                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  LONG ACTING AMYLIN RECEPTOR AGONISTS AND USES THEREOF

<130>  X22942

<150>  US 63/155,894
<151>  2021-03-03

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is gamma-Glu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is alpha-methyl-Phe

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is N-methyl-Asn

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  1

Xaa Cys Asn Thr Ala Thr Cys Ala Thr Gly Xaa Leu Ala Glu Xaa Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Xaa Phe Gly Pro Lys Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  2
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is gamma-Glu

<220>
<221>  MOD_RES
<222>  (2)..(7)
<223>  There is a thioacetal bridge between the cysteines at positions 2
       and 7

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is alpha-methyl-Phe

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is N-methyl-Asn

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  The lysine at position 26 is attached to a fatty acid linker 
       moiety according to the formula (gamma-Glu)2-CO-(CH2)18-CO2H

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  2

Xaa Cys Asn Thr Ala Thr Cys Ala Thr Gly Xaa Leu Ala Glu Xaa Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Xaa Phe Gly Pro Lys Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  3
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is gamma-Glu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is alpha-methyl-Phe

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is N-methyl-Asp

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  3

Xaa Cys Asn Thr Ala Thr Cys Ala Thr Gly Xaa Leu Ala Glu Xaa Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Xaa Phe Gly Pro Lys Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  4
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is gamma-Glu

<220>
<221>  MOD_RES
<222>  (2)..(7)
<223>  There is a thioacetal bridge between the cysteines at positions 2
       and 7

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is alpha-methyl-Phe

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is N-methyl-Asp

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  The lysine at position 26 is attached to a fatty acid linker 
       moiety according to the formula (gamma-Glu)2-CO-(CH2)18-CO2H

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  4

Xaa Cys Asn Thr Ala Thr Cys Ala Thr Gly Xaa Leu Ala Glu Xaa Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Xaa Phe Gly Pro Lys Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  5
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is alpha-methyl-Phe

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is N-methyl-Asp

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  5

Lys Cys Glu Thr Ala Thr Cys Ala Thr Gly Xaa Leu Ala Glu Xaa Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Xaa Phe Gly Pro Ile Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  6
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  The lysine at position 1 is attached to a fatty acid linker 
       moiety according to the formula (gamma-Glu)2-CO-(CH2)18-CO2H

<220>
<221>  MOD_RES
<222>  (2)..(7)
<223>  There is a thioacetal bridge between the cysteines at positions 2
       and 7

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is alpha-methyl-Phe

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is N-methyl-Asp

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  6

Lys Cys Glu Thr Ala Thr Cys Ala Thr Gly Xaa Leu Ala Glu Xaa Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Xaa Phe Gly Pro Ile Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  7
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is alpha-Methyl-Leu

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  7

Lys Cys Glu Thr Ala Thr Cys Ala Thr Gly Xaa Xaa Ala Glu Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser His Asn Phe Gly Pro Ile Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  8
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  The lysine at position 1 is attached to a fatty acid linker 
       moiety according to the formula (gamma-Glu)2-CO-(CH2)18-CO2H

<220>
<221>  MOD_RES
<222>  (2)..(7)
<223>  There is a thioacetal bridge between the cysteines at positions 2
       and 7

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is alpha-Methyl-Leu

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  8

Lys Cys Glu Thr Ala Thr Cys Ala Thr Gly Xaa Xaa Ala Glu Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser His Asn Phe Gly Pro Ile Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  9
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is gamma-Glu

<220>
<221>  MOD_RES
<222>  (2)..(7)
<223>  There is a thioacetal bridge between the cysteines at positions 2
       and 7

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  The lysine at position 26 is attached to a fatty acid linker 
       moiety according to the formula 
       (AEEA)2-(gamma-Glu)-CO-(CH2)18-CO2H

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  9

Xaa Cys Asn Thr Ala Thr Cys Ala Thr Gly Lys Leu Ala Glu Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  10
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is gamma-Glu

<220>
<221>  MOD_RES
<222>  (2)..(7)
<223>  There is a thioacetal bridge between the cysteines at positions 2
       and 7

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  The lysine at position 26 is attached to a fatty acid linker 
       moiety according to the formula 
       (gamma-Glu)-(AEEA)2-CO-(CH2)18-CO2H

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  10

Xaa Cys Asn Thr Ala Thr Cys Ala Thr Gly Lys Leu Ala Glu Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  11
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is gamma-Glu

<220>
<221>  MOD_RES
<222>  (2)..(7)
<223>  There is a thioacetal bridge between the cysteines at positions 2
       and 7

