                         SEQUENCE LISTING

<110>  The University of Bristol
       Syncona Investment Management Limited
       Purespring Therapeutics Limited
 
<120>  PROMOTER

<130>  P121490PCT

<140>  PCT/GB2022/050649
<141>  2022-03-14

<150>  GB 2103470.7
<151>  2021-03-12

<150>  PCT/GB2021/050633
<151>  2021-03-12

<150>  PCT/GB2021/051668
<151>  2021-06-30

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  1249
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary nephrin promoter

<400>  1
cctgcagggc ccactagtct gtaatcccag cattttggga ggctgaggca gatggatcac       60

ctgaggtcag gagttcgaga ccagcctggc caacatgatg aaaccccgtc tctagtaaaa      120

atacaaaaat tagccaggca tggtgctata tacctgtagt accagctact tgggagacag      180

aggtgggaga attacttgaa cctgggaggt tcaagccatg ggaggtggaa gttgcagtga      240

gccgagatgc cactgcactc cagcctgagc aacagagcaa gactatctca agaaaaaaaa      300

gaaagaaaga aagggacttg ccaaggtcat gtatcagggc aaggaagagc tgggggccca      360

gctggctgct cccctgctga gctgggagac caccttgatc tgacttctcc catcttccca      420

gcctaagcca ggccctgggg tcacggaggc tggggaggca ccgaggaacg cgcctggcat      480

gtgctgacag ggaattttat gctccagctg ggccagctgg gaggagcctg ctgggcagag      540

gccagagctg ggggctctgg aaggtacctg ggggaggttg cactgtgaga atgagctcaa      600

gctgggtcag agagcagggc tgactctgcc agtgcctgca tcagcctcat cgctctccta      660

ggctcctggc ctgctggact ctgggctgca ggtccttctt gaaaggctgt gagtagtgag      720

acaaggagca ggagtgaggg gtggcaggag agaagataga gattgagaga gagagagaga      780

gagacagaga gagaggaaga gacagagaca aaaggagaga gaacggctta gacaaggaga      840

gaaagatgga aagataaaga gactgggcgc agtggctcac gcctgtaatc ccaacacttg      900

gggaggccaa ggtgggagga tggcttgaag gaaagagtct gagatcaacc tggccaacat      960

agtgagaccc cgtctctaaa aaaaaaaaag aaaaaaaaaa gaaaaaagaa aaaaaagttt     1020

ttttaaagag acagagaaag agactcagag attgagactg agagcaagac agagagagac     1080

actcacaggg aagaggggaa gaggaaaacg agaaagggag gagagtaacg gaaagagata     1140

aaaaagaaaa gcaggtggca gagacacaga gagagggacc cagagaaagc cagacagacg     1200

caggtggctg gcagcgggcg ctgtgggggt cacagtaggg ggacctgtc                 1249


<210>  2
<211>  819
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary minimal nephrin promoter

<400>  2
ggccctgggg tcacggaggc tggggaggca ccgaggaacg cgcctggcat gtgctgacag       60

ggaattttat gctccagctg ggccagctgg gaggagcctg ctgggcagag gccagagctg      120

ggggctctgg aaggtacctg ggggaggttg cactgtgaga atgagctcaa gctgggtcag      180

agagcagggc tgactctgcc agtgcctgca tcagcctcat cgctctccta ggctcctggc      240

ctgctggact ctgggctgca ggtccttctt gaaaggctgt gagtagtgag acaaggagca      300

ggagtgaggg gtggcaggag agaagataga gattgagaga gagagagaga gagacagaga      360

gagaggaaga gacagagaca aaaggagaga gaacggctta gacaaggaga gaaagatgga      420

aagataaaga gactgggcgc agtggctcac gcctgtaatc ccaacacttg gggaggccaa      480

ggtgggagga tggcttgaag gaaagagtct gagatcaacc tggccaacat agtgagaccc      540

cgtctctaaa aaaaaaaaag aaaaaaaaaa gaaaaaagaa aaaaaagttt ttttaaagag      600

acagagaaag agactcagag attgagactg agagcaagac agagagagac actcacaggg      660

aagaggggaa gaggaaaacg agaaagggag gagagtaacg gaaagagata aaaaagaaaa      720

gcaggtggca gagacacaga gagagggacc cagagaaagc cagacagacg caggtggctg      780

gcagcgggcg ctgtgggggt cacagtaggg ggacctgtc                             819


<210>  3
<211>  265
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary minimal nephrin promoter

<400>  3
ggccctgggg tcacggaggc tggggaggca ccgaggaacg cgcctggcat gtgctgacag       60

ggaattttat gctccaggag caagacagag agagacactc acagggaaga ggggaagagg      120

aaaacgagaa agggaggaga gtaacggaaa gagataaaaa agaaaagcag gtggcagaga      180

cacagagaga gggacccaga gaaagccaga cagacgcagg tggctggcag cgggcgctgt      240

gggggtcaca gtagggggac ctgtc                                            265


<210>  4
<211>  77
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary proximal promoter region

<400>  4
ggccctgggg tcacggaggc tggggaggca ccgaggaacg cgcctggcat gtgctgacag       60

ggaattttat gctccag                                                      77


<210>  5
<211>  32
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary core promoter region

<400>  5
gagcaagaca gagagagaca ctcacaggga ag                                     32


<210>  6
<211>  156
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary 5'UTR

<400>  6
aggggaagag gaaaacgaga aagggaggag agtaacggaa agagataaaa aagaaaagca       60

ggtggcagag acacagagag agggacccag agaaagccag acagacgcag gtggctggca      120

gcgggcgctg tgggggtcac agtaggggga cctgtc                                156


<210>  7
<211>  188
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary core promoter region and 5'UTR

<400>  7
gagcaagaca gagagagaca ctcacaggga agaggggaag aggaaaacga gaaagggagg       60

agagtaacgg aaagagataa aaaagaaaag caggtggcag agacacagag agagggaccc      120

agagaaagcc agacagacgc aggtggctgg cagcgggcgc tgtgggggtc acagtagggg      180

gacctgtc                                                               188


<210>  8
<211>  554
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary optional promoter region

<400>  8
ctgggccagc tgggaggagc ctgctgggca gaggccagag ctgggggctc tggaaggtac       60

ctgggggagg ttgcactgtg agaatgagct caagctgggt cagagagcag ggctgactct      120

gccagtgcct gcatcagcct catcgctctc ctaggctcct ggcctgctgg actctgggct      180

gcaggtcctt cttgaaaggc tgtgagtagt gagacaagga gcaggagtga ggggtggcag      240

gagagaagat agagattgag agagagagag agagagacag agagagagga agagacagag      300

acaaaaggag agagaacggc ttagacaagg agagaaagat ggaaagataa agagactggg      360

cgcagtggct cacgcctgta atcccaacac ttggggaggc caaggtggga ggatggcttg      420

aaggaaagag tctgagatca acctggccaa catagtgaga ccccgtctct aaaaaaaaaa      480

aagaaaaaaa aaagaaaaaa gaaaaaaaag tttttttaaa gagacagaga aagagactca      540

gagattgaga ctga                                                        554


<210>  9
<211>  430
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary optional upstream promoter region

<400>  9
cctgcagggc ccactagtct gtaatcccag cattttggga ggctgaggca gatggatcac       60

ctgaggtcag gagttcgaga ccagcctggc caacatgatg aaaccccgtc tctagtaaaa      120

atacaaaaat tagccaggca tggtgctata tacctgtagt accagctact tgggagacag      180

aggtgggaga attacttgaa cctgggaggt tcaagccatg ggaggtggaa gttgcagtga      240

gccgagatgc cactgcactc cagcctgagc aacagagcaa gactatctca agaaaaaaaa      300

gaaagaaaga aagggacttg ccaaggtcat gtatcagggc aaggaagagc tgggggccca      360

gctggctgct cccctgctga gctgggagac caccttgatc tgacttctcc catcttccca      420

gcctaagcca                                                             430


<210>  10
<211>  7
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary RAR binding site

<400>  10
ggggtca                                                                  7


<210>  11
<211>  17
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary WT1 binding site

<400>  11
cggaggctgg ggaggca                                                      17


<210>  12
<211>  5
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary enhancer box

<400>  12
atgtg                                                                    5


<210>  13
<211>  30
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary transcription factor binding region

<400>  13
gagcaagaca gagagagaca ctcacaggga                                        30


<210>  14
<211>  1192
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary variant nephrin promoter

<400>  14
cacctgaggt caggagttcg agaccagcgt ggccaacatg atgaaacccc gtctctagta       60

aaaatacaaa aattagccag gcatggtgct atatacctgt agcaccagct acttgggaga      120

cagaggtggg agaattactt gaacctggga ggttcaagcc atgggaggtg gaagttgcag      180

tgagccgaga tgccactgca ctccagcctg agcaacagag caagactatc tcaagaaaag      240

aaagaaagaa agaaagagac ttgccaaggt catgtatcag ggcaaggaag agctgggggc      300

ccagctggct gctcccctgc tgagctggga gaccaccttg atctgacttc tcccatcttc      360

ccagcctaag ccaggccctg gggtcacgga ggctggggag gcaccgagga acgcgcctgg      420

catgtgctga caggggattt tatgctccag ctgggccagc tgggaggagc ctgctgggca      480

gaggccagag ctgggggctc tggaaggtac ctgggggagg ttgcactgtg agaatgagct      540

caagctgggt cagagagcag ggctgactct gccagtgcct gcatcagcct catcgctctc      600

ctaggctcct ggcctgctgg actctgggct gcaggtcctt cttgaaaggc tgtgagtagt      660

gagacaagga gcaggagtga ggggtggcag gagagaagat agagattgag agagagagag      720

agagagagac agagagagag gaagagacag agacaaaagg agagagaacg gcttagacaa      780

ggagagaaag atggaaagat aaagagactg ggcgcagtgg ctcacgcctg taatcccaac      840

acttggggag gccaaggtgg gaggatggct tgaaggaaag agtctgagat caacctggcc      900

aacatagtga gaccccgtct ctaaaaaaaa aagaaaaaaa aaagaaaaaa gaaaaaaaag      960

tttttttaaa gagacagaga aagagactca gagattgaga ctgagagcaa gacagagaga     1020

gatactcaca gggaagaggg gaagaggaaa acgagaaagg gaggagagta acggaaagag     1080

ataaaaaaga aaagcaggtg gcagagacac acagagaggg acccagagaa agccagacag     1140

acgcaggtgg ctggcagcgg gcgctgtggg ggtcacagta gggggacctg tg             1192


<210>  15
<211>  819
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary minimal nephrin promoter variant

<400>  15
ggccctgggg tcacggaggc tggggaggca ccgaggaacg cgcctggcat gtgctgacag       60

gggattttat gctccagctg ggccagctgg gaggagcctg ctgggcagag gccagagctg      120

ggggctctgg aaggtacctg ggggaggttg cactgtgaga atgagctcaa gctgggtcag      180

agagcagggc tgactctgcc agtgcctgca tcagcctcat cgctctccta ggctcctggc      240

ctgctggact ctgggctgca ggtccttctt gaaaggctgt gagtagtgag acaaggagca      300

ggagtgaggg gtggcaggag agaagataga gattgagaga gagagagaga gagagacaga      360

gagagaggaa gagacagaga caaaaggaga gagaacggct tagacaagga gagaaagatg      420

gaaagataaa gagactgggc gcagtggctc acgcctgtaa tcccaacact tggggaggcc      480

aaggtgggag gatggcttga aggaaagagt ctgagatcaa cctggccaac atagtgagac      540

cccgtctcta aaaaaaaaag aaaaaaaaaa gaaaaaagaa aaaaaagttt ttttaaagag      600

acagagaaag agactcagag attgagactg agagcaagac agagagagat actcacaggg      660

aagaggggaa gaggaaaacg agaaagggag gagagtaacg gaaagagata aaaaagaaaa      720

gcaggtggca gagacacaca gagagggacc cagagaaagc cagacagacg caggtggctg      780

gcagcgggcg ctgtgggggt cacagtaggg ggacctgtg                             819


<210>  16
<211>  265
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary minimal nephrin promoter variant

