                               SEQUENCE LISTING

<110> CHILDREN'S HEALTH CARE D/B/A CHILDREN'S MINNESOTA

<120> METHODS FOR TREATING B-ALL BY ADMINISTERING A PRE-BCR COMPLEX 
      ANTAGONIST

<130> 00562.0049WOU1

<140>
<141>

<150> 63/278,030
<151> 2021-11-10

<150> 63/149,728
<151> 2021-02-16

<160> 18    

<170> PatentIn version 3.5

<210> 1
<211> 469
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Phe Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Gly Ile Ser Ser Asn Gly Arg Tyr Ile Asn Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Val Val Asp Phe Asp Gln Asp Tyr Asn Gly Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210> 2
<211> 1439
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
gaattcccgc cgccaccatg ggctggtcct gtatcatcct gttcctggtc gccacagcca       60

ccggagtgca cagcgaggtg cagctggtgg aaagcggagg cggcctggtt aagcccggcg      120

gatctctgag actgtcttgt gctgccagcg gcttcacctt cagcaacttc gagatgaact      180

gggtgcggca ggcccctggc aagggactgg aatgggtcag cggcatcagc tctaatggca      240

gatacatcaa ctacgccgac agcgtgaaag gccgcttcac aatctccaga gataacgcca      300

agaacagcct ctacctgcaa atgaatagcc tgcgggccga ggacaccgcc gtgtactact      360

gcgccagagt ggtggacttg accaggacta caacggcttt gattattggg gccagggcac      420

actggtgacc gtgtccagcg ccagcaccaa gggcccctct gtctttcctc tggccccttc      480

tagcaaatct acaagcggag gcaccgccgc cctgggttgt ctggtgaaag actacttccc      540

agagcctgtg accgtgtctt ggaacagcgg cgccctgacc agcggcgtgc acacattccc      600

cgctgtgctg cagagcagcg gcctgtacag cctgagcagc gtggtcaccg tccccagcag      660

ctctctggga acacagacct acatctgcaa cgtgaaccac aagccttcta ataccaaggt      720

ggataagaag gtggaaccta agagttgcga caagacccac acctgtcctc cgtgccccgc      780

ccctgagctg ctgggcggcc ctagcgtgtt tctgttccct ccaaagccca aggacaccct      840

gatgatcagc agaacccctg aggtgacctg cgtggtggtt gatgtgtccc acgaagatcc      900

tgaggtgaag ttcaactggt acgtggacgg cgttgaggtg cataatgcca agacaaagcc      960

aagagaggaa cagtacaaca gcacatacag agtggtgtcc gtgctgaccg tgctgcacca     1020

ggactggctg aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgctcc     1080

tatcgagaag accatcagca aggctaaagg acagcctcgg gaaccccagg tctacaccct     1140

gccccccagc cgggacgagc tgacaaagaa ccaggtgtcc ctgacatgcc tggtgaaggg     1200

cttctacccc tccgacatcg ccgtggaatg ggagagcaat ggccaacctg aaaacaacta     1260

caaaacgacc cctcctgttc tggacagcga cggcagcttc ttcctttata gcaagctgac     1320

agtggacaag agcagatggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc     1380

cctccacaac cactacaccc agaagtccct gagcctgtct cctggcaagt gataagctt      1439


<210> 3
<211> 233
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              


Ser Thr Asp Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn 
            100                 105                 110         


Trp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210> 4
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
gaattcccgc cgccaccatg ggctggtcct gcatcatcct gttcctggtg gccacagcca       60

ccggcgtgca cagcgatatc cagctgaccc agagccccag ctttctgagc gccagcgtgg      120

gcgaccgggt caccatcacc tgtagagcct ctcagggcat ctccaccgac ctcaactggt      180

atcagcagaa acctggcaag gcccctaagc tgctgatcta cgccgcttct aatctggaaa      240

gcggcgtgcc atctagattc agcggctccg gcagcggcac cgagttcacc ctgacaatta      300

gcagcctgca gcctgaggac ttcgccacat actactgcca gcaaagctac aactggccct      360

acaccttcgg cggaggaaca aaggtggaaa tcaagagaac cgtggccgcc cctagcgtgt      420

tcatcttccc ccccagcgac gagcagctga agagcggtac agcttctgtg gtgtgcctgc      480

tgaacaactt ctacccgcgg gaagccaagg tgcagtggaa ggtggacaac gccctgcaga      540

gcggcaacag ccaggagagc gtgacagagc aggacagcaa ggacagcacc tacagcctga      600

gcagcaccct gaccctgagc aaggccgact acgagaagca caaggtgtac gcctgtgaag      660

tgacccacca gggcctgtct agccctgtga ccaagtcttt taacagaggc gagtgctgat      720

aagctt                                                                 726


<210> 5
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Ser Asn Gly Arg Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Asp Phe Asp Gln Asp Tyr Asn Gly Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val 
        115                 120 


<210> 6
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Thr Asp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 7
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Asn Phe Glu Met Asn 
1               5   


<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Gly Ile Ser Ser Asn Gly Arg Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 9
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Ala Arg Val Val Asp Phe Asp Gln Asp Tyr Asn Gly Phe Asp Tyr 
1               5                   10                  15  


<210> 10
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Arg Ala Ser Gln Gly Ile Ser Thr Asp Leu Asn 
1               5                   10      


<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Gln Gln Ser Tyr Asn Trp Pro Tyr Thr 
1               5                   


<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gly Phe Thr Phe Ser Asn Phe Glu 
1               5               


<210> 14
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Ile Ser Ser Asn Gly Arg Tyr Ile 
1               5               


<210> 15
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Ala Arg Val Val Asp Phe Asp Gln Asp Tyr Asn Gly Phe Asp Tyr 
1               5                   10                  15  


<210> 16
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gln Gly Ile Ser Thr Asp 
1               5       


<210> 17
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Ala Ala Ser 
1           


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Gln Gln Ser Tyr Asn Trp Pro Tyr Thr 
1               5                   


