                         SEQUENCE LISTING

<110>  Theripion, Inc.
       Ledbetter, Jeffrey A.
       Hayden-Ledbetter, Martha S.
 
<120>  DNase Fusion Polypeptides and Related Compositions and Methods

<130>  TRP-0510PC

<150>  US 63/151,272
<151>  2021-02-19

<150>  US 63/151,236
<151>  2021-02-19

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  849
<212>  DNA
<213>  Homo sapiens

<400>  1
atgaggggca tgaagctgct gggggcgctg ctggcactgg cggccctact gcagggggcc       60

gtgtccctga agatcgcagc cttcaacatc cagacatttg gggagaccaa gatgtccaat      120

gccaccctcg tcagctacat tgtgcagatc ctgagccgct atgacatcgc cctggtccag      180

gaggtcagag acagccacct gactgccgtg gggaagctgc tggacaacct caatcaggat      240

gcaccagaca cctatcacta cgtggtcagt gagccactgg gacggaacag ctataaggag      300

cgctacctgt tcgtgtacag gcctgaccag gtgtctgcgg tggacagcta ctactacgat      360

gatggctgcg agccctgcgg gaacgacacc ttcaaccgag agccagccat tgtcaggttc      420

ttctcccggt tcacagaggt cagggagttt gccattgttc ccctgcatgc ggccccgggg      480

gacgcagtag ccgagatcga cgctctctat gacgtctacc tggatgtcca agagaaatgg      540

ggcttggagg acgtcatgtt gatgggcgac ttcaatgcgg gctgcagcta tgtgagaccc      600

tcccagtggt catccatccg cctgtggaca agccccacct tccagtggct gatccccgac      660

agcgctgaca ccacagctac acccacgcac tgtgcctatg acaggatcgt ggttgcaggg      720

atgctgctcc gaggcgccgt tgttcccgac tcggctcttc cctttaactt ccaggctgcc      780

tatggcctga gtgaccaact ggcccaagcc atcagtgacc actatccagt ggaggtgatg      840

ctgaagtga                                                              849


<210>  2
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Gly Met Lys Leu Leu Gly Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Gln Gly Ala Val Ser Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr 
            20                  25                  30          


Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val 
        35                  40                  45              


Gln Ile Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp 
    50                  55                  60                  


Ser His Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp 
65                  70                  75                  80  


Ala Pro Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn 
                85                  90                  95      


Ser Tyr Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser 
            100                 105                 110         


Ala Val Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn 
        115                 120                 125             


Asp Thr Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe 
    130                 135                 140                 


Thr Glu Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly 
145                 150                 155                 160 


Asp Ala Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val 
                165                 170                 175     


Gln Glu Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn 
            180                 185                 190         


Ala Gly Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu 
        195                 200                 205             


Trp Thr Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr 
    210                 215                 220                 


Thr Ala Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly 
225                 230                 235                 240 


Met Leu Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn 
                245                 250                 255     


Phe Gln Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser 
            260                 265                 270         


Asp His Tyr Pro Val Glu Val Met Leu Lys 
        275                 280         


<210>  3
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F] DNA

<400>  3
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga agagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840


<210>  4
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]

<400>  4

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys 
        275                 280 


<210>  5
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 G105R-A114F] DNA

<400>  5
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga acagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840


<210>  6
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 G105R-A114F]

<400>  6

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys 
        275                 280 


<210>  7
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (gly4ser)4 linker DNA

<400>  7
agatctctcc ggaggaggtg gctcaggtgg tggaggatct ggaggaggtg ggagtggtgg       60

aggtggttct accggtctcg ag                                                82


<210>  8
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (gly4ser)4 linker

<400>  8

Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu 
            20                  25      


<210>  9
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (gly4ser)6 linker DNA

<400>  9
agatctctcc ggaggaggtg gctcaggtgg tggaggatct ggaggaggtg ggagtggtgg       60

aggtggttct ggaggaggtg gtagtggagg tggaggttct accggtctcg ag              112


<210>  10
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (gly4ser)6 linker

<400>  10

Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Thr Gly Leu 
        35      


<210>  11
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 variant Fc DNA (SCC hinge, wild-type CH2 and CH3)

<400>  11
gagcccaaat cttctgacaa aactcacaca tgtccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc tctgtctccg ggtaaa                                696


<210>  12
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 variant Fc (SCC hinge, wild-type CH2 and CH3)

<400>  12

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  13
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 variant Fc DNA (SSS hinge, P238S, P331S)

<400>  13
gagcccaaat cttctgacaa aactcacaca tctccaccgt ccccagcacc tgaactcctg       60

ggaggatcgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcctccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc tctctctccg ggtaaa                                696


<210>  14
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 variant Fc (SSS hinge, P238S, P331S)

<400>  14

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  15
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 variant Fc DNA (SSS hinge, P238S)

<400>  15
gagcccaaat cttctgacaa aactcacaca tctccaccgt ccccagcacc tgaactcctg       60

gggggatcgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc tctgtctccg ggtaaa                                696


<210>  16
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 variant Fc DNA (SSS hinge, P238S)

<400>  16

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  17
<211>  1614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc] DNA

<400>  17
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga agagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840

gatctctccg gaggaggtgg ctcaggtggt ggaggatctg gaggaggtgg gagtggtgga      900

ggtggttcta ccggtctcga gcccaaatct tctgacaaaa ctcacacatc tccaccgtcc      960

ccagcacctg aactcctggg aggatcgtca gtcttcctct tccccccaaa acccaaggac     1020

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1080

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1140

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1200

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1260

gcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1320

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     1380

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1440

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1500

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1560

gaggctctgc acaaccacta cacgcagaag agcctctctc tctctccggg taaa           1614


<210>  18
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N96K-G127R-A136F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]

<400>  18

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
    290                 295                 300                 


Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
305                 310                 315                 320 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        355                 360                 365             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        435                 440                 445             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            500                 505                 510         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    530                 535             


<210>  19
<211>  1644
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)6-[SSShinge-P238S-P331S 
       Fc] DNA

<400>  19
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga agagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840

gatctctccg gaggaggtgg ctcaggtggt ggaggatctg gaggaggtgg gagtggtgga      900

ggtggttctg gaggaggtgg tagtggaggt ggaggttcta ccggtctcga gcccaaatct      960

tctgacaaaa ctcacacatc tccaccgtcc ccagcacctg aactcctggg aggatcgtca     1020

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1080

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1140

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1200

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1260

aagtgcaagg tctccaacaa agccctccca gcctccatcg agaaaaccat ctccaaagcc     1320

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1380

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1440

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1500

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1560

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1620

agcctctctc tctctccggg taaa                                            1644


<210>  20
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N96K-G127R-A136F]-(g4s)6-[SSShinge-P238S-P331S 
       Fc]

<400>  20

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys 
545             


<210>  21
<211>  1099
<212>  DNA
<213>  Homo sapiens

<400>  21
atggcgaagc tgattgcgct caccctcttg gggatgggac tggcactctt caggaaccac       60

cagtcttctt accaaacacg acttaatgct ctccgagagg tacaacccgt agaacttcct      120

aactgtaatt tagttaaagg aatcgaaact ggctctgaag acttggagat actgcctaat      180

ggactggctt tcattagctc tggattaaag tatcctggaa taaagagctt caaccccaac      240

agtcctggaa aaatacttct gatggacctg aatgaagaag atccaacagt gttggaattg      300

gggatcactg gaagtaaatt tgatgtatct tcatttaacc ctcatgggat tagcacattc      360

acagatgaag ataatgccat gtacctcctg gtggtgaacc atccagatgc caagtccaca      420

gtggagttgt ttaaatttca agaagaagaa aaatcgcttt tgcatctaaa aaccatcaga      480

cataaacttc tgcctaattt gaatgatatt gttgctgtgg gacctgagca cttttatggc      540

acaaatgatc actattttct tgacccctac ttacaatcct gggagatgta tttgggttta      600

gcgtggtcgt atgttgtcta ctatagtcca agtgaagttc gagtggtggc agaaggattt      660

gattttgcta atggaatcaa catttcaccc gatggcaagt atgtctatat agctgagttg      720

ctggctcata agattcatgt gtatgaaaag catgctaatt ggactttaac tccattgaag      780

tcccttgact ttaataccct cgtggataac atatctgtgg atcctgagac aggagacctt      840

tgggttggat gccatcccaa tggcatgaaa atcttcttct atgactcaga gaatcctcct      900

gcatcagagg tgcttcgaat ccagaacatt ctaacagaag aacctaaagt gacacaggtt      960

tatgcagaaa atggcacagt gttgcaaggc agtacagttg cctctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctctaaca gaccgatttg     1080

cacccatgcc atagaaact                                                  1099


<210>  22
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Gln 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  23
<211>  1068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PON1 Q192K DNA

<400>  23
atggcgaagc tgattgcgct caccctcttg gggatgggac tggcactctt caggaaccac       60

cagtcttctt accaaacacg acttaatgct ctccgagagg tacaacccgt agaacttcct      120

aactgtaatt tagttaaagg aatcgaaact ggctctgaag acttggagat actgcctaat      180

ggactggctt tcattagctc tggattaaag tatcctggaa taaagagctt caaccccaac      240

agtcctggaa aaatacttct gatggacctg aatgaagaag atccaacagt gttggaattg      300

gggatcactg gaagtaaatt tgatgtatct tcatttaacc ctcatgggat tagcacattc      360

acagatgaag ataatgccat gtacctcctg gtggtgaacc atccagatgc caagtccaca      420

gtggagttgt ttaaatttca agaagaagaa aaatcgcttt tgcatctaaa aaccatcaga      480

cataaacttc tgcctaattt gaatgatatt gttgctgtgg gacctgagca cttttatggc      540

acaaatgatc actattttct tgacccctac ttaaaatcct gggagatgta tttgggttta      600

gcgtggtcgt atgttgtcta ctatagtcca agtgaagttc gagtggtggc agaaggattt      660

gattttgcta atggaatcaa catttcaccc gatggcaagt atgtctatat agctgagttg      720

ctggctcata agattcatgt gtatgaaaag catgctaatt ggactttaac tccattgaag      780

tcccttgact ttaataccct cgtggataac atatctgtgg atcctgagac aggagacctt      840

tgggttggat gccatcccaa tggcatgaaa atcttcttct atgactcaga gaatcctcct      900

gcatcagagg tgcttcgaat ccagaacatt ctaacagaag aacctaaagt gacacaggtt      960

tatgcagaaa atggcacagt gttgcaaggc agtacagttg cctctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctctaa                  1068


