                         SEQUENCE LISTING

<110>  Redbiotec AG
 
<120>  Vaccine compositions and methods for treating HSV

<130>  RBT17324PCT

<150>  EP21162170
<151>  2021-03-11

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  96
<212>  PRT
<213>  human herpesvirus 2

<400>  1

Met Gly Leu Ala Phe Ser Gly Ala Arg Pro Cys Cys Cys Arg His Asn 
1               5                   10                  15      


Val Ile Ile Thr Asp Gly Gly Glu Val Val Ser Leu Thr Ala His Glu 
            20                  25                  30          


Phe Asp Val Val Asp Ile Glu Ser Glu Glu Glu Gly Asn Phe Tyr Val 
        35                  40                  45              


Pro Pro Asp Met Arg Val Val Thr Arg Ala Pro Gly Pro Gln Tyr Arg 
    50                  55                  60                  


Arg Ala Ser Asp Pro Pro Ser Arg His Thr Arg Arg Arg Asp Pro Asp 
65                  70                  75                  80  


Val Ala Arg Pro Pro Ala Thr Leu Thr Pro Pro Leu Ser Asp Ser Glu 
                85                  90                  95      


<210>  2
<211>  372
<212>  PRT
<213>  human herpesvirus 2

<400>  2

Met Ala Gln Arg Ala Leu Trp Arg Pro Gln Ala Thr Pro Gly Pro Pro 
1               5                   10                  15      


Gly Ala Ala Ala Pro Pro Gly His Arg Gly Ala Pro Pro Asp Ala Arg 
            20                  25                  30          


Ala Pro Asp Pro Gly Pro Glu Ala Asp Leu Val Ala Arg Ile Ala Asn 
        35                  40                  45              


Ser Val Phe Val Trp Arg Val Val Arg Gly Asp Glu Arg Leu Lys Ile 
    50                  55                  60                  


Phe Arg Cys Leu Thr Val Leu Thr Glu Pro Leu Cys Gln Val Ala Leu 
65                  70                  75                  80  


Pro Asp Pro Asp Pro Glu Arg Ala Leu Phe Cys Glu Ile Phe Leu Tyr 
                85                  90                  95      


Leu Thr Arg Pro Lys Ala Leu Arg Leu Pro Ser Asn Thr Phe Phe Ala 
            100                 105                 110         


Ile Phe Phe Phe Asn Arg Glu Arg Arg Tyr Cys Ala Thr Val His Leu 
        115                 120                 125             


Arg Ser Val Thr His Pro Arg Thr Pro Leu Leu Cys Thr Leu Ala Phe 
    130                 135                 140                 


Gly His Leu Glu Ala Ala Ser Pro Pro Glu Glu Thr Pro Asp Pro Ala 
145                 150                 155                 160 


Ala Glu Gln Leu Ala Asp Glu Pro Val Ala His Glu Leu Asp Gly Ala 
                165                 170                 175     


Tyr Leu Val Pro Thr Glu Pro Pro Pro Asn Pro Gly Ala Cys Cys Ala 
            180                 185                 190         


Leu Gly Pro Gly Ala Trp Trp His Leu Pro Gly Gly Arg Ile Tyr Cys 
        195                 200                 205             


Trp Ala Met Asp Asp Asp Leu Gly Ser Leu Cys Pro Pro Gly Ser Arg 
    210                 215                 220                 


Ala Arg His Leu Gly Trp Leu Leu Ser Arg Ile Thr Asp Pro Pro Gly 
225                 230                 235                 240 


Gly Gly Gly Ala Cys Ala Pro Thr Ala His Ile Asp Ser Ala Asn Ala 
                245                 250                 255     


Leu Trp Arg Ala Pro Ala Val Ala Glu Ala Cys Pro Cys Val Ala Pro 
            260                 265                 270         


Cys Met Trp Ser Asn Met Ala Gln Arg Thr Leu Ala Val Arg Gly Asp 
        275                 280                 285             


Ala Ser Leu Cys Gln Leu Leu Phe Gly His Pro Val Asp Ala Val Ile 
    290                 295                 300                 


Leu Arg Gln Ala Thr Arg Arg Pro Arg Ile Thr Ala His Leu His Glu 
305                 310                 315                 320 


Val Val Val Gly Arg Asp Gly Ala Glu Ser Val Ile Arg Pro Thr Ser 
                325                 330                 335     


Ala Gly Trp Arg Leu Cys Val Leu Ser Ser Tyr Thr Ser Arg Leu Phe 
            340                 345                 350         


Ala Thr Ser Cys Pro Ala Val Ala Arg Ala Val Ala Arg Ala Ser Ser 
        355                 360                 365             


Ser Asp Tyr Lys 
    370         


<210>  3
<211>  532
<212>  PRT
<213>  human herpesvirus 2

<400>  3

Met Glu Leu Ser Tyr Ala Thr Thr Leu His His Arg Asp Val Val Phe 
1               5                   10                  15      


Tyr Val Thr Ala Asp Arg Asn Arg Ala Tyr Phe Val Cys Gly Gly Ser 
            20                  25                  30          


Val Tyr Ser Val Gly Arg Pro Arg Asp Ser Gln Pro Gly Glu Ile Ala 
        35                  40                  45              


Lys Phe Gly Leu Val Val Arg Gly Thr Gly Pro Lys Asp Arg Met Val 
    50                  55                  60                  


Ala Asn Tyr Val Arg Ser Glu Leu Arg Gln Arg Gly Leu Arg Asp Val 
65                  70                  75                  80  


Arg Pro Val Gly Glu Asp Glu Val Phe Leu Asp Ser Val Cys Leu Leu 
                85                  90                  95      


Asn Pro Asn Val Ser Ser Glu Arg Asp Val Ile Asn Thr Asn Asp Val 
            100                 105                 110         


Glu Val Leu Asp Glu Cys Leu Ala Glu Tyr Cys Thr Ser Leu Arg Thr 
        115                 120                 125             


Ser Pro Gly Val Leu Val Thr Gly Val Arg Val Arg Ala Arg Asp Arg 
    130                 135                 140                 


Val Ile Glu Leu Phe Glu His Pro Ala Ile Val Asn Ile Ser Ser Arg 
145                 150                 155                 160 


Phe Ala Tyr Thr Pro Ser Pro Tyr Val Phe Ala Leu Ala Gln Ala His 
                165                 170                 175     


Leu Pro Arg Leu Pro Ser Ser Leu Glu Pro Leu Val Ser Gly Leu Phe 
            180                 185                 190         


Asp Gly Ile Pro Ala Pro Arg Gln Pro Leu Asp Ala Arg Asp Arg Arg 
        195                 200                 205             


Thr Asp Val Val Ile Thr Gly Thr Arg Ala Pro Arg Pro Met Ala Gly 
    210                 215                 220                 


Thr Gly Ala Gly Gly Ala Gly Ala Lys Arg Ala Thr Val Ser Glu Phe 
225                 230                 235                 240 


Val Gln Val Lys His Ile Asp Arg Val Val Ser Pro Ser Val Ser Ser 
                245                 250                 255     


Ala Pro Pro Pro Ser Ala Pro Asp Ala Ser Leu Pro Pro Pro Gly Leu 
            260                 265                 270         


Gln Glu Ala Ala Pro Pro Gly Pro Pro Leu Arg Glu Leu Trp Trp Val 
        275                 280                 285             


Phe Tyr Ala Gly Asp Arg Ala Leu Glu Glu Pro His Ala Glu Ser Gly 
    290                 295                 300                 


Leu Thr Arg Glu Glu Val Arg Ala Val His Gly Phe Arg Glu Gln Ala 
305                 310                 315                 320 


Trp Lys Leu Phe Gly Ser Val Gly Ala Pro Arg Ala Phe Leu Gly Ala 
                325                 330                 335     


Ala Leu Ala Leu Ser Pro Thr Gln Lys Leu Ala Val Tyr Tyr Tyr Leu 
            340                 345                 350         


Ile His Arg Glu Arg Arg Met Ser Pro Phe Pro Ala Leu Val Arg Leu 
        355                 360                 365             


Val Gly Arg Tyr Ile Gln Arg His Gly Leu Tyr Val Pro Ala Pro Asp 
    370                 375                 380                 


Glu Pro Thr Leu Ala Asp Ala Met Asn Gly Leu Phe Arg Asp Ala Leu 
385                 390                 395                 400 


Ala Ala Gly Thr Val Ala Glu Gln Leu Leu Met Phe Asp Leu Leu Pro 
                405                 410                 415     


Pro Lys Asp Val Pro Val Gly Ser Asp Ala Arg Ala Asp Ser Ala Ala 
            420                 425                 430         


Leu Leu Arg Phe Val Asp Ser Gln Arg Leu Thr Pro Gly Gly Ser Val 
        435                 440                 445             


Ser Pro Glu His Val Met Tyr Leu Gly Ala Phe Leu Gly Val Leu Tyr 
    450                 455                 460                 


Ala Gly His Gly Arg Leu Ala Ala Ala Thr His Thr Ala Arg Leu Thr 
465                 470                 475                 480 


Gly Val Thr Ser Leu Val Leu Thr Val Gly Asp Val Asp Arg Met Ser 
                485                 490                 495     


Ala Phe Asp Arg Gly Pro Ala Gly Ala Ala Gly Arg Thr Arg Thr Ala 
            500                 505                 510         


Gly Tyr Leu Asp Ala Leu Leu Thr Val Cys Leu Ala Arg Ala Gln His 
        515                 520                 525             


Gly Gln Ser Val 
    530         


<210>  4
<211>  548
<212>  PRT
<213>  human herpesvirus 2

<400>  4

Met Ala Arg Gly Ala Gly Leu Val Phe Phe Val Gly Val Trp Val Val 
1               5                   10                  15      


Ser Cys Leu Ala Ala Ala Pro Arg Thr Ser Trp Lys Arg Val Thr Ser 
            20                  25                  30          


Gly Glu Asp Val Val Leu Leu Pro Ala Pro Ala Gly Pro Glu Glu Arg 
        35                  40                  45              


Thr Arg Ala His Lys Leu Leu Trp Ala Ala Glu Pro Leu Asp Ala Cys 
    50                  55                  60                  


Gly Pro Leu Arg Pro Ser Trp Val Ala Leu Trp Pro Pro Arg Arg Val 
65                  70                  75                  80  


Leu Glu Thr Val Val Asp Ala Ala Cys Met Arg Ala Pro Glu Pro Leu 
                85                  90                  95      


Ala Ile Ala Tyr Ser Pro Pro Phe Pro Ala Gly Asp Glu Gly Leu Tyr 
            100                 105                 110         


Ser Glu Leu Ala Trp Arg Asp Arg Val Ala Val Val Asn Glu Ser Leu 
        115                 120                 125             


Val Ile Tyr Gly Ala Leu Glu Thr Asp Ser Gly Leu Tyr Thr Leu Ser 
    130                 135                 140                 


Val Val Gly Leu Ser Asp Glu Ala Arg Gln Val Ala Ser Val Val Leu 
145                 150                 155                 160 


Val Val Glu Pro Ala Pro Val Pro Thr Pro Thr Pro Asp Asp Tyr Asp 
                165                 170                 175     


Glu Glu Asp Asp Ala Gly Val Ser Glu Arg Thr Pro Val Ser Val Pro 
            180                 185                 190         


Pro Pro Thr Pro Pro Arg Arg Pro Pro Val Ala Pro Pro Thr His Pro 
        195                 200                 205             


Arg Val Ile Pro Glu Val Ser His Val Arg Gly Val Thr Val His Met 
    210                 215                 220                 


Glu Thr Pro Glu Ala Ile Leu Phe Ala Pro Gly Glu Thr Phe Gly Thr 
225                 230                 235                 240 


Asn Val Ser Ile His Ala Ile Ala His Asp Asp Gly Pro Tyr Ala Met 
                245                 250                 255     


Asp Val Val Trp Met Arg Phe Asp Val Pro Ser Ser Cys Ala Glu Met 
            260                 265                 270         


