                         SEQUENCE LISTING

<110>  Oxford University Innovation Limited
 
<120>  MODIFIED HUMAN CELLS AND USES THEREOF IN THE TREATMENT OF 
       IMMUNE-MEDIATED DISEASES

<130>  489.141146/02

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  1187
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Leu Arg His Trp Gly Met Ala Arg Gly Ser Lys Pro Val Gly 
1               5                   10                  15      


Asp Gly Ala Gln Pro Met Ala Ala Met Gly Gly Leu Lys Val Leu Leu 
            20                  25                  30          


His Trp Ala Gly Pro Gly Gly Gly Glu Pro Trp Val Thr Phe Ser Glu 
        35                  40                  45              


Ser Ser Leu Thr Ala Glu Glu Val Cys Ile His Ile Ala His Lys Val 
    50                  55                  60                  


Gly Ile Thr Pro Pro Cys Phe Asn Leu Phe Ala Leu Phe Asp Ala Gln 
65                  70                  75                  80  


Ala Gln Val Trp Leu Pro Pro Asn His Ile Leu Glu Ile Pro Arg Asp 
                85                  90                  95      


Ala Ser Leu Met Leu Tyr Phe Arg Ile Arg Phe Tyr Phe Arg Asn Trp 
            100                 105                 110         


His Gly Met Asn Pro Arg Glu Pro Ala Val Tyr Arg Cys Gly Pro Pro 
        115                 120                 125             


Gly Thr Glu Ala Ser Ser Asp Gln Thr Ala Gln Gly Met Gln Leu Leu 
    130                 135                 140                 


Asp Pro Ala Ser Phe Glu Tyr Leu Phe Glu Gln Gly Lys His Glu Phe 
145                 150                 155                 160 


Val Asn Asp Val Ala Ser Leu Trp Glu Leu Ser Thr Glu Glu Glu Ile 
                165                 170                 175     


His His Phe Lys Asn Glu Ser Leu Gly Met Ala Phe Leu His Leu Cys 
            180                 185                 190         


His Leu Ala Leu Arg His Gly Ile Pro Leu Glu Glu Val Ala Lys Lys 
        195                 200                 205             


Thr Ser Phe Lys Asp Cys Ile Pro Arg Ser Phe Arg Arg His Ile Arg 
    210                 215                 220                 


Gln His Ser Ala Leu Thr Arg Leu Arg Leu Arg Asn Val Phe Arg Arg 
225                 230                 235                 240 


Phe Leu Arg Asp Phe Gln Pro Gly Arg Leu Ser Gln Gln Met Val Met 
                245                 250                 255     


Val Lys Tyr Leu Ala Thr Leu Glu Arg Leu Ala Pro Arg Phe Gly Thr 
            260                 265                 270         


Glu Arg Val Pro Val Cys His Leu Arg Leu Leu Ala Gln Ala Glu Gly 
        275                 280                 285             


Glu Pro Cys Tyr Ile Arg Asp Ser Gly Val Ala Pro Thr Asp Pro Gly 
    290                 295                 300                 


Pro Glu Ser Ala Ala Gly Pro Pro Thr His Glu Val Leu Val Thr Gly 
305                 310                 315                 320 


Thr Gly Gly Ile Gln Trp Trp Pro Val Glu Glu Glu Val Asn Lys Glu 
                325                 330                 335     


Glu Gly Ser Ser Gly Ser Ser Gly Arg Asn Pro Gln Ala Ser Leu Phe 
            340                 345                 350         


Gly Lys Lys Ala Lys Ala His Lys Ala Val Gly Gln Pro Ala Asp Arg 
        355                 360                 365             


Pro Arg Glu Pro Leu Trp Ala Tyr Phe Cys Asp Phe Arg Asp Ile Thr 
    370                 375                 380                 


His Val Val Leu Lys Glu His Cys Val Ser Ile His Arg Gln Asp Asn 
385                 390                 395                 400 


Lys Cys Leu Glu Leu Ser Leu Pro Ser Arg Ala Ala Ala Leu Ser Phe 
                405                 410                 415     


Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr Ala Asp Ser Ser His 
            420                 425                 430         


Tyr Leu Cys His Glu Val Ala Pro Pro Arg Leu Val Met Ser Ile Arg 
        435                 440                 445             


