                         SEQUENCE LISTING

<110>  Ϻ＼޹˾
 
<120>  CLDN6弰;

<130>  IEC210075PCT

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  15H2ɱ

<400>  1

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Phe Ser Ile Ile Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Phe Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  2
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  15H2ɱ

<400>  2

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Thr 
            20                  25                  30          


Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Asn Ala Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  3
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  15H2 HCDR1

<400>  3

Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr 
1               5                   


<210>  4
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  15H2 HCDR2

<400>  4

Ile Ser Tyr Asp Gly Ser Asn 
1               5           


<210>  5
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  15H2 HCDR3

<400>  5

Ala Arg Gly Gly Tyr Tyr Phe Asp Tyr 
1               5                   


<210>  6
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  15H2 LCDR1

<400>  6

Gln Ser Leu Leu Asn Thr Asn Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  7
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  15H2 LCDR2

<400>  7

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  15H2 LCDR3

<400>  8

Gln Gln His Tyr Asn Ala Pro Arg Thr 
1               5                   


<210>  9
<211>  121
<212>  PRT
<213>  artificial

<220>
<223>  7008-03ɱ

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Asp Ala Ser Tyr Thr Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Leu Gly Asp Asn Asp Arg Gly Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  10
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  7008-03ɱ

<400>  10

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Val Val His Val 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  11
<211>  121
<212>  PRT
<213>  artificial

<220>
<223>  9H3ɱ

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ser Pro Asp Arg Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Asp Gly Ser Tyr Thr Tyr Phe Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Leu Gly Asp Asn Asp Arg Gly Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  12
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  9H3ɱ

<400>  12

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Val Val His Val 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            100                 105                 110         


<210>  13
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  9H3 HCDR1

<400>  13

Gly Phe Thr Phe Ser Ile Tyr Gly 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  9H3 HCDR2

<400>  14

Ile Ser Arg Asp Gly Ser Tyr Thr 
1               5               


<210>  15
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  9H3 HCDR3

<400>  15

Val Arg Leu Gly Asp Asn Asp Arg Gly Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  16
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  9H3 LCDR1

<400>  16

Gln Ser Val Val His Val Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  9H3 LCDR2

<400>  17

Lys Val Ser Asn Arg Phe Pro 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  9H3 LCDR3

<400>  18

Phe Gln Gly Ser His Val Pro Arg Thr 
1               5                   


<210>  19
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  7008-01ɱ

<400>  19

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  20
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  7008-01ɱ

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Thr 
            20                  25                  30          


Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Asn Ala Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  21
<211>  330
<212>  PRT
<213>  artificial

<220>
<223>  IgG1㶨

<400>  21

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  22
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  ˦㶨

<400>  22

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  23
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  7008-03 HCDR2

<400>  23

Ile Ser Arg Asp Ala Ser Tyr Thr 
1               5               


<210>  24
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  7008-03 LCDR1

<400>  24

Gln Ser Val Val His Val Asn Ala Asn Thr Tyr 
1               5                   10      


<210>  25
<211>  348
<212>  DNA
<213>  artificial

<220>
<223>  15H2ɱ

<400>  25
gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag      120

tttccaggaa acaaactgga atggatgggc tacataagct acgacggtag caataactac      180

aacccatctc tcaaaaatcg attctccatc attcgtgaca catctaagaa ccagtttttc      240

ctgaagttca attctgtgac tactgaggac acagctacat attactgcgc cagggggggg      300

tactactttg actactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  26
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  15H2ɱ

