                         SEQUENCE LISTING

<110>  NantBio, Inc.
 
<120>  Anti-CD30 monoclonal antibodies and chimeric antigen receptors

<130>  102719.0034PRO

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-2 VH amino acid sequence

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Phe Met Pro Phe Ile Pro Asn Thr Leu Gly Phe Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-2 VL amino acid sequence

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Asp Ala Asp Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  3
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-5 VH amino acid sequence

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Phe Met Pro Phe Ile Pro Asn Thr Leu Gly Phe Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-5 VL amino acid sequence

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Asp Ala Asp Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  5
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-38 VH amino acid sequence

<400>  5

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Ala Ile Ser Trp Ser Gly Asp Ser Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Ser Ala Thr Trp Tyr Tyr Leu Gly Leu Gly Phe 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  6
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-38 VL amino acid sequence

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Val Ala Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-2 CDR-H1

<400>  7

Ser Tyr Tyr Met His 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-2 CDR-H2

<400>  8

Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-2 CDR-H3

<400>  9

Asp Arg Phe Met Pro Phe Ile Pro Asn Thr Leu Gly Phe Asp Val 
1               5                   10                  15  


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-2 CDR-L1

<400>  10

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-2 CDR-L2

<400>  11

Val Ala Ser Asn Leu Glu Thr 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-2 CDR-L3

<400>  12

Gln Gln Asp Ala Asp Val Pro Leu Thr 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-5 CDR-H1

<400>  13

Ser Tyr Tyr Met His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-5 CDR-H2

<400>  14

Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-5 CDR-H3

<400>  15

Asp Arg Phe Met Pro Phe Ile Pro Asn Thr Leu Gly Phe Asp Val 
1               5                   10                  15  


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-5 CDR-L1

<400>  16

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-5 CDR-L2

<400>  17

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-5 CDR-L3

<400>  18

Gln Gln Asp Ala Asp Val Pro Leu Thr 
1               5                   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-38 CDR-H1

<400>  19

Ser Tyr Trp Met His 
1               5   


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-38 CDR-H2

<400>  20

Ala Ile Ser Trp Ser Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-38 CDR-H3

<400>  21

Asp Arg Ser Ala Thr Trp Tyr Tyr Leu Gly Leu Gly Phe Asp Val 
1               5                   10                  15  


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-38 CDR-L1

<400>  22

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-38 CDR-L2

<400>  23

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-38 CDR-L3

<400>  24

Gln Gln Val Ala Asn Val Pro Leu Thr 
1               5                   


