgcccacagg cagccagcag      300

caggcctggc ccggccgcca gagccaggag ggagcggggc tgccctcgca ccacgggcgc      360

ccggccggcc tactgcccca cctctccggg ctggaggcgg gcgcggtgag cgcccgcagg      420

gatgcctacc gccgctccga cctgctgctg ccccacgcac acgccctgga tgccgcgggc      480

ctggccgaga acctggggct ccacgacatg cctcaccaga tggacgaggt gcagaatgtc      540

gacgaccagc acctgttgct gcacgatcag acagtcattc gcaaaggtcc catttccatg      600

accaagaacc ctctgaacct cccctgtcag aaggagctgg tgggggccgt aatgaacccc      660

actgaggtct tctgctcagt ccctggaaga ttgtcgctcc tcagctctac gtctaaatac      720

aaagtgacag tggctgaagt acagaggcga ctgtccccac ctgaatgctt aaatgcctcg      780

ttactgggag gtgttctcag aagagccaaa tcgaaaaatg gaggccggtc cttgcgggag      840

aagttggaca agattgggtt gaatcttccg gccgggaggc ggaaagccgc tcatgtgact      900

ctcctgacat ccttagtaga aggtgaagct gttcatttgg ctagggactt tgcctatgtc      960

tgtgaagccg aatttcctag taaaccagtg gcagaatatt taaccagacc tcatcttgga     1020

ggacgaaatg agatggcagc taggaagaac atgctattgg cggcccagca actgtgtaaa     1080

gaattcacag aacttctcag ccaagaccgg acaccccatg ggaccagcag gctcgcccca     1140

gtcttggaga cgaacataca gaactgcttg tctcatttca gcctgattac ccacgggttt     1200

ggcagccagg ccatctgtgc cgcggtgtct gccctgcaga actacatcaa agaagccctg     1260

attgtcatag acaaatccta catgaaccct ggagaccaga gtccagctga ttctaacaaa     1320

accctggaga aaatggagaa acacaggaaa                                      1350


<210>  105
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding polypeptide comprising transcription factor 
       DNA-binding domain, E2F1

<400>  105
atggccttgg ccggggcccc tgcgggcggc ccatgcgcgc cggcgctgga ggccctgctc       60

ggggccggcg cgctgcggct gctcgactcc tcgcagatcg tcatcatctc cgccgcgcag      120

gacgccagcg ccccgccggc tcccaccggc cccgcggcgc ccgccgccgg cccctgcgac      180

cctgacctgc tgctcttcgc cacaccgcag gcgccccggc ccacacccag tgcgccgcgg      240

cccgcgctcg gccgcccgcc ggtgaagcgg aggctggacc tggaaactga ccatcagtac      300

ctggccgaga gcagtgggcc agctcggggc agaggccgcc atccaggaaa aggtgtgaaa      360

tccccggggg agaagtcacg ctatgagacc tcactgaatc tgaccaccaa gcgcttcctg      420

gagctgctga gccactcggc tgacggtgtc gtcgacctga actgggctgc cgaggtgctg      480

aaggtgcaga agcggcgcat ctatgacatc accaacgtcc ttgagggcat ccagctcatt      540

gccaagaagt ccaagaacca catccagtgg ctgggcagcc acaccacagt gggcgtcggc      600

ggacggcttg aggggttgac ccaggacctc cgacagctgc aggagagcga gcagcagctg      660

gaccacctga tgaatatctg tactacgcag ctgcgcctgc tctccgagga cactgacagc      720

cagcgcctgg cctacgtgac gtgtcaggac cttcgtagca ttgcagaccc tgcagagcag      780

atggttatgg tgatcaaagc ccctcctgag acccagctcc aagccgtgga ctcttcggag      840

aactttcaga tctcccttaa gagcaaacaa ggcccgatcg atgttttcct gtgccctgag      900

gagaccgtag gtgggatcag ccctgggaag accccatccc aggaggtcac ttctgaggag      960

gagaacaggg ccactgactc tgccaccata gtgtcaccac caccatcatc tcccccctca     1020

tccctcacca cagatcccag ccagtctcta ctcagcctgg agcaagaacc gctgttgtcc     1080

cggatgggca gcctgcgggc tcccgtggac gaggaccgcc tgtccccgct ggtggcggcc     1140

gactcgctcc tggagcatgt gcgggaggac ttctccggcc tcctccctga ggagttcatc     1200

agcctttccc caccccacga ggccctcgac taccacttcg gcctcgagga gggcgagggc     1260

atcagagacc tcttcgactg tgactttggg gacctcaccc ccctggattt c              1311


<210>  106
<211>  829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epigenetic silencer factor (ESF), KRAB-hSOX21-179-DNMT3a3L

<400>  106

Met Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe 
1               5                   10                  15      


Lys Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp 
            20                  25                  30          


Thr Ala Gln Gln Ile Leu Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys 
        35                  40                  45              


Asn Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu 
    50                  55                  60                  


Arg Leu Glu Lys Gly Glu Glu Pro Trp Leu Val Glu Arg Glu Ile His 
65                  70                  75                  80  


Gln Glu Thr His Pro Asp Ser Glu Thr Ala Phe Glu Ile Lys Ser Ser 
                85                  90                  95      


Val Gly Ser Gly Ala Cys Met Tyr Asn Met Met Glu Thr Glu Leu Lys 
            100                 105                 110         


Pro Pro Gly Pro Gln Gln Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr 
        115                 120                 125             


Ala Ala Ala Ala Gly Gly Asn Gln Lys Asn Ser Pro Asp Arg Val Lys 
    130                 135                 140                 


Arg Pro Met Asn Ala Phe Met Val Trp Ser Arg Gly Gln Arg Arg Lys 
145                 150                 155                 160 


Met Ala Gln Glu Asn Pro Lys Met His Asn Ser Glu Ile Ser Lys Arg 
                165                 170                 175     


Leu Gly Ala Glu Trp Lys Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe 
            180                 185                 190         


Ile Asp Glu Ala Lys Arg Leu Arg Ala Leu His Met Lys Glu His Pro 
        195                 200                 205             


Asp Tyr Lys Tyr Arg Pro Arg Arg Lys Thr Lys Thr Leu Met Lys Lys 
    210                 215                 220                 


Asp Lys Tyr Thr Leu Pro Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser 
225                 230                 235                 240 


Met Ala Ser Gly Val Gly Val Gly Ala Gly Leu Gly Ala Gly Val Asn 
                245                 250                 255     


Gln Arg Met Asp Ser Tyr Ala His Met Asn Gly Trp Ser Asn Gly Ser 
            260                 265                 270         


Tyr Ser Met Met Gln Asp Gln Leu Gly Ala Ser Gly Ser Gly Asn His 
        275                 280                 285             


Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr Pro Pro Val Pro Ala Glu 
    290                 295                 300                 


Lys Arg Lys Pro Ile Arg Val Leu Ser Leu Phe Asp Gly Ile Ala Thr 
305                 310                 315                 320 


Gly Leu Leu Val Leu Lys Asp Leu Gly Ile Gln Val Asp Arg Tyr Ile 
                325                 330                 335     


Ala Ser Glu Val Cys Glu Asp Ser Ile Thr Val Gly Met Val Arg His 
            340                 345                 350         


Gln Gly Lys Ile Met Tyr Val Gly Asp Val Arg Ser Val Thr Gln Lys 
        355                 360                 365             


His Ile Gln Glu Trp Gly Pro Phe Asp Leu Val Ile Gly Gly Ser Pro 
    370                 375                 380                 


Cys Asn Asp Leu Ser Ile Val Asn Pro Ala Arg Lys Gly Leu Tyr Glu 
385                 390                 395                 400 


Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr Arg Leu Leu His Asp Ala 
                405                 410                 415     


Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe Trp Leu Phe Glu Asn 
            420                 425                 430         


Val Val Ala Met Gly Val Ser Asp Lys Arg Asp Ile Ser Arg Phe Leu 
        435                 440                 445             


Glu Ser Asn Pro Val Met Ile Asp Ala Lys Glu Val Ser Ala Ala His 
    450                 455                 460                 


Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly Met Asn Arg Pro Leu 
465                 470                 475                 480 


Ala Ser Thr Val Asn Asp Lys Leu Glu Leu Gln Glu Cys Leu Glu His 
                485                 490                 495     


Gly Arg Ile Ala Lys Phe Ser Lys Val Arg Thr Ile Thr Thr Arg Ser 
            500                 505                 510         


Asn Ser Ile Lys Gln Gly Lys Asp Gln His Phe Pro Val Phe Met Asn 
        515                 520                 525             


Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu Met Glu Arg Val Phe Gly 
    530                 535                 540                 


Phe Pro Val His Tyr Thr Asp Val Ser Asn Met Ser Arg Leu Ala Arg 
545                 550                 555                 560 


Gln Arg Leu Leu Gly Arg Ser Trp Ser Val Pro Val Ile Arg His Leu 
                565                 570                 575     


Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys Val Ser Ser Gly Asn Ser 
            580                 585                 590         


Asn Ala Asn Ser Arg Gly Pro Ser Phe Ser Ser Gly Leu Val Pro Leu 
        595                 600                 605             


Ser Leu Arg Gly Ser His Met Gly Pro Met Glu Ile Tyr Lys Thr Val 
    610                 615                 620                 


Ser Ala Trp Lys Arg Gln Pro Val Arg Val Leu Ser Leu Phe Arg Asn 
625                 630                 635                 640 


Ile Asp Lys Val Leu Lys Ser Leu Gly Phe Leu Glu Ser Gly Ser Gly 
                645                 650                 655     


Ser Gly Gly Gly Thr Leu Lys Tyr Val Glu Asp Val Thr Asn Val Val 
            660                 665                 670         


Arg Arg Asp Val Glu Lys Trp Gly Pro Phe Asp Leu Val Tyr Gly Ser 
        675                 680                 685             


Thr Gln Pro Leu Gly Ser Ser Cys Asp Arg Cys Pro Gly Trp Tyr Met 
    690                 695                 700                 


