                         SEQUENCE LISTING

<110>  LYELL IMMUNOPHARMA, INC.
 
<120>  ROR1 TARGETING CHIMERIC ANTIGEN RECEPTOR

<130>  4385.042PC04

<150>  US 63/153,878
<151>  2021-02-25

<150>  US 63/263,229
<151>  2021-10-28

<150>  US 63/309,393
<151>  2022-02-11

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  331
<212>  PRT
<213>  artificial sequence

<220>
<223>  wild type human c-Jun protein

<400>  1

Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
1               5                   10                  15      


Ser Phe Leu Pro Ser Glu Ser Gly Pro Tyr Gly Tyr Ser Asn Pro Lys 
            20                  25                  30          


Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser 
        35                  40                  45              


Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
    50                  55                  60                  


Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
65                  70                  75                  80  


Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                85                  90                  95      


Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
            100                 105                 110         


Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
        115                 120                 125             


Ser Val Thr Ser Ala Ala Gln Pro Val Asn Gly Ala Gly Met Val Ala 
    130                 135                 140                 


Pro Ala Val Ala Ser Val Ala Gly Gly Ser Gly Ser Gly Gly Phe Ser 
145                 150                 155                 160 


Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                165                 170                 175     


Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
            180                 185                 190         


Ala Gly Leu Ala Phe Pro Ala Gln Pro Gln Gln Gln Gln Gln Pro Pro 
        195                 200                 205             


His His Leu Pro Gln Gln Met Pro Val Gln His Pro Arg Leu Gln Ala 
    210                 215                 220                 


Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly Glu Thr Pro 
225                 230                 235                 240 


Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile Lys Ala Glu 
                245                 250                 255     


Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg 
            260                 265                 270         


Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys 
        275                 280                 285             


Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln 
    290                 295                 300                 


Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn Ser Gly Cys 
305                 310                 315                 320 


Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe 
                325                 330     


<210>  2
<211>  3257
<212>  DNA
<213>  artificial sequence

<220>
<223>  wild type human c-Jun gene

<400>  2
gctcagagtt gcactgagtg tggctgaagc agcgaggcgg gagtggaggt gcgcggagtc       60