Arg Ile Tyr Glu Ala Cys Leu Tyr His Pro Gln Leu Pro Glu Cys Leu 
        275                 280                 285             


Ser Pro Ala Asp Ala Pro Cys Ala Val Ser Ser Trp Ala Tyr Arg Leu 
    290                 295                 300                 


Ala Val Arg Ser Tyr Ala Gly Cys Ser Arg Thr Thr Pro Pro Pro Arg 
305                 310                 315                 320 


Cys Phe Ala Glu Ala Arg Met Glu Pro Val Pro Gly Leu Ala Trp Leu 
                325                 330                 335     


Ala Ser Thr Val Asn Leu Glu Phe Gln His Ala Ser Pro Gln His Ala 
            340                 345                 350         


Gly Leu Tyr Leu Cys Val Val Tyr Val Asp Asp His Ile His Ala Trp 
        355                 360                 365             


Gly His Met Thr Ile Ser Thr Ala Ala Gln Tyr Arg Asn Ala Val Val 
    370                 375                 380                 


Glu Gln His Leu Pro Gln Arg Gln Pro Glu Pro Val Glu Pro Thr Arg 
385                 390                 395                 400 


Pro His Val Arg Ala Pro Pro Pro Ala Pro Ser Ala Arg Gly Pro Leu 
                405                 410                 415     


Arg Leu Gly Ala Val Leu Gly Ala Ala Leu Leu Leu Ala Ala Leu Gly 
            420                 425                 430         


Leu Ser Ala Trp Ala Cys Met Thr Cys Trp Arg Arg Arg Ser Trp Arg 
        435                 440                 445             


Ala Val Lys Ser Arg Ala Ser Ala Thr Gly Pro Thr Tyr Ile Arg Val 
    450                 455                 460                 


Ala Asp Ser Glu Leu Tyr Ala Asp Trp Ser Ser Asp Ser Glu Gly Glu 
465                 470                 475                 480 


Arg Asp Gly Ser Leu Trp Gln Asp Pro Pro Glu Arg Pro Asp Ser Pro 
                485                 490                 495     


Ser Thr Asn Gly Ser Gly Phe Glu Ile Leu Ser Pro Thr Ala Pro Ser 
            500                 505                 510         


Val Tyr Pro His Ser Glu Gly Arg Lys Ser Arg Arg Pro Leu Thr Thr 
        515                 520                 525             


Phe Gly Ser Gly Ser Pro Gly Arg Arg His Ser Gln Ala Ser Tyr Ser 
    530                 535                 540                 


Ser Val Leu Trp 
545             


<210>  5
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytoplasmic tail of gE protein of HSV-2 (human herpesvirus 2)

<400>  5

Arg Arg Arg Ser Trp Arg Ala Val Lys Ser Arg Ala Ser Ala Thr Gly 
1               5                   10                  15      


Pro Thr Tyr Ile Arg Val Ala Asp Ser Glu Leu Tyr Ala Asp Trp Ser 
            20                  25                  30          


Ser Asp Ser Glu Gly Glu Arg Asp Gly Ser Leu Trp Gln Asp Pro Pro 
        35                  40                  45              


Glu Arg Pro Asp Ser Pro Ser Thr Asn Gly Ser Gly Phe Glu Ile Leu 
    50                  55                  60                  


Ser Pro Thr Ala Pro Ser Val Tyr Pro His Ser Glu Gly Arg Lys Ser 
65                  70                  75                  80  


Arg Arg Pro Leu Thr Thr Phe Gly Ser Gly Ser Pro Gly Arg Arg His 
                85                  90                  95      


Ser Gln Ala Ser Tyr Ser Ser Val Leu Trp 
            100                 105     


<210>  6
<211>  490
<212>  PRT
<213>  human herpesvirus 2

<400>  6

Met Asp Leu Leu Val Asp Asp Leu Phe Ala Asp Ala Asp Gly Val Ser 
1               5                   10                  15      


Pro Pro Pro Pro Arg Pro Ala Gly Gly Pro Lys Asn Thr Pro Ala Ala 
            20                  25                  30          


Pro Pro Leu Tyr Ala Thr Gly Arg Leu Ser Gln Ala Gln Leu Met Pro 
        35                  40                  45              


Ser Pro Pro Met Pro Val Pro Pro Ala Ala Leu Phe Asn Arg Leu Leu 
    50                  55                  60                  


Asp Asp Leu Gly Phe Ser Ala Gly Pro Ala Leu Cys Thr Met Leu Asp 
65                  70                  75                  80  


Thr Trp Asn Glu Asp Leu Phe Ser Gly Phe Pro Thr Asn Ala Asp Met 
                85                  90                  95      


Tyr Arg Glu Cys Lys Phe Leu Ser Thr Leu Pro Ser Asp Val Ile Asp 
            100                 105                 110         


Trp Gly Asp Ala His Val Pro Glu Arg Ser Pro Ile Asp Ile Arg Ala 
        115                 120                 125             


His Gly Asp Val Ala Phe Pro Thr Leu Pro Ala Thr Arg Asp Glu Leu 
    130                 135                 140                 


Pro Ser Tyr Tyr Glu Ala Met Ala Gln Phe Phe Arg Gly Glu Leu Arg 
145                 150                 155                 160 


Ala Arg Glu Glu Ser Tyr Arg Thr Val Leu Ala Asn Phe Cys Ser Ala 
                165                 170                 175     


Leu Tyr Arg Tyr Leu Arg Ala Ser Val Arg Gln Leu His Arg Gln Ala 
            180                 185                 190         


His Met Arg Gly Arg Asn Arg Asp Leu Arg Glu Met Leu Arg Thr Thr 
        195                 200                 205             


Ile Ala Asp Arg Tyr Tyr Arg Glu Thr Ala Arg Leu Ala Arg Val Leu 
    210                 215                 220                 


Phe Leu His Leu Tyr Leu Phe Leu Ser Arg Glu Ile Leu Trp Ala Ala 
225                 230                 235                 240 


Tyr Ala Glu Gln Met Met Arg Pro Asp Leu Phe Asp Gly Leu Cys Cys 
                245                 250                 255     


Asp Leu Glu Ser Trp Arg Gln Leu Ala Cys Leu Phe Gln Pro Leu Met 
            260                 265                 270         


Phe Ile Asn Gly Ser Leu Thr Val Arg Gly Val Pro Val Glu Ala Arg 
        275                 280                 285             


Arg Leu Arg Glu Leu Asn His Ile Arg Glu His Leu Asn Leu Pro Leu 
    290                 295                 300                 


Val Arg Ser Ala Ala Ala Glu Glu Pro Gly Ala Pro Leu Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Gln Gly Asn Gln Ala Arg Ser Ser Gly Tyr Phe Met Leu 
                325                 330                 335     


Leu Ile Arg Ala Lys Leu Asp Ser Tyr Ser Ser Val Ala Thr Ser Glu 
            340                 345                 350         


Gly Glu Ser Val Met Arg Glu His Ala Tyr Ser Arg Gly Arg Thr Arg 
        355                 360                 365             


Asn Asn Tyr Gly Ser Thr Ile Glu Gly Leu Leu Asp Leu Pro Asp Asp 
    370                 375                 380                 


Asp Asp Ala Pro Ala Glu Ala Gly Leu Val Ala Pro Arg Met Ser Phe 
385                 390                 395                 400 


Leu Ser Ala Gly Gln Arg Pro Arg Arg Leu Ser Thr Thr Ala Pro Ile 
                405                 410                 415     


Thr Asp Val Ser Leu Gly Asp Glu Leu Arg Leu Asp Gly Glu Glu Val 
            420                 425                 430         


Asp Met Thr Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Glu Met Leu 
        435                 440                 445             


Gly Asp Val Glu Ser Pro Ser Pro Gly Met Thr His Asp Pro Val Ser 
    450                 455                 460                 


Tyr Gly Ala Leu Asp Val Asp Asp Phe Glu Phe Glu Gln Met Phe Thr 
465                 470                 475                 480 


Asp Ala Met Gly Ile Asp Asp Phe Gly Gly 
                485                 490 


<210>  7
<211>  302
<212>  PRT
<213>  human herpesvirus 2

<400>  7

Met Thr Ser Arg Arg Ser Val Lys Ser Cys Pro Arg Glu Ala Pro Arg 
1               5                   10                  15      


Gly Thr His Glu Glu Leu Tyr Tyr Gly Pro Val Ser Pro Ala Asp Pro 
            20                  25                  30          


Glu Ser Pro Arg Asp Asp Phe Arg Arg Gly Ala Gly Pro Met Arg Ala 
        35                  40                  45              


Arg Pro Arg Gly Glu Val Arg Phe Leu His Tyr Asp Glu Ala Gly Tyr 
    50                  55                  60                  


Ala Leu Tyr Arg Asp Ser Ser Ser Ser Glu Asp Asn Asp Glu Ser Arg 
65                  70                  75                  80  


Asp Thr Ala Arg Pro Arg Arg Ser Ala Ser Val Ala Gly Ser His Gly 
                85                  90                  95      


Pro Gly Pro Ala Arg Ala Pro Pro Pro Pro Gly Gly Pro Val Gly Ala 
            100                 105                 110         


Gly Gly Arg Ser His Ala Pro Pro Ala Arg Thr Pro Lys Met Thr Arg 
        115                 120                 125             


Gly Ala Pro Lys Ala Pro Ala Thr Pro Ala Thr Asp Pro Ala Arg Gly 
    130                 135                 140                 


Arg Arg Pro Ala Gln Ala Asp Ser Ala Val Leu Leu Asp Ala Pro Ala 
145                 150                 155                 160 


Pro Thr Ala Ser Gly Arg Thr Lys Thr Pro Ala Gln Gly Leu Ala Lys 
                165                 170                 175     


Lys Leu His Phe Ser Thr Ala Pro Pro Ser Pro Thr Ala Pro Trp Thr 
            180                 185                 190         


Pro Arg Val Ala Gly Phe Asn Lys Arg Val Phe Cys Ala Ala Val Gly 
        195                 200                 205             


Arg Leu Ala Ala Thr His Ala Arg Leu Ala Ala Val Gln Leu Trp Asp 
    210                 215                 220                 


Met Ser Arg Pro His Thr Asp Glu Asp Leu Asn Glu Leu Leu Asp Leu 
225                 230                 235                 240 


Thr Thr Ile Arg Val Thr Val Cys Glu Gly Lys Asn Leu Leu Gln Arg 
                245                 250                 255     


Ala Asn Glu Leu Val Asn Pro Asp Ala Ala Gln Asp Val Asp Ala Thr 
            260                 265                 270         


Ala Ala Ala Arg Gly Arg Pro Ala Gly Arg Ala Ala Ala Thr Ala Arg 
        275                 280                 285             


Ala Pro Ala Arg Ser Ala Ser Arg Pro Arg Arg Pro Leu Glu 
    290                 295                 300         


<210>  8
<211>  305
<212>  PRT
<213>  human herpesvirus 2

<400>  8

Met Tyr Asp Ile Ala Pro Arg Arg Ser Gly Ser Arg Pro Gly Pro Gly 
1               5                   10                  15      


Arg Asp Lys Thr Arg Arg Arg Ser Arg Phe Ser Ala Ala Gly Asn Pro 
            20                  25                  30          


Gly Val Glu Arg Arg Ala Ser Arg Lys Ser Leu Pro Ser His Ala Arg 
        35                  40                  45              


Arg Leu Glu Leu Cys Leu His Glu Arg Arg Arg Tyr Arg Gly Phe Phe 
    50                  55                  60                  


Ala Ala Leu Ala Gln Thr Pro Ser Glu Glu Ile Ala Ile Val Arg Ser 
65                  70                  75                  80  


Leu Ser Val Pro Leu Val Lys Thr Thr Pro Val Ser Leu Pro Phe Ser 
                85                  90                  95      


Leu Asp Gln Thr Val Ala Asp Asn Cys Leu Thr Leu Ser Gly Met Gly 
            100                 105                 110         