Phe Gln Phe His Arg Ile Leu Gln Tyr Ala Leu Pro Arg Gln Glu Ser 
705                 710                 715                 720 


Gln Arg Pro Phe Phe Trp Ile Phe Met Asp Asn Leu Leu Leu Thr Glu 
                725                 730                 735     


Asp Asp Gln Glu Thr Thr Thr Arg Phe Leu Gln Thr Glu Ala Val Thr 
            740                 745                 750         


Leu Gln Asp Val Arg Gly Arg Asp Tyr Gln Asn Ala Met Arg Val Trp 
        755                 760                 765             


Ser Asn Ile Pro Gly Leu Lys Ser Lys His Ala Pro Leu Thr Pro Lys 
    770                 775                 780                 


Glu Glu Glu Tyr Leu Gln Ala Gln Val Arg Ser Arg Ser Lys Leu Asp 
785                 790                 795                 800 


Ala Pro Lys Val Asp Leu Leu Val Lys Asn Cys Leu Leu Pro Leu Arg 
                805                 810                 815     


Glu Tyr Phe Lys Tyr Phe Ser Gln Asn Ser Leu Pro Leu 
            820                 825                 


<210>  107

<400>  107
000

<210>  108
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESF, CS-hSOX21-179

<400>  108

Met Leu Glu Pro Glu Lys Ile Ile Gly Ala Thr Asp Ser Cys Gly Asp 
1               5                   10                  15      


Leu Met Phe Leu Met Lys Trp Lys Asp Thr Asp Glu Ala Asp Leu Val 
            20                  25                  30          


Leu Ala Lys Glu Ala Asn Val Lys Cys Pro Gln Ile Val Ile Ala Phe 
        35                  40                  45              


Tyr Glu Glu Arg Leu Thr Trp His Ala Tyr Pro Glu Ala Cys Met Tyr 
    50                  55                  60                  


Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln Thr Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly Asn Gln 
                85                  90                  95      


Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe Met Val 
            100                 105                 110         


Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro Lys Met 
        115                 120                 125             


His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys Leu Leu 
    130                 135                 140                 


Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg Leu Arg 
145                 150                 155                 160 


Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro Arg Arg 
                165                 170                 175     


Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro Gly Gly 
            180                 185                 190         


Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly Val Gly 
        195                 200                 205             


Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr Ala His 
    210                 215                 220                 


Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp Gln Leu 
225                 230                 235                 240 


Gly 
    


<210>  109
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESF, SOX21-179-Y-R

<400>  109

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Ala Ser Gly Ser Asn Met Arg Pro Arg Leu Lys Asn Val 
            180                 185                 190         


Asp Arg Ser Thr Ala Gln Gln Leu Ala Val Thr Val Gly Asn Val Thr 
        195                 200                 205             


Val Ile Ile Thr Asp Phe Lys Glu Lys Thr Arg Ser Ser Ser Thr Ser 
    210                 215                 220                 


Ser Ser Thr Val Thr Ser Ser Ala Gly Ser Glu Gln Gln Asn Gln 
225                 230                 235                 


<210>  110
<211>  816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESF, KRAB-hTEAD1-166-DNMT3a3L

<400>  110

Met Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe 
1               5                   10                  15      


Lys Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp 
            20                  25                  30          


Thr Ala Gln Gln Ile Leu Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys 
        35                  40                  45              


Asn Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu 
    50                  55                  60                  


Arg Leu Glu Lys Gly Glu Glu Pro Trp Leu Val Glu Arg Glu Ile His 
65                  70                  75                  80  


Gln Glu Thr His Pro Asp Ser Glu Thr Ala Phe Glu Ile Lys Ser Ser 
                85                  90                  95      


Val Gly Ser Gly Ala Cys Ile Glu Pro Ser Ser Trp Ser Gly Ser Glu 
            100                 105                 110         


Ser Pro Ala Glu Asn Met Glu Arg Met Ser Asp Ser Ala Asp Lys Pro 
        115                 120                 125             


Ile Asp Asn Asp Ala Glu Gly Val Trp Ser Pro Asp Ile Glu Gln Ser 
    130                 135                 140                 


Phe Gln Glu Ala Leu Ala Ile Tyr Pro Pro Cys Gly Arg Arg Lys Ile 
145                 150                 155                 160 


Ile Leu Ser Asp Glu Gly Lys Met Tyr Gly Arg Asn Glu Leu Ile Ala 
                165                 170                 175     


Arg Tyr Ile Lys Leu Arg Thr Gly Lys Thr Arg Thr Arg Lys Gln Val 
            180                 185                 190         


Ser Ser His Ile Gln Val Leu Ala Arg Arg Lys Ser Arg Asp Phe His 
        195                 200                 205             


Ser Lys Leu Lys Asp Gln Thr Ala Lys Asp Lys Ala Leu Gln His Met 
    210                 215                 220                 


Ala Ala Met Ser Ser Ala Gln Ile Val Ser Ala Thr Ala Ile His Asn 
225                 230                 235                 240 


Lys Leu Gly Leu Pro Gly Ile Pro Arg Pro Thr Phe Pro Gly Ala Pro 
                245                 250                 255     


Gly Phe Trp Pro Gly Met Ile Gln Thr Gly Gln Pro Ala Ser Gly Ser 
            260                 265                 270         


Gly Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr Pro Pro Val 
        275                 280                 285             


Pro Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser Leu Phe Asp Gly 
    290                 295                 300                 


Ile Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly Ile Gln Val Asp 
305                 310                 315                 320 


Arg Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile Thr Val Gly Met 
                325                 330                 335     


Val Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp Val Arg Ser Val 
            340                 345                 350         


Thr Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp Leu Val Ile Gly 
        355                 360                 365             


Gly Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro Ala Arg Lys Gly 
    370                 375                 380                 


Leu Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr Arg Leu Leu 
385                 390                 395                 400 


His Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe Trp Leu 
                405                 410                 415     


Phe Glu Asn Val Val Ala Met Gly Val Ser Asp Lys Arg Asp Ile Ser 
            420                 425                 430         


Arg Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala Lys Glu Val Ser 
        435                 440                 445             


Ala Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly Met Asn 
    450                 455                 460                 


Arg Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu Leu Gln Glu Cys 
465                 470                 475                 480 


Leu Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val Arg Thr Ile Thr 
                485                 490                 495     


Thr Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln His Phe Pro Val 
            500                 505                 510         


Phe Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu Met Glu Arg 
        515                 520                 525             


Val Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn Met Ser Arg 
    530                 535                 540                 


Leu Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser Val Pro Val Ile 
545                 550                 555                 560 


Arg His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys Val Ser Ser 
                565                 570                 575     


Gly Asn Ser Asn Ala Asn Ser Arg Gly Pro Ser Phe Ser Ser Gly Leu 
            580                 585                 590         


Val Pro Leu Ser Leu Arg Gly Ser His Met Gly Pro Met Glu Ile Tyr 
        595                 600                 605             


Lys Thr Val Ser Ala Trp Lys Arg Gln Pro Val Arg Val Leu Ser Leu 
    610                 615                 620                 


Phe Arg Asn Ile Asp Lys Val Leu Lys Ser Leu Gly Phe Leu Glu Ser 
625                 630                 635                 640 


Gly Ser Gly Ser Gly Gly Gly Thr Leu Lys Tyr Val Glu Asp Val Thr 
                645                 650                 655     


Asn Val Val Arg Arg Asp Val Glu Lys Trp Gly Pro Phe Asp Leu Val 
            660                 665                 670         


Tyr Gly Ser Thr Gln Pro Leu Gly Ser Ser Cys Asp Arg Cys Pro Gly 
        675                 680                 685             


Trp Tyr Met Phe Gln Phe His Arg Ile Leu Gln Tyr Ala Leu Pro Arg 
    690                 695                 700                 


Gln Glu Ser Gln Arg Pro Phe Phe Trp Ile Phe Met Asp Asn Leu Leu 
705                 710                 715                 720 


Leu Thr Glu Asp Asp Gln Glu Thr Thr Thr Arg Phe Leu Gln Thr Glu 
                725                 730                 735     


Ala Val Thr Leu Gln Asp Val Arg Gly Arg Asp Tyr Gln Asn Ala Met 
            740                 745                 750         


Arg Val Trp Ser Asn Ile Pro Gly Leu Lys Ser Lys His Ala Pro Leu 
        755                 760                 765             


Thr Pro Lys Glu Glu Glu Tyr Leu Gln Ala Gln Val Arg Ser Arg Ser 
    770                 775                 780                 


Lys Leu Asp Ala Pro Lys Val Asp Leu Leu Val Lys Asn Cys Leu Leu 
785                 790                 795                 800 


Pro Leu Arg Glu Tyr Phe Lys Tyr Phe Ser Gln Asn Ser Leu Pro Leu 
                805                 810                 815     


<210>  111
<211>  962
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESF, KRAB-DNMT3a3L-hMYC144-454

<400>  111

Met Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe 
1               5                   10                  15      


Lys Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp 
            20                  25                  30          


Thr Ala Gln Gln Ile Leu Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys 
        35                  40                  45              


Asn Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu 
    50                  55                  60                  


Arg Leu Glu Lys Gly Glu Glu Pro Trp Leu Val Glu Arg Glu Ile His 
65                  70                  75                  80  


Gln Glu Thr His Pro Asp Ser Glu Thr Ala Phe Glu Ile Lys Ser Ser 
                85                  90                  95      


Val Ala Ser Gly Ser Gly Asn His Asp Gln Glu Phe Asp Pro Pro Lys 
            100                 105                 110         


Val Tyr Pro Pro Val Pro Ala Glu Lys Arg Lys Pro Ile Arg Val Leu 
        115                 120                 125             


Ser Leu Phe Asp Gly Ile Ala Thr Gly Leu Leu Val Leu Lys Asp Leu 
    130                 135                 140                 


Gly Ile Gln Val Asp Arg Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser 
145                 150                 155                 160 


Ile Thr Val Gly Met Val Arg His Gln Gly Lys Ile Met Tyr Val Gly 
                165                 170                 175     