<400>  16
ggccctgggg tcacggaggc tggggaggca ccgaggaacg cgcctggcat gtgctgacag       60

gggattttat gctccaggag caagacagag agagatactc acagggaaga ggggaagagg      120

aaaacgagaa agggaggaga gtaacggaaa gagataaaaa agaaaagcag gtggcagaga      180

cacagagaga gggacccaga gaaagccaga cagacgcagg tggctggcag cgggcgctgt      240

gggggtcaca gtagggggac ctgtc                                            265


<210>  17
<211>  77
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary variant proximal promoter region

<400>  17
ggccctgggg tcacggaggc tggggaggca ccgaggaacg cgcctggcat gtgctgacag       60

gggattttat gctccag                                                      77


<210>  18
<211>  32
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary variant core promoter region

<400>  18
gagcaagaca gagagagata ctcacaggga ag                                     32


<210>  19
<211>  156
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary variant 5'UTR

<400>  19
aggggaagag gaaaacgaga aagggaggag agtaacggaa agagataaaa aagaaaagca       60

ggtggcagag acacacagag agggacccag agaaagccag acagacgcag gtggctggca      120

gcgggcgctg tgggggtcac agtaggggga cctgtg                                156


<210>  20
<211>  188
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary variant core promoter region and 5'UTR

<400>  20
gagcaagaca gagagagata ctcacaggga agaggggaag aggaaaacga gaaagggagg       60

agagtaacgg aaagagataa aaaagaaaag caggtggcag agacacacag agagggaccc      120

agagaaagcc agacagacgc aggtggctgg cagcgggcgc tgtgggggtc acagtagggg      180

gacctgtg                                                               188


<210>  21
<211>  1670
<212>  PRT
<213>  Unknown

<220>
<223>  Exemplary COL4A3 amino acid sequence

<400>  21

Met Ser Ala Arg Thr Ala Pro Arg Pro Gln Val Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Val Leu Leu Ala Ala Ala Pro Ala Ala Ser Lys Gly Cys Val 
            20                  25                  30          


Cys Lys Asp Lys Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 
        35                  40                  45              


Gly Glu Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 
    50                  55                  60                  


Phe Thr Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly Ile Ser 
                85                  90                  95      


Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Thr Pro Gly 
            100                 105                 110         


Asn Thr Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys Ser Gly Ser 
        115                 120                 125             


Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly Thr Leu Gly Tyr Pro 
    130                 135                 140                 


Gly Ile Pro Gly Ala Ala Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala 
145                 150                 155                 160 


Lys Glu Glu Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 
            180                 185                 190         


Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala 
        195                 200                 205             


Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly 
    210                 215                 220                 


His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Thr Val Ile Val Thr Leu Thr Gly Pro Asp Asn Arg Thr Asp 
                245                 250                 255     


Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala Met Gly Glu Pro Gly Pro 
            260                 265                 270         


Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu Lys Gly 
        275                 280                 285             


Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly Lys Asp Gly Val 
    290                 295                 300                 


Pro Gly Phe Pro Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro 
305                 310                 315                 320 


Gly Leu Met Gly Glu Asp Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly 
                325                 330                 335     


Pro Pro Gly Phe Arg Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu 
            340                 345                 350         


Lys Gly Asp Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg 
        355                 360                 365             


Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly 
    370                 375                 380                 


Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys 
385                 390                 395                 400 


Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala Met Gly Thr 
                405                 410                 415     


Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro 
        435                 440                 445             


Gly Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly 
    450                 455                 460                 


Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro 
465                 470                 475                 480 


Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly 
                485                 490                 495     


Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser 
            500                 505                 510         


Pro Gly Ser Pro Gly Asn Thr Gly Leu Pro Gly Phe Pro Gly Phe Pro 
        515                 520                 525             


Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly Glu Thr Leu 
    530                 535                 540                 


Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Thr Pro Gly Val 
                565                 570                 575     


Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 
            580                 585                 590         


Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly 
        595                 600                 605             


Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro 
    610                 615                 620                 


Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Thr Pro Val Pro Gly 
                645                 650                 655     


Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Pro Gln Gly Pro 
            660                 665                 670         


Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro 
        675                 680                 685             


Gly Pro Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu 
705                 710                 715                 720 


Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly 
                725                 730                 735     


Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro 
            740                 745                 750         


Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly 
        755                 760                 765             


Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly Asn 
    770                 775                 780                 


Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Glu Gln Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala 
                805                 810                 815     


Gln Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg 
            820                 825                 830         


Gly Lys Thr Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg 
        835                 840                 845             


Ser Gly Phe Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly His Gln 
    850                 855                 860                 


Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly 
865                 870                 875                 880 


Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly Phe 
                885                 890                 895     


Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro Gly Thr Pro 
            900                 905                 910         


Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly 
        915                 920                 925             


Thr Pro Gly Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro 
    930                 935                 940                 


Ser Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys 
945                 950                 955                 960 


Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly 
                965                 970                 975     


Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro 
            980                 985                 990         


Pro Gly Pro Arg Gly Asp Leu Gly  Ser Thr Gly Asn Pro  Gly Glu Pro 
        995                 1000                 1005             


Gly Leu  Arg Gly Ile Pro Gly  Ser Met Gly Asn Met  Gly Met Pro 
    1010                 1015                 1020             


Gly Ser  Lys Gly Lys Arg Gly  Thr Leu Gly Phe Pro  Gly Arg Ala 
    1025                 1030                 1035             


Gly Arg  Pro Gly Leu Pro Gly  Ile His Gly Leu Gln  Gly Asp Lys 
    1040                 1045                 1050             


Gly Glu  Pro Gly Tyr Ser Glu  Gly Thr Arg Pro Gly  Pro Pro Gly 
    1055                 1060                 1065             


Pro Thr  Gly Asp Pro Gly Leu  Pro Gly Asp Met Gly  Lys Lys Gly 
    1070                 1075                 1080             


Glu Met  Gly Gln Pro Gly Pro  Pro Gly His Leu Gly  Pro Ala Gly 
    1085                 1090                 1095             


Pro Glu  Gly Ala Pro Gly Ser  Pro Gly Ser Pro Gly  Leu Pro Gly 
    1100                 1105                 1110             


Lys Pro  Gly Pro His Gly Asp  Leu Gly Phe Lys Gly  Ile Lys Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Pro Gly Ile  Arg Gly Pro Pro Gly  Leu Pro Gly 
    1130                 1135                 1140             


Phe Pro  Gly Ser Pro Gly Pro  Met Gly Ile Arg Gly  Asp Gln Gly 
    1145                 1150                 1155             


Arg Asp  Gly Ile Pro Gly Pro  Ala Gly Glu Lys Gly  Glu Thr Gly 
    1160                 1165                 1170             


Leu Leu  Arg Ala Pro Pro Gly  Pro Arg Gly Asn Pro  Gly Ala Gln 
    1175                 1180                 1185             


Gly Ala  Lys Gly Asp Arg Gly  Ala Pro Gly Phe Pro  Gly Leu Pro 
    1190                 1195                 1200             


Gly Arg  Lys Gly Ala Met Gly  Asp Ala Gly Pro Arg  Gly Pro Thr 
    1205                 1210                 1215             


Gly Ile  Glu Gly Phe Pro Gly  Pro Pro Gly Leu Pro  Gly Ala Ile 
    1220                 1225                 1230             


Ile Pro  Gly Gln Thr Gly Asn  Arg Gly Pro Pro Gly  Ser Arg Gly 
    1235                 1240                 1245             


Ser Pro  Gly Ala Pro Gly Pro  Pro Gly Pro Pro Gly  Ser His Val 
    1250                 1255                 1260             


Ile Gly  Ile Lys Gly Asp Lys  Gly Ser Met Gly His  Pro Gly Pro 
    1265                 1270                 1275             


Lys Gly  Pro Pro Gly Thr Ala  Gly Asp Met Gly Pro  Pro Gly Arg 
    1280                 1285                 1290             


Leu Gly  Ala Pro Gly Thr Pro  Gly Leu Pro Gly Pro  Arg Gly Asp 
    1295                 1300                 1305             


Pro Gly  Phe Gln Gly Phe Pro  Gly Val Lys Gly Glu  Lys Gly Asn 
    1310                 1315                 1320             


Pro Gly  Phe Leu Gly Ser Ile  Gly Pro Pro Gly Pro  Ile Gly Pro 
    1325                 1330                 1335             


Lys Gly  Pro Pro Gly Val Arg  Gly Asp Pro Gly Thr  Leu Lys Ile 
    1340                 1345                 1350             


Ile Ser  Leu Pro Gly Ser Pro  Gly Pro Pro Gly Thr  Pro Gly Glu 
    1355                 1360                 1365             


Pro Gly  Met Gln Gly Glu Pro  Gly Pro Pro Gly Pro  Pro Gly Asn 
    1370                 1375                 1380             


Leu Gly  Pro Cys Gly Pro Arg  Gly Lys Pro Gly Lys  Asp Gly Lys 
    1385                 1390                 1395             


Pro Gly  Thr Pro Gly Pro Ala  Gly Glu Lys Gly Asn  Lys Gly Ser 
    1400                 1405                 1410             


Lys Gly  Glu Pro Gly Pro Ala  Gly Ser Asp Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Lys Gly  Lys Arg Gly Asp Ser  Gly Ser Pro Ala Thr  Trp Thr Thr 
    1430                 1435                 1440             


Arg Gly  Phe Val Phe Thr Arg  His Ser Gln Thr Thr  Ala Ile Pro 
    1445                 1450                 1455             


Ser Cys  Pro Glu Gly Thr Val  Pro Leu Tyr Ser Gly  Phe Ser Phe 
    1460                 1465                 1470             


Leu Phe  Val Gln Gly Asn Gln  Arg Ala His Gly Gln  Asp Leu Gly 
    1475                 1480                 1485             


Thr Leu  Gly Ser Cys Leu Gln  Arg Phe Thr Thr Met  Pro Phe Leu 
    1490                 1495                 1500             


Phe Cys  Asn Val Asn Asp Val  Cys Asn Phe Ala Ser  Arg Asn Asp 
    1505                 1510                 1515             


Tyr Ser  Tyr Trp Leu Ser Thr  Pro Ala Leu Met Pro  Met Asn Met 
    1520                 1525                 1530             


Ala Pro  Ile Thr Gly Arg Ala  Leu Glu Pro Tyr Ile  Ser Arg Cys 
    1535                 1540                 1545             


Thr Val  Cys Glu Gly Pro Ala  Ile Ala Ile Ala Val  His Ser Gln 
    1550                 1555                 1560             


Thr Thr  Asp Ile Pro Pro Cys  Pro His Gly Trp Ile  Ser Leu Trp 
    1565                 1570                 1575             


Lys Gly  Phe Ser Phe Ile Met  Phe Thr Ser Ala Gly  Ser Glu Gly 
    1580                 1585                 1590             


Thr Gly  Gln Ala Leu Ala Ser  Pro Gly Ser Cys Leu  Glu Glu Phe 
    1595                 1600                 1605             


Arg Ala  Ser Pro Phe Leu Glu  Cys His Gly Arg Gly  Thr Cys Asn 
    1610                 1615                 1620             


Tyr Tyr  Ser Asn Ser Tyr Ser  Phe Trp Leu Ala Ser  Leu Asn Pro 
    1625                 1630                 1635             


Glu Arg  Met Phe Arg Lys Pro  Ile Pro Ser Thr Val  Lys Ala Gly 
    1640                 1645                 1650             


Glu Leu  Glu Lys Ile Ile Ser  Arg Cys Gln Val Cys  Met Lys Lys 
    1655                 1660                 1665             


Arg His  
    1670 


<210>  22
<211>  1690
<212>  PRT
<213>  Unknown

<220>
<223>  Exemplary COL4A4 amino acid sequence

<400>  22

Met Trp Ser Leu His Ile Val Leu Met Arg Cys Ser Phe Arg Leu Thr 
1               5                   10                  15      


