                         SEQUENCE LISTING

<110>  The University of Manchester
 
<120>  ADAMTS13 Variant

<130>  MEH/119879PCT1

<150>  GB2102208.2
<151>  2021-02-17

<160>  156   

<170>  PatentIn version 3.5

<210>  1
<211>  1427
<212>  PRT
<213>  Homo sapiens

<400>  1

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr 
    1415                 1420                 1425         


<210>  2
<211>  1371
<212>  PRT
<213>  Homo sapiens

<400>  2

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Ala  Cys Gly Arg Gln His  Leu Glu Pro 
    1130                 1135                 1140             


Thr Gly  Thr Ile Asp Met Arg  Gly Pro Gly Gln Ala  Asp Cys Ala 
    1145                 1150                 1155             


Val Ala  Ile Gly Arg Pro Leu  Gly Glu Val Val Thr  Leu Arg Val 
    1160                 1165                 1170             


Leu Glu  Ser Ser Leu Asn Cys  Ser Ala Gly Asp Met  Leu Leu Leu 
    1175                 1180                 1185             


Trp Gly  Arg Leu Thr Trp Arg  Lys Met Cys Arg Lys  Leu Leu Asp 
    1190                 1195                 1200             


Met Thr  Phe Ser Ser Lys Thr  Asn Thr Leu Val Val  Arg Gln Arg 
    1205                 1210                 1215             


Cys Gly  Arg Pro Gly Gly Gly  Val Leu Leu Arg Tyr  Gly Ser Gln 
    1220                 1225                 1230             


Leu Ala  Pro Glu Thr Phe Tyr  Arg Glu Cys Asp Met  Gln Leu Phe 
    1235                 1240                 1245             


Gly Pro  Trp Gly Glu Ile Val  Ser Pro Ser Leu Ser  Pro Ala Thr 
    1250                 1255                 1260             


Ser Asn  Ala Gly Gly Cys Arg  Leu Phe Ile Asn Val  Ala Pro His 
    1265                 1270                 1275             


Ala Arg  Ile Ala Ile His Ala  Leu Ala Thr Asn Met  Gly Ala Gly 
    1280                 1285                 1290             


Thr Glu  Gly Ala Asn Ala Ser  Tyr Ile Leu Ile Arg  Asp Thr His 
    1295                 1300                 1305             


Ser Leu  Arg Thr Thr Ala Phe  His Gly Gln Gln Val  Leu Tyr Trp 
    1310                 1315                 1320             


Glu Ser  Glu Ser Ser Gln Ala  Glu Met Glu Phe Ser  Glu Gly Phe 
    1325                 1330                 1335             


Leu Lys  Ala Gln Ala Ser Leu  Arg Gly Gln Tyr Trp  Thr Leu Gln 
    1340                 1345                 1350             


Ser Trp  Val Pro Glu Met Gln  Asp Pro Gln Ser Trp  Lys Gly Lys 
    1355                 1360                 1365             


Glu Gly  Thr 
    1370     


<210>  3
<211>  1340
<212>  PRT
<213>  Homo sapiens

<400>  3

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala 
        275                 280                 285             


Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu 
    290                 295                 300                 


Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu 
305                 310                 315                 320 


Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser 
                325                 330                 335     


Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val 
            340                 345                 350         


His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser 
        355                 360                 365             


Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg 
    370                 375                 380                 


Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu 
385                 390                 395                 400 


Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser 
                405                 410                 415     


Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly 
            420                 425                 430         


Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly 
        435                 440                 445             


Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile 
    450                 455                 460                 


Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser 
465                 470                 475                 480 


Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys 
                485                 490                 495     


Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp 
            500                 505                 510         


Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys 
        515                 520                 525             


Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr 
    530                 535                 540                 


Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu 
545                 550                 555                 560 


Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly 
                565                 570                 575     


Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp 
            580                 585                 590         


Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg 
        595                 600                 605             


Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile 
    610                 615                 620                 


Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro 
625                 630                 635                 640 


Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val 
                645                 650                 655     


Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu 
            660                 665                 670         


Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val 
        675                 680                 685             


Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu 
    690                 695                 700                 


Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe 
705                 710                 715                 720 


Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val 
                725                 730                 735     


Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala 
            740                 745                 750         


Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys 
        755                 760                 765             


Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser 
    770                 775                 780                 


Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys 
785                 790                 795                 800 


Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly 
                805                 810                 815     


Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser 
            820                 825                 830         


Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys 
        835                 840                 845             


Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His 
    850                 855                 860                 


Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly 
865                 870                 875                 880 


Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro 
                885                 890                 895     


Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg 
            900                 905                 910         


Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu 
        915                 920                 925             


Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu 
    930                 935                 940                 


Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu 
945                 950                 955                 960 


Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu Pro Gln Glu Ala Cys 
                965                 970                 975     


Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val Met Ser Leu Gly Pro 
            980                 985                 990         


Cys Ser Ala Ser Cys Gly Leu Gly  Thr Ala Arg Arg Ser  Val Ala Cys 
        995                 1000                 1005             


Val Gln  Leu Asp Gln Gly Gln  Asp Val Glu Val Asp  Glu Ala Ala 
    1010                 1015                 1020             


Cys Ala  Ala Leu Val Arg Pro  Glu Ala Ser Val Pro  Cys Leu Ile 
    1025                 1030                 1035             


Ala Asp  Cys Thr Tyr Arg Trp  His Val Gly Thr Trp  Met Glu Cys 
    1040                 1045                 1050             


Ser Val  Ser Cys Gly Asp Gly  Ile Gln Arg Arg Arg  Asp Thr Cys 
    1055                 1060                 1065             


Leu Gly  Pro Gln Ala Gln Ala  Pro Val Pro Ala Asp  Phe Cys Gln 
    1070                 1075                 1080             


His Leu  Pro Lys Pro Val Thr  Val Arg Gly Cys Trp  Ala Gly Pro 
    1085                 1090                 1095             


Cys Val  Gly Gln Gly Ala Cys  Gly Arg Gln His Leu  Glu Pro Thr 
    1100                 1105                 1110             


Gly Thr  Ile Asp Met Arg Gly  Pro Gly Gln Ala Asp  Cys Ala Val 
    1115                 1120                 1125             


Ala Ile  Gly Arg Pro Leu Gly  Glu Val Val Thr Leu  Arg Val Leu 
    1130                 1135                 1140             


Glu Ser  Ser Leu Asn Cys Ser  Ala Gly Asp Met Leu  Leu Leu Trp 
    1145                 1150                 1155             


Gly Arg  Leu Thr Trp Arg Lys  Met Cys Arg Lys Leu  Leu Asp Met 
    1160                 1165                 1170             


Thr Phe  Ser Ser Lys Thr Asn  Thr Leu Val Val Arg  Gln Arg Cys 
    1175                 1180                 1185             


Gly Arg  Pro Gly Gly Gly Val  Leu Leu Arg Tyr Gly  Ser Gln Leu 
    1190                 1195                 1200             


Ala Pro  Glu Thr Phe Tyr Arg  Glu Cys Asp Met Gln  Leu Phe Gly 
    1205                 1210                 1215             


Pro Trp  Gly Glu Ile Val Ser  Pro Ser Leu Ser Pro  Ala Thr Ser 
    1220                 1225                 1230             


Asn Ala  Gly Gly Cys Arg Leu  Phe Ile Asn Val Ala  Pro His Ala 
    1235                 1240                 1245             


Arg Ile  Ala Ile His Ala Leu  Ala Thr Asn Met Gly  Ala Gly Thr 
    1250                 1255                 1260             


Glu Gly  Ala Asn Ala Ser Tyr  Ile Leu Ile Arg Asp  Thr His Ser 
    1265                 1270                 1275             


Leu Arg  Thr Thr Ala Phe His  Gly Gln Gln Val Leu  Tyr Trp Glu 
    1280                 1285                 1290             


Ser Glu  Ser Ser Gln Ala Glu  Met Glu Phe Ser Glu  Gly Phe Leu 
    1295                 1300                 1305             


Lys Ala  Gln Ala Ser Leu Arg  Gly Gln Tyr Trp Thr  Leu Gln Ser 
    1310                 1315                 1320             


Trp Val  Pro Glu Met Gln Asp  Pro Gln Ser Trp Lys  Gly Lys Glu 
    1325                 1330                 1335             


Gly Thr  
    1340 


<210>  4
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln 
1               5                   10                  15      


Ser Ser Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys 
            20                  25                  30          


Gly Val Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu 
        35                  40                  45              


Leu Thr Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro 
    50                  55                  60                  


Arg Ser Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg 
65                  70                  75                  80  


Arg Gln Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val 
                85                  90                  95      


Gly Ala Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys 
            100                 105                 110         


Thr Gln Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln 
        115                 120                 125             


Pro Leu Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala 
    130                 135                 140                 


Ala Val Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg 
145                 150                 155                 160 


Ala Ile Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp 
                165                 170                 175     


Gly Thr Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser 
            180                 185                 190         


Leu Cys Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met 
        195                 200                 205             


Asp Ser Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn 
    210                 215                 220                 


Ser Thr Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg 
225                 230                 235                 240 


Glu Tyr Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr 
                245                 250                 255     


Ile Ala Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly 
            260                 265                 270         


Gly Arg Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr 
        275                 280                 285             


Tyr Pro Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu 
    290                 295                 300                 


Thr Glu Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro 
305                 310                 315                 320 


Leu Gln Glu Asp Ala Asp Ile Gln Val Gly Gly Val Arg Ala Gln Leu 
                325                 330                 335     


Met His Ile Ser Trp Trp Ser Arg Pro Gly Leu Gly Glu Arg Asp Leu 
            340                 345                 350         


Cys Ala Arg Gly Arg Trp Pro Gly Gly Ser Ser Asp 
        355                 360                 


<210>  5
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  5

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly 
            20                  25                  


<210>  6
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  6

Pro Ser His Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala 
1               5                   10                  15      


Val Ser Ser Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro 
            20                  25                  30          


Ser Pro Gly Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg 
        35                  40                  45  


<210>  7
<211>  1398
<212>  PRT
<213>  Homo sapiens

<400>  7

Pro Ser His Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala 
1               5                   10                  15      


Val Ser Ser Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro 
            20                  25                  30          


Ser Pro Gly Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly 
        35                  40                  45              


Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe 
    50                  55                  60                  


Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn 
65                  70                  75                  80  


Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg 
                85                  90                  95      


Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro 
            100                 105                 110         


Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp 
        115                 120                 125             


Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp 
    130                 135                 140                 


Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn 
145                 150                 155                 160 


Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr 
                165                 170                 175     


Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr 
            180                 185                 190         


Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala 
        195                 200                 205             


Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly 
    210                 215                 220                 


Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln 
225                 230                 235                 240 


Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro 
                245                 250                 255     


Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro 
            260                 265                 270         


Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro 
        275                 280                 285             


Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln 
    290                 295                 300                 


Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg 
305                 310                 315                 320 


Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp 
                325                 330                 335     


Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala 
            340                 345                 350         


Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser 
        355                 360                 365             


Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn 
    370                 375                 380                 


Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln 
385                 390                 395                 400 


Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe 
                405                 410                 415     


Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser 
            420                 425                 430         


Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser 
        435                 440                 445             


Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser 
    450                 455                 460                 


Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met 
465                 470                 475                 480 


Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly 
                485                 490                 495     


Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val 
            500                 505                 510         


Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro 
        515                 520                 525             


Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe 
    530                 535                 540                 


Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg 
545                 550                 555                 560 


Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val 
                565                 570                 575     


Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu 
            580                 585                 590         


Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu 
        595                 600                 605             


Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala 
    610                 615                 620                 


Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr 
625                 630                 635                 640 


Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala 
                645                 650                 655     


Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala 
            660                 665                 670         


Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu 
        675                 680                 685             


Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp 
    690                 695                 700                 


Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly 
705                 710                 715                 720 


Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg 
                725                 730                 735     


Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro 
            740                 745                 750         


Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu 
        755                 760                 765             


Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro 
    770                 775                 780                 


Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu 
785                 790                 795                 800 


Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly 
                805                 810                 815     


Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly 
            820                 825                 830         


Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly 
        835                 840                 845             


Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala 
    850                 855                 860                 


Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly 
865                 870                 875                 880 


Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg 
                885                 890                 895     


Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser 
            900                 905                 910         


Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr 
        915                 920                 925             


Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg 
    930                 935                 940                 


Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile 
945                 950                 955                 960 


Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu Pro Gln Glu 
                965                 970                 975     


Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val Met Ser Leu 
            980                 985                 990         


Gly Pro Cys Ser Ala Ser Cys Gly  Leu Gly Thr Ala Arg  Arg Ser Val 
        995                 1000                 1005             


Ala Cys  Val Gln Leu Asp Gln  Gly Gln Asp Val Glu  Val Asp Glu 
    1010                 1015                 1020             


Ala Ala  Cys Ala Ala Leu Val  Arg Pro Glu Ala Ser  Val Pro Cys 
    1025                 1030                 1035             


Leu Ile  Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
    1040                 1045                 1050             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1055                 1060                 1065             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1070                 1075                 1080             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1085                 1090                 1095             


Gly Pro  Cys Val Gly Gln Gly  Thr Pro Ser Leu Val  Pro His Glu 
    1100                 1105                 1110             


Glu Ala  Ala Ala Pro Gly Arg  Thr Thr Ala Thr Pro  Ala Gly Ala 
    1115                 1120                 1125             


Ser Leu  Glu Trp Ser Gln Ala  Arg Gly Leu Leu Phe  Ser Pro Ala 
    1130                 1135                 1140             


Pro Gln  Pro Arg Arg Leu Leu  Pro Gly Pro Gln Glu  Asn Ser Val 
    1145                 1150                 1155             


Gln Ser  Ser Ala Cys Gly Arg  Gln His Leu Glu Pro  Thr Gly Thr 
    1160                 1165                 1170             


Ile Asp  Met Arg Gly Pro Gly  Gln Ala Asp Cys Ala  Val Ala Ile 
    1175                 1180                 1185             


Gly Arg  Pro Leu Gly Glu Val  Val Thr Leu Arg Val  Leu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Asn Cys Ser Ala Gly  Asp Met Leu Leu Leu  Trp Gly Arg 
    1205                 1210                 1215             


Leu Thr  Trp Arg Lys Met Cys  Arg Lys Leu Leu Asp  Met Thr Phe 
    1220                 1225                 1230             


Ser Ser  Lys Thr Asn Thr Leu  Val Val Arg Gln Arg  Cys Gly Arg 
    1235                 1240                 1245             


Pro Gly  Gly Gly Val Leu Leu  Arg Tyr Gly Ser Gln  Leu Ala Pro 
    1250                 1255                 1260             


Glu Thr  Phe Tyr Arg Glu Cys  Asp Met Gln Leu Phe  Gly Pro Trp 
    1265                 1270                 1275             


Gly Glu  Ile Val Ser Pro Ser  Leu Ser Pro Ala Thr  Ser Asn Ala 
    1280                 1285                 1290             


Gly Gly  Cys Arg Leu Phe Ile  Asn Val Ala Pro His  Ala Arg Ile 
    1295                 1300                 1305             


Ala Ile  His Ala Leu Ala Thr  Asn Met Gly Ala Gly  Thr Glu Gly 
    1310                 1315                 1320             


Ala Asn  Ala Ser Tyr Ile Leu  Ile Arg Asp Thr His  Ser Leu Arg 
    1325                 1330                 1335             


Thr Thr  Ala Phe His Gly Gln  Gln Val Leu Tyr Trp  Glu Ser Glu 
    1340                 1345                 1350             


Ser Ser  Gln Ala Glu Met Glu  Phe Ser Glu Gly Phe  Leu Lys Ala 
    1355                 1360                 1365             


Gln Ala  Ser Leu Arg Gly Gln  Tyr Trp Thr Leu Gln  Ser Trp Val 
    1370                 1375                 1380             


Pro Glu  Met Gln Asp Pro Gln  Ser Trp Lys Gly Lys  Glu Gly Thr 
    1385                 1390                 1395             


<210>  8
<211>  1353
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro 
1               5                   10                  15      


Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr 
            20                  25                  30          


Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala 
        35                  40                  45              


Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu 
    50                  55                  60                  


Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val 
65                  70                  75                  80  


Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly 
                85                  90                  95      


His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro 
            100                 105                 110         


Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys 
        115                 120                 125             


Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu 
    130                 135                 140                 


Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His 
145                 150                 155                 160 


Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala 
                165                 170                 175     


Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser 
            180                 185                 190         


Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val 
        195                 200                 205             


Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp 
    210                 215                 220                 


Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala 
225                 230                 235                 240 


Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp 
                245                 250                 255     


Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser 
            260                 265                 270         


Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val 
        275                 280                 285             


Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr 
    290                 295                 300                 


Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser 
305                 310                 315                 320 


Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln 
                325                 330                 335     


Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala 
            340                 345                 350         


Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln 
        355                 360                 365             


Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu 
    370                 375                 380                 


Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val 
385                 390                 395                 400 


Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile 
                405                 410                 415     


Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr 
            420                 425                 430         


Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys 
        435                 440                 445             


Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser 
    450                 455                 460                 


Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr 
465                 470                 475                 480 


Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr 
                485                 490                 495     


Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala 
            500                 505                 510         


Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg 
        515                 520                 525             


Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
    530                 535                 540                 


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu 
545                 550                 555                 560 


Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln 
                565                 570                 575     


Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly 
            580                 585                 590         


Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro 
        595                 600                 605             


Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser 
    610                 615                 620                 


Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala 
625                 630                 635                 640 


Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro 
                645                 650                 655     


Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp 
            660                 665                 670         


Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu 
        675                 680                 685             


Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys 
    690                 695                 700                 


Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val 
705                 710                 715                 720 


Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val 
                725                 730                 735     


Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu 
            740                 745                 750         


Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val 
        755                 760                 765             


Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro 
    770                 775                 780                 


Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr 
785                 790                 795                 800 


Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly 
                805                 810                 815     


Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val 
            820                 825                 830         


Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser 
        835                 840                 845             


Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys 
    850                 855                 860                 


Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg 
865                 870                 875                 880 


Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val 
                885                 890                 895     


Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly 
            900                 905                 910         


Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu 
        915                 920                 925             


Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val 
    930                 935                 940                 


Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg 
945                 950                 955                 960 


Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val 
                965                 970                 975     


Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro 
            980                 985                 990         


Cys Leu Ile Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
        995                 1000                 1005             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1010                 1015                 1020             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1025                 1030                 1035             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1040                 1045                 1050             


Gly Pro  Cys Val Gly Gln Gly  Thr Pro Ser Leu Val  Pro His Glu 
    1055                 1060                 1065             


Glu Ala  Ala Ala Pro Gly Arg  Thr Thr Ala Thr Pro  Ala Gly Ala 
    1070                 1075                 1080             


Ser Leu  Glu Trp Ser Gln Ala  Arg Gly Leu Leu Phe  Ser Pro Ala 
    1085                 1090                 1095             


Pro Gln  Pro Arg Arg Leu Leu  Pro Gly Pro Gln Glu  Asn Ser Val 
    1100                 1105                 1110             


Gln Ser  Ser Ala Cys Gly Arg  Gln His Leu Glu Pro  Thr Gly Thr 
    1115                 1120                 1125             


Ile Asp  Met Arg Gly Pro Gly  Gln Ala Asp Cys Ala  Val Ala Ile 
    1130                 1135                 1140             


Gly Arg  Pro Leu Gly Glu Val  Val Thr Leu Arg Val  Leu Glu Ser 
    1145                 1150                 1155             


Ser Leu  Asn Cys Ser Ala Gly  Asp Met Leu Leu Leu  Trp Gly Arg 
    1160                 1165                 1170             


Leu Thr  Trp Arg Lys Met Cys  Arg Lys Leu Leu Asp  Met Thr Phe 
    1175                 1180                 1185             


Ser Ser  Lys Thr Asn Thr Leu  Val Val Arg Gln Arg  Cys Gly Arg 
    1190                 1195                 1200             


Pro Gly  Gly Gly Val Leu Leu  Arg Tyr Gly Ser Gln  Leu Ala Pro 
    1205                 1210                 1215             


Glu Thr  Phe Tyr Arg Glu Cys  Asp Met Gln Leu Phe  Gly Pro Trp 
    1220                 1225                 1230             


Gly Glu  Ile Val Ser Pro Ser  Leu Ser Pro Ala Thr  Ser Asn Ala 
    1235                 1240                 1245             


Gly Gly  Cys Arg Leu Phe Ile  Asn Val Ala Pro His  Ala Arg Ile 
    1250                 1255                 1260             


Ala Ile  His Ala Leu Ala Thr  Asn Met Gly Ala Gly  Thr Glu Gly 
    1265                 1270                 1275             


Ala Asn  Ala Ser Tyr Ile Leu  Ile Arg Asp Thr His  Ser Leu Arg 
    1280                 1285                 1290             


Thr Thr  Ala Phe His Gly Gln  Gln Val Leu Tyr Trp  Glu Ser Glu 
    1295                 1300                 1305             


Ser Ser  Gln Ala Glu Met Glu  Phe Ser Glu Gly Phe  Leu Lys Ala 
    1310                 1315                 1320             


Gln Ala  Ser Leu Arg Gly Gln  Tyr Trp Thr Leu Gln  Ser Trp Val 
    1325                 1330                 1335             


Pro Glu  Met Gln Asp Pro Gln  Ser Trp Lys Gly Lys  Glu Gly Thr 
    1340                 1345                 1350             


<210>  9
<211>  1342
<212>  PRT
<213>  Homo sapiens

<400>  9

Pro Ser His Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala 
1               5                   10                  15      


Val Ser Ser Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro 
            20                  25                  30          


Ser Pro Gly Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly 
        35                  40                  45              


Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe 
    50                  55                  60                  


Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn 
65                  70                  75                  80  


Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg 
                85                  90                  95      


Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro 
            100                 105                 110         


Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp 
        115                 120                 125             


Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp 
    130                 135                 140                 


Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn 
145                 150                 155                 160 


Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr 
                165                 170                 175     


Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr 
            180                 185                 190         


Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala 
        195                 200                 205             


Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly 
    210                 215                 220                 


Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln 
225                 230                 235                 240 


Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro 
                245                 250                 255     


Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro 
            260                 265                 270         


Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro 
        275                 280                 285             


Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln 
    290                 295                 300                 


Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg 
305                 310                 315                 320 


Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp 
                325                 330                 335     


Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala 
            340                 345                 350         


Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser 
        355                 360                 365             


Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn 
    370                 375                 380                 


Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln 
385                 390                 395                 400 


Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe 
                405                 410                 415     


Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser 
            420                 425                 430         


Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser 
        435                 440                 445             


Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser 
    450                 455                 460                 


Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met 
465                 470                 475                 480 


Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly 
                485                 490                 495     


Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val 
            500                 505                 510         


Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro 
        515                 520                 525             


Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe 
    530                 535                 540                 


Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg 
545                 550                 555                 560 


Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val 
                565                 570                 575     


Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu 
            580                 585                 590         


Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu 
        595                 600                 605             


Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala 
    610                 615                 620                 


Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr 
625                 630                 635                 640 


Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala 
                645                 650                 655     


Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala 
            660                 665                 670         


Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu 
        675                 680                 685             


Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp 
    690                 695                 700                 


Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly 
705                 710                 715                 720 


Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg 
                725                 730                 735     


Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro 
            740                 745                 750         


Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu 
        755                 760                 765             


Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro 
    770                 775                 780                 


Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu 
785                 790                 795                 800 


Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly 
                805                 810                 815     


Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly 
            820                 825                 830         


Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly 
        835                 840                 845             


Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala 
    850                 855                 860                 


Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly 
865                 870                 875                 880 


Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg 
                885                 890                 895     


Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser 
            900                 905                 910         


Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr 
        915                 920                 925             


Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg 
    930                 935                 940                 


Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile 
945                 950                 955                 960 


Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu Pro Gln Glu 
                965                 970                 975     


Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val Met Ser Leu 
            980                 985                 990         


Gly Pro Cys Ser Ala Ser Cys Gly  Leu Gly Thr Ala Arg  Arg Ser Val 
        995                 1000                 1005             


Ala Cys  Val Gln Leu Asp Gln  Gly Gln Asp Val Glu  Val Asp Glu 
    1010                 1015                 1020             


Ala Ala  Cys Ala Ala Leu Val  Arg Pro Glu Ala Ser  Val Pro Cys 
    1025                 1030                 1035             


Leu Ile  Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
    1040                 1045                 1050             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1055                 1060                 1065             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1070                 1075                 1080             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1085                 1090                 1095             


Gly Pro  Cys Val Gly Gln Gly  Ala Cys Gly Arg Gln  His Leu Glu 
    1100                 1105                 1110             


Pro Thr  Gly Thr Ile Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys 
    1115                 1120                 1125             


Ala Val  Ala Ile Gly Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg 
    1130                 1135                 1140             


Val Leu  Glu Ser Ser Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu 
    1145                 1150                 1155             


Leu Trp  Gly Arg Leu Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu 
    1160                 1165                 1170             


Asp Met  Thr Phe Ser Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln 
    1175                 1180                 1185             


Arg Cys  Gly Arg Pro Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser 
    1190                 1195                 1200             


Gln Leu  Ala Pro Glu Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu 
    1205                 1210                 1215             


Phe Gly  Pro Trp Gly Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala 
    1220                 1225                 1230             


Thr Ser  Asn Ala Gly Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro 
    1235                 1240                 1245             


His Ala  Arg Ile Ala Ile His  Ala Leu Ala Thr Asn  Met Gly Ala 
    1250                 1255                 1260             


Gly Thr  Glu Gly Ala Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr 
    1265                 1270                 1275             


His Ser  Leu Arg Thr Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr 
    1280                 1285                 1290             


Trp Glu  Ser Glu Ser Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly 
    1295                 1300                 1305             


Phe Leu  Lys Ala Gln Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu 
    1310                 1315                 1320             


Gln Ser  Trp Val Pro Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly 
    1325                 1330                 1335             


Lys Glu  Gly Thr 
    1340         


<210>  10
<211>  1297
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro 
1               5                   10                  15      


Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr 
            20                  25                  30          


Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala 
        35                  40                  45              


Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu 
    50                  55                  60                  


Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val 
65                  70                  75                  80  


Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly 
                85                  90                  95      


His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro 
            100                 105                 110         


Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys 
        115                 120                 125             


Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu 
    130                 135                 140                 


Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His 
145                 150                 155                 160 


Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala 
                165                 170                 175     


Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser 
            180                 185                 190         


Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val 
        195                 200                 205             


Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp 
    210                 215                 220                 


Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala 
225                 230                 235                 240 


Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp 
                245                 250                 255     


Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser 
            260                 265                 270         


Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val 
        275                 280                 285             


Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr 
    290                 295                 300                 


Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser 
305                 310                 315                 320 


Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln 
                325                 330                 335     


Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala 
            340                 345                 350         


Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln 
        355                 360                 365             


Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu 
    370                 375                 380                 


Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val 
385                 390                 395                 400 


Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile 
                405                 410                 415     


Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr 
            420                 425                 430         


Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys 
        435                 440                 445             


Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser 
    450                 455                 460                 


Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr 
465                 470                 475                 480 


Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr 
                485                 490                 495     


Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala 
            500                 505                 510         


Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg 
        515                 520                 525             


Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
    530                 535                 540                 


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu 
545                 550                 555                 560 


Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln 
                565                 570                 575     


Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly 
            580                 585                 590         


Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro 
        595                 600                 605             


Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser 
    610                 615                 620                 


Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala 
625                 630                 635                 640 


Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro 
                645                 650                 655     


Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp 
            660                 665                 670         


Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu 
        675                 680                 685             


Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys 
    690                 695                 700                 


Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val 
705                 710                 715                 720 


Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val 
                725                 730                 735     


Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu 
            740                 745                 750         


Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val 
        755                 760                 765             


Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro 
    770                 775                 780                 


Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr 
785                 790                 795                 800 


Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly 
                805                 810                 815     


Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val 
            820                 825                 830         


Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser 
        835                 840                 845             


Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys 
    850                 855                 860                 


Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg 
865                 870                 875                 880 


Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val 
                885                 890                 895     


Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly 
            900                 905                 910         


Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu 
        915                 920                 925             


Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val 
    930                 935                 940                 


Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg 
945                 950                 955                 960 


Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val 
                965                 970                 975     


Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro 
            980                 985                 990         


Cys Leu Ile Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
        995                 1000                 1005             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1010                 1015                 1020             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1025                 1030                 1035             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1040                 1045                 1050             


Gly Pro  Cys Val Gly Gln Gly  Ala Cys Gly Arg Gln  His Leu Glu 
    1055                 1060                 1065             


Pro Thr  Gly Thr Ile Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys 
    1070                 1075                 1080             


Ala Val  Ala Ile Gly Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg 
    1085                 1090                 1095             


Val Leu  Glu Ser Ser Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu 
    1100                 1105                 1110             


Leu Trp  Gly Arg Leu Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu 
    1115                 1120                 1125             


Asp Met  Thr Phe Ser Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln 
    1130                 1135                 1140             


Arg Cys  Gly Arg Pro Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser 
    1145                 1150                 1155             


Gln Leu  Ala Pro Glu Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu 
    1160                 1165                 1170             


Phe Gly  Pro Trp Gly Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala 
    1175                 1180                 1185             


Thr Ser  Asn Ala Gly Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro 
    1190                 1195                 1200             


His Ala  Arg Ile Ala Ile His  Ala Leu Ala Thr Asn  Met Gly Ala 
    1205                 1210                 1215             


Gly Thr  Glu Gly Ala Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr 
    1220                 1225                 1230             


His Ser  Leu Arg Thr Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr 
    1235                 1240                 1245             


Trp Glu  Ser Glu Ser Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly 
    1250                 1255                 1260             


Phe Leu  Lys Ala Gln Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu 
    1265                 1270                 1275             


Gln Ser  Trp Val Pro Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly 
    1280                 1285                 1290             


Lys Glu  Gly Thr 
    1295         


<210>  11
<211>  1311
<212>  PRT
<213>  Homo sapiens

<400>  11

Pro Ser His Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala 
1               5                   10                  15      


Val Ser Ser Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro 
            20                  25                  30          


Ser Pro Gly Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly 
        35                  40                  45              


Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe 
    50                  55                  60                  


Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn 
65                  70                  75                  80  


Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg 
                85                  90                  95      


Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro 
            100                 105                 110         


Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp 
        115                 120                 125             


Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp 
    130                 135                 140                 


Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn 
145                 150                 155                 160 


Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr 
                165                 170                 175     


Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr 
            180                 185                 190         


Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala 
        195                 200                 205             


Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly 
    210                 215                 220                 


Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln 
225                 230                 235                 240 


Leu Leu Ser Leu Leu Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly 
                245                 250                 255     


Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys 
            260                 265                 270         


Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser 
        275                 280                 285             


Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys 
    290                 295                 300                 


Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile 
305                 310                 315                 320 


Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys 
                325                 330                 335     


Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn 
            340                 345                 350         


Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu 
        355                 360                 365             


Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu 
    370                 375                 380                 


Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser 
385                 390                 395                 400 


Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His 
                405                 410                 415     


Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu 
            420                 425                 430         


Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys 
        435                 440                 445             


Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser 
    450                 455                 460                 


Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln 
465                 470                 475                 480 


Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser 
                485                 490                 495     


Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr 
            500                 505                 510         


Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His 
        515                 520                 525             


Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val 
    530                 535                 540                 


Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu 
545                 550                 555                 560 


Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg 
                565                 570                 575     


Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp 
            580                 585                 590         


Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu 
        595                 600                 605             


Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln 
    610                 615                 620                 


Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly 
625                 630                 635                 640 


Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys 
                645                 650                 655     


Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala 
            660                 665                 670         


Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val 
        675                 680                 685             


Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu 
    690                 695                 700                 


Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu 
705                 710                 715                 720 


Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu 
                725                 730                 735     


Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu 
            740                 745                 750         


Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn 
        755                 760                 765             


Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu 
    770                 775                 780                 


Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val 
785                 790                 795                 800 


Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala 
                805                 810                 815     


Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln 
            820                 825                 830         


Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys 
        835                 840                 845             


Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu 
    850                 855                 860                 


Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly 
865                 870                 875                 880 


Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln 
                885                 890                 895     


Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg 
            900                 905                 910         


Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu 
        915                 920                 925             


Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu Pro Gln 
    930                 935                 940                 


Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val Met Ser 
945                 950                 955                 960 


Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg Arg Ser 
                965                 970                 975     


Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val Asp Glu 
            980                 985                 990         


Ala Ala Cys Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
        995                 1000                 1005             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1010                 1015                 1020             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1025                 1030                 1035             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1040                 1045                 1050             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1055                 1060                 1065             


Pro Cys  Val Gly Gln Gly Ala  Cys Gly Arg Gln His  Leu Glu Pro 
    1070                 1075                 1080             


Thr Gly  Thr Ile Asp Met Arg  Gly Pro Gly Gln Ala  Asp Cys Ala 
    1085                 1090                 1095             


Val Ala  Ile Gly Arg Pro Leu  Gly Glu Val Val Thr  Leu Arg Val 
    1100                 1105                 1110             


Leu Glu  Ser Ser Leu Asn Cys  Ser Ala Gly Asp Met  Leu Leu Leu 
    1115                 1120                 1125             


Trp Gly  Arg Leu Thr Trp Arg  Lys Met Cys Arg Lys  Leu Leu Asp 
    1130                 1135                 1140             


Met Thr  Phe Ser Ser Lys Thr  Asn Thr Leu Val Val  Arg Gln Arg 
    1145                 1150                 1155             


Cys Gly  Arg Pro Gly Gly Gly  Val Leu Leu Arg Tyr  Gly Ser Gln 
    1160                 1165                 1170             


Leu Ala  Pro Glu Thr Phe Tyr  Arg Glu Cys Asp Met  Gln Leu Phe 
    1175                 1180                 1185             


Gly Pro  Trp Gly Glu Ile Val  Ser Pro Ser Leu Ser  Pro Ala Thr 
    1190                 1195                 1200             


Ser Asn  Ala Gly Gly Cys Arg  Leu Phe Ile Asn Val  Ala Pro His 
    1205                 1210                 1215             


Ala Arg  Ile Ala Ile His Ala  Leu Ala Thr Asn Met  Gly Ala Gly 
    1220                 1225                 1230             


Thr Glu  Gly Ala Asn Ala Ser  Tyr Ile Leu Ile Arg  Asp Thr His 
    1235                 1240                 1245             


Ser Leu  Arg Thr Thr Ala Phe  His Gly Gln Gln Val  Leu Tyr Trp 
    1250                 1255                 1260             


Glu Ser  Glu Ser Ser Gln Ala  Glu Met Glu Phe Ser  Glu Gly Phe 
    1265                 1270                 1275             


Leu Lys  Ala Gln Ala Ser Leu  Arg Gly Gln Tyr Trp  Thr Leu Gln 
    1280                 1285                 1290             


Ser Trp  Val Pro Glu Met Gln  Asp Pro Gln Ser Trp  Lys Gly Lys 
    1295                 1300                 1305             


Glu Gly  Thr 
    1310     


<210>  12
<211>  1266
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro 
1               5                   10                  15      


Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr 
            20                  25                  30          


Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala 
        35                  40                  45              


Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu 
    50                  55                  60                  


Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val 
65                  70                  75                  80  


Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly 
                85                  90                  95      


His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro 
            100                 105                 110         


Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys 
        115                 120                 125             


Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu 
    130                 135                 140                 


Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His 
145                 150                 155                 160 


Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala 
                165                 170                 175     


Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser 
            180                 185                 190         


Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Asn Glu Gln Cys Arg Val 
        195                 200                 205             


Ala Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu 
    210                 215                 220                 


Asp Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser 
225                 230                 235                 240 


Ser Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly 
                245                 250                 255     


Val Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu 
            260                 265                 270         


Thr Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg 
        275                 280                 285             


Ser Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg 
    290                 295                 300                 


Gln Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly 
305                 310                 315                 320 


Ala Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr 
                325                 330                 335     


Gln Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro 
            340                 345                 350         


Leu Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala 
        355                 360                 365             


Val Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala 
    370                 375                 380                 


Ile Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly 
385                 390                 395                 400 


Thr Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu 
                405                 410                 415     


Cys Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp 
            420                 425                 430         


Ser Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser 
        435                 440                 445             


Thr Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu 
    450                 455                 460                 


Tyr Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile 
465                 470                 475                 480 


Ala Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly 
                485                 490                 495     


Arg Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr 
            500                 505                 510         


Pro Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr 
        515                 520                 525             


Glu Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu 
    530                 535                 540                 


Gln Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr 
545                 550                 555                 560 


Gly Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys 
                565                 570                 575     


Pro Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val 
            580                 585                 590         


Ser Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln 
        595                 600                 605             


Ala Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln 
    610                 615                 620                 


Pro Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr 
625                 630                 635                 640 


Trp Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly 
                645                 650                 655     


Leu Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu 
            660                 665                 670         


Lys Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala 
        675                 680                 685             


Val Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu 
    690                 695                 700                 


Val Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala 
705                 710                 715                 720 


Leu Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro 
                725                 730                 735     


Val Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu 
            740                 745                 750         


Pro Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala 
        755                 760                 765             


Thr Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr 
    770                 775                 780                 


Gly Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser 
785                 790                 795                 800 


Val Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp 
                805                 810                 815     


Ser Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser 
            820                 825                 830         


Lys Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala 
        835                 840                 845             


Arg Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly 
    850                 855                 860                 


Val Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp 
865                 870                 875                 880 


Gly Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro 
                885                 890                 895     


Glu Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys 
            900                 905                 910         


Val Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala 
        915                 920                 925             


Arg Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu 
    930                 935                 940                 


Val Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val 
945                 950                 955                 960 


Pro Cys Leu Ile Ala Asp Cys Thr Tyr Arg Trp His Val Gly Thr Trp 
                965                 970                 975     


Met Glu Cys Ser Val Ser Cys Gly Asp Gly Ile Gln Arg Arg Arg Asp 
            980                 985                 990         


Thr Cys Leu Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
        995                 1000                 1005             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1010                 1015                 1020             


Pro Cys  Val Gly Gln Gly Ala  Cys Gly Arg Gln His  Leu Glu Pro 
    1025                 1030                 1035             


Thr Gly  Thr Ile Asp Met Arg  Gly Pro Gly Gln Ala  Asp Cys Ala 
    1040                 1045                 1050             


Val Ala  Ile Gly Arg Pro Leu  Gly Glu Val Val Thr  Leu Arg Val 
    1055                 1060                 1065             


Leu Glu  Ser Ser Leu Asn Cys  Ser Ala Gly Asp Met  Leu Leu Leu 
    1070                 1075                 1080             


Trp Gly  Arg Leu Thr Trp Arg  Lys Met Cys Arg Lys  Leu Leu Asp 
    1085                 1090                 1095             


Met Thr  Phe Ser Ser Lys Thr  Asn Thr Leu Val Val  Arg Gln Arg 
    1100                 1105                 1110             


Cys Gly  Arg Pro Gly Gly Gly  Val Leu Leu Arg Tyr  Gly Ser Gln 
    1115                 1120                 1125             


Leu Ala  Pro Glu Thr Phe Tyr  Arg Glu Cys Asp Met  Gln Leu Phe 
    1130                 1135                 1140             


Gly Pro  Trp Gly Glu Ile Val  Ser Pro Ser Leu Ser  Pro Ala Thr 
    1145                 1150                 1155             


Ser Asn  Ala Gly Gly Cys Arg  Leu Phe Ile Asn Val  Ala Pro His 
    1160                 1165                 1170             


Ala Arg  Ile Ala Ile His Ala  Leu Ala Thr Asn Met  Gly Ala Gly 
    1175                 1180                 1185             


Thr Glu  Gly Ala Asn Ala Ser  Tyr Ile Leu Ile Arg  Asp Thr His 
    1190                 1195                 1200             


Ser Leu  Arg Thr Thr Ala Phe  His Gly Gln Gln Val  Leu Tyr Trp 
    1205                 1210                 1215             


Glu Ser  Glu Ser Ser Gln Ala  Glu Met Glu Phe Ser  Glu Gly Phe 
    1220                 1225                 1230             


Leu Lys  Ala Gln Ala Ser Leu  Arg Gly Gln Tyr Trp  Thr Leu Gln 
    1235                 1240                 1245             


Ser Trp  Val Pro Glu Met Gln  Asp Pro Gln Ser Trp  Lys Gly Lys 
    1250                 1255                 1260             


Glu Gly  Thr 
    1265     


<210>  13
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala 
1               5                   10                  15      


His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly 
            20                  25                  30          


Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His 
        35                  40                  45              


Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile 
    50                  55                  60                  


Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln 
65                  70                  75                  80  


Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val 
                85                  90                  95      


Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln 
            100                 105                 110         


Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser 
        115                 120                 125             


Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala 
    130                 135                 140                 


His Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly 
145                 150                 155                 160 


Ser Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala 
                165                 170                 175     


Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu 
            180                 185                 190         


Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro 
        195                 200                 205         


<210>  14
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  14

Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly 
1               5                   10                  15      


Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys 
            20                  25                  30          


Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala 
        35                  40                  45              


Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu 
    50                  55                  60                  


Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys 
65                  70                  75                  80  


Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala 
                85                  90                  95      


Val 
    


<210>  15
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  15

His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser 
1               5                   10                  15      


Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg 
            20                  25                  30          


Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu 
        35                  40                  45              


Met Cys Asn Thr Gln Ala Cys Glu 
    50                  55      


<210>  16
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  16

Lys Thr Gln Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly 
1               5                   10                  15      


Gln Pro Leu Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly 
            20                  25                  30          


Ala Ala Val Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys 
        35                  40                  45              


Arg Ala Ile Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu 
    50                  55                  60                  


Asp Gly Thr Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu 
65                  70                  75                  80  


Ser Leu Cys Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg 
                85                  90                  95      


Met Asp Ser Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp 
            100                 105                 110         


Asn Ser Thr Cys Ser 
        115         


<210>  17
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  17

Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val 
1               5                   10                  15      


Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn 
            20                  25                  30          


His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr 
        35                  40                  45              


Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser 
    50                  55                  60                  


Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp 
65                  70                  75                  80  


Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu 
                85                  90                  95      


Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn 
            100                 105                 110         


Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg 
        115                 120                 125             


Gln Ala 
    130 


<210>  18
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  18

Pro Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val 
1               5                   10                  15      


Ser Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln 
            20                  25                  30          


Ala Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln 
        35                  40                  45              


Pro 
    


<210>  19
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  19

Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser 
1               5                   10                  15      


Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln 
            20                  25                  30          


Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala 
        35                  40                  45              


Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro 
    50                  55                  60                  


<210>  20
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  20

Trp Glu Val Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly 
1               5                   10                  15      


Leu Ala Leu Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu 
            20                  25                  30          


Ala Pro Val Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala 
        35                  40                  45              


Pro Glu Pro Cys 
    50          


<210>  21
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  21

Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly 
1               5                   10                  15      


Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro 
            20                  25                  30          


Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg 
        35                  40                  45              


Glu Val Cys Gln Ala Val Pro 
    50                  55  


<210>  22
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  22

Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys 
1               5                   10                  15      


Gly Arg Gly Val Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly 
            20                  25                  30          


Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu 
        35                  40                  45              


Pro Arg Pro Glu Pro Gln Glu Ala Cys Ser Leu Glu Pro 
    50                  55                  60      


<210>  23
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  23

Cys Pro Pro Arg Trp Lys Val Met Ser Leu Gly Pro Cys Ser Ala Ser 
1               5                   10                  15      


Cys Gly Leu Gly Thr Ala Arg Arg Ser Val Ala Cys Val Gln Leu Asp 
            20                  25                  30          


Gln Gly Gln Asp Val Glu Val Asp Glu Ala Ala Cys Ala Ala Leu Val 
        35                  40                  45              


Arg Pro Glu Ala Ser Val Pro Cys Leu 
    50                  55          


<210>  24
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  24

Cys Thr Tyr Arg Trp His Val Gly Thr Trp Met Glu Cys Ser Val Ser 
1               5                   10                  15      


Cys Gly Asp Gly Ile Gln Arg Arg Arg Asp Thr Cys Leu Gly Pro Gln 
            20                  25                  30          


Ala Gln Ala Pro Val Pro Ala Asp Phe Cys Gln His Leu Pro Lys Pro 
        35                  40                  45              


Val Thr Val Arg Gly Cys Trp Ala Gly Pro Cys Val 
    50                  55                  60  


<210>  25
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  25

Cys Gly Arg Gln His Leu Glu Pro Thr Gly Thr Ile Asp Met Arg Gly 
1               5                   10                  15      


Pro Gly Gln Ala Asp Cys Ala Val Ala Ile Gly Arg Pro Leu Gly Glu 
            20                  25                  30          


Val Val Thr Leu Arg Val Leu Glu Ser Ser Leu Asn Cys Ser Ala Gly 
        35                  40                  45              


Asp Met Leu Leu Leu Trp Gly Arg Leu Thr Trp Arg Lys Met Cys Arg 
    50                  55                  60                  


Lys Leu Leu Asp Met Thr Phe Ser Ser Lys Thr Asn Thr Leu Val Val 
65                  70                  75                  80  


Arg Gln Arg Cys Gly Arg Pro Gly Gly Gly Val Leu Leu Arg Tyr Gly 
                85                  90                  95      