Asp Val Arg Ser Val Thr Gln Lys His Ile Gln Glu Trp Gly Pro Phe 
            180                 185                 190         


Asp Leu Val Ile Gly Gly Ser Pro Cys Asn Asp Leu Ser Ile Val Asn 
        195                 200                 205             


Pro Ala Arg Lys Gly Leu Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu 
    210                 215                 220                 


Phe Tyr Arg Leu Leu His Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg 
225                 230                 235                 240 


Pro Phe Phe Trp Leu Phe Glu Asn Val Val Ala Met Gly Val Ser Asp 
                245                 250                 255     


Lys Arg Asp Ile Ser Arg Phe Leu Glu Ser Asn Pro Val Met Ile Asp 
            260                 265                 270         


Ala Lys Glu Val Ser Ala Ala His Arg Ala Arg Tyr Phe Trp Gly Asn 
        275                 280                 285             


Leu Pro Gly Met Asn Arg Pro Leu Ala Ser Thr Val Asn Asp Lys Leu 
    290                 295                 300                 


Glu Leu Gln Glu Cys Leu Glu His Gly Arg Ile Ala Lys Phe Ser Lys 
305                 310                 315                 320 


Val Arg Thr Ile Thr Thr Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp 
                325                 330                 335     


Gln His Phe Pro Val Phe Met Asn Glu Lys Glu Asp Ile Leu Trp Cys 
            340                 345                 350         


Thr Glu Met Glu Arg Val Phe Gly Phe Pro Val His Tyr Thr Asp Val 
        355                 360                 365             


Ser Asn Met Ser Arg Leu Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp 
    370                 375                 380                 


Ser Val Pro Val Ile Arg His Leu Phe Ala Pro Leu Lys Glu Tyr Phe 
385                 390                 395                 400 


Ala Cys Val Ser Ser Gly Asn Ser Asn Ala Asn Ser Arg Gly Pro Ser 
                405                 410                 415     


Phe Ser Ser Gly Leu Val Pro Leu Ser Leu Arg Gly Ser His Met Gly 
            420                 425                 430         


Pro Met Glu Ile Tyr Lys Thr Val Ser Ala Trp Lys Arg Gln Pro Val 
        435                 440                 445             


Arg Val Leu Ser Leu Phe Arg Asn Ile Asp Lys Val Leu Lys Ser Leu 
    450                 455                 460                 


Gly Phe Leu Glu Ser Gly Ser Gly Ser Gly Gly Gly Thr Leu Lys Tyr 
465                 470                 475                 480 


Val Glu Asp Val Thr Asn Val Val Arg Arg Asp Val Glu Lys Trp Gly 
                485                 490                 495     


Pro Phe Asp Leu Val Tyr Gly Ser Thr Gln Pro Leu Gly Ser Ser Cys 
            500                 505                 510         


Asp Arg Cys Pro Gly Trp Tyr Met Phe Gln Phe His Arg Ile Leu Gln 
        515                 520                 525             


Tyr Ala Leu Pro Arg Gln Glu Ser Gln Arg Pro Phe Phe Trp Ile Phe 
    530                 535                 540                 


Met Asp Asn Leu Leu Leu Thr Glu Asp Asp Gln Glu Thr Thr Thr Arg 
545                 550                 555                 560 


Phe Leu Gln Thr Glu Ala Val Thr Leu Gln Asp Val Arg Gly Arg Asp 
                565                 570                 575     


Tyr Gln Asn Ala Met Arg Val Trp Ser Asn Ile Pro Gly Leu Lys Ser 
            580                 585                 590         


Lys His Ala Pro Leu Thr Pro Lys Glu Glu Glu Tyr Leu Gln Ala Gln 
        595                 600                 605             


Val Arg Ser Arg Ser Lys Leu Asp Ala Pro Lys Val Asp Leu Leu Val 
    610                 615                 620                 


Lys Asn Cys Leu Leu Pro Leu Arg Glu Tyr Phe Lys Tyr Phe Ser Gln 
625                 630                 635                 640 


Asn Ser Leu Pro Leu Gly Ala Pro Ala Ala Ala Ile Ile Gln Asp Cys 
                645                 650                 655     


Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val Ser Glu Lys Leu 
            660                 665                 670         


Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser Pro Asn Pro Ala 
        675                 680                 685             


Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr Leu Gln Asp Leu 
    690                 695                 700                 


Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val Val Phe Pro Tyr 
705                 710                 715                 720 


Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala Ser Gln Asp Ser 
                725                 730                 735     


Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser Ser Thr Glu Ser 
            740                 745                 750         


Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His Glu Glu Thr Pro 
        755                 760                 765             


Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu Asp Glu Glu Glu 
    770                 775                 780                 


Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro Gly Lys Arg Ser 
785                 790                 795                 800 


Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys Pro Pro His Ser 
                805                 810                 815     


Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His Gln His Asn Tyr 
            820                 825                 830         


Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala Ala Lys Arg Val 
        835                 840                 845             


Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser Asn Asn Arg Lys 
    850                 855                 860                 


Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn Val Lys Arg Arg 
865                 870                 875                 880 


Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser 
                885                 890                 895     


Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu Asn Asn Glu Lys 
            900                 905                 910         


Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala Tyr Ile Leu Ser 
        915                 920                 925             


Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Arg 
    930                 935                 940                 


Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln Leu Arg Asn Ser 
945                 950                 955                 960 


Cys Ala 
        


<210>  112
<211>  2487
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding ESF, KRAB-hSOX21-179-DNMT3a3L

<400>  112
atggatgcta agtcactgac tgcctggtcc cggacactgg tgaccttcaa ggatgtgttt       60

gtggacttca ccagggagga gtggaagctg ctggacactg ctcagcagat cctgtacaga      120

aatgtgatgc tggagaacta taagaacctg gtttccttgg gttatcagct tactaagcca      180

gatgtgatcc tccggttgga gaagggagaa gagccctggc tggtggagag agaaattcac      240

caagagaccc atcctgattc agagactgca tttgaaatca aatcatcagt tggcagcggc      300

gcatgcatgt acaacatgat ggagacggag ctgaagccgc cgggcccgca gcaaacttcg      360

gggggcggcg gcggcaactc caccgcggcg gcggccggcg gcaaccagaa aaacagcccg      420

gaccgcgtca agcggcccat gaatgccttc atggtgtggt cccgcgggca gcggcgcaag      480

atggcccagg agaaccccaa gatgcacaac tcggagatca gcaagcgcct gggcgccgag      540

tggaaacttt tgtcggagac ggagaagcgg ccgttcatcg acgaggctaa gcggctgcga      600

gcgctgcaca tgaaggagca cccggattat aaataccggc cccggcggaa aaccaagacg      660

ctcatgaaga aggataagta cacgctgccc ggcgggctgc tggcccccgg cggcaatagc      720

atggcgagcg gggtcggggt gggcgccggc ctgggcgcgg gcgtgaacca gcgcatggac      780

agttacgcgc acatgaacgg ctggagcaac ggcagctaca gcatgatgca ggaccagctg      840

ggcgctagcg gcagcggcaa ccatgatcaa gagttcgatc ctcctaaagt gtatccccct      900

gtccctgccg aaaagcggaa accgatcagg gttctcagtc tcttcgatgg aattgccaca      960

ggcctcttgg tccttaagga cctgggcatc caagtggacc gctacatcgc ctcagaagta     1020

tgtgaggaca gcatcacagt cggcatggtg cgccaccagg ggaaaataat gtacgtcggc     1080

gacgtcagat cagttactca gaaacatatt caggaatggg ggccttttga tctcgtaatt     1140

ggcggcagcc cctgcaatga tctgagtatt gtgaaccccg cccggaaagg tttgtacgaa     1200

ggtacgggca gactgttctt cgagttttac agactgttgc acgacgcacg accaaaggag     1260

ggtgacgatc gacccttctt ctggctgttc gagaacgtgg tcgctatggg cgtgtctgac     1320

aagcgggaca tttctagatt cctggagagc aatccagtga tgattgatgc aaaggaagta     1380

tccgctgccc accgcgccag atacttctgg ggcaatctgc ccggcatgaa tcgacccttg     1440

gcaagcaccg tgaatgataa gttggagttg caggagtgtc tggagcatgg gcggatcgca     1500

aagtttagca aggtgcggac catcacgacc cgaagcaatt caattaagca gggaaaggac     1560

caacattttc cagtgtttat gaacgagaaa gaggacatcc tgtggtgcac agaaatggag     1620

cgggttttcg gattccccgt acattatact gatgtgtcca atatgtctag gttggctaga     1680

cagaggctgt tgggacgctc atggagtgtt cctgtcatcc gccacctgtt cgctcctctg     1740

aaggagtatt tcgcctgcgt ttcatccggg aattcaaacg caaacagcag aggcccatcc     1800

ttttcttccg gcctggtgcc acttagtctg cgcggctctc acatgggacc tatggaaata     1860

tacaaaacag tgagcgcctg gaagaggcag cctgtgcggg tcctgagtct gttcagaaac     1920

attgacaagg tgcttaagtc ccttggattt ctggagtctg gcagcggttc tgggggtggc     1980

acccttaagt atgtggagga cgtgacaaac gtcgtgagga gagatgtgga gaaatggggg     2040

ccatttgacc tggtatacgg gagcactcaa cctctcggtt cttcttgtga tcgctgccca     2100

gggtggtata tgtttcagtt ccatcgcatc ctgcaatacg cccttccgcg gcaggagagt     2160

cagcgaccat tcttctggat attcatggac aatctcctgc tgacagagga cgaccaagag     2220

actacgacta gatttcttca gaccgaggcc gttactctcc aggacgttag aggtagggac     2280

taccagaatg ccatgcgagt gtggagtaac atccccggac tcaagtcaaa gcacgcaccc     2340

ctgaccccca aggaagagga atacctccag gcgcaggtga ggagccgcag taagctcgat     2400

gctcctaaag tcgatttgtt ggtgaagaat tgcttgctgc ccctgagaga gtactttaag     2460

tactttagcc agaacagctt gccactg                                         2487


<210>  113
<211>  2487
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding ESF, KRAB-hSOX21-179-DNMT3a3L