<210>  24
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human PON1 Q192K

<400>  24

Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  25
<211>  2713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K] DNA

<400>  25
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gtctgaagat cgcagccttc aacatccaga catttgggga gaccaagatg      120

tccaatgcca ccctcgtcag ctacattgtg cagatcctga gccgctatga catcgccctg      180

gtccaggagg tcagagacag ccacctgact gccgtgggga agctgctgga caacctcaat      240

caggatgcac cagacaccta tcactacgtg gtcagtgagc cactgggacg gaagagctat      300

aaggagcgct acctgttcgt gtacaggcct gaccaggtgt ctgcggtgga cagctactac      360

tacgatgatg gctgcgagcc ctgcaggaac gacaccttca accgagagcc attcattgtc      420

aggttcttct cccggttcac agaggtcagg gagtttgcca ttgttcccct gcatgcggcc      480

ccgggggacg cagtagccga gatcgacgct ctctatgacg tctacctgga tgtccaagag      540

aaatggggct tggaggacgt catgttgatg ggcgacttca atgcgggctg cagctatgtg      600

agaccctccc agtggtcatc catccgcctg tggacaagcc ccaccttcca gtggctgatc      660

cccgacagcg ctgacaccac agctacaccc acgcactgtg cctatgacag gatcgtggtt      720

gcagggatgc tgctccgagg cgccgttgtt cccgactcgg ctcttccctt taacttccag      780

gctgcctatg gcctgagtga ccaactggcc caagccatca gtgaccacta tccagtggag      840

gtgatgctga aagatctctc cggaggaggt ggctcaggtg gtggaggatc tggaggaggt      900

gggagtggtg gaggtggttc taccggtctc gagcccaaat cttctgacaa aactcacaca      960

tctccaccgt ccccagcacc tgaactcctg ggaggatcgt cagtcttcct cttcccccca     1020

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1080

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1140

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1200

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1260

aaagccctcc cagcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1320

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1380

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1440

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1500

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1560

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc tctctctccg     1620

ggtaaagtcg acggagctag cagccccgtg aacgtgagca gccccagcgt gcaggatatc     1680

ctcttcagga accaccagtc ttcttaccaa acacgactta atgctctccg agaggtacaa     1740

cccgtagaac ttcctaactg taatttagtt aaaggaatcg aaactggctc tgaagacttg     1800

gagatactgc ctaatggact ggctttcatt agctctggat taaagtatcc tggaataaag     1860

agcttcaacc ccaacagtcc tggaaaaata cttctgatgg acctgaatga agaagatcca     1920

acagtgttgg aattggggat cactggaagt aaatttgatg tatcttcatt taaccctcat     1980

gggattagca cattcacaga tgaagataat gccatgtacc tcctggtggt gaaccatcca     2040

gatgccaagt ccacagtgga gttgtttaaa tttcaagaag aagaaaaatc gcttttgcat     2100

ctaaaaacca tcagacataa acttctgcct aatttgaatg atattgttgc tgtgggacct     2160

gagcactttt atggcacaaa tgatcactat tttcttgacc cctacttaaa atcctgggag     2220

atgtatttgg gtttagcgtg gtcgtatgtt gtctactata gtccaagtga agttcgagtg     2280

gtggcagaag gatttgattt tgctaatgga atcaacattt cacccgatgg caagtatgtc     2340

tatatagctg agttgctggc tcataagatt catgtgtatg aaaagcatgc taattggact     2400

ttaactccat tgaagtccct tgactttaat accctcgtgg ataacatatc tgtggatcct     2460

gagacaggag acctttgggt tggatgccat cccaatggca tgaaaatctt cttctatgac     2520

tcagagaatc ctcctgcatc agaggtgctt cgaatccaga acattctaac agaagaacct     2580

aaagtgacac aggtttatgc agaaaatggc acagtgttgc aaggcagtac agttgcctct     2640

gtgtacaaag ggaaactgct gattggcaca gtgtttcaca aagctcttta ctgtgagctc     2700

taataatcta gaa                                                        2713


<210>  26
<211>  896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K]

<400>  26

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
    290                 295                 300                 


Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
305                 310                 315                 320 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        355                 360                 365             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        435                 440                 445             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            500                 505                 510         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser 
    530                 535                 540                 


Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Arg Asn 
545                 550                 555                 560 


His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu Val Gln 
                565                 570                 575     


Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile Glu Thr Gly 
            580                 585                 590         


Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser 
        595                 600                 605             


Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly 
    610                 615                 620                 


Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr Val Leu Glu 
625                 630                 635                 640 


Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe Asn Pro His 
                645                 650                 655     


Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu Leu Val 
            660                 665                 670         


Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe Lys Phe Gln 
        675                 680                 685             


Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu 
    690                 695                 700                 


Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr 
705                 710                 715                 720 


Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu 
                725                 730                 735     


Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser 
            740                 745                 750         


Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn 
        755                 760                 765             


Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His 
    770                 775                 780                 


Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu 
785                 790                 795                 800 


Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser Val Asp Pro 
                805                 810                 815     


Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met Lys Ile 
            820                 825                 830         


Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val Leu Arg Ile 
        835                 840                 845             


Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val Tyr Ala Glu 
    850                 855                 860                 


Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val Tyr Lys Gly 
865                 870                 875                 880 


Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
                885                 890                 895     


<210>  27
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  27
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gt                                                           72


<210>  28
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (gly4ser) tandem repeat sequence

<400>  29

Gly Gly Gly Gly Ser 
1               5   


<210>  30
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  30

Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr 
            20                  25                  30          


Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn Asp Thr Phe Asn Arg Glu 
            100                 105                 110         


Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe 
        115                 120                 125             


Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu 
145                 150                 155                 160 


Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val 
                165                 170                 175     


Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala 
    210                 215                 220                 


Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Met Leu Lys 
            260 


<210>  31
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Peptide linker containing N-linked glycosylation site (NGS 
       linker) DNA

<400>  31
gtcgacggag ctagcagccc cgtgaacgtg agcagcccca gcgtgcagga tatc             54


<210>  32
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker containing N-linked glycosylation site (NGS 
       linker)

<400>  32

Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln 
1               5                   10                  15      


Asp Ile 
        


<210>  33
<211>  982
<212>  DNA
<213>  Homo sapiens

<400>  33
atgtcacggg agctggcccc actgctgctt ctcctcctct ccatccacag cgccctggcc       60

atgaggatct gctccttcaa cgtcaggtcc tttggggaaa gcaagcagga agacaagaat      120

gccatggatg tcattgtgaa ggtcatcaaa cgctgtgaca tcatactcgt gatggaaatc      180

aaggacagca acaacaggat ctgccccata ctgatggaga agctgaacag aaattcaagg      240

agaggcataa cgtacaacta tgtgattagc tctcggcttg gaagaaacac atataaagaa      300

caatatgcct ttctctacaa ggaaaagctg gtgtctgtga agaggagtta tcactaccat      360

gactatcagg atggagacgc agatgtgttt tccagggagc cctttgtggt ctggttccaa      420

tctccccaca ctgctgtcaa agacttcgtg attatccccc tgcacaccac cccagagaca      480

tccgttaagg agatcgatga gttggttgag gtctacacgg acgtgaaaca ccgctggaag      540

gcggagaatt tcattttcat gggtgacttc aatgccggct gcagctacgt ccccaagaag      600

gcctggaaga acatccgctt gaggactgac cccaggtttg tttggctgat cggggaccaa      660

gaggacacca cggtgaagaa gagcaccaac tgtgcatatg acaggattgt gcttagagga      720

caagaaatcg tcagttctgt tgttcccaag tcaaacagtg tttttgactt ccagaaagct      780

tacaagctga ctgaagagga ggccctggat gtcagcgacc actttccagt tgaatttaaa      840

ctacagtctt caagggcctt caccaacagc aaaaaatctg tcactctaag gaagaaaaca      900

aagaggaaac gctcctaccc aactttcttg tacaaagttg gcattataag aaagcattgc      960

ttatcaattt gttgcaacga ac                                               982


<210>  34
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His 
1               5                   10                  15      


Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Arg 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Arg Asn 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Lys Lys Ser Val Thr Leu Arg Lys Lys Thr Lys Arg Lys Arg 
    290                 295                 300                 


Ser 
305 


<210>  35
<211>  1647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 NLS1mutAAA, 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc] DNA

<400>  35
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

atgaggatct gctccttcaa cgtcaggtcc tttggggaaa gcaagcagga agacaagaat      120

gccatggatg tcattgtgaa ggtcatcaaa cgctgtgaca tcatactcgt gatggaaatc      180

aaggacagca acaacaggat ctgccccata ctgatggaga agctgaacag aaattcagca      240

agaggcataa cgtacaacta tgtgattagc tctcggcttg gagcagctac atataaagaa      300

caatatgcct ttctctacaa ggaaaagctg gtgtctgtga agaggagtta tcactaccat      360

gactatcagg atggagacgc agatgtgttt tccagggagc cctttgtggt ctggttccaa      420

tctccccaca ctgctgtcaa agacttcgtg attatccccc tgcacaccac cccagagaca      480

tccgttaagg agatcgatga gttggttgag gtctacacgg acgtgaaaca ccgctggaag      540

gcggagaatt tcattttcat gggtgacttc aatgccggct gcagctacgt ccccaagaag      600

gcctggaaga acatccgctt gaggactgac cccaggtttg tttggctgat cggggaccaa      660

gaggacacca cggtgaagaa gagcaccaac tgtgcatatg acaggattgt gcttagagga      720

caagaaatcg tcagttctgt tgttcccaag tcaaacagtg tttttgactt ccagaaagct      780

tacaagctga ctgaagagga ggccctggat gtcagcgacc actttccagt tgaatttaaa      840

ctacagtctt caagggcctt caccaactca gatctctccg gaggaggtgg ctcaggtggt      900

ggaggatctg gaggaggtgg gagtggtgga ggtggttcta ccggtctcga gcccaaatct      960

tctgacaaaa ctcacacatc tccaccgtcc ccagcacctg aactcctggg aggatcgtca     1020

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1080

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1140

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1200

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1260

aagtgcaagg tctccaacaa agccctccca gcctccatcg agaaaaccat ctccaaagcc     1320

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1380

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1440

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1500

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1560

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1620

agcctctctc tctctccggg taaataa                                         1647


<210>  36
<211>  548
<212>  PRT
<213>  Artificial Sequece

<220>
<223>  hVK3LP-[hDNase1L3 NLS1mutAAA, 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc]