Ser Gln Leu Ala Pro Glu Thr Phe Tyr Arg Glu 
            100                 105         


<210>  26
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  26

Cys Asp Met Gln Leu Phe Gly Pro Trp Gly Glu Ile Val Ser Pro Ser 
1               5                   10                  15      


Leu Ser Pro Ala Thr Ser Asn Ala Gly Gly Cys Arg Leu Phe Ile Asn 
            20                  25                  30          


Val Ala Pro His Ala Arg Ile Ala Ile His Ala Leu Ala Thr Asn Met 
        35                  40                  45              


Gly Ala Gly Thr Glu Gly Ala Asn Ala Ser Tyr Ile Leu Ile Arg Asp 
    50                  55                  60                  


Thr His Ser Leu Arg Thr Thr Ala Phe His Gly Gln Gln Val Leu Tyr 
65                  70                  75                  80  


Trp Glu Ser Glu Ser Ser Gln Ala Glu Met Glu Phe Ser Glu Gly Phe 
                85                  90                  95      


Leu Lys Ala Gln Ala Ser Leu Arg Gly Gln Tyr Trp Thr Leu Gln Ser 
            100                 105                 110         


Trp Val Pro Glu Met Gln Asp Pro Gln Ser Trp Lys Gly Lys Glu Gly 
        115                 120                 125             


Thr 
    


<210>  27
<211>  2813
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Gln Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Thr Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro Asp Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asp  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Arg Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Met Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Thr Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  28
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Ala Gln Asp Glu Glu Glu Gly Ile Gln Asp Leu Asp Gly Leu 
1               5                   10                  15      


Leu Val Phe Asp Lys Ile Val Glu Val Thr Leu Leu Asn Leu Pro Trp 
            20                  25                  30          


Tyr Asn Glu Glu Thr Glu Gly Gln Arg Gly Glu Met Thr Ala Pro Lys 
        35                  40                  45              


Ser Pro Arg Ala Lys Ile Arg Gly Thr Leu Cys Ala Glu Gly Thr Arg 
    50                  55                  60                  


Gly Arg Ser Ser Thr Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val 
65                  70                  75                  80  


Asn Thr Phe Asp Gly Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr 
                85                  90                  95      


Leu Leu Ala Gly Gly Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp 
            100                 105                 110         


Phe Gln Asn Gly Lys Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe 
        115                 120                 125             


Phe Asp Ile His Leu Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln 
    130                 135                 140                 


Arg Val Ser Met Pro Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu 
145                 150                 155                 160 


Ala Gly Tyr Tyr Lys Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg 
                165                 170                 175     


Ile Asp Gly Ser Gly Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe 
            180                 185                 190         


Asn Lys Thr Cys Gly Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp 
        195                 200                 205             


Asp Phe Met Thr Gln Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe 
    210                 215                 220                 


Ala Asn Ser Trp Ala Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala 
225                 230                 235                 240 


Ser Pro Pro Ser Ser Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys 
                245                 250                 255     


Glu Glu Pro Glu Cys Asn Asp Ile Thr Ala Arg Leu Gln Tyr Val Lys 
            260                 265                 270         


Val Gly Ser Cys Lys Ser Glu Val Glu Val Asp Ile His Tyr Cys Gln 
        275                 280                 285             


Gly Lys Cys Ala Ser Lys Ala Met Tyr Ser Ile Asp Ile Asn Asp Val 
    290                 295                 300                 


Gln Asp Gln Cys Ser Cys Cys Ser Pro Thr Arg Thr Glu Pro Met Gln 
305                 310                 315                 320 


Val Ala Leu His Cys Thr Asn Gly Ser Val Val Tyr His Glu Val Leu 
                325                 330                 335     


Asn Ala Met Glu Cys Lys Cys Ser Pro Arg Lys Cys Ser Lys Ile 
            340                 345                 350     


<210>  29
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys 
            20          


<210>  30
<211>  2791
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr Ala Arg Cys Ser Leu Phe 
1               5                   10                  15      


Gly Ser Asp Phe Val Asn Thr Phe Asp Gly Ser Met Tyr Ser Phe Ala 
            20                  25                  30          


Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly Cys Gln Lys Arg Ser Phe 
        35                  40                  45              


Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys Arg Val Ser Leu Ser Val 
    50                  55                  60                  


Tyr Leu Gly Glu Phe Phe Asp Ile His Leu Phe Val Asn Gly Thr Val 
65                  70                  75                  80  


Thr Gln Gly Asp Gln Arg Val Ser Met Pro Tyr Ala Ser Lys Gly Leu 
                85                  90                  95      


Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys Leu Ser Gly Glu Ala Tyr 
            100                 105                 110         


Gly Phe Val Ala Arg Ile Asp Gly Ser Gly Asn Phe Gln Val Leu Leu 
        115                 120                 125             


Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly Leu Cys Gly Asn Phe Asn 
    130                 135                 140                 


Ile Phe Ala Glu Asp Asp Phe Met Thr Gln Glu Gly Thr Leu Thr Ser 
145                 150                 155                 160 


Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala Leu Ser Ser Gly Glu Gln 
                165                 170                 175     


Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser Ser Cys Asn Ile Ser Ser 
            180                 185                 190         


Gly Glu Met Gln Lys Gly Leu Trp Glu Gln Cys Gln Leu Leu Lys Ser 
        195                 200                 205             


Thr Ser Val Phe Ala Arg Cys His Pro Leu Val Asp Pro Glu Pro Phe 
    210                 215                 220                 


Val Ala Leu Cys Glu Lys Thr Leu Cys Glu Cys Ala Gly Gly Leu Glu 
225                 230                 235                 240 


Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala Arg Thr Cys Ala Gln Glu 
                245                 250                 255     


Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser Ala Cys Ser Pro Val 
            260                 265                 270         


Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser Pro Cys Ala Arg 
        275                 280                 285             


Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln Glu Arg Cys Val 
    290                 295                 300                 


Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp Glu Gly Leu Cys 
305                 310                 315                 320 


Val Glu Ser Thr Glu Cys Pro Cys Val His Ser Gly Lys Arg Tyr Pro 
                325                 330                 335     


Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn Thr Cys Ile Cys Arg Asn 
            340                 345                 350         


Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys Pro Gly Glu Cys Leu Val 
        355                 360                 365             


Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg Tyr Phe Thr Phe 
    370                 375                 380                 


Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys Gln Asp His Ser 
385                 390                 395                 400 


Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp Asp Arg Asp Ala 
                405                 410                 415     


Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly Leu His Asn Ser 
            420                 425                 430         


Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met Asp Gly Gln Asp 
        435                 440                 445             


Val Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile Gln His Thr Val 
    450                 455                 460                 


Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu Gln Met Asp Trp 
465                 470                 475                 480 


Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro Val Tyr Ala Gly 
                485                 490                 495     


Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn Gln Gly Asp Asp 
            500                 505                 510         


Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro Arg Val Glu Asp Phe Gly 
        515                 520                 525             


Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu Gln Lys Gln His 
    530                 535                 540                 


Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg Phe Ser Glu Glu 
545                 550                 555                 560 


Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala Cys His Arg Ala 
                565                 570                 575     


Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg Tyr Asp Val Cys Ser 
            580                 585                 590         


Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly Ala Leu Ala Ser Tyr Ala 
        595                 600                 605             


Ala Ala Cys Ala Gly Arg Gly Val Arg Val Ala Trp Arg Glu Pro Gly 
    610                 615                 620                 


Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln Val Tyr Leu Gln Cys Gly 
625                 630                 635                 640 


Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser Tyr Pro Asp Glu Glu 
                645                 650                 655     


Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe Cys Pro Pro Gly Leu Tyr 
            660                 665                 670         


Met Asp Glu Arg Gly Asp Cys Val Pro Lys Ala Gln Cys Pro Cys Tyr 
        675                 680                 685             


Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile Phe Ser Asp His His 
    690                 695                 700                 


Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His Cys Thr Met Ser Gly 
705                 710                 715                 720 


Val Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser Pro Leu Ser 
                725                 730                 735     


His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu 
            740                 745                 750         


Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys 
        755                 760                 765             


Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser 
    770                 775                 780                 


Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg Cys Val 
785                 790                 795                 800 


Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro 
                805                 810                 815     


Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Gln Asp Arg 
            820                 825                 830         


Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile 
        835                 840                 845             


Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro 
    850                 855                 860                 


Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro 
865                 870                 875                 880 


Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser 
                885                 890                 895     


Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile 
            900                 905                 910         


Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu 
        915                 920                 925             


Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu 
    930                 935                 940                 


Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile Ser Val 
945                 950                 955                 960 


Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn 
                965                 970                 975     


Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val 
            980                 985                 990         


Glu Glu Asp Pro Val Asp Phe Gly  Asn Ser Trp Lys Val  Ser Ser Gln 
        995                 1000                 1005             


Cys Ala  Asp Thr Arg Lys Val  Pro Leu Asp Ser Ser  Pro Ala Thr 
    1010                 1015                 1020             


Cys His  Asn Asn Ile Met Lys  Gln Thr Met Val Asp  Ser Ser Cys 
    1025                 1030                 1035             


Arg Ile  Leu Thr Ser Asp Val  Phe Gln Asp Cys Asn  Lys Leu Val 
    1040                 1045                 1050             


Asp Pro  Glu Pro Tyr Leu Asp  Val Cys Ile Tyr Asp  Thr Cys Ser 
    1055                 1060                 1065             


Cys Glu  Ser Ile Gly Asp Cys  Ala Cys Phe Cys Asp  Thr Ile Ala 
    1070                 1075                 1080             


Ala Tyr  Ala His Val Cys Ala  Gln His Gly Lys Val  Val Thr Trp 
    1085                 1090                 1095             


Arg Thr  Ala Thr Leu Cys Pro  Gln Ser Cys Glu Glu  Arg Asn Leu 
    1100                 1105                 1110             


Arg Glu  Asn Gly Tyr Glu Cys  Glu Trp Arg Tyr Asn  Ser Cys Ala 
    1115                 1120                 1125             


Pro Ala  Cys Gln Val Thr Cys  Gln His Pro Glu Pro  Leu Ala Cys 
    1130                 1135                 1140             


Pro Val  Gln Cys Val Glu Gly  Cys His Ala His Cys  Pro Pro Gly 
    1145                 1150                 1155             


Lys Ile  Leu Asp Glu Leu Leu  Gln Thr Cys Val Asp  Pro Glu Asp 
    1160                 1165                 1170             


Cys Pro  Val Cys Glu Val Ala  Gly Arg Arg Phe Ala  Ser Gly Lys 
    1175                 1180                 1185             


Lys Val  Thr Leu Asn Pro Ser  Asp Pro Glu His Cys  Gln Ile Cys 
    1190                 1195                 1200             


His Cys  Asp Val Val Asn Leu  Thr Cys Glu Ala Cys  Gln Glu Pro 
    1205                 1210                 1215             


Gly Gly  Leu Val Val Pro Pro  Thr Asp Ala Pro Val  Ser Pro Thr 
    1220                 1225                 1230             


Thr Leu  Tyr Val Glu Asp Ile  Ser Glu Pro Pro Leu  His Asp Phe 
    1235                 1240                 1245             


Tyr Cys  Ser Arg Leu Leu Asp  Leu Val Phe Leu Leu  Asp Gly Ser 
    1250                 1255                 1260             


Ser Arg  Leu Ser Glu Ala Glu  Phe Glu Val Leu Lys  Ala Phe Val 
    1265                 1270                 1275             


Val Asp  Met Met Glu Arg Leu  Arg Ile Ser Gln Lys  Trp Val Arg 
    1280                 1285                 1290             


Val Ala  Val Val Glu Tyr His  Asp Gly Ser His Ala  Tyr Ile Gly 
    1295                 1300                 1305             


Leu Lys  Asp Arg Lys Arg Pro  Ser Glu Leu Arg Arg  Ile Ala Ser 
    1310                 1315                 1320             


Gln Val  Lys Tyr Ala Gly Ser  Gln Val Ala Ser Thr  Ser Glu Val 
    1325                 1330                 1335             


Leu Lys  Tyr Thr Leu Phe Gln  Ile Phe Ser Lys Ile  Asp Arg Pro 
    1340                 1345                 1350             


Glu Ala  Ser Arg Ile Thr Leu  Leu Leu Met Ala Ser  Gln Glu Pro 
    1355                 1360                 1365             


Gln Arg  Met Ser Arg Asn Phe  Val Arg Tyr Val Gln  Gly Leu Lys 
    1370                 1375                 1380             


Lys Lys  Lys Val Ile Val Ile  Pro Val Gly Ile Gly  Pro His Ala 
    1385                 1390                 1395             


Asn Leu  Lys Gln Ile Arg Leu  Ile Glu Lys Gln Ala  Pro Glu Asn 
    1400                 1405                 1410             


Lys Ala  Phe Val Leu Ser Ser  Val Asp Glu Leu Glu  Gln Gln Arg 
    1415                 1420                 1425             


Asp Glu  Ile Val Ser Tyr Leu  Cys Asp Leu Ala Pro  Glu Ala Pro 
    1430                 1435                 1440             


Pro Pro  Thr Leu Pro Pro Asp  Met Ala Gln Val Thr  Val Gly Pro 
    1445                 1450                 1455             


Gly Leu  Leu Gly Val Ser Thr  Leu Gly Pro Lys Arg  Asn Ser Met 
    1460                 1465                 1470             


Val Leu  Asp Val Ala Phe Val  Leu Glu Gly Ser Asp  Lys Ile Gly 
    1475                 1480                 1485             


Glu Ala  Asp Phe Asn Arg Ser  Lys Glu Phe Met Glu  Glu Val Ile 
    1490                 1495                 1500             


Gln Arg  Met Asp Val Gly Gln  Asp Ser Ile His Val  Thr Val Leu 
    1505                 1510                 1515             


Gln Tyr  Ser Tyr Met Val Thr  Val Glu Tyr Pro Phe  Ser Glu Ala 
    1520                 1525                 1530             


Gln Ser  Lys Gly Asp Ile Leu  Gln Arg Val Arg Glu  Ile Arg Tyr 
    1535                 1540                 1545             


Gln Gly  Gly Asn Arg Thr Asn  Thr Gly Leu Ala Leu  Arg Tyr Leu 
    1550                 1555                 1560             


Ser Asp  His Ser Phe Leu Val  Ser Gln Gly Asp Arg  Glu Gln Ala 
    1565                 1570                 1575             


Pro Asn  Leu Val Tyr Met Val  Thr Gly Asn Pro Ala  Ser Asp Glu 
    1580                 1585                 1590             


Ile Lys  Arg Leu Pro Gly Asp  Ile Gln Val Val Pro  Ile Gly Val 
    1595                 1600                 1605             


Gly Pro  Asn Ala Asn Val Gln  Glu Leu Glu Arg Ile  Gly Trp Pro 
    1610                 1615                 1620             


Asn Ala  Pro Ile Leu Ile Gln  Asp Phe Glu Thr Leu  Pro Arg Glu 
    1625                 1630                 1635             


Ala Pro  Asp Leu Val Leu Gln  Arg Cys Cys Ser Gly  Glu Gly Leu 
    1640                 1645                 1650             


Gln Ile  Pro Thr Leu Ser Pro  Ala Pro Asp Cys Ser  Gln Pro Leu 
    1655                 1660                 1665             


Asp Val  Ile Leu Leu Leu Asp  Gly Ser Ser Ser Phe  Pro Ala Ser 
    1670                 1675                 1680             


Tyr Phe  Asp Glu Met Lys Ser  Phe Ala Lys Ala Phe  Ile Ser Lys 
    1685                 1690                 1695             


Ala Asn  Ile Gly Pro Arg Leu  Thr Gln Val Ser Val  Leu Gln Tyr 
    1700                 1705                 1710             


Gly Ser  Ile Thr Thr Ile Asp  Val Pro Trp Asn Val  Val Pro Glu 
    1715                 1720                 1725             


Lys Ala  His Leu Leu Ser Leu  Val Asp Val Met Gln  Arg Glu Gly 
    1730                 1735                 1740             


Gly Pro  Ser Gln Ile Gly Asp  Ala Leu Gly Phe Ala  Val Arg Tyr 
    1745                 1750                 1755             


Leu Thr  Ser Glu Met His Gly  Ala Arg Pro Gly Ala  Ser Lys Ala 
    1760                 1765                 1770             


Val Val  Ile Leu Val Thr Asp  Val Ser Val Asp Ser  Val Asp Ala 
    1775                 1780                 1785             


Ala Ala  Asp Ala Ala Arg Ser  Asn Arg Val Thr Val  Phe Pro Ile 
    1790                 1795                 1800             


Gly Ile  Gly Asp Arg Tyr Asp  Ala Ala Gln Leu Arg  Ile Leu Ala 
    1805                 1810                 1815             


Gly Pro  Ala Gly Asp Ser Asn  Val Val Lys Leu Gln  Arg Ile Glu 
    1820                 1825                 1830             


Asp Leu  Pro Thr Met Val Thr  Leu Gly Asn Ser Phe  Leu His Lys 
    1835                 1840                 1845             


Leu Cys  Ser Gly Phe Val Arg  Ile Cys Met Asp Glu  Asp Gly Asn 
    1850                 1855                 1860             


Glu Lys  Arg Pro Gly Asp Val  Trp Thr Leu Pro Asp  Gln Cys His 
    1865                 1870                 1875             


Thr Val  Thr Cys Gln Pro Asp  Gly Gln Thr Leu Leu  Lys Ser His 
    1880                 1885                 1890             


Arg Val  Asn Cys Asp Arg Gly  Leu Arg Pro Ser Cys  Pro Asn Ser 
    1895                 1900                 1905             


Gln Ser  Pro Val Lys Val Glu  Glu Thr Cys Gly Cys  Arg Trp Thr 
    1910                 1915                 1920             


Cys Pro  Cys Val Cys Thr Gly  Ser Ser Thr Arg His  Ile Val Thr 
    1925                 1930                 1935             


Phe Asp  Gly Gln Asn Phe Lys  Leu Thr Gly Ser Cys  Ser Tyr Val 
    1940                 1945                 1950             


Leu Phe  Gln Asn Lys Glu Gln  Asp Leu Glu Val Ile  Leu His Asn 
    1955                 1960                 1965             


Gly Ala  Cys Ser Pro Gly Ala  Arg Gln Gly Cys Met  Lys Ser Ile 
    1970                 1975                 1980             


Glu Val  Lys His Ser Ala Leu  Ser Val Glu Leu His  Ser Asp Met 
    1985                 1990                 1995             


Glu Val  Thr Val Asn Gly Arg  Leu Val Ser Val Pro  Tyr Val Gly 
    2000                 2005                 2010             


Gly Asn  Met Glu Val Asn Val  Tyr Gly Ala Ile Met  His Glu Val 
    2015                 2020                 2025             


Arg Phe  Asn His Leu Gly His  Ile Phe Thr Phe Thr  Pro Gln Asn 
    2030                 2035                 2040             


Asn Glu  Phe Gln Leu Gln Leu  Ser Pro Lys Thr Phe  Ala Ser Lys 
    2045                 2050                 2055             


Thr Tyr  Gly Leu Cys Gly Ile  Cys Asp Glu Asn Gly  Ala Asn Asp 
    2060                 2065                 2070             


Phe Met  Leu Arg Asp Gly Thr  Val Thr Thr Asp Trp  Lys Thr Leu 
    2075                 2080                 2085             


Val Gln  Glu Trp Thr Val Gln  Arg Pro Gly Gln Thr  Cys Gln Pro 
    2090                 2095                 2100             


Ile Leu  Glu Glu Gln Cys Leu  Val Pro Asp Ser Ser  His Cys Gln 
    2105                 2110                 2115             


Val Leu  Leu Leu Pro Leu Phe  Ala Glu Cys His Lys  Val Leu Ala 
    2120                 2125                 2130             


Pro Ala  Thr Phe Tyr Ala Ile  Cys Gln Gln Asp Ser  Cys His Gln 
    2135                 2140                 2145             


Glu Gln  Val Cys Glu Val Ile  Ala Ser Tyr Ala His  Leu Cys Arg 
    2150                 2155                 2160             


Thr Asn  Gly Val Cys Val Asp  Trp Arg Thr Pro Asp  Phe Cys Ala 
    2165                 2170                 2175             


Met Ser  Cys Pro Pro Ser Leu  Val Tyr Asn His Cys  Glu His Gly 
    2180                 2185                 2190             


Cys Pro  Arg His Cys Asp Gly  Asn Val Ser Ser Cys  Gly Asp His 
    2195                 2200                 2205             


Pro Ser  Glu Gly Cys Phe Cys  Pro Pro Asp Lys Val  Met Leu Glu 
    2210                 2215                 2220             


Gly Ser  Cys Val Pro Glu Glu  Ala Cys Thr Gln Cys  Ile Gly Glu 
    2225                 2230                 2235             


Asp Gly  Val Gln His Gln Phe  Leu Glu Ala Trp Val  Pro Asp His 
    2240                 2245                 2250             


Gln Pro  Cys Gln Ile Cys Thr  Cys Leu Ser Gly Arg  Lys Val Asn 
    2255                 2260                 2265             


Cys Thr  Thr Gln Pro Cys Pro  Thr Ala Lys Ala Pro  Thr Cys Gly 
    2270                 2275                 2280             


Leu Cys  Glu Val Ala Arg Leu  Arg Gln Asn Ala Asp  Gln Cys Cys 
    2285                 2290                 2295             


Pro Glu  Tyr Glu Cys Val Cys  Asp Pro Val Ser Cys  Asp Leu Pro 
    2300                 2305                 2310             


Pro Val  Pro His Cys Glu Arg  Gly Leu Gln Pro Thr  Leu Thr Asn 
    2315                 2320                 2325             


Pro Gly  Glu Cys Arg Pro Asn  Phe Thr Cys Ala Cys  Arg Lys Glu 
    2330                 2335                 2340             


Glu Cys  Lys Arg Val Ser Pro  Pro Ser Cys Pro Pro  His Arg Leu 
    2345                 2350                 2355             


Pro Thr  Leu Arg Lys Thr Gln  Cys Cys Asp Glu Tyr  Glu Cys Ala 
    2360                 2365                 2370             


Cys Asn  Cys Val Asn Ser Thr  Val Ser Cys Pro Leu  Gly Tyr Leu 
    2375                 2380                 2385             


Ala Ser  Thr Ala Thr Asn Asp  Cys Gly Cys Thr Thr  Thr Thr Cys 
    2390                 2395                 2400             


Leu Pro  Asp Lys Val Cys Val  His Arg Ser Thr Ile  Tyr Pro Val 
    2405                 2410                 2415             