<400>  113
atggatgcta agtcactgac tgcctggtcc cggacactgg tgaccttcaa ggatgtgttt       60

gtggacttca ccagggagga gtggaagctg ctggacactg ctcagcagat cctgtacaga      120

aatgtgatgc tggagaacta taagaacctg gtttccttgg gttatcagct tactaagcca      180

gatgtgatcc tccggttgga gaagggagaa gagccctggc tggtggagag agaaattcac      240

caagagaccc atcctgattc agagactgca tttgaaatca aatcatcagt tggcagcggc      300

gcatgcatgt acaacatgat ggagacggag ctgaagccgc cgggcccgca gcaaacttcg      360

gggggcggcg gcggcaactc caccgcggcg gcggccggcg gcaaccagaa aaacagcccg      420

gaccgcgtca agcggcccat gaatgccttc atggtgtggt cccgcgggca gcggcgcaag      480

atggcccagg agaaccccaa gatgcacaac tcggagatca gcaagcgcct gggcgccgag      540

tggaaacttt tgtcggagac ggagaagcgg ccgttcatcg acgaggctaa gcggctgcga      600

gcgctgcaca tgaaggagca cccggattat aaataccggc cccggcggaa aaccaagacg      660

ctcatgaaga aggataagta cacgctgccc ggcgggctgc tggcccccgg cggcaatagc      720

atggcgagcg gggtcggggt gggcgccggc ctgggcgcgg gcgtgaacca gcgcatggac      780

agttacgcgc acatgaacgg ctggagcaac ggcagctaca gcatgatgca ggaccagctg      840

ggcgctagcg gcagcggcaa ccatgatcaa gagttcgatc ctcctaaagt gtatccccct      900

gtccctgccg aaaagcggaa accgatcagg gttctcagtc tcttcgatgg aattgccaca      960

ggcctcttgg tccttaagga cctgggcatc caagtggacc gctacatcgc ctcagaagta     1020

tgtgaggaca gcatcacagt cggcatggtg cgccaccagg ggaaaataat gtacgtcggc     1080

gacgtcagat cagttactca gaaacatatt caggaatggg ggccttttga tctcgtaatt     1140

ggcggcagcc cctgcaatga tctgagtatt gtgaaccccg cccggaaagg tttgtacgaa     1200

ggtacgggca gactgttctt cgagttttac agactgttgc acgacgcacg accaaaggag     1260

ggtgacgatc gacccttctt ctggctgttc gagaacgtgg tcgctatggg cgtgtctgac     1320

aagcgggaca tttctagatt cctggagagc aatccagtga tgattgatgc aaaggaagta     1380

tccgctgccc accgcgccag atacttctgg ggcaatctgc ccggcatgaa tcgacccttg     1440

gcaagcaccg tgaatgataa gttggagttg caggagtgtc tggagcatgg gcggatcgca     1500

aagtttagca aggtgcggac catcacgacc cgaagcaatt caattaagca gggaaaggac     1560

caacattttc cagtgtttat gaacgagaaa gaggacatcc tgtggtgcac agaaatggag     1620

cgggttttcg gattccccgt acattatact gatgtgtcca atatgtctag gttggctaga     1680

cagaggctgt tgggacgctc atggagtgtt cctgtcatcc gccacctgtt cgctcctctg     1740

aaggagtatt tcgcctgcgt ttcatccggg aattcaaacg caaacagcag aggcccatcc     1800

ttttcttccg gcctggtgcc acttagtctg cgcggctctc acatgggacc tatggaaata     1860

tacaaaacag tgagcgcctg gaagaggcag cctgtgcggg tcctgagtct gttcagaaac     1920

attgacaagg tgcttaagtc ccttggattt ctggagtctg gcagcggttc tgggggtggc     1980

acccttaagt atgtggagga cgtgacaaac gtcgtgagga gagatgtgga gaaatggggg     2040

ccatttgacc tggtatacgg gagcactcaa cctctcggtt cttcttgtga tcgctgccca     2100

gggtggtata tgtttcagtt ccatcgcatc ctgcaatacg cccttccgcg gcaggagagt     2160

cagcgaccat tcttctggat attcatggac aatctcctgc tgacagagga cgaccaagag     2220

actacgacta gatttcttca gaccgaggcc gttactctcc aggacgttag aggtagggac     2280

taccagaatg ccatgcgagt gtggagtaac atccccggac tcaagtcaaa gcacgcaccc     2340

ctgaccccca aggaagagga atacctccag gcgcaggtga ggagccgcag taagctcgat     2400

gctcctaaag tcgatttgtt ggtgaagaat tgcttgctgc ccctgagaga gtactttaag     2460

tactttagcc agaacagctt gccactg                                         2487


<210>  114
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding ESF, CS-hSOX21-179

<400>  114
atgctggaac cagaaaagat cattggggca acagattcct gtggtgattt aatgttccta       60

atgaaatgga aagacacaga tgaagctgac ctggttcttg caaaagaagc taatgtgaaa      120

tgtccacaaa ttgtgatagc attttatgaa gagagactga catggcatgc atatcctgag      180

gcatgcatgt acaacatgat ggagacggag ctgaagccgc cgggcccgca gcaaacttcg      240

gggggcggcg gcggcaactc caccgcggcg gcggccggcg gcaaccagaa aaacagcccg      300

gaccgcgtca agcggcccat gaatgccttc atggtgtggt cccgcgggca gcggcgcaag      360

atggcccagg agaaccccaa gatgcacaac tcggagatca gcaagcgcct gggcgccgag      420

tggaaacttt tgtcggagac ggagaagcgg ccgttcatcg acgaggctaa gcggctgcga      480

gcgctgcaca tgaaggagca cccggattat aaataccggc cccggcggaa aaccaagacg      540

ctcatgaaga aggataagta cacgctgccc ggcgggctgc tggcccccgg cggcaatagc      600

atggcgagcg gggtcggggt gggcgccggc ctgggcgcgg gcgtgaacca gcgcatggac      660

agttacgcgc acatgaacgg ctggagcaac ggcagctaca gcatgatgca ggaccagctg      720

ggc                                                                    723


<210>  115
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding ESF, SOX21-179-Y-R

<400>  115
atgtacaaca tgatggagac ggagctgaag ccgccgggcc cgcagcaaac ttcggggggc       60

ggcggcggca actccaccgc ggcggcggcc ggcggcaacc agaaaaacag cccggaccgc      120

gtcaagcggc ccatgaatgc cttcatggtg tggtcccgcg ggcagcggcg caagatggcc      180

caggagaacc ccaagatgca caactcggag atcagcaagc gcctgggcgc cgagtggaaa      240

cttttgtcgg agacggagaa gcggccgttc atcgacgagg ctaagcggct gcgagcgctg      300

cacatgaagg agcacccgga ttataaatac cggccccggc ggaaaaccaa gacgctcatg      360

aagaaggata agtacacgct gcccggcggg ctgctggccc ccggcggcaa tagcatggcg      420

agcggggtcg gggtgggcgc cggcctgggc gcgggcgtga accagcgcat ggacagttac      480

gcgcacatga acggctggag caacggcagc tacagcatga tgcaggacca gctgggcgct      540

agcggatcca acatgaggcc ccggctgaaa aacgtggaca ggagcactgc acagcagttg      600

gcagtaactg tgggcaacgt caccgtcatt atcacagact ttaaggaaaa gactcgctcc      660

tcatcgacat cctcatccac agtgacctcc agtgcagggt cagaacagca gaaccag         717


<210>  116
<211>  2448
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding ESF, KRAB-hTEAD1-166-DNMT3a3L

<400>  116
atggatgcta agtcactgac tgcctggtcc cggacactgg tgaccttcaa ggatgtgttt       60