Asp Gly Ile His Gly Pro Leu Leu Glu Pro Phe Val Gln Ala Lys Leu 
    450                 455                 460                 


Arg Pro Glu Asp Gly Leu Tyr Leu Ile His Trp Ser Thr Ser His Pro 
465                 470                 475                 480 


Tyr Arg Leu Ile Leu Thr Val Ala Gln Arg Ser Gln Ala Pro Asp Gly 
                485                 490                 495     


Met Gln Ser Leu Arg Leu Arg Lys Phe Pro Ile Glu Gln Gln Asp Gly 
            500                 505                 510         


Ala Phe Val Leu Glu Gly Trp Gly Arg Ser Phe Pro Ser Val Arg Glu 
        515                 520                 525             


Leu Gly Ala Ala Leu Gln Gly Cys Leu Leu Arg Ala Gly Asp Asp Cys 
    530                 535                 540                 


Phe Ser Leu Arg Arg Cys Cys Leu Pro Gln Pro Gly Glu Thr Ser Asn 
545                 550                 555                 560 


Leu Ile Ile Met Arg Gly Ala Arg Ala Ser Pro Arg Thr Leu Asn Leu 
                565                 570                 575     


Ser Gln Leu Ser Phe His Arg Val Asp Gln Lys Glu Ile Thr Gln Leu 
            580                 585                 590         


Ser His Leu Gly Gln Gly Thr Arg Thr Asn Val Tyr Glu Gly Arg Leu 
        595                 600                 605             


Arg Val Glu Gly Ser Gly Asp Pro Glu Glu Gly Lys Met Asp Asp Glu 
    610                 615                 620                 


Asp Pro Leu Val Pro Gly Arg Asp Arg Gly Gln Glu Leu Arg Val Val 
625                 630                 635                 640 


Leu Lys Val Leu Asp Pro Ser His His Asp Ile Ala Leu Ala Phe Tyr 
                645                 650                 655     


Glu Thr Ala Ser Leu Met Ser Gln Val Ser His Thr His Leu Ala Phe 
            660                 665                 670         


Val His Gly Val Cys Val Arg Gly Pro Glu Asn Ile Met Val Thr Glu 
        675                 680                 685             


Tyr Val Glu His Gly Pro Leu Asp Val Trp Leu Arg Arg Glu Arg Gly 
    690                 695                 700                 


His Val Pro Met Ala Trp Lys Met Val Val Ala Gln Gln Leu Ala Ser 
705                 710                 715                 720 


Ala Leu Ser Tyr Leu Glu Asn Lys Asn Leu Val His Gly Asn Val Cys 
                725                 730                 735     


Gly Arg Asn Ile Leu Leu Ala Arg Leu Gly Leu Ala Glu Gly Thr Ser 
            740                 745                 750         


Pro Phe Ile Lys Leu Ser Asp Pro Gly Val Gly Leu Gly Ala Leu Ser 
        755                 760                 765             


Arg Glu Glu Arg Val Glu Arg Ile Pro Trp Leu Ala Pro Glu Cys Leu 
    770                 775                 780                 


Pro Gly Gly Ala Asn Ser Leu Ser Thr Ala Met Asp Lys Trp Gly Phe 
785                 790                 795                 800 


Gly Ala Thr Leu Leu Glu Ile Cys Phe Asp Gly Glu Ala Pro Leu Gln 
                805                 810                 815     


Ser Arg Ser Pro Ser Glu Lys Glu His Phe Tyr Gln Arg Gln His Arg 
            820                 825                 830         


Leu Pro Glu Pro Ser Cys Pro Gln Leu Ala Thr Leu Thr Ser Gln Cys 
        835                 840                 845             


Leu Thr Tyr Glu Pro Thr Gln Arg Pro Ser Phe Arg Thr Ile Leu Arg 
    850                 855                 860                 


Asp Leu Thr Arg Leu Gln Pro His Asn Leu Ala Asp Val Leu Thr Val 
865                 870                 875                 880 


Asn Pro Asp Ser Pro Ala Ser Asp Pro Thr Val Phe His Lys Arg Tyr 
                885                 890                 895     


Leu Lys Lys Ile Arg Asp Leu Gly Glu Gly His Phe Gly Lys Val Ser 
            900                 905                 910         


