                         SEQUENCE LISTING

<110>  Rijksuniversiteit Groningen
       Academisch Ziekenhuis Groningen
 
<120>  Synthetic peptides blocking SARS-CoV-2 (COVID-19), and 
       compositions, methods and uses related thereto

<130>  P129461PC00

<140>  PCT/NL2022/050112
<141>  2022-02-25

<150>  EP 21159540.0
<151>  2021-02-26

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide A1

<400>  1

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Gln His Glu Val 
1               5                   10                  15      


Glu Glu Ile Tyr Trp Gln Ser 
            20              


<210>  2
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide A2

<400>  2

Gln Asp Lys His Glu Glu Asp Tyr Gln Met Tyr Asn Lys Gly Asp Lys 
1               5                   10                  15      


Glu Asp 
        


<210>  3
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide A3

<400>  3

Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu 
1               5                   10                  15      


Ala Ser Trp Asn Tyr Asn Thr 
            20              


<210>  4
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide A4

<400>  4

Ile Asp Glu Asn Ala Arg Ser Tyr Ile Asp Lys Phe Gln His Asp Ala 
1               5                   10                  15      


Glu Glu Met Trp Tyr Gln 
            20          


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide A5

<400>  5

Ile Tyr Ala Leu Leu Glu Asn Ala Glu Asp Tyr Asn Leu Val Asn 
1               5                   10                  15  


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide A6

<400>  6

Ser Arg Asp Lys His Glu Glu His Glu Lys Glu Asn Asp Arg Gly Gln 
1               5                   10                  15      


<210>  7
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 1


<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  AMIDATION

<400>  7

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Gln His Glu Val 
1               5                   10                  15      


Glu Glu Ile Tyr Trp Gln Ser 
            20              


<210>  8
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 2


<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  8

Gln Asp Lys His Glu Glu Asp Tyr Gln Met Tyr Asn Lys Gly Asp Lys 
1               5                   10                  15      


Glu Asp 
        


<210>  9
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 3


<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  AMIDATION

<400>  9

Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu 
1               5                   10                  15      


Ala Ser Trp Asn Tyr Asn Thr 
            20              


<210>  10
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 4


<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  10

Ile Asp Glu Asn Ala Arg Ser Tyr Ile Asp Lys Phe Gln His Asp Ala 
1               5                   10                  15      


Glu Glu Met Trp Tyr Gln 
            20          


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 5


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  11

Ile Tyr Ala Leu Leu Glu Asn Ala Glu Asp Tyr Asn Leu Val Asn 
1               5                   10                  15  


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 6


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  12

Ser Arg Asp Lys His Glu Glu His Glu Lys Glu Asn Asp Arg Gly Gln 
1               5                   10                  15      


<210>  13
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  13

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser 
            20              


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  14

Thr Phe Leu Asp Lys Phe Asn His Glu Ala Glu Asp 
1               5                   10          


<210>  15
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  inhibitor 1

<400>  15

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Ala Glu 
1               5                   10                  15      


Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr Asn 
            20                  25                  30          


Ile Thr 
        


<210>  16
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  inhibitor 2 (1)

<400>  16

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile 
65              


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  inhibitor 2 (2)

<400>  17

Trp Asp Leu Gly Lys Gly Asp Phe Arg 
1               5                   


<210>  18
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  inhibitor 3 (1)

<400>  18

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Ala Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
65                  70                  75                  80  


Gln Gln Asn Gly Ser 
                85  


<210>  19
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  inhibitor 3 (2)

<400>  19

Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
1               5                   10                  15      


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
            20                  25                  30          


Asp Phe Arg Ile Leu Met Cys Thr 
        35                  40  


<210>  20
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  inhibitor 4 (1)

<400>  20

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
            20                  25                  30          


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
        35                  40                  45              


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
    50                  55                  60                  


Leu Gln Glu Ile Gln Ala Leu Thr Val Lys Leu 
65                  70                  75  


<210>  21
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  inhibitor 4 (2)