Gly Gln  Phe Trp Glu Glu Gly  Cys Asp Val Cys Thr  Cys Thr Asp 
    2420                 2425                 2430             


Met Glu  Asp Ala Val Met Gly  Leu Arg Val Ala Gln  Cys Ser Gln 
    2435                 2440                 2445             


Lys Pro  Cys Glu Asp Ser Cys  Arg Ser Gly Phe Thr  Tyr Val Leu 
    2450                 2455                 2460             


His Glu  Gly Glu Cys Cys Gly  Arg Cys Leu Pro Ser  Ala Cys Glu 
    2465                 2470                 2475             


Val Val  Thr Gly Ser Pro Arg  Gly Asp Ser Gln Ser  Ser Trp Lys 
    2480                 2485                 2490             


Ser Val  Gly Ser Gln Trp Ala  Ser Pro Glu Asn Pro  Cys Leu Ile 
    2495                 2500                 2505             


Asn Glu  Cys Val Arg Val Lys  Glu Glu Val Phe Ile  Gln Gln Arg 
    2510                 2515                 2520             


Asn Val  Ser Cys Pro Gln Leu  Glu Val Pro Val Cys  Pro Ser Gly 
    2525                 2530                 2535             


Phe Gln  Leu Ser Cys Lys Thr  Ser Ala Cys Cys Pro  Ser Cys Arg 
    2540                 2545                 2550             


Cys Glu  Arg Met Glu Ala Cys  Met Leu Asn Gly Thr  Val Ile Gly 
    2555                 2560                 2565             


Pro Gly  Lys Thr Val Met Ile  Asp Val Cys Thr Thr  Cys Arg Cys 
    2570                 2575                 2580             


Met Val  Gln Val Gly Val Ile  Ser Gly Phe Lys Leu  Glu Cys Arg 
    2585                 2590                 2595             


Lys Thr  Thr Cys Asn Pro Cys  Pro Leu Gly Tyr Lys  Glu Glu Asn 
    2600                 2605                 2610             


Asn Thr  Gly Glu Cys Cys Gly  Arg Cys Leu Pro Thr  Ala Cys Thr 
    2615                 2620                 2625             


Ile Gln  Leu Arg Gly Gly Gln  Ile Met Thr Leu Lys  Arg Asp Glu 
    2630                 2635                 2640             


Thr Leu  Gln Asp Gly Cys Asp  Thr His Phe Cys Lys  Val Asn Glu 
    2645                 2650                 2655             


Arg Gly  Glu Tyr Phe Trp Glu  Lys Arg Val Thr Gly  Cys Pro Pro 
    2660                 2665                 2670             


Phe Asp  Glu His Lys Cys Leu  Ala Glu Gly Gly Lys  Ile Met Lys 
    2675                 2680                 2685             


Ile Pro  Gly Thr Cys Cys Asp  Thr Cys Glu Glu Pro  Glu Cys Asn 
    2690                 2695                 2700             


Asp Ile  Thr Ala Arg Leu Gln  Tyr Val Lys Val Gly  Ser Cys Lys 
    2705                 2710                 2715             


Ser Glu  Val Glu Val Asp Ile  His Tyr Cys Gln Gly  Lys Cys Ala 
    2720                 2725                 2730             


Ser Lys  Ala Met Tyr Ser Ile  Asp Ile Asn Asp Val  Gln Asp Gln 
    2735                 2740                 2745             


Cys Ser  Cys Cys Ser Pro Thr  Arg Thr Glu Pro Met  Gln Val Ala 
    2750                 2755                 2760             


Leu His  Cys Thr Asn Gly Ser  Val Val Tyr His Glu  Val Leu Asn 
    2765                 2770                 2775             


Ala Met  Glu Cys Lys Cys Ser  Pro Arg Lys Cys Ser  Lys 
    2780                 2785                 2790     


<210>  31
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  31

Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr Ala Arg Cys Ser Leu Phe 
1               5                   10                  15      


Gly Ser Asp Phe Val Asn Thr Phe Asp Gly Ser Met Tyr Ser Phe Ala 
            20                  25                  30          


Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly Cys Gln Lys Arg Ser Phe 
        35                  40                  45              


Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys Arg Val Ser Leu Ser Val 
    50                  55                  60                  


Tyr Leu Gly Glu Phe Phe Asp Ile His Leu Phe Val Asn Gly Thr Val 
65                  70                  75                  80  


Thr Gln Gly Asp Gln Arg Val Ser Met Pro Tyr Ala Ser Lys Gly Leu 
                85                  90                  95      


Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys Leu Ser Gly Glu Ala Tyr 
            100                 105                 110         


Gly Phe Val Ala Arg Ile Asp Gly Ser Gly Asn Phe Gln Val Leu Leu 
        115                 120                 125             


Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly Leu Cys Gly Asn Phe Asn 
    130                 135                 140                 


Ile Phe Ala Glu Asp Asp Phe Met Thr Gln Glu Gly Thr Leu Thr Ser 
145                 150                 155                 160 


Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala Leu Ser Ser Gly Glu Gln 
                165                 170                 175     


Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser Ser Cys Asn Ile Ser Ser 
            180                 185                 190         


Gly Glu Met Gln Lys Gly Leu Trp Glu Gln Cys Gln Leu Leu Lys Ser 
        195                 200                 205             


Thr Ser Val Phe Ala Arg Cys His Pro Leu Val Asp Pro Glu Pro Phe 
    210                 215                 220                 


Val Ala Leu Cys Glu Lys Thr Leu Cys Glu Cys Ala Gly Gly Leu Glu 
225                 230                 235                 240 


Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala Arg Thr Cys Ala Gln Glu 
                245                 250                 255     


Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser Ala Cys Ser Pro Val 
            260                 265                 270         


Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser Pro Cys Ala Arg 
        275                 280                 285             


Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln Glu Arg Cys Val 
    290                 295                 300                 


Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp Glu Gly Leu Cys 
305                 310                 315                 320 


Val Glu Ser Thr Glu Cys Pro Cys Val His Ser Gly Lys Arg Tyr Pro 
                325                 330                 335     


Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn Thr Cys Ile Cys Arg Asn 
            340                 345                 350         


Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys Pro Gly Glu Cys Leu Val 
        355                 360                 365             


Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg Tyr Phe Thr Phe 
    370                 375                 380                 


Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys Gln Asp His Ser 
385                 390                 395                 400 


Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp Asp Arg Asp Ala 
                405                 410                 415     


Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly Leu His Asn Ser 
            420                 425                 430         


Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met Asp Gly Gln Asp 
        435                 440                 445             


Val Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile Gln His Thr Val 
    450                 455                 460                 


Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu Gln Met Asp Trp 
465                 470                 475                 480 


Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro Val Tyr Ala Gly 
                485                 490                 495     


Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn Gln Gly Asp Asp 
            500                 505                 510         


Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro Arg Val Glu Asp Phe Gly 
        515                 520                 525             


Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu Gln Lys Gln His 
    530                 535                 540                 


Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg Phe Ser Glu Glu 
545                 550                 555                 560 


Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala Cys His Arg Ala 
                565                 570                 575     


Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg Tyr Asp Val Cys Ser 
            580                 585                 590         


Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly Ala Leu Ala Ser Tyr Ala 
        595                 600                 605             


Ala Ala Cys Ala Gly Arg Gly Val Arg Val Ala Trp Arg Glu Pro Gly 
    610                 615                 620                 


Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln Val Tyr Leu Gln Cys Gly 
625                 630                 635                 640 


Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser Tyr Pro Asp Glu Glu 
                645                 650                 655     


Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe Cys Pro Pro Gly Leu Tyr 
            660                 665                 670         


Met Asp Glu Arg Gly Asp Cys Val Pro Lys Ala Gln Cys Pro Cys Tyr 
        675                 680                 685             


Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile Phe Ser Asp His His 
    690                 695                 700                 


Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His Cys Thr Met Ser Gly 
705                 710                 715                 720 


Val Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser Pro Leu Ser 
                725                 730                 735     


His Arg Ser Lys Arg 
            740     


<210>  32
<211>  2050
<212>  PRT
<213>  Homo sapiens

<400>  32

Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp 
1               5                   10                  15      


Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr 
            20                  25                  30          


Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro 
        35                  40                  45              


Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys 
    50                  55                  60                  


Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys 
65                  70                  75                  80  


Ile Gly Cys Asn Thr Cys Val Cys Gln Asp Arg Lys Trp Asn Cys Thr 
                85                  90                  95      


Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr 
            100                 105                 110         


Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr 
        115                 120                 125             


Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile 
    130                 135                 140                 


Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys 
145                 150                 155                 160 


Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly 
                165                 170                 175     


Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu Thr His Phe Glu Val 
            180                 185                 190         


Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser 
        195                 200                 205             


Val Val Trp Asp Arg His Leu Ser Ile Ser Val Val Leu Lys Gln Thr 
    210                 215                 220                 


Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn Phe Asp Gly Ile Gln 
225                 230                 235                 240 


Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val Glu Glu Asp Pro Val 
                245                 250                 255     


Asp Phe Gly Asn Ser Trp Lys Val Ser Ser Gln Cys Ala Asp Thr Arg 
            260                 265                 270         


Lys Val Pro Leu Asp Ser Ser Pro Ala Thr Cys His Asn Asn Ile Met 
        275                 280                 285             


Lys Gln Thr Met Val Asp Ser Ser Cys Arg Ile Leu Thr Ser Asp Val 
    290                 295                 300                 


Phe Gln Asp Cys Asn Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp Val 
305                 310                 315                 320 


Cys Ile Tyr Asp Thr Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala Cys 
                325                 330                 335     


Phe Cys Asp Thr Ile Ala Ala Tyr Ala His Val Cys Ala Gln His Gly 
            340                 345                 350         


Lys Val Val Thr Trp Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys Glu 
        355                 360                 365             


Glu Arg Asn Leu Arg Glu Asn Gly Tyr Glu Cys Glu Trp Arg Tyr Asn 
    370                 375                 380                 


Ser Cys Ala Pro Ala Cys Gln Val Thr Cys Gln His Pro Glu Pro Leu 
385                 390                 395                 400 


Ala Cys Pro Val Gln Cys Val Glu Gly Cys His Ala His Cys Pro Pro 
                405                 410                 415     


Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr Cys Val Asp Pro Glu Asp 
            420                 425                 430         


Cys Pro Val Cys Glu Val Ala Gly Arg Arg Phe Ala Ser Gly Lys Lys 
        435                 440                 445             


Val Thr Leu Asn Pro Ser Asp Pro Glu His Cys Gln Ile Cys His Cys 
    450                 455                 460                 


Asp Val Val Asn Leu Thr Cys Glu Ala Cys Gln Glu Pro Gly Gly Leu 
465                 470                 475                 480 


Val Val Pro Pro Thr Asp Ala Pro Val Ser Pro Thr Thr Leu Tyr Val 
                485                 490                 495     


Glu Asp Ile Ser Glu Pro Pro Leu His Asp Phe Tyr Cys Ser Arg Leu 
            500                 505                 510         


Leu Asp Leu Val Phe Leu Leu Asp Gly Ser Ser Arg Leu Ser Glu Ala 
        515                 520                 525             


Glu Phe Glu Val Leu Lys Ala Phe Val Val Asp Met Met Glu Arg Leu 
    530                 535                 540                 


Arg Ile Ser Gln Lys Trp Val Arg Val Ala Val Val Glu Tyr His Asp 
545                 550                 555                 560 


Gly Ser His Ala Tyr Ile Gly Leu Lys Asp Arg Lys Arg Pro Ser Glu 
                565                 570                 575     


Leu Arg Arg Ile Ala Ser Gln Val Lys Tyr Ala Gly Ser Gln Val Ala 
            580                 585                 590         


Ser Thr Ser Glu Val Leu Lys Tyr Thr Leu Phe Gln Ile Phe Ser Lys 
        595                 600                 605             


Ile Asp Arg Pro Glu Ala Ser Arg Ile Thr Leu Leu Leu Met Ala Ser 
    610                 615                 620                 


Gln Glu Pro Gln Arg Met Ser Arg Asn Phe Val Arg Tyr Val Gln Gly 
625                 630                 635                 640 


Leu Lys Lys Lys Lys Val Ile Val Ile Pro Val Gly Ile Gly Pro His 
                645                 650                 655     


Ala Asn Leu Lys Gln Ile Arg Leu Ile Glu Lys Gln Ala Pro Glu Asn 
            660                 665                 670         


Lys Ala Phe Val Leu Ser Ser Val Asp Glu Leu Glu Gln Gln Arg Asp 
        675                 680                 685             


Glu Ile Val Ser Tyr Leu Cys Asp Leu Ala Pro Glu Ala Pro Pro Pro 
    690                 695                 700                 


Thr Leu Pro Pro Asp Met Ala Gln Val Thr Val Gly Pro Gly Leu Leu 
705                 710                 715                 720 


Gly Val Ser Thr Leu Gly Pro Lys Arg Asn Ser Met Val Leu Asp Val 
                725                 730                 735     


Ala Phe Val Leu Glu Gly Ser Asp Lys Ile Gly Glu Ala Asp Phe Asn 
            740                 745                 750         


Arg Ser Lys Glu Phe Met Glu Glu Val Ile Gln Arg Met Asp Val Gly 
        755                 760                 765             


Gln Asp Ser Ile His Val Thr Val Leu Gln Tyr Ser Tyr Met Val Thr 
    770                 775                 780                 


Val Glu Tyr Pro Phe Ser Glu Ala Gln Ser Lys Gly Asp Ile Leu Gln 
785                 790                 795                 800 


Arg Val Arg Glu Ile Arg Tyr Gln Gly Gly Asn Arg Thr Asn Thr Gly 
                805                 810                 815     


Leu Ala Leu Arg Tyr Leu Ser Asp His Ser Phe Leu Val Ser Gln Gly 
            820                 825                 830         


Asp Arg Glu Gln Ala Pro Asn Leu Val Tyr Met Val Thr Gly Asn Pro 
        835                 840                 845             


Ala Ser Asp Glu Ile Lys Arg Leu Pro Gly Asp Ile Gln Val Val Pro 
    850                 855                 860                 


Ile Gly Val Gly Pro Asn Ala Asn Val Gln Glu Leu Glu Arg Ile Gly 
865                 870                 875                 880 


Trp Pro Asn Ala Pro Ile Leu Ile Gln Asp Phe Glu Thr Leu Pro Arg 
                885                 890                 895     


Glu Ala Pro Asp Leu Val Leu Gln Arg Cys Cys Ser Gly Glu Gly Leu 
            900                 905                 910         


Gln Ile Pro Thr Leu Ser Pro Ala Pro Asp Cys Ser Gln Pro Leu Asp 
        915                 920                 925             


Val Ile Leu Leu Leu Asp Gly Ser Ser Ser Phe Pro Ala Ser Tyr Phe 
    930                 935                 940                 


Asp Glu Met Lys Ser Phe Ala Lys Ala Phe Ile Ser Lys Ala Asn Ile 
945                 950                 955                 960 


Gly Pro Arg Leu Thr Gln Val Ser Val Leu Gln Tyr Gly Ser Ile Thr 
                965                 970                 975     


Thr Ile Asp Val Pro Trp Asn Val Val Pro Glu Lys Ala His Leu Leu 
            980                 985                 990         


Ser Leu Val Asp Val Met Gln Arg  Glu Gly Gly Pro Ser  Gln Ile Gly 
        995                 1000                 1005             


Asp Ala  Leu Gly Phe Ala Val  Arg Tyr Leu Thr Ser  Glu Met His 
    1010                 1015                 1020             


Gly Ala  Arg Pro Gly Ala Ser  Lys Ala Val Val Ile  Leu Val Thr 
    1025                 1030                 1035             


Asp Val  Ser Val Asp Ser Val  Asp Ala Ala Ala Asp  Ala Ala Arg 
    1040                 1045                 1050             


Ser Asn  Arg Val Thr Val Phe  Pro Ile Gly Ile Gly  Asp Arg Tyr 
    1055                 1060                 1065             


Asp Ala  Ala Gln Leu Arg Ile  Leu Ala Gly Pro Ala  Gly Asp Ser 
    1070                 1075                 1080             


Asn Val  Val Lys Leu Gln Arg  Ile Glu Asp Leu Pro  Thr Met Val 
    1085                 1090                 1095             


Thr Leu  Gly Asn Ser Phe Leu  His Lys Leu Cys Ser  Gly Phe Val 
    1100                 1105                 1110             


Arg Ile  Cys Met Asp Glu Asp  Gly Asn Glu Lys Arg  Pro Gly Asp 
    1115                 1120                 1125             


Val Trp  Thr Leu Pro Asp Gln  Cys His Thr Val Thr  Cys Gln Pro 
    1130                 1135                 1140             


Asp Gly  Gln Thr Leu Leu Lys  Ser His Arg Val Asn  Cys Asp Arg 
    1145                 1150                 1155             


Gly Leu  Arg Pro Ser Cys Pro  Asn Ser Gln Ser Pro  Val Lys Val 
    1160                 1165                 1170             


Glu Glu  Thr Cys Gly Cys Arg  Trp Thr Cys Pro Cys  Val Cys Thr 
    1175                 1180                 1185             


Gly Ser  Ser Thr Arg His Ile  Val Thr Phe Asp Gly  Gln Asn Phe 
    1190                 1195                 1200             


Lys Leu  Thr Gly Ser Cys Ser  Tyr Val Leu Phe Gln  Asn Lys Glu 
    1205                 1210                 1215             


Gln Asp  Leu Glu Val Ile Leu  His Asn Gly Ala Cys  Ser Pro Gly 
    1220                 1225                 1230             


Ala Arg  Gln Gly Cys Met Lys  Ser Ile Glu Val Lys  His Ser Ala 
    1235                 1240                 1245             


Leu Ser  Val Glu Leu His Ser  Asp Met Glu Val Thr  Val Asn Gly 
    1250                 1255                 1260             


Arg Leu  Val Ser Val Pro Tyr  Val Gly Gly Asn Met  Glu Val Asn 
    1265                 1270                 1275             


Val Tyr  Gly Ala Ile Met His  Glu Val Arg Phe Asn  His Leu Gly 
    1280                 1285                 1290             


His Ile  Phe Thr Phe Thr Pro  Gln Asn Asn Glu Phe  Gln Leu Gln 
    1295                 1300                 1305             


Leu Ser  Pro Lys Thr Phe Ala  Ser Lys Thr Tyr Gly  Leu Cys Gly 
    1310                 1315                 1320             


Ile Cys  Asp Glu Asn Gly Ala  Asn Asp Phe Met Leu  Arg Asp Gly 
    1325                 1330                 1335             


Thr Val  Thr Thr Asp Trp Lys  Thr Leu Val Gln Glu  Trp Thr Val 
    1340                 1345                 1350             


Gln Arg  Pro Gly Gln Thr Cys  Gln Pro Ile Leu Glu  Glu Gln Cys 
    1355                 1360                 1365             


Leu Val  Pro Asp Ser Ser His  Cys Gln Val Leu Leu  Leu Pro Leu 
    1370                 1375                 1380             


Phe Ala  Glu Cys His Lys Val  Leu Ala Pro Ala Thr  Phe Tyr Ala 
    1385                 1390                 1395             


Ile Cys  Gln Gln Asp Ser Cys  His Gln Glu Gln Val  Cys Glu Val 
    1400                 1405                 1410             


Ile Ala  Ser Tyr Ala His Leu  Cys Arg Thr Asn Gly  Val Cys Val 
    1415                 1420                 1425             


Asp Trp  Arg Thr Pro Asp Phe  Cys Ala Met Ser Cys  Pro Pro Ser 
    1430                 1435                 1440             


Leu Val  Tyr Asn His Cys Glu  His Gly Cys Pro Arg  His Cys Asp 
    1445                 1450                 1455             


Gly Asn  Val Ser Ser Cys Gly  Asp His Pro Ser Glu  Gly Cys Phe 
    1460                 1465                 1470             


Cys Pro  Pro Asp Lys Val Met  Leu Glu Gly Ser Cys  Val Pro Glu 
    1475                 1480                 1485             


Glu Ala  Cys Thr Gln Cys Ile  Gly Glu Asp Gly Val  Gln His Gln 
    1490                 1495                 1500             


Phe Leu  Glu Ala Trp Val Pro  Asp His Gln Pro Cys  Gln Ile Cys 
    1505                 1510                 1515             


Thr Cys  Leu Ser Gly Arg Lys  Val Asn Cys Thr Thr  Gln Pro Cys 
    1520                 1525                 1530             


Pro Thr  Ala Lys Ala Pro Thr  Cys Gly Leu Cys Glu  Val Ala Arg 
    1535                 1540                 1545             


Leu Arg  Gln Asn Ala Asp Gln  Cys Cys Pro Glu Tyr  Glu Cys Val 
    1550                 1555                 1560             


Cys Asp  Pro Val Ser Cys Asp  Leu Pro Pro Val Pro  His Cys Glu 
    1565                 1570                 1575             


Arg Gly  Leu Gln Pro Thr Leu  Thr Asn Pro Gly Glu  Cys Arg Pro 
    1580                 1585                 1590             


Asn Phe  Thr Cys Ala Cys Arg  Lys Glu Glu Cys Lys  Arg Val Ser 
    1595                 1600                 1605             


Pro Pro  Ser Cys Pro Pro His  Arg Leu Pro Thr Leu  Arg Lys Thr 
    1610                 1615                 1620             


Gln Cys  Cys Asp Glu Tyr Glu  Cys Ala Cys Asn Cys  Val Asn Ser 
    1625                 1630                 1635             


Thr Val  Ser Cys Pro Leu Gly  Tyr Leu Ala Ser Thr  Ala Thr Asn 
    1640                 1645                 1650             


Asp Cys  Gly Cys Thr Thr Thr  Thr Cys Leu Pro Asp  Lys Val Cys 
    1655                 1660                 1665             


Val His  Arg Ser Thr Ile Tyr  Pro Val Gly Gln Phe  Trp Glu Glu 
    1670                 1675                 1680             


Gly Cys  Asp Val Cys Thr Cys  Thr Asp Met Glu Asp  Ala Val Met 
    1685                 1690                 1695             


Gly Leu  Arg Val Ala Gln Cys  Ser Gln Lys Pro Cys  Glu Asp Ser 
    1700                 1705                 1710             


Cys Arg  Ser Gly Phe Thr Tyr  Val Leu His Glu Gly  Glu Cys Cys 
    1715                 1720                 1725             


Gly Arg  Cys Leu Pro Ser Ala  Cys Glu Val Val Thr  Gly Ser Pro 
    1730                 1735                 1740             