<400>  36

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Ala 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Ala Ala 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys 
545             


<210>  37
<211>  1647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 NLS1mutSSS, 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc] DNA

<400>  37
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

atgaggatct gctccttcaa cgtcaggtcc tttggggaaa gcaagcagga agacaagaat      120

gccatggatg tcattgtgaa ggtcatcaaa cgctgtgaca tcatactcgt gatggaaatc      180

aaggacagca acaacaggat ctgccccata ctgatggaga agctgaacag aaattcatca      240

agaggcataa cgtacaacta tgtgattagc tctcggcttg gaagttctac atataaagaa      300

caatatgcct ttctctacaa ggaaaagctg gtgtctgtga agaggagtta tcactaccat      360

gactatcagg atggagacgc agatgtgttt tccagggagc cctttgtggt ctggttccaa      420

tctccccaca ctgctgtcaa agacttcgtg attatccccc tgcacaccac cccagagaca      480

tccgttaagg agatcgatga gttggttgag gtctacacgg acgtgaaaca ccgctggaag      540

gcggagaatt tcattttcat gggtgacttc aatgccggct gcagctacgt ccccaagaag      600

gcctggaaga acatccgctt gaggactgac cccaggtttg tttggctgat cggggaccaa      660

gaggacacca cggtgaagaa gagcaccaac tgtgcatatg acaggattgt gcttagagga      720

caagaaatcg tcagttctgt tgttcccaag tcaaacagtg tttttgactt ccagaaagct      780

tacaagctga ctgaagagga ggccctggat gtcagcgacc actttccagt tgaatttaaa      840

ctacagtctt caagggcctt caccaactca gatctctccg gaggaggtgg ctcaggtggt      900

ggaggatctg gaggaggtgg gagtggtgga ggtggttcta ccggtctcga gcccaaatct      960

tctgacaaaa ctcacacatc tccaccgtcc ccagcacctg aactcctggg aggatcgtca     1020

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1080

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1140

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1200

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1260

aagtgcaagg tctccaacaa agccctccca gcctccatcg agaaaaccat ctccaaagcc     1320

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1380

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1440

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1500

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1560

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1620

agcctctctc tctctccggg taaataa                                         1647


<210>  38
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 NLS1mutSSS, 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc]

<400>  38

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Ser 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Ser Ser 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys 
545             


<210>  39
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PON1 variant G3C9 DNA

<400>  39
atggctaaac tgacagcgct cacactcttg gggctgggat tggcactctt cgatggacag       60

aagtcttctt tccaaacacg atttaatgtt caccgtgaag taactccagt ggaacttcct      120

aactgtaatt tagttaaagg ggttgacaat ggttctgaag acttggaaat actgcccaat      180

ggactggctt tcatcagctc cggattaaag tatcctggaa taatgagctt tgaccctgat      240

aagtctggaa agatacttct aatggacctg aatgaggaag acccagtagt gttggaactg      300

ggcattactg gaaatacatt ggatatatct tcatttaacc ctcatgggat tagcacattc      360

acagatgaag ataacactgt gtacctactg gtggtaaacc atccagactc ctcgtccacc      420

gtggaggtgt ttaaatttca agaagaagaa aaatcacttt tgcatctgaa aaccatcaga      480

cacaagcttc tgcctagtgt gaatgacatt gtcgctgtgg gacctgaaca cttttatgcc      540

acaaatgatc actattttgc tgacccttac ttaaaatcct gggaaatgca tttgggatta      600

gcgtggtcat ttgttactta ttatagtccc aatgatgttc gagtagtggc agaaggattt      660

gattttgcta acggaatcaa catctcacca gacggcaagt atgtctatat agctgagttg      720

ctggctcata agatccatgt gtatgaaaag cacgctaatt ggactttaac tccattgaag      780

tccctcgact ttgacaccct tgtggataac atctctgtgg atcctgtgac aggggacctc      840

tgggtgggat gccatcccaa cggaatgcga atcttctact atgacccaaa gaatcctccc      900

ggctcagagg tgcttcgaat ccaggacatt ttatccgaag agcccaaagt gacagtggtt      960

tatgcagaaa atggcactgt gttacagggc agcacggtgg ccgctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctg                     1065


<210>  40
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human PON1 variant G3C9

<400>  40

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  41
<211>  1065
<212>  DNA
<213>  PON1 variant M-IIG1 DNA

<400>  41
atggctaaac tgacagcgct cacactcttg gggctgggat tggcactctt cgatggacag       60

aagtcttctt tccaaacacg atttaatgtt caccgtgaag taactccagt ggaacttcct      120

aactgtaatt tagttaaagg ggttgacaat ggttctgaag acattgaaat actgcccaat      180

ggactggctt tcatcagctc cggagttaag tatcctggaa taatgagctt tgaccctgat      240

aagtctggaa agatacttct aatggacctg aatgaggaag acccagtagt gttggaactg      300

ggcattactg gaaatacatt ggatatatct tcatttaacc ctgctgggat tagcacattc      360

acagatgaag ataacactgt gtacctactg gtggtaaacc gaccagactc ctcgtccacc      420

gtggaggtgt ttaaatttca agaagaagaa aaatcacttt tgcatctgaa aaccatcaga      480

cacaagcttc tgcctagtgt gaatgacatt gtcgctgtgg gacctgaaca cttttatgcc      540

acaaatgatc actattttgc tgacccttac ttaaaatcct gggaaatgca tttgggatta      600

gcgtggtcat ttgttactta ttatagtccc aatgatgttc gagtagtggc agaaggattt      660

gatatggcta acggaatcaa catctcacca gacggcaagt atgtctatat agctgagttg      720

ctggctcata agatccatgt gtatgaaaag cacgctaatt ggactttaac tccattgaag      780

tccctcgact ttgacaccct tgtggataac atctctgtgg atcctgtgac aggggacctc      840

tgggtgggat gccatcccaa cggaatgcga ttattctact atgacccaaa gaatcctccc      900

ggctcagagg tgcttcgaat ccaggacatt ttatccgaag agcccaaagt gacagtggtt      960

tatgcagaaa atggcactgt gttacagggc agcagtgtgg ccgctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctg                     1065


<210>  42
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PON1 variant M-IIG1

<400>  42

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Ile Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Ala Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Leu Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  43
<211>  2713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[G3C9 PON1] DNA

<400>  43
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gtctgaagat cgcagccttc aacatccaga catttgggga gaccaagatg      120

tccaatgcca ccctcgtcag ctacattgtg cagatcctga gccgctatga catcgccctg      180

gtccaggagg tcagagacag ccacctgact gccgtgggga agctgctgga caacctcaat      240

caggatgcac cagacaccta tcactacgtg gtcagtgagc cactgggacg gaagagctat      300

aaggagcgct acctgttcgt gtacaggcct gaccaggtgt ctgcggtgga cagctactac      360

tacgatgatg gctgcgagcc ctgcaggaac gacaccttca accgagagcc attcattgtc      420

aggttcttct cccggttcac agaggtcagg gagtttgcca ttgttcccct gcatgcggcc      480

ccgggggacg cagtagccga gatcgacgct ctctatgacg tctacctgga tgtccaagag      540

aaatggggct tggaggacgt catgttgatg ggcgacttca atgcgggctg cagctatgtg      600

agaccctccc agtggtcatc catccgcctg tggacaagcc ccaccttcca gtggctgatc      660

cccgacagcg ctgacaccac agctacaccc acgcactgtg cctatgacag gatcgtggtt      720

gcagggatgc tgctccgagg cgccgttgtt cccgactcgg ctcttccctt taacttccag      780

gctgcctatg gcctgagtga ccaactggcc caagccatca gtgaccacta tccagtggag      840

gtgatgctga aagatctctc cggaggaggt ggctcaggtg gtggaggatc tggaggaggt      900

gggagtggtg gaggtggttc taccggtctc gagcccaaat cttctgacaa aactcacaca      960

tctccaccgt ccccagcacc tgaactcctg ggaggatcgt cagtcttcct cttcccccca     1020

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1080

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1140

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1200

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1260

aaagccctcc cagcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1320

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1380

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1440

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1500

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1560

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc tctctctccg     1620

ggtaaagtcg acggagctag cagccccgtg aacgtgagca gccccagcgt gcaggatatc     1680

ctcttcgatg gacagaagtc ttctttccaa acacgattta atgttcaccg tgaagtaact     1740

ccagtggaac ttcctaactg taatttagtt aaaggggttg acaatggttc tgaagacttg     1800

gaaatactgc ccaatggact ggctttcatc agctccggat taaagtatcc tggaataatg     1860

agctttgacc ctgataagtc tggaaagata cttctaatgg acctgaatga ggaagaccca     1920

gtagtgttgg aactgggcat tactggaaat acattggata tatcttcatt taaccctcat     1980

gggattagca cattcacaga tgaagataac actgtgtacc tactggtggt aaaccatcca     2040

gactcctcgt ccaccgtgga ggtgtttaaa tttcaagaag aagaaaaatc acttttgcat     2100

ctgaaaacca tcagacacaa gcttctgcct agtgtgaatg acattgtcgc tgtgggacct     2160

gaacactttt atgccacaaa tgatcactat tttgctgacc cttacttaaa atcctgggaa     2220

atgcatttgg gattagcgtg gtcatttgtt acttattata gtcccaatga tgttcgagta     2280

gtggcagaag gatttgattt tgctaacgga atcaacatct caccagacgg caagtatgtc     2340

tatatagctg agttgctggc tcataagatc catgtgtatg aaaagcacgc taattggact     2400

ttaactccat tgaagtccct cgactttgac acccttgtgg ataacatctc tgtggatcct     2460

gtgacagggg acctctgggt gggatgccat cccaacggaa tgcgaatctt ctactatgac     2520

ccaaagaatc ctcccggctc agaggtgctt cgaatccagg acattttatc cgaagagccc     2580

aaagtgacag tggtttatgc agaaaatggc actgtgttac agggcagcac ggtggccgct     2640

gtgtacaaag ggaaactgct gattggcaca gtgtttcaca aagctcttta ctgtgagctg     2700

taataatcta gaa                                                        2713


<210>  44
<211>  896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[G3C9 PON1]

