                         SEQUENCE LISTING

<110>  OBI Pharma, Inc.
       LAI, MING-TAIN
 
<120>  GLOBO SERIES ANTIGENS-BINDING CHIMERIC ANTIGEN RECEPTORS AND USES
        THEREOF

<130>  OBIP-4PCT

<150>  63/147237
<151>  2021-02-09

<150>  63/147441
<151>  2021-02-09

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C2 Heavy Chain (HC)

<400>  1

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Gln Val Thr Leu Lys Glu Ser Gly Pro Gly 
            20                  25                  30          


Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly 
        35                  40                  45              


Phe Ser Leu Tyr Thr Phe Asp Met Gly Val Gly Trp Ile Arg Gln Pro 
    50                  55                  60                  


Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp 
65                  70                  75                  80  


Lys Tyr Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Val Ser Lys Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Val Phe Leu Lys Ile Pro Asn Val Asp Thr Ala 
            100                 105                 110         


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Val Arg Gly Leu His Asp Tyr 
        115                 120                 125             


Tyr Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val 
            


<210>  2
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C2 Light Chain (LC)

<400>  2

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Gln Ile Val Leu Ser Gln Ser Pro Thr Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Phe Cys Gln Gln Trp 
            100                 105                 110         


Ser Arg Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys Arg Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  3
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C2 scFv

<400>  3

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Leu Pro Gly Ala Lys Cys Gln Val Thr Leu Lys 
            20                  25                  30          


Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr 
        35                  40                  45              


Cys Ser Phe Ser Gly Phe Ser Leu Tyr Thr Phe Asp Met Gly Val Gly 
    50                  55                  60                  


Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile 
65                  70                  75                  80  


Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Lys Ser Arg Leu 
                85                  90                  95      


Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val Phe Leu Lys Ile Pro 
            100                 105                 110         


Asn Val Asp Thr Ala Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Val Arg 
        115                 120                 125             


Gly Leu His Asp Tyr Tyr Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu 
                165                 170                 175     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
            180                 185                 190         


Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
        195                 200                 205             


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
225                 230                 235                 240 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Phe Cys Gln Gln Trp Ser 
                245                 250                 255     


Arg Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            260                 265                 270         


<210>  4
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R783 Heavy Chain (HC)

<400>  4

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Thr Leu Gln Glu Ser Gly Pro Thr Leu Val 
            20                  25                  30          


Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser 
        35                  40                  45              


Leu Tyr Arg Phe Asp Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr 
65                  70                  75                  80  


Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Arg Val Arg Gly Leu His Asp Tyr Tyr Tyr 
        115                 120                 125             


Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val 
    


<210>  5
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R783 Light Chain (LC)

<400>  5

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Gln Ala Ser Glu Asp 
        35                  40                  45              


Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Gln 
    50                  55                  60                  


Pro Trp Ile Tyr Gly Thr Ser Asn Lys Ala Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg 
            100                 105                 110         


Arg Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  6
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R783 scFv

<400>  6

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Thr Leu Gln Glu Ser Gly Pro Thr Leu Val 
            20                  25                  30          


Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser 
        35                  40                  45              


Leu Tyr Arg Phe Asp Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr 
65                  70                  75                  80  


Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Arg Val Arg Gly Leu His Asp Tyr Tyr Tyr 
        115                 120                 125             


Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Gln Ala Ser Glu Asp Val Ser Tyr Met His Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Gln Pro Trp Ile Tyr Gly Thr 
        195                 200                 205             


Ser Asn Lys Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Arg Pro Phe Thr Phe Gly 
                245                 250                 255     


Gln Gly Thr Lys Val Glu Ile Lys Arg 
            260                 265 


<210>  7
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 Hinge

<400>  7

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  8
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane & costimulatory domain

<400>  8

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  9
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB costimulatory domain

<400>  9

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  10
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zeta domain

<400>  10

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg 
        


<210>  11
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zeta mutant (CD3zm) domain

<400>  11

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg 
        


<210>  12
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A linker

<400>  12

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  13
<211>  768
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C2-Fab CAR

<400>  13

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Gln Val Thr Leu Lys Glu Ser Gly Pro Gly 
            20                  25                  30          


Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly 
        35                  40                  45              


Phe Ser Leu Tyr Thr Phe Asp Met Gly Val Gly Trp Ile Arg Gln Pro 
    50                  55                  60                  


Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp 
65                  70                  75                  80  


Lys Tyr Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Val Ser Lys Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Val Phe Leu Lys Ile Pro Asn Val Asp Thr Ala 
            100                 105                 110         


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Val Arg Gly Leu His Asp Tyr 
        115                 120                 125             


Tyr Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    450                 455                 460                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
465                 470                 475                 480 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                485                 490                 495     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510         


Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
        515                 520                 525             


Glu Asn Pro Gly Pro Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly 
    530                 535                 540                 


Leu Leu Leu Leu Trp Leu Pro Gly Ala Lys Cys Gln Ile Val Leu Ser 
545                 550                 555                 560 


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
                565                 570                 575     


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
            580                 585                 590         


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
        595                 600                 605             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    610                 615                 620                 


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
625                 630                 635                 640 


Phe Cys Gln Gln Trp Ser Arg Asn Pro Phe Thr Phe Gly Gln Gly Thr 
                645                 650                 655     


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
            660                 665                 670         


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
        675                 680                 685             


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
    690                 695                 700                 


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
705                 710                 715                 720 


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
                725                 730                 735     


Lys Ala Asp Tyr Glu Lys Arg Lys Val Tyr Ala Cys Glu Val Thr His 
            740                 745                 750         


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        755                 760                 765             


<210>  14
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C2-scFv CAR

<400>  14

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Leu Pro Gly Ala Lys Cys Gln Val Thr Leu Lys 
            20                  25                  30          


Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr 
        35                  40                  45              


Cys Ser Phe Ser Gly Phe Ser Leu Tyr Thr Phe Asp Met Gly Val Gly 
    50                  55                  60                  


Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile 
65                  70                  75                  80  


Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Lys Ser Arg Leu 
                85                  90                  95      


Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val Phe Leu Lys Ile Pro 
            100                 105                 110         


Asn Val Asp Thr Ala Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Val Arg 
        115                 120                 125             


Gly Leu His Asp Tyr Tyr Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu 
                165                 170                 175     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
            180                 185                 190         


Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
        195                 200                 205             


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
225                 230                 235                 240 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Phe Cys Gln Gln Trp Ser 
                245                 250                 255     


Arg Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val 
305                 310                 315                 320 


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
                325                 330                 335     


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
            340                 345                 350         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        355                 360                 365             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    370                 375                 380                 


Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
385                 390                 395                 400 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                405                 410                 415     


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Arg Val Lys Phe 
            420                 425                 430         


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        435                 440                 445             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    450                 455                 460                 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
465                 470                 475                 480 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                485                 490                 495     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            500                 505                 510         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        515                 520                 525             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 540     


<210>  15
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R783-Fab CAR

<400>  15

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Thr Leu Gln Glu Ser Gly Pro Thr Leu Val 
            20                  25                  30          


Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser 
        35                  40                  45              


Leu Tyr Arg Phe Asp Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr 
65                  70                  75                  80  


Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Arg Val Arg Gly Leu His Asp Tyr Tyr Tyr 
        115                 120                 125             


Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                245                 250                 255     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            260                 265                 270         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
305                 310                 315                 320 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                325                 330                 335     


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            340                 345                 350         


Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        355                 360                 365             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    370                 375                 380                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
            500                 505                 510         


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
        515                 520                 525             


Pro Gly Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu 
    530                 535                 540                 


Trp Val Pro Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ser 
545                 550                 555                 560 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Gln Ala 
                565                 570                 575     


Ser Glu Asp Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln 
            580                 585                 590         


Ala Pro Gln Pro Trp Ile Tyr Gly Thr Ser Asn Lys Ala Ser Gly Val 
        595                 600                 605             


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    610                 615                 620                 


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
625                 630                 635                 640 


Trp Ser Arg Arg Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
                645                 650                 655     


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
            660                 665                 670         


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
        675                 680                 685             


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
    690                 695                 700                 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
705                 710                 715                 720 


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
                725                 730                 735     


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
            740                 745                 750         