Arg Gly  Asp Ser Gln Ser Ser  Trp Lys Ser Val Gly  Ser Gln Trp 
    1745                 1750                 1755             


Ala Ser  Pro Glu Asn Pro Cys  Leu Ile Asn Glu Cys  Val Arg Val 
    1760                 1765                 1770             


Lys Glu  Glu Val Phe Ile Gln  Gln Arg Asn Val Ser  Cys Pro Gln 
    1775                 1780                 1785             


Leu Glu  Val Pro Val Cys Pro  Ser Gly Phe Gln Leu  Ser Cys Lys 
    1790                 1795                 1800             


Thr Ser  Ala Cys Cys Pro Ser  Cys Arg Cys Glu Arg  Met Glu Ala 
    1805                 1810                 1815             


Cys Met  Leu Asn Gly Thr Val  Ile Gly Pro Gly Lys  Thr Val Met 
    1820                 1825                 1830             


Ile Asp  Val Cys Thr Thr Cys  Arg Cys Met Val Gln  Val Gly Val 
    1835                 1840                 1845             


Ile Ser  Gly Phe Lys Leu Glu  Cys Arg Lys Thr Thr  Cys Asn Pro 
    1850                 1855                 1860             


Cys Pro  Leu Gly Tyr Lys Glu  Glu Asn Asn Thr Gly  Glu Cys Cys 
    1865                 1870                 1875             


Gly Arg  Cys Leu Pro Thr Ala  Cys Thr Ile Gln Leu  Arg Gly Gly 
    1880                 1885                 1890             


Gln Ile  Met Thr Leu Lys Arg  Asp Glu Thr Leu Gln  Asp Gly Cys 
    1895                 1900                 1905             


Asp Thr  His Phe Cys Lys Val  Asn Glu Arg Gly Glu  Tyr Phe Trp 
    1910                 1915                 1920             


Glu Lys  Arg Val Thr Gly Cys  Pro Pro Phe Asp Glu  His Lys Cys 
    1925                 1930                 1935             


Leu Ala  Glu Gly Gly Lys Ile  Met Lys Ile Pro Gly  Thr Cys Cys 
    1940                 1945                 1950             


Asp Thr  Cys Glu Glu Pro Glu  Cys Asn Asp Ile Thr  Ala Arg Leu 
    1955                 1960                 1965             


Gln Tyr  Val Lys Val Gly Ser  Cys Lys Ser Glu Val  Glu Val Asp 
    1970                 1975                 1980             


Ile His  Tyr Cys Gln Gly Lys  Cys Ala Ser Lys Ala  Met Tyr Ser 
    1985                 1990                 1995             


Ile Asp  Ile Asn Asp Val Gln  Asp Gln Cys Ser Cys  Cys Ser Pro 
    2000                 2005                 2010             


Thr Arg  Thr Glu Pro Met Gln  Val Ala Leu His Cys  Thr Asn Gly 
    2015                 2020                 2025             


Ser Val  Val Tyr His Glu Val  Leu Asn Ala Met Glu  Cys Lys Cys 
    2030                 2035                 2040             


Ser Pro  Arg Lys Cys Ser Lys  
    2045                 2050 


<210>  33
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  33

Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly Ser 
1               5                   10                  15      


Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly Cys 
            20                  25                  30          


Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys Arg 
        35                  40                  45              


Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu Phe 
    50                  55                  60                  


Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro Tyr 
65                  70                  75                  80  


Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys Leu 
                85                  90                  95      


Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly Asn 
            100                 105                 110         


Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly Leu 
        115                 120                 125             


Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln Glu 
    130                 135                 140                 


Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala Leu 
145                 150                 155                 160 


Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser Ser 
                165                 170                 175     


Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln Cys 
            180                 185                 190         


Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
        195                 200                 205         


<210>  34
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  34

Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser Pro Cys Ala Arg 
1               5                   10                  15      


Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln Glu Arg Cys Val 
            20                  25                  30          


Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp Glu Gly Leu Cys 
        35                  40                  45              


Val Glu Ser Thr Glu Cys 
    50                  


<210>  35
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  35

Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg 
1               5                   10                  15      


Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys 
            20                  25                  30          


Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp 
        35                  40                  45              


Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly 
    50                  55                  60                  


Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met 
65                  70                  75                  80  


Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile 
                85                  90                  95      


Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu 
            100                 105                 110         


Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro 
        115                 120                 125             


Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn 
    130                 135                 140                 


Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro Arg Val 
145                 150                 155                 160 


Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu 
                165                 170                 175     


Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg 
            180                 185                 190         


Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala 
        195                 200                 205             


Cys His Arg Ala 
    210         


<210>  36
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  36

Cys Pro Lys Gly Gln Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu 
1               5                   10                  15      


Thr Cys Arg Ser Leu Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys 
            20                  25                  30          


Leu Glu Gly Cys Phe Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly 
        35                  40                  45              


Asp Cys Val Pro Lys Ala Gln Cys 
    50                  55      


<210>  37
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  37

Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr 
1               5                   10                  15      


Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly 
            20                  25                  30          


Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala 
        35                  40                  45              


Leu Glu Arg Cys 
    50          


<210>  38
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  38

Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu 
1               5                   10                  15      


Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr 
            20                  25                  30          


Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly 
        35                  40                  45              


Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val 
    50                  55                  60                  


Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg 
65                  70                  75                  80  


Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr 
                85                  90                  95      


Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His 
            100                 105                 110         


Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys 
        115                 120                 125             


Gly Leu Cys Gly Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser 
    130                 135                 140                 


Ser Asn Leu Gln Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp 
145                 150                 155                 160 


Lys Val Ser Ser Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser 
                165                 170                 175     


Ser Pro Ala Thr Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp 
            180                 185                 190         


Ser Ser Cys Arg Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn Lys 
        195                 200                 205             


Leu 
    


<210>  39
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  39

Tyr Asn Ser Cys Ala Pro Ala Cys Gln Val Thr Cys Gln His Pro Glu 
1               5                   10                  15      


Pro Leu Ala Cys Pro Val Gln Cys Val Glu Gly Cys His Ala His Cys 
            20                  25                  30          


Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr Cys Val Asp Pro 
        35                  40                  45              


Glu Asp Cys 
    50      


<210>  40
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Leu Val Phe Leu Leu Asp Gly Ser Ser Arg Leu Ser Glu Ala Glu 
1               5                   10                  15      


Phe Glu Val Leu Lys Ala Phe Val Val Asp Met Met Glu Arg Leu Arg 
            20                  25                  30          


Ile Ser Gln Lys Trp Val Arg Val Ala Val Val Glu Tyr His Asp Gly 
        35                  40                  45              


Ser His Ala Tyr Ile Gly Leu Lys Asp Arg Lys Arg Pro Ser Glu Leu 
    50                  55                  60                  


Arg Arg Ile Ala Ser Gln Val Lys Tyr Ala Gly Ser Gln Val Ala Ser 
65                  70                  75                  80  


Thr Ser Glu Val Leu Lys Tyr Thr Leu Phe Gln Ile Phe Ser Lys Ile 
                85                  90                  95      


Asp Arg Pro Glu Ala Ser Arg Ile Thr Leu Leu Leu Met Ala Ser Gln 
            100                 105                 110         


Glu Pro Gln Arg Met Ser Arg Asn Phe Val Arg Tyr Val Gln Gly Leu 
        115                 120                 125             


Lys Lys Lys Lys Val Ile Val Ile Pro Val Gly Ile Gly Pro His Ala 
    130                 135                 140                 


Asn Leu Lys Gln Ile Arg Leu Ile Glu Lys Gln Ala Pro Glu Asn Lys 
145                 150                 155                 160 


Ala Phe Val Leu Ser Ser Val Asp Glu Leu Glu Gln Gln Arg Asp Glu 
                165                 170                 175     


Ile 
    


<210>  41
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  41

Asp Val Ala Phe Val Leu Glu Gly Ser Asp Lys Ile Gly Glu Ala Asp 
1               5                   10                  15      


Phe Asn Arg Ser Lys Glu Phe Met Glu Glu Val Ile Gln Arg Met Asp 
            20                  25                  30          


Val Gly Gln Asp Ser Ile His Val Thr Val Leu Gln Tyr Ser Tyr Met 
        35                  40                  45              


Val Thr Val Glu Tyr Pro Phe Ser Glu Ala Gln Ser Lys Gly Asp Ile 
    50                  55                  60                  


Leu Gln Arg Val Arg Glu Ile Arg Tyr Gln Gly Gly Asn Arg Thr Asn 
65                  70                  75                  80  


Thr Gly Leu Ala Leu Arg Tyr Leu Ser Asp His Ser Phe Leu Val Ser 
                85                  90                  95      


Gln Gly Asp Arg Glu Gln Ala Pro Asn Leu Val Tyr Met Val Thr Gly 
            100                 105                 110         


Asn Pro Ala Ser Asp Glu Ile Lys Arg Leu Pro Gly Asp Ile Gln Val 
        115                 120                 125             


Val Pro Ile Gly Val Gly Pro Asn Ala Asn Val Gln Glu Leu Glu Arg 
    130                 135                 140                 


Ile Gly Trp Pro Asn Ala Pro Ile Leu Ile Gln Asp Phe Glu Thr Leu 
145                 150                 155                 160 


Pro Arg Glu Ala Pro Asp Leu Val 
                165             


<210>  42
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  42

Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser Phe Pro Ala Ser Tyr 
1               5                   10                  15      


Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe Ile Ser Lys Ala Asn 
            20                  25                  30          


Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu Gln Tyr Gly Ser Ile 
        35                  40                  45              


Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro Glu Lys Ala His Leu 
    50                  55                  60                  


Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly Gly Pro Ser Gln Ile 
65                  70                  75                  80  


Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu Thr Ser Glu Met His 
                85                  90                  95      


Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val Ile Leu Val Thr Asp 
            100                 105                 110         


Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp Ala Ala Arg Ser Asn 
        115                 120                 125             


Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp Arg Tyr Asp Ala Ala 
    130                 135                 140                 


Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp Ser Asn Val Val Lys 
145                 150                 155                 160 


Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val Thr Leu Gly Asn Ser 
                165                 170                 175     


Phe Leu His Lys Leu 
            180     


<210>  43
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  43

Val Cys Thr Gly Ser Ser Thr Arg His Ile Val Thr Phe Asp Gly Gln 
1               5                   10                  15      


Asn Phe Lys Leu Thr Gly Ser Cys Ser Tyr Val Leu Phe Gln Asn Lys 
            20                  25                  30          


Glu Gln Asp Leu Glu Val Ile Leu His Asn Gly Ala Cys Ser Pro Gly 
        35                  40                  45              


Ala Arg Gln Gly Cys Met Lys Ser Ile Glu Val Lys His Ser Ala Leu 
    50                  55                  60                  


Ser Val Glu Leu His Ser Asp Met Glu Val Thr Val Asn Gly Arg Leu 
65                  70                  75                  80  


Val Ser Val Pro Tyr Val Gly Gly Asn Met Glu Val Asn Val Tyr Gly 
                85                  90                  95      


Ala Ile Met His Glu Val Arg Phe Asn His Leu Gly His Ile Phe Thr 
            100                 105                 110         


Phe Thr Pro Gln Asn Asn Glu Phe Gln Leu Gln Leu Ser Pro Lys Thr 
        115                 120                 125             


Phe Ala Ser Lys Thr Tyr Gly Leu Cys Gly Ile Cys Asp Glu Asn Gly 
    130                 135                 140                 


Ala Asn Asp Phe Met Leu Arg Asp Gly Thr Val Thr Thr Asp Trp Lys 
145                 150                 155                 160 


Thr Leu Val Gln Glu Trp Thr Val Gln Arg Pro Gly Gln Thr Cys Gln 
                165                 170                 175     


Pro Ile Leu Glu Glu Gln Cys Leu Val Pro Asp Ser Ser His Cys Gln 
            180                 185                 190         


Val Leu Leu Leu Pro Leu Phe Ala Glu Cys His Lys Val 
        195                 200                 205 


<210>  44
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  44

Thr Gln Cys Ile Gly Glu Asp Gly Val Gln His Gln Phe Leu Glu Ala 
1               5                   10                  15      


Trp Val Pro Asp His Gln Pro Cys Gln Ile Cys Thr Cys Leu Ser Gly 
            20                  25                  30          


Arg Lys Val Asn Cys Thr Thr Gln Pro Cys Pro Thr Ala Lys Ala Pro 
        35                  40                  45              


Thr Cys Gly Leu Cys Glu Val Ala Arg Leu Arg Gln Asn Ala Asp Gln 
    50                  55                  60                  


Cys Cys Pro Glu Tyr Glu Cys Val Cys Asp 
65                  70                  


<210>  45
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  45

Lys Val Cys Val His Arg Ser Thr Ile Tyr Pro Val Gly Gln Phe Trp 
1               5                   10                  15      


Glu Glu Gly Cys Asp Val Cys Thr Cys Thr Asp Met Glu Asp Ala Val 
            20                  25                  30          


Met Gly Leu Arg Val Ala Gln Cys Ser Gln Lys Pro Cys Glu Asp Ser 
        35                  40                  45              


Cys Arg Ser Gly Phe Thr Tyr Val Leu His Glu Gly Glu Cys Cys Gly 
    50                  55                  60                  


Arg Cys Leu 
65          


<210>  46
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  46

Glu Ala Cys Met Leu Asn Gly Thr Val Ile Gly Pro Gly Lys Thr Val 
1               5                   10                  15      


Met Ile Asp Val Cys Thr Thr Cys Arg Cys Met Val Gln Val Gly Val 
            20                  25                  30          


Ile Ser Gly Phe Lys Leu Glu Cys Arg Lys Thr Thr Cys Asn Pro Cys 
        35                  40                  45              


Pro Leu Gly Tyr Lys Glu Glu Asn Asn Thr Gly Glu Cys Cys Gly Arg 
    50                  55                  60                  


Cys Leu 
65      


<210>  47
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  47

Cys Asn Asp Ile Thr Ala Arg Leu Gln Tyr Val Lys Val Gly Ser Cys 
1               5                   10                  15      


Lys Ser Glu Val Glu Val Asp Ile His Tyr Cys Gln Gly Lys Cys Ala 
            20                  25                  30          


Ser Lys Ala Met Tyr Ser Ile Asp Ile Asn Asp Val Gln Asp Gln Cys 
        35                  40                  45              


Ser Cys Cys Ser Pro Thr Arg Thr Glu Pro Met Gln Val Ala Leu His 
    50                  55                  60                  


Cys Thr Asn Gly Ser Val Val Tyr His Glu Val Leu Asn Ala Met Glu 
65                  70                  75                  80  


Cys Lys Cys Ser Pro Arg Lys Cys Ser 
                85                  


<210>  48
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  48

Val Gly Gln Gly Thr Pro Ser Leu Val Pro His Glu Glu Ala Ala Ala 
1               5                   10                  15      


Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu Glu Trp Ser 
            20                  25                  30          


Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro Arg Arg Leu 
        35                  40                  45              


Leu Pro Gly Pro Gln Glu Asn Ser Val Gln Ser Ser 
    50                  55                  60  


<210>  49
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  49

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  50
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein concensus sequence       

<400>  50

Xaa Xaa Xaa Xaa Gly Arg Thr Thr Ala Thr Xaa Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Xaa Ala Xaa Gln Xaa 
            20                  25                  30          


Arg Arg Leu Leu Xaa Gly Xaa 
        35                  


<210>  51
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation A1144V

<400>  51

Val Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  52
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation A1145V

<400>  52

Ala Val Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  53
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation A1146V

<400>  53

Ala Ala Val Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  54
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1147V

<400>  54

Ala Ala Ala Val Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  55
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1154V

<400>  55

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Val Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  56
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1171V

<400>  56

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Val Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  57
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1173V

<400>  57

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Val Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  58
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1175V

<400>  58

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Val 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  59
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1180V

<400>  59

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Val Gly Pro 
        35                  


<210>  60
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1182V

<400>  60

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Val 
        35                  


<210>  61
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation A1144V

<400>  61

Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro 
1               5                   10                  15      


Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr 
            20                  25                  30          


Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala 
        35                  40                  45              


Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu 
    50                  55                  60                  


Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val 
65                  70                  75                  80  


Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly 
                85                  90                  95      


His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro 
            100                 105                 110         


Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys 
        115                 120                 125             


Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu 
    130                 135                 140                 


Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His 
145                 150                 155                 160 


Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala 
                165                 170                 175     


Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser 
            180                 185                 190         


Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val 
        195                 200                 205             


Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp 
    210                 215                 220                 


Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala 
225                 230                 235                 240 


Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp 
                245                 250                 255     


Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser 
            260                 265                 270         


Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val 
        275                 280                 285             


Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr 
    290                 295                 300                 


Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser 
305                 310                 315                 320 


Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln 
                325                 330                 335     


Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala 
            340                 345                 350         


Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln 
        355                 360                 365             


Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu 
    370                 375                 380                 


Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val 
385                 390                 395                 400 


Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile 
                405                 410                 415     


Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr 
            420                 425                 430         


Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys 
        435                 440                 445             


Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser 
    450                 455                 460                 


Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr 
465                 470                 475                 480 


Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr 
                485                 490                 495     


Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala 
            500                 505                 510         


Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg 
        515                 520                 525             


Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
    530                 535                 540                 


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu 
545                 550                 555                 560 


Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln 
                565                 570                 575     


Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly 
            580                 585                 590         


Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro 
        595                 600                 605             


Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser 
    610                 615                 620                 


Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala 
625                 630                 635                 640 


Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro 
                645                 650                 655     


Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp 
            660                 665                 670         


Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu 
        675                 680                 685             


Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys 
    690                 695                 700                 


Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val 
705                 710                 715                 720 


Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val 
                725                 730                 735     


Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu 
            740                 745                 750         


Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val 
        755                 760                 765             


Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro 
    770                 775                 780                 


Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr 
785                 790                 795                 800 


Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly 
                805                 810                 815     


Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val 
            820                 825                 830         


Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser 
        835                 840                 845             


Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys 
    850                 855                 860                 


Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg 
865                 870                 875                 880 


Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val 
                885                 890                 895     


Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly 
            900                 905                 910         


Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu 
        915                 920                 925             


Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val 
    930                 935                 940                 


Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg 
945                 950                 955                 960 


Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val 
                965                 970                 975     


Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro 
            980                 985                 990         


Cys Leu Ile Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
        995                 1000                 1005             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1010                 1015                 1020             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1025                 1030                 1035             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1040                 1045                 1050             


Gly Pro  Cys Val Gly Gln Gly  Thr Pro Ser Leu Val  Pro His Glu 
    1055                 1060                 1065             


Glu Val  Ala Ala Pro Gly Arg  Thr Thr Ala Thr Pro  Ala Gly Ala 
    1070                 1075                 1080             


Ser Leu  Glu Trp Ser Gln Ala  Arg Gly Leu Leu Phe  Ser Pro Ala 
    1085                 1090                 1095             


Pro Gln  Pro Arg Arg Leu Leu  Pro Gly Pro Gln Glu  Asn Ser Val 
    1100                 1105                 1110             


Gln Ser  Ser Ala Cys Gly Arg  Gln His Leu Glu Pro  Thr Gly Thr 
    1115                 1120                 1125             


Ile Asp  Met Arg Gly Pro Gly  Gln Ala Asp Cys Ala  Val Ala Ile 
    1130                 1135                 1140             


Gly Arg  Pro Leu Gly Glu Val  Val Thr Leu Arg Val  Leu Glu Ser 
    1145                 1150                 1155             


Ser Leu  Asn Cys Ser Ala Gly  Asp Met Leu Leu Leu  Trp Gly Arg 
    1160                 1165                 1170             


Leu Thr  Trp Arg Lys Met Cys  Arg Lys Leu Leu Asp  Met Thr Phe 
    1175                 1180                 1185             


Ser Ser  Lys Thr Asn Thr Leu  Val Val Arg Gln Arg  Cys Gly Arg 
    1190                 1195                 1200             


Pro Gly  Gly Gly Val Leu Leu  Arg Tyr Gly Ser Gln  Leu Ala Pro 
    1205                 1210                 1215             


Glu Thr  Phe Tyr Arg Glu Cys  Asp Met Gln Leu Phe  Gly Pro Trp 
    1220                 1225                 1230             


Gly Glu  Ile Val Ser Pro Ser  Leu Ser Pro Ala Thr  Ser Asn Ala 
    1235                 1240                 1245             


Gly Gly  Cys Arg Leu Phe Ile  Asn Val Ala Pro His  Ala Arg Ile 
    1250                 1255                 1260             


Ala Ile  His Ala Leu Ala Thr  Asn Met Gly Ala Gly  Thr Glu Gly 
    1265                 1270                 1275             


Ala Asn  Ala Ser Tyr Ile Leu  Ile Arg Asp Thr His  Ser Leu Arg 
    1280                 1285                 1290             


Thr Thr  Ala Phe His Gly Gln  Gln Val Leu Tyr Trp  Glu Ser Glu 
    1295                 1300                 1305             


Ser Ser  Gln Ala Glu Met Glu  Phe Ser Glu Gly Phe  Leu Lys Ala 
    1310                 1315                 1320             


Gln Ala  Ser Leu Arg Gly Gln  Tyr Trp Thr Leu Gln  Ser Trp Val 
    1325                 1330                 1335             


Pro Glu  Met Gln Asp Pro Gln  Ser Trp Lys Gly Lys  Glu Gly Thr 
    1340                 1345                 1350             


<210>  62
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation A1145V

<400>  62

Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro 
1               5                   10                  15      


Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr 
            20                  25                  30          


Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala 
        35                  40                  45              


Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu 
    50                  55                  60                  


Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val 
65                  70                  75                  80  


Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly 
                85                  90                  95      


His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro 
            100                 105                 110         


Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys 
        115                 120                 125             


Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu 
    130                 135                 140                 


Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His 
145                 150                 155                 160 


Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala 
                165                 170                 175     


Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser 
            180                 185                 190         


Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val 
        195                 200                 205             


Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp 
    210                 215                 220                 


Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala 
225                 230                 235                 240 


Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp 
                245                 250                 255     


Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser 
            260                 265                 270         


Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val 
        275                 280                 285             


Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr 
    290                 295                 300                 


Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser 
305                 310                 315                 320 


Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln 
                325                 330                 335     


Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala 
            340                 345                 350         


Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln 
        355                 360                 365             


Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu 
    370                 375                 380                 


Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val 
385                 390                 395                 400 


Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile 
                405                 410                 415     


Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr 
            420                 425                 430         


Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys 
        435                 440                 445             


Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser 
    450                 455                 460                 


Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr 
465                 470                 475                 480 


Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr 
                485                 490                 495     


Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala 
            500                 505                 510         


Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg 
        515                 520                 525             


Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
    530                 535                 540                 


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu 
545                 550                 555                 560 


Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln 
                565                 570                 575     


Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly 
            580                 585                 590         


Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro 
        595                 600                 605             


Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser 
    610                 615                 620                 


Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala 
625                 630                 635                 640 


Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro 
                645                 650                 655     


Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp 
            660                 665                 670         


Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu 
        675                 680                 685             


Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys 
    690                 695                 700                 


Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val 
705                 710                 715                 720 


Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val 
                725                 730                 735     


Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu 
            740                 745                 750         


Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val 
        755                 760                 765             


Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro 
    770                 775                 780                 


Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr 
785                 790                 795                 800 


Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly 
                805                 810                 815     


Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val 
            820                 825                 830         


Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser 
        835                 840                 845             


Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys 
    850                 855                 860                 


Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg 
865                 870                 875                 880 


Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val 
                885                 890                 895     


Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly 
            900                 905                 910         


Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu 
        915                 920                 925             


Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val 
    930                 935                 940                 


Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg 
945                 950                 955                 960 


Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val 
                965                 970                 975     


Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro 
            980                 985                 990         


Cys Leu Ile Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
        995                 1000                 1005             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1010                 1015                 1020             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1025                 1030                 1035             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1040                 1045                 1050             


Gly Pro  Cys Val Gly Gln Gly  Thr Pro Ser Leu Val  Pro His Glu 
    1055                 1060                 1065             


Glu Ala  Val Ala Pro Gly Arg  Thr Thr Ala Thr Pro  Ala Gly Ala 
    1070                 1075                 1080             


Ser Leu  Glu Trp Ser Gln Ala  Arg Gly Leu Leu Phe  Ser Pro Ala 
    1085                 1090                 1095             


Pro Gln  Pro Arg Arg Leu Leu  Pro Gly Pro Gln Glu  Asn Ser Val 
    1100                 1105                 1110             


Gln Ser  Ser Ala Cys Gly Arg  Gln His Leu Glu Pro  Thr Gly Thr 
    1115                 1120                 1125             


Ile Asp  Met Arg Gly Pro Gly  Gln Ala Asp Cys Ala  Val Ala Ile 
    1130                 1135                 1140             


Gly Arg  Pro Leu Gly Glu Val  Val Thr Leu Arg Val  Leu Glu Ser 
    1145                 1150                 1155             


Ser Leu  Asn Cys Ser Ala Gly  Asp Met Leu Leu Leu  Trp Gly Arg 
    1160                 1165                 1170             


Leu Thr  Trp Arg Lys Met Cys  Arg Lys Leu Leu Asp  Met Thr Phe 
    1175                 1180                 1185             


Ser Ser  Lys Thr Asn Thr Leu  Val Val Arg Gln Arg  Cys Gly Arg 
    1190                 1195                 1200             


Pro Gly  Gly Gly Val Leu Leu  Arg Tyr Gly Ser Gln  Leu Ala Pro 
    1205                 1210                 1215             


Glu Thr  Phe Tyr Arg Glu Cys  Asp Met Gln Leu Phe  Gly Pro Trp 
    1220                 1225                 1230             


Gly Glu  Ile Val Ser Pro Ser  Leu Ser Pro Ala Thr  Ser Asn Ala 
    1235                 1240                 1245             


Gly Gly  Cys Arg Leu Phe Ile  Asn Val Ala Pro His  Ala Arg Ile 
    1250                 1255                 1260             


Ala Ile  His Ala Leu Ala Thr  Asn Met Gly Ala Gly  Thr Glu Gly 
    1265                 1270                 1275             


Ala Asn  Ala Ser Tyr Ile Leu  Ile Arg Asp Thr His  Ser Leu Arg 
    1280                 1285                 1290             


Thr Thr  Ala Phe His Gly Gln  Gln Val Leu Tyr Trp  Glu Ser Glu 
    1295                 1300                 1305             


Ser Ser  Gln Ala Glu Met Glu  Phe Ser Glu Gly Phe  Leu Lys Ala 
    1310                 1315                 1320             


Gln Ala  Ser Leu Arg Gly Gln  Tyr Trp Thr Leu Gln  Ser Trp Val 
    1325                 1330                 1335             


Pro Glu  Met Gln Asp Pro Gln  Ser Trp Lys Gly Lys  Glu Gly Thr 
    1340                 1345                 1350             


<210>  63
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation A1146V

<400>  63

Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro 
1               5                   10                  15      


Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr 
            20                  25                  30          


Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala 
        35                  40                  45              


Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu 
    50                  55                  60                  


Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val 
65                  70                  75                  80  


Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly 
                85                  90                  95      


His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro 
            100                 105                 110         


Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys 
        115                 120                 125             


Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu 
    130                 135                 140                 


Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His 
145                 150                 155                 160 


Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala 
                165                 170                 175     


Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser 
            180                 185                 190         


Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val 
        195                 200                 205             


Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp 
    210                 215                 220                 


Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala 
225                 230                 235                 240 


Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp 
                245                 250                 255     


Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser 
            260                 265                 270         


Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val 
        275                 280                 285             


Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr 
    290                 295                 300                 


Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser 
305                 310                 315                 320 


Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln 
                325                 330                 335     


Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala 
            340                 345                 350         


Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln 
        355                 360                 365             


Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu 
    370                 375                 380                 


Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val 
385                 390                 395                 400 


Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile 
                405                 410                 415     


Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr 
            420                 425                 430         


Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys 
        435                 440                 445             


Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser 
    450                 455                 460                 


Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr 
465                 470                 475                 480 


Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr 
                485                 490                 495     


Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala 
            500                 505                 510         


Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg 
        515                 520                 525             


Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
    530                 535                 540                 


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu 
545                 550                 555                 560 


Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln 
                565                 570                 575     


Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly 
            580                 585                 590         


Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro 
        595                 600                 605             


Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser 
    610                 615                 620                 


Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala 
625                 630                 635                 640 


Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro 
                645                 650                 655     


Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp 
            660                 665                 670         


Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu 
        675                 680                 685             


Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys 
    690                 695                 700                 


Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val 
705                 710                 715                 720 


Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val 
                725                 730                 735     


Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu 
            740                 745                 750         


Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val 
        755                 760                 765             


Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro 
    770                 775                 780                 


Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr 
785                 790                 795                 800 


Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly 
                805                 810                 815     


Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val 
            820                 825                 830         


Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser 
        835                 840                 845             


Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys 
    850                 855                 860                 


Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg 
865                 870                 875                 880 


Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val 
                885                 890                 895     


Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly 
            900                 905                 910         


Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu 
        915                 920                 925             


Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val 
    930                 935                 940                 


Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg 
945                 950                 955                 960 


Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val 
                965                 970                 975     


Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro 
            980                 985                 990         


Cys Leu Ile Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
        995                 1000                 1005             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1010                 1015                 1020             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1025                 1030                 1035             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1040                 1045                 1050             


Gly Pro  Cys Val Gly Gln Gly  Thr Pro Ser Leu Val  Pro His Glu 
    1055                 1060                 1065             


Glu Ala  Ala Val Pro Gly Arg  Thr Thr Ala Thr Pro  Ala Gly Ala 
    1070                 1075                 1080             


Ser Leu  Glu Trp Ser Gln Ala  Arg Gly Leu Leu Phe  Ser Pro Ala 
    1085                 1090                 1095             


Pro Gln  Pro Arg Arg Leu Leu  Pro Gly Pro Gln Glu  Asn Ser Val 
    1100                 1105                 1110             


Gln Ser  Ser Ala Cys Gly Arg  Gln His Leu Glu Pro  Thr Gly Thr 
    1115                 1120                 1125             


Ile Asp  Met Arg Gly Pro Gly  Gln Ala Asp Cys Ala  Val Ala Ile 
    1130                 1135                 1140             


Gly Arg  Pro Leu Gly Glu Val  Val Thr Leu Arg Val  Leu Glu Ser 
    1145                 1150                 1155             


Ser Leu  Asn Cys Ser Ala Gly  Asp Met Leu Leu Leu  Trp Gly Arg 
    1160                 1165                 1170             


Leu Thr  Trp Arg Lys Met Cys  Arg Lys Leu Leu Asp  Met Thr Phe 
    1175                 1180                 1185             


Ser Ser  Lys Thr Asn Thr Leu  Val Val Arg Gln Arg  Cys Gly Arg 
    1190                 1195                 1200             


Pro Gly  Gly Gly Val Leu Leu  Arg Tyr Gly Ser Gln  Leu Ala Pro 
    1205                 1210                 1215             


Glu Thr  Phe Tyr Arg Glu Cys  Asp Met Gln Leu Phe  Gly Pro Trp 
    1220                 1225                 1230             


Gly Glu  Ile Val Ser Pro Ser  Leu Ser Pro Ala Thr  Ser Asn Ala 
    1235                 1240                 1245             


Gly Gly  Cys Arg Leu Phe Ile  Asn Val Ala Pro His  Ala Arg Ile 
    1250                 1255                 1260             


Ala Ile  His Ala Leu Ala Thr  Asn Met Gly Ala Gly  Thr Glu Gly 
    1265                 1270                 1275             


Ala Asn  Ala Ser Tyr Ile Leu  Ile Arg Asp Thr His  Ser Leu Arg 
    1280                 1285                 1290             


Thr Thr  Ala Phe His Gly Gln  Gln Val Leu Tyr Trp  Glu Ser Glu 
    1295                 1300                 1305             


Ser Ser  Gln Ala Glu Met Glu  Phe Ser Glu Gly Phe  Leu Lys Ala 
    1310                 1315                 1320             


Gln Ala  Ser Leu Arg Gly Gln  Tyr Trp Thr Leu Gln  Ser Trp Val 
    1325                 1330                 1335             


Pro Glu  Met Gln Asp Pro Gln  Ser Trp Lys Gly Lys  Glu Gly Thr 
    1340                 1345                 1350             


<210>  64
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1147V

<400>  64

Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro 
1               5                   10                  15      


Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr 
            20                  25                  30          


Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala 
        35                  40                  45              


Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu 
    50                  55                  60                  


Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val 
65                  70                  75                  80  


Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly 
                85                  90                  95      


His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro 
            100                 105                 110         


Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys 
        115                 120                 125             


Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu 
    130                 135                 140                 


Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His 
145                 150                 155                 160 


Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala 
                165                 170                 175     


Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser 
            180                 185                 190         


Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val 
        195                 200                 205             


Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp 
    210                 215                 220                 


Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala 
225                 230                 235                 240 


Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp 
                245                 250                 255     


Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser 
            260                 265                 270         


Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val 
        275                 280                 285             


Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr 
    290                 295                 300                 


Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser 
305                 310                 315                 320 


Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln 
                325                 330                 335     


Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala 
            340                 345                 350         


Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln 
        355                 360                 365             


Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu 
    370                 375                 380                 


Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val 
385                 390                 395                 400 


Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile 
                405                 410                 415     


Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr 
            420                 425                 430         


Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys 
        435                 440                 445             


Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser 
    450                 455                 460                 


Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr 
465                 470                 475                 480 


Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr 
                485                 490                 495     


Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala 
            500                 505                 510         


Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg 
        515                 520                 525             


Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
    530                 535                 540                 


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu 
545                 550                 555                 560 


Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln 
                565                 570                 575     


Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly 
            580                 585                 590         


Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro 
        595                 600                 605             


Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser 
    610                 615                 620                 


Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala 
625                 630                 635                 640 


Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro 
                645                 650                 655     


Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp 
            660                 665                 670         


Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu 
        675                 680                 685             


Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys 
    690                 695                 700                 


Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val 
705                 710                 715                 720 


Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val 
                725                 730                 735     


Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu 
            740                 745                 750         


Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val 
        755                 760                 765             


Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro 
    770                 775                 780                 


Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr 
785                 790                 795                 800 


Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly 
                805                 810                 815     


Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val 
            820                 825                 830         


Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser 
        835                 840                 845             


Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys 
    850                 855                 860                 


Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg 
865                 870                 875                 880 


Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val 
                885                 890                 895     


Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly 
            900                 905                 910         


Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu 
        915                 920                 925             


Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val 
    930                 935                 940                 


Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg 
945                 950                 955                 960 


Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val 
                965                 970                 975     


Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro 
            980                 985                 990         


Cys Leu Ile Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
        995                 1000                 1005             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1010                 1015                 1020             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1025                 1030                 1035             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1040                 1045                 1050             


Gly Pro  Cys Val Gly Gln Gly  Thr Pro Ser Leu Val  Pro His Glu 
    1055                 1060                 1065             


Glu Ala  Ala Ala Val Gly Arg  Thr Thr Ala Thr Pro  Ala Gly Ala 
    1070                 1075                 1080             


Ser Leu  Glu Trp Ser Gln Ala  Arg Gly Leu Leu Phe  Ser Pro Ala 
    1085                 1090                 1095             


Pro Gln  Pro Arg Arg Leu Leu  Pro Gly Pro Gln Glu  Asn Ser Val 
    1100                 1105                 1110             


Gln Ser  Ser Ala Cys Gly Arg  Gln His Leu Glu Pro  Thr Gly Thr 
    1115                 1120                 1125             


Ile Asp  Met Arg Gly Pro Gly  Gln Ala Asp Cys Ala  Val Ala Ile 
    1130                 1135                 1140             


Gly Arg  Pro Leu Gly Glu Val  Val Thr Leu Arg Val  Leu Glu Ser 
    1145                 1150                 1155             


Ser Leu  Asn Cys Ser Ala Gly  Asp Met Leu Leu Leu  Trp Gly Arg 
    1160                 1165                 1170             


Leu Thr  Trp Arg Lys Met Cys  Arg Lys Leu Leu Asp  Met Thr Phe 
    1175                 1180                 1185             


Ser Ser  Lys Thr Asn Thr Leu  Val Val Arg Gln Arg  Cys Gly Arg 
    1190                 1195                 1200             


Pro Gly  Gly Gly Val Leu Leu  Arg Tyr Gly Ser Gln  Leu Ala Pro 
    1205                 1210                 1215             


Glu Thr  Phe Tyr Arg Glu Cys  Asp Met Gln Leu Phe  Gly Pro Trp 
    1220                 1225                 1230             


Gly Glu  Ile Val Ser Pro Ser  Leu Ser Pro Ala Thr  Ser Asn Ala 
    1235                 1240                 1245             


Gly Gly  Cys Arg Leu Phe Ile  Asn Val Ala Pro His  Ala Arg Ile 
    1250                 1255                 1260             


Ala Ile  His Ala Leu Ala Thr  Asn Met Gly Ala Gly  Thr Glu Gly 
    1265                 1270                 1275             


Ala Asn  Ala Ser Tyr Ile Leu  Ile Arg Asp Thr His  Ser Leu Arg 
    1280                 1285                 1290             


Thr Thr  Ala Phe His Gly Gln  Gln Val Leu Tyr Trp  Glu Ser Glu 
    1295                 1300                 1305             


Ser Ser  Gln Ala Glu Met Glu  Phe Ser Glu Gly Phe  Leu Lys Ala 
    1310                 1315                 1320             


Gln Ala  Ser Leu Arg Gly Gln  Tyr Trp Thr Leu Gln  Ser Trp Val 
    1325                 1330                 1335             


Pro Glu  Met Gln Asp Pro Gln  Ser Trp Lys Gly Lys  Glu Gly Thr 
    1340                 1345                 1350             


<210>  65
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1154V

<400>  65

Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro 
1               5                   10                  15      


Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr 
            20                  25                  30          


Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala 
        35                  40                  45              


Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu 
    50                  55                  60                  


Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val 
65                  70                  75                  80  


Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly 
                85                  90                  95      


His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro 
            100                 105                 110         


Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys 
        115                 120                 125             


Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu 
    130                 135                 140                 


Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His 
145                 150                 155                 160 


Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala 
                165                 170                 175     


Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser 
            180                 185                 190         


Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val 
        195                 200                 205             


Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp 
    210                 215                 220                 


Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala 
225                 230                 235                 240 


Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp 
                245                 250                 255     


Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser 
            260                 265                 270         


Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val 
        275                 280                 285             


Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr 
    290                 295                 300                 


Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser 
305                 310                 315                 320 


Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln 
                325                 330                 335     


Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala 
            340                 345                 350         


Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln 
        355                 360                 365             


Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu 
    370                 375                 380                 


Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val 
385                 390                 395                 400 


Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile 
                405                 410                 415     


Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr 
            420                 425                 430         


Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys 
        435                 440                 445             


Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser 
    450                 455                 460                 


Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr 
465                 470                 475                 480 


Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr 
                485                 490                 495     


Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala 
            500                 505                 510         


Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg 
        515                 520                 525             


Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
    530                 535                 540                 


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu 
545                 550                 555                 560 


Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln 
                565                 570                 575     


Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly 
            580                 585                 590         


Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro 
        595                 600                 605             


Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser 
    610                 615                 620                 


Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala 
625                 630                 635                 640 


Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro 
                645                 650                 655     


Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp 
            660                 665                 670         


Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu 
        675                 680                 685             


Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys 
    690                 695                 700                 


Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val 
705                 710                 715                 720 


Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val 
                725                 730                 735     


Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu 
            740                 745                 750         


Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val 
        755                 760                 765             


Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro 
    770                 775                 780                 


Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr 
785                 790                 795                 800 


Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly 
                805                 810                 815     


Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val 
            820                 825                 830         


Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser 
        835                 840                 845             


Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys 
    850                 855                 860                 


Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg 
865                 870                 875                 880 


Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val 
                885                 890                 895     


Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly 
            900                 905                 910         


Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu 
        915                 920                 925             


Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val 
    930                 935                 940                 


Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg 
945                 950                 955                 960 


Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val 
                965                 970                 975     


Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro 
            980                 985                 990         


Cys Leu Ile Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
        995                 1000                 1005             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1010                 1015                 1020             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1025                 1030                 1035             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1040                 1045                 1050             


Gly Pro  Cys Val Gly Gln Gly  Thr Pro Ser Leu Val  Pro His Glu 
    1055                 1060                 1065             


Glu Ala  Ala Ala Pro Gly Arg  Thr Thr Ala Thr Val  Ala Gly Ala 
    1070                 1075                 1080             


Ser Leu  Glu Trp Ser Gln Ala  Arg Gly Leu Leu Phe  Ser Pro Ala 
    1085                 1090                 1095             


Pro Gln  Pro Arg Arg Leu Leu  Pro Gly Pro Gln Glu  Asn Ser Val 
    1100                 1105                 1110             


Gln Ser  Ser Ala Cys Gly Arg  Gln His Leu Glu Pro  Thr Gly Thr 
    1115                 1120                 1125             


Ile Asp  Met Arg Gly Pro Gly  Gln Ala Asp Cys Ala  Val Ala Ile 
    1130                 1135                 1140             


Gly Arg  Pro Leu Gly Glu Val  Val Thr Leu Arg Val  Leu Glu Ser 
    1145                 1150                 1155             


Ser Leu  Asn Cys Ser Ala Gly  Asp Met Leu Leu Leu  Trp Gly Arg 
    1160                 1165                 1170             


Leu Thr  Trp Arg Lys Met Cys  Arg Lys Leu Leu Asp  Met Thr Phe 
    1175                 1180                 1185             


Ser Ser  Lys Thr Asn Thr Leu  Val Val Arg Gln Arg  Cys Gly Arg 
    1190                 1195                 1200             


Pro Gly  Gly Gly Val Leu Leu  Arg Tyr Gly Ser Gln  Leu Ala Pro 
    1205                 1210                 1215             


Glu Thr  Phe Tyr Arg Glu Cys  Asp Met Gln Leu Phe  Gly Pro Trp 
    1220                 1225                 1230             


Gly Glu  Ile Val Ser Pro Ser  Leu Ser Pro Ala Thr  Ser Asn Ala 
    1235                 1240                 1245             


Gly Gly  Cys Arg Leu Phe Ile  Asn Val Ala Pro His  Ala Arg Ile 
    1250                 1255                 1260             


Ala Ile  His Ala Leu Ala Thr  Asn Met Gly Ala Gly  Thr Glu Gly 
    1265                 1270                 1275             


Ala Asn  Ala Ser Tyr Ile Leu  Ile Arg Asp Thr His  Ser Leu Arg 
    1280                 1285                 1290             


Thr Thr  Ala Phe His Gly Gln  Gln Val Leu Tyr Trp  Glu Ser Glu 
    1295                 1300                 1305             


Ser Ser  Gln Ala Glu Met Glu  Phe Ser Glu Gly Phe  Leu Lys Ala 
    1310                 1315                 1320             


Gln Ala  Ser Leu Arg Gly Gln  Tyr Trp Thr Leu Gln  Ser Trp Val 
    1325                 1330                 1335             


Pro Glu  Met Gln Asp Pro Gln  Ser Trp Lys Gly Lys  Glu Gly Thr 
    1340                 1345                 1350             


<210>  66
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1171V

<400>  66

Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro 
1               5                   10                  15      


Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr 
            20                  25                  30          


Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala 
        35                  40                  45              


Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu 
    50                  55                  60                  


Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val 
65                  70                  75                  80  


Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly 
                85                  90                  95      


His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro 
            100                 105                 110         


Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys 
        115                 120                 125             


Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu 
    130                 135                 140                 


Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His 
145                 150                 155                 160 


Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala 
                165                 170                 175     


Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser 
            180                 185                 190         


Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val 
        195                 200                 205             


Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp 
    210                 215                 220                 


Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala 
225                 230                 235                 240 


Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp 
                245                 250                 255     


Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser 
            260                 265                 270         


Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val 
        275                 280                 285             


Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr 
    290                 295                 300                 


Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser 
305                 310                 315                 320 


Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln 
                325                 330                 335     


Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala 
            340                 345                 350         


Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln 
        355                 360                 365             


Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu 
    370                 375                 380                 


Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val 
385                 390                 395                 400 


Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile 
                405                 410                 415     


Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr 
            420                 425                 430         


Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys 
        435                 440                 445             


Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser 
    450                 455                 460                 


Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr 
465                 470                 475                 480 


Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr 
                485                 490                 495     


Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala 
            500                 505                 510         


Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg 
        515                 520                 525             


Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
    530                 535                 540                 


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu 
545                 550                 555                 560 


Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln 
                565                 570                 575     


Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly 
            580                 585                 590         


Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro 
        595                 600                 605             


Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser 
    610                 615                 620                 


Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala 
625                 630                 635                 640 


Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro 
                645                 650                 655     


Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp 
            660                 665                 670         


Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu 
        675                 680                 685             


Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys 
    690                 695                 700                 


Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val 
705                 710                 715                 720 


Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val 
                725                 730                 735     


Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu 
            740                 745                 750         


Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val 
        755                 760                 765             


Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro 
    770                 775                 780                 


Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr 
785                 790                 795                 800 


Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly 
                805                 810                 815     


Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val 
            820                 825                 830         


Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser 
        835                 840                 845             


Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys 
    850                 855                 860                 


Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg 
865                 870                 875                 880 


Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val 
                885                 890                 895     


Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly 
            900                 905                 910         


Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu 
        915                 920                 925             


Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val 
    930                 935                 940                 


Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg 
945                 950                 955                 960 


Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val 
                965                 970                 975     


Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro 
            980                 985                 990         


Cys Leu Ile Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
        995                 1000                 1005             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1010                 1015                 1020             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1025                 1030                 1035             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1040                 1045                 1050             


Gly Pro  Cys Val Gly Gln Gly  Thr Pro Ser Leu Val  Pro His Glu 
    1055                 1060                 1065             


Glu Ala  Ala Ala Pro Gly Arg  Thr Thr Ala Thr Pro  Ala Gly Ala 
    1070                 1075                 1080             


Ser Leu  Glu Trp Ser Gln Ala  Arg Gly Leu Leu Phe  Ser Val Ala 
    1085                 1090                 1095             


Pro Gln  Pro Arg Arg Leu Leu  Pro Gly Pro Gln Glu  Asn Ser Val 
    1100                 1105                 1110             


Gln Ser  Ser Ala Cys Gly Arg  Gln His Leu Glu Pro  Thr Gly Thr 
    1115                 1120                 1125             


Ile Asp  Met Arg Gly Pro Gly  Gln Ala Asp Cys Ala  Val Ala Ile 
    1130                 1135                 1140             


Gly Arg  Pro Leu Gly Glu Val  Val Thr Leu Arg Val  Leu Glu Ser 
    1145                 1150                 1155             


Ser Leu  Asn Cys Ser Ala Gly  Asp Met Leu Leu Leu  Trp Gly Arg 
    1160                 1165                 1170             


Leu Thr  Trp Arg Lys Met Cys  Arg Lys Leu Leu Asp  Met Thr Phe 
    1175                 1180                 1185             


Ser Ser  Lys Thr Asn Thr Leu  Val Val Arg Gln Arg  Cys Gly Arg 
    1190                 1195                 1200             


Pro Gly  Gly Gly Val Leu Leu  Arg Tyr Gly Ser Gln  Leu Ala Pro 
    1205                 1210                 1215             


Glu Thr  Phe Tyr Arg Glu Cys  Asp Met Gln Leu Phe  Gly Pro Trp 
    1220                 1225                 1230             


Gly Glu  Ile Val Ser Pro Ser  Leu Ser Pro Ala Thr  Ser Asn Ala 
    1235                 1240                 1245             


Gly Gly  Cys Arg Leu Phe Ile  Asn Val Ala Pro His  Ala Arg Ile 
    1250                 1255                 1260             


Ala Ile  His Ala Leu Ala Thr  Asn Met Gly Ala Gly  Thr Glu Gly 
    1265                 1270                 1275             


Ala Asn  Ala Ser Tyr Ile Leu  Ile Arg Asp Thr His  Ser Leu Arg 
    1280                 1285                 1290             


Thr Thr  Ala Phe His Gly Gln  Gln Val Leu Tyr Trp  Glu Ser Glu 
    1295                 1300                 1305             


Ser Ser  Gln Ala Glu Met Glu  Phe Ser Glu Gly Phe  Leu Lys Ala 
    1310                 1315                 1320             


Gln Ala  Ser Leu Arg Gly Gln  Tyr Trp Thr Leu Gln  Ser Trp Val 
    1325                 1330                 1335             


Pro Glu  Met Gln Asp Pro Gln  Ser Trp Lys Gly Lys  Glu Gly Thr 
    1340                 1345                 1350             


<210>  67
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1173V

<400>  67

Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro 
1               5                   10                  15      


Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr 
            20                  25                  30          


Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala 
        35                  40                  45              


Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu 
    50                  55                  60                  


Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val 
65                  70                  75                  80  


Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly 
                85                  90                  95      


His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro 
            100                 105                 110         


Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys 
        115                 120                 125             


Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu 
    130                 135                 140                 


Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His 
145                 150                 155                 160 


Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala 
                165                 170                 175     


Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser 
            180                 185                 190         


Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val 
        195                 200                 205             


Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp 
    210                 215                 220                 


Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala 
225                 230                 235                 240 


Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp 
                245                 250                 255     


Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser 
            260                 265                 270         


Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val 
        275                 280                 285             


Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr 
    290                 295                 300                 


Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser 
305                 310                 315                 320 


Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln 
                325                 330                 335     


Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala 
            340                 345                 350         


Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln 
        355                 360                 365             


Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu 
    370                 375                 380                 


Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val 
385                 390                 395                 400 


Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile 
                405                 410                 415     


Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr 
            420                 425                 430         


Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys 
        435                 440                 445             


Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser 
    450                 455                 460                 


Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr 
465                 470                 475                 480 


Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr 
                485                 490                 495     


Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala 
            500                 505                 510         


Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg 
        515                 520                 525             


Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
    530                 535                 540                 


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu 
545                 550                 555                 560 


Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln 
                565                 570                 575     


Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly 
            580                 585                 590         


Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro 
        595                 600                 605             


Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser 
    610                 615                 620                 


Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala 
625                 630                 635                 640 


Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro 
                645                 650                 655     


Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp 
            660                 665                 670         


Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu 
        675                 680                 685             


Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys 
    690                 695                 700                 


Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val 
705                 710                 715                 720 


Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val 
                725                 730                 735     


Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu 
            740                 745                 750         


Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val 
        755                 760                 765             


Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro 
    770                 775                 780                 


Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr 
785                 790                 795                 800 


Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly 
                805                 810                 815     


Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val 
            820                 825                 830         


Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser 
        835                 840                 845             


Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys 
    850                 855                 860                 


Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg 
865                 870                 875                 880 


Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val 
                885                 890                 895     


Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly 
            900                 905                 910         


Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu 
        915                 920                 925             


Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val 
    930                 935                 940                 


Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg 
945                 950                 955                 960 


Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val 
                965                 970                 975     


Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro 
            980                 985                 990         


Cys Leu Ile Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
        995                 1000                 1005             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1010                 1015                 1020             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1025                 1030                 1035             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1040                 1045                 1050             


Gly Pro  Cys Val Gly Gln Gly  Thr Pro Ser Leu Val  Pro His Glu 
    1055                 1060                 1065             


Glu Ala  Ala Ala Pro Gly Arg  Thr Thr Ala Thr Pro  Ala Gly Ala 
    1070                 1075                 1080             


Ser Leu  Glu Trp Ser Gln Ala  Arg Gly Leu Leu Phe  Ser Pro Ala 
    1085                 1090                 1095             


Val Gln  Pro Arg Arg Leu Leu  Pro Gly Pro Gln Glu  Asn Ser Val 
    1100                 1105                 1110             


Gln Ser  Ser Ala Cys Gly Arg  Gln His Leu Glu Pro  Thr Gly Thr 
    1115                 1120                 1125             


Ile Asp  Met Arg Gly Pro Gly  Gln Ala Asp Cys Ala  Val Ala Ile 
    1130                 1135                 1140             


Gly Arg  Pro Leu Gly Glu Val  Val Thr Leu Arg Val  Leu Glu Ser 
    1145                 1150                 1155             


Ser Leu  Asn Cys Ser Ala Gly  Asp Met Leu Leu Leu  Trp Gly Arg 
    1160                 1165                 1170             


Leu Thr  Trp Arg Lys Met Cys  Arg Lys Leu Leu Asp  Met Thr Phe 
    1175                 1180                 1185             


Ser Ser  Lys Thr Asn Thr Leu  Val Val Arg Gln Arg  Cys Gly Arg 
    1190                 1195                 1200             


Pro Gly  Gly Gly Val Leu Leu  Arg Tyr Gly Ser Gln  Leu Ala Pro 
    1205                 1210                 1215             


Glu Thr  Phe Tyr Arg Glu Cys  Asp Met Gln Leu Phe  Gly Pro Trp 
    1220                 1225                 1230             


Gly Glu  Ile Val Ser Pro Ser  Leu Ser Pro Ala Thr  Ser Asn Ala 
    1235                 1240                 1245             


Gly Gly  Cys Arg Leu Phe Ile  Asn Val Ala Pro His  Ala Arg Ile 
    1250                 1255                 1260             


Ala Ile  His Ala Leu Ala Thr  Asn Met Gly Ala Gly  Thr Glu Gly 
    1265                 1270                 1275             


Ala Asn  Ala Ser Tyr Ile Leu  Ile Arg Asp Thr His  Ser Leu Arg 
    1280                 1285                 1290             


Thr Thr  Ala Phe His Gly Gln  Gln Val Leu Tyr Trp  Glu Ser Glu 
    1295                 1300                 1305             


Ser Ser  Gln Ala Glu Met Glu  Phe Ser Glu Gly Phe  Leu Lys Ala 
    1310                 1315                 1320             


Gln Ala  Ser Leu Arg Gly Gln  Tyr Trp Thr Leu Gln  Ser Trp Val 
    1325                 1330                 1335             


Pro Glu  Met Gln Asp Pro Gln  Ser Trp Lys Gly Lys  Glu Gly Thr 
    1340                 1345                 1350             


<210>  68
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1175V

<400>  68

Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro 
1               5                   10                  15      


Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr 
            20                  25                  30          


Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala 
        35                  40                  45              


Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu 
    50                  55                  60                  


Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val 
65                  70                  75                  80  


Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly 
                85                  90                  95      


His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro 
            100                 105                 110         


Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys 
        115                 120                 125             


Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu 
    130                 135                 140                 


Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His 
145                 150                 155                 160 


Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala 
                165                 170                 175     


Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser 
            180                 185                 190         


Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val 
        195                 200                 205             


Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp 
    210                 215                 220                 


Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala 
225                 230                 235                 240 


Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp 
                245                 250                 255     


Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser 
            260                 265                 270         


Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val 
        275                 280                 285             


Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr 
    290                 295                 300                 


Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser 
305                 310                 315                 320 


Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln 
                325                 330                 335     


Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala 
            340                 345                 350         


Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln 
        355                 360                 365             


Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu 
    370                 375                 380                 


Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val 
385                 390                 395                 400 


Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile 
                405                 410                 415     


Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr 
            420                 425                 430         


Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys 
        435                 440                 445             


Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser 
    450                 455                 460                 


Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr 
465                 470                 475                 480 


Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr 
                485                 490                 495     


Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala 
            500                 505                 510         


Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg 
        515                 520                 525             


Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
    530                 535                 540                 


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu 
545                 550                 555                 560 


Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln 
                565                 570                 575     


Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly 
            580                 585                 590         


Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro 
        595                 600                 605             


Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser 
    610                 615                 620                 


Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala 
625                 630                 635                 640 


Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro 
                645                 650                 655     


Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp 
            660                 665                 670         


Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu 
        675                 680                 685             


Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys 
    690                 695                 700                 


Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val 
705                 710                 715                 720 


Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val 
                725                 730                 735     


Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu 
            740                 745                 750         


Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val 
        755                 760                 765             


Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro 
    770                 775                 780                 


Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr 
785                 790                 795                 800 


Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly 
                805                 810                 815     


Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val 
            820                 825                 830         


Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser 
        835                 840                 845             


Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys 
    850                 855                 860                 


Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg 
865                 870                 875                 880 


Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val 
                885                 890                 895     


Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly 
            900                 905                 910         


Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu 
        915                 920                 925             


Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val 
    930                 935                 940                 


Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg 
945                 950                 955                 960 


Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val 
                965                 970                 975     


Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro 
            980                 985                 990         


Cys Leu Ile Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
        995                 1000                 1005             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1010                 1015                 1020             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1025                 1030                 1035             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1040                 1045                 1050             


Gly Pro  Cys Val Gly Gln Gly  Thr Pro Ser Leu Val  Pro His Glu 
    1055                 1060                 1065             


Glu Ala  Ala Ala Pro Gly Arg  Thr Thr Ala Thr Pro  Ala Gly Ala 
    1070                 1075                 1080             


Ser Leu  Glu Trp Ser Gln Ala  Arg Gly Leu Leu Phe  Ser Pro Ala 
    1085                 1090                 1095             


Pro Gln  Val Arg Arg Leu Leu  Pro Gly Pro Gln Glu  Asn Ser Val 
    1100                 1105                 1110             


Gln Ser  Ser Ala Cys Gly Arg  Gln His Leu Glu Pro  Thr Gly Thr 
    1115                 1120                 1125             


Ile Asp  Met Arg Gly Pro Gly  Gln Ala Asp Cys Ala  Val Ala Ile 
    1130                 1135                 1140             


Gly Arg  Pro Leu Gly Glu Val  Val Thr Leu Arg Val  Leu Glu Ser 
    1145                 1150                 1155             


Ser Leu  Asn Cys Ser Ala Gly  Asp Met Leu Leu Leu  Trp Gly Arg 
    1160                 1165                 1170             


Leu Thr  Trp Arg Lys Met Cys  Arg Lys Leu Leu Asp  Met Thr Phe 
    1175                 1180                 1185             


Ser Ser  Lys Thr Asn Thr Leu  Val Val Arg Gln Arg  Cys Gly Arg 
    1190                 1195                 1200             


Pro Gly  Gly Gly Val Leu Leu  Arg Tyr Gly Ser Gln  Leu Ala Pro 
    1205                 1210                 1215             


Glu Thr  Phe Tyr Arg Glu Cys  Asp Met Gln Leu Phe  Gly Pro Trp 
    1220                 1225                 1230             


Gly Glu  Ile Val Ser Pro Ser  Leu Ser Pro Ala Thr  Ser Asn Ala 
    1235                 1240                 1245             


Gly Gly  Cys Arg Leu Phe Ile  Asn Val Ala Pro His  Ala Arg Ile 
    1250                 1255                 1260             


Ala Ile  His Ala Leu Ala Thr  Asn Met Gly Ala Gly  Thr Glu Gly 
    1265                 1270                 1275             


Ala Asn  Ala Ser Tyr Ile Leu  Ile Arg Asp Thr His  Ser Leu Arg 
    1280                 1285                 1290             


Thr Thr  Ala Phe His Gly Gln  Gln Val Leu Tyr Trp  Glu Ser Glu 
    1295                 1300                 1305             


Ser Ser  Gln Ala Glu Met Glu  Phe Ser Glu Gly Phe  Leu Lys Ala 
    1310                 1315                 1320             


Gln Ala  Ser Leu Arg Gly Gln  Tyr Trp Thr Leu Gln  Ser Trp Val 
    1325                 1330                 1335             


Pro Glu  Met Gln Asp Pro Gln  Ser Trp Lys Gly Lys  Glu Gly Thr 
    1340                 1345                 1350             


<210>  69
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1180V

<400>  69

Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro 
1               5                   10                  15      


Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr 
            20                  25                  30          


Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala 
        35                  40                  45              


Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu 
    50                  55                  60                  


Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val 
65                  70                  75                  80  


Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly 
                85                  90                  95      


His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro 
            100                 105                 110         


Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys 
        115                 120                 125             


Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu 
    130                 135                 140                 


Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His 
145                 150                 155                 160 


Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala 
                165                 170                 175     


Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser 
            180                 185                 190         


Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val 
        195                 200                 205             


Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp 
    210                 215                 220                 


Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala 
225                 230                 235                 240 


Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp 
                245                 250                 255     


Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser 
            260                 265                 270         


Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val 
        275                 280                 285             


Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr 
    290                 295                 300                 


Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser 
305                 310                 315                 320 


Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln 
                325                 330                 335     


Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala 
            340                 345                 350         


Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln 
        355                 360                 365             


Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu 
    370                 375                 380                 


Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val 
385                 390                 395                 400 


Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile 
                405                 410                 415     


Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr 
            420                 425                 430         


Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys 
        435                 440                 445             


Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser 
    450                 455                 460                 


Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr 
465                 470                 475                 480 


Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr 
                485                 490                 495     


Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala 
            500                 505                 510         


Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg 
        515                 520                 525             


Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
    530                 535                 540                 


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu 
545                 550                 555                 560 


Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln 
                565                 570                 575     


Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly 
            580                 585                 590         


Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro 
        595                 600                 605             


Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser 
    610                 615                 620                 


Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala 
625                 630                 635                 640 


Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro 
                645                 650                 655     


Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp 
            660                 665                 670         


Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu 
        675                 680                 685             


Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys 
    690                 695                 700                 


Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val 
705                 710                 715                 720 


Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val 
                725                 730                 735     


Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu 
            740                 745                 750         


Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val 
        755                 760                 765             


Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro 
    770                 775                 780                 


Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr 
785                 790                 795                 800 


Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly 
                805                 810                 815     


Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val 
            820                 825                 830         


Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser 
        835                 840                 845             


Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys 
    850                 855                 860                 


Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg 
865                 870                 875                 880 


Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val 
                885                 890                 895     


Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly 
            900                 905                 910         


Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu 
        915                 920                 925             


Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val 
    930                 935                 940                 


Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg 
945                 950                 955                 960 


Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val 
                965                 970                 975     


Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro 
            980                 985                 990         


Cys Leu Ile Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
        995                 1000                 1005             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1010                 1015                 1020             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1025                 1030                 1035             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1040                 1045                 1050             


Gly Pro  Cys Val Gly Gln Gly  Thr Pro Ser Leu Val  Pro His Glu 
    1055                 1060                 1065             


Glu Ala  Ala Ala Pro Gly Arg  Thr Thr Ala Thr Pro  Ala Gly Ala 
    1070                 1075                 1080             


Ser Leu  Glu Trp Ser Gln Ala  Arg Gly Leu Leu Phe  Ser Pro Ala 
    1085                 1090                 1095             


Pro Gln  Pro Arg Arg Leu Leu  Val Gly Pro Gln Glu  Asn Ser Val 
    1100                 1105                 1110             


Gln Ser  Ser Ala Cys Gly Arg  Gln His Leu Glu Pro  Thr Gly Thr 
    1115                 1120                 1125             


Ile Asp  Met Arg Gly Pro Gly  Gln Ala Asp Cys Ala  Val Ala Ile 
    1130                 1135                 1140             


Gly Arg  Pro Leu Gly Glu Val  Val Thr Leu Arg Val  Leu Glu Ser 
    1145                 1150                 1155             


Ser Leu  Asn Cys Ser Ala Gly  Asp Met Leu Leu Leu  Trp Gly Arg 
    1160                 1165                 1170             


Leu Thr  Trp Arg Lys Met Cys  Arg Lys Leu Leu Asp  Met Thr Phe 
    1175                 1180                 1185             


Ser Ser  Lys Thr Asn Thr Leu  Val Val Arg Gln Arg  Cys Gly Arg 
    1190                 1195                 1200             


Pro Gly  Gly Gly Val Leu Leu  Arg Tyr Gly Ser Gln  Leu Ala Pro 
    1205                 1210                 1215             


Glu Thr  Phe Tyr Arg Glu Cys  Asp Met Gln Leu Phe  Gly Pro Trp 
    1220                 1225                 1230             


Gly Glu  Ile Val Ser Pro Ser  Leu Ser Pro Ala Thr  Ser Asn Ala 
    1235                 1240                 1245             


Gly Gly  Cys Arg Leu Phe Ile  Asn Val Ala Pro His  Ala Arg Ile 
    1250                 1255                 1260             


Ala Ile  His Ala Leu Ala Thr  Asn Met Gly Ala Gly  Thr Glu Gly 
    1265                 1270                 1275             


Ala Asn  Ala Ser Tyr Ile Leu  Ile Arg Asp Thr His  Ser Leu Arg 
    1280                 1285                 1290             


Thr Thr  Ala Phe His Gly Gln  Gln Val Leu Tyr Trp  Glu Ser Glu 
    1295                 1300                 1305             


Ser Ser  Gln Ala Glu Met Glu  Phe Ser Glu Gly Phe  Leu Lys Ala 
    1310                 1315                 1320             


Gln Ala  Ser Leu Arg Gly Gln  Tyr Trp Thr Leu Gln  Ser Trp Val 
    1325                 1330                 1335             


Pro Glu  Met Gln Asp Pro Gln  Ser Trp Lys Gly Lys  Glu Gly Thr 
    1340                 1345                 1350             


<210>  70
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1182V

<400>  70

Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro 
1               5                   10                  15      


Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr 
            20                  25                  30          


Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala 
        35                  40                  45              


Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu 
    50                  55                  60                  


Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val 
65                  70                  75                  80  


Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly 
                85                  90                  95      


His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro 
            100                 105                 110         


Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys 
        115                 120                 125             


Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu 
    130                 135                 140                 


Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His 
145                 150                 155                 160 


Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala 
                165                 170                 175     


Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser 
            180                 185                 190         


Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val 
        195                 200                 205             


Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp 
    210                 215                 220                 


Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala 
225                 230                 235                 240 


Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp 
                245                 250                 255     


Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser 
            260                 265                 270         


Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val 
        275                 280                 285             


Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr 
    290                 295                 300                 


Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser 
305                 310                 315                 320 


Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln 
                325                 330                 335     


Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala 
            340                 345                 350         


Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln 
        355                 360                 365             


Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu 
    370                 375                 380                 


Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val 
385                 390                 395                 400 


Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile 
                405                 410                 415     


Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr 
            420                 425                 430         


Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys 
        435                 440                 445             


Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser 
    450                 455                 460                 


Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr 
465                 470                 475                 480 


Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr 
                485                 490                 495     


Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala 
            500                 505                 510         


Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg 
        515                 520                 525             


Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
    530                 535                 540                 


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu 
545                 550                 555                 560 


Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln 
                565                 570                 575     


Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly 
            580                 585                 590         


Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro 
        595                 600                 605             


Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser 
    610                 615                 620                 


Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala 
625                 630                 635                 640 


Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro 
                645                 650                 655     


Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp 
            660                 665                 670         


Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu 
        675                 680                 685             


Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys 
    690                 695                 700                 


Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val 
705                 710                 715                 720 


Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val 
                725                 730                 735     


Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu 
            740                 745                 750         


Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val 
        755                 760                 765             


Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro 
    770                 775                 780                 


Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr 
785                 790                 795                 800 


Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly 
                805                 810                 815     


Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val 
            820                 825                 830         


Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser 
        835                 840                 845             


Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys 
    850                 855                 860                 


Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg 
865                 870                 875                 880 


Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val 
                885                 890                 895     


Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly 
            900                 905                 910         


Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu 
        915                 920                 925             


Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val 
    930                 935                 940                 


Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg 
945                 950                 955                 960 


Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val 
                965                 970                 975     


Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro 
            980                 985                 990         


Cys Leu Ile Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
        995                 1000                 1005             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1010                 1015                 1020             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1025                 1030                 1035             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1040                 1045                 1050             


Gly Pro  Cys Val Gly Gln Gly  Thr Pro Ser Leu Val  Pro His Glu 
    1055                 1060                 1065             


Glu Ala  Ala Ala Pro Gly Arg  Thr Thr Ala Thr Pro  Ala Gly Ala 
    1070                 1075                 1080             