Leu Tyr Cys Tyr Asp Pro Thr Asn Asp Gly Thr Gly Glu Met Val Ala 
        915                 920                 925             


Val Lys Ala Leu Lys Ala Asp Cys Gly Pro Gln His Arg Ser Gly Trp 
    930                 935                 940                 


Lys Gln Glu Ile Asp Ile Leu Arg Thr Leu Tyr His Glu His Ile Ile 
945                 950                 955                 960 


Lys Tyr Lys Gly Cys Cys Glu Asp Gln Gly Glu Lys Ser Leu Gln Leu 
                965                 970                 975     


Val Met Glu Tyr Val Pro Leu Gly Ser Leu Arg Asp Tyr Leu Pro Arg 
            980                 985                 990         


His Ser Ile Gly Leu Ala Gln Leu  Leu Leu Phe Ala Gln  Gln Ile Cys 
        995                 1000                 1005             


Glu Gly  Met Ala Tyr Leu His  Ala Gln His Tyr Ile  His Arg Asp 
    1010                 1015                 1020             


Leu Ala  Ala Arg Asn Val Leu  Leu Asp Asn Asp Arg  Leu Val Lys 
    1025                 1030                 1035             


Ile Gly  Asp Phe Gly Leu Ala  Lys Ala Val Pro Glu  Gly His Glu 
    1040                 1045                 1050             


Tyr Tyr  Arg Val Arg Glu Asp  Gly Asp Ser Pro Val  Phe Trp Tyr 
    1055                 1060                 1065             


Ala Pro  Glu Cys Leu Lys Glu  Tyr Lys Phe Tyr Tyr  Ala Ser Asp 
    1070                 1075                 1080             


Val Trp  Ser Phe Gly Val Thr  Leu Tyr Glu Leu Leu  Thr His Cys 
    1085                 1090                 1095             


Asp Ser  Ser Gln Ser Pro Pro  Thr Lys Phe Leu Glu  Leu Ile Gly 
    1100                 1105                 1110             


Ile Ala  Gln Gly Gln Met Thr  Val Leu Arg Leu Thr  Glu Leu Leu 
    1115                 1120                 1125             


Glu Arg  Gly Glu Arg Leu Pro  Arg Pro Asp Lys Cys  Pro Cys Glu 
    1130                 1135                 1140             


Val Tyr  His Leu Met Lys Asn  Cys Trp Glu Thr Glu  Ala Ser Phe 
    1145                 1150                 1155             


Arg Pro  Thr Phe Glu Asn Leu  Ile Pro Ile Leu Lys  Thr Val His 
    1160                 1165                 1170             


Glu Lys  Tyr Gln Gly Gln Ala  Pro Ser Val Phe Ser  Val Cys 
    1175                 1180                 1185         


<210>  2
<211>  4243
<212>  DNA
<213>  Homo sapiens

<400>  2
aagcagtagc tacccgcggg agcggggagg ggtccgggtt cgagcttgtg ttcccccgga       60