Lys Ser Leu Ala Thr Gly Pro Trp Ser Leu Ile Leu Ile Leu Phe Ser 
            20                  25                  30          


Val Gln Tyr Val Tyr Gly Ser Gly Lys Lys Tyr Ile Gly Pro Cys Gly 
        35                  40                  45              


Gly Arg Asp Cys Ser Val Cys His Cys Val Pro Glu Lys Gly Ser Arg 
    50                  55                  60                  


Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Ile Gly Pro Leu Gly 
65                  70                  75                  80  


Ala Pro Gly Pro Ile Gly Leu Ser Gly Glu Lys Gly Met Arg Gly Asp 
                85                  90                  95      


Arg Gly Pro Pro Gly Ala Ala Gly Asp Lys Gly Asp Lys Gly Pro Thr 
            100                 105                 110         


Gly Val Pro Gly Phe Pro Gly Leu Asp Gly Ile Pro Gly His Pro Gly 
        115                 120                 125             


Pro Pro Gly Pro Arg Gly Lys Pro Gly Met Ser Gly His Asn Gly Ser 
    130                 135                 140                 


Arg Gly Asp Pro Gly Phe Pro Gly Gly Arg Gly Ala Leu Gly Pro Gly 
145                 150                 155                 160 


Gly Pro Leu Gly His Pro Gly Glu Lys Gly Glu Lys Gly Asn Ser Val 
                165                 170                 175     


Phe Ile Leu Gly Ala Val Lys Gly Ile Gln Gly Asp Arg Gly Asp Pro 
            180                 185                 190         


Gly Leu Pro Gly Leu Pro Gly Ser Trp Gly Ala Gly Gly Pro Ala Gly 
        195                 200                 205             


Pro Thr Gly Tyr Pro Gly Glu Pro Gly Leu Val Gly Pro Pro Gly Gln 
    210                 215                 220                 


Pro Gly Arg Pro Gly Leu Lys Gly Asn Pro Gly Val Gly Val Lys Gly 
225                 230                 235                 240 


Gln Met Gly Asp Pro Gly Glu Val Gly Gln Gln Gly Ser Pro Gly Pro 
                245                 250                 255     


Thr Leu Leu Val Glu Pro Pro Asp Phe Cys Leu Tyr Lys Gly Glu Lys 
            260                 265                 270         


Gly Ile Lys Gly Ile Pro Gly Met Val Gly Leu Pro Gly Pro Pro Gly 
        275                 280                 285             


Arg Lys Gly Glu Ser Gly Ile Gly Ala Lys Gly Glu Lys Gly Ile Pro 
    290                 295                 300                 


Gly Phe Pro Gly Pro Arg Gly Asp Pro Gly Ser Tyr Gly Ser Pro Gly 
305                 310                 315                 320 


Phe Pro Gly Leu Lys Gly Glu Leu Gly Leu Val Gly Asp Pro Gly Leu 
                325                 330                 335     


Phe Gly Leu Ile Gly Pro Lys Gly Asp Pro Gly Asn Arg Gly His Pro 
            340                 345                 350         


Gly Pro Pro Gly Val Leu Val Thr Pro Pro Leu Pro Leu Lys Gly Pro 
        355                 360                 365             


Pro Gly Asp Pro Gly Phe Pro Gly Arg Tyr Gly Glu Thr Gly Asp Val 
    370                 375                 380                 


Gly Pro Pro Gly Pro Pro Gly Leu Leu Gly Arg Pro Gly Glu Ala Cys 
385                 390                 395                 400 


Ala Gly Met Ile Gly Pro Pro Gly Pro Gln Gly Phe Pro Gly Leu Pro 
                405                 410                 415     


Gly Leu Pro Gly Glu Ala Gly Ile Pro Gly Arg Pro Asp Ser Ala Pro 
            420                 425                 430         


Gly Lys Pro Gly Lys Pro Gly Ser Pro Gly Leu Pro Gly Ala Pro Gly 
        435                 440                 445             


Leu Gln Gly Leu Pro Gly Ser Ser Val Ile Tyr Cys Ser Val Gly Asn 
    450                 455                 460                 


Pro Gly Pro Gln Gly Ile Lys Gly Lys Val Gly Pro Pro Gly Gly Arg 
465                 470                 475                 480 


Gly Pro Lys Gly Glu Lys Gly Asn Glu Gly Leu Cys Ala Cys Glu Pro 
                485                 490                 495     


Gly Pro Met Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly Arg Gln Gly 
            500                 505                 510         


Ser Lys Gly Asp Leu Gly Leu Pro Gly Trp Leu Gly Thr Lys Gly Asp 
        515                 520                 525             


Pro Gly Pro Pro Gly Ala Glu Gly Pro Pro Gly Leu Pro Gly Lys His 
    530                 535                 540                 


Gly Ala Ser Gly Pro Pro Gly Asn Lys Gly Ala Lys Gly Asp Met Val 
545                 550                 555                 560 


Val Ser Arg Val Lys Gly His Lys Gly Glu Arg Gly Pro Asp Gly Pro 
                565                 570                 575     


Pro Gly Phe Pro Gly Gln Pro Gly Ser His Gly Arg Asp Gly His Ala 
            580                 585                 590         


Gly Glu Lys Gly Asp Pro Gly Pro Pro Gly Asp His Glu Asp Ala Thr 
        595                 600                 605             


Pro Gly Gly Lys Gly Phe Pro Gly Pro Leu Gly Pro Pro Gly Lys Ala 
    610                 615                 620                 


Gly Pro Val Gly Pro Pro Gly Leu Gly Phe Pro Gly Pro Pro Gly Glu 
625                 630                 635                 640 


Arg Gly His Pro Gly Val Pro Gly His Pro Gly Val Arg Gly Pro Asp 
                645                 650                 655     


Gly Leu Lys Gly Gln Lys Gly Asp Thr Ile Ser Cys Asn Val Thr Tyr 
            660                 665                 670         


Pro Gly Arg His Gly Pro Pro Gly Phe Asp Gly Pro Pro Gly Pro Lys 
        675                 680                 685             


Gly Phe Pro Gly Pro Gln Gly Ala Pro Gly Leu Ser Gly Ser Asp Gly 
    690                 695                 700                 


His Lys Gly Arg Pro Gly Thr Pro Gly Thr Ala Glu Ile Pro Gly Pro 
705                 710                 715                 720 


Pro Gly Phe Arg Gly Asp Met Gly Asp Pro Gly Phe Gly Gly Glu Lys 
                725                 730                 735     


Gly Ser Ser Pro Val Gly Pro Pro Gly Pro Pro Gly Ser Pro Gly Val 
            740                 745                 750         


Asn Gly Gln Lys Gly Ile Pro Gly Asp Pro Ala Phe Gly His Leu Gly 
        755                 760                 765             


Pro Pro Gly Lys Arg Gly Leu Ser Gly Val Pro Gly Ile Lys Gly Pro 
    770                 775                 780                 


Arg Gly Asp Pro Gly Cys Pro Gly Ala Glu Gly Pro Ala Gly Ile Pro 
785                 790                 795                 800 


Gly Phe Leu Gly Leu Lys Gly Pro Lys Gly Arg Glu Gly His Ala Gly 
                805                 810                 815     


Phe Pro Gly Val Pro Gly Pro Pro Gly His Ser Cys Glu Arg Gly Ala 
            820                 825                 830         


Pro Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Tyr Pro Gly Ser Pro 
        835                 840                 845             


Gly Ala Pro Gly Gly Lys Gly Gln Pro Gly Asp Val Gly Pro Pro Gly 
    850                 855                 860                 


Pro Ala Gly Met Lys Gly Leu Pro Gly Leu Pro Gly Arg Pro Gly Ala 
865                 870                 875                 880 


His Gly Pro Pro Gly Leu Pro Gly Ile Pro Gly Pro Phe Gly Asp Asp 
                885                 890                 895     


Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Pro Arg Gly Leu Pro Gly 
            900                 905                 910         


Phe Pro Gly Phe Pro Gly Glu Arg Gly Lys Pro Gly Ala Glu Gly Cys 
        915                 920                 925             


Pro Gly Ala Lys Gly Glu Pro Gly Glu Lys Gly Met Ser Gly Leu Pro 
    930                 935                 940                 


Gly Asp Arg Gly Leu Arg Gly Ala Lys Gly Ala Ile Gly Pro Pro Gly 
945                 950                 955                 960 


Asp Glu Gly Glu Met Ala Ile Ile Ser Gln Lys Gly Thr Pro Gly Glu 
                965                 970                 975     


Pro Gly Pro Pro Gly Asp Asp Gly Phe Pro Gly Glu Arg Gly Asp Lys 
            980                 985                 990         


Gly Thr Pro Gly Met Gln Gly Arg  Arg Gly Glu Pro Gly  Arg Tyr Gly 
        995                 1000                 1005             


Pro Pro  Gly Phe His Arg Gly  Glu Pro Gly Glu Lys  Gly Gln Pro 
    1010                 1015                 1020             


Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Gly Ser Thr  Gly Leu Arg 
    1025                 1030                 1035             


Gly Phe  Ile Gly Phe Pro Gly  Leu Pro Gly Asp Gln  Gly Glu Pro 
    1040                 1045                 1050             


Gly Ser  Pro Gly Pro Pro Gly  Phe Ser Gly Ile Asp  Gly Ala Arg 
    1055                 1060                 1065             


Gly Pro  Lys Gly Asn Lys Gly  Asp Pro Ala Ser His  Phe Gly Pro 
    1070                 1075                 1080             


Pro Gly  Pro Lys Gly Glu Pro  Gly Ser Pro Gly Cys  Pro Gly His 
    1085                 1090                 1095             


Phe Gly  Ala Ser Gly Glu Gln  Gly Leu Pro Gly Ile  Gln Gly Pro 
    1100                 1105                 1110             


Arg Gly  Ser Pro Gly Arg Pro  Gly Pro Pro Gly Ser  Ser Gly Pro 
    1115                 1120                 1125             


Pro Gly  Cys Pro Gly Asp His  Gly Met Pro Gly Leu  Arg Gly Gln 
    1130                 1135                 1140             


Pro Gly  Glu Met Gly Asp Pro  Gly Pro Arg Gly Leu  Gln Gly Asp 
    1145                 1150                 1155             


Pro Gly  Ile Pro Gly Pro Pro  Gly Ile Lys Gly Pro  Ser Gly Ser 
    1160                 1165                 1170             


Pro Gly  Leu Asn Gly Leu His  Gly Leu Lys Gly Gln  Lys Gly Thr 
    1175                 1180                 1185             


Lys Gly  Ala Ser Gly Leu His  Asp Val Gly Pro Pro  Gly Pro Val 
    1190                 1195                 1200             


Gly Ile  Pro Gly Leu Lys Gly  Glu Arg Gly Asp Pro  Gly Ser Pro 
    1205                 1210                 1215             


Gly Ile  Ser Pro Pro Gly Pro  Arg Gly Lys Lys Gly  Pro Pro Gly 
    1220                 1225                 1230             


Pro Pro  Gly Ser Ser Gly Pro  Pro Gly Pro Ala Gly  Ala Thr Gly 
    1235                 1240                 1245             


Arg Ala  Pro Lys Asp Ile Pro  Asp Pro Gly Pro Pro  Gly Asp Gln 
    1250                 1255                 1260             


Gly Pro  Pro Gly Pro Asp Gly  Pro Arg Gly Ala Pro  Gly Pro Pro 
    1265                 1270                 1275             


Gly Leu  Pro Gly Ser Val Asp  Leu Leu Arg Gly Glu  Pro Gly Asp 
    1280                 1285                 1290             


Cys Gly  Leu Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1295                 1300                 1305             


Pro Gly  Tyr Lys Gly Phe Pro  Gly Cys Asp Gly Lys  Asp Gly Gln 
    1310                 1315                 1320             