Tyr Tyr Leu Gly Ile Gly Gly Cys Cys Pro Ala Cys Ser Ala Gly Asp 
        115                 120                 125             


Gly Arg Leu Ala Thr Val Ser Arg Glu Ala Leu Ile Leu Ala Phe Val 
    130                 135                 140                 


Gln Gln Ile Asn Thr Ile Phe Glu His Arg Thr Phe Leu Ala Ser Leu 
145                 150                 155                 160 


Val Val Leu Ala Asp Arg His Ser Thr Pro Leu Gln Asp Leu Leu Ala 
                165                 170                 175     


Asp Thr Leu Gly Gln Pro Glu Leu Phe Phe Val His Thr Ile Leu Arg 
            180                 185                 190         


Gly Gly Gly Ala Cys Asp Pro Arg Phe Leu Phe Tyr Pro Asp Pro Thr 
        195                 200                 205             


Tyr Gly Gly His Met Leu Tyr Val Ile Phe Pro Gly Thr Ser Ala His 
    210                 215                 220                 


Leu His Tyr Arg Leu Ile Asp Arg Met Leu Thr Ala Cys Pro Gly Tyr 
225                 230                 235                 240 


Arg Phe Ala Ala His Val Trp Gln Ser Thr Phe Val Leu Val Val Arg 
                245                 250                 255     


Arg Asn Ala Glu Lys Pro Ala Asp Ala Glu Ile Pro Thr Val Ser Ala 
            260                 265                 270         


Ala Asp Ile Tyr Cys Lys Met Arg Asp Ile Ser Phe Asp Gly Gly Leu 
        275                 280                 285             


Met Leu Glu Tyr Gln Arg Leu Tyr Ala Thr Phe Asp Glu Phe Pro Pro 
    290                 295                 300                 


Pro 
305 


<210>  9
<211>  250
<212>  PRT
<213>  human herpesvirus 2

<400>  9

Met Ala Gly Met Gly Lys Pro Tyr Gly Gly Arg Pro Gly Asp Ala Phe 
1               5                   10                  15      


Glu Gly Leu Val Gln Arg Ile Arg Leu Ile Val Pro Thr Thr Leu Arg 
            20                  25                  30          


Gly Gly Gly Gly Glu Ser Gly Pro Tyr Ser Pro Ser Asn Pro Pro Ser 
        35                  40                  45              


Arg Cys Ala Phe Gln Phe His Gly Gln Asp Gly Ser Asp Glu Ala Phe 
    50                  55                  60                  


Pro Ile Glu Tyr Val Leu Arg Leu Met Asn Asp Trp Ala Asp Val Pro 
65                  70                  75                  80  


Cys Asn Pro Tyr Leu Arg Val Gln Asn Thr Gly Val Ser Val Leu Phe 
                85                  90                  95      


Gln Gly Phe Phe Asn Arg Pro His Gly Ala Pro Gly Gly Ala Ile Thr 
            100                 105                 110         


Ala Glu Gln Thr Asn Val Ile Leu His Ser Thr Glu Thr Thr Gly Leu 
        115                 120                 125             


Ser Leu Gly Asp Leu Asp Asp Val Lys Gly Arg Leu Gly Leu Asp Ala 
    130                 135                 140                 


Arg Pro Met Met Ala Ser Met Trp Ile Ser Cys Phe Val Arg Met Pro 
145                 150                 155                 160 


Arg Val Gln Leu Ala Phe Arg Phe Met Gly Pro Glu Asp Ala Val Arg 
                165                 170                 175     


Thr Arg Arg Ile Leu Cys Arg Ala Ala Glu Gln Ala Leu Ala Arg Arg 
            180                 185                 190         


Arg Arg Ser Arg Arg Ser Gln Asp Asp Tyr Gly Ala Val Ala Val Ala 
        195                 200                 205             


Ala Ala His His Ser Ser Gly Ala Pro Gly Pro Gly Val Ala Ala Ser 
    210                 215                 220                 


Gly Pro Pro Ala Pro Pro Gly Arg Gly Pro Ala Arg Pro Trp His Gln 
225                 230                 235                 240 


Ala Val Gln Leu Phe Arg Ala Pro Arg Pro 
                245                 250 


<210>  10
<211>  904
<212>  PRT
<213>  human herpesvirus 2

<400>  10

Met Arg Gly Gly Gly Leu Ile Cys Ala Leu Val Val Gly Ala Leu Val 
1               5                   10                  15      


Ala Ala Val Ala Ser Ala Ala Pro Ala Ala Pro Ala Ala Pro Arg Ala 
            20                  25                  30          


Ser Gly Gly Val Ala Ala Thr Val Ala Ala Asn Gly Gly Pro Ala Ser 
        35                  40                  45              


Arg Pro Pro Pro Val Pro Ser Pro Ala Thr Thr Lys Ala Arg Lys Arg 
    50                  55                  60                  


Lys Thr Lys Lys Pro Pro Lys Arg Pro Glu Ala Thr Pro Pro Pro Asp 
65                  70                  75                  80  


Ala Asn Ala Thr Val Ala Ala Gly His Ala Thr Leu Arg Ala His Leu 
                85                  90                  95      


Arg Glu Ile Lys Val Glu Asn Ala Asp Ala Gln Phe Tyr Val Cys Pro 
            100                 105                 110         


Pro Pro Thr Gly Ala Thr Val Val Gln Phe Glu Gln Pro Arg Arg Cys 
        115                 120                 125             


Pro Thr Arg Pro Glu Gly Gln Asn Tyr Thr Glu Gly Ile Ala Val Val 
    130                 135                 140                 


Phe Lys Glu Asn Ile Ala Pro Tyr Lys Phe Lys Ala Thr Met Tyr Tyr 
145                 150                 155                 160 


Lys Asp Val Thr Val Ser Gln Val Trp Phe Gly His Arg Tyr Ser Gln 
                165                 170                 175     


Phe Met Gly Ile Phe Glu Asp Arg Ala Pro Val Pro Phe Glu Glu Val 
            180                 185                 190         


Ile Asp Lys Ile Asn Ala Lys Gly Val Cys Arg Ser Thr Ala Lys Tyr 
        195                 200                 205             


Val Arg Asn Asn Met Glu Thr Thr Ala Phe His Arg Asp Asp His Glu 
    210                 215                 220                 


Thr Asp Met Glu Leu Lys Pro Ala Lys Val Ala Thr Arg Thr Ser Arg 
225                 230                 235                 240 


Gly Trp His Thr Thr Asp Leu Lys Tyr Asn Pro Ser Arg Val Glu Ala 
                245                 250                 255     


Phe His Arg Tyr Gly Thr Thr Val Asn Cys Ile Val Glu Glu Val Asp 
            260                 265                 270         


Ala Arg Ser Val Tyr Pro Tyr Asp Glu Phe Val Leu Ala Thr Gly Asp 
        275                 280                 285             


Phe Val Tyr Met Ser Pro Phe Tyr Gly Tyr Arg Glu Gly Ser His Thr 
    290                 295                 300                 


Glu His Thr Ser Tyr Ala Ala Asp Arg Phe Lys Gln Val Asp Gly Phe 
305                 310                 315                 320 


Tyr Ala Arg Asp Leu Thr Thr Lys Ala Arg Ala Thr Ser Pro Thr Thr 
                325                 330                 335     


Arg Asn Leu Leu Thr Thr Pro Lys Phe Thr Val Ala Trp Asp Trp Val 
            340                 345                 350         


Pro Lys Arg Pro Ala Val Cys Thr Met Thr Lys Trp Gln Glu Val Asp 
        355                 360                 365             


Glu Met Leu Arg Ala Glu Tyr Gly Gly Ser Phe Arg Phe Ser Ser Asp 
    370                 375                 380                 


Ala Ile Ser Thr Thr Phe Thr Thr Asn Leu Thr Gln Tyr Ser Leu Ser 
385                 390                 395                 400 


Arg Val Asp Leu Gly Asp Cys Ile Gly Arg Asp Ala Arg Glu Ala Ile 
                405                 410                 415     


Asp Arg Met Phe Ala Arg Lys Tyr Asn Ala Thr His Ile Lys Val Gly 
            420                 425                 430         


Gln Pro Gln Tyr Tyr Leu Ala Thr Gly Gly Phe Leu Ile Ala Tyr Gln 
        435                 440                 445             


Pro Leu Leu Ser Asn Thr Leu Ala Glu Leu Tyr Val Arg Glu Tyr Met 
    450                 455                 460                 


Arg Glu Gln Asp Arg Lys Pro Arg Asn Ala Thr Pro Ala Pro Leu Arg 
465                 470                 475                 480 


Glu Ala Pro Ser Ala Asn Ala Ser Val Glu Arg Ile Lys Thr Thr Ser 
                485                 490                 495     


Ser Ile Glu Phe Ala Arg Leu Gln Phe Thr Tyr Asn His Ile Gln Arg 
            500                 505                 510         


His Val Asn Asp Met Leu Gly Arg Ile Ala Val Ala Trp Cys Glu Leu 
        515                 520                 525             


Gln Asn His Glu Leu Thr Leu Trp Asn Glu Ala Arg Lys Leu Asn Pro 
    530                 535                 540                 


Asn Ala Ile Ala Ser Ala Thr Val Gly Arg Arg Val Ser Ala Arg Met 
545                 550                 555                 560 


Leu Gly Asp Val Met Ala Val Ser Thr Cys Val Pro Val Ala Pro Asp 
                565                 570                 575     


Asn Val Ile Val Gln Asn Ser Met Arg Val Ser Ser Arg Pro Gly Thr 
            580                 585                 590         


Cys Tyr Ser Arg Pro Leu Val Ser Phe Arg Tyr Glu Asp Gln Gly Pro 
        595                 600                 605             


Leu Ile Glu Gly Gln Leu Gly Glu Asn Asn Glu Leu Arg Leu Thr Arg 
    610                 615                 620                 


Asp Ala Leu Glu Pro Cys Thr Val Gly His Arg Arg Tyr Phe Ile Phe 
625                 630                 635                 640 


Gly Gly Gly Tyr Val Tyr Phe Glu Glu Tyr Ala Tyr Ser His Gln Leu 
                645                 650                 655     


Ser Arg Ala Asp Val Thr Thr Val Ser Thr Phe Ile Asp Leu Asn Ile 
            660                 665                 670         


Thr Met Leu Glu Asp His Glu Phe Val Pro Leu Glu Val Tyr Thr Arg 
        675                 680                 685             


His Glu Ile Lys Asp Ser Gly Leu Leu Asp Tyr Thr Glu Val Gln Arg 
    690                 695                 700                 


Arg Asn Gln Leu His Asp Leu Arg Phe Ala Asp Ile Asp Thr Val Ile 
705                 710                 715                 720 


Arg Ala Asp Ala Asn Ala Ala Met Phe Ala Gly Leu Cys Ala Phe Phe 
                725                 730                 735     


Glu Gly Met Gly Asp Leu Gly Arg Ala Val Gly Lys Val Val Met Gly 
            740                 745                 750         


Val Val Gly Gly Val Val Ser Ala Val Ser Gly Val Ser Ser Phe Met 
        755                 760                 765             


Ser Asn Pro Phe Gly Ala Leu Ala Val Gly Leu Leu Val Leu Ala Gly 
    770                 775                 780                 


Leu Val Ala Ala Phe Phe Ala Phe Arg Tyr Val Leu Gln Leu Gln Arg 
785                 790                 795                 800 


Asn Pro Met Lys Ala Leu Tyr Pro Leu Thr Thr Lys Glu Leu Lys Thr 
                805                 810                 815     


Ser Asp Pro Gly Gly Val Gly Gly Glu Gly Glu Glu Gly Ala Glu Gly 
            820                 825                 830         


Gly Gly Phe Asp Glu Ala Lys Leu Ala Glu Ala Arg Glu Met Ile Arg 
        835                 840                 845             