agggtgagtc tggacgcggg cgcggaagga gcgcggccgg aggtcctcag gaagaagccg      120

cggggactgg ctgcgcttga caggctgcac ttggatggga gcacctggtg cctcgggact      180

gctccgatgc ccgggtctgt gctgaatgtg taatatgcgg aactatattg aaacattaca      240

accatctttt gatggcaaca ccctgaggac ctcccttttc cagatgggga aactgaggcc      300

cagaattgct aagtggcttg cttgagttga cacagggagc tccaggactc accctcagct      360

gagccacctg ccgggagcat gcctctgcgc cactggggga tggccagggg cagtaagccc      420

gttggggatg gagcccagcc catggctgcc atgggaggcc tgaaggtgct tctgcactgg      480

gctggtccag gcggcgggga gccctgggtc actttcagtg agtcatcgct gacagctgag      540

gaagtctgca tccacattgc acataaagtt ggtatcactc ctccttgctt caatctcttt      600

gccctcttcg atgctcaggc ccaagtctgg ttgcccccaa accacatcct agagatcccc      660

agagatgcaa gcctgatgct atatttccgc ataaggtttt atttccggaa ctggcatggc      720

atgaatcctc gggaaccggc tgtgtaccgt tgtgggcccc caggaaccga ggcatcctca      780

gatcagacag cacaggggat gcaactcctg gacccagcct catttgagta cctctttgag      840

cagggcaagc atgagtttgt gaatgacgtg gcatcactgt gggagctgtc gaccgaggag      900

gagatccacc actttaagaa tgagagcctg ggcatggcct ttctgcacct ctgtcacctc      960

gctctccgcc atggcatccc cctggaggag gtggccaaga agaccagctt caaggactgc     1020

atcccgcgct ccttccgccg gcatatccgg cagcacagcg ccctgacccg gctgcgcctt     1080

cggaacgtct tccgcaggtt cctgcgggac ttccagccgg gccgactctc ccagcagatg     1140

gtcatggtca aatacctagc cacactcgag cggctggcac cccgcttcgg cacagagcgt     1200

gtgcccgtgt gccacctgag gctgctggcc caggccgagg gggagccctg ctacatccgg     1260

gacagtgggg tggcccctac agaccctggc cctgagtctg ctgctgggcc cccaacccac     1320

gaggtgctgg tgacaggcac tggtggcatc cagtggtggc cagtagagga ggaggtgaac     1380

aaggaggagg gttctagtgg cagcagtggc aggaaccccc aagccagcct gtttgggaag     1440

aaggccaagg ctcacaaggc agtcggccag ccggcagaca ggccgcggga gccactgtgg     1500

gcctacttct gtgacttccg ggacatcacc cacgtggtgc tgaaagagca ctgtgtcagc     1560

atccaccggc aggacaacaa gtgcctggag ctgagcttgc cttcccgggc tgcggcgctg     1620

tccttcgtgt cgctggtgga cggctatttc cgcctgacgg ccgactccag ccactacctg     1680

tgccacgagg tggctccccc acggctggtg atgagcatcc gggatgggat ccacggaccc     1740

ctgctggagc catttgtgca ggccaagctg cggcccgagg acggcctgta cctcattcac     1800

tggagcacca gccaccccta ccgcctgatc ctcacagtgg cccagcgtag ccaggcacca     1860

gacggcatgc agagcttgcg gctccgaaag ttccccattg agcagcagga cggggccttc     1920

gtgctggagg gctggggccg gtccttcccc agcgttcggg aacttggggc tgccttgcag     1980

ggctgcttgc tgagggccgg ggatgactgc ttctctctgc gtcgctgttg cctgccccaa     2040

ccaggagaaa cctccaatct catcatcatg cggggggctc gggccagccc caggacactc     2100

aacctcagcc agctcagctt ccaccgggtt gaccagaagg agatcaccca gctgtcccac     2160

ttgggccagg gcacaaggac caacgtgtat gagggccgcc tgcgagtgga gggcagcggg     2220