aggcagacag acagacacag ccagccagcc aggtcggcag tatagtccga actgcaaatc      120

ttattttctt ttcaccttct ctctaactgc ccagagctag cgcctgtggc tcccgggctg      180

gtgtttcggg agtgtccaga gagcctggtc tccagccgcc cccgggagga gagccctgct      240

gcccaggcgc tgttgacagc ggcggaaagc agcggtaccc acgcgcccgc cgggggaagt      300

cggcgagcgg ctgcagcagc aaagaacttt cccggctggg aggaccggag acaagtggca      360

gagtcccgga gccaactttt gcaagccttt cctgcgtctt aggcttctcc acggcggtaa      420

agaccagaag gcggcggaga gccacgcaag agaagaagga cgtgcgctca gcttcgctcg      480

caccggttgt tgaacttggg cgagcgcgag ccgcggctgc cgggcgcccc ctccccctag      540

cagcggagga ggggacaagt cgtcggagtc cgggcggcca agacccgccg ccggccggcc      600

actgcagggt ccgcactgat ccgctccgcg gggagagccg ctgctctggg aagtgagttc      660

gcctgcggac tccgaggaac cgctgcgcac gaagagcgct cagtgagtga ccgcgacttt      720

tcaaagccgg gtagcgcgcg cgagtcgaca agtaagagtg cgggaggcat cttaattaac      780

cctgcgctcc ctggagcgag ctggtgagga gggcgcagcg gggacgacag ccagcgggtg      840

cgtgcgctct tagagaaact ttccctgtca aaggctccgg ggggcgcggg tgtcccccgc      900

ttgccacagc cctgttgcgg ccccgaaact tgtgcgcgca gcccaaacta acctcacgtg      960

aagtgacgga ctgttctatg actgcaaaga tggaaacgac cttctatgac gatgccctca     1020

acgcctcgtt cctcccgtcc gagagcggac cttatggcta cagtaacccc aagatcctga     1080

aacagagcat gaccctgaac ctggccgacc cagtggggag cctgaagccg cacctccgcg     1140

ccaagaactc ggacctcctc acctcgcccg acgtggggct gctcaagctg gcgtcgcccg     1200

agctggagcg cctgataatc cagtccagca acgggcacat caccaccacg ccgaccccca     1260

cccagttcct gtgccccaag aacgtgacag atgagcagga gggcttcgcc gagggcttcg     1320

tgcgcgccct ggccgaactg cacagccaga acacgctgcc cagcgtcacg tcggcggcgc     1380

agccggtcaa cggggcaggc atggtggctc ccgcggtagc ctcggtggca gggggcagcg     1440

gcagcggcgg cttcagcgcc agcctgcaca gcgagccgcc ggtctacgca aacctcagca     1500

acttcaaccc aggcgcgctg agcagcggcg gcggggcgcc ctcctacggc gcggccggcc     1560

tggcctttcc cgcgcaaccc cagcagcagc agcagccgcc gcaccacctg ccccagcaga     1620

tgcccgtgca gcacccgcgg ctgcaggccc tgaaggagga gcctcagaca gtgcccgaga     1680

tgcccggcga gacaccgccc ctgtccccca tcgacatgga gtcccaggag cggatcaagg     1740

cggagaggaa gcgcatgagg aaccgcatcg ctgcctccaa gtgccgaaaa aggaagctgg     1800

agagaatcgc ccggctggag gaaaaagtga aaaccttgaa agctcagaac tcggagctgg     1860

cgtccacggc caacatgctc agggaacagg tggcacagct taaacagaaa gtcatgaacc     1920

acgttaacag tgggtgccaa ctcatgctaa cgcagcagtt gcaaacattt tgaagagaga     1980

ccgtcggggg ctgaggggca acgaagaaaa aaaataacac agagagacag acttgagaac     2040

ttgacaagtt gcgacggaga gaaaaaagaa gtgtccgaga actaaagcca agggtatcca     2100

agttggactg ggttgcgtcc tgacggcgcc cccagtgtgc acgagtggga aggacttggc     2160

gcgccctccc ttggcgtgga gccagggagc ggccgcctgc gggctgcccc gctttgcgga     2220

cgggctgtcc ccgcgcgaac ggaacgttgg acttttcgtt aacattgacc aagaactgca     2280

tggacctaac attcgatctc attcagtatt aaagggggga gggggagggg gttacaaact     2340

gcaatagaga ctgtagattg cttctgtagt actccttaag aacacaaagc ggggggaggg     2400

ttggggaggg gcggcaggag ggaggtttgt gagagcgagg ctgagcctac agatgaactc     2460

tttctggcct gccttcgtta actgtgtatg tacatatata tattttttaa tttgatgaaa     2520

gctgattact gtcaataaac agcttcatgc ctttgtaagt tatttcttgt ttgtttgttt     2580

gggtatcctg cccagtgttg tttgtaaata agagatttgg agcactctga gtttaccatt     2640

tgtaataaag tatataattt ttttatgttt tgtttctgaa aattccagaa aggatattta     2700

agaaaataca ataaactatt ggaaagtact cccctaacct cttttctgca tcatctgtag     2760

atactagcta tctaggtgga gttgaaagag ttaagaatgt cgattaaaat cactctcagt     2820

gcttcttact attaagcagt aaaaactgtt ctctattaga ctttagaaat aaatgtacct     2880

gatgtacctg atgctatggt caggttatac tcctcctccc ccagctatct atatggaatt     2940

gcttaccaaa ggatagtgcg atgtttcagg aggctggagg aaggggggtt gcagtggaga     3000

gggacagccc actgagaagt caaacatttc aaagtttgga ttgtatcaag tggcatgtgc     3060

tgtgaccatt tataatgtta gtagaaattt tacaataggt gcttattctc aaagcaggaa     3120

ttggtggcag attttacaaa agatgtatcc ttccaatttg gaatcttctc tttgacaatt     3180

cctagataaa aagatggcct ttgcttatga atatttataa cagcattctt gtcacaataa     3240

atgtattcaa ataccaa                                                    3257


<210>  3
<211>  338
<212>  PRT
<213>  artificial sequence

<220>
<223>  epidermal growth factor receptor protein opt (EGFRopt)

<400>  3

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg 
                325                 330                 335     


Arg Arg 
        


<210>  4

<400>  4
000

<210>  5
<211>  353
<212>  PRT
<213>  artificial sequence

<220>
<223>  Uniprot: P01876, IGHA1_HUMAN, immunoglobulin heavy constant alpha
       1

<400>  5

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210>  6
<211>  340
<212>  PRT
<213>  artificial sequence

<220>
<223>  Uniprot P01877, IGHA2_HUMAN, immunoglobulin heavy constant alpha 
       2