Tyr Met Ala Leu Val Ser Ala Met Glu Arg Thr Glu His Lys Ala Arg 
    850                 855                 860                 


Lys Lys Gly Thr Ser Ala Leu Leu Ser Ser Lys Val Thr Asn Met Val 
865                 870                 875                 880 


Leu Arg Lys Arg Asn Lys Ala Arg Tyr Ser Pro Leu His Asn Glu Asp 
                885                 890                 895     


Glu Ala Gly Asp Glu Asp Glu Leu 
            900                 


<210>  11
<211>  393
<212>  PRT
<213>  human herpesvirus 2

<400>  11

Met Gly Arg Leu Thr Ser Gly Val Gly Thr Ala Ala Leu Leu Val Val 
1               5                   10                  15      


Ala Val Gly Leu Arg Val Val Cys Ala Lys Tyr Ala Leu Ala Asp Pro 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu Pro 
        35                  40                  45              


Val Leu Asp Arg Leu Thr Asp Pro Pro Gly Val Lys Arg Val Tyr His 
    50                  55                  60                  


Ile Gln Pro Ser Leu Glu Asp Pro Phe Gln Pro Pro Ser Ile Pro Ile 
65                  70                  75                  80  


Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu 
                85                  90                  95      


His Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Asp Glu 
            100                 105                 110         


Ala Arg Lys His Thr Tyr Asn Leu Thr Ile Ala Trp Tyr Arg Met Gly 
        115                 120                 125             


Asp Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Pro 
    130                 135                 140                 


Tyr Asn Lys Ser Leu Gly Val Cys Pro Ile Arg Thr Gln Pro Arg Trp 
145                 150                 155                 160 


Ser Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe 
                165                 170                 175     


Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu 
            180                 185                 190         


Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His 
        195                 200                 205             


Arg Ala Arg Ala Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro 
    210                 215                 220                 


Ala Ala Cys Leu Thr Ser Lys Ala Tyr Gln Gln Gly Val Thr Val Asp 
225                 230                 235                 240 


Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val 
                245                 250                 255     


Ala Leu Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Pro Pro 
            260                 265                 270         


Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Asp Thr Thr Asn Ala 
        275                 280                 285             


Thr Gln Pro Glu Leu Val Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu 
    290                 295                 300                 


Glu Asp Pro Ala Gly Thr Val Ser Ser Gln Ile Pro Pro Asn Trp His 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Asp Val Ala Pro His His Ala Pro Ala Ala Pro 
                325                 330                 335     


Ser Asn Pro Gly Leu Ile Ile Gly Ala Leu Ala Gly Ser Thr Leu Ala 
            340                 345                 350         


Val Leu Val Ile Gly Gly Ile Ala Phe Trp Val Arg Arg Arg Ala Gln 
        355                 360                 365             


Met Ala Pro Lys Arg Leu Arg Leu Pro His Ile Arg Asp Asp Asp Ala 
    370                 375                 380                 


Pro Pro Ser His Gln Pro Leu Phe Tyr 
385                 390             


<210>  12
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  All uridine residues are 1-methyl-pseudouridine - encodes 
       glycoprotein D from Herpes Simplex Virus-2

<400>  12
ggaauaaaag ucucaacaca acauauacaa aacaaacgaa ucucaagcaa ucaagcauuc       60

uacuucuauu gcagcaauuu aaaucauuuc uuuuaaagca aaagcaauuu ucugaaaauu      120

uucaccauuu acgaacgaua gcaugacccg ccugaccgug cuggcccugc uggccggccu      180

gcuggccucc ucccgcgcca aguacgcccu ggccgacccc ucccugaaga uggccgaccc      240

caaccgcuuc cgcggcaaga accugcccgu gcuggaccag cugaccgacc cccccggcgu      300

gaagcgcgug uaccacaucc agcccucccu ggaggacccc uuccagcccc ccuccauccc      360

caucaccgug uacuacgccg ugcuggagcg cgccugccgc uccgugcugc ugcacgcccc      420

cuccgaggcc ccccagaucg ugcgcggcgc cuccgacgag gcccgcaagc acaccuacaa      480

ccugaccauc gccugguacc gcaugggcga caacugcgcc auccccauca ccgugaugga      540

guacaccgag ugccccuaca acaagucccu gggcgugugc cccauccgca cccagccccg      600

cugguccuac uacgacuccu ucuccgccgu guccgaggac aaccugggcu uccugaugca      660

cgcccccgcc uucgagaccg ccggcaccua ccugcgccug gugaagauca acgacuggac      720

cgagaucacc caguucaucc uggagcaccg cgcccgcgcc uccugcaagu acgcccugcc      780

ccugcgcauc ccccccgccg ccugccugac cuccaaggcc uaccagcagg gcgugaccgu      840

ggacuccauc ggcaugcugc cccgcuucau ccccgagaac cagcgcaccg uggcccugua      900

cucccugaag aucgccggcu ggcacggccc caagcccccc uacaccucca cccugcugcc      960

ccccgagcug uccgacacca ccaacgccac ccagcccgag cuggugcccg aggaccccga     1020

ggacuccgcc cugcuggagg accccgccgg caccgugucc ucccagaucc cccccaacug     1080

gcacaucccc uccauccagg acguggcccc ccaccacuaa cuaguaguga cugacuagga     1140

ucugguuacc acuaaaccag ccucaagaac acccgaaugg agucucuaag cuacauaaua     1200

ccaacuuaca cuuacaaaau guuguccccc aaaauguagc cauucguauc ugcuccuaau     1260

aaaaagaaag uuucuucaca uucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaac                                                                1386


<210>  13
<211>  1614
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  All uridine residues are 1-methyl-pseudouridine - encodes 
       glycoprotein E from Herpes Simplex Virus-2

<400>  13
ggaauaaaag ucucaacaca acauauacaa aacaaacgaa ucucaagcaa ucaagcauuc       60

uacuucuauu gcagcaauuu aaaucauuuc uuuuaaagca aaagcaauuu ucugaaaauu      120

uucaccauuu acgaacgaua gcaugcgcau gcagcugcug cugcugaucg cccugucccu      180

ggcccuggug accaacuccc gcaccuccug gaagcgcgug accuccggcg aggacguggu      240

gcugcugccc gcccccgccg gccccgagga gcgcacccgc gcccacaagc ugcugugggc      300

cgccgagccc cuggacgccu gcggcccccu gcgccccucc uggguggccc uguggccccc      360

ccgccgcgug cuggagaccg ugguggacgc cgccugcaug cgcgcccccg agccccuggc      420

caucgccuac uccccccccu uccccgccgg cgacgagggc cuguacuccg agcuggccug      480

gcgcgaccgc guggccgugg ugaacgaguc ccuggugauc uacggcgccc uggagaccga      540

cuccggccug uacacccugu ccgugguggg ccuguccgac gaggcccgcc agguggccuc      600

cguggugcug gugguggagc ccgcccccgu gcccaccccc acccccgacg acuacgacga      660

ggaggacgac gccggcgugu ccgagcgcac ccccgugucc gugccccccc ccaccccccc      720

ccgccgcccc cccguggccc cccccaccca cccccgcgug auccccgagg ugucccacgu      780

gcgcggcgug accgugcaca uggagacccc cgaggccauc cuguucgccc ccggcgagac      840

cuucggcacc aacgugucca uccacgccau cgcccacgac gacggccccu acgccaugga      900

cguggugugg augcgcuucg acgugcccuc cuccugcgcc gagaugcgca ucuacgaggc      960

cugccuguac cacccccagc ugcccgagug ccuguccccc gccgacgccc ccugcgccgu     1020

guccuccugg gccuaccgcc uggccgugcg cuccuacgcc ggcugcuccc gcaccacccc     1080

ccccccccgc ugcuucgccg aggcccgcau ggagcccgug cccggccugg ccuggcuggc     1140

cuccaccgug aaccuggagu uccagcacgc cuccccccag cacgccggcc uguaccugug     1200

cgugguguac guggacgacc acauccacgc cuggggccac augaccaucu ccaccgccgc     1260

ccaguaccgc aacgccgugg uggagcagca ccugccccag cgccagcccg agcccgugga     1320

gcccacccgc ccccacgugc gcgccuaacu aguagugacu gacuaggauc ugguuaccac     1380

uaaaccagcc ucaagaacac ccgaauggag ucucuaagcu acauaauacc aacuuacacu     1440

uacaaaaugu ugucccccaa aauguagcca uucguaucug cuccuaauaa aaagaaaguu     1500

ucuucacauu cuaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaac           1614


<210>  14
<211>  1470
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  UL48 of HSV-2 RNA sequence

<400>  14
auggaucugc ugguggauga ucuguuugcg gaugcggaug gcgugagccc gccgccgccg       60

cgcccggcgg gcggcccgaa aaacaccccg gcggcgccgc cgcuguaugc gaccggccgc      120

cugagccagg cgcagcugau gccgagcccg ccgaugccgg ugccgccggc ggcgcuguuu      180

aaccgccugc uggaugaucu gggcuuuagc gcgggcccgg cgcugugcac caugcuggau      240

accuggaacg aagaucuguu uagcggcuuu ccgaccaacg cggauaugua ucgcgaaugc      300

aaauuucuga gcacccugcc gagcgaugug auugauuggg gcgaugcgca ugugccggaa      360

cgcagcccga uugauauucg cgcgcauggc gauguggcgu uuccgacccu gccggcgacc      420

cgcgaugaac ugccgagcua uuaugaagcg auggcgcagu uuuuucgcgg cgaacugcgc      480

gcgcgcgaag aaagcuaucg caccgugcug gcgaacuuuu gcagcgcgcu guaucgcuau      540

cugcgcgcga gcgugcgcca gcugcaucgc caggcgcaua ugcgcggccg caaccgcgau      600

cugcgcgaaa ugcugcgcac caccauugcg gaucgcuauu aucgcgaaac cgcgcgccug      660

gcgcgcgugc uguuucugca ucuguaucug uuucugagcc gcgaaauucu gugggcggcg      720

uaugcggaac agaugaugcg cccggaucug uuugauggcc ugugcugcga ucuggaaagc      780

uggcgccagc uggcgugccu guuucagccg cugauguuua uuaacggcag ccugaccgug      840

cgcggcgugc cgguggaagc gcgccgccug cgcgaacuga accauauucg cgaacaucug      900

aaccugccgc uggugcgcag cgcggcggcg gaagaaccgg gcgcgccgcu gaccaccccg      960

ccggugcugc agggcaacca ggcgcgcagc agcggcuauu uuaugcugcu gauucgcgcg     1020

aaacuggaua gcuauagcag cguggcgacc agcgaaggcg aaagcgugau gcgcgaacau     1080

gcguauagcc gcggccgcac ccgcaacaac uauggcagca ccauugaagg ccugcuggau     1140

cugccggaug augaugaugc gccggcggaa gcgggccugg uggcgccgcg caugagcuuu     1200

cugagcgcgg gccagcgccc gcgccgccug agcaccaccg cgccgauuac cgaugugagc     1260

cugggcgaug aacugcgccu ggauggcgaa gaaguggaua ugaccccggc ggaugcgcug     1320

gaugauuuug aucuggaaau gcugggcgau guggaaagcc cgagcccggg caugacccau     1380

gauccgguga gcuauggcgc gcuggaugug gaugauuuug aauuugaaca gauguuuacc     1440

gaugcgaugg gcauugauga uuuuggcggc                                      1470


<210>  15
<211>  906
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  UL49 of HSV-2 RNA sequence