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        755                 760                 


<210>  16
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R783-scFv CAR

<400>  16

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Thr Leu Gln Glu Ser Gly Pro Thr Leu Val 
            20                  25                  30          


Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser 
        35                  40                  45              


Leu Tyr Arg Phe Asp Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr 
65                  70                  75                  80  


Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Arg Val Arg Gly Leu His Asp Tyr Tyr Tyr 
        115                 120                 125             


Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Gln Ala Ser Glu Asp Val Ser Tyr Met His Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Gln Pro Trp Ile Tyr Gly Thr 
        195                 200                 205             


Ser Asn Lys Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Arg Pro Phe Thr Phe Gly 
                245                 250                 255     


Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val 
305                 310                 315                 320 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                325                 330                 335     


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            340                 345                 350         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        355                 360                 365             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys 
    370                 375                 380                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
385                 390                 395                 400 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                405                 410                 415     


Gly Cys Glu Leu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            420                 425                 430         


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        435                 440                 445             


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    450                 455                 460                 


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
465                 470                 475                 480 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                485                 490                 495     


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            500                 505                 510         


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        515                 520                 525             


Gln Ala Leu Pro Pro Arg 
    530                 


<210>  17
<211>  768
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C2-Fab CAR (CD3zm)

<400>  17

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys Gln Val Thr Leu Lys Glu Ser Gly Pro Gly 
            20                  25                  30          


Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly 
        35                  40                  45              


Phe Ser Leu Tyr Thr Phe Asp Met Gly Val Gly Trp Ile Arg Gln Pro 
    50                  55                  60                  


Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp 
65                  70                  75                  80  


Lys Tyr Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Val Ser Lys Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Val Phe Leu Lys Ile Pro Asn Val Asp Thr Ala 
            100                 105                 110         


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Val Arg Gly Leu His Asp Tyr 
        115                 120                 125             


Tyr Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys 
    450                 455                 460                 


Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg 
465                 470                 475                 480 


Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala 
                485                 490                 495     


Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510         


Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
        515                 520                 525             


Glu Asn Pro Gly Pro Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly 
    530                 535                 540                 


Leu Leu Leu Leu Trp Leu Pro Gly Ala Lys Cys Gln Ile Val Leu Ser 
545                 550                 555                 560 


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
                565                 570                 575     


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
            580                 585                 590         


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
        595                 600                 605             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    610                 615                 620                 


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
625                 630                 635                 640 


Phe Cys Gln Gln Trp Ser Arg Asn Pro Phe Thr Phe Gly Gln Gly Thr 
                645                 650                 655     


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
            660                 665                 670         


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
        675                 680                 685             


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
    690                 695                 700                 


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
705                 710                 715                 720 


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
                725                 730                 735     


Lys Ala Asp Tyr Glu Lys Arg Lys Val Tyr Ala Cys Glu Val Thr His 
            740                 745                 750         


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        755                 760                 765             


<210>  18
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R783-scFv CAR (CD3zm)

<400>  18

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Thr Leu Gln Glu Ser Gly Pro Thr Leu Val 
            20                  25                  30          


Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser 
        35                  40                  45              


Leu Tyr Arg Phe Asp Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr 
65                  70                  75                  80  


Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Arg Val Arg Gly Leu His Asp Tyr Tyr Tyr 
        115                 120                 125             


Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Ser Cys Gln Ala Ser Glu Asp Val Ser Tyr Met His Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Gln Pro Trp Ile Tyr Gly Thr 
        195                 200                 205             


Ser Asn Lys Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Arg Pro Phe Thr Phe Gly 
                245                 250                 255     


Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val 
305                 310                 315                 320 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                325                 330                 335     


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            340                 345                 350         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        355                 360                 365             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys 
    370                 375                 380                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
385                 390                 395                 400 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                405                 410                 415     


Gly Cys Glu Leu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
            420                 425                 430         


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        435                 440                 445             


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
    450                 455                 460                 


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
465                 470                 475                 480 


Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile 
                485                 490                 495     


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe 
            500                 505                 510         


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met 
        515                 520                 525             


Gln Ala Leu Pro Pro Arg 
    530                 