<400>  6

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Ser Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Tyr Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Glu Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Met Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Ile Asn Val Ser Val Val Met Ala Glu Ala Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210>  7
<211>  398
<212>  PRT
<213>  artificial sequence

<220>
<223>  Uniprot P01665, GCAM_MOUSE, immunoglobulin gamma 2A chain C 
       region

<400>  7

Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp 
1               5                   10                  15      


Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly 
        35                  40                  45              


Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser 
    50                  55                  60                  


Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr 
65                  70                  75                  80  


Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile 
                85                  90                  95      


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
            100                 105                 110         


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
        115                 120                 125             


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
    130                 135                 140                 


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
145                 150                 155                 160 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
                165                 170                 175     


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
            180                 185                 190         


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
        195                 200                 205             


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
    210                 215                 220                 


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
225                 230                 235                 240 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
                245                 250                 255     


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
            260                 265                 270         


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
        275                 280                 285             


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
    290                 295                 300                 


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
305                 310                 315                 320 


Lys Ser Phe Ser Arg Thr Pro Gly Leu Asp Leu Asp Asp Val Cys Ala 
                325                 330                 335     


Glu Ala Gln Asp Gly Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr Ile 
            340                 345                 350         


Phe Ile Ser Leu Phe Leu Leu Ser Val Cys Tyr Ser Ala Ser Val Thr 
        355                 360                 365             


Leu Phe Lys Val Lys Trp Ile Phe Ser Ser Val Val Glu Leu Lys Gln 
    370                 375                 380                 


Thr Ile Ser Pro Asp Tyr Arg Asn Met Ile Gly Gln Gly Ala 
385                 390                 395             


<210>  8
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  Uniprot P01857, IGHG1_HUMAN, immunoglobulin heavy constant gamma 
       1

<400>  8

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  9
<211>  326
<212>  PRT
<213>  artificial sequence

<220>
<223>  Uniprot P01859, IGHG2_HUMAN, immunoglobulin heavy constant gamma 
       2

<400>  9

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  10
<211>  377
<212>  PRT
<213>  artificial sequence

<220>
<223>  Uniprot P01860, IGHG3_HUMAN, immunoglobulin heavy constant gamma 
       3

<400>  10

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  11
<211>  327
<212>  PRT
<213>  artificial sequence

<220>
<223>  Uniprot P01861, IGHG4, immunoglobulin heavy constant gamma 4

<400>  11

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  12
<211>  384
<212>  PRT
<213>  artificial sequence

<220>
<223>  Uniprot P01880, IGHD_HUMAN, immunoglobulin heavy constant delta

<400>  12

Ala Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg 
1               5                   10                  15      


His Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly 
            20                  25                  30          


Tyr His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser 
        35                  40                  45              


Gln Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr 
    50                  55                  60                  


Met Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly 
65                  70                  75                  80  


Glu Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu 
                85                  90                  95      


Ile Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro 
            100                 105                 110         


Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala 
        115                 120                 125             


Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys 
    130                 135                 140                 


Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu 
145                 150                 155                 160 


Cys Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala 
                165                 170                 175     


Val Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val 
            180                 185                 190         


Val Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly 
        195                 200                 205             


Lys Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser 
    210                 215                 220                 


Asn Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu 
225                 230                 235                 240 


Trp Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu 
                245                 250                 255     


Pro Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro 
            260                 265                 270         


Val Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala 
        275                 280                 285             


Ala Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile 
    290                 295                 300                 


Leu Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe 
305                 310                 315                 320 


Ala Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser Thr Thr Phe Trp Ala 
                325                 330                 335     


Trp Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr 
            340                 345                 350         


Tyr Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala 
        355                 360                 365             


Ser Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys 
    370                 375                 380                 


<210>  13
<211>  428
<212>  PRT
<213>  artificial sequence

<220>
<223>  Uniprot P01854, IGHE_HUMAN, immunoglobulin heavy constant chain 
       epsilon

<400>  13

Ala Ser Thr Gln Ser Pro Ser Val Phe Pro Leu Thr Arg Cys Cys Lys 
1               5                   10                  15      


Asn Ile Pro Ser Asn Ala Thr Ser Val Thr Leu Gly Cys Leu Ala Thr 
            20                  25                  30          


Gly Tyr Phe Pro Glu Pro Val Met Val Thr Trp Asp Thr Gly Ser Leu 
        35                  40                  45              


Asn Gly Thr Thr Met Thr Leu Pro Ala Thr Thr Leu Thr Leu Ser Gly 
    50                  55                  60                  