gtggacttca ccagggagga gtggaagctg ctggacactg ctcagcagat cctgtacaga      120

aatgtgatgc tggagaacta taagaacctg gtttccttgg gttatcagct tactaagcca      180

gatgtgatcc tccggttgga gaagggagaa gagccctggc tggtggagag agaaattcac      240

caagagaccc atcctgattc agagactgca tttgaaatca aatcatcagt tggcagcggc      300

gcatgcattg agcccagcag ctggagcggc agtgagagcc ctgccgaaaa catggaaagg      360

atgagtgact ctgcagataa gccaattgac aatgatgcag aaggggtctg gagccccgac      420

atcgagcaaa gctttcagga ggccctggct atctatccac catgtgggag gaggaaaatc      480

atcttatcag acgaaggcaa aatgtatggt aggaatgaat tgatagccag atacatcaaa      540

ctcaggacag gcaagacgag gaccagaaaa caggtgtcta gtcacattca ggttcttgcc      600

agaaggaaat ctcgtgattt tcattccaag ctaaaggatc agactgcaaa ggataaggcc      660

ctgcagcaca tggcggccat gtcctcagcc cagatcgtct cggccactgc cattcataac      720

aagctggggc tgcctgggat tccacgcccg accttcccag gggcgccggg gttctggccg      780

ggaatgattc aaacagggca gccagctagc ggcagcggca accatgatca agagttcgat      840

cctcctaaag tgtatccccc tgtccctgcc gaaaagcgga aaccgatcag ggttctcagt      900

ctcttcgatg gaattgccac aggcctcttg gtccttaagg acctgggcat ccaagtggac      960

cgctacatcg cctcagaagt atgtgaggac agcatcacag tcggcatggt gcgccaccag     1020

gggaaaataa tgtacgtcgg cgacgtcaga tcagttactc agaaacatat tcaggaatgg     1080

gggccttttg atctcgtaat tggcggcagc ccctgcaatg atctgagtat tgtgaacccc     1140

gcccggaaag gtttgtacga aggtacgggc agactgttct tcgagtttta cagactgttg     1200

cacgacgcac gaccaaagga gggtgacgat cgacccttct tctggctgtt cgagaacgtg     1260

gtcgctatgg gcgtgtctga caagcgggac atttctagat tcctggagag caatccagtg     1320

atgattgatg caaaggaagt atccgctgcc caccgcgcca gatacttctg gggcaatctg     1380

cccggcatga atcgaccctt ggcaagcacc gtgaatgata agttggagtt gcaggagtgt     1440

ctggagcatg ggcggatcgc aaagtttagc aaggtgcgga ccatcacgac ccgaagcaat     1500

tcaattaagc agggaaagga ccaacatttt ccagtgttta tgaacgagaa agaggacatc     1560

ctgtggtgca cagaaatgga gcgggttttc ggattccccg tacattatac tgatgtgtcc     1620

aatatgtcta ggttggctag acagaggctg ttgggacgct catggagtgt tcctgtcatc     1680

cgccacctgt tcgctcctct gaaggagtat ttcgcctgcg tttcatccgg gaattcaaac     1740

gcaaacagca gaggcccatc cttttcttcc ggcctggtgc cacttagtct gcgcggctct     1800

cacatgggac ctatggaaat atacaaaaca gtgagcgcct ggaagaggca gcctgtgcgg     1860

gtcctgagtc tgttcagaaa cattgacaag gtgcttaagt cccttggatt tctggagtct     1920

ggcagcggtt ctgggggtgg cacccttaag tatgtggagg acgtgacaaa cgtcgtgagg     1980

agagatgtgg agaaatgggg gccatttgac ctggtatacg ggagcactca acctctcggt     2040

tcttcttgtg atcgctgccc agggtggtat atgtttcagt tccatcgcat cctgcaatac     2100

gcccttccgc ggcaggagag tcagcgacca ttcttctgga tattcatgga caatctcctg     2160

ctgacagagg acgaccaaga gactacgact agatttcttc agaccgaggc cgttactctc     2220

caggacgtta gaggtaggga ctaccagaat gccatgcgag tgtggagtaa catccccgga     2280

ctcaagtcaa agcacgcacc cctgaccccc aaggaagagg aatacctcca ggcgcaggtg     2340

aggagccgca gtaagctcga tgctcctaaa gtcgatttgt tggtgaagaa ttgcttgctg     2400

cccctgagag agtactttaa gtactttagc cagaacagct tgccactg                  2448


<210>  117
<211>  2886
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding ESF, KRAB-DNMT3a3L-hMYC144-454

<400>  117
atggatgcta agtcactgac tgcctggtcc cggacactgg tgaccttcaa ggatgtgttt       60

gtggacttca ccagggagga gtggaagctg ctggacactg ctcagcagat cctgtacaga      120

aatgtgatgc tggagaacta taagaacctg gtttccttgg gttatcagct tactaagcca      180

gatgtgatcc tccggttgga gaagggagaa gagccctggc tggtggagag agaaattcac      240

caagagaccc atcctgattc agagactgca tttgaaatca aatcatcagt tgctagcggc      300

agcggcaacc atgatcaaga gttcgatcct cctaaagtgt atccccctgt ccctgccgaa      360

aagcggaaac cgatcagggt tctcagtctc ttcgatggaa ttgccacagg cctcttggtc      420

cttaaggacc tgggcatcca agtggaccgc tacatcgcct cagaagtatg tgaggacagc      480

atcacagtcg gcatggtgcg ccaccagggg aaaataatgt acgtcggcga cgtcagatca      540

gttactcaga aacatattca ggaatggggg ccttttgatc tcgtaattgg cggcagcccc      600

tgcaatgatc tgagtattgt gaaccccgcc cggaaaggtt tgtacgaagg tacgggcaga      660

ctgttcttcg agttttacag actgttgcac gacgcacgac caaaggaggg tgacgatcga      720

cccttcttct ggctgttcga gaacgtggtc gctatgggcg tgtctgacaa gcgggacatt      780

tctagattcc tggagagcaa tccagtgatg attgatgcaa aggaagtatc cgctgcccac      840

cgcgccagat acttctgggg caatctgccc ggcatgaatc gacccttggc aagcaccgtg      900

aatgataagt tggagttgca ggagtgtctg gagcatgggc ggatcgcaaa gtttagcaag      960

gtgcggacca tcacgacccg aagcaattca attaagcagg gaaaggacca acattttcca     1020

gtgtttatga acgagaaaga ggacatcctg tggtgcacag aaatggagcg ggttttcgga     1080

ttccccgtac attatactga tgtgtccaat atgtctaggt tggctagaca gaggctgttg     1140

ggacgctcat ggagtgttcc tgtcatccgc cacctgttcg ctcctctgaa ggagtatttc     1200

gcctgcgttt catccgggaa ttcaaacgca aacagcagag gcccatcctt ttcttccggc     1260

ctggtgccac ttagtctgcg cggctctcac atgggaccta tggaaatata caaaacagtg     1320

agcgcctgga agaggcagcc tgtgcgggtc ctgagtctgt tcagaaacat tgacaaggtg     1380

cttaagtccc ttggatttct ggagtctggc agcggttctg ggggtggcac ccttaagtat     1440

gtggaggacg tgacaaacgt cgtgaggaga gatgtggaga aatgggggcc atttgacctg     1500

gtatacggga gcactcaacc tctcggttct tcttgtgatc gctgcccagg gtggtatatg     1560

tttcagttcc atcgcatcct gcaatacgcc cttccgcggc aggagagtca gcgaccattc     1620

ttctggatat tcatggacaa tctcctgctg acagaggacg accaagagac tacgactaga     1680

tttcttcaga ccgaggccgt tactctccag gacgttagag gtagggacta ccagaatgcc     1740

atgcgagtgt ggagtaacat ccccggactc aagtcaaagc acgcacccct gacccccaag     1800

gaagaggaat acctccaggc gcaggtgagg agccgcagta agctcgatgc tcctaaagtc     1860

gatttgttgg tgaagaattg cttgctgccc ctgagagagt actttaagta ctttagccag     1920

aacagcttgc cactgggcgc gcccgccgct gccatcatcc aggactgtat gtggagcggc     1980

ttctcggccg ccgccaagct cgtctcagag aagctggcct cctaccaggc tgcgcgcaaa     2040

gacagcggca gcccgaaccc cgcccgcggc cacagcgtct gctccacctc cagcttgtac     2100

ctgcaggatc tgagcgccgc cgcctcagag tgcatcgacc cctcggtggt cttcccctac     2160

cctctcaacg acagcagctc gcccaagtcc tgcgcctcgc aagactccag cgccttctct     2220

ccgtcctcgg attctctgct ctcctcgacg gagtcctccc cgcagggcag ccccgagccc     2280

ctggtgctcc atgaggagac accgcccacc accagcagcg actctgagga ggaacaagaa     2340

gatgaggaag aaatcgatgt tgtttctgtg gaaaagaggc aggctcctgg caaaaggtca     2400

gagtctggat caccttctgc tggaggccac agcaaacctc ctcacagccc actggtcctc     2460

aagaggtgcc acgtctccac acatcagcac aactacgcag cgcctccctc cactcggaag     2520

gactatcctg ctgccaagag ggtcaagttg gacagtgtca gagtcctgag acagatcagc     2580

aacaaccgaa aatgcaccag ccccaggtcc tcggacaccg aggagaatgt caagaggcga     2640

acacacaacg tcttggagcg ccagaggagg aacgagctaa aacggagctt ttttgccctg     2700

cgtgaccaga tcccggagtt ggaaaacaat gaaaaggccc ccaaggtagt tatccttaaa     2760

aaagccacag catacatcct gtccgtccaa gcagaggagc aaaagctcat ttctgaagag     2820

gacttgttgc ggaaacgacg agaacagttg aaacacaaac ttgaacagct acggaactct     2880

tgtgcg                                                                2886


<210>  118
<211>  1303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ef1a promoter

<400>  118
cgataagctt tgcaaagatg gataaagttt taaacagaga ggaatctttg cagctaatgg       60

accttctagg tcttgaaagg agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc      120

acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag      180

agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc      240

gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac      300

gggtttgccg ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt      360

acgggttatg gcccttgcgt gccttgaatt acttccactg gctgcagtac gtgattcttg      420

atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc      480

cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct      540

ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt      600

gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc      660

tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc      720

gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt      780

ctcaagctgg ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct      840

gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg      900

gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt      960

cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg     1020

agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt     1080

taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg     1140

aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg     1200

gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg     1260

tgtcgtgagg aattctgcag tcgatcgacg gtaccgcggg ccc                       1303


<210>  119
<211>  1262
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mki67 promoter

<400>  119
acttcaggct tgtccttgag accttgagga gagggtagac attggttcta ttgccccaga       60

agcggaattt ttacaacacc ctactggaag aacactgatc caggaacagg aggagggagc      120

atgaaaaaag aggacaggaa aacataggta ctctatattc atctgactgg cacctggcct      180

cagataaccc caactggtgc cccaggagcc ctattttagg atttgcaggt gcagtcttgc      240

acaggttatt ttaatcggca tttccccctg aaacagcaaa gcattgcaaa cttaaccgtg      300

ccgcagcaat aactcttaag ttatggtttc ggaaaaaccg tgccactgcc tcagtgttca      360

ttaagcaggg agactgtaga atgaattata atgatgtccc ccagttttta aaggacagtt      420

tgagggatac tgaaaaggca ggagaaacaa ccttaggttg cgtatgaggt gttgcagaaa      480

cggcagagga agggtataaa ttttaaaaat agaaagcttc tagcgttgag caagatgcgg      540

cgttgtcggt gtttgatttc tggagaggga gcctacaggt agcttcctac aggtcgccac      600

gctagttttg ctgacactga aaaagctggg accctctacc ctgcctatta gagcagcagt      660

ggcccgccca ccagccccac cctgcccgcc ttccggagct tatctccgct cgggttccgc      720

ttctccagcc agcttctggc ccggccccgc ctaccggcct ggcccctccc accttccggc      780

tccacccccc cccccccccc caggctcgca gcctggcccc acctctggac ttccccaatc      840

ctctgtcgcc ctcgccattg gtctctggct ggccgcctgg cccaatcgca gcacttagcg      900

ccagaatttg aaccgccgtt ttggtttgaa tcgggcgggc tgcggcgggc gagccttggc      960

gcggaaccgc ctaggcggac agtcggggct ggacggggcg gcgggtggcg ggtggcgggc     1020

acttgggacg cgggcggcgg gagtgcgggt ctggtcgggg cggagcgaag gccgcgggtg     1080

gccgtggtcg gtcctccgcg gctaaggagc cgagggctcc gacgcgggct gcgcccggtg     1140

agcggcggcc agagctaact tgcgctgact ggaccagctg aggagcggcc cggcggggcg     1200

actgcgagct tcaccgagag gcttctccgc cctggtccgc agtcccgacg gccgggcgga     1260

cc                                                                    1262


<210>  120
<211>  3856
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct Ef1a::KRAB-hSOX21-179-DNMT3a3L-V5 [SES]