Lys Gly  Pro Val Gly Phe Pro  Gly Pro Gln Gly Pro  His Gly Phe 
    1325                 1330                 1335             


Pro Gly  Pro Pro Gly Glu Lys  Gly Leu Pro Gly Pro  Pro Gly Arg 
    1340                 1345                 1350             


Lys Gly  Pro Thr Gly Leu Pro  Gly Pro Arg Gly Glu  Pro Gly Pro 
    1355                 1360                 1365             


Pro Ala  Asp Val Asp Asp Cys  Pro Arg Ile Pro Gly  Leu Pro Gly 
    1370                 1375                 1380             


Ala Pro  Gly Met Arg Gly Pro  Glu Gly Ala Met Gly  Leu Pro Gly 
    1385                 1390                 1395             


Met Arg  Gly Pro Ser Gly Pro  Gly Cys Lys Gly Glu  Pro Gly Leu 
    1400                 1405                 1410             


Asp Gly  Arg Arg Gly Val Asp  Gly Val Pro Gly Ser  Pro Gly Pro 
    1415                 1420                 1425             


Pro Gly  Arg Lys Gly Asp Thr  Gly Glu Asp Gly Tyr  Pro Gly Gly 
    1430                 1435                 1440             


Pro Gly  Pro Pro Gly Pro Ile  Gly Asp Pro Gly Pro  Lys Gly Phe 
    1445                 1450                 1455             


Gly Pro  Gly Tyr Leu Gly Gly  Phe Leu Leu Val Leu  His Ser Gln 
    1460                 1465                 1470             


Thr Asp  Gln Glu Pro Thr Cys  Pro Leu Gly Met Pro  Arg Leu Trp 
    1475                 1480                 1485             


Thr Gly  Tyr Ser Leu Leu Tyr  Leu Glu Gly Gln Glu  Lys Ala His 
    1490                 1495                 1500             


Asn Gln  Asp Leu Gly Leu Ala  Gly Ser Cys Leu Pro  Val Phe Ser 
    1505                 1510                 1515             


Thr Leu  Pro Phe Ala Tyr Cys  Asn Ile His Gln Val  Cys His Tyr 
    1520                 1525                 1530             


Ala Gln  Arg Asn Asp Arg Ser  Tyr Trp Leu Ala Ser  Ala Ala Pro 
    1535                 1540                 1545             


Leu Pro  Met Met Pro Leu Ser  Glu Glu Ala Ile Arg  Pro Tyr Val 
    1550                 1555                 1560             


Ser Arg  Cys Ala Val Cys Glu  Ala Pro Ala Gln Ala  Val Ala Val 
    1565                 1570                 1575             


His Ser  Gln Asp Gln Ser Ile  Pro Pro Cys Pro Gln  Thr Trp Arg 
    1580                 1585                 1590             


Ser Leu  Trp Ile Gly Tyr Ser  Phe Leu Met His Thr  Gly Ala Gly 
    1595                 1600                 1605             


Asp Gln  Gly Gly Gly Gln Ala  Leu Met Ser Pro Gly  Ser Cys Leu 
    1610                 1615                 1620             


Glu Asp  Phe Arg Ala Ala Pro  Phe Leu Glu Cys Gln  Gly Arg Gln 
    1625                 1630                 1635             


Gly Thr  Cys His Phe Phe Ala  Asn Lys Tyr Ser Phe  Trp Leu Thr 
    1640                 1645                 1650             


Thr Val  Lys Ala Asp Leu Gln  Phe Ser Ser Ala Pro  Ala Pro Asp 
    1655                 1660                 1665             


Thr Leu  Lys Glu Ser Gln Ala  Gln Arg Gln Lys Ile  Ser Arg Cys 
    1670                 1675                 1680             


Gln Val  Cys Val Lys Tyr Ser  
    1685                 1690 


<210>  23
<211>  1685
<212>  PRT
<213>  Unknown

<220>
<223>  Exemplary COL4A5 amino acid sequence

<400>  23

Met Lys Leu Arg Gly Val Ser Leu Ala Ala Gly Leu Phe Leu Leu Ala 
1               5                   10                  15      


Leu Ser Leu Trp Gly Gln Pro Ala Glu Ala Ala Ala Cys Tyr Gly Cys 
            20                  25                  30          


Ser Pro Gly Ser Lys Cys Asp Cys Ser Gly Ile Lys Gly Glu Lys Gly 
        35                  40                  45              


Glu Arg Gly Phe Pro Gly Leu Glu Gly His Pro Gly Leu Pro Gly Phe 
    50                  55                  60                  


Pro Gly Pro Glu Gly Pro Pro Gly Pro Arg Gly Gln Lys Gly Asp Asp 
65                  70                  75                  80  


Gly Ile Pro Gly Pro Pro Gly Pro Lys Gly Ile Arg Gly Pro Pro Gly 
                85                  90                  95      


Leu Pro Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Met Pro Gly His 
            100                 105                 110         


Asp Gly Ala Pro Gly Pro Gln Gly Ile Pro Gly Cys Asn Gly Thr Lys 
        115                 120                 125             


Gly Glu Arg Gly Phe Pro Gly Ser Pro Gly Phe Pro Gly Leu Gln Gly 
    130                 135                 140                 


Pro Pro Gly Pro Pro Gly Ile Pro Gly Met Lys Gly Glu Pro Gly Ser 
145                 150                 155                 160 


Ile Ile Met Ser Ser Leu Pro Gly Pro Lys Gly Asn Pro Gly Tyr Pro 
                165                 170                 175     


Gly Pro Pro Gly Ile Gln Gly Leu Pro Gly Pro Thr Gly Ile Pro Gly 
            180                 185                 190         


Pro Ile Gly Pro Pro Gly Pro Pro Gly Leu Met Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Leu Pro Gly Pro Lys Gly Asn Met Gly Leu Asn Phe Gln Gly 
    210                 215                 220                 


Pro Lys Gly Glu Lys Gly Glu Gln Gly Leu Gln Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Gln Ile Ser Glu Gln Lys Arg Pro Ile Asp Val Glu Phe Gln 
                245                 250                 255     


Lys Gly Asp Gln Gly Leu Pro Gly Asp Arg Gly Pro Pro Gly Pro Pro 
            260                 265                 270         


Gly Ile Arg Gly Pro Pro Gly Pro Pro Gly Gly Glu Lys Gly Glu Lys 
        275                 280                 285             


Gly Glu Gln Gly Glu Pro Gly Lys Arg Gly Lys Pro Gly Lys Asp Gly 
    290                 295                 300                 


Glu Asn Gly Gln Pro Gly Ile Pro Gly Leu Pro Gly Asp Pro Gly Tyr 
305                 310                 315                 320 


Pro Gly Glu Pro Gly Arg Asp Gly Glu Lys Gly Gln Lys Gly Asp Thr 
                325                 330                 335     


Gly Pro Pro Gly Pro Pro Gly Leu Val Ile Pro Arg Pro Gly Thr Gly 
            340                 345                 350         


Ile Thr Ile Gly Glu Lys Gly Asn Ile Gly Leu Pro Gly Leu Pro Gly 
        355                 360                 365             


Glu Lys Gly Glu Arg Gly Phe Pro Gly Ile Gln Gly Pro Pro Gly Leu 
    370                 375                 380                 


Pro Gly Pro Pro Gly Ala Ala Val Met Gly Pro Pro Gly Pro Pro Gly 
385                 390                 395                 400 


Phe Pro Gly Glu Arg Gly Gln Lys Gly Asp Glu Gly Pro Pro Gly Ile 
                405                 410                 415     


Ser Ile Pro Gly Pro Pro Gly Leu Asp Gly Gln Pro Gly Ala Pro Gly 
            420                 425                 430         


Leu Pro Gly Pro Pro Gly Pro Ala Gly Pro His Ile Pro Pro Ser Asp 
        435                 440                 445             


Glu Ile Cys Glu Pro Gly Pro Pro Gly Pro Pro Gly Ser Pro Gly Asp 
    450                 455                 460                 


Lys Gly Leu Gln Gly Glu Gln Gly Val Lys Gly Asp Lys Gly Asp Thr 
465                 470                 475                 480 


Cys Phe Asn Cys Ile Gly Thr Gly Ile Ser Gly Pro Pro Gly Gln Pro 
                485                 490                 495     


Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Ser Leu Gly Phe Pro Gly 
            500                 505                 510         


Gln Lys Gly Glu Lys Gly Gln Ala Gly Ala Thr Gly Pro Lys Gly Leu 
        515                 520                 525             


Pro Gly Ile Pro Gly Ala Pro Gly Ala Pro Gly Phe Pro Gly Ser Lys 
    530                 535                 540                 


Gly Glu Pro Gly Asp Ile Leu Thr Phe Pro Gly Met Lys Gly Asp Lys 
545                 550                 555                 560 


Gly Glu Leu Gly Ser Pro Gly Ala Pro Gly Leu Pro Gly Leu Pro Gly 
                565                 570                 575     


Thr Pro Gly Gln Asp Gly Leu Pro Gly Leu Pro Gly Pro Lys Gly Glu 
            580                 585                 590         


Pro Gly Gly Ile Thr Phe Lys Gly Glu Arg Gly Pro Pro Gly Asn Pro 
        595                 600                 605             


Gly Leu Pro Gly Leu Pro Gly Asn Ile Gly Pro Met Gly Pro Pro Gly 
    610                 615                 620                 


Phe Gly Pro Pro Gly Pro Val Gly Glu Lys Gly Ile Gln Gly Val Ala 
625                 630                 635                 640 


Gly Asn Pro Gly Gln Pro Gly Ile Pro Gly Pro Lys Gly Asp Pro Gly 
                645                 650                 655     


Gln Thr Ile Thr Gln Pro Gly Lys Pro Gly Leu Pro Gly Asn Pro Gly 
            660                 665                 670         


Arg Asp Gly Asp Val Gly Leu Pro Gly Asp Pro Gly Leu Pro Gly Gln 
        675                 680                 685             


Pro Gly Leu Pro Gly Ile Pro Gly Ser Lys Gly Glu Pro Gly Ile Pro 
    690                 695                 700                 


Gly Ile Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Phe Pro Gly Ile 
705                 710                 715                 720 


Pro Gly Pro Pro Gly Ala Pro Gly Thr Pro Gly Arg Ile Gly Leu Glu 
                725                 730                 735     


Gly Pro Pro Gly Pro Pro Gly Phe Pro Gly Pro Lys Gly Glu Pro Gly 
            740                 745                 750         


Phe Ala Leu Pro Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly Phe Lys 
        755                 760                 765             


Gly Ala Leu Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Pro Pro Gly 
    770                 775                 780                 


Pro Pro Gly Arg Thr Gly Leu Asp Gly Leu Pro Gly Pro Lys Gly Asp 
785                 790                 795                 800 


Val Gly Pro Asn Gly Gln Pro Gly Pro Met Gly Pro Pro Gly Leu Pro 
                805                 810                 815     


Gly Ile Gly Val Gln Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Pro 
            820                 825                 830         


Ile Gly Gln Pro Gly Leu His Gly Ile Pro Gly Glu Lys Gly Asp Pro 
        835                 840                 845             


Gly Pro Pro Gly Leu Asp Val Pro Gly Pro Pro Gly Glu Arg Gly Ser 
    850                 855                 860                 


Pro Gly Ile Pro Gly Ala Pro Gly Pro Ile Gly Pro Pro Gly Ser Pro 
865                 870                 875                 880 


Gly Leu Pro Gly Lys Ala Gly Ala Ser Gly Phe Pro Gly Thr Lys Gly 
                885                 890                 895     


Glu Met Gly Met Met Gly Pro Pro Gly Pro Pro Gly Pro Leu Gly Ile 
            900                 905                 910         


Pro Gly Arg Ser Gly Val Pro Gly Leu Lys Gly Asp Asp Gly Leu Gln 
        915                 920                 925             


Gly Gln Pro Gly Leu Pro Gly Pro Thr Gly Glu Lys Gly Ser Lys Gly 
    930                 935                 940                 