<400>  26
gacattgtga tgacacagtc tccatcctcc ctggctatgt cagtaggaca gaaggtcact       60

atgagctgca agtccagtca gagcctttta aatactaaca atcaaaagaa ctatttggcc      120

tggtaccagc agaaaccagg acagtctcct aaacttctgg tatactttgc atccactagg      180

gagtctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gattacttct gtcaacaaca ttataacgct      300

cctcggacgt tcggtggagg caccaagctg gaaatcaaa                             339


<210>  27
<211>  363
<212>  DNA
<213>  artificial

<220>
<223>  9H3ɱ

<400>  27
gaggtgcagc tggtggaatc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt atctatggca tgtcttgggt tcgccagagt      120

ccagacagga ggctggaatg ggtcgcaacc attagtcgtg atggtagtta cacctacttt      180

ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtat      240

ttgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgt aagactgggt      300

gataacgaca ggggctatgc tatggactac tggggtcaag gaacttcagt caccgtctcc      360

tca                                                                    363


<210>  28
<211>  336
<212>  DNA
<213>  artificial

<220>
<223>  9H3ɱ

<400>  28
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagtgttgta catgttaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaagg ctcctgatct acaaagtttc caaccgcttt      180

cctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaggatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct      300

cggacgttcg gtggaggcac caacctggaa atcaaa                                336


<210>  29
<211>  348
<212>  DNA
<213>  artificial

<220>
<223>  7008-01ɱ

<400>  29
caggtgcagc tgcaggagag cggccccgga ctggtgaagc cctcagagac actgagcctg       60

acatgcacag tgagcggcta ctccattaca agcggctact actggaactg gatcagacag      120

ccccccggca agggcctgga atggatgggc tatatctcct acagcggcag caacaactac      180

aaccccagcc tgaagaacag ggtgaccatc tctcgcgaca cctccaagaa ccagttctcc      240

ctgaagctga gtagcgtgac tgccgctgac accgccgtgt actattgcgc cagaggcggc      300

tactacttcg actactgggg ccagggcacc ctggtgaccg tgagcagc                   348


<210>  30
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  7008-01ɱ

<400>  30
gacattgtga tgacccagag ccccgactcc ctggccgtga gcctgggaga aagagccacc       60

atcaactgca agagcagcca gagcctgctg aacaccaaca accagaaaaa ctacctggcc      120

tggtaccagc agaaacccgg ccagcccccc aaactgctga tctacttcgc ctccacccgc      180

gagtccggcg tgcctgatag attctccggc agcggcagcg gcaccgactt caccctgact      240

atcagcagcc tgcaggctga ggacgtggcc gtgtacttct gccagcagca ttacaacgct      300

cccagaacct ttggaggagg caccaaggtg gaaatcaag                             339


<210>  31
<211>  363
<212>  DNA
<213>  artificial

<220>
<223>  7008-03ɱ

<400>  31
gaggtgcagc tggtggagag cgggggggga ctggtgcagc caggaggaag cctgagactg       60

agctgtgccg ccagcgggtt tacatttagc atttatggga tgtcctgggt gagacaggcc      120

cccggaaaag gactggagtg ggtggctact atcagcagag acgctagcta cacctacttc      180

cccgattccg tgaagggcag attcacaatc agcagagata acgctaagaa cagcctgtat      240

ctgcagatga acagcctgcg ggccgaggac acagccgtgt attactgcgt gaggctgggc      300

gacaacgata gaggatacgc catggactac tgggggcagg gaacactggt gaccgtgagc      360

agc                                                                    363


<210>  32
<211>  336
<212>  DNA
<213>  artificial

<220>
<223>  7008-03ɱ

<400>  32
gacgtggtga tgacccagag ccccctgagc ctgcccgtga ccctgggaca gcccgctagt       60

atcagctgca gaagcagcca gagcgtggtg cacgtgaacg ccaacacata tctggagtgg      120

tatcagcaga ggcctggaca gagccccaga ctgctgatct acaaggtgag caacagattc      180

ccaggcgtgc cagacagatt ctctggaagc ggcagcggaa cagactttac cctgaagatc      240

tccagagtgg aggccgagga cgtgggagtg tactactgct tccagggcag ccacgtgccc      300

agaacattcg gcggcggcac caaagtggag atcaaa                                336


<210>  33
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  7008-01 HCDR2

<400>  33

Ile Ser Tyr Ser Gly Ser Asn 
1               5           