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  The lysine at position 26 is attached to a fatty acid linker 
       moiety according to the formula (gamma-Glu)2-AEEA-CO-(CH2)18-CO2H

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  11

Xaa Cys Asn Thr Ala Thr Cys Ala Thr Gly Lys Leu Ala Glu Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  12
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is gamma-Glu

<220>
<221>  MOD_RES
<222>  (2)..(7)
<223>  There is a thioacetal bridge between the cysteines at positions 2
       and 7

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  The lysine at position 26 is attached to a fatty acid linker 
       moiety according to the formula 
       (AEEA)2-(gamma-Glu)-CO-(CH2)18-CO2H

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  12

Xaa Cys Asn Thr Ala Thr Cys Ala Thr Gln Xaa Leu Ala Glu Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  13
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is gamma-Glu

<220>
<221>  MOD_RES
<222>  (2)..(7)
<223>  There is a thioacetal bridge between the cysteines at positions 2
       and 7

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  The lysine at position 26 is attached to a fatty acid linker 
       moiety according to the formula (gamma-Glu)2-CO-(CH2)18-CO2H

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  13

Xaa Cys Gly Thr Ala Thr Cys Ala Thr Gly Xaa Leu Ala Glu Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Phe Gly Pro Lys Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  14
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Lys or gamma-Glu

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Glu, Asn, or Gly

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is Gly or Gln

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn or Lys

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Leu or alpha-methyl-Leu

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is alpha-methyl-Phe or Phe

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is Asn or His

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is N-methyl-Asp, N-methyl-Asn, or Asn

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa at position 26 is Ile or Lys

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  C-terminus is amidated

<400>  14

Xaa Cys Xaa Thr Ala Thr Cys Ala Thr Xaa Xaa Xaa Ala Glu Xaa Leu 
1               5                   10                  15      


Val Arg Ser Ser Xaa Xaa Phe Gly Pro Xaa Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  15
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  DISULFID
<222>  (2)..(7)

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  15

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  16
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DISULFID
<222>  (1)..(7)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  Pro at position 32 is amidated

<400>  16

Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr Thr Gln Asp Phe 
1               5                   10                  15      


Asn Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly Val Gly Ala Pro 
            20                  25                  30          


<210>  17
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DISULFID
<222>  (2)..(7)

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tyr at position 37 is amidated

<400>  17

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  18
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  The lysine at position 20 is attached to a fatty acid linker 
       moiety according to the formula 
       (2-[2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)16-CO
       2H

<400>  18

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  19
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys at position 20 is chemically modified by conjugation of the 
       epsilon-amino group of the Lys side chain with 
       (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)18-CO
       2H

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  Gly at position 34 is amidated

<400>  19

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Lys Ala Lys Glu Phe Val Glu Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly 
        


<210>  20
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is alpha-Methyl-Leu

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Lys at position 17 is chemically modified by conjugation of the 
       epsilon-amino group of the Lys side chain with 
       (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)18-CO2
       H

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser at position 39 is amidated

<400>  20

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Lys Ala Gln Xaa Ala Phe Ile Glu Tyr Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  21
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Aib

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  K at position 20 is chemically modified through conjugation to 
       the epsilon-amino group of the K side-chain with 
       (2-[2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)1-CO-(CH2)18-C
       O2H

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Serine is amidated as a C-terminal primary amide

<400>  21

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  22
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is gamma-Glu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is alpha-Me-Phe

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is N-Me-Asn

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tys at position 37 is amidated

<400>  22

Xaa Cys Asn Thr Ala Thr Cys Ala Thr Gly Xaa Leu Ala Glu Xaa Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Xaa Phe Gly Pro Lys Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  23
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is gamma-Glu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is alpha-Me-Phe

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is N-Me-Asp

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tys at position 37 is amidated

<400>  23

Xaa Cys Asn Thr Ala Thr Cys Ala Thr Gly Xaa Leu Ala Glu Xaa Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Xaa Phe Gly Pro Lys Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  24
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is alpha-Me-Phe

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is N-Me-Asp

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tys at position 37 is amidated

<400>  24

Lys Cys Glu Thr Ala Thr Cys Ala Thr Gly Xaa Leu Ala Glu Xaa Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Xaa Phe Gly Pro Ile Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  25
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Orn

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is alpha-Me-Leu

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  Tys at position 37 is amidated

<400>  25

Lys Cys Glu Thr Ala Thr Cys Ala Thr Gly Xaa Xaa Ala Glu Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser His Asn Phe Gly Pro Ile Leu Pro Pro Thr Glu Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