Glu Pro Gly Leu Pro Gly Pro Pro Gly Pro Met Asp Pro Asn Leu Leu 
945                 950                 955                 960 


Gly Ser Lys Gly Glu Lys Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly 
                965                 970                 975     


Val Ser Gly Pro Lys Gly Tyr Gln Gly Leu Pro Gly Asp Pro Gly Gln 
            980                 985                 990         


Pro Gly Leu Ser Gly Gln Pro Gly  Leu Pro Gly Pro Pro  Gly Pro Lys 
        995                 1000                 1005             


Gly Asn  Pro Gly Leu Pro Gly  Gln Pro Gly Leu Ile  Gly Pro Pro 
    1010                 1015                 1020             


Gly Leu  Lys Gly Thr Ile Gly  Asp Met Gly Phe Pro  Gly Pro Gln 
    1025                 1030                 1035             


Gly Val  Glu Gly Pro Pro Gly  Pro Ser Gly Val Pro  Gly Gln Pro 
    1040                 1045                 1050             


Gly Ser  Pro Gly Leu Pro Gly  Gln Lys Gly Asp Lys  Gly Asp Pro 
    1055                 1060                 1065             


Gly Ile  Ser Ser Ile Gly Leu  Pro Gly Leu Pro Gly  Pro Lys Gly 
    1070                 1075                 1080             


Glu Pro  Gly Leu Pro Gly Tyr  Pro Gly Asn Pro Gly  Ile Lys Gly 
    1085                 1090                 1095             


Ser Val  Gly Asp Pro Gly Leu  Pro Gly Leu Pro Gly  Thr Pro Gly 
    1100                 1105                 1110             


Ala Lys  Gly Gln Pro Gly Leu  Pro Gly Phe Pro Gly  Thr Pro Gly 
    1115                 1120                 1125             


Pro Pro  Gly Pro Lys Gly Ile  Ser Gly Pro Pro Gly  Asn Pro Gly 
    1130                 1135                 1140             


Leu Pro  Gly Glu Pro Gly Pro  Val Gly Gly Gly Gly  His Pro Gly 
    1145                 1150                 1155             


Gln Pro  Gly Pro Pro Gly Glu  Lys Gly Lys Pro Gly  Gln Asp Gly 
    1160                 1165                 1170             


Ile Pro  Gly Pro Ala Gly Gln  Lys Gly Glu Pro Gly  Gln Pro Gly 
    1175                 1180                 1185             


Phe Gly  Asn Pro Gly Pro Pro  Gly Leu Pro Gly Leu  Ser Gly Gln 
    1190                 1195                 1200             


Lys Gly  Asp Gly Gly Leu Pro  Gly Ile Pro Gly Asn  Pro Gly Leu 
    1205                 1210                 1215             


Pro Gly  Pro Lys Gly Glu Pro  Gly Phe His Gly Phe  Pro Gly Val 
    1220                 1225                 1230             


Gln Gly  Pro Pro Gly Pro Pro  Gly Ser Pro Gly Pro  Ala Leu Glu 
    1235                 1240                 1245             


Gly Pro  Lys Gly Asn Pro Gly  Pro Gln Gly Pro Pro  Gly Arg Pro 
    1250                 1255                 1260             


Gly Leu  Pro Gly Pro Glu Gly  Pro Pro Gly Leu Pro  Gly Asn Gly 
    1265                 1270                 1275             


Gly Ile  Lys Gly Glu Lys Gly  Asn Pro Gly Gln Pro  Gly Leu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Leu Lys Gly  Asp Gln Gly Pro Pro  Gly Leu Gln 
    1295                 1300                 1305             


Gly Asn  Pro Gly Arg Pro Gly  Leu Asn Gly Met Lys  Gly Asp Pro 
    1310                 1315                 1320             


Gly Leu  Pro Gly Val Pro Gly  Phe Pro Gly Met Lys  Gly Pro Ser 
    1325                 1330                 1335             


Gly Val  Pro Gly Ser Ala Gly  Pro Glu Gly Glu Pro  Gly Leu Ile 
    1340                 1345                 1350             


Gly Pro  Pro Gly Pro Pro Gly  Leu Pro Gly Pro Ser  Gly Gln Ser 
    1355                 1360                 1365             


Ile Ile  Ile Lys Gly Asp Ala  Gly Pro Pro Gly Ile  Pro Gly Gln 
    1370                 1375                 1380             


Pro Gly  Leu Lys Gly Leu Pro  Gly Pro Gln Gly Pro  Gln Gly Leu 
    1385                 1390                 1395             


Pro Gly  Pro Thr Gly Pro Pro  Gly Asp Pro Gly Arg  Asn Gly Leu 
    1400                 1405                 1410             


Pro Gly  Phe Asp Gly Ala Gly  Gly Arg Lys Gly Asp  Pro Gly Leu 
    1415                 1420                 1425             


Pro Gly  Gln Pro Gly Thr Arg  Gly Leu Asp Gly Pro  Pro Gly Pro 
    1430                 1435                 1440             


Asp Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Thr  Ser Ser Val 
    1445                 1450                 1455             


Ala His  Gly Phe Leu Ile Thr  Arg His Ser Gln Thr  Thr Asp Ala 
    1460                 1465                 1470             


Pro Gln  Cys Pro Gln Gly Thr  Leu Gln Val Tyr Glu  Gly Phe Ser 
    1475                 1480                 1485             


Leu Leu  Tyr Val Gln Gly Asn  Lys Arg Ala His Gly  Gln Asp Leu 
    1490                 1495                 1500             


Gly Thr  Ala Gly Ser Cys Leu  Arg Arg Phe Ser Thr  Met Pro Phe 
    1505                 1510                 1515             


Met Phe  Cys Asn Ile Asn Asn  Val Cys Asn Phe Ala  Ser Arg Asn 
    1520                 1525                 1530             


Asp Tyr  Ser Tyr Trp Leu Ser  Thr Pro Glu Pro Met  Pro Met Ser 
    1535                 1540                 1545             


Met Gln  Pro Leu Lys Gly Gln  Ser Ile Gln Pro Phe  Ile Ser Arg 
    1550                 1555                 1560             


Cys Ala  Val Cys Glu Ala Pro  Ala Val Val Ile Ala  Val His Ser 
    1565                 1570                 1575             


Gln Thr  Ile Gln Ile Pro His  Cys Pro Gln Gly Trp  Asp Ser Leu 
    1580                 1585                 1590             


Trp Ile  Gly Tyr Ser Phe Met  Met His Thr Ser Ala  Gly Ala Glu 
    1595                 1600                 1605             


Gly Ser  Gly Gln Ala Leu Ala  Ser Pro Gly Ser Cys  Leu Glu Glu 
    1610                 1615                 1620             


Phe Arg  Ser Ala Pro Phe Ile  Glu Cys His Gly Arg  Gly Thr Cys 
    1625                 1630                 1635             


Asn Tyr  Tyr Ala Asn Ser Tyr  Ser Phe Trp Leu Ala  Thr Val Asp 
    1640                 1645                 1650             


Val Ser  Asp Met Phe Ser Lys  Pro Gln Ser Glu Thr  Leu Lys Ala 
    1655                 1660                 1665             


Gly Asp  Leu Arg Thr Arg Ile  Ser Arg Cys Gln Val  Cys Met Lys 
    1670                 1675                 1680             


Arg Thr  
    1685 


<210>  24
<211>  5013
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary COL4A3 transgene sequence

<400>  24
atgagcgccc ggaccgcccc caggccgcag gtgctcctgc tgccgctcct gctggtgctc       60