gaccctgagg agggcaagat ggatgacgag gaccccctcg tgcctggcag ggaccgtggg     2280

caggagctac gagtggtgct caaagtgctg gaccctagtc accatgacat cgccctggcc     2340

ttctacgaga cagccagcct catgagccag gtctcccaca cgcacctggc cttcgtgcat     2400

ggcgtctgtg tgcgcggccc tgaaaatatc atggtgacag agtacgtgga gcacggaccc     2460

ctggatgtgt ggctgcggag ggagcggggc catgtgccca tggcttggaa gatggtggtg     2520

gcccagcagc tggccagcgc cctcagctac ctggagaaca agaacctggt tcatggtaat     2580

gtgtgtggcc ggaacatcct gctggcccgg ctggggttgg cagagggcac cagccccttc     2640

atcaagctga gtgatcctgg cgtgggcctg ggcgccctct ccagggagga gcgggtggag     2700

aggatcccct ggctggcccc cgaatgccta ccaggtgggg ccaacagcct aagcaccgcc     2760

atggacaagt gggggtttgg cgccaccctc ctggagatct gctttgacgg agaggcccct     2820

ctgcagagcc gcagtccctc cgagaaggag catttctacc agaggcagca ccggctgccc     2880

gagccctcct gcccacagct ggccacactc accagccagt gtctgaccta tgagccaacc     2940

cagaggccat cattccgcac catcctgcgt gacctcaccc ggctgcagcc ccacaatctt     3000

gctgacgtct tgactgtgaa cccggactca ccggcgtcgg accctacggt tttccacaag     3060

cgctatttga aaaagatccg agatctgggc gagggtcact tcggcaaggt cagcttgtac     3120

tgctacgatc cgaccaacga cggcactggc gagatggtgg cggtgaaagc cctcaaggca     3180

gactgcggcc cccagcaccg ctcgggctgg aagcaggaga ttgacattct gcgcacgctc     3240

taccacgagc acatcatcaa gtacaagggc tgctgcgagg accaaggcga gaagtcgctg     3300

cagctggtca tggagtacgt gcccctgggc agcctccgag actacctgcc ccggcacagc     3360

atcgggctgg cccagctgct gctcttcgcc cagcagatct gcgagggcat ggcctatctg     3420

cacgcgcagc actacatcca ccgagaccta gccgcgcgca acgtgctgct ggacaacgac     3480

aggctggtca agatcgggga ctttggccta gccaaggccg tgcccgaagg ccacgagtac     3540

taccgcgtgc gcgaggatgg ggacagcccc gtgttctggt atgccccaga gtgcctgaag     3600

gagtataagt tctactatgc gtcagatgtc tggtccttcg gggtgaccct gtatgagctg     3660

ctgacgcact gtgactccag ccagagcccc cccacgaaat tccttgagct cataggcatt     3720

gctcagggtc agatgacagt tctgagactc actgagttgc tggaacgagg ggagaggctg     3780

ccacggcccg acaaatgtcc ctgtgaggtc tatcatctca tgaagaactg ctgggagaca     3840

gaggcgtcct ttcgcccaac cttcgagaac ctcataccca ttctgaagac agtccatgag     3900

aagtaccaag gccaggcccc ttcagtgttc agcgtgtgct gaggcacaat ggcagccctg     3960

cctgggagga ctggaccagg cagtggctgc agagggagcc tcctgctccc tgctccagga     4020

tgaaaccaag agggggatgt cagcctcacc cacaccgtgt gccttactcc tgtctagaga     4080

ccccacctct gtgaacttat ttttctttct tggccgtgag cctaaccatg atcttgaggg     4140

acccaacatt tgtaggggca ctaatccagc ccttaaatcc cccagcttcc aaacttgagg     4200

cccaccatct ccaccatctg gtaataaact catgttttct ctg                       4243


<210>  3
<211>  3971
<212>  DNA
<213>  Homo sapiens

<400>  3
agctggggtg ggtggaaggt tgaagagcta acaggggtct ctgggctgag acttgggagc       60