His Tyr Ala Thr Ile Ser Leu Leu Thr Val Ser Gly Ala Trp Ala Lys 
65                  70                  75                  80  


Gln Met Phe Thr Cys Arg Val Ala His Thr Pro Ser Ser Thr Asp Trp 
                85                  90                  95      


Val Asp Asn Lys Thr Phe Ser Val Cys Ser Arg Asp Phe Thr Pro Pro 
            100                 105                 110         


Thr Val Lys Ile Leu Gln Ser Ser Cys Asp Gly Gly Gly His Phe Pro 
        115                 120                 125             


Pro Thr Ile Gln Leu Leu Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr 
    130                 135                 140                 


Ile Asn Ile Thr Trp Leu Glu Asp Gly Gln Val Met Asp Val Asp Leu 
145                 150                 155                 160 


Ser Thr Ala Ser Thr Thr Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser 
                165                 170                 175     


Glu Leu Thr Leu Ser Gln Lys His Trp Leu Ser Asp Arg Thr Tyr Thr 
            180                 185                 190         


Cys Gln Val Thr Tyr Gln Gly His Thr Phe Glu Asp Ser Thr Lys Lys 
        195                 200                 205             


Cys Ala Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro 
    210                 215                 220                 


Ser Pro Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu 
225                 230                 235                 240 


Val Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser 
                245                 250                 255     


Arg Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys 
            260                 265                 270         


Gln Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr 
        275                 280                 285             


Arg Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro 
    290                 295                 300                 


His Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro 
305                 310                 315                 320 


Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly 
                325                 330                 335     


Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro 
            340                 345                 350         


Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp 
        355                 360                 365             


Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe 
    370                 375                 380                 


Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys 
385                 390                 395                 400 


Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro Ser Gln 
                405                 410                 415     


Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
            420                 425             


<210>  14
<211>  453
<212>  PRT
<213>  artificial sequence

<220>
<223>  Uniprot P01871, IGHM_HUMAN, immunoglobulin heavy constant mu

<400>  14

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala 
                405                 410                 415     


His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser 
            420                 425                 430         


Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr 
        435                 440                 445             


Ala Gly Thr Cys Tyr 
    450             


<210>  15
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Spacer 1

<400>  15

Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   


<210>  16
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  16

Gly Gly Gly Ser Gly 
1               5   


<210>  17
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  human Ig kappa signal peptide

<400>  17

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly 
            20  


<210>  18
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  GM-CSF signal peptide

<400>  18

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  19
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  EGFR signal peptide

<400>  19

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala 
            20                  


<210>  20
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  human CD33 signal peptide

<400>  20

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210>  21
<211>  2
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Gly may be repeated by an integer from 1 to 100.

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Wherein the sequence may be repeated by an integer from 1 to 100.

<400>  21

Gly Ser 
1       


<210>  22
<211>  2
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (0)..(1)
<223>  Wherein Ser may be repeated by an integer from 1 to 100.

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Gly may be repeated by an integer from 1 to  4.

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Wherein The sequence may be repeated by an integer from 1 to 50.

<400>  22

Gly Ser 
1       


<210>  23
<211>  1
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Gly can be repeated between 1 to 100.

<400>  23

Gly 
1   


<210>  24
<211>  2
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Wherein Gly Ala may be repeated between 1 and 100.

<400>  24

Gly Ala 
1       


<210>  25
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  25

Gly Gly Gly Gly 
1               


<210>  26
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  26

Gly Gly Gly Ser Gly 
1               5   


<210>  27
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Wherein the sequence can be repeated between an integer of 1 and 
       100

<400>  27

Gly Gly Gly Ser Gly 
1               5   


<210>  28
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Wherein the sequence can be repeated between an integer of 1 and 
       100.

<400>  28

Gly Gly Gly Gly Ser 
1               5   


<210>  29
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Wherein the sequence can be repeated between an integer of 1 and 
       100

<400>  29

Gly Gly Gly Ser 
1               


<210>  30
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Wherein the sequence can be repeated between an integer of 1 and 
       100

<400>  30

Gly Gly Ser 
1           


<210>  31
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  31

Gly Ser Gly Ser Gly Ser 
1               5       


<210>  32
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  32

Gly Gly Ser Gly Gly 
1               5   


<210>  33
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  33

Ser Gly Gly Ser Gly Gly Ser 
1               5           


<210>  34
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  34

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly 
1               5                   10                  15  


<210>  35
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  35

Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  36
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  36

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  37
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  P2A