Ser Leu  Glu Trp Ser Gln Ala  Arg Gly Leu Leu Phe  Ser Pro Ala 
    1085                 1090                 1095             


Pro Gln  Pro Arg Arg Leu Leu  Pro Gly Val Gln Glu  Asn Ser Val 
    1100                 1105                 1110             


Gln Ser  Ser Ala Cys Gly Arg  Gln His Leu Glu Pro  Thr Gly Thr 
    1115                 1120                 1125             


Ile Asp  Met Arg Gly Pro Gly  Gln Ala Asp Cys Ala  Val Ala Ile 
    1130                 1135                 1140             


Gly Arg  Pro Leu Gly Glu Val  Val Thr Leu Arg Val  Leu Glu Ser 
    1145                 1150                 1155             


Ser Leu  Asn Cys Ser Ala Gly  Asp Met Leu Leu Leu  Trp Gly Arg 
    1160                 1165                 1170             


Leu Thr  Trp Arg Lys Met Cys  Arg Lys Leu Leu Asp  Met Thr Phe 
    1175                 1180                 1185             


Ser Ser  Lys Thr Asn Thr Leu  Val Val Arg Gln Arg  Cys Gly Arg 
    1190                 1195                 1200             


Pro Gly  Gly Gly Val Leu Leu  Arg Tyr Gly Ser Gln  Leu Ala Pro 
    1205                 1210                 1215             


Glu Thr  Phe Tyr Arg Glu Cys  Asp Met Gln Leu Phe  Gly Pro Trp 
    1220                 1225                 1230             


Gly Glu  Ile Val Ser Pro Ser  Leu Ser Pro Ala Thr  Ser Asn Ala 
    1235                 1240                 1245             


Gly Gly  Cys Arg Leu Phe Ile  Asn Val Ala Pro His  Ala Arg Ile 
    1250                 1255                 1260             


Ala Ile  His Ala Leu Ala Thr  Asn Met Gly Ala Gly  Thr Glu Gly 
    1265                 1270                 1275             


Ala Asn  Ala Ser Tyr Ile Leu  Ile Arg Asp Thr His  Ser Leu Arg 
    1280                 1285                 1290             


Thr Thr  Ala Phe His Gly Gln  Gln Val Leu Tyr Trp  Glu Ser Glu 
    1295                 1300                 1305             


Ser Ser  Gln Ala Glu Met Glu  Phe Ser Glu Gly Phe  Leu Lys Ala 
    1310                 1315                 1320             


Gln Ala  Ser Leu Arg Gly Gln  Tyr Trp Thr Leu Gln  Ser Trp Val 
    1325                 1330                 1335             


Pro Glu  Met Gln Asp Pro Gln  Ser Trp Lys Gly Lys  Glu Gly Thr 
    1340                 1345                 1350             


<210>  71
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with point mutations 
       R568K/F592Y/R660K/Y661F/Y665F

<400>  71

Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly Pro 
1               5                   10                  15      


Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr 
            20                  25                  30          


Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala 
        35                  40                  45              


Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro Glu 
    50                  55                  60                  


Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser Val 
65                  70                  75                  80  


Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly 
                85                  90                  95      


His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro 
            100                 105                 110         


Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala Cys 
        115                 120                 125             


Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu 
    130                 135                 140                 


Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu His 
145                 150                 155                 160 


Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met Ala 
                165                 170                 175     


Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser 
            180                 185                 190         


Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys Val 
        195                 200                 205             


Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro Asp 
    210                 215                 220                 


Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala 
225                 230                 235                 240 


Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp 
                245                 250                 255     


Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser 
            260                 265                 270         


Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val 
        275                 280                 285             


Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr 
    290                 295                 300                 


Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser 
305                 310                 315                 320 


Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln 
                325                 330                 335     


Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala 
            340                 345                 350         


Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln 
        355                 360                 365             


Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu 
    370                 375                 380                 


Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val 
385                 390                 395                 400 


Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile 
                405                 410                 415     


Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr 
            420                 425                 430         


Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys 
        435                 440                 445             


Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser 
    450                 455                 460                 


Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr 
465                 470                 475                 480 


Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Lys Glu Tyr 
                485                 490                 495     


Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala 
            500                 505                 510         


Asn His Arg Pro Leu Tyr Thr His Leu Ala Val Arg Ile Gly Gly Arg 
        515                 520                 525             


Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
    530                 535                 540                 


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu 
545                 550                 555                 560 


Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln 
                565                 570                 575     


Glu Asp Ala Asp Ile Gln Val Tyr Arg Lys Phe Gly Glu Glu Phe Gly 
            580                 585                 590         


Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro 
        595                 600                 605             


Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser 
    610                 615                 620                 


Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala 
625                 630                 635                 640 


Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro 
                645                 650                 655     


Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp 
            660                 665                 670         


Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu 
        675                 680                 685             


Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys 
    690                 695                 700                 


Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val 
705                 710                 715                 720 


Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val 
                725                 730                 735     


Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu 
            740                 745                 750         


Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val 
        755                 760                 765             


Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro 
    770                 775                 780                 


Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr 
785                 790                 795                 800 


Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly 
                805                 810                 815     


Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val 
            820                 825                 830         


Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser 
        835                 840                 845             


Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys 
    850                 855                 860                 


Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg 
865                 870                 875                 880 


Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val 
                885                 890                 895     


Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly 
            900                 905                 910         


Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu 
        915                 920                 925             


Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val 
    930                 935                 940                 


Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg 
945                 950                 955                 960 


Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val 
                965                 970                 975     


Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro 
            980                 985                 990         


Cys Leu Ile Ala Asp Cys Thr Tyr  Arg Trp His Val Gly  Thr Trp Met 
        995                 1000                 1005             


Glu Cys  Ser Val Ser Cys Gly  Asp Gly Ile Gln Arg  Arg Arg Asp 
    1010                 1015                 1020             


Thr Cys  Leu Gly Pro Gln Ala  Gln Ala Pro Val Pro  Ala Asp Phe 
    1025                 1030                 1035             


Cys Gln  His Leu Pro Lys Pro  Val Thr Val Arg Gly  Cys Trp Ala 
    1040                 1045                 1050             


Gly Pro  Cys Val Gly Gln Gly  Thr Pro Ser Leu Val  Pro His Glu 
    1055                 1060                 1065             


Glu Ala  Ala Ala Pro Gly Arg  Thr Thr Ala Thr Pro  Ala Gly Ala 
    1070                 1075                 1080             


Ser Leu  Glu Trp Ser Gln Ala  Arg Gly Leu Leu Phe  Ser Pro Ala 
    1085                 1090                 1095             


Pro Gln  Pro Arg Arg Leu Leu  Pro Gly Pro Gln Glu  Asn Ser Val 
    1100                 1105                 1110             


Gln Ser  Ser Ala Cys Gly Arg  Gln His Leu Glu Pro  Thr Gly Thr 
    1115                 1120                 1125             


Ile Asp  Met Arg Gly Pro Gly  Gln Ala Asp Cys Ala  Val Ala Ile 
    1130                 1135                 1140             


Gly Arg  Pro Leu Gly Glu Val  Val Thr Leu Arg Val  Leu Glu Ser 
    1145                 1150                 1155             


Ser Leu  Asn Cys Ser Ala Gly  Asp Met Leu Leu Leu  Trp Gly Arg 
    1160                 1165                 1170             


Leu Thr  Trp Arg Lys Met Cys  Arg Lys Leu Leu Asp  Met Thr Phe 
    1175                 1180                 1185             


Ser Ser  Lys Thr Asn Thr Leu  Val Val Arg Gln Arg  Cys Gly Arg 
    1190                 1195                 1200             


Pro Gly  Gly Gly Val Leu Leu  Arg Tyr Gly Ser Gln  Leu Ala Pro 
    1205                 1210                 1215             


Glu Thr  Phe Tyr Arg Glu Cys  Asp Met Gln Leu Phe  Gly Pro Trp 
    1220                 1225                 1230             


Gly Glu  Ile Val Ser Pro Ser  Leu Ser Pro Ala Thr  Ser Asn Ala 
    1235                 1240                 1245             


Gly Gly  Cys Arg Leu Phe Ile  Asn Val Ala Pro His  Ala Arg Ile 
    1250                 1255                 1260             


Ala Ile  His Ala Leu Ala Thr  Asn Met Gly Ala Gly  Thr Glu Gly 
    1265                 1270                 1275             


Ala Asn  Ala Ser Tyr Ile Leu  Ile Arg Asp Thr His  Ser Leu Arg 
    1280                 1285                 1290             


Thr Thr  Ala Phe His Gly Gln  Gln Val Leu Tyr Trp  Glu Ser Glu 
    1295                 1300                 1305             


Ser Ser  Gln Ala Glu Met Glu  Phe Ser Glu Gly Phe  Leu Lys Ala 
    1310                 1315                 1320             


Gln Ala  Ser Leu Arg Gly Gln  Tyr Trp Thr Leu Gln  Ser Trp Val 
    1325                 1330                 1335             


Pro Glu  Met Gln Asp Pro Gln  Ser Trp Lys Gly Lys  Glu Gly Thr 
    1340                 1345                 1350             


<210>  72
<211>  1453
<212>  PRT
<213>  Homo sapiens

<400>  72

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  73
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with point mutations 
       R568K/F592Y/R660K/Y661F/Y665F

<400>  73

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Lys Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Tyr 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Lys Phe Gly Glu Glu Phe Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  74
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation A1144V

<400>  74

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Val Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  75
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation A1145V

<400>  75

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Val  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  76
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation A1146V

<400>  76

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Val Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  77
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1147V

<400>  77

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Val Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  78
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1154V

<400>  78

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Val Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  79
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1171V

<400>  79

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Val Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  80
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1173V

<400>  80

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Val 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  81
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1175V

<400>  81

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Val  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  82
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1180V

<400>  82

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Val  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  83
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1182V

<400>  83

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Val Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  84
<211>  4359
<212>  DNA
<213>  Homo sapiens

<400>  84
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  85
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       point mutations R568K/F592Y/R660K/Y661F/Y665F

<400>  85
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gaaggaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctctacacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggaag     1980

tttggcgagg agtttggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  86
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation A1144V

<400>  86
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag tggctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  87
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation A1145V

<400>  87
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgtggctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  88
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation A1146V

<400>  88
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgtgcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  89
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1147V

<400>  89
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctgt gggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  90
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1154V

<400>  90
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccg tggctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  91
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1171V

<400>  91
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc gtggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  92
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1173V

<400>  92
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctgtgc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  93
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1175V

<400>  93
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc aggtgcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  94
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1180V

<400>  94
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctggtg     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  95
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1182V

<400>  95
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

ggggtgcagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  96
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation A1144K

<400>  96

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Lys Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  97
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation A1144I

<400>  97

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ile Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  98
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation A1145K

<400>  98

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Lys  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  99
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation A1145I

<400>  99

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ile  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  100
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation A1146K

<400>  100

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Lys Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  101
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation A1146I

<400>  101

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ile Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  102
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1147K

<400>  102

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Lys Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  103
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1147I

<400>  103

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Ile Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  104
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1154K

<400>  104

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Lys Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  105
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1154I

<400>  105

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Ile Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  106
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1171K

<400>  106

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Lys Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  107
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1171I

<400>  107

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Ile Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  108
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1173K

<400>  108

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Lys 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  109
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1173I

<400>  109

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Ile 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  110
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1175K

<400>  110

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Lys  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  111
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1175I

<400>  111

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Ile  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  112
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1180K

<400>  112

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Lys  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  113
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1180I

<400>  113

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Ile  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  114
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1182K

<400>  114

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Lys Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  115
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS13 protein with a single point mutation P1182I

<400>  115

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Ile Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr Ser 
    1415                 1420                 1425             


Arg Gly  Pro Phe Glu Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn 
    1430                 1435                 1440             


Met His  Thr Gly His His His  His His His 
    1445                 1450             


<210>  116
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation A1144K

<400>  116
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaaa aggctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  117
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation A1144I

<400>  117
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaaa ttgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  118
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation A1145K

<400>  118
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccaaggctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  119
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation A1145I

<400>  119
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccattgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  120
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation A1146K

<400>  120
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctaagcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  121
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation A1146I

<400>  121
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctattcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  122
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1147K

<400>  122
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctaa gggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  123
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1147I

<400>  123
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctat tggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  124
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1154K

<400>  124
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccacca aggctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  125
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1154I

<400>  125
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccacca ttgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  126
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1171K

<400>  126
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc aaggctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  127
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1171I

<400>  127
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc attgctcccc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  128
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1173K

<400>  128
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctaagc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  129
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1173I

<400>  129
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctattc agcctcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  130
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1175K

<400>  130
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agaagcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  131
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1175I

<400>  131
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agattcggcg gctcctgccc     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  132
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1180K

<400>  132
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgaag     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  133
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1180I

<400>  133
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgatt     3540

gggccccagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  134
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1182K

<400>  134
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggaagcagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  135
<211>  4359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence corresponding to Human ADAMTS13 protein with 
       a single point mutation P1182I

<400>  135
atgcaccagc gtcacccccg ggcaagatgc cctcccctct gtgtggccgg aatccttgcc       60

tgtggctttc tcctgggctg ctggggaccc tcccatttcc agcagagctg tcttcaggct      120

ttggagccac aggccgtgtc ttcttacttg agccctggtg ctcccttaaa aggccgccct      180

ccttcccctg gcttccagag gcagaggcag aggcagaggc gggctgcagg cggcatccta      240

cacctggagc tgctggtggc cgtgggcccc gatgtcttcc aggctcacca ggaggacaca      300

gagcgctatg tgctcaccaa cctcaacatc ggggcagaac tgcttcggga cccgtccctg      360

ggggctcagt ttcgggtgca cctggtgaag atggtcattc tgacagagcc tgagggtgct      420

ccaaatatca cagccaacct cacctcgtcc ctgctgagcg tctgtgggtg gagccagacc      480

atcaaccctg aggacgacac ggatcctggc catgctgacc tggtcctcta tatcactagg      540

tttgacctgg agttgcctga tggtaaccgg caggtgcggg gcgtcaccca gctgggcggt      600

gcctgctccc caacctggag ctgcctcatt accgaggaca ctggcttcga cctgggagtc      660

accattgccc atgagattgg gcacagcttc ggcctggagc acgacggcgc gcccggcagc      720

ggctgcggcc ccagcggaca cgtgatggct tcggacggcg ccgcgccccg cgccggcctc      780

gcctggtccc cctgcagccg ccggcagctg ctgagcctgc tcagcgcagg acgggcgcgc      840

tgcgtgtggg acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcc ggatgcgcag      900

cctggcctct actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc      960

gcctgcacct tcgccaggga gcacctggat atgtgccagg ccctctcctg ccacacagac     1020

ccgctggacc aaagcagctg cagccgcctc ctcgttcctc tcctggatgg gacagaatgt     1080

ggcgtggaga agtggtgctc caaaggtcgc tgccgctccc tggtggagct gacccccata     1140

gcagcagtgc atgggcgctg gtctagctgg ggtccccgaa gtccttgctc ccgctcctgc     1200

ggaggaggtg tggtcaccag gaggcggcag tgcaacaacc ccagacctgc ctttgggggg     1260

cgtgcatgtg ttggtgctga cctccaggcc gagatgtgca acactcaggc ctgcgagaag     1320

acccagctgg agttcatgtc gcaacagtgc gccaggaccg acggccagcc gctgcgctcc     1380

tcccctggcg gcgcctcctt ctaccactgg ggtgctgctg taccacacag ccaaggggat     1440

gctctgtgca gacacatgtg ccgggccatt ggcgagagct tcatcatgaa gcgtggagac     1500

agcttcctcg atgggacccg gtgtatgcca agtggccccc gggaggacgg gaccctgagc     1560

ctgtgtgtgt cgggcagctg caggacattt ggctgtgatg gtaggatgga ctcccagcag     1620

gtatgggaca ggtgccaggt gtgtggtggg gacaacagca cgtgcagccc acggaagggc     1680

tctttcacag ctggcagagc gagagaatat gtcacgtttc tgacagttac ccccaacctg     1740

accagtgtct acattgccaa ccacaggcct ctcttcacac acttggcggt gaggatcgga     1800

gggcgctatg tcgtggctgg gaagatgagc atctccccta acaccaccta cccctccctc     1860

ctggaggatg gtcgtgtcga gtacagagtg gccctcaccg aggaccggct gccccgcctg     1920

gaggagatcc gcatctgggg acccctccag gaagatgctg acatccaggt ttacaggcgg     1980

tatggcgagg agtatggcaa cctcacccgc ccagacatca ccttcaccta cttccagcct     2040

aagccacggc aggcctgggt gtgggccgct gtgcgtgggc cctgctcggt gagctgtggg     2100

gcagggctgc gctgggtaaa ctacagctgc ctggaccagg ccaggaagga gttggtggag     2160

actgtccagt gccaagggag ccagcagcca ccagcgtggc cagaggcctg cgtgctcgaa     2220

ccctgccctc cctactgggc ggtgggagac ttcggcccat gcagcgcctc ctgtgggggt     2280

ggcctgcggg agcggccagt gcgctgcgtg gaggcccagg gcagcctcct gaagacattg     2340

cccccagccc ggtgcagagc aggggcccag cagccagctg tggcgctgga aacctgcaac     2400

ccccagccct gccctgccag gtgggaggtg tcagagccca gctcatgcac atcagctggt     2460

ggagcaggcc tggccttgga gaacgagacc tgtgtgccag gggcagatgg cctggaggct     2520

ccagtgactg aggggcctgg ctccgtagat gagaagctgc ctgcccctga gccctgtgtc     2580

gggatgtcat gtcctccagg ctggggccat ctggatgcca cctctgcagg ggagaaggct     2640

ccctccccat ggggcagcat caggacgggg gctcaagctg cacacgtgtg gacccctgcg     2700

gcagggtcgt gctccgtctc ctgcgggcga ggtctgatgg agctccgttt cctgtgcatg     2760

gactctgccc tcagggtgcc tgtccaggaa gagctgtgtg gcctggcaag caagcctggg     2820

agccggcggg aggtctgcca ggctgtcccg tgccctgctc ggtggcagta caagctggcg     2880

gcctgcagcg tgagctgtgg gagaggggtc gtgcggagga tcctgtattg tgcccgggcc     2940

catggggagg acgatggtga ggagatcctg ttggacaccc agtgccaggg gctgcctcgc     3000

ccggaacccc aggaggcctg cagcctggag ccctgcccac ctaggtggaa agtcatgtcc     3060

cttggcccat gttcggccag ctgtggcctt ggcactgcta gacgctcggt ggcctgtgtg     3120

cagctcgacc aaggccagga cgtggaggtg gacgaggcgg cctgtgcggc gctggtgcgg     3180

cccgaggcca gtgtcccctg tctcattgcc gactgcacct accgctggca tgttggcacc     3240

tggatggagt gctctgtttc ctgtggggat ggcatccagc gccggcgtga cacctgcctc     3300

ggaccccagg cccaggcgcc tgtgccagct gatttctgcc agcacttgcc caagccggtg     3360

actgtgcgtg gctgctgggc tgggccctgt gtgggacagg gtacgcccag cctggtgccc     3420

cacgaagaag ccgctgctcc aggacggacc acagccaccc ctgctggtgc ctccctggag     3480

tggtcccagg cccggggcct gctcttctcc ccggctcccc agcctcggcg gctcctgccc     3540

gggattcagg aaaactcagt gcagtccagt gcctgtggca ggcagcacct tgagccaaca     3600

ggaaccattg acatgcgagg cccagggcag gcagactgtg cagtggccat tgggcggccc     3660

ctcggggagg tggtgaccct ccgcgtcctt gagagttctc tcaactgcag tgcgggggac     3720

atgttgctgc tttggggccg gctcacctgg aggaagatgt gcaggaagct gttggacatg     3780

actttcagct ccaagaccaa cacgctggtg gtgaggcagc gctgcgggcg gccaggaggt     3840

ggggtgctgc tgcggtatgg gagccagctt gctcctgaaa ccttctacag agaatgtgac     3900

atgcagctct ttgggccctg gggtgaaatc gtgagcccct cgctgagtcc agccacgagt     3960

aatgcagggg gctgccggct cttcattaat gtggctccgc acgcacggat tgccatccat     4020

gccctggcca ccaacatggg cgctgggacc gagggagcca atgccagcta catcttgatc     4080

cgggacaccc acagcttgag gaccacagcg ttccatgggc agcaggtgct ctactgggag     4140

tcagagagca gccaggctga gatggagttc agcgagggct tcctgaaggc tcaggccagc     4200

ctgcggggcc agtactggac cctccaatca tgggtaccgg agatgcagga ccctcagtcc     4260

tggaagggaa aggaaggaac ctctagaggg cccttcgaac aaaaactcat ctcagaagag     4320

gatctgaata tgcataccgg tcatcatcac catcaccat                            4359


<210>  136
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation A1144K

<400>  136

Lys Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  137
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation A1145K

<400>  137

Ala Lys Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  138
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation A1146K

<400>  138

Ala Ala Lys Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  139
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1147K

<400>  139

Ala Ala Ala Lys Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  140
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1154K

<400>  140

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Lys Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  141
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1171K

<400>  141

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Lys Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  142
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1173K

<400>  142

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Lys Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  143
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1175K

<400>  143

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Lys 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  144
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1180K

<400>  144

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Lys Gly Pro 
        35                  


<210>  145
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1182K

<400>  145

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Lys 
        35                  


<210>  146
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation A1144I

<400>  146

Ile Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  147
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation A1145I

<400>  147

Ala Ile Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  148
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation A1146I

<400>  148

Ala Ala Ile Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  149
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1147I

<400>  149

Ala Ala Ala Ile Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  150
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1154I

<400>  150

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Ile Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  151
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1171I

<400>  151

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Ile Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  152
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1173I

<400>  152

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Ile Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  153
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1175I

<400>  153

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Ile 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Pro 
        35                  


<210>  154
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1180I

<400>  154

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Ile Gly Pro 
        35                  


<210>  155
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein with a single point 
       mutation P1182I

<400>  155

Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro 
            20                  25                  30          


Arg Arg Leu Leu Pro Gly Ile 
        35                  


<210>  156
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3 subregion of Human ADAMTS13 protein concensus sequence

<400>  156

Xaa Xaa Xaa Xaa Gly Arg Thr Thr Ala Thr Xaa Ala Gly Ala Ser Leu 
1               5                   10                  15      


Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Xaa Ala Xaa Gln Xaa 
            20                  25                  30          


Arg Arg Leu Leu Xaa Gly Xaa 
        35                  