tgacagattg tcccctttcc agctgagcca cctgccggga gcatgcctct gcgccactgg      120

gggatggcca ggggcagtaa gcccgttggg gatggagccc agcccatggc tgccatggga      180

ggcctgaagg tgcttctgca ctgggctggt ccaggcggcg gggagccctg ggtcactttc      240

agtgagtcat cgctgacagc tgaggaagtc tgcatccaca ttgcacataa agttggtatc      300

actcctcctt gcttcaatct ctttgccctc ttcgatgctc aggcccaagt ctggttgccc      360

ccaaaccaca tcctagagat ccccagagat gcaagcctga tgctatattt ccgcataagg      420

ttttatttcc ggaactggca tggcatgaat cctcgggaac cggctgtgta ccgttgtggg      480

cccccaggaa ccgaggcatc ctcagatcag acagcacagg ggatgcaact cctggaccca      540

gcctcatttg agtacctctt tgagcagggc aagcatgagt ttgtgaatga cgtggcatca      600

ctgtgggagc tgtcgaccga ggaggagatc caccacttta agaatgagag cctgggcatg      660

gcctttctgc acctctgtca cctcgctctc cgccatggca tccccctgga ggaggtggcc      720

aagaagacca gcttcaagga ctgcatcccg cgctccttcc gccggcatat ccggcagcac      780

agcgccctga cccggctgcg ccttcggaac gtcttccgca ggttcctgcg ggacttccag      840

ccgggccgac tctcccagca gatggtcatg gtcaaatacc tagccacact cgagcggctg      900

gcaccccgct tcggcacaga gcgtgtgccc gtgtgccacc tgaggctgct ggcccaggcc      960

gagggggagc cctgctacat ccgggacagt ggggtggccc ctacagaccc tggccctgag     1020

tctgctgctg ggcccccaac ccacgaggtg ctggtgacag gcactggtgg catccagtgg     1080

tggccagtag aggaggaggt gaacaaggag gagggttcta gtggcagcag tggcaggaac     1140

ccccaagcca gcctgtttgg gaagaaggcc aaggctcaca aggcagtcgg ccagccggca     1200

gacaggccgc gggagccact gtgggcctac ttctgtgact tccgggacat cacccacgtg     1260

gtgctgaaag agcactgtgt cagcatccac cggcaggaca acaagtgcct ggagctgagc     1320

ttgccttccc gggctgcggc gctgtccttc gtgtcgctgg tggacggcta tttccgcctg     1380

acggccgact ccagccacta cctgtgccac gaggtggctc ccccacggct ggtgatgagc     1440

atccgggatg ggatccacgg acccctgctg gagccatttg tgcaggccaa gctgcggccc     1500

gaggacggcc tgtacctcat tcactggagc accagccacc cctaccgcct gatcctcaca     1560

gtggcccagc gtagccaggc accagacggc atgcagagct tgcggctccg aaagttcccc     1620

attgagcagc aggacggggc cttcgtgctg gagggctggg gccggtcctt ccccagcgtt     1680

cgggaacttg gggctgcctt gcagggctgc ttgctgaggg ccggggatga ctgcttctct     1740

ctgcgtcgct gttgcctgcc ccaaccagga gaaacctcca atctcatcat catgcggggg     1800

gctcgggcca gccccaggac actcaacctc agccagctca gcttccaccg ggttgaccag     1860

aaggagatca cccagctgtc ccacttgggc cagggcacaa ggaccaacgt gtatgagggc     1920

cgcctgcgag tggagggcag cggggaccct gaggagggca agatggatga cgaggacccc     1980

ctcgtgcctg gcagggaccg tgggcaggag ctacgagtgg tgctcaaagt gctggaccct     2040

agtcaccatg acatcgccct ggccttctac gagacagcca gcctcatgag ccaggtctcc     2100

cacacgcacc tggccttcgt gcatggcgtc tgtgtgcgcg gccctgaaaa tatcatggtg     2160

acagagtacg tggagcacgg acccctggat gtgtggctgc ggagggagcg gggccatgtg     2220

cccatggctt ggaagatggt ggtggcccag cagctggcca gcgccctcag ctacctggag     2280

aacaagaacc tggttcatgg taatgtgtgt ggccggaaca tcctgctggc ccggctgggg     2340

ttggcagagg gcaccagccc cttcatcaag ctgagtgatc ctggcgtggg cctgggcgcc     2400

ctctccaggg aggagcgggt ggagaggatc ccctggctgg cccccgaatg cctaccaggt     2460

ggggccaaca gcctaagcac cgccatggac aagtgggggt ttggcgccac cctcctggag     2520

atctgctttg acggagaggc ccctctgcag agccgcagtc cctccgagaa ggagcatttc     2580

taccagaggc agcaccggct gcccgagccc tcctgcccac agctggccac actcaccagc     2640

cagtgtctga cctatgagcc aacccagagg ccatcattcc gcaccatcct gcgtgacctc     2700

acccggctgc agccccacaa tcttgctgac gtcttgactg tgaacccgga ctcaccggcg     2760

tcggacccta cggttttcca caagcgctat ttgaaaaaga tccgagatct gggcgagggt     2820

cacttcggca aggtcagctt gtactgctac gatccgacca acgacggcac tggcgagatg     2880

gtggcggtga aagccctcaa ggcagactgc ggcccccagc accgctcggg ctggaagcag     2940

gagattgaca ttctgcgcac gctctaccac gagcacatca tcaagtacaa gggctgctgc     3000

gaggaccaag gcgagaagtc gctgcagctg gtcatggagt acgtgcccct gggcagcctc     3060

cgagactacc tgccccggca cagcatcggg ctggcccagc tgctgctctt cgcccagcag     3120

atctgcgagg gcatggccta tctgcacgcg cagcactaca tccaccgaga cctagccgcg     3180

cgcaacgtgc tgctggacaa cgacaggctg gtcaagatcg gggactttgg cctagccaag     3240

gccgtgcccg aaggccacga gtactaccgc gtgcgcgagg atggggacag ccccgtgttc     3300

tggtatgccc cagagtgcct gaaggagtat aagttctact atgcgtcaga tgtctggtcc     3360

ttcggggtga ccctgtatga gctgctgacg cactgtgact ccagccagag cccccccacg     3420

aaattccttg agctcatagg cattgctcag ggtcagatga cagttctgag actcactgag     3480

ttgctggaac gaggggagag gctgccacgg cccgacaaat gtccctgtga ggtctatcat     3540

ctcatgaaga actgctggga gacagaggcg tcctttcgcc caaccttcga gaacctcata     3600