<400>  15
augaccucuc gccgcuccgu caagucgugu ccgcgggaag cgccgcgcgg gacccacgag       60

gagcuguacu auggcccggu cuccccggcg gauccagaga guccgcgcga cgacuuccgc      120

cgcggcgcug gcccgaugcg cgcgcgccca aggggcgagg uucgcuuucu ccauuaugac      180

gaggcugggu augcccucua ccgggacucg ucgucguccg aagacaacga cgagucccgg      240

gauaccgcgc gaccgcgucg uucggcgucc gucgcgggcu cucacggccc cggccccgcg      300

cgcgcuccuc caccccccgg gggccccgug ggcgccggcg ggcgcucgca cgccccuccc      360

gcgcggaccc ccaaaaugac gcgcggggcg ccuaaggccc ccgcgacccc ggcgaccgac      420

ccugcccgcg gcaggcgacc cgcccaggcc gacuccgccg ugcuccuaga cgcccccgcu      480

cccacggccu cgggaagaac caagacaccc gcccagggac uggccaagaa gcugcacuuc      540

agcaccgccc caccgagccc cacggcgccg uggacccccc ggguggccgg guucaacaag      600

cgcgucuucu gcgccgcggu cgggcgccug gcggccacgc acgcccggcu ggcggcggua      660

cagcuguggg acaugucgcg gccgcacacc gacgaagacc ucaacgagcu ccucgaccuc      720

accaccauuc gcgugacggu cugcgagggc aagaaccucc ugcagcgcgc gaacgaguug      780

gugaaucccg acgcggcgca ggacgucgac gcgaccgcgg ccgcccgggg ccgccccgcg      840

gggcgugccg ccgcgaccgc acgggccccc gcccgcucgg cuucccgucc ccgccgcccc      900

cucgag                                                                 906


<210>  16
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  UL11 of HSV-2 RNA sequence

<400>  16
augggccucg cguucuccgg ggcgcggccc ugcugcugcc gacacaacgu caucaucacc       60

gacggcgggg aggucgucuc gcugaccgcc cacgaauuug acgucgugga caucgagucc      120

gaagaagagg guaacuucua cgugcccccc gacaugcgcg uggucacccg ggcgccgggg      180

ccccaguacc ggcgcgcauc ggacccccca ucgcgucaca ccagacggcg ggaccccgac      240

guggcccgcc cuccugccac gcucacgccc ccacucucug acagcgaaua a               291


<210>  17
<211>  1119
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  UL16 of HSV-2 RNA sequen

<400>  17
auggcacagc gggcacucug gcguccccag gcgacgccag gccccccggg agccgcggcc       60

ccgccggguc accggggcgc cccccccgac gcgcgcgccc ccgacccggg gcccgaagcc      120

gaccucgucg cgcgcaucgc caacucuguc uucguguggc gcgucguucg gggggacgag      180

cggcuuaaga uuuuucggug ccucacgguc cucaccgagc cgcugugcca gguggcccuu      240

ccggaccccg accccgagcg ugcccuuuuc ugcgagaucu uccuguaccu gacgcggccc      300

aaggcgcugc gccugccuuc gaacacguuc uuugccauuu ucuucuuuaa ccgcgagcgc      360

cgcuacugcg ccaccgucca ccuccgcagc guaacgcacc cccggacccc gcugcugugc      420

acccuagccu ucggccaccu ggaagcugcc ucccccccgg aggaaacccc cgaccccgcc      480

gccgaacagc ucgcggacga gcccguggcc cacgagcucg acggcgccua ccugguaccc      540

acggaaccgc ccccgaaucc gggggcgugc ugugcccugg guccgggggc cugguggcac      600

cuccccggcg gccgcauaua cugcugggcc auggaugaug accugggguc gcucuguccc      660

ccgggcagcc gggcccgcca uuuaggaugg cugcuaucca ggauuaccga ccccccggga      720

ggaggcggcg ccugcgcccc gacggcccac aucgauuccg ccaacgcgcu guggcgcgcc      780

cccgccgugg cggaggccug ucccugcguc gccccgugca ugugguccaa uauggcccag      840

cgcacccugg ccguccgggg ggacgcgagc cugugucagc uccucuucgg gcaccccgug      900

gacgcgguua uccugcggca ggcgacccgc cgcccgcgca ucacggccca ccugcacgag      960

gucgucgugg gccgggacgg cgcggaaagc gucauccgcc cgaccagcgc cggguggcgc     1020

cucugcguuc ugucaucgua uaccagccgc cuguuugcaa cgagcugccc cgcggucgcg     1080

cgggccgugg ccagagccuc aucguccgau uacaaauaa                            1119


<210>  18
<211>  1599
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  UL21 of HSV-2 RNA sequence

<400>  18
auggagcuca gcuaugccac cacccugcac caccgggacg uuguguuuua cgucacggca       60

gacagaaacc gcgccuacuu ugugugcggg ggguccguuu auuccguagg gcggccucgg      120

gauucucagc cgggggaaau ugccaaguuu ggccuggugg uccgggggac aggccccaaa      180

gaccgcaugg ucgccaacua cguacgaagc gagcuccgcc agcgcggccu gcgggacgug      240

cggcccgugg gggaggacga gguguuccug gacagcgugu gucugcuaaa cccgaacgug      300

agcuccgagc gagacgugau uaauaccaac gacguugaag ugcuggacga augccuggcc      360

gaauacugca ccucgcugcg aaccagcccg ggggugcugg ugaccggggu gcgcgugcgc      420

gcgcgagaca gggucaucga gcuauuugag cacccggcga ucgucaacau uuccucgcgc      480

uucgcguaca cccccucccc cuacguauuc gcccuggccc aggcgcaccu cccccggcuc      540

ccgagcucgc uggagccccu ggugagcggc cuguuugacg gcauucccgc cccgcgccag      600

ccccuggacg cccgcgaccg gcgcacggau gucgugauca cgggcacccg cgcccccaga      660

ccgauggccg ggaccggggc cgggggcgcg ggggccaagc gggccaccgu cagcgaguuc      720

gugcaaguga agcacaucga ccguguugug uccccgagcg ucucuuccgc ccccccgccg      780

agcgcccccg acgcgagucu gccgcccccg gggcuccagg aggccgcccc gccgggcccc      840

ccgcucaggg agcuguggug gguguucuac gccggcgacc gggcgcugga ggagccccac      900

gccgagucgg gauugacgcg cgaggagguc cgcgccgugc auggguuccg ggagcaggcg      960

uggaagcugu uugggucggu gggggcuccg cgggcguuuc ucggggccgc gcuggcccug     1020

agcccgaccc aaaagcucgc cgucuacuac uaucucaucc accgggagcg gcgcaugucc     1080

cccuuccccg cgcucgugcg gcucgucggu cgguacaucc agcgccacgg ccuguacguu     1140

cccgcgcccg acgaaccgac guuggccgau gccaugaacg ggcuguuccg cgacgcgcug     1200

gcggccggga ccguggccga gcagcuccuc auguucgacc uccucccgcc caaggacgug     1260

ccggugggga gcgacgcgcg ggccgacagc gccgcccugc ugcgcuuugu ggacucgcaa     1320

cgccugaccc cggggggguc cgucucgccc gagcacguca uguaccucgg cgcguuccug     1380

ggcguguugu acgccggcca cggacgccug gccgcggcca cgcauaccgc gcgccugacg     1440

ggcgugacgu cccugguccu gaccgugggg gacgucgacc ggauguccgc guuugaccgc     1500

gggccggcgg gggcggcugg ccgcacgcga accgccgggu accuggacgc gcugcuuacc     1560

guuugccugg cucgcgccca gcacggccag ucuguguga                            1599


<210>  19
<211>  918
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  UL31 of HSV-2 RNA sequence

<400>  19
auguaugaca ucgccccccg ucgcuccggc ucccggcccg ggcccggccg cgacaagacc       60

cggcggcggu cgcgcuuuuc cgccgccggg aaccccggcg uggagcgccg ggccucccgc      120

aagagccugc cgucgcacgc gcgcaggcug gagcucugcc ugcacgagcg ccgucgcuac      180

cgcggcuucu ucgccgcccu cgcccagacg cccuccgagg agaucgccau cgugcgcucg      240

cucuccgugc cccuggugaa gacgaccccc gugucgcucc ccuucagccu ggaccagacc      300

guggccgaca acugccugac ccucucgggc augggcuacu accuggggau cgggggcugc      360

ugccccgcgu gcagcgcggg cgacgggcgg cuggccaccg ucagccgcga ggcccucauc      420

cuggccuucg ugcagcagau caauacgauc uuugagcacc gcaccuuucu ggccucccug      480

gucgugcugg ccgaccgcca cagcaccccc cuccaggacc uccuggccga uacgcucggc      540

cagcccgagc ucuuuuucgu gcacacgauc cugcgcggag ggggggcgug cgacccccgg      600

uuucuuuuuu acccggaccc cacguacggg ggccacaugc uguacgucau cuuccccggc      660

acgucggccc accugcacua ccggcucauc gaucggaugc ugaccgcgug ccccggcuac      720

cgguucgccg cccacgugug gcagagcacg uuugugcucg uggucagacg caacgcagag      780

aaaccagcgg acgcggaaau uccgaccgug ucggccgcag acauuuauug caagaugcgg      840

gacaucagcu ucgacggggg gcucaugcua gaguaucaaa ggcucuaugc aacauucgac      900

gaguuuccuc cgccguag                                                    918


<210>  20
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  UL34 of HSV-2 RNA sequence

<400>  20
auggcgggga uggggaagcc cuacggcggc cgcccggggg acgcguucga gggucucguu       60

cagcgcauca ggcucauugu ucccaccacg cugcgcggcg ggggugggga gucgggcccc      120

uacucgccau ccaacccgcc cucgagaugu gccuuccagu uccacggcca ggaugggucc      180

gacgaggccu ucccgaucga guacguccug cggcucauga acgacugggc cgaugugccc      240

ugcaaccccu accugcgcgu gcagaacacc ggcguuucgg ugcuguuuca gggguuuuuu      300

aaccggcccc acggcgcccc ggggggcgcg aucacggcgg agcagaccaa cgugauucug      360

cacuccaccg agacgacggg acugucccuc ggagaccugg acgacgucaa ggggcgccuc      420

ggccuggacg cccggccgau gauggccagc auguggauca gcugcuuugu gcgcaugccc      480

cgggugcagc ucgcguuucg guucaugggc cccgaggacg ccguucgcac gcggcggauc      540

cugugucgcg ccgccgagca ggcccucgcc cgucgccgcc gguccaggcg gucccaggau      600

gacuacgggg cgguggcggu ggcggcggcg caccacucuu ccggagcgcc cgggccgggg      660

gucgccgccu cgggcccgcc agcgccgccc ggacggggac cggcccgucc guggcaucag      720

gccgugcagu uguuccgggc cccgcguccg uga                                   753


<210>  21
<211>  321
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Cytoplasmic tail of gE protein of HSV-2 RNA sequence

<400>  21
cgcaggcgcu ccuggcgggc gguuaaaagc cgggccucgg cgacgggccc cacuuacauu       60

cgcguggcgg acagcgagcu guacgcggac uggaguucgg acagcgaggg ggagcgcgac      120

gggucccugu ggcaggaccc uccggagaga cccgacucuc ccuccacaaa uggauccggc      180

uuugagaucu uaucaccaac ggcuccgucu guauaccccc auagcgaggg gcguaaaucu      240

cgccgcccgc ucaccaccuu ugguucggga agcccgggcc gucgucacuc ccaggccucc      300

uauucguccg uccucuggua a                                                321


<210>  22
<211>  1182
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gD of HSV-2 RNA sequence