ctggcggcgg cgcccgcagc cagcaagggt tgtgtctgta aagacaaagg ccagtgcttc      120

tgtgacgggg ccaaagggga gaagggggag aagggctttc ctggaccccc cggttctcct      180

ggccagaaag gattcacagg tcctgaaggc ttgcctggac cgcagggacc caagggcttt      240

ccaggacttc caggactcac gggttccaaa ggtgtaaggg gaataagtgg attgccagga      300

ttttctggtt ctcctggact tccaggcacc ccaggcaata ccgggcctta cggacttgtc      360

ggtgtaccag gatgcagtgg ttctaagggt gagcaggggt ttccaggact cccagggaca      420

ctgggctacc cagggatccc gggtgctgct ggtttgaaag gacaaaaggg tgctcctgct      480

aaagaagaag atatagaact tgatgcaaaa ggcgaccccg ggttgccagg ggctccagga      540

ccccagggtt tgccaggccc tccaggtttt cctgggcctg ttggcccacc tggtcctccg      600

ggattctttg gctttccagg agccatggga cctagaggac ctaagggtca catgggtgaa      660

agagtgatag gacataaagg agagcggggt gtgaaagggt taacaggacc cccgggacca      720

ccaggaacag ttattgtgac cctaactggc ccagataaca gaacggacct caagggggaa      780

aagggagaca agggagcaat gggcgagcct ggacctcctg gaccctcagg actgcctgga      840

gaatcatatg gatctgaaaa gggtgctcct ggagaccctg gcctgcaggg aaaacccgga      900

aaagatggtg ttcctggctt ccctggaagt gagggagtca agggcaacag gggtttccct      960

gggttaatgg gtgaagatgg cattaaggga cagaaagggg acattggccc tccaggattt     1020

cgtggtccaa cagaatatta tgacacatac caggaaaagg gagatgaagg cactccaggc     1080

ccaccagggc ccagaggagc tcgtggccca caaggtccca gtggtccccc cggagttcct     1140

ggaagtcctg gatcatcaag gcctggcctc agaggagccc ctggatggcc aggcctgaaa     1200

ggaagtaaag gggaacgagg ccgcccagga aaggatgcca tggggactcc tgggtcccca     1260

ggttgtgctg gttcaccagg tcttccagga tcaccgggac ctccaggacc gccaggtgac     1320

atcgtttttc gcaagggtcc acctggagat cacggactgc caggctatct agggtctcca     1380

ggaatcccag gagttgatgg gcccaaagga gaaccaggcc tcctgtgtac acagtgccct     1440

tatatcccag ggcctcccgg tctcccagga ttgccagggt tacatggtgt aaaaggaatc     1500

ccaggaagac aaggcgcagc tggcttgaaa ggaagcccag ggtccccagg aaatacaggt     1560

cttccaggat ttccaggttt cccaggtgcc cagggtgacc caggacttaa aggagaaaaa     1620

ggtgaaacac ttcagcctga ggggcaagtg ggtgtcccag gtgacccggg gctcagaggc     1680

caacctggga gaaagggctt ggatggaatt cctggaactc cgggagtgaa aggattacca     1740

ggacctaaag gcgaactggc tctgagtggt gagaaagggg accaaggtcc tccaggggat     1800

cctggctccc ctgggtcccc aggacctgca ggaccagctg gaccacctgg ctacggaccc     1860

caaggagaac ctggtctcca gggcacgcaa ggagttcctg gagcccccgg accacccgga     1920

gaagccggcc ctaggggaga gctcagtgtt tcaacaccag ttccaggccc accaggacct     1980

ccagggcccc ctggccatcc tggcccccaa ggtccacctg gtatccctgg atccctgggg     2040

aaatgtggag atcctggtct tccagggcct gatggtgaac caggaattcc aggaattgga     2100

tttcctgggc ctcctggacc taagggagac caaggttttc caggtacaaa aggatcactg     2160

ggttgtcctg gaaaaatggg agagcctggg ttacctggaa agccaggcct cccaggagcc     2220

aagggagaac cagcagtagc catgcctgga ggaccaggaa caccaggttt tccaggagaa     2280

agaggcaatt ctggggaaca tggagaaatt ggactccctg gacttccagg tctccctgga     2340

actccaggaa atgaagggct tgatggacca cgaggagatc cagggcagcc tggaccacct     2400

ggagaacaag gacccccagg aaggtgcata gagggtccca ggggagccca aggacttcca     2460

ggcttaaatg gattgaaagg gcaacaaggc agaagaggta aaacggggcc aaagggagac     2520

ccaggaattc caggcttgga tagatcagga tttcctggag aaactggatc accaggaatt     2580

ccaggtcatc aaggtgaaat gggaccactg ggtcaaagag gatatccagg aaatccggga     2640

attttagggc caccaggtga agatggagtg attgggatga tgggctttcc tggagccatt     2700

ggccctccag ggccccctgg gaacccaggc acaccagggc agagggggag ccctggaatt     2760

ccaggagtaa agggccagag aggaacccca ggagccaagg gggaacaagg agataaagga     2820

aatcccgggc cttcagagat atcccacgta ataggggaca aaggagaacc aggtctcaaa     2880

ggattcgcag gaaatccagg tgagaaagga aacagaggcg ttccagggat gccaggttta     2940

aagggcctca aaggactacc cggaccagca ggaccaccag gccccagagg agatttgggc     3000

agcactggga atcctggaga accaggactg cgtggtatac caggaagcat ggggaacatg     3060

ggcatgccag gttctaaagg aaaaagggga actttgggat tcccaggtcg agcaggaaga     3120

ccaggcctcc caggtattca tggtctccag ggagataagg gagagccagg ttattcagaa     3180

ggtacaaggc caggaccacc gggaccaacg ggggatccag gactgccggg tgatatggga     3240

aagaaaggag aaatggggca acctggccca cctggacatt tggggcctgc tggacctgag     3300

ggagcccctg gaagtcctgg aagtcctggc ctcccaggaa agccaggtcc tcatggtgat     3360

ttgggtttta aaggaatcaa aggcctcctg ggccctccag gaatcagagg ccctccaggt     3420

cttccaggat ttccaggatc tcctggacca atgggtataa gaggtgacca aggacgtgat     3480

ggaattcctg gtccagccgg agaaaaggga gaaacgggtt tattgagggc ccctccaggc     3540

ccaagaggga accctggtgc tcaaggagcc aaaggagaca ggggagcccc aggttttcct     3600

ggcctcccgg gcagaaaagg ggccatggga gatgctggac ctcgaggacc cacaggcata     3660

gaaggattcc cagggccacc aggtctgccc ggtgcaatta tccctggcca gacaggaaat     3720

cgtggtccac caggctcaag aggaagccca ggtgcgcctg gtccccctgg acctccaggg     3780

agtcatgtaa taggcataaa aggagacaaa gggtctatgg gccaccctgg cccaaaaggt     3840

ccacctggaa ctgcaggaga catgggacca ccaggtcgtc tgggagcacc aggtactcca     3900

ggtcttccag gacccagagg tgatcctgga ttccaggggt ttccaggcgt gaaaggagaa     3960

aagggtaatc ctggatttct aggatccatt ggacctccag gaccaattgg gccaaaagga     4020

ccacctggtg tacgtggaga ccctggcaca cttaagatta tctcccttcc aggaagccca     4080

gggccacctg gcacacctgg agaaccaggg atgcagggag aacctgggcc accagggcca     4140

cctggaaacc taggaccctg tgggccaaga ggtaagccag gcaaggatgg aaaaccagga     4200

actcctggac cagctggaga aaaaggcaac aaaggttcta aaggagagcc aggaccagct     4260

ggatcagatg gattgccagg tttgaaagga aaacgtggag acagtggatc acctgcaacc     4320

tggacaacga gaggctttgt cttcacccga cacagtcaaa ccacagcaat tccttcatgt     4380

ccagagggga cagtgccact ctacagtggg ttttcttttc tttttgtaca aggaaatcaa     4440

cgagcccacg gacaagacct tggaactctt ggcagctgcc tgcagcgatt taccacaatg     4500

ccattcttat tctgcaatgt caatgatgta tgtaattttg catctcgaaa tgattattca     4560

tactggctgt caacaccagc tctgatgcca atgaacatgg ctcccattac tggcagagcc     4620

cttgagcctt atataagcag atgcactgtt tgtgaaggtc ctgcgatcgc catagccgtt     4680

cacagccaaa ccactgacat tcctccatgt cctcacggct ggatttctct ctggaaagga     4740

ttttcattca tcatgttcac aagtgcaggt tctgagggca ccgggcaagc actggcctcc     4800

cctggctcct gcctggaaga attccgagcc agcccatttc tagaatgtca tggaagagga     4860

acgtgcaact actattcaaa ttcctacagt ttctggctgg cttcattaaa cccagaaaga     4920

atgttcagaa agcctattcc atcaactgtg aaagctgggg aattagaaaa aataataagt     4980

cgctgtcagg tgtgcatgaa gaaaagacac tga                                  5013


<210>  25
<211>  5073
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary COL4A4 transgene sequence

<400>  25
atgtggtctc tgcacatagt actaatgagg tgctccttca gattgaccaa gtccttggcc       60