cccattctga agacagtcca tgagaagtac caaggccagg ccccttcagt gttcagcgtg     3660

tgctgaggca caatggcagc cctgcctggg aggactggac caggcagtgg ctgcagaggg     3720

agcctcctgc tccctgctcc aggatgaaac caagaggggg atgtcagcct cacccacacc     3780

gtgtgcctta ctcctgtcta gagaccccac ctctgtgaac ttatttttct ttcttggccg     3840

tgagcctaac catgatcttg agggacccaa catttgtagg ggcactaatc cagcccttaa     3900

atcccccagc ttccaaactt gaggcccacc atctccacca tctggtaata aactcatgtt     3960

ttctctgctg g                                                          3971


<210>  4
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  4
ggtggcggtg aaagccctca agg                                               23


<210>  5
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  5
ggtagtctcg gaggctgccc agg                                               23


<210>  6
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  6
ggcgagatgg tggcggtgaa agccctcaag gcagact                                37


<210>  7
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  7
agtctgcctt gagggctttc accgccacca tctcgcc                                37


<210>  8
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Glu Met Val Ala Val Lys Ala Leu Lys Ala Asp 
1               5                   10          


<210>  9
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A928V sequence (Fig 4A)

<400>  9
gctggcgatg tggtggtgag ccctcaggca gact                                   34


<210>  10
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Negative control (Fig4A)

<400>  10
ggtgcgaggt ggcggtgagc cctcaggcag act                                    33


<210>  11
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  11
gtggcggtga aagccctcaa ggcagact                                          28


<210>  12
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  12
agtctgcctt gagggctttc accgccac                                          28


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

Val Ala Val Lys Ala Leu Lys Ala Asp 
1               5                   


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fig 4B

<400>  14
gtggcggtga gccctcaggc agact                                             25


<210>  15
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  15
ggtggccgtg aaggccctga aggaagggtg cggt                                   34


<210>  16
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  16
accgcaccct tccttcaggg ccttcacggc cacc                                   34


<210>  17
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  17

Val Ala Val Lys Ala Leu Lys Glu Gly Cys Gly 
1               5                   10      


<210>  18
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  18
tgggcagcct ccgagactac ctgccccggc acagc                                  35


<210>  19
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  19
gctgtgccgg ggcaggtagt ctcggaggct gccca                                  35


<210>  20
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  20

Leu Gly Ser Leu Arg Asp Tyr Leu Pro Arg His Ser 
1               5                   10          


<210>  21
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R987Q-D988N

<400>  21
tgggcagcct ccaaaactac ctgccccggc acagc                                  35


<210>  22
<211>  35
<212>  DNA
<213>  homo sapiens

<400>  22
tgggcagcct ccgagactac ctgccccggc acagc                                  35


<210>  23
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  23
tgggcagcct ccgagactac ctgccccgg                                         29


<210>  24
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  24
ccggggcagg tagtctcgga ggctgccca                                         29


<210>  25
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  25

Leu Gly Ser Leu Arg Asp Tyr Leu Pro Arg 
1               5                   10  


<210>  26
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fig 5B

<400>  26
tgggcagcct ccaaaactac ctgcccc                                           27


<210>  27
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fig 5B

<400>  27
tgggcagcct ccgagactac ctgcccc                                           27


<210>  28
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  28
tctcaccgtg ggggcgctct ggctggag                                          28


<210>  29
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Negative control - Fig 6

<400>  29
tctcaccgtg ggggggctct ggctg                                             25