<400>  22
auggggcguu ugaccuccgg cgucgggacg gcggcccugc uaguugucgc ggugggacuc       60

cgcgucgucu gcgccaaaua cgccuuagca gaccccucgc uuaagauggc cgaucccaau      120

cgauuucgcg ggaagaaccu uccgguuuug gaccagcuga ccgacccccc cggggugaag      180

cguguuuacc acauucagcc gagccuggag gacccguucc agccccccag caucccgauc      240

acuguguacu acgcagugcu ggaacgugcc ugccgcagcg ugcuccuaca ugccccaucg      300

gaggcccccc agaucgugcg cggggcuucg gacgaggccc gaaagcacac guacaaccug      360

accaucgccu gguaucgcau gggagacaau ugcgcuaucc ccaucacggu uauggaauac      420

accgagugcc ccuacaacaa gucguugggg gucugcccca uccgaacgca gccccgcugg      480

agcuacuaug acagcuuuag cgccgucagc gaggauaacc ugggauuccu gaugcacgcc      540

cccgccuucg agaccgcggg uacguaccug cggcuaguga agauaaacga cuggacggag      600

aucacacaau uuauccugga gcaccgggcc cgcgccuccu gcaaguacgc ucucccccug      660

cgcauccccc cggcagcgug ccucaccucg aaggccuacc aacagggcgu gacggucgac      720

agcaucggga uguuaccccg cuuuaucccc gaaaaccagc gcaccgucgc ccuauacagc      780

uuaaaaaucg ccggguggca cggccccaag cccccguaca ccagcacccu gcugccgccg      840

gagcuguccg acaccaccaa cgccacgcaa cccgaacucg uuccggaaga ccccgaggac      900

ucggcccucu uagaggaucc cgccgggacg gugucuucgc agaucccccc aaacuggcac      960

aucccgucga uccaggacgu cgcgccgcac cacgcccccg ccgcccccag caacccgggc     1020

cugaucaucg gcgcgcuggc cggcaguacc cuggcggcgc uggucaucgg cgguauugcg     1080

uuuuggguac gccgccgcgc ucagauggcc cccaagcgcc uacgucuccc ccacauccgg     1140

gaugacgacg cgccccccuc gcaccagcca uuguuuuacu ag                        1182


<210>  23
<211>  2192
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gB of HSV-2 RNA sequence

<400>  23
augcgcggug gcggauugau cugcgcccug guggugggug cacugguggc ugcugucgcu       60

ucagcugcuc cugcugcucc ugcagcuccu cgcgcuagug guggcguugc ugccaccgug      120

gcagcgaacg gagguccagc uagccguccu cccccagucc cgucuccugc aaccacuaag      180

gcacgcaagc guaaaaccaa gaaaccgccu aagaggccug aagcaacucc cccaccggac      240

gcaaacgcua cuguggcugc uggucacgcu acucucaggg cucauuugag agagaucaag      300

guugaaaacg cugacgccca guucuacgug ugcccucccc caacaggugc aacuguugug      360

caguucgaac agccucgcag guguccuacc aggccugagg gucaaaacua cacugaaggc      420

aucgcugucg uuuucaagga gaacauugcc ccauacaagu ucaaagcaac cauguacuac      480

aaagacguga cugucucgca agugugguuc ggacaccguu acucccaauu cauggguauc      540

uucgaggaca gggcucccgu uccauucgag gaagugaucg auaagauuaa cgccaaaggc      600

gugugcaggu ccacagcaaa guacgucaga aacaacaugg agacaacggc uuuccaccgc      660

gacgaucaug agaccgacau ggaauugaag ccugcgaaag uggcuacaag gacgucgaga      720

ggcuggcaca ccacugaucu gaaguacaac cccuccaggg uugaagccuu ccauagauac      780

ggaacaacgg ugaacuguau cguugaggaa guggaugccc gcucagugua ccccuacgac      840

gaguucgucc uggcuaccgg agauuucguu uacaugaguc cauucuacgg auacagggag      900

gguucgcaca ccgaacauac uuccuacgca gcggacagau ucaagcaggu ggaugguuuc      960

uacgcucgcg accugaccac uaaagcacgu gcgacuucuc cuacaacgag gaaccugcuc     1020

accacuccca aguucacagu cgcuugggac uggguuccaa agaggccggc cgucugcacc     1080

augacuaaau ggcaggaggu ugacgaaaug cugagagcug aauacggcgg aagcuuccgc     1140

uucuccagcg augccaucuc uacaacguuc accacuaacc ugacucaaua cucccucagc     1200

cguguggacc ugggugacug uaucggacgc gaugcccgug aggcaauuga ccgcauguuc     1260

gcgcguaagu acaacgcuac acacaucaaa gugggccagc cacaauacua ccucgcgacg     1320

gguggcuucu ugauugcuua ccagccuuug cugucaaaca cucucgcuga auuguacguc     1380

agggaguaca ugagagaaca agacaggaag ccaagaaacg cgacaccggc uccucugaga     1440

gaggcuccgu cugcuaacgc cucaguggaa cgcaucaaga caaccuccuc cauugaguuc     1500

gcucgucucc aguucaccua caaccacauc caacgucaug ugaacgacau gcugggaagg     1560

auugcagucg cguggugcga gcuccagaac cacgaacuga cccucuggaa cgaggccagg     1620

aagcucaacc caaacgcuau cgccucagca acugucggca ggagaguuag ugcgagaaug     1680

uugggagacg ucauggcugu uagcaccugc guuccugugg cccccgauaa cgucauuguu     1740

caaaacucua ugcgcgucag uucgcgucca ggaacuuguu acucccgccc gcucguuagc     1800

uuccguuacg aggaccaggg uccacugauc gaaggucaac ucggcgagaa caacgaauug     1860

cgccugacac gugaugcucu ggagccuugu acggucgguc accgccguua cuucauuuuc     1920

ggagguggcu acguguacuu cgaggaauac gcauacaguc accaguuguc gcgcgcugac     1980

gugaccacug ucuccacauu caucgacuug aacauuacga ugcuggagga ucacgaauuc     2040

gugccccugg gugucuacac acgucaugaa aucaaggaca gcggccucuu ggauuacacc     2100

gagguccaga ggagaaacca acugcacgac cucagauucg cugacaucga uacugugauu     2160

cgcgcggaug cuaacgcugc cauguucgcu gg                                   2192


<210>  24
<211>  1251
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gE of HSV-2 RNA sequence

<400>  24
auggccaggg gcgccggccu gguguucuuc gugggcgugu ggguggugag cugccuggcc       60

gccgccccca ggaccagcug gaagagggug accagcggcg aggacguggu gcugcugccc      120

gcccccgccg gccccgagga gaggaccagg gcccacaagc ugcugugggc cgccgagccc      180

cuggacgccu gcggcccccu gaggcccagc uggguggccc uguggccccc caggagggug      240

cuggagaccg ugguggacgc cgccugcaug agggcccccg agccccuggc caucgccuac      300

agcccccccu uccccgccgg cgacgagggc cuguacagcg agcuggccug gagggacagg      360

guggccgugg ugaacgagag ccuggugauc uacggcgccc uggagaccga cagcggccug      420

uacacccuga gcgugguggg ccugagcgac gaggccaggc agguggccag cguggugcug      480

gugguggagc ccgcccccgu gcccaccccc acccccgacg acuacgacga ggaggacgac      540

gccggcguga gcgagaggac ccccgugagc gugccccccc ccaccccccc caggaggccc      600

cccguggccc cccccaccca ccccagggug auccccgagg ugagccacgu gaggggcgug      660

accgugcaca uggagacccc cgaggccauc cuguucgccc ccggcgagac cuucggcacc      720

aacgugagca uccacgccau cgcccacgac gacggccccu acgccaugga cguggugugg      780

augagguucg acgugcccag cagcugcgcc gagaugagga ucuacgaggc cugccuguac      840

cacccccagc ugcccgagug ccugagcccc gccgacgccc ccugcgccgu gagcagcugg      900

gccuacaggc uggccgugag gagcuacgcc ggcugcagca ggaccacccc cccccccagg      960

ugcuucgccg aggccaggau ggagcccgug cccggccugg ccuggcuggc cagcaccgug     1020

aaccuggagu uccagcacgc cagcccccag cacgccggcc uguaccugug cgugguguac     1080

guggacgacc acauccacgc cuggggccac augaccauca gcaccgccgc ccaguacagg     1140

aacgccgugg uggagcagca ccugccccag aggcagcccg agcccgugga gcccaccagg     1200

ccccacguga gggccccccc ccccgccccc agcgccaggg gcccccugag g              1251


<210>  25
<211>  1692
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized UL48 of HSV-2 RNA sequence including UTRs and 
       polyA, all uridine residues are 1-methyl-pseudouridine

<400>  25
uaauacgacu cacuauaagg acucacuauu uguuuucgcg cccaguugca aaaagugucg       60

ucaccaugga ccugcucguu gacgauuugu ucgcugacgc agauggugug agcccucccc      120

caccgaggcc agcugguggc ccuaagaaca ccccugcugc cccuccccug uacgcaacug      180

gcagauuguc acaggcgcaa cugaugccua guccaccgau gccugugccu cccgcagcuc      240

ucuucaacag guugcuggac gauuugggcu ucagcgcagg acccgcguug ugcacaaugc      300

uggauacgug gaacgaggac cuguucucug gcuuccccac aaacgcagac auguaccgcg      360

aguguaaauu ccugucuacg cucccaucag acgucaucga uuggggcgac gcccacguuc      420

ccgaaagguc uccaaucgac auuagagcac auggagaugu cgcguuccca acccugccgg      480

cuacucgcga cgagcuccca ucauacuacg aagcgauggc ucaguucuuc aggggagagu      540

ugcgcgcccg ugaagaaagu uacagaacag ugcuggcuaa cuucugcucg gcccucuacc      600

gcuacuugcg ugcauccguc aggcagcugc acagacaagc gcauaugagg gguagaaacc      660

gcgaccugcg cgaaaugcuc cguaccacua ucgcugauag guacuacaga gagacugcuc      720

gccuggcccg ugucuuguuc cugcaccucu acuuguuccu gucacgcgaa auucucuggg      780

cugccuacgc cgagcaaaug augcguccag auuuguucga cggccugugc ugugaccucg      840

agucguggcg ccaguuggcu ugucuguucc aaccauugau guucaucaac ggaucccuga      900

ccguucgugg ugugccugug gaggcacgcc gucuccgcga auugaaccac auucgugagc      960

aucucaacuu gccucugguu cguucugcag cugcugagga accuggagcu ccccucacaa     1020

cgccaccggu guugcagggc aaccaagccc gcuccagcgg auacuucaug cucuugaucc     1080

gugcuaagcu ggacuccuac ucuucagugg ccaccuccga gggugaaucg gucaugcgcg     1140

aacacgcuua cucacguggc aggacaagaa acaacuacgg uaguacgauu gaaggccugc     1200

ucgaccugcc cgacgaugac gaugcaccag cagaggcugg acugguggcu ccucgcaugu     1260

ccuuccucag cgccggucag agaccgagga gacucagcac cacugccccc aucaccgaug     1320

ucucuuuggg ugacgagcuc cguuuggaug gcgaggaagu ugacaugacu ccugcugaug     1380

cccucgacga uuucgaccug gaaaugcucg gagaugucga gaguccuucg cccgguauga     1440

cacacgaccc cguuuccuac ggugcucugg auguggacga uuucgaguuc gaacaaaugu     1500

ucacggacgc aaugggcauc gacgauuucg gagguggcgc gggauccgga gguggcggaa     1560

gcgguggcgg agguucucac caccaucauc accaucacca uuaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa aa                                                         1692


<210>  26
<211>  607
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized UL11 of HSV-2 RNA sequence including UTRs and 
       polyA, all uridine residues are 1-methyl-pseudouridine

<400>  26
uaauacgacu cacuauaagg acucacuauu uguuuucgcg cccaguugca aaaagugucg       60

ucaccauggg uuuggcuuuu aguggagcua ggccuuguug uuguaggcau aaugugauua      120

uuacugaugg uggcgaagug gugucacuca cugcucauga guucgauguu guugauauag      180

aaagugagga agaagggaau uucuaugucc cgccagauau gcggguagug acuagagccc      240

ccggcccaca auauagaaga gccagcgauc cacccucucg acauacucga cgacgagauc      300

cagauguagc acggccccca gcgaccuuga ccccaccccu guccgauucc gagugagaga      360

gcucgcuuuc uugcugucca auuucuauua aagguuccuu uguucccuaa guccaacuac      420

uaaacugggg gauauuauga agggccuuga gcaucuggau ucugccuaau aaaaaacauu      480

uauuuucauu gcugcgucca aucaaccucu ggauuacaaa aaaaaaaaaa aaaaaaaaaa      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaaaaa                                                                607