<400>  44

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
    290                 295                 300                 


Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
305                 310                 315                 320 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        355                 360                 365             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        435                 440                 445             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            500                 505                 510         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser 
    530                 535                 540                 


Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Asp Gly 
545                 550                 555                 560 


Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg Glu Val Thr 
                565                 570                 575     


Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val Asp Asn Gly 
            580                 585                 590         


Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser 
        595                 600                 605             


Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp Lys Ser Gly 
    610                 615                 620                 


Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val Val Leu Glu 
625                 630                 635                 640 


Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe Asn Pro His 
                645                 650                 655     


Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr Leu Leu Val 
            660                 665                 670         


Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe Lys Phe Gln 
        675                 680                 685             


Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu 
    690                 695                 700                 


Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr 
705                 710                 715                 720 


Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys Ser Trp Glu 
                725                 730                 735     


Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr Ser Pro Asn 
            740                 745                 750         


Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn 
        755                 760                 765             


Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His 
    770                 775                 780                 


Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu 
785                 790                 795                 800 


Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser Val Asp Pro 
                805                 810                 815     


Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met Arg Ile 
            820                 825                 830         


Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val Leu Arg Ile 
        835                 840                 845             


Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val Tyr Ala Glu 
    850                 855                 860                 


Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val Tyr Lys Gly 
865                 870                 875                 880 


Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
                885                 890                 895     


<210>  45
<211>  2688
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[M-IIG1 PON1] DNA

<400>  45
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga agagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840

gatctctccg gaggaggtgg ctcaggtggt ggaggatctg gaggaggtgg gagtggtgga      900

ggtggttcta ccggtctcga gcccaaatct tctgacaaaa ctcacacatc tccaccgtcc      960

ccagcacctg aactcctggg aggatcgtca gtcttcctct tccccccaaa acccaaggac     1020

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1080

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1140

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1200

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1260

gcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1320

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     1380

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1440

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1500

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1560

gaggctctgc acaaccacta cacgcagaag agcctctctc tctctccggg taaagtcgac     1620

ggagctagca gccccgtgaa cgtgagcagc cccagcgtgc aggatatcct cttcgatgga     1680

cagaagtctt ctttccaaac acgatttaat gttcaccgtg aagtaactcc agtggaactt     1740

cctaactgta atttagttaa aggggttgac aatggttctg aagacattga aatactgccc     1800

aatggactgg ctttcatcag ctccggagtt aagtatcctg gaataatgag ctttgaccct     1860

gataagtctg gaaagatact tctaatggac ctgaatgagg aagacccagt agtgttggaa     1920

ctgggcatta ctggaaatac attggatata tcttcattta accctgctgg gattagcaca     1980

ttcacagatg aagataacac tgtgtaccta ctggtggtaa accgaccaga ctcctcgtcc     2040

accgtggagg tgtttaaatt tcaagaagaa gaaaaatcac ttttgcatct gaaaaccatc     2100

agacacaagc ttctgcctag tgtgaatgac attgtcgctg tgggacctga acacttttat     2160

gccacaaatg atcactattt tgctgaccct tacttaaaat cctgggaaat gcatttggga     2220

ttagcgtggt catttgttac ttattatagt cccaatgatg ttcgagtagt ggcagaagga     2280

tttgatatgg ctaacggaat caacatctca ccagacggca agtatgtcta tatagctgag     2340

ttgctggctc ataagatcca tgtgtatgaa aagcacgcta attggacttt aactccattg     2400

aagtccctcg actttgacac ccttgtggat aacatctctg tggatcctgt gacaggggac     2460

ctctgggtgg gatgccatcc caacggaatg cgattattct actatgaccc aaagaatcct     2520

cccggctcag aggtgcttcg aatccaggac attttatccg aagagcccaa agtgacagtg     2580

gtttatgcag aaaatggcac tgtgttacag ggcagcagtg tggccgctgt gtacaaaggg     2640

aaactgctga ttggcacagt gtttcacaaa gctctttact gtgagctg                  2688


<210>  46
<211>  896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[M-IIG1 PON1]

<400>  46

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
    290                 295                 300                 


Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
305                 310                 315                 320 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        355                 360                 365             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        435                 440                 445             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            500                 505                 510         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser 
    530                 535                 540                 


Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Asp Gly 
545                 550                 555                 560 


Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg Glu Val Thr 
                565                 570                 575     


Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val Asp Asn Gly 
            580                 585                 590         


Ser Glu Asp Ile Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser 
        595                 600                 605             


Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp Lys Ser Gly 
    610                 615                 620                 


Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val Val Leu Glu 
625                 630                 635                 640 


Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe Asn Pro Ala 
                645                 650                 655     


Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr Leu Leu Val 
            660                 665                 670         


Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe Lys Phe Gln 
        675                 680                 685             


Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu 
    690                 695                 700                 


Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr 
705                 710                 715                 720 


Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys Ser Trp Glu 
                725                 730                 735     


Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr Ser Pro Asn 
            740                 745                 750         


Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn Gly Ile Asn 
        755                 760                 765             


Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His 
    770                 775                 780                 


Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu 
785                 790                 795                 800 


Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser Val Asp Pro 
                805                 810                 815     


Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met Arg Leu 
            820                 825                 830         


Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val Leu Arg Ile 
        835                 840                 845             


Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val Tyr Ala Glu 
    850                 855                 860                 


Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val Tyr Lys Gly 
865                 870                 875                 880 


Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
                885                 890                 895     


<210>  47
<211>  2721
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)6-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K] DNA

<400>  47
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga agagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840

gatctctccg gaggaggtgg ctcaggtggt ggaggatctg gaggaggtgg gagtggtgga      900

ggtggttctg gaggaggtgg tagtggaggt ggaggttcta ccggtctcga gcccaaatct      960

tctgacaaaa ctcacacatc tccaccgtcc ccagcacctg aactcctggg aggatcgtca     1020

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1080

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1140

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1200

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1260

aagtgcaagg tctccaacaa agccctccca gcctccatcg agaaaaccat ctccaaagcc     1320

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1380

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1440

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1500

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1560

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1620

agcctctctc tctctccggg taaagtcgac ggagctagca gccccgtgaa cgtgagcagc     1680

cccagcgtgc aggatatcct cttcaggaac caccagtctt cttaccaaac acgacttaat     1740

gctctccgag aggtacaacc cgtagaactt cctaactgta atttagttaa aggaatcgaa     1800

actggctctg aagacttgga gatactgcct aatggactgg ctttcattag ctctggatta     1860

aagtatcctg gaataaagag cttcaacccc aacagtcctg gaaaaatact tctgatggac     1920

ctgaatgaag aagatccaac agtgttggaa ttggggatca ctggaagtaa atttgatgta     1980

tcttcattta accctcatgg gattagcaca ttcacagatg aagataatgc catgtacctc     2040

ctggtggtga accatccaga tgccaagtcc acagtggagt tgtttaaatt tcaagaagaa     2100

gaaaaatcgc ttttgcatct aaaaaccatc agacataaac ttctgcctaa tttgaatgat     2160

attgttgctg tgggacctga gcacttttat ggcacaaatg atcactattt tcttgacccc     2220

tacttaaaat cctgggagat gtatttgggt ttagcgtggt cgtatgttgt ctactatagt     2280

ccaagtgaag ttcgagtggt ggcagaagga tttgattttg ctaatggaat caacatttca     2340

cccgatggca agtatgtcta tatagctgag ttgctggctc ataagattca tgtgtatgaa     2400

aagcatgcta attggacttt aactccattg aagtcccttg actttaatac cctcgtggat     2460

aacatatctg tggatcctga gacaggagac ctttgggttg gatgccatcc caatggcatg     2520

aaaatcttct tctatgactc agagaatcct cctgcatcag aggtgcttcg aatccagaac     2580

attctaacag aagaacctaa agtgacacag gtttatgcag aaaatggcac agtgttgcaa     2640

ggcagtacag ttgcctctgt gtacaaaggg aaactgctga ttggcacagt gtttcacaaa     2700

gctctttact gtgagctcta a                                               2721


<210>  48
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)6-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K]

<400>  48

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser 
545                 550                 555                 560 


Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser Tyr Gln 
                565                 570                 575     


Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu Pro Asn 
            580                 585                 590         


Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile 
        595                 600                 605             


Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly 
    610                 615                 620                 


Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu Met Asp 
625                 630                 635                 640 


Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr Gly Ser 
                645                 650                 655     


Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr 
            660                 665                 670         


Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His Pro Asp Ala 
        675                 680                 685             


Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu 
    690                 695                 700                 


Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu Asn Asp 
705                 710                 715                 720 


Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp His Tyr 
                725                 730                 735     


Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala 
            740                 745                 750         


Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val Val Ala 
        755                 760                 765             


Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys 
    770                 775                 780                 


Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His Val Tyr Glu 
785                 790                 795                 800 


Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn 
                805                 810                 815     


Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp Leu Trp 
            820                 825                 830         


Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu 
        835                 840                 845             


Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu Thr Glu 
    850                 855                 860                 


Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val Leu Gln 
865                 870                 875                 880 


Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr 
                885                 890                 895     


Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
            900                 905     


<210>  49
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [hDNase1 N74X-G105X-A114X]-[gs linker]-[SSShinge Fc]


<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa is Lys, Arg, or His

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa is Lys, Arg, or His

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  Xaa is Phe, Glu, Met, Arg, or Tyr

<220>
<221>  MISC_FEATURE
<222>  (261)..(263)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (264)..(283)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (284)..(293)
<223>  Xaa is Gly or Ser or is absent

<220>
<221>  MISC_FEATURE
<222>  (294)..(296)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (315)..(316)
<223>  Xaa is Leu or Ala

<220>
<221>  MISC_FEATURE
<222>  (319)..(319)
<223>  Xaa is Pro or Ser

<220>
<221>  MISC_FEATURE
<222>  (333)..(333)
<223>  Xaa is Met or Tyr

<220>
<221>  MISC_FEATURE
<222>  (335)..(335)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (337)..(337)
<223>  Xaa is Thr or Glu

<220>
<221>  MISC_FEATURE
<222>  (346)..(346)
<223>  Xaa is Asp or Ala

<220>
<221>  MISC_FEATURE
<222>  (378)..(378)
<223>  Xaa is Asn, Ala, Gln, or Gly

<220>
<221>  MISC_FEATURE
<222>  (410)..(410)
<223>  Xaa is Pro, Ala, Gly, or Ser

<220>
<221>  MISC_FEATURE
<222>  (412)..(412)
<223>  Xaa is Pro, Ser, or Ala

<220>
<221>  MISC_FEATURE
<222>  (509)..(509)
<223>  Xaa is Met or Leu

<220>
<221>  MISC_FEATURE
<222>  (515)..(515)
<223>  Xaa is Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (528)..(528)
<223>  Xaa is Lys or is absent

<400>  49

Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr 
            20                  25                  30          


Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Xaa Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Pro Cys Xaa Asn Asp Thr Phe Asn Arg Glu 
            100                 105                 110         


Pro Xaa Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe 
        115                 120                 125             


Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu 
145                 150                 155                 160 


Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val 
                165                 170                 175     


Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala 
    210                 215                 220                 


Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Met Leu Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Pro Lys Ser Ser Asp Lys Thr 
    290                 295                 300                 


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Xaa Xaa Gly Gly Xaa Ser 
305                 310                 315                 320 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Xaa Ile Xaa Arg 
                325                 330                 335     


Xaa Pro Glu Val Thr Cys Val Val Val Xaa Val Ser His Glu Asp Pro 
            340                 345                 350         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        355                 360                 365             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val Val 
    370                 375                 380                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
385                 390                 395                 400 


Lys Cys Lys Val Ser Asn Lys Ala Leu Xaa Ala Xaa Ile Glu Lys Thr 
                405                 410                 415     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            420                 425                 430         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        435                 440                 445             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    450                 455                 460                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
465                 470                 475                 480 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                485                 490                 495     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Xaa His Glu Ala 
            500                 505                 510         


Leu His Xaa His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        515                 520                 525             


<210>  50
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [hDNase1 N74K-G105R-A114F]-[gs linker]-[SSShinge Fc]


<220>
<221>  MISC_FEATURE
<222>  (261)..(263)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (264)..(283)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (284)..(293)
<223>  Xaa is Gly or Ser or is absent

<220>
<221>  MISC_FEATURE
<222>  (294)..(296)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (315)..(316)
<223>  Xaa is Leu or Ala

<220>
<221>  MISC_FEATURE
<222>  (319)..(319)
<223>  Xaa is Pro or Ser

<220>
<221>  MISC_FEATURE
<222>  (333)..(333)
<223>  Xaa is Met or Tyr

<220>
<221>  MISC_FEATURE
<222>  (335)..(335)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (337)..(337)
<223>  Xaa is Thr or Glu

<220>
<221>  MISC_FEATURE
<222>  (346)..(346)
<223>  Xaa is Asp or Ala

<220>
<221>  MISC_FEATURE
<222>  (378)..(378)
<223>  Xaa is Asn, Ala, Gln, or Gly

<220>
<221>  MISC_FEATURE
<222>  (410)..(410)
<223>  Xaa is Pro, Ala, Gly, or Ser

<220>
<221>  MISC_FEATURE
<222>  (412)..(412)
<223>  Xaa is Pro, Ser, or Ala

<220>
<221>  MISC_FEATURE
<222>  (509)..(509)
<223>  Xaa is Met or Leu

<220>
<221>  MISC_FEATURE
<222>  (515)..(515)
<223>  Xaa is Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (528)..(528)
<223>  Xaa is Lys or is absent

<400>  50

Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr 
            20                  25                  30          


Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr Phe Asn Arg Glu 
            100                 105                 110         


Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe 
        115                 120                 125             


Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu 
145                 150                 155                 160 


Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val 
                165                 170                 175     


Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala 
    210                 215                 220                 


Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Met Leu Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Pro Lys Ser Ser Asp Lys Thr 
    290                 295                 300                 


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Xaa Xaa Gly Gly Xaa Ser 
305                 310                 315                 320 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Xaa Ile Xaa Arg 
                325                 330                 335     


Xaa Pro Glu Val Thr Cys Val Val Val Xaa Val Ser His Glu Asp Pro 
            340                 345                 350         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        355                 360                 365             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val Val 
    370                 375                 380                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
385                 390                 395                 400 


Lys Cys Lys Val Ser Asn Lys Ala Leu Xaa Ala Xaa Ile Glu Lys Thr 
                405                 410                 415     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            420                 425                 430         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        435                 440                 445             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    450                 455                 460                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
465                 470                 475                 480 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                485                 490                 495     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Xaa His Glu Ala 
            500                 505                 510         


Leu His Xaa His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        515                 520                 525             


<210>  51
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R] DNA

<400>  51
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga agagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccag ccattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840


<210>  52
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R]

<400>  52

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys 
        275                 280 


<210>  53
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [hDNase1 N74X-G105X]-[gs linker]-[SSShinge Fc]


<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa is Lys, Arg, or His

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa is Lys, Arg, or His

<220>
<221>  MISC_FEATURE
<222>  (261)..(263)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (264)..(283)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (284)..(293)
<223>  Xaa is Gly or Ser or is absent

<220>
<221>  MISC_FEATURE
<222>  (294)..(296)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (315)..(316)
<223>  Xaa is Leu or Ala

<220>
<221>  MISC_FEATURE
<222>  (319)..(319)
<223>  Xaa is Pro or Ser

<220>
<221>  MISC_FEATURE
<222>  (333)..(333)
<223>  Xaa is Met or Tyr

<220>
<221>  MISC_FEATURE
<222>  (335)..(335)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (337)..(337)
<223>  Xaa is Thr or Glu

<220>
<221>  MISC_FEATURE
<222>  (346)..(346)
<223>  Xaa is Asp or Ala

<220>
<221>  MISC_FEATURE
<222>  (378)..(378)
<223>  Xaa is Asn, Ala, Gly, or Ser

<220>
<221>  MISC_FEATURE
<222>  (410)..(410)
<223>  Xaa is Pro, Ala, Gly, or Ser

<220>
<221>  MISC_FEATURE
<222>  (412)..(412)
<223>  Xaa is Pro, Ser, or Ala

<220>
<221>  MISC_FEATURE
<222>  (509)..(509)
<223>  Xaa is Met or Leu

<220>
<221>  MISC_FEATURE
<222>  (515)..(515)
<223>  Xaa is Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (528)..(528)
<223>  Xaa is Lys or is absent

<400>  53

Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr 
            20                  25                  30          


Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Xaa Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Pro Cys Xaa Asn Asp Thr Phe Asn Arg Glu 
            100                 105                 110         


Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe 
        115                 120                 125             


Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu 
145                 150                 155                 160 


Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val 
                165                 170                 175     


Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala 
    210                 215                 220                 


Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Met Leu Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Pro Lys Ser Ser Asp Lys Thr 
    290                 295                 300                 


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Xaa Xaa Gly Gly Xaa Ser 
305                 310                 315                 320 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Xaa Ile Xaa Arg 
                325                 330                 335     


Xaa Pro Glu Val Thr Cys Val Val Val Xaa Val Ser His Glu Asp Pro 
            340                 345                 350         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        355                 360                 365             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val Val 
    370                 375                 380                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
385                 390                 395                 400 


Lys Cys Lys Val Ser Asn Lys Ala Leu Xaa Ala Xaa Ile Glu Lys Thr 
                405                 410                 415     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            420                 425                 430         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        435                 440                 445             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    450                 455                 460                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
465                 470                 475                 480 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                485                 490                 495     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Xaa His Glu Ala 
            500                 505                 510         


Leu His Xaa His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        515                 520                 525             


<210>  54
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [hDNase1 N74K-G105R]-[gs linker]-[SSShinge Fc]


<220>
<221>  MISC_FEATURE
<222>  (261)..(263)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (264)..(283)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (284)..(293)
<223>  Xaa is Gly or Ser or is absent

<220>
<221>  MISC_FEATURE
<222>  (294)..(296)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (315)..(316)
<223>  Xaa is Leu or Ala

<220>
<221>  MISC_FEATURE
<222>  (319)..(319)
<223>  Xaa is Pro or Ser

<220>
<221>  MISC_FEATURE
<222>  (333)..(333)
<223>  Xaa is Met or Tyr

<220>
<221>  MISC_FEATURE
<222>  (335)..(335)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (337)..(337)
<223>  Xaa is Thr or Glu

<220>
<221>  MISC_FEATURE
<222>  (346)..(346)
<223>  Xaa is Asp or Ala

<220>
<221>  MISC_FEATURE
<222>  (378)..(378)
<223>  Xaa is Asn, Ala, Gln, or Gly

<220>
<221>  MISC_FEATURE
<222>  (410)..(410)
<223>  Xaa is Pro, Ala, Gly, or Ser