<400>  37

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  38
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  T2A

<400>  38

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  39
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  F2A

<400>  39

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  40
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2A

<400>  40

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  41
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  Furin Cleavage Site

<400>  41

Arg Ala Lys Arg 
1               


<210>  42
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Wherein the sequence can be repeated by a positive integer equal 
       to, or greater than 1

<400>  42

Gly Gly Gly Gly Ser 
1               5   


<210>  43
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  43

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  44
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  R12 VH

<400>  44

Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Ile Ser Ser 
        115                 120     


<210>  45
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  R12 VH CDR1

<400>  45

Ala Tyr Tyr Met Ser 
1               5   


<210>  46
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  R12 VH CDR2

<400>  46

Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val Asn 
1               5                   10                  15      


Gly 
    


<210>  47
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  R12 VH CDR3

<400>  47

Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile 
1               5                   10          


<210>  48
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  R12 VL

<400>  48

Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ser 
1               5                   10                  15      


Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala His Lys Thr Asp Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro 
65                  70                  75                  80  


Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Tyr 
                85                  90                  95      


Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         


<210>  49
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  R12 VL CDR1

<400>  49

Thr Leu Ser Ser Ala His Lys Thr Asp Thr Ile Asp 
1               5                   10          


<210>  50
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  R12 VL CDR2

<400>  50

Gly Ser Tyr Thr Lys Arg Pro 
1               5           


<210>  51
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  R12 VL CDR3

<400>  51

Gly Ala Asp Tyr Ile Gly Gly Tyr Val 
1               5                   


<210>  52
<211>  248
<212>  PRT
<213>  artificial sequence

<220>
<223>  R12 scFv

<400>  52

Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 


Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln 
                165                 170                 175     


Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         


Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             


Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Gln Leu Thr Val Thr Gly 
                245             


<210>  53
<211>  42
<212>  PRT
<213>  artificial sequence

<220>
<223>  4-1BB costimulatory domain

<400>  53

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  54
<211>  28
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD28 transmembrane domain

<400>  54

Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25              


<210>  55
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD3zeta activating domain

<400>  55

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  56
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  p2A

<400>  56

Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
1               5                   10                  15      


Val Glu Glu Asn Pro Gly Pro 
            20              


<210>  57
<211>  1198
<212>  PRT
<213>  artificial sequence

<220>
<223>  c-jun-anti-ROR1 CAR

<400>  57

Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
1               5                   10                  15      


Ser Phe Leu Pro Ser Glu Ser Gly Pro Tyr Gly Tyr Ser Asn Pro Lys 
            20                  25                  30          


Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser 
        35                  40                  45              


Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
    50                  55                  60                  


Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
65                  70                  75                  80  


Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                85                  90                  95      


Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
            100                 105                 110         


Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
        115                 120                 125             


Ser Val Thr Ser Ala Ala Gln Pro Val Asn Gly Ala Gly Met Val Ala 
    130                 135                 140                 


Pro Ala Val Ala Ser Val Ala Gly Gly Ser Gly Ser Gly Gly Phe Ser 
145                 150                 155                 160 


Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                165                 170                 175     


Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
            180                 185                 190         


Ala Gly Leu Ala Phe Pro Ala Gln Pro Gln Gln Gln Gln Gln Pro Pro 
        195                 200                 205             


His His Leu Pro Gln Gln Met Pro Val Gln His Pro Arg Leu Gln Ala 
    210                 215                 220                 


Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly Glu Thr Pro 
225                 230                 235                 240 


Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile Lys Ala Glu 
                245                 250                 255     


Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg 
            260                 265                 270         


Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys 
        275                 280                 285             


Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln 
    290                 295                 300                 


Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn Ser Gly Cys 
305                 310                 315                 320 


Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe Gly Ser Gly Ala Thr 
                325                 330                 335     


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            340                 345                 350         


Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile 
        355                 360                 365             


Ser Gly Ala Tyr Gly Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu 
    370                 375                 380                 


Val Thr Pro Gly Gly Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe 
385                 390                 395                 400 


Asp Phe Ser Ala Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                405                 410                 415     


Gly Leu Glu Trp Ile Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr 
            420                 425                 430         


Tyr Ala Thr Trp Val Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala 
        435                 440                 445             


Gln Asn Thr Val Asp Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg 
    450                 455                 460                 


Ala Thr Tyr Phe Cys Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu 
465                 470                 475                 480 


Phe Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val 
            500                 505                 510         


Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys 
        515                 520                 525             


Ile Thr Cys Thr Leu Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp 
    530                 535                 540                 