<210>  27
<211>  1435
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized UL16 of HSV-2 RNA sequence including UTRs and 
       polyA, all uridine residues are 1-methyl-pseudouridine

<400>  27
uaauacgacu cacuauaagg acucacuauu uguuuucgcg cccaguugca aaaagugucg       60

ucaccauggc ucaaagagcc cuguggagac cacaagccac cccuggacca cccggcgcug      120

ccgcuccacc uggacauaga ggugcucccc cagaugcuag agcuccugau ccagguccgg      180

aagcagauuu gguugccaga auugcgaaua gcguguuugu cuggagaguu gugcgcggug      240

augaaaggcu gaaaaucuuc cgcugucuga cuguacuuac ggaacccuua ugucaagucg      300

cauuacccga uccugauccu gaaagagcuc uguuuuguga aaucuuucug uaucucaccc      360

gcccgaaagc ucuccggcuc ccgucuaaua ccuucuucgc gaucuucuuc uucaauagag      420

aaaggcggua uugugcaaca gugcaucuuc ggucuguuac ccauccgaga acaccacucc      480

ucuguacacu ggcuuuugga caucucgagg cggcuucucc acccgaagag acuccugauc      540

cagcagcuga gcaacuggca gaugaaccag uugcacauga acuugauggg gcauaucucg      600

uuccaacuga gccaccacca aacccaggug ccuguugcgc guugggacca ggagcuuggu      660

ggcaucugcc aggugggcgg aucuauuguu gggcuaugga cgacgaucuc gguagucugu      720

gcccacccgg gagucgugcu agacaccucg gcuggcuucu uucacgcauc acggauccac      780

ccgggggggg cggggcaugu gcucccacag cucauauuga cagugcuaau gcccuuuggc      840

gagcuccagc aguugcugaa gcuugcccgu guguggcucc uuguaugugg agcaacaugg      900

cgcaacggac acuugcugug cgcggugaug ccucacucug ccaauugcug uuuggucauc      960

cugucgaugc ugugauacuu cgucaagcca cuagacgucc caggauuaca gcacaucucc     1020

augaaguggu gguaggaagg gauggagcag agagugugau uaggcccacg uccgcuggcu     1080

ggagacugug uguguuaagc uccuacacaa guaggcuuuu cgcuacuagu uguccggccg     1140

uugcaagagc ugucgcaagg gcauccaguu cugacuauaa guaggagagc ucgcuuucuu     1200

gcuguccaau uucuauuaaa gguuccuuug uucccuaagu ccaacuacua aacuggggga     1260

uauuaugaag ggccuugagc aucuggauuc ugccuaauaa aaaacauuua uuuucauugc     1320

ugcguccaau caaccucugg auuacaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa          1435


<210>  28
<211>  1915
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized UL21 of HSV-2 RNA sequence including UTRs and 
       polyA, all uridine residues are 1-methyl-pseudouridine

<400>  28
uaauacgacu cacuauaagg acucacuauu uguuuucgcg cccaguugca aaaagugucg       60

ucaccaugga acuguccuac gcaacaacuc uucaucauag agauguaguc uucuauguga      120

ccgccgaucg gaauagggca uauuucgucu guggcgguag ugucuacucu gugggcagac      180

cgagggacag ccaaccuggc gagaucgcua aauucgggcu cgucgugagg gguaccggac      240

caaaggauag aaugguggca aauuaugugc gguccgaauu gaggcaaaga ggucuccgcg      300

auguuagacc uguuggcgaa gaugaaguau uucucgauuc cguuugcuug uugaauccaa      360

auguuuccuc agaacgcgau guaaucaaca cuaaugaugu cgaggucuug gaugaguguc      420

ucgcugagua uuguacaagc cucaggacga gucccggugu uuuagucaca ggaguuaggg      480

ucagagcacg cgauagagug auugaauuau ucgaacaucc cgcuauugua aauaucucua      540

gccgauuugc auauacgccu ucuccauaug uguuugcucu cgcucaagcc caucugccac      600

gucugccauc cucacucgaa ccgcucguau cuggguuguu cgaugggaua ccggcaccaa      660

gacaaccgcu cgaugcucga gaucgccgua ccgauguggu uauaaccggg acaagagcac      720

cacggccuau ggcgggaaca ggcgcaggcg gagccggcgc uaaacgcgcu acaguguccg      780

aauuuguaca ggucaaacau auagauagag uggucucacc uaguguaagc agugcgccac      840

ccccuagugc gccugaugcu ucacuucccc cgcccggacu gcaagaagcg gcaccaccag      900

gaccaccccu gagagaauua uggugggucu uuuaugcugg agauagggcu cuugaagaac      960

cucaugcaga aagcggccug accagggaag aagugagggc uguccacggu uuuagagaac     1020

aagccuggaa auuauucggc ucuguuggag cccccagggc cuuccugggc gcagcauuag     1080

cacucucucc cacacagaaa cuggcagugu auuauuacuu gauacaucgc gaaaggagaa     1140

ugucuccguu uccggcccuu guacgcuugg ugggaagaua uauucaaagg cauggacucu     1200

augugccugc cccagaugag cccacccucg cugacgcuau gaauggucug uuucgggaug     1260

cucuugcugc aggcacaguu gcagaacaac uguuaauguu ugauuuguua cccccuaaag     1320

auguaccagu uggaucugau gcaagagcug auagugcugc acuccucaga uucgucgaua     1380

gccagcggcu cacacccggu ggcagcguga gcccagaaca ugugauguau cucggggcau     1440

uucuuggugu ucuuuaugcu gggcauggca gacuugcugc cgcgacucac acugcucggu     1500

ugacaggugu aacaagccuc guuuugacag uuggcgaugu agauaggaug ucagccuucg     1560

aucgaggucc agccggcgca gcaggacgaa cuagaacugc aggauaucuc gaugcucucu     1620

uaacagugug ucuugcccgg gcucaacaug ggcaauccgu uuaggagagc ucgcuuucuu     1680

gcuguccaau uucuauuaaa gguuccuuug uucccuaagu ccaacuacua aacuggggga     1740

uauuaugaag ggccuugagc aucuggauuc ugccuaauaa aaaacauuua uuuucauugc     1800

ugcguccaau caaccucugg auuacaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa          1915


<210>  29
<211>  1339
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized gD of HSV-2 RNA sequence including UTRs and 
       polyA, all uridine residues are 1-methyl-pseudouridine

<400>  29
uaauacgacu cacuauaagg acucacuauu uguuuucgcg cccaguugca aaaagugucg       60

ucaccauggg ccgccucacu agugggguug guacugcugc guuacugguc guggcugucg      120

ggcuuagagu gguuugugcu aaguaugcac uugcugaucc aucacugaaa auggcagacc      180

caaaccgcuu cagggguaag aauuugcccg ugcuggauca auugacagau ccaccgggcg      240

uuaaaagagu cuaucauauc caacccaguc ucgaagaucc uuuucaaccc ccuuccauuc      300

ccauuaccgu auauuaugcc guauuagagc gggcuugucg uuccguacuu uugcacgcgc      360

cauccgaagc accucaaauu gucagaggag cauccgauga agcuagaaaa cauaccuaua      420

aucucacaau agcuugguac agaaugggcg auaacugugc cauuccaauu acagucaugg      480

aguauacgga auguccuuau aauaaaaguc ucggaguaug uccaauuaga acccaaccac      540

gguggucaua uuacgauucc uucagugcgg uuucugaaga caaucucggg uuucucaugc      600

augcuccagc uuuugaaacu gcaggcacau aucuuagacu gguuaaaauu aaugauugga      660

ccgaaauaac ccaguucauu uuggaacauc gagcuagggc aagcuguaaa uaugcccugc      720

cucuccggau uccaccugcc gcuuguuuga cuagcaaagc uuaucagcaa ggaguaaccg      780

uagauucuau ugguaugcug ccuagguuca uuccagagaa ucaacggacu guugcucucu      840

auucccugaa gauugcggga uggcaugggc cuaaaccacc cuauacauca acucuuuuac      900

cgcccgaacu cucugauacg acaaaugcua cacagccaga gcuggugccc gaggauccag      960

aagauagugc ucugcuggaa gacccggcug gcacagucuc cagccaaauu ccacccaauu     1020

ggcauauucc cucaauucaa gauguggccc cucaucaugc uccugcugca ccgaguaauc     1080

cagguugaga gagcucgcuu ucuugcuguc caauuucuau uaaagguucc uuuguucccu     1140

aaguccaacu acuaaacugg gggauauuau gaagggccuu gagcaucugg auucugccua     1200

auaaaaaaca uuuauuuuca uugcugcguc caaucaaccu cuggauuaca aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1320

aaaaaaaaaa aaaaaaaaa                                                  1339


<210>  30
<211>  1474
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized ICP4 of HSV-2 RNA sequence including UTRs and 
       polyA, all uridine residues are 1-methyl-pseudouridine

<400>  30
uaauacgacu cacuauaagg acucacuauu uguuuucgcg cccaguugca aaaagugucg       60

ucaccauggc aguucgcaga gcuggccggc aaccaccucg cccucuuggc ggugccagag      120

gcggcggcgg ugccgguccu guaagagguc ugggucggcc uggagccaga guaggggcua      180

gagcaggccg cagaggagcg gcuguaagac ccgaccaugc agcggcagug caugcuggga      240

gaggugggga uggaguugca ccagaaccag cucgcggggc cagaggacgc ggugcagguc      300

cuggucucuu gccugacuua ggucgcgggg cccagcaaca auuacugcau uuacgccagc      360

gcggagccgg aagggcccca ccuggaguga gacacggugg ugggccucuc cgauugggac      420

ccggcgccag ggguggacga agaggacaug aacccccuuu gcgaccacgu gcggaagggu      480

ugcccgccga ucaaccugca ccaaggcuga gagcuccugc uggggcccgc gagagaggag      540

cugauagagg ugcgaaucca aggagaagac ggcgccgcca accacccaga agaaggcggc      600

ggccucggga agcucgacgu agaagaaggc cuguugcagu ggggggggga guugccgguc      660

gcagagcucg aggggcacgc cgacugagac guaggggcgg agccagacgu cccggcgcac      720

cugaacgaag ggcucgauug agagcugguc ggggacggcg aaggcgacgc cguagacgcc      780

guaggcgacg augguggcgc agaccugccc gcggaggagg cccuagaggg agaggcguuc      840

cgggccguuu gccgcgggau ccaggugggg caggaggagg gcuuaggcgc aggccuggcg      900

gacgggcagg ggcagggcgg ucaccagcga ggagagcacc ugccccuggc gccagaggca      960

gagggcggcc agcagcaagg cgaagggccc cgccugccag guuagccgca agggcugcgg     1020

ugagagcccg aagggccggc gccgaugcac cagcccgcgg ccccgcaaga ggccgaaggc     1080

aaaggggccg acgaggaagg cgcgcccgua gagaaccggg caggcggggc ccugguccgg     1140

gcgcugcagc agaaccagca ccagcagaac uucgacggag aagaaggaga gggccugcgc     1200

ucccugagcc agaacccgcc uaggagagcu cgcuuucuug cuguccaauu ucuauuaaag     1260

guuccuuugu ucccuaaguc caacuacuaa acugggggau auuaugaagg gccuugagca     1320

ucuggauucu gccuaauaaa aaacauuuau uuucauugcu gcguccaauc aaccucugga     1380

uuacaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                 1474


<210>  31
<211>  1320
<212>  PRT
<213>  human herpesvirus 2

<400>  31

Met Ser Ala Glu Gln Arg Lys Lys Lys Thr Thr Thr Thr Thr Gln Gly 
1               5                   10                  15      


Arg Gly Ala Glu Val Thr Met Ala Asp Glu Asp Gly Gly Arg Leu Arg 
            20                  25                  30          


Ala Ala Ala Glu Thr Thr Gly Gly Pro Gly Ser Pro Asp Pro Ala Asp 
        35                  40                  45              