<400>  21

Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp 
1               5                   10                  15      


Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met 
            20                  25                  30          


Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp 
        35                  40                  45              


Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu 
    50                  55                  60                  


Gly Phe 
65      


<210>  22
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  22

Ser Leu Asp Gln Ile Asn Val Thr Phe Leu Asp Leu Glu Tyr Glu Met 
1               5                   10                  15      


Lys Lys Leu Glu Glu Ala Ile Lys Lys Leu Glu Glu Ser Tyr Ile Asp 
            20                  25                  30          


Leu Lys Glu Leu 
        35      


<210>  23
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  23

Thr Trp Leu Ala Thr Arg Gly Leu Leu Arg Ser Pro Gly Arg Tyr Val 
1               5                   10                  15      


Tyr Phe Ser Pro Ser Ala Ser Thr Trp Pro Val Gly Ile Trp Thr Thr 
            20                  25                  30          


Gly Glu Leu Val Leu Gly Cys Asp Ala Ala Leu 
        35                  40              


<210>  24
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  24

Gly Cys Ala Ser Arg Cys Lys Ala Lys Cys Ala Gly Arg Arg Cys Lys 
1               5                   10                  15      


Gly Trp Ala Ser Ala Phe Arg Gly Arg Cys Tyr Cys Lys Cys Phe Arg 
            20                  25                  30          


Cys 
    


<210>  25
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  25

Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile Glu Asp Leu 
1               5                   10                  15      


Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met Lys Gln Tyr 
            20                  25                  30          


Gly 
    


<210>  26
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  26

Ala Ser Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly 
1               5                   10                  15      


Gln Ser Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His 
            20                  25                  


<210>  27
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  27

Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
1               5                   10                  15      


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            20                  25                  30          


<210>  28
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  28

Ala Ser Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly 
1               5                   10                  15      


Gln Ser Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr 
            20                  25              


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  29

Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1               5                   10              


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  30

Leu Leu Phe Asn Lys Val Leu Thr Ala 
1               5                   


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  31

Leu Ala Lys Ile Leu Lys Glu Lys Tyr Gly Leu Asp 
1               5                   10          


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  32

Glu Ile Leu Asp Lys Ser Lys Glu Lys Thr Ser Phe Asp 
1               5                   10              


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  33

Leu Lys Glu Ser Lys Asp Leu Val 
1               5               


<210>  34
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  34

Val Pro Lys His Leu Lys Lys Gly Leu Ser Lys Glu Glu Ala Glu Ser 
1               5                   10                  15      


Leu Lys Lys Gln Leu Glu Glu Val 
            20                  


<210>  35
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  35

Asn Gly Ala Ile Cys Trp Gly Pro Cys Pro Thr Ala Phe Arg Gln Ile 
1               5                   10                  15      


Gly Asn Cys Gly His Phe Lys Val Arg Cys Cys Lys Ile Arg 
            20                  25                  30  


<210>  36
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  36

Asn Gly Ala Ile Cys Trp Gly Pro Cys Pro Thr Ala Phe Arg Gln Ile 
1               5                   10                  15      


Gly Asn Cys Gly Arg Phe Arg Val Arg Cys Cys Arg Ile Arg 
            20                  25                  30  


<210>  37
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  37

Asn Gly Ala Ile Cys Trp Gly Pro Cys Pro Thr Ala Phe Arg Gln Ile 
1               5                   10                  15      


Gly Asn Cys Gly His Phe Lys Val Arg Cys Cys Lys Ile Arg Asp Glu 
            20                  25                  30          


Asp 
    


<210>  38
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  38

Asn Gly Ala His Ser Trp His Pro Asn Glu Thr His Phe Arg Gln Ile 
1               5                   10                  15      


His Asn Ser Gly Arg His Arg Val Arg Ser His Arg Ile Arg 
            20                  25                  30  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide

<400>  39

Phe Leu Lys Asp Glu Asn His Glu Ala Glu Asp Leu Leu Asp Lys 
1               5                   10                  15  