Tyr Gln Gln Leu Gln Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln 
545                 550                 555                 560 


Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser 
                565                 570                 575     


Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln 
            580                 585                 590         


Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Gly 
        595                 600                 605             


Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly Gly Gly Gly 
    610                 615                 620                 


Ser Gly Lys Pro Cys Pro Pro Cys Lys Cys Pro Met Phe Trp Val Leu 
625                 630                 635                 640 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
                645                 650                 655     


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            660                 665                 670         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        675                 680                 685             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    690                 695                 700                 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
705                 710                 715                 720 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                725                 730                 735     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            740                 745                 750         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        755                 760                 765             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    770                 775                 780                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
785                 790                 795                 800 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                805                 810                 815     


Arg Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
            820                 825                 830         


Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Val Thr Ser Leu Leu Leu 
        835                 840                 845             


Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys 
    850                 855                 860                 


Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala 
865                 870                 875                 880 


Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu 
                885                 890                 895     


His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro 
            900                 905                 910         


Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile 
        915                 920                 925             


Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu 
    930                 935                 940                 


His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His 
945                 950                 955                 960 


Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly 
                965                 970                 975     


Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly 
            980                 985                 990         


Asn Lys Asn Leu Cys Tyr Ala Asn  Thr Ile Asn Trp Lys  Lys Leu Phe 
        995                 1000                 1005             


Gly Thr  Ser Gly Gln Lys Thr  Lys Ile Ile Ser Asn  Arg Gly Glu 
    1010                 1015                 1020             


Asn Ser  Cys Lys Ala Thr Gly  Gln Val Cys His Ala  Leu Cys Ser 
    1025                 1030                 1035             


Pro Glu  Gly Cys Trp Gly Pro  Glu Pro Arg Asp Cys  Val Ser Cys 
    1040                 1045                 1050             


Arg Asn  Val Ser Arg Gly Arg  Glu Cys Val Asp Lys  Cys Asn Leu 
    1055                 1060                 1065             


Leu Glu  Gly Glu Pro Arg Glu  Phe Val Glu Asn Ser  Glu Cys Ile 
    1070                 1075                 1080             


Gln Cys  His Pro Glu Cys Leu  Pro Gln Ala Met Asn  Ile Thr Cys 
    1085                 1090                 1095             


Thr Gly  Arg Gly Pro Asp Asn  Cys Ile Gln Cys Ala  His Tyr Ile 
    1100                 1105                 1110             


Asp Gly  Pro His Cys Val Lys  Thr Cys Pro Ala Gly  Val Met Gly 
    1115                 1120                 1125             


Glu Asn  Asn Thr Leu Val Trp  Lys Tyr Ala Asp Ala  Gly His Val 
    1130                 1135                 1140             


Cys His  Leu Cys His Pro Asn  Cys Thr Tyr Gly Cys  Thr Gly Pro 
    1145                 1150                 1155             


Gly Leu  Glu Gly Cys Pro Thr  Asn Gly Pro Lys Ile  Pro Ser Ile 
    1160                 1165                 1170             


Ala Thr  Gly Met Val Gly Ala  Leu Leu Leu Leu Leu  Val Val Ala 
    1175                 1180                 1185             


Leu Gly  Ile Gly Leu Phe Met  Arg Arg Arg 
    1190                 1195             


<210>  58
<211>  4022
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA construct

<400>  58
tgaaagaccc cacctgtagg tttggcaagc taggatcaag gttaggaaca gagagacagc       60

agaatatggg ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag      120

aacagttgga acagcagaat atgggccaaa caggatatct gtggtaagca gttcctgccc      180

cggctcaggg ccaagaacag atggtcccca gatgcggtcc cgccctcagc agtttctaga      240

gaaccatcag atgtttccag ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga      300