Gly Pro Pro Pro Thr Pro Asn Pro Asp Arg Arg Pro Ala Ala Arg Pro 
    50                  55                  60                  


Gly Phe Gly Trp His Gly Gly Pro Glu Glu Asn Glu Asp Glu Asp Asp 
65                  70                  75                  80  


Asp Ala Ala Ala Asp Ala Asp Glu Ala Ala Pro Ala Ser Gly Glu Ala 
                85                  90                  95      


Val Asp Glu Pro Ala Ala Asp Gly Val Val Ser Pro Arg Gln Leu Ala 
            100                 105                 110         


Leu Leu Ala Ser Met Val Asp Glu Ala Val Arg Thr Ile Pro Ser Pro 
        115                 120                 125             


Pro Pro Glu Arg Asp Gly Ala Glu Glu Glu Ala Ala Arg Ser Pro Ser 
    130                 135                 140                 


Pro Pro Arg Thr Pro Ser Met Arg Ala Asp Tyr Gly Glu Glu Asn Asp 
145                 150                 155                 160 


Asp Asp Asp Asp Asp Asp Asp Asp Asp Arg Asp Ala Gly Arg Trp Val 
                165                 170                 175     


Arg Gly Pro Glu Thr Thr Ser Ala Val Arg Gly Ala Tyr Pro Asp Pro 
            180                 185                 190         


Met Ala Ser Leu Ser Pro Arg Pro Pro Ala Pro Arg Arg His His His 
        195                 200                 205             


Arg His His Arg Arg Arg Arg Ala Pro Arg Arg Arg Ser Ala Ala Ser 
    210                 215                 220                 


Asp Ser Ser Lys Ser Gly Ser Ser Ser Ser Ala Ser Ser Ala Ser Ser 
225                 230                 235                 240 


Ser Ala Ser Ser Ser Ser Ser Ala Ser Ala Ser Ser Ser Asp Asp Asp 
                245                 250                 255     


Asp Asp Asp Asp Ala Ala Ala Arg Ala Pro Ala Ser Ala Ala Asp His 
            260                 265                 270         


Ala Ala Gly Gly Thr Leu Gly Ala Asp Asp Glu Glu Ala Gly Val Pro 
        275                 280                 285             


Ala Arg Ala Pro Gly Ala Ala Pro Arg Pro Ser Pro Pro Arg Ala Glu 
    290                 295                 300                 


Pro Ala Pro Gly Ala Gly Ala Gly Ser Ala Arg Thr Pro Ala Ala Thr 
305                 310                 315                 320 


Ala Gly Arg Leu Glu Arg Arg Arg Ala Arg Ala Ala Val Ala Gly Arg 
                325                 330                 335     


Asp Ala Thr Gly Arg Phe Thr Ala Gly Arg Pro Arg Arg Val Glu Leu 
            340                 345                 350         


Asp Ala Asp Ala Ala Ser Gly Ala Phe Tyr Ala Arg Tyr Arg Asp Gly 
        355                 360                 365             


Tyr Val Ser Gly Glu Pro Trp Pro Gly Ala Gly Pro Pro Pro Pro Gly 
    370                 375                 380                 


Arg Val Leu Tyr Gly Gly Leu Gly Asp Ser Arg Pro Gly Leu Trp Gly 
385                 390                 395                 400 


Ala Pro Glu Ala Glu Glu Ala Arg Ala Arg Phe Glu Ala Ser Gly Ala 
                405                 410                 415     


Pro Ala Pro Val Trp Ala Pro Glu Leu Gly Asp Ala Ala Gln Gln Tyr 
            420                 425                 430         


Ala Leu Ile Thr Arg Leu Leu Tyr Thr Pro Asp Ala Glu Ala Met Gly 
        435                 440                 445             


Trp Leu Gln Asn Pro Arg Val Ala Pro Gly Asp Val Ala Leu Asp Gln 
    450                 455                 460                 


Ala Cys Phe Arg Ile Ser Gly Ala Ala Arg Asn Ser Ser Ser Phe Ile 
465                 470                 475                 480 


Ser Gly Ser Val Ala Arg Ala Val Pro His Leu Gly Tyr Ala Met Ala 
                485                 490                 495     


Ala Gly Arg Phe Gly Trp Gly Leu Ala His Val Ala Ala Ala Val Ala 
            500                 505                 510         


Met Ser Arg Arg Tyr Asp Arg Ala Gln Lys Gly Phe Leu Leu Thr Ser 
        515                 520                 525             


Leu Arg Arg Ala Tyr Ala Pro Leu Leu Ala Arg Glu Asn Ala Ala Leu 
    530                 535                 540                 


Thr Gly Ala Arg Thr Pro Asp Asp Gly Gly Asp Ala Asn Arg His Asp 
545                 550                 555                 560 


Gly Asp Asp Ala Arg Gly Lys Pro Ala Ala Ala Ala Ala Pro Leu Pro 
                565                 570                 575     


Ser Ala Ala Ala Ser Pro Ala Asp Glu Arg Ala Val Pro Ala Gly Tyr 
            580                 585                 590         


Gly Ala Ala Gly Val Leu Ala Ala Leu Gly Arg Leu Ser Ala Ala Pro 
        595                 600                 605             


Ala Ser Ala Pro Ala Gly Ala Asp Asp Asp Asp Asp Asp Asp Gly Pro 
    610                 615                 620                 


Gly Gly Gly Gly Gly Gly Arg Arg Ala Glu Ala Gly Arg Val Ala Val 
625                 630                 635                 640 


Glu Cys Leu Ala Ala Cys Arg Gly Ile Leu Glu Ala Leu Ala Glu Gly 
                645                 650                 655     


Phe Asp Gly Asp Leu Ala Ala Val Pro Gly Leu Ala Gly Ala Arg Pro 
            660                 665                 670         


Ala Ala Pro Pro Arg Pro Gly Pro Ala Gly Ala Ala Ala Pro Pro His 
        675                 680                 685             


Ala Asp Ala Pro Arg Leu Arg Ala Trp Leu Arg Glu Leu Arg Phe Val 
    690                 695                 700                 


Arg Asp Ala Leu Val Leu Met Arg Leu Arg Gly Asp Leu Arg Val Ala 
705                 710                 715                 720 


Gly Gly Ser Glu Ala Ala Val Ala Ala Val Arg Ala Val Ser Leu Val 
                725                 730                 735     


Ala Gly Ala Leu Gly Pro Ala Leu Pro Arg Ser Pro Arg Leu Leu Ser 
            740                 745                 750         


Ser Ala Ala Ala Ala Ala Ala Asp Leu Leu Phe Gln Asn Gln Ser Leu 
        755                 760                 765             


Arg Pro Leu Leu Ala Asp Thr Val Ala Ala Ala Asp Ser Leu Ala Ala 
    770                 775                 780                 


Pro Ala Ser Ala Pro Arg Glu Ala Arg Lys Arg Lys Ser Pro Ala Pro 
785                 790                 795                 800 


Ala Arg Ala Pro Pro Gly Gly Ala Pro Arg Pro Pro Lys Lys Ser Arg 
                805                 810                 815     


Ala Asp Ala Pro Arg Pro Ala Ala Ala Pro Pro Ala Gly Ala Ala Pro 
            820                 825                 830         


Pro Ala Pro Pro Thr Pro Pro Pro Arg Pro Pro Arg Pro Ala Ala Leu 
        835                 840                 845             


Thr Arg Arg Pro Ala Glu Gly Pro Asp Pro Gln Gly Gly Trp Arg Arg 
    850                 855                 860                 


Gln Pro Pro Gly Pro Ser His Thr Pro Ala Pro Ser Ala Ala Ala Leu 
865                 870                 875                 880 


Glu Ala Tyr Cys Ala Pro Arg Ala Val Ala Glu Leu Thr Asp His Pro 
                885                 890                 895     


Leu Phe Pro Ala Pro Trp Arg Pro Ala Leu Met Phe Asp Pro Arg Ala 
            900                 905                 910         


Leu Ala Ser Leu Ala Ala Arg Cys Ala Ala Pro Pro Pro Gly Gly Ala 
        915                 920                 925             


Pro Ala Ala Phe Gly Pro Leu Arg Ala Ser Gly Pro Leu Arg Arg Ala 
    930                 935                 940                 


Ala Ala Trp Met Arg Gln Val Pro Asp Pro Glu Asp Val Arg Val Val 
945                 950                 955                 960 


Ile Leu Tyr Ser Pro Leu Pro Gly Glu Asp Leu Ala Ala Gly Arg Ala 
                965                 970                 975     


Gly Gly Gly Pro Pro Pro Glu Trp Ser Ala Glu Arg Gly Gly Leu Ser 
            980                 985                 990         


Cys Leu Leu Ala Ala Leu Gly Asn  Arg Leu Cys Gly Pro  Ala Thr Ala 
        995                 1000                 1005             


Ala Trp  Ala Gly Asn Trp Thr  Gly Ala Pro Asp Val  Ser Ala Leu 
    1010                 1015                 1020             


Gly Ala  Gln Gly Val Leu Leu  Leu Ser Thr Arg Asp  Leu Ala Phe 
    1025                 1030                 1035             


Ala Gly  Ala Val Glu Phe Leu  Gly Leu Leu Ala Gly  Ala Cys Asp 
    1040                 1045                 1050             


Arg Arg  Leu Ile Val Val Asn  Ala Val Arg Ala Ala  Asp Trp Pro 
    1055                 1060                 1065             


Ala Asp  Gly Pro Val Val Ser  Arg Gln His Ala Tyr  Leu Ala Cys 
    1070                 1075                 1080             


Glu Val  Leu Pro Ala Val Gln  Cys Ala Val Arg Trp  Pro Ala Ala 
    1085                 1090                 1095             


Arg Asp  Leu Arg Arg Thr Val  Leu Ala Ser Gly Arg  Val Phe Gly 
    1100                 1105                 1110             


Pro Gly  Val Phe Ala Arg Val  Glu Ala Ala His Ala  Arg Leu Tyr 
    1115                 1120                 1125             


Pro Asp  Ala Pro Pro Leu Arg  Leu Cys Arg Gly Ala  Asn Val Arg 
    1130                 1135                 1140             


Tyr Arg  Val Arg Thr Arg Phe  Gly Pro Asp Thr Leu  Val Pro Met 
    1145                 1150                 1155             


Ser Pro  Arg Glu Tyr Arg Arg  Ala Val Leu Pro Ala  Leu Asp Gly 
    1160                 1165                 1170             


Arg Ala  Ala Ala Ser Gly Ala  Gly Asp Ala Met Ala  Pro Gly Ala 
    1175                 1180                 1185             


Pro Asp  Phe Cys Glu Asp Glu  Ala His Ser His Arg  Ala Cys Ala 
    1190                 1195                 1200             


Arg Trp  Gly Leu Gly Ala Pro  Leu Arg Pro Val Tyr  Val Ala Leu 
    1205                 1210                 1215             


Gly Arg  Asp Ala Val Arg Gly  Gly Pro Ala Glu Leu  Arg Gly Pro 
    1220                 1225                 1230             


Arg Arg  Glu Phe Cys Ala Arg  Ala Leu Leu Glu Pro  Asp Gly Asp 
    1235                 1240                 1245             


Ala Pro  Pro Leu Val Leu Arg  Asp Asp Ala Asp Ala  Gly Pro Pro 
    1250                 1255                 1260             


Pro Gln  Ile Arg Trp Ala Ser  Ala Ala Gly Arg Ala  Gly Thr Val 
    1265                 1270                 1275             


Leu Ala  Ala Ala Gly Gly Gly  Val Glu Val Val Gly  Thr Ala Ala 
    1280                 1285                 1290             


Gly Leu  Ala Thr Pro Pro Arg  Arg Glu Pro Val Asp  Met Asp Ala 
    1295                 1300                 1305             


Glu Leu  Glu Asp Asp Asp Asp  Gly Leu Phe Gly Glu  
    1310                 1315                 1320 