<220>
<221>  MISC_FEATURE
<222>  (412)..(412)
<223>  Xaa is Pro, Ser, or Ala

<220>
<221>  MISC_FEATURE
<222>  (509)..(509)
<223>  Xaa is Met or Leu

<220>
<221>  misc_feature
<222>  (515)..(515)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (528)..(528)
<223>  Xaa is Lys or is absent

<400>  54

Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr 
            20                  25                  30          


Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr Phe Asn Arg Glu 
            100                 105                 110         


Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe 
        115                 120                 125             


Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu 
145                 150                 155                 160 


Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val 
                165                 170                 175     


Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala 
    210                 215                 220                 


Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Met Leu Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Pro Lys Ser Ser Asp Lys Thr 
    290                 295                 300                 


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Xaa Xaa Gly Gly Xaa Ser 
305                 310                 315                 320 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Xaa Ile Xaa Arg 
                325                 330                 335     


Xaa Pro Glu Val Thr Cys Val Val Val Xaa Val Ser His Glu Asp Pro 
            340                 345                 350         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        355                 360                 365             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val Val 
    370                 375                 380                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
385                 390                 395                 400 


Lys Cys Lys Val Ser Asn Lys Ala Leu Xaa Ala Xaa Ile Glu Lys Thr 
                405                 410                 415     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            420                 425                 430         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        435                 440                 445             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    450                 455                 460                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
465                 470                 475                 480 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                485                 490                 495     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Xaa His Glu Ala 
            500                 505                 510         


Leu His Xaa His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        515                 520                 525             


<210>  55
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N96K-G127R]-(g4s)4-[SSShinge-P238S-P331S Fc]

<400>  55

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
    290                 295                 300                 


Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
305                 310                 315                 320 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        355                 360                 365             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        435                 440                 445             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            500                 505                 510         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    530                 535             


<210>  56
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N96K-G127R]-(g4s)6-[SSShinge-P238S-P331S Fc]

<400>  56

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys 
545             


<210>  57
<211>  2713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K] DNA

<400>  57
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gtctgaagat cgcagccttc aacatccaga catttgggga gaccaagatg      120

tccaatgcca ccctcgtcag ctacattgtg cagatcctga gccgctatga catcgccctg      180

gtccaggagg tcagagacag ccacctgact gccgtgggga agctgctgga caacctcaat      240

caggatgcac cagacaccta tcactacgtg gtcagtgagc cactgggacg gaagagctat      300

aaggagcgct acctgttcgt gtacaggcct gaccaggtgt ctgcggtgga cagctactac      360

tacgatgatg gctgcgagcc ctgcaggaac gacaccttca accgagagcc agccattgtc      420

aggttcttct cccggttcac agaggtcagg gagtttgcca ttgttcccct gcatgcggcc      480

ccgggggacg cagtagccga gatcgacgct ctctatgacg tctacctgga tgtccaagag      540

aaatggggct tggaggacgt catgttgatg ggcgacttca atgcgggctg cagctatgtg      600

agaccctccc agtggtcatc catccgcctg tggacaagcc ccaccttcca gtggctgatc      660

cccgacagcg ctgacaccac agctacaccc acgcactgtg cctatgacag gatcgtggtt      720

gcagggatgc tgctccgagg cgccgttgtt cccgactcgg ctcttccctt taacttccag      780

gctgcctatg gcctgagtga ccaactggcc caagccatca gtgaccacta tccagtggag      840

gtgatgctga aagatctctc cggaggaggt ggctcaggtg gtggaggatc tggaggaggt      900

gggagtggtg gaggtggttc taccggtctc gagcccaaat cttctgacaa aactcacaca      960

tctccaccgt ccccagcacc tgaactcctg ggaggatcgt cagtcttcct cttcccccca     1020

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1080

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1140

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1200

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1260

aaagccctcc cagcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1320

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1380

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1440

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1500

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1560

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc tctctctccg     1620

ggtaaagtcg acggagctag cagccccgtg aacgtgagca gccccagcgt gcaggatatc     1680

ctcttcagga accaccagtc ttcttaccaa acacgactta atgctctccg agaggtacaa     1740

cccgtagaac ttcctaactg taatttagtt aaaggaatcg aaactggctc tgaagacttg     1800

gagatactgc ctaatggact ggctttcatt agctctggat taaagtatcc tggaataaag     1860

agcttcaacc ccaacagtcc tggaaaaata cttctgatgg acctgaatga agaagatcca     1920

acagtgttgg aattggggat cactggaagt aaatttgatg tatcttcatt taaccctcat     1980

gggattagca cattcacaga tgaagataat gccatgtacc tcctggtggt gaaccatcca     2040

gatgccaagt ccacagtgga gttgtttaaa tttcaagaag aagaaaaatc gcttttgcat     2100

ctaaaaacca tcagacataa acttctgcct aatttgaatg atattgttgc tgtgggacct     2160

gagcactttt atggcacaaa tgatcactat tttcttgacc cctacttaaa atcctgggag     2220

atgtatttgg gtttagcgtg gtcgtatgtt gtctactata gtccaagtga agttcgagtg     2280

gtggcagaag gatttgattt tgctaatgga atcaacattt cacccgatgg caagtatgtc     2340

tatatagctg agttgctggc tcataagatt catgtgtatg aaaagcatgc taattggact     2400

ttaactccat tgaagtccct tgactttaat accctcgtgg ataacatatc tgtggatcct     2460

gagacaggag acctttgggt tggatgccat cccaatggca tgaaaatctt cttctatgac     2520

tcagagaatc ctcctgcatc agaggtgctt cgaatccaga acattctaac agaagaacct     2580

aaagtgacac aggtttatgc agaaaatggc acagtgttgc aaggcagtac agttgcctct     2640

gtgtacaaag ggaaactgct gattggcaca gtgtttcaca aagctcttta ctgtgagctc     2700

taataatcta gaa                                                        2713


<210>  58
<211>  896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K]

<400>  58

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
    290                 295                 300                 


Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
305                 310                 315                 320 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        355                 360                 365             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        435                 440                 445             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            500                 505                 510         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser 
    530                 535                 540                 


Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Arg Asn 
545                 550                 555                 560 


His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu Val Gln 
                565                 570                 575     


Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile Glu Thr Gly 
            580                 585                 590         


Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser 
        595                 600                 605             


Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly 
    610                 615                 620                 


Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr Val Leu Glu 
625                 630                 635                 640 


Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe Asn Pro His 
                645                 650                 655     


Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu Leu Val 
            660                 665                 670         


Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe Lys Phe Gln 
        675                 680                 685             


Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu 
    690                 695                 700                 


Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr 
705                 710                 715                 720 


Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu 
                725                 730                 735     


Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser 
            740                 745                 750         


Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn 
        755                 760                 765             


Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His 
    770                 775                 780                 


Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu 
785                 790                 795                 800 


Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser Val Asp Pro 
                805                 810                 815     


Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met Lys Ile 
            820                 825                 830         


Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val Leu Arg Ile 
        835                 840                 845             


Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val Tyr Ala Glu 
    850                 855                 860                 


Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val Tyr Lys Gly 
865                 870                 875                 880 


Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
                885                 890                 895     


<210>  59
<211>  2743
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R]-(g4s)6-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K] DNA

<400>  59
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gtctgaagat cgcagccttc aacatccaga catttgggga gaccaagatg      120

tccaatgcca ccctcgtcag ctacattgtg cagatcctga gccgctatga catcgccctg      180

gtccaggagg tcagagacag ccacctgact gccgtgggga agctgctgga caacctcaat      240

caggatgcac cagacaccta tcactacgtg gtcagtgagc cactgggacg gaagagctat      300

aaggagcgct acctgttcgt gtacaggcct gaccaggtgt ctgcggtgga cagctactac      360

tacgatgatg gctgcgagcc ctgcaggaac gacaccttca accgagagcc agccattgtc      420

aggttcttct cccggttcac agaggtcagg gagtttgcca ttgttcccct gcatgcggcc      480

ccgggggacg cagtagccga gatcgacgct ctctatgacg tctacctgga tgtccaagag      540

aaatggggct tggaggacgt catgttgatg ggcgacttca atgcgggctg cagctatgtg      600

agaccctccc agtggtcatc catccgcctg tggacaagcc ccaccttcca gtggctgatc      660

cccgacagcg ctgacaccac agctacaccc acgcactgtg cctatgacag gatcgtggtt      720

gcagggatgc tgctccgagg cgccgttgtt cccgactcgg ctcttccctt taacttccag      780

gctgcctatg gcctgagtga ccaactggcc caagccatca gtgaccacta tccagtggag      840

gtgatgctga aagatctctc cggaggaggt ggctcaggtg gtggaggatc tggaggaggt      900

gggagtggtg gaggtggttc tggaggaggt ggtagtggag gtggaggttc taccggtctc      960

gagcccaaat cttctgacaa aactcacaca tctccaccgt ccccagcacc tgaactcctg     1020

ggaggatcgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1080

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1140

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1200

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1260

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcctccat cgagaaaacc     1320

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1380

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1440

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1500

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1560

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1620

tacacgcaga agagcctctc tctctctccg ggtaaagtcg acggagctag cagccccgtg     1680

aacgtgagca gccccagcgt gcaggatatc ctcttcagga accaccagtc ttcttaccaa     1740

acacgactta atgctctccg agaggtacaa cccgtagaac ttcctaactg taatttagtt     1800

aaaggaatcg aaactggctc tgaagacttg gagatactgc ctaatggact ggctttcatt     1860

agctctggat taaagtatcc tggaataaag agcttcaacc ccaacagtcc tggaaaaata     1920

cttctgatgg acctgaatga agaagatcca acagtgttgg aattggggat cactggaagt     1980

aaatttgatg tatcttcatt taaccctcat gggattagca cattcacaga tgaagataat     2040

gccatgtacc tcctggtggt gaaccatcca gatgccaagt ccacagtgga gttgtttaaa     2100

tttcaagaag aagaaaaatc gcttttgcat ctaaaaacca tcagacataa acttctgcct     2160

aatttgaatg atattgttgc tgtgggacct gagcactttt atggcacaaa tgatcactat     2220

tttcttgacc cctacttaaa atcctgggag atgtatttgg gtttagcgtg gtcgtatgtt     2280

gtctactata gtccaagtga agttcgagtg gtggcagaag gatttgattt tgctaatgga     2340

atcaacattt cacccgatgg caagtatgtc tatatagctg agttgctggc tcataagatt     2400

catgtgtatg aaaagcatgc taattggact ttaactccat tgaagtccct tgactttaat     2460

accctcgtgg ataacatatc tgtggatcct gagacaggag acctttgggt tggatgccat     2520

cccaatggca tgaaaatctt cttctatgac tcagagaatc ctcctgcatc agaggtgctt     2580

cgaatccaga acattctaac agaagaacct aaagtgacac aggtttatgc agaaaatggc     2640

acagtgttgc aaggcagtac agttgcctct gtgtacaaag ggaaactgct gattggcaca     2700

gtgtttcaca aagctcttta ctgtgagctc taataatcta gaa                       2743


<210>  60
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R]-(g4s)6-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K]