actaaccaat cagttcgctt ctcgcttctg ttcgcgcgct tctgctcccc gagctcaata      360

aaagagccca caacccctca ctcggcgcga tcagaacctc ttacgagtcg gctagcgccg      420

ccaccatgac agccaagatg gaaaccacat tctacgacga cgccctgaac gcctcattcc      480

tgccttctga gagcggacct tacggctaca gcaatcctaa gatcctgaaa cagagcatga      540

cccttaacct ggctgatcct gttggaagcc tgaaacctca cctgagagcc aaaaacagcg      600

acctgctcac cagccctgat gtgggcctgc tgaagctggc ctctccagag ctggaacggc      660

tgatcatcca gagcagcaac ggccacatca caaccacccc tacccctaca caattcctgt      720

gccctaagaa cgtgaccgac gagcaggagg gcttcgccga aggctttgtg cgggccctgg      780

cagaactgca ctctcagaac accctgccta gcgtgacctc cgccgcccag cctgtcaacg      840

gcgccggaat ggtggcccct gccgtggctt ctgtggccgg cggcagcggc agcggcggat      900

tcagcgcctc tctgcactct gagcctcctg tctacgccaa tctgtctaat ttcaaccccg      960

gagccctgtc cagcggcggc ggagctccta gctacggcgc tgctggactg gccttccccg     1020

cccagcccca gcaacagcag cagcctccac accacctgcc ccagcagatg cccgtgcagc     1080

accctagact gcaggccctg aaggaagaac cccaaacagt gcctgagatg cctggcgaga     1140

cacctccact gagccccatc gacatggaaa gccaggagcg gatcaaggcc gagagaaaga     1200

gaatgcggaa cagaatcgcc gctagcaagt gcagaaagcg gaagctggaa agaatcgcca     1260

gactggaaga gaaggtgaag accctgaaag cccaaaatag cgagctggcc agcaccgcca     1320

acatgctgcg ggaacaggtg gcccagctga agcagaaggt gatgaaccac gtgaactctg     1380

gttgtcagct gatgctgacc cagcagctcc agaccttcgg ctccggtgca acgaacttca     1440

gcctgctgaa gcaggccgga gatgttgagg aaaatccagg tcccatggtc ttgcagactc     1500

aagtatttat atcccttttg ctctggatct ctggagctta cggccaggaa cagctcgtcg     1560

aaagcggcgg cagactggtg acacctggcg gcagcctgac cctgagctgc aaggccagcg     1620

gcttcgactt cagcgcctac tacatgagct gggtccgcca ggcccctggc aagggactgg     1680

aatggatcgc caccatctac cccagcagcg gcaagaccta ctacgccacc tgggtgaacg     1740

gacggttcac catctccagc gacaacgccc agaacaccgt ggacctgcag atgaacagcc     1800

tgacagccgc cgaccgggcc acctactttt gcgctcggga cagctacgcc gacgacggcg     1860

ccctgttcaa catctggggc cctggcaccc tggtgacaat ctctagcggc ggaggcggat     1920

ctggtggcgg aggaagtggc ggcggaggat ctgagctggt gctgacccag agcccctctg     1980

tgtctgctgc cctgggaagc cctgccaaga tcacctgtac cctgagcagc gcccacaaga     2040

ccgacaccat cgactggtat cagcagctgc agggcgaggc ccccagatac ctgatgcagg     2100

tgcagagcga cggcagctac accaagaggc caggcgtgcc cgacaggttc agcggatcta     2160

gctctggcgc cgaccgctac ctgatcatcc ccagcgtgca ggccgatgac gaggccgatt     2220

actactgtgg cgccgactac atcggcggct acgtgttcgg cggaggcacc cagctgaccg     2280

tgaccggtgg cggaggttca ggcaaaccgt gccctccgtg caagtgtcct atgttctggg     2340

tgctggtggt ggtcggaggc gtgctggcct gctacagcct gctggtcacc gtggccttca     2400

tcatcttttg ggtgaaacgg ggcagaaaga aactcctgta tatattcaaa caaccattta     2460

tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt ccagaagaag     2520

aagaaggagg atgtgaactg cgggtgaagt tcagcagaag cgccgacgcc cctgcctacc     2580

agcagggcca gaatcagctg tacaacgagc tgaacctggg cagaagggaa gagtacgacg     2640

tcctggataa gcggagaggc cgggaccctg agatgggcgg caagcctcgg cggaagaacc     2700

cccaggaagg cctgtataac gaactgcaga aagacaagat ggccgaggcc tacagcgaga     2760

tcggcatgaa gggcgagcgg aggcggggca agggccacga cggcctgtat cagggcctgt     2820

ccaccgccac caaggatacc tacgacgccc tgcacatgca ggccctgccc ccaaggtccg     2880

gagccactaa cttctccctg ttgaaacaag caggggatgt cgaagagaat cccgggccaa     2940

tgcttctcct ggtgacaagc cttctgctct gtgaattacc acacccagca ttcctcctga     3000

tcccacgcaa agtgtgcaac ggaataggta ttggtgaatt taaggactca ctctccataa     3060

atgctacgaa tattaaacac ttcaaaaact gcacctccat cagtggcgat ctccacatcc     3120

tgccggtggc atttaggggt gactccttca cacatactcc tcctctggac ccacaagaac     3180

tggatattct gaaaaccgta aaggaaatca cagggttttt gctgattcaa gcttggcctg     3240

aaaacaggac ggacctccat gcctttgaga acctagaaat catacgcggc aggaccaagc     3300

agcatggaca gttttctctt gctgtcgtga gcctgaacat aacatccttg ggattacgct     3360

ccctcaagga gataagtgat ggagatgtga taatttcagg aaacaaaaat ttgtgctatg     3420

caaatacaat aaactggaaa aaactgtttg ggacctccgg ccagaaaacc aaaattataa     3480

gcaacagagg cgaaaacagc tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc     3540

ccgagggctg ctggggcccg gagcccaggg attgcgtgtc ttgccggaat gtcagccgag     3600

gcagggaatg cgtggacaag tgcaaccttc tggaaggcga gccaagggag tttgtggaga     3660

actctgagtg catacagtgc cacccagagt gcctgcctca ggccatgaac atcacctgca     3720

caggacgggg accagacaac tgtatccagt gtgcccacta cattgacggc ccccactgcg     3780

tcaagacctg cccggcagga gtcatgggag aaaacaacac cctggtctgg aagtacgcag     3840

acgccggcca tgtgtgccac ctgtgccatc caaactgcac ctacggatgc actgggccag     3900

gtcttgaagg ctgtccaacg aacgggccta agatcccgtc catcgccact gggatggtgg     3960