acaggtccct ggtcacttat actcattctc ttttctgtac aatatgtata tgggagtgga      120

aagaaataca ttggtccttg tggaggaaga gattgctctg tttgccactg tgttcctgaa      180

aaggggtctc ggggtccacc aggaccacca gggccacagg gtccaattgg acccctggga      240

gccccaggac ccattgggct ttcaggagag aaaggaatga gaggggaccg cggccctcct      300

ggagcagcag gggacaaagg agataagggt ccaactggtg ttcctggatt tccaggttta      360

gatggcatac ctgggcaccc agggcctcct ggacccagag gcaaacctgg tatgagtggc      420

cacaatggct caagaggtga cccagggttt ccaggaggaa gaggagctct tggcccagga      480

ggccccctag gccatcctgg ggaaaaggga gaaaaaggaa attcagtgtt cattttaggt      540

gccgttaaag gtattcaggg agacagaggg gacccaggac tgcctggctt accaggatct      600

tggggtgcag gaggaccggc aggtcccaca ggatatcctg gagagccagg gttagtggga      660

cctccgggcc aaccagggcg tccaggtttg aagggaaatc ccggtgtggg agtaaagggg      720

caaatgggag acccgggtga ggttggtcag caaggttctc ctggacccac cctgttggta      780

gagccacctg acttttgtct ctataaagga gaaaagggta taaaaggaat tcctggaatg      840

gttggactgc caggaccacc aggacgcaag ggagaatctg gtattggggc aaaaggagaa      900

aaaggtattc ctggatttcc agggcctcgg ggggatcctg gttcctatgg atctccaggt      960

tttccaggat taaagggaga actaggactg gttggagatc ctgggctatt tggattaatt     1020

ggcccaaagg gggatcctgg aaatcgaggg cacccaggac caccaggtgt tttggtgact     1080

ccacctcttc cactcaaagg cccaccaggg gacccagggt tccctggccg ctatggagaa     1140

acaggggatg ttggaccacc tggtccccca ggtctcttgg gcagaccagg ggaagcctgt     1200

gcaggcatga taggaccccc tgggccacaa ggatttcctg gtcttcctgg gcttccagga     1260

gaagctggta ttcctgggag acctgattct gctccaggaa aaccagggaa gccaggatca     1320

cctggcttgc ctggagcacc aggcctgcag ggcctcccag gatcaagtgt gatatactgt     1380

agtgttggga accccggacc acaaggaata aaaggcaaag ttggtccccc aggaggaaga     1440

ggcccaaaag gagaaaaagg aaatgaagga ctctgtgcct gtgagcctgg acccatgggc     1500

ccccctggcc ctccaggact tcctgggagg caggggagta agggagactt ggggctccct     1560

ggctggcttg gaacaaaagg tgacccagga cctcctggtg ctgaaggacc tccagggcta     1620

ccaggaaagc atggtgcctc tggaccacct ggcaacaaag gggcgaaggg tgacatggtt     1680

gtatcaagag ttaaagggca caaaggagaa agaggtcctg atgggccccc aggatttcca     1740

gggcagccag gatcacatgg tcgggatgga catgctggag aaaaagggga tccaggacct     1800

ccaggggatc atgaagatgc gaccccaggt ggtaaaggat ttcctggacc tctgggcccc     1860

ccaggcaaag caggacctgt ggggccccca ggactgggat ttcctggtcc accaggagag     1920

cgaggccacc caggagttcc aggccaccca ggtgtgaggg gccctgatgg cttgaagggt     1980

cagaaaggtg acacaatttc ttgcaacgta acctaccctg ggaggcatgg ccctccaggt     2040

tttgatggac ctccaggtcc gaagggattt ccaggtcccc aaggtgcccc tgggctgagt     2100

ggttcagatg ggcataaagg cagacctggc acaccaggaa cagcggaaat accaggtcca     2160

cctggttttc gtggtgacat gggagatccg ggttttggag gtgaaaaggg gtcctcccct     2220

gttgggcccc caggccctcc cggctcacca ggagtgaatg gtcagaaagg aatcccggga     2280

gaccctgcat ttggtcacct gggacccccg ggaaagaggg gtctttcagg agtgccaggg     2340

ataaaaggac ccagaggtga tccgggatgt ccaggggctg aagggccagc tggcattcct     2400

ggattcctag gtctcaaagg tcccaaaggc agagagggac atgctgggtt tccaggtgtc     2460

ccaggtccac ctggccattc ctgtgaaaga ggtgctccag ggataccagg gcaaccggga     2520

ctccctgggt atccaggtag cccaggtgct ccaggtggga aaggacagcc gggagatgtg     2580

gggcctcccg ggccagctgg aatgaaaggc ctccccggac tcccaggacg gcctggggca     2640

catggtcccc caggcctccc aggaatccca ggtccctttg gagatgatgg gctacctggt     2700

cctccaggtc caaagggacc ccgggggctg cctggtttcc caggttttcc cggagaaaga     2760

ggaaagcctg gtgcagaggg atgtcctggc gcaaagggag aacctggaga gaagggcatg     2820

tctggccttc ctggagaccg gggactgaga ggggccaaag gagccatagg acctcccgga     2880

gatgaaggag aaatggctat catttcacaa aagggaacac ctggggaacc tggacctcct     2940

ggagatgatg gattcccagg agaaagaggt gataaaggaa ctcccgggat gcaagggaga     3000

agaggagagc cgggaagata cggaccacct ggatttcaca gaggggaacc tggtgagaaa     3060

ggtcagccag ggcctcctgg acccccaggc cctccaggct caactggtct aagagggttc     3120

attggttttc caggacttcc aggtgaccag ggtgagccag gttctccagg tccccctgga     3180

ttttcaggaa ttgatggagc aagaggacct aaaggaaaca aaggtgaccc tgccagtcac     3240

tttggtccac ctggtccaaa gggtgagcca ggtagccctg gatgtccagg gcattttgga     3300

gcatccggag agcagggctt gcctggtatt caagggccca gaggatcacc tggaaggcca     3360

gggccacctg gctcctctgg accaccaggg tgcccaggtg atcacgggat gcctgggctg     3420

aggggacagc caggagaaat gggagaccct gggccaagag gcctccaggg ggatccaggg     3480

ataccaggtc ctccgggaat aaaaggtccc tccggatcac ctggcctgaa cggcttgcat     3540

ggattgaaag gtcagaaagg aactaaaggt gcttcaggtt tgcatgatgt ggggccacct     3600

ggtccagtgg gaatacctgg gctaaaaggg gagagaggag accctgggag cccaggaatc     3660

tctcctccag gtcctcgtgg aaagaaaggt cccccaggac ccccagggag ttcaggacca     3720

cctggtcctg caggtgccac aggaagagct cctaaggaca ttcctgaccc gggtccacct     3780

ggagatcagg gacctcctgg tcctgatggc ccaagaggag cacctgggcc tccaggcctc     3840

cctgggagtg ttgaccttct gagaggggag ccaggtgact gtggtctacc agggccacca     3900

ggtccccctg gcccaccagg ccctccagga tacaaaggct ttccaggatg tgatggaaaa     3960

gatggccaga aaggaccagt gggattcccg ggaccgcagg gaccacatgg atttcctggg     4020

ccacctggag agaagggttt acctggacct ccagggagaa aagggcccac tggtcttccg     4080

ggtcccagag gtgaaccggg gccacctgca gatgtggatg actgtccccg aatcccaggc     4140

cttcctgggg cgccaggcat gagaggacca gaaggagcca tggggctccc tggaatgaga     4200

ggcccctcag gaccagggtg caaaggagag cctgggctgg atggcaggag gggtgtggat     4260

ggcgtccctg ggtctcctgg gcctcccgga cgtaaaggtg acacaggaga agacggctac     4320

cctggaggac cagggcctcc tggtcccatt ggggatcctg ggcccaaagg gtttggccct     4380

ggatacctcg gtggcttcct cctggttctc cacagtcaga cggaccagga gcccacctgc     4440

cccctgggca tgcccaggct ctggactggg tatagtctgt tatacctgga agggcaagag     4500

aaagctcaca atcaagacct tggtctggca gggtcttgcc ttcccgtatt tagcacgctg     4560

ccctttgcct actgcaacat ccaccaggtg tgccactatg cccagagaaa cgacagatcc     4620

tactggctgg ccagcgctgc gcccctcccc atgatgccac tctctgaaga ggcgatccgc     4680

ccctatgtca gccgctgtgc ggtatgcgag gccccggccc aggcggtggc ggtgcacagc     4740

caggaccagt ccatcccccc atgtccgcag acctggagga gcctctggat cgggtattca     4800

ttcctgatgc acacaggagc tggggaccaa ggaggagggc aggcccttat gtcacctggc     4860

agctgcctgg aagatttcag agcagcacca ttccttgaat gccagggccg gcagggaact     4920

tgccactttt tcgcaaataa gtatagcttc tggctcacaa cggtgaaagc agacttgcag     4980

ttttcctctg ctccagcacc agacacctta aaagaaagcc aggcccaacg ccagaaaatc     5040

agccggtgcc aggtctgcgt gaagtatagc tag                                  5073


<210>  26
<211>  5058
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary COL4A5 transgene sequence

<400>  26
atgaaactgc gtggagtcag cctggctgcc ggcttgttct tactggccct gagtctttgg       60

gggcagcctg cagaggctgc ggcttgctat gggtgttctc caggatcaaa gtgtgactgc      120

agtggcataa aaggggaaaa gggagagaga gggtttccag gtttggaagg acacccagga      180

ttgcctggat ttccaggtcc agaagggcct ccggggcctc ggggacaaaa gggtgatgat      240

ggaattccag ggccaccagg accaaaagga atcagaggtc ctcctggact tcctggattt      300

ccagggacac caggtcttcc tggaatgcca ggccacgatg gggccccagg acctcaaggt      360

attcccggat gcaatggaac caagggagaa cgtggatttc caggcagtcc cggttttcct      420

ggtttacagg gtcctccagg accccctggg atcccaggta tgaagggtga accaggtagt      480

ataattatgt catcactgcc aggaccaaag ggtaatccag gatatccagg tcctcctgga      540

atacaaggcc tacctggtcc cactggtata ccagggccaa ttggtccccc aggaccacca      600

ggtttgatgg gccctcctgg tccaccagga cttccaggac ctaaggggaa tatgggctta      660

aatttccagg gacccaaagg tgaaaaaggt gagcaaggtc ttcagggccc acctgggcca      720

cctgggcaga tcagtgaaca gaaaagacca attgatgtag agtttcagaa aggagatcag      780

ggacttcctg gtgaccgagg gcctcctgga cctccaggga tacgtggtcc tccaggtccc      840

ccaggtggtg agaaaggtga gaagggtgag caaggagagc caggcaaaag aggtaaacca      900

ggcaaagatg gagaaaatgg ccaaccagga attcctggtt tgcctggtga tcctggttac      960

cctggtgaac ccggaaggga tggtgaaaag ggccaaaaag gtgacactgg cccacctgga     1020

cctcctggac ttgtaattcc tagacctggg actggtataa ctataggaga aaaaggaaac     1080

attgggttgc ctgggttgcc tggagaaaaa ggagagcgag gatttcctgg aatacagggt     1140

ccacctggcc ttcctggacc tccaggggct gcagttatgg gtcctcctgg ccctcctgga     1200

tttcctggag aaaggggtca gaaaggtgat gaaggaccac ctggaatttc cattcctgga     1260

cctcctggac ttgacggaca gcctggggct cctgggcttc cagggcctcc tggccctgct     1320

ggccctcaca ttcctcctag tgatgagata tgtgaaccag gccctccagg ccccccagga     1380

tctccaggtg ataaaggact ccaaggagaa caaggagtga aaggtgacaa aggtgacact     1440

tgcttcaact gcattggaac tggtatttca gggcctccag gtcaacctgg tttgccaggt     1500

ctcccaggtc ctccaggatc tcttggtttc cctggacaga aaggggaaaa aggacaagct     1560

ggtgcaactg gtcccaaagg attaccaggc attccaggag ctccaggtgc tccaggcttt     1620

cctggatcta aaggtgaacc tggtgatatc ctcacttttc caggaatgaa gggtgacaaa     1680

ggagagttgg gttcccctgg agctccaggg cttcctggtt tacctggcac tcctggacag     1740

gatggattgc cagggcttcc tggcccgaaa ggagagcctg gtggaattac ttttaagggt     1800

gaaagaggtc cccctgggaa cccaggttta ccaggcctcc cagggaatat agggcctatg     1860

ggtccccctg gtttcggccc tccaggccca gtaggtgaaa aaggcataca aggtgtggca     1920

ggaaatccag gccagccagg aataccaggt cctaaagggg atccaggtca gactataacc     1980

cagccgggga agcctggctt gcctggtaac ccaggcagag atggtgatgt aggtcttcca     2040

ggtgaccctg gacttccagg gcaaccaggc ttgccaggga tacctggtag caaaggagaa     2100

ccaggtatcc ctggaattgg gcttcctgga ccacctggtc ccaaaggctt tcctggaatt     2160

ccaggacctc caggagcacc tgggacacct ggaagaattg gtctagaagg ccctcctggg     2220

ccacccggct ttccaggacc aaagggtgaa ccaggatttg cattacctgg gccacctggg     2280

ccaccaggac ttccaggttt caaaggagca cttggtccaa aaggtgatcg tggtttccca     2340

ggacctccgg gtcctccagg acgcactggc ttagatgggc tccctggacc aaaaggtgat     2400

gttggaccaa atggacaacc tggaccaatg ggacctcctg ggctgccagg aataggtgtt     2460

cagggaccac caggaccacc agggattcct gggccaatag gtcaacctgg tttacatgga     2520

ataccaggag agaaggggga tccaggacct cctggacttg atgttccagg acccccaggt     2580

gaaagaggca gtccagggat ccccggagca cctggtccta taggacctcc aggatcacca     2640

gggcttccag gaaaagcagg tgcctctgga tttccaggta ccaaaggtga aatgggtatg     2700

atgggacctc caggcccacc aggacctttg ggaattcctg gcaggagtgg tgtacctggt     2760

cttaaaggtg atgatggctt gcagggtcag ccaggacttc ctggccctac aggagaaaaa     2820

ggtagtaaag gagagcctgg ccttccaggc cctcctggac caatggatcc aaatcttctg     2880

ggctcaaaag gagagaaggg ggaacctggc ttaccaggta tacctggagt ttcagggcca     2940

aaaggttatc agggtttgcc tggagaccca gggcaacctg gactgagtgg acaacctgga     3000

ttaccaggac caccaggtcc caaaggtaac cctggtctcc ctggacagcc aggtcttata     3060

ggacctcctg gacttaaagg aaccatcggt gatatgggtt ttccagggcc tcagggtgtg     3120

gaagggcctc ctggaccttc tggagttcct ggacaacctg gctccccagg attacctgga     3180

cagaaaggcg acaaaggtga tcctggtatt tcaagcattg gtcttccagg tcttcctggt     3240

ccaaagggtg agcctggtct gcctggatac ccagggaacc ctggtatcaa aggttctgtg     3300

ggagatcctg gtttgcccgg attaccagga acccctggag caaaaggaca accaggcctt     3360

cctggattcc caggaacccc aggccctcct ggaccaaaag gtattagtgg ccctcctggg     3420

aaccccggcc ttccaggaga acctggtcct gtaggtggtg gaggtcatcc tgggcaacca     3480

gggcctccag gcgaaaaagg caaacccggt caagatggta ttcctggacc agctggacag     3540

aagggtgaac caggtcaacc aggctttgga aacccaggac cccctggact tccaggactt     3600

tctggccaaa agggtgatgg aggattacct gggattccag gaaatcctgg ccttccaggt     3660

ccaaagggcg aaccaggctt tcacggtttc cctggtgtgc agggtccccc aggccctcct     3720

ggttctccgg gtccagctct ggaaggacct aaaggcaacc ctgggcccca aggtcctcct     3780

gggagaccag gtctaccagg tccagaaggt cctccaggtc tccctggaaa tggaggtatt     3840

aaaggagaga agggaaatcc aggccaacct gggctacctg gcttgcctgg tttgaaagga     3900

gatcaaggac caccaggact ccagggtaat cctggccggc cgggtctcaa tggaatgaaa     3960

ggagatcctg gtctccctgg tgttccagga ttcccaggca tgaaaggacc cagtggagta     4020

cctggatcag ctggccctga gggggaaccg ggacttattg gtcctccagg tcctcctgga     4080

ttacctggtc cttcaggaca gagtatcata attaaaggag atgctggtcc tccaggaatc     4140

cctggccagc ctgggctaaa gggtctacca ggaccccaag gacctcaagg cttaccaggt     4200

ccaactggcc ctccaggaga tcctggacgc aatggactcc ctggctttga tggtgcagga     4260

gggcgcaaag gagacccagg tctgccagga cagccaggta cccgtggttt ggatggtccc     4320

cctggtccag atggattgca aggtccccca ggtccccctg gaacctcctc tgttgcacat     4380

ggatttctta ttacacgcca cagccagaca acggatgcac cacaatgccc acagggaaca     4440

cttcaggtct atgaaggctt ttctctcctg tatgtacaag gaaataaaag agcccacggt     4500

caagacttgg ggacggctgg cagctgcctt cgtcgcttta gtaccatgcc tttcatgttc     4560

tgcaacatca ataatgtttg caactttgct tcaagaaatg actattctta ctggctctct     4620

accccagagc ccatgccaat gagcatgcaa cccctaaagg gccagagcat ccagccattc     4680

attagtcgat gtgcagtatg tgaagctcca gctgtggtga tcgcagttca cagtcagacg     4740

atccagattc cccattgtcc tcagggatgg gattctctgt ggattggtta ttccttcatg     4800

atgcatacaa gtgcaggggc agaaggctca ggtcaagccc tagcctcccc tggttcctgc     4860

ttggaagagt ttcgttcagc tcccttcatc gaatgtcatg ggaggggtac ctgtaactac     4920

tatgccaact cctacagctt ttggctggca actgtagatg tgtcagacat gttcagtaaa     4980

cctcagtcag aaacgctgaa agcaggagac ttgaggacac gaattagccg atgtcaagtg     5040

tgcatgaaga ggacataa                                                   5058


<210>  27
<211>  186
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary NPHS1 enhancer

<400>  27
ctgctgagct gggagaccac cttgatctga cttctcccat cttcccagcc taagccaggc       60

cctggggtca cggaggctgg ggaggcaccg aggaacgcgc ctggcatgtg ctgacagggg      120

attttatgct ccagctgggc cagctgggag gagcctgctg ggcagaggcc agagctgggg      180

gctctg                                                                 186


<210>  28
<211>  13
<212>  DNA
<213>  Exemplary Kozak sequence

<400>  28
gccgccacca ugg                                                          13


<210>  29
<211>  589
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary WPRE

<400>  29
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgc                  589


<210>  30
<211>  135
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary SV40pA signal sequence

<400>  30
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

tatcatgtct ggatc                                                       135


<210>  31
<211>  225
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary bGH poly(A) signal sequence