<400>  60

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser 
545                 550                 555                 560 


Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser Tyr Gln 
                565                 570                 575     


Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu Pro Asn 
            580                 585                 590         


Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile 
        595                 600                 605             


Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly 
    610                 615                 620                 


Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu Met Asp 
625                 630                 635                 640 


Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr Gly Ser 
                645                 650                 655     


Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr 
            660                 665                 670         


Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His Pro Asp Ala 
        675                 680                 685             


Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu 
    690                 695                 700                 


Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu Asn Asp 
705                 710                 715                 720 


Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp His Tyr 
                725                 730                 735     


Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala 
            740                 745                 750         


Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val Val Ala 
        755                 760                 765             


Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys 
    770                 775                 780                 


Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His Val Tyr Glu 
785                 790                 795                 800 


Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn 
                805                 810                 815     


Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp Leu Trp 
            820                 825                 830         


Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu 
        835                 840                 845             


Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu Thr Glu 
    850                 855                 860                 


Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val Leu Gln 
865                 870                 875                 880 


Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr 
                885                 890                 895     


Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
            900                 905     


<210>  61
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[KDL-SCChinge-P238S-P331S Fc]-NGS-[PON1 Q192K]

<400>  61

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Asp Leu Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val 
                245                 250                 255     


Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp 
            260                 265                 270         


Ile Leu Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala 
        275                 280                 285             


Leu Arg Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys 
    290                 295                 300                 


Gly Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu 
305                 310                 315                 320 


Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn 
                325                 330                 335     


Pro Asn Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp 
            340                 345                 350         


Pro Thr Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser 
        355                 360                 365             


Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala 
    370                 375                 380                 


Met Tyr Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu 
385                 390                 395                 400 


Leu Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr 
                405                 410                 415     


Ile Arg His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly 
            420                 425                 430         


Pro Glu His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr 
        435                 440                 445             


Leu Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val 
    450                 455                 460                 


Tyr Tyr Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe 
465                 470                 475                 480 


Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala 
                485                 490                 495     


Glu Leu Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp 
            500                 505                 510         


Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn 
        515                 520                 525             


Ile Ser Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro 
    530                 535                 540                 


Asn Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser 
545                 550                 555                 560 


Glu Val Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr 
                565                 570                 575     


Gln Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala 
            580                 585                 590         


Ser Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala 
        595                 600                 605             


Leu Tyr Cys Glu Leu 
    610             


<210>  62
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[KDL-SCChinge-P238S-P331S Fc]-NGS-[G3C9 PON1]

<400>  62

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Asp Leu Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val 
                245                 250                 255     


Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp 
            260                 265                 270         


Ile Leu Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val 
        275                 280                 285             


His Arg Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys 
    290                 295                 300                 


Gly Val Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu 
305                 310                 315                 320 


Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp 
                325                 330                 335     


Pro Asp Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp 
            340                 345                 350         


Pro Val Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser 
        355                 360                 365             


Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr 
    370                 375                 380                 


Val Tyr Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu 
385                 390                 395                 400 


Val Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr 
                405                 410                 415     


Ile Arg His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly 
            420                 425                 430         


Pro Glu His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr 
        435                 440                 445             


Leu Lys Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr 
    450                 455                 460                 


Tyr Tyr Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe 
465                 470                 475                 480 


Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala 
                485                 490                 495     


Glu Leu Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp 
            500                 505                 510         


Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn 
        515                 520                 525             


Ile Ser Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro 
    530                 535                 540                 


Asn Gly Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser 
545                 550                 555                 560 


Glu Val Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr 
                565                 570                 575     


Val Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala 
            580                 585                 590         


Ala Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala 
        595                 600                 605             


Leu Tyr Cys Glu Leu 
    610             


<210>  63
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[KDL-SCChinge-P238S-P331S Fc]-NGS-[M-IIG1 PON1]

<400>  63

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Asp Leu Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val 
                245                 250                 255     


Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp 
            260                 265                 270         


Ile Leu Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val 
        275                 280                 285             


His Arg Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys 
    290                 295                 300                 


Gly Val Asp Asn Gly Ser Glu Asp Ile Glu Ile Leu Pro Asn Gly Leu 
305                 310                 315                 320 


Ala Phe Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp 
                325                 330                 335     


Pro Asp Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp 
            340                 345                 350         


Pro Val Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser 
        355                 360                 365             


Ser Phe Asn Pro Ala Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr 
    370                 375                 380                 


Val Tyr Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu 
385                 390                 395                 400 


Val Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr 
                405                 410                 415     


Ile Arg His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly 
            420                 425                 430         


Pro Glu His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr 
        435                 440                 445             


Leu Lys Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr 
    450                 455                 460                 


Tyr Tyr Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met 
465                 470                 475                 480 


Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala 
                485                 490                 495     


Glu Leu Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp 
            500                 505                 510         


Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn 
        515                 520                 525             


Ile Ser Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro 
    530                 535                 540                 


Asn Gly Met Arg Leu Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser 
545                 550                 555                 560 


Glu Val Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr 
                565                 570                 575     


Val Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala 
            580                 585                 590         


Ala Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala 
        595                 600                 605             


Leu Tyr Cys Glu Leu 
    610             


<210>  64
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[SCChinge-P238S-P331S Fc]-NGS-[PON1 Q192K]

<400>  64

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala 
                245                 250                 255     


Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe 
            260                 265                 270         


Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu 
        275                 280                 285             


Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile Glu 
    290                 295                 300                 


Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile 
305                 310                 315                 320 


Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser 
                325                 330                 335     


Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr Val 
            340                 345                 350         


Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe Asn 
        355                 360                 365             


Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu 
    370                 375                 380                 


Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe Lys 
385                 390                 395                 400 


Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His 
                405                 410                 415     


Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu His 
            420                 425                 430         


Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser 
        435                 440                 445             


Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser 
    450                 455                 460                 


Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly 
465                 470                 475                 480 


Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu 
                485                 490                 495     


Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr 
            500                 505                 510         


Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser Val 
        515                 520                 525             


Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met 
    530                 535                 540                 


Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val Leu 
545                 550                 555                 560 


Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val Tyr 
                565                 570                 575     


Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val Tyr 
            580                 585                 590         


Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys 
        595                 600                 605             


Glu Leu 
    610 


<210>  65
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[SCChinge-P238S-P331S Fc]-NGS-[G3C9 PON1]

<400>  65

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala 
                245                 250                 255     


Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe 
            260                 265                 270         


Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg Glu 
        275                 280                 285             


Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val Asp 
    290                 295                 300                 


Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile 
305                 310                 315                 320 


Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp Lys 
                325                 330                 335     


Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val Val 
            340                 345                 350         


Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe Asn 
        355                 360                 365             


Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr Leu 
    370                 375                 380                 


Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe Lys 
385                 390                 395                 400 


Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His 
                405                 410                 415     


Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu His 
            420                 425                 430         


Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys Ser 
        435                 440                 445             


Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr Ser 
    450                 455                 460                 


Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly 
465                 470                 475                 480 


Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu 
                485                 490                 495     


Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr 
            500                 505                 510         


Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser Val 
        515                 520                 525             


Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met 
    530                 535                 540                 


Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val Leu 
545                 550                 555                 560 


Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val Tyr 
                565                 570                 575     


Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val Tyr 
            580                 585                 590         


Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys 
        595                 600                 605             


Glu Leu 
    610 


<210>  66
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[SCChinge-P238S-P331S Fc]-NGS-[M-IIG1 PON1]

<400>  66

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala 
                245                 250                 255     


Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe 
            260                 265                 270         


Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg Glu 
        275                 280                 285             


Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val Asp 
    290                 295                 300                 


Asn Gly Ser Glu Asp Ile Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile 
305                 310                 315                 320 


Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp Lys 
                325                 330                 335     


Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val Val 
            340                 345                 350         


Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe Asn 
        355                 360                 365             


Pro Ala Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr Leu 
    370                 375                 380                 


Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe Lys 
385                 390                 395                 400 


Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His 
                405                 410                 415     


Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu His 
            420                 425                 430         


Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys Ser 
        435                 440                 445             


Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr Ser 
    450                 455                 460                 


Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn Gly 
465                 470                 475                 480 


Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu 
                485                 490                 495     


Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr 
            500                 505                 510         


Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser Val 
        515                 520                 525             


Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met 
    530                 535                 540                 


Arg Leu Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val Leu 
545                 550                 555                 560 


Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val Tyr 
                565                 570                 575     


Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val Tyr 
            580                 585                 590         


Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys 
        595                 600                 605             


Glu Leu 
    610 


<210>  67
<211>  2721
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 R80A-R95A-N96A 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc]-NGS-[PON1 Q192K] DNA