<400>  120
cgataagctt tgcaaagatg gataaagttt taaacagaga ggaatctttg cagctaatgg       60

accttctagg tcttgaaagg agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc      120

acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag      180

agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc      240

gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac      300

gggtttgccg ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt      360

acgggttatg gcccttgcgt gccttgaatt acttccactg gctgcagtac gtgattcttg      420

atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc      480

cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct      540

ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt      600

gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc      660

tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc      720

gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt      780

ctcaagctgg ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct      840

gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg      900

gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt      960

cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg     1020

agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt     1080

taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg     1140

aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg     1200

gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg     1260

tgtcgtgagg aattctgcag tcgatcgacg gtaccgcggg cccaacggat ccaccatgga     1320

tgctaagtca ctgactgcct ggtcccggac actggtgacc ttcaaggatg tgtttgtgga     1380

cttcaccagg gaggagtgga agctgctgga cactgctcag cagatcctgt acagaaatgt     1440

gatgctggag aactataaga acctggtttc cttgggttat cagcttacta agccagatgt     1500

gatcctccgg ttggagaagg gagaagagcc ctggctggtg gagagagaaa ttcaccaaga     1560

gacccatcct gattcagaga ctgcatttga aatcaaatca tcagttggca gcggcgcatg     1620

catgtacaac atgatggaga cggagctgaa gccgccgggc ccgcagcaaa cttcgggggg     1680

cggcggcggc aactccaccg cggcggcggc cggcggcaac cagaaaaaca gcccggaccg     1740

cgtcaagcgg cccatgaatg ccttcatggt gtggtcccgc gggcagcggc gcaagatggc     1800

ccaggagaac cccaagatgc acaactcgga gatcagcaag cgcctgggcg ccgagtggaa     1860

acttttgtcg gagacggaga agcggccgtt catcgacgag gctaagcggc tgcgagcgct     1920

gcacatgaag gagcacccgg attataaata ccggccccgg cggaaaacca agacgctcat     1980

gaagaaggat aagtacacgc tgcccggcgg gctgctggcc cccggcggca atagcatggc     2040

gagcggggtc ggggtgggcg ccggcctggg cgcgggcgtg aaccagcgca tggacagtta     2100

cgcgcacatg aacggctgga gcaacggcag ctacagcatg atgcaggacc agctgggcgc     2160

tagcggcagc ggcaaccatg atcaagagtt cgatcctcct aaagtgtatc cccctgtccc     2220

tgccgaaaag cggaaaccga tcagggttct cagtctcttc gatggaattg ccacaggcct     2280

cttggtcctt aaggacctgg gcatccaagt ggaccgctac atcgcctcag aagtatgtga     2340

ggacagcatc acagtcggca tggtgcgcca ccaggggaaa ataatgtacg tcggcgacgt     2400

cagatcagtt actcagaaac atattcagga atgggggcct tttgatctcg taattggcgg     2460

cagcccctgc aatgatctga gtattgtgaa ccccgcccgg aaaggtttgt acgaaggtac     2520

gggcagactg ttcttcgagt tttacagact gttgcacgac gcacgaccaa aggagggtga     2580

cgatcgaccc ttcttctggc tgttcgagaa cgtggtcgct atgggcgtgt ctgacaagcg     2640

ggacatttct agattcctgg agagcaatcc agtgatgatt gatgcaaagg aagtatccgc     2700

tgcccaccgc gccagatact tctggggcaa tctgcccggc atgaatcgac ccttggcaag     2760

caccgtgaat gataagttgg agttgcagga gtgtctggag catgggcgga tcgcaaagtt     2820

tagcaaggtg cggaccatca cgacccgaag caattcaatt aagcagggaa aggaccaaca     2880

ttttccagtg tttatgaacg agaaagagga catcctgtgg tgcacagaaa tggagcgggt     2940

tttcggattc cccgtacatt atactgatgt gtccaatatg tctaggttgg ctagacagag     3000

gctgttggga cgctcatgga gtgttcctgt catccgccac ctgttcgctc ctctgaagga     3060

gtatttcgcc tgcgtttcat ccgggaattc aaacgcaaac agcagaggcc catccttttc     3120

ttccggcctg gtgccactta gtctgcgcgg ctctcacatg ggacctatgg aaatatacaa     3180

aacagtgagc gcctggaaga ggcagcctgt gcgggtcctg agtctgttca gaaacattga     3240

caaggtgctt aagtcccttg gatttctgga gtctggcagc ggttctgggg gtggcaccct     3300

taagtatgtg gaggacgtga caaacgtcgt gaggagagat gtggagaaat gggggccatt     3360

tgacctggta tacgggagca ctcaacctct cggttcttct tgtgatcgct gcccagggtg     3420

gtatatgttt cagttccatc gcatcctgca atacgccctt ccgcggcagg agagtcagcg     3480

accattcttc tggatattca tggacaatct cctgctgaca gaggacgacc aagagactac     3540

gactagattt cttcagaccg aggccgttac tctccaggac gttagaggta gggactacca     3600

gaatgccatg cgagtgtgga gtaacatccc cggactcaag tcaaagcacg cacccctgac     3660

ccccaaggaa gaggaatacc tccaggcgca ggtgaggagc cgcagtaagc tcgatgctcc     3720

taaagtcgat ttgttggtga agaattgctt gctgcccctg agagagtact ttaagtactt     3780

tagccagaac agcttgccac tgggcgcgcc cggtaagcct atccctaacc ctctcctcgg     3840

tctcgattct acgtga                                                     3856


<210>  121
<211>  3815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct pMki67::KRAB-hSOX21-179- DNMT3a3L-V5 [SES v1.1]

<400>  121
acttcaggct tgtccttgag accttgagga gagggtagac attggttcta ttgccccaga       60