gggccctcct cttgctgctg gtggtggccc tggggatcgg cctcttcatg cgccgaaggt     4020

ga                                                                    4022


<210>  59
<211>  352
<212>  PRT
<213>  artificial sequence

<220>
<223>  c-Jun after P2A cleavage

<400>  59

Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
1               5                   10                  15      


Ser Phe Leu Pro Ser Glu Ser Gly Pro Tyr Gly Tyr Ser Asn Pro Lys 
            20                  25                  30          


Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser 
        35                  40                  45              


Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
    50                  55                  60                  


Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
65                  70                  75                  80  


Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                85                  90                  95      


Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
            100                 105                 110         


Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
        115                 120                 125             


Ser Val Thr Ser Ala Ala Gln Pro Val Asn Gly Ala Gly Met Val Ala 
    130                 135                 140                 


Pro Ala Val Ala Ser Val Ala Gly Gly Ser Gly Ser Gly Gly Phe Ser 
145                 150                 155                 160 


Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                165                 170                 175     


Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
            180                 185                 190         


Ala Gly Leu Ala Phe Pro Ala Gln Pro Gln Gln Gln Gln Gln Pro Pro 
        195                 200                 205             


His His Leu Pro Gln Gln Met Pro Val Gln His Pro Arg Leu Gln Ala 
    210                 215                 220                 


Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly Glu Thr Pro 
225                 230                 235                 240 


Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile Lys Ala Glu 
                245                 250                 255     


Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg 
            260                 265                 270         


Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys 
        275                 280                 285             


Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln 
    290                 295                 300                 


Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn Ser Gly Cys 
305                 310                 315                 320 


Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe Gly Ser Gly Ala Thr 
                325                 330                 335     


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            340                 345                 350         


<210>  60
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  hIgK after P2A cleavage

<400>  60

Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile 
1               5                   10                  15      


Ser Gly Ala Tyr Gly 
            20      


<210>  61
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD3z after P2A cleavage

<400>  61

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
        115                 120                 125             


Glu Asn Pro Gly Pro 
    130             


<210>  62
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  GMCSFR-alpha-SP after P2A cleavage

<400>  62

Pro Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His 
1               5                   10                  15      


Pro Ala Phe Leu Leu Ile Pro 
            20              


<210>  63
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  63

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  64
<211>  386
<212>  DNA
<213>  artificial sequence

<220>
<223>  MND promotor

<400>  64
tgaaagaccc cacctgtagg tttggcaagc taggatcaag gttaggaaca gagagacagc       60

agaatatggg ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag      120

aacagttgga acagcagaat atgggccaaa caggatatct gtggtaagca gttcctgccc      180

cggctcaggg ccaagaacag atggtcccca gatgcggtcc cgccctcagc agtttctaga      240

gaaccatcag atgtttccag ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga      300

actaaccaat cagttcgctt ctcgcttctg ttcgcgcgct tctgctcccc gagctcaata      360

aaagagccca caacccctca ctcggc                                           386