<400>  67
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

atgaggatct gctccttcaa cgtcaggtcc tttggggaaa gcaagcagga agacaagaat      120

gccatggatg tcattgtgaa ggtcatcaaa cgctgtgaca tcatactcgt gatggaaatc      180

aaggacagca acaacaggat ctgccccata ctgatggaga agctgaacag aaattcagca      240

agaggcataa cgtacaacta tgtgattagc tctcggcttg gagcagctac atataaagaa      300

caatatgcct ttctctacaa ggaaaagctg gtgtctgtga agaggagtta tcactaccat      360

gactatcagg atggagacgc agatgtgttt tccagggagc cctttgtggt ctggttccaa      420

tctccccaca ctgctgtcaa agacttcgtg attatccccc tgcacaccac cccagagaca      480

tccgttaagg agatcgatga gttggttgag gtctacacgg acgtgaaaca ccgctggaag      540

gcggagaatt tcattttcat gggtgacttc aatgccggct gcagctacgt ccccaagaag      600

gcctggaaga acatccgctt gaggactgac cccaggtttg tttggctgat cggggaccaa      660

gaggacacca cggtgaagaa gagcaccaac tgtgcatatg acaggattgt gcttagagga      720

caagaaatcg tcagttctgt tgttcccaag tcaaacagtg tttttgactt ccagaaagct      780

tacaagctga ctgaagagga ggccctggat gtcagcgacc actttccagt tgaatttaaa      840

ctacagtctt caagggcctt caccaactca gatctctccg gaggaggtgg ctcaggtggt      900

ggaggatctg gaggaggtgg gagtggtgga ggtggttcta ccggtctcga gcccaaatct      960

tctgacaaaa ctcacacatc tccaccgtcc ccagcacctg aactcctggg aggatcgtca     1020

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1080

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1140

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1200

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1260

aagtgcaagg tctccaacaa agccctccca gcctccatcg agaaaaccat ctccaaagcc     1320

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1380

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1440

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1500

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1560

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1620

agcctctctc tctctccggg taaagtcgac ggagctagca gccccgtgaa cgtgagcagc     1680

cccagcgtgc aggatatcct cttcaggaac caccagtctt cttaccaaac acgacttaat     1740

gctctccgag aggtacaacc cgtagaactt cctaactgta atttagttaa aggaatcgaa     1800

actggctctg aagacttgga gatactgcct aatggactgg ctttcattag ctctggatta     1860

aagtatcctg gaataaagag cttcaacccc aacagtcctg gaaaaatact tctgatggac     1920

ctgaatgaag aagatccaac agtgttggaa ttggggatca ctggaagtaa atttgatgta     1980

tcttcattta accctcatgg gattagcaca ttcacagatg aagataatgc catgtacctc     2040

ctggtggtga accatccaga tgccaagtcc acagtggagt tgtttaaatt tcaagaagaa     2100

gaaaaatcgc ttttgcatct aaaaaccatc agacataaac ttctgcctaa tttgaatgat     2160

attgttgctg tgggacctga gcacttttat ggcacaaatg atcactattt tcttgacccc     2220

tacttaaaat cctgggagat gtatttgggt ttagcgtggt cgtatgttgt ctactatagt     2280

ccaagtgaag ttcgagtggt ggcagaagga tttgattttg ctaatggaat caacatttca     2340

cccgatggca agtatgtcta tatagctgag ttgctggctc ataagattca tgtgtatgaa     2400

aagcatgcta attggacttt aactccattg aagtcccttg actttaatac cctcgtggat     2460

aacatatctg tggatcctga gacaggagac ctttgggttg gatgccatcc caatggcatg     2520

aaaatcttct tctatgactc agagaatcct cctgcatcag aggtgcttcg aatccagaac     2580

attctaacag aagaacctaa agtgacacag gtttatgcag aaaatggcac agtgttgcaa     2640

ggcagtacag ttgcctctgt gtacaaaggg aaactgctga ttggcacagt gtttcacaaa     2700

gctctttact gtgagctcta a                                               2721


<210>  68
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 R80A-R95A-N96A 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc]-NGS-[PON1 Q192K]

<400>  68

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Ala 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Ala Ala 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser 
545                 550                 555                 560 


Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser Tyr Gln 
                565                 570                 575     


Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu Pro Asn 
            580                 585                 590         


Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile 
        595                 600                 605             


Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly 
    610                 615                 620                 


Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu Met Asp 
625                 630                 635                 640 


Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr Gly Ser 
                645                 650                 655     


Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr 
            660                 665                 670         


Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His Pro Asp Ala 
        675                 680                 685             


Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu 
    690                 695                 700                 


Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu Asn Asp 
705                 710                 715                 720 


Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp His Tyr 
                725                 730                 735     


Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala 
            740                 745                 750         


Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val Val Ala 
        755                 760                 765             


Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys 
    770                 775                 780                 


Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His Val Tyr Glu 
785                 790                 795                 800 


Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn 
                805                 810                 815     


Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp Leu Trp 
            820                 825                 830         


Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu 
        835                 840                 845             


Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu Thr Glu 
    850                 855                 860                 


Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val Leu Gln 
865                 870                 875                 880 


Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr 
                885                 890                 895     


Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
            900                 905     


<210>  69
<211>  2721
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 R80S-R95S-N96S 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc]-NGS-[PON1 Q192K] DNA

<400>  69
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

atgaggatct gctccttcaa cgtcaggtcc tttggggaaa gcaagcagga agacaagaat      120

gccatggatg tcattgtgaa ggtcatcaaa cgctgtgaca tcatactcgt gatggaaatc      180

aaggacagca acaacaggat ctgccccata ctgatggaga agctgaacag aaattcatca      240

agaggcataa cgtacaacta tgtgattagc tctcggcttg gaagttctac atataaagaa      300

caatatgcct ttctctacaa ggaaaagctg gtgtctgtga agaggagtta tcactaccat      360

gactatcagg atggagacgc agatgtgttt tccagggagc cctttgtggt ctggttccaa      420

tctccccaca ctgctgtcaa agacttcgtg attatccccc tgcacaccac cccagagaca      480

tccgttaagg agatcgatga gttggttgag gtctacacgg acgtgaaaca ccgctggaag      540

gcggagaatt tcattttcat gggtgacttc aatgccggct gcagctacgt ccccaagaag      600

gcctggaaga acatccgctt gaggactgac cccaggtttg tttggctgat cggggaccaa      660

gaggacacca cggtgaagaa gagcaccaac tgtgcatatg acaggattgt gcttagagga      720

caagaaatcg tcagttctgt tgttcccaag tcaaacagtg tttttgactt ccagaaagct      780

tacaagctga ctgaagagga ggccctggat gtcagcgacc actttccagt tgaatttaaa      840

ctacagtctt caagggcctt caccaactca gatctctccg gaggaggtgg ctcaggtggt      900

ggaggatctg gaggaggtgg gagtggtgga ggtggttcta ccggtctcga gcccaaatct      960

tctgacaaaa ctcacacatc tccaccgtcc ccagcacctg aactcctggg aggatcgtca     1020

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1080

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1140

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1200

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1260

aagtgcaagg tctccaacaa agccctccca gcctccatcg agaaaaccat ctccaaagcc     1320

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1380

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1440

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1500

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1560

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1620

agcctctctc tctctccggg taaagtcgac ggagctagca gccccgtgaa cgtgagcagc     1680

cccagcgtgc aggatatcct cttcaggaac caccagtctt cttaccaaac acgacttaat     1740

gctctccgag aggtacaacc cgtagaactt cctaactgta atttagttaa aggaatcgaa     1800

actggctctg aagacttgga gatactgcct aatggactgg ctttcattag ctctggatta     1860

aagtatcctg gaataaagag cttcaacccc aacagtcctg gaaaaatact tctgatggac     1920

ctgaatgaag aagatccaac agtgttggaa ttggggatca ctggaagtaa atttgatgta     1980

tcttcattta accctcatgg gattagcaca ttcacagatg aagataatgc catgtacctc     2040

ctggtggtga accatccaga tgccaagtcc acagtggagt tgtttaaatt tcaagaagaa     2100

gaaaaatcgc ttttgcatct aaaaaccatc agacataaac ttctgcctaa tttgaatgat     2160

attgttgctg tgggacctga gcacttttat ggcacaaatg atcactattt tcttgacccc     2220

tacttaaaat cctgggagat gtatttgggt ttagcgtggt cgtatgttgt ctactatagt     2280

ccaagtgaag ttcgagtggt ggcagaagga tttgattttg ctaatggaat caacatttca     2340

cccgatggca agtatgtcta tatagctgag ttgctggctc ataagattca tgtgtatgaa     2400

aagcatgcta attggacttt aactccattg aagtcccttg actttaatac cctcgtggat     2460

aacatatctg tggatcctga gacaggagac ctttgggttg gatgccatcc caatggcatg     2520

aaaatcttct tctatgactc agagaatcct cctgcatcag aggtgcttcg aatccagaac     2580

attctaacag aagaacctaa agtgacacag gtttatgcag aaaatggcac agtgttgcaa     2640

ggcagtacag ttgcctctgt gtacaaaggg aaactgctga ttggcacagt gtttcacaaa     2700

gctctttact gtgagctcta a                                               2721


<210>  70
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 R80S-R95S-N96S 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc]-NGS-[PON1 Q192K]

<400>  70

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Ser 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Ser Ser 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser 
545                 550                 555                 560 


Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser Tyr Gln 
                565                 570                 575     


Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu Pro Asn 
            580                 585                 590         


Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile 
        595                 600                 605             


Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly 
    610                 615                 620                 


Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu Met Asp 
625                 630                 635                 640 


Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr Gly Ser 
                645                 650                 655     


Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr 
            660                 665                 670         


Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His Pro Asp Ala 
        675                 680                 685             


Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu 
    690                 695                 700                 


Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu Asn Asp 
705                 710                 715                 720 


Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp His Tyr 
                725                 730                 735     


Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala 
            740                 745                 750         


Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val Val Ala 
        755                 760                 765             


Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys 
    770                 775                 780                 


Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His Val Tyr Glu 
785                 790                 795                 800 


Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn 
                805                 810                 815     


Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp Leu Trp 
            820                 825                 830         


Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu 
        835                 840                 845             


Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu Thr Glu 
    850                 855                 860                 


Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val Leu Gln 
865                 870                 875                 880 


Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr 
                885                 890                 895     


Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
            900                 905     