agcggaattt ttacaacacc ctactggaag aacactgatc caggaacagg aggagggagc      120

atgaaaaaag aggacaggaa aacataggta ctctatattc atctgactgg cacctggcct      180

cagataaccc caactggtgc cccaggagcc ctattttagg atttgcaggt gcagtcttgc      240

acaggttatt ttaatcggca tttccccctg aaacagcaaa gcattgcaaa cttaaccgtg      300

ccgcagcaat aactcttaag ttatggtttc ggaaaaaccg tgccactgcc tcagtgttca      360

ttaagcaggg agactgtaga atgaattata atgatgtccc ccagttttta aaggacagtt      420

tgagggatac tgaaaaggca ggagaaacaa ccttaggttg cgtatgaggt gttgcagaaa      480

cggcagagga agggtataaa ttttaaaaat agaaagcttc tagcgttgag caagatgcgg      540

cgttgtcggt gtttgatttc tggagaggga gcctacaggt agcttcctac aggtcgccac      600

gctagttttg ctgacactga aaaagctggg accctctacc ctgcctatta gagcagcagt      660

ggcccgccca ccagccccac cctgcccgcc ttccggagct tatctccgct cgggttccgc      720

ttctccagcc agcttctggc ccggccccgc ctaccggcct ggcccctccc accttccggc      780

tccacccccc cccccccccc caggctcgca gcctggcccc acctctggac ttccccaatc      840

ctctgtcgcc ctcgccattg gtctctggct ggccgcctgg cccaatcgca gcacttagcg      900

ccagaatttg aaccgccgtt ttggtttgaa tcgggcgggc tgcggcgggc gagccttggc      960

gcggaaccgc ctaggcggac agtcggggct ggacggggcg gcgggtggcg ggtggcgggc     1020

acttgggacg cgggcggcgg gagtgcgggt ctggtcgggg cggagcgaag gccgcgggtg     1080

gccgtggtcg gtcctccgcg gctaaggagc cgagggctcc gacgcgggct gcgcccggtg     1140

agcggcggcc agagctaact tgcgctgact ggaccagctg aggagcggcc cggcggggcg     1200

actgcgagct tcaccgagag gcttctccgc cctggtccgc agtcccgacg gccgggcgga     1260

cccgcggatc caccatggat gctaagtcac tgactgcctg gtcccggaca ctggtgacct     1320

tcaaggatgt gtttgtggac ttcaccaggg aggagtggaa gctgctggac actgctcagc     1380

agatcctgta cagaaatgtg atgctggaga actataagaa cctggtttcc ttgggttatc     1440

agcttactaa gccagatgtg atcctccggt tggagaaggg agaagagccc tggctggtgg     1500

agagagaaat tcaccaagag acccatcctg attcagagac tgcatttgaa atcaaatcat     1560

cagttggcag cggcgcatgc atgtacaaca tgatggagac ggagctgaag ccgccgggcc     1620

cgcagcaaac ttcggggggc ggcggcggca actccaccgc ggcggcggcc ggcggcaacc     1680

agaaaaacag cccggaccgc gtcaagcggc ccatgaatgc cttcatggtg tggtcccgcg     1740

ggcagcggcg caagatggcc caggagaacc ccaagatgca caactcggag atcagcaagc     1800

gcctgggcgc cgagtggaaa cttttgtcgg agacggagaa gcggccgttc atcgacgagg     1860

ctaagcggct gcgagcgctg cacatgaagg agcacccgga ttataaatac cggccccggc     1920

ggaaaaccaa gacgctcatg aagaaggata agtacacgct gcccggcggg ctgctggccc     1980

ccggcggcaa tagcatggcg agcggggtcg gggtgggcgc cggcctgggc gcgggcgtga     2040

accagcgcat ggacagttac gcgcacatga acggctggag caacggcagc tacagcatga     2100

tgcaggacca gctgggcgct agcggcagcg gcaaccatga tcaagagttc gatcctccta     2160

aagtgtatcc ccctgtccct gccgaaaagc ggaaaccgat cagggttctc agtctcttcg     2220

atggaattgc cacaggcctc ttggtcctta aggacctggg catccaagtg gaccgctaca     2280

tcgcctcaga agtatgtgag gacagcatca cagtcggcat ggtgcgccac caggggaaaa     2340

taatgtacgt cggcgacgtc agatcagtta ctcagaaaca tattcaggaa tgggggcctt     2400

ttgatctcgt aattggcggc agcccctgca atgatctgag tattgtgaac cccgcccgga     2460

aaggtttgta cgaaggtacg ggcagactgt tcttcgagtt ttacagactg ttgcacgacg     2520

cacgaccaaa ggagggtgac gatcgaccct tcttctggct gttcgagaac gtggtcgcta     2580

tgggcgtgtc tgacaagcgg gacatttcta gattcctgga gagcaatcca gtgatgattg     2640

atgcaaagga agtatccgct gcccaccgcg ccagatactt ctggggcaat ctgcccggca     2700

tgaatcgacc cttggcaagc accgtgaatg ataagttgga gttgcaggag tgtctggagc     2760

atgggcggat cgcaaagttt agcaaggtgc ggaccatcac gacccgaagc aattcaatta     2820

agcagggaaa ggaccaacat tttccagtgt ttatgaacga gaaagaggac atcctgtggt     2880

gcacagaaat ggagcgggtt ttcggattcc ccgtacatta tactgatgtg tccaatatgt     2940

ctaggttggc tagacagagg ctgttgggac gctcatggag tgttcctgtc atccgccacc     3000

tgttcgctcc tctgaaggag tatttcgcct gcgtttcatc cgggaattca aacgcaaaca     3060

gcagaggccc atccttttct tccggcctgg tgccacttag tctgcgcggc tctcacatgg     3120

gacctatgga aatatacaaa acagtgagcg cctggaagag gcagcctgtg cgggtcctga     3180

gtctgttcag aaacattgac aaggtgctta agtcccttgg atttctggag tctggcagcg     3240

gttctggggg tggcaccctt aagtatgtgg aggacgtgac aaacgtcgtg aggagagatg     3300

tggagaaatg ggggccattt gacctggtat acgggagcac tcaacctctc ggttcttctt     3360

gtgatcgctg cccagggtgg tatatgtttc agttccatcg catcctgcaa tacgcccttc     3420

cgcggcagga gagtcagcga ccattcttct ggatattcat ggacaatctc ctgctgacag     3480

aggacgacca agagactacg actagatttc ttcagaccga ggccgttact ctccaggacg     3540

ttagaggtag ggactaccag aatgccatgc gagtgtggag taacatcccc ggactcaagt     3600

caaagcacgc acccctgacc cccaaggaag aggaatacct ccaggcgcag gtgaggagcc     3660

gcagtaagct cgatgctcct aaagtcgatt tgttggtgaa gaattgcttg ctgcccctga     3720

gagagtactt taagtacttt agccagaaca gcttgccact gggcgcgccc ggtaagccta     3780

tccctaaccc tctcctcggt ctcgattcta cgtga                                3815


<210>  122
<211>  2107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct Ef1a::CS-hSOX21-179 [SESv2]

<400>  122
cgataagctt tgcaaagatg gataaagttt taaacagaga ggaatctttg cagctaatgg       60

accttctagg tcttgaaagg agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc      120

acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag      180

agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc      240

gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac      300

gggtttgccg ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt      360

acgggttatg gcccttgcgt gccttgaatt acttccactg gctgcagtac gtgattcttg      420

atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc      480

cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct      540

ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt      600

gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc      660

tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc      720

gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt      780

ctcaagctgg ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct      840

gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg      900

gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt      960

cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg     1020

agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt     1080

taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg     1140

aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg     1200

gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg     1260

tgtcgtgagg aattctgcag tcgatcgacg gtaccgcggg cccaacggat ccaccatgct     1320

ggaaccagaa aagatcattg gggcaacaga ttcctgtggt gatttaatgt tcctaatgaa     1380

atggaaagac acagatgaag ctgacctggt tcttgcaaaa gaagctaatg tgaaatgtcc     1440

acaaattgtg atagcatttt atgaagagag actgacatgg catgcatatc ctgaggcatg     1500

catgtacaac atgatggaga cggagctgaa gccgccgggc ccgcagcaaa cttcgggggg     1560

cggcggcggc aactccaccg cggcggcggc cggcggcaac cagaaaaaca gcccggaccg     1620

cgtcaagcgg cccatgaatg ccttcatggt gtggtcccgc gggcagcggc gcaagatggc     1680

ccaggagaac cccaagatgc acaactcgga gatcagcaag cgcctgggcg ccgagtggaa     1740

acttttgtcg gagacggaga agcggccgtt catcgacgag gctaagcggc tgcgagcgct     1800

gcacatgaag gagcacccgg attataaata ccggccccgg cggaaaacca agacgctcat     1860

gaagaaggat aagtacacgc tgcccggcgg gctgctggcc cccggcggca atagcatggc     1920

gagcggggtc ggggtgggcg ccggcctggg cgcgggcgtg aaccagcgca tggacagtta     1980

cgcgcacatg aacggctgga gcaacggcag ctacagcatg atgcaggacc agctgggcgc     2040

tagcggcagc ggcggcgcgc ccggtaagcc tatccctaac cctctcctcg gtctcgattc     2100

tacgtga                                                               2107


<210>  123
<211>  2086
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct Ef1a::SOX21-179-Y-R [SESv3]

<400>  123
cgataagctt tgcaaagatg gataaagttt taaacagaga ggaatctttg cagctaatgg       60

accttctagg tcttgaaagg agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc      120

acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag      180

agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc      240

gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac      300

gggtttgccg ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt      360

acgggttatg gcccttgcgt gccttgaatt acttccactg gctgcagtac gtgattcttg      420

atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc      480

cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct      540

ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt      600

gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc      660

tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc      720

gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt      780

ctcaagctgg ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct      840

gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg      900

gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt      960

cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg     1020

agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt     1080

taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg     1140

aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg     1200

gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg     1260

tgtcgtgagg aattctgcag tcgatcgacg gtaccgcggg cccaacggat ccaccatgta     1320

caacatgatg gagacggagc tgaagccgcc gggcccgcag caaacttcgg ggggcggcgg     1380

cggcaactcc accgcggcgg cggccggcgg caaccagaaa aacagcccgg accgcgtcaa     1440

gcggcccatg aatgccttca tggtgtggtc ccgcgggcag cggcgcaaga tggcccagga     1500

gaaccccaag atgcacaact cggagatcag caagcgcctg ggcgccgagt ggaaactttt     1560

gtcggagacg gagaagcggc cgttcatcga cgaggctaag cggctgcgag cgctgcacat     1620

gaaggagcac ccggattata aataccggcc ccggcggaaa accaagacgc tcatgaagaa     1680

ggataagtac acgctgcccg gcgggctgct ggcccccggc ggcaatagca tggcgagcgg     1740

ggtcggggtg ggcgccggcc tgggcgcggg cgtgaaccag cgcatggaca gttacgcgca     1800

catgaacggc tggagcaacg gcagctacag catgatgcag gaccagctgg gcgctagcgg     1860

atccaacatg aggccccggc tgaaaaacgt ggacaggagc actgcacagc agttggcagt     1920

aactgtgggc aacgtcaccg tcattatcac agactttaag gaaaagactc gctcctcatc     1980

gacatcctca tccacagtga cctccagtgc agggtcagaa cagcagaacc agggcgcgcc     2040

cggtaagcct atccctaacc ctctcctcgg tctcgattct acgtga                    2086


<210>  124
<211>  3817
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct Ef1a::KRAB-hTEAD1-166- DNMT3a3L-V5 [TES]

<400>  124
cgataagctt tgcaaagatg gataaagttt taaacagaga ggaatctttg cagctaatgg       60

accttctagg tcttgaaagg agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc      120

acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag      180

agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc      240

gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac      300

gggtttgccg ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt      360

acgggttatg gcccttgcgt gccttgaatt acttccactg gctgcagtac gtgattcttg      420

atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc      480

cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct      540

ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt      600

gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc      660

tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc      720

gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt      780

ctcaagctgg ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct      840

gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg      900

gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt      960

cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg     1020

agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt     1080

taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg     1140

aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg     1200

gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg     1260

tgtcgtgagg aattctgcag tcgatcgacg gtaccgcggg cccaacggat ccaccatgga     1320

tgctaagtca ctgactgcct ggtcccggac actggtgacc ttcaaggatg tgtttgtgga     1380

cttcaccagg gaggagtgga agctgctgga cactgctcag cagatcctgt acagaaatgt     1440

gatgctggag aactataaga acctggtttc cttgggttat cagcttacta agccagatgt     1500

gatcctccgg ttggagaagg gagaagagcc ctggctggtg gagagagaaa ttcaccaaga     1560

gacccatcct gattcagaga ctgcatttga aatcaaatca tcagttggca gcggcgcatg     1620

cattgagccc agcagctgga gcggcagtga gagccctgcc gaaaacatgg aaaggatgag     1680

tgactctgca gataagccaa ttgacaatga tgcagaaggg gtctggagcc ccgacatcga     1740

gcaaagcttt caggaggccc tggctatcta tccaccatgt gggaggagga aaatcatctt     1800

atcagacgaa ggcaaaatgt atggtaggaa tgaattgata gccagataca tcaaactcag     1860

gacaggcaag acgaggacca gaaaacaggt gtctagtcac attcaggttc ttgccagaag     1920

gaaatctcgt gattttcatt ccaagctaaa ggatcagact gcaaaggata aggccctgca     1980

gcacatggcg gccatgtcct cagcccagat cgtctcggcc actgccattc ataacaagct     2040

ggggctgcct gggattccac gcccgacctt cccaggggcg ccggggttct ggccgggaat     2100

gattcaaaca gggcagccag ctagcggcag cggcaaccat gatcaagagt tcgatcctcc     2160

taaagtgtat ccccctgtcc ctgccgaaaa gcggaaaccg atcagggttc tcagtctctt     2220

cgatggaatt gccacaggcc tcttggtcct taaggacctg ggcatccaag tggaccgcta     2280

catcgcctca gaagtatgtg aggacagcat cacagtcggc atggtgcgcc accaggggaa     2340

aataatgtac gtcggcgacg tcagatcagt tactcagaaa catattcagg aatgggggcc     2400

ttttgatctc gtaattggcg gcagcccctg caatgatctg agtattgtga accccgcccg     2460

gaaaggtttg tacgaaggta cgggcagact gttcttcgag ttttacagac tgttgcacga     2520

cgcacgacca aaggagggtg acgatcgacc cttcttctgg ctgttcgaga acgtggtcgc     2580

tatgggcgtg tctgacaagc gggacatttc tagattcctg gagagcaatc cagtgatgat     2640

tgatgcaaag gaagtatccg ctgcccaccg cgccagatac ttctggggca atctgcccgg     2700

catgaatcga cccttggcaa gcaccgtgaa tgataagttg gagttgcagg agtgtctgga     2760

gcatgggcgg atcgcaaagt ttagcaaggt gcggaccatc acgacccgaa gcaattcaat     2820

taagcaggga aaggaccaac attttccagt gtttatgaac gagaaagagg acatcctgtg     2880

gtgcacagaa atggagcggg ttttcggatt ccccgtacat tatactgatg tgtccaatat     2940

gtctaggttg gctagacaga ggctgttggg acgctcatgg agtgttcctg tcatccgcca     3000

cctgttcgct cctctgaagg agtatttcgc ctgcgtttca tccgggaatt caaacgcaaa     3060

cagcagaggc ccatcctttt cttccggcct ggtgccactt agtctgcgcg gctctcacat     3120

gggacctatg gaaatataca aaacagtgag cgcctggaag aggcagcctg tgcgggtcct     3180

gagtctgttc agaaacattg acaaggtgct taagtccctt ggatttctgg agtctggcag     3240

cggttctggg ggtggcaccc ttaagtatgt ggaggacgtg acaaacgtcg tgaggagaga     3300

tgtggagaaa tgggggccat ttgacctggt atacgggagc actcaacctc tcggttcttc     3360

ttgtgatcgc tgcccagggt ggtatatgtt tcagttccat cgcatcctgc aatacgccct     3420

tccgcggcag gagagtcagc gaccattctt ctggatattc atggacaatc tcctgctgac     3480

agaggacgac caagagacta cgactagatt tcttcagacc gaggccgtta ctctccagga     3540

cgttagaggt agggactacc agaatgccat gcgagtgtgg agtaacatcc ccggactcaa     3600

gtcaaagcac gcacccctga cccccaagga agaggaatac ctccaggcgc aggtgaggag     3660

ccgcagtaag ctcgatgctc ctaaagtcga tttgttggtg aagaattgct tgctgcccct     3720

gagagagtac tttaagtact ttagccagaa cagcttgcca ctgggcgcgc ccggtaagcc     3780

tatccctaac cctctcctcg gtctcgattc tacgtga                              3817


<210>  125
<211>  4261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct Ef1a::KRAB-DNMT3a3L-hMYC144-454-V5 [MES]

<400>  125
cgataagctt tgcaaagatg gataaagttt taaacagaga ggaatctttg cagctaatgg       60

accttctagg tcttgaaagg agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc      120

acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag      180

agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc      240

gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac      300

gggtttgccg ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt      360

acgggttatg gcccttgcgt gccttgaatt acttccactg gctgcagtac gtgattcttg      420

atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc      480

cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct      540

ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt      600

gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc      660

tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc      720

gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt      780

ctcaagctgg ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct      840

gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg      900

gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt      960

cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg     1020

agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt     1080

taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg     1140

aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg     1200

gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg     1260

tgtcgtgagg aattctgcag tcgatcgacg gtaccgcggg cccaacggat ccaccatgga     1320

tgctaagtca ctgactgcct ggtcccggac actggtgacc ttcaaggatg tgtttgtgga     1380

cttcaccagg gaggagtgga agctgctgga cactgctcag cagatcctgt acagaaatgt     1440

gatgctggag aactataaga acctggtttc cttgggttat cagcttacta agccagatgt     1500

gatcctccgg ttggagaagg gagaagagcc ctggctggtg gagagagaaa ttcaccaaga     1560

gacccatcct gattcagaga ctgcatttga aatcaaatca tcagttgcta gcggcagcgg     1620

caaccatgat caagagttcg atcctcctaa agtgtatccc cctgtccctg ccgaaaagcg     1680

gaaaccgatc agggttctca gtctcttcga tggaattgcc acaggcctct tggtccttaa     1740

ggacctgggc atccaagtgg accgctacat cgcctcagaa gtatgtgagg acagcatcac     1800

agtcggcatg gtgcgccacc aggggaaaat aatgtacgtc ggcgacgtca gatcagttac     1860

tcagaaacat attcaggaat gggggccttt tgatctcgta attggcggca gcccctgcaa     1920

tgatctgagt attgtgaacc ccgcccggaa aggtttgtac gaaggtacgg gcagactgtt     1980

cttcgagttt tacagactgt tgcacgacgc acgaccaaag gagggtgacg atcgaccctt     2040

cttctggctg ttcgagaacg tggtcgctat gggcgtgtct gacaagcggg acatttctag     2100

attcctggag agcaatccag tgatgattga tgcaaaggaa gtatccgctg cccaccgcgc     2160

cagatacttc tggggcaatc tgcccggcat gaatcgaccc ttggcaagca ccgtgaatga     2220

taagttggag ttgcaggagt gtctggagca tgggcggatc gcaaagttta gcaaggtgcg     2280

gaccatcacg acccgaagca attcaattaa gcagggaaag gaccaacatt ttccagtgtt     2340

tatgaacgag aaagaggaca tcctgtggtg cacagaaatg gagcgggttt tcggattccc     2400

cgtacattat actgatgtgt ccaatatgtc taggttggct agacagaggc tgttgggacg     2460

ctcatggagt gttcctgtca tccgccacct gttcgctcct ctgaaggagt atttcgcctg     2520

cgtttcatcc gggaattcaa acgcaaacag cagaggccca tccttttctt ccggcctggt     2580

gccacttagt ctgcgcggct ctcacatggg acctatggaa atatacaaaa cagtgagcgc     2640

ctggaagagg cagcctgtgc gggtcctgag tctgttcaga aacattgaca aggtgcttaa     2700

gtcccttgga tttctggagt ctggcagcgg ttctgggggt ggcaccctta agtatgtgga     2760

ggacgtgaca aacgtcgtga ggagagatgt ggagaaatgg gggccatttg acctggtata     2820

cgggagcact caacctctcg gttcttcttg tgatcgctgc ccagggtggt atatgtttca     2880

gttccatcgc atcctgcaat acgcccttcc gcggcaggag agtcagcgac cattcttctg     2940

gatattcatg gacaatctcc tgctgacaga ggacgaccaa gagactacga ctagatttct     3000

tcagaccgag gccgttactc tccaggacgt tagaggtagg gactaccaga atgccatgcg     3060

agtgtggagt aacatccccg gactcaagtc aaagcacgca cccctgaccc ccaaggaaga     3120

ggaatacctc caggcgcagg tgaggagccg cagtaagctc gatgctccta aagtcgattt     3180

gttggtgaag aattgcttgc tgcccctgag agagtacttt aagtacttta gccagaacag     3240

cttgccactg ggcgcgcccg ccgctgccat catccaggac tgtatgtgga gcggcttctc     3300

ggccgccgcc aagctcgtct cagagaagct ggcctcctac caggctgcgc gcaaagacag     3360

cggcagcccg aaccccgccc gcggccacag cgtctgctcc acctccagct tgtacctgca     3420

ggatctgagc gccgccgcct cagagtgcat cgacccctcg gtggtcttcc cctaccctct     3480

caacgacagc agctcgccca agtcctgcgc ctcgcaagac tccagcgcct tctctccgtc     3540

ctcggattct ctgctctcct cgacggagtc ctccccgcag ggcagccccg agcccctggt     3600

gctccatgag gagacaccgc ccaccaccag cagcgactct gaggaggaac aagaagatga     3660

ggaagaaatc gatgttgttt ctgtggaaaa gaggcaggct cctggcaaaa ggtcagagtc     3720

tggatcacct tctgctggag gccacagcaa acctcctcac agcccactgg tcctcaagag     3780

gtgccacgtc tccacacatc agcacaacta cgcagcgcct ccctccactc ggaaggacta     3840

tcctgctgcc aagagggtca agttggacag tgtcagagtc ctgagacaga tcagcaacaa     3900

ccgaaaatgc accagcccca ggtcctcgga caccgaggag aatgtcaaga ggcgaacaca     3960

caacgtcttg gagcgccaga ggaggaacga gctaaaacgg agcttttttg ccctgcgtga     4020

ccagatcccg gagttggaaa acaatgaaaa ggcccccaag gtagttatcc ttaaaaaagc     4080

cacagcatac atcctgtccg tccaagcaga ggagcaaaag ctcatttctg aagaggactt     4140

gttgcggaaa cgacgagaac agttgaaaca caaacttgaa cagctacgga actcttgtgc     4200

ggctagcggc gcgcccggta agcctatccc taaccctctc ctcggtctcg attctacgtg     4260

a                                                                     4261