<400>  31
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210>  32
<211>  17
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary soluble neuropilin-1 polyadenylation signal

<400>  32
aaataaaata cgaaatg                                                      17


<210>  33
<211>  735
<212>  PRT
<213>  Unknown

<220>
<223>  Exemplary AAV3B VP1 capsid protein

<400>  33

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735 


<210>  34
<211>  736
<212>  PRT
<213>  Exemplary LK03 VP1 capsid protein

<400>  34

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  35
<211>  736
<212>  PRT
<213>  Unknown

<220>
<223>  Exemplary AAV9 VP1 capsid protein

<400>  35

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  36
<211>  1257
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary VEGFC polynucleotide

<400>  36
atgcacttgc tgggcttctt ctctgtggcg tgttctctgc tcgccgctgc gctgctcccg       60

ggtcctcgcg aggcgcccgc cgccgccgcc gccttcgagt ccggactcga cctctcggac      120

gcggagcccg acgcgggcga ggccacggct tatgcaagca aagatctgga ggagcagtta      180

cggtctgtgt ccagtgtaga tgaactcatg actgtactct acccagaata ttggaaaatg      240

tacaagtgtc agctaaggaa aggaggctgg caacataaca gagaacaggc caacctcaac      300

tcaaggacag aagagactat aaaatttgct gcagcacatt ataatacaga gatcttgaaa      360

agtattgata atgagtggag aaagactcaa tgcatgccac gggaggtgtg tatagatgtg      420

gggaaggagt ttggagtcgc gacaaacacc ttctttaaac ctccatgtgt gtccgtctac      480

agatgtgggg gttgctgcaa tagtgagggg ctgcagtgca tgaacaccag cacgagctac      540

ctcagcaaga cgttatttga aattacagtg cctctctctc aaggccccaa accagtaaca      600

atcagttttg ccaatcacac ttcctgccga tgcatgtcta aactggatgt ttacagacaa      660

gttcattcca ttattagacg ttccctgcca gcaacactac cacagtgtca ggcagcgaac      720

aagacctgcc ccaccaatta catgtggaat aatcacatct gcagatgcct ggctcaggaa      780

gattttatgt tttcctcgga tgctggagat gactcaacag atggattcca tgacatctgt      840

ggaccaaaca aggagctgga tgaagagacc tgtcagtgtg tctgcagagc ggggcttcgg      900

cctgccagct gtggacccca caaagaacta gacagaaact catgccagtg tgtctgtaaa      960

aacaaactct tccccagcca atgtggggcc aaccgagaat ttgatgaaaa cacatgccag     1020

tgtgtatgta aaagaacctg ccccagaaat caacccctaa atcctggaaa atgtgcctgt     1080

gaatgtacag aaagtccaca gaaatgcttg ttaaaaggaa agaagttcca ccaccaaaca     1140

tgcagctgtt acagacggcc atgtacgaac cgccagaagg cttgtgagcc aggattttca     1200

tatagtgaag aagtgtgtcg ttgtgtccct tcatattgga aaagaccaca aatgagc        1257


<210>  37
<211>  6
<212>  DNA
<213>  Unknown

<220>
<223>  transcription factor binding region

<400>  37
tacgat                                                                   6


<210>  38
<211>  6
<212>  DNA
<213>  Unknown

<220>
<223>  transcription factor binding region

<400>  38
tataat                                                                   6


<210>  39
<211>  6
<212>  DNA
<213>  Unknown

<220>
<223>  transcription factor binding region

<400>  39
gatact                                                                   6


<210>  40
<211>  6
<212>  DNA
<213>  transcription factor binding region

<400>  40
tatgat                                                                   6


<210>  41
<211>  6
<212>  DNA
<213>  Unknown

<220>
<223>  transcription factor binding region

<400>  41
tatgtt                                                                   6


<210>  42
<211>  50
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary chicken beta-globin polyadenylation signal

<400>  42
caataaaaga tctttatttt cattagatct gtgtgttggt tttttgtgtg                  50


<210>  43
<211>  30
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary transcription factor binding region

<400>  43
gagcaagaca gagagagata ctcacaggga                                        30


<210>  44
<211>  1192
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary variant nephrin promoter

<400>  44
cacctgaggt caggagttcg agaccagcgt ggccaacatg atgaaacccc gtctctagta       60

aaaatacaaa aattagccag gcatggtgct atatacctgt agcaccagct acttgggaga      120

cagaggtggg agaattactt gaacctggga ggttcaagcc atgggaggtg gaagttgcag      180

tgagccgaga tgccactgca ctccagcctg agcaacagag caagactatc tcaagaaaag      240

aaagaaagaa agaaagagac ttgccaaggt catgtatcag ggcaaggaag agctgggggc      300

ccagctggct gctcccctgc tgagctggga gaccaccttg atctgacttc tcccatcttc      360

ccagcctaag ccaggccctg gggtcacgga ggctggggag gcaccgagga acgcgcctgg      420

catgtgctga cagggaattt tatgctccag ctgggccagc tgggaggagc ctgctgggca      480

gaggccagag ctgggggctc tggaaggtac ctgggggagg ttgcactgtg agaatgagct      540

caagctgggt cagagagcag ggctgactct gccagtgcct gcatcagcct catcgctctc      600

ctaggctcct ggcctgctgg actctgggct gcaggtcctt cttgaaaggc tgtgagtagt      660

gagacaagga gcaggagtga ggggtggcag gagagaagat agagattgag agagagagag      720

agagagagac agagagagag gaagagacag agacaaaagg agagagaacg gcttagacaa      780

ggagagaaag atggaaagat aaagagactg ggcgcagtgg ctcacgcctg taatcccaac      840

acttggggag gccaaggtgg gaggatggct tgaaggaaag agtctgagat caacctggcc      900

aacatagtga gaccccgtct ctaaaaaaaa aagaaaaaaa aaagaaaaaa gaaaaaaaag      960

tttttttaaa gagacagaga aagagactca gagattgaga ctgagagcaa gacagagaga     1020

gacactcaca gggaagaggg gaagaggaaa acgagaaagg gaggagagta acggaaagag     1080

ataaaaaaga aaagcaggtg gcagagacac agagagaggg acccagagaa agccagacag     1140

acgcaggtgg ctggcagcgg gcgctgtggg ggtcacagta gggggacctg tc             1192


<210>  45
<211>  1192
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary variant nephrin promoter

<400>  45
cacctgaggt caggagttcg agaccagcgt ggccaacatg atgaaacccc gtctctagta       60

aaaatacaaa aattagccag gcatggtgct atatacctgt agcaccagct acttgggaga      120

cagaggtggg agaattactt gaacctggga ggttcaagcc atgggaggtg gaagttgcag      180

tgagccgaga tgccactgca ctccagcctg agcaacagag caagactatc tcaagaaaag      240

aaagaaagaa agaaagagac ttgccaaggt catgtatcag ggcaaggaag agctgggggc      300

ccagctggct gctcccctgc tgagctggga gaccaccttg atctgacttc tcccatcttc      360

ccagcctaag ccaggccctg gggtcacgga ggctggggag gcaccgagga acgcgcctgg      420

catgtgctga caggggattt tatgctccag ctgggccagc tgggaggagc ctgctgggca      480

gaggccagag ctgggggctc tggaaggtac ctgggggagg ttgcactgtg agaatgagct      540

caagctgggt cagagagcag ggctgactct gccagtgcct gcatcagcct catcgctctc      600

ctaggctcct ggcctgctgg actctgggct gcaggtcctt cttgaaaggc tgtgagtagt      660

gagacaagga gcaggagtga ggggtggcag gagagaagat agagattgag agagagagag      720

agagagagac agagagagag gaagagacag agacaaaagg agagagaacg gcttagacaa      780

ggagagaaag atggaaagat aaagagactg ggcgcagtgg ctcacgcctg taatcccaac      840

acttggggag gccaaggtgg gaggatggct tgaaggaaag agtctgagat caacctggcc      900

aacatagtga gaccccgtct ctaaaaaaaa aagaaaaaaa aaagaaaaaa gaaaaaaaag      960

tttttttaaa gagacagaga aagagactca gagattgaga ctgagagcaa gacagagaga     1020

gatactcaca gggaagaggg gaagaggaaa acgagaaagg gaggagagta acggaaagag     1080

ataaaaaaga aaagcaggtg gcagagacac agagagaggg acccagagaa agccagacag     1140

acgcaggtgg ctggcagcgg gcgctgtggg ggtcacagta gggggacctg tc             1192


<210>  46
<211>  819
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary minimal nephrin promoter variant

<400>  46
ggccctgggg tcacggaggc tggggaggca ccgaggaacg cgcctggcat gtgctgacag       60

gggattttat gctccagctg ggccagctgg gaggagcctg ctgggcagag gccagagctg      120

ggggctctgg aaggtacctg ggggaggttg cactgtgaga atgagctcaa gctgggtcag      180

agagcagggc tgactctgcc agtgcctgca tcagcctcat cgctctccta ggctcctggc      240

ctgctggact ctgggctgca ggtccttctt gaaaggctgt gagtagtgag acaaggagca      300

ggagtgaggg gtggcaggag agaagataga gattgagaga gagagagaga gagacagaga      360

gagaggaaga gacagagaca aaaggagaga gaacggctta gacaaggaga gaaagatgga      420

aagataaaga gactgggcgc agtggctcac gcctgtaatc ccaacacttg gggaggccaa      480

ggtgggagga tggcttgaag gaaagagtct gagatcaacc tggccaacat agtgagaccc      540

cgtctctaaa aaaaaaaaag aaaaaaaaaa gaaaaaagaa aaaaaagttt ttttaaagag      600

acagagaaag agactcagag attgagactg agagcaagac agagagagat actcacaggg      660

aagaggggaa gaggaaaacg agaaagggag gagagtaacg gaaagagata aaaaagaaaa      720

gcaggtggca gagacacaga gagagggacc cagagaaagc cagacagacg caggtggctg      780

gcagcgggcg ctgtgggggt cacagtaggg ggacctgtc                             819


<210>  47
<211>  265
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary minimal nephrin promoter variant

<400>  47
ggccctgggg tcacggaggc tggggaggca ccgaggaacg cgcctggcat gtgctgacag       60

gggattttat gctccaggag caagacagag agagatactc acagggaaga ggggaagagg      120

aaaacgagaa agggaggaga gtaacggaaa gagataaaaa agaaaagcag gtggcagaga      180

cacacagaga gggacccaga gaaagccaga cagacgcagg tggctggcag cgggcgctgt      240

gggggtcaca gtagggggac ctgtg                                            265


<210>  48
<211>  0
<212>  DNA
<213>  Unknown

<220>
<223>  n/a

<400>  48
000

<210>  49
<211>  583
<212>  PRT
<213>  Unknown

<220>
<223>  Illustrative CFI polypeptide sequence

<400>  49

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro 
            340                 345                 350         


Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile 
        355                 360                 365             


Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala 
    370                 375                 380                 


Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile 
385                 390                 395                 400 


His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 
                405                 410                 415     


Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu 
            420                 425                 430         


Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg 
        435                 440                 445             


Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn 
    450                 455                 460                 


Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg 
465                 470                 475                 480 


Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser 
                485                 490                 495     


Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly 
            500                 505                 510         


Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val 
    530                 535                 540                 


Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr 
545                 550                 555                 560 


Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro 
                565                 570                 575     


Phe Ile Ser Gln Tyr Asn Val 
            580             


<210>  50
<211>  1752
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative CFI polynucleotide sequence

<400>  50
atgaagcttc ttcatgtttt cctgttattt ctgtgcttcc acttaaggtt ttgcaaggtc       60

acttatacat ctcaagagga tctggtggag aaaaagtgct tagcaaaaaa atatactcac      120

ctctcctgcg ataaagtctt ctgccagcca tggcagagat gcattgaggg cacctgtgtt      180

tgtaaactac cgtatcagtg cccaaagaat ggcactgcag tgtgtgcaac taacaggaga      240

agcttcccaa catactgtca acaaaagagt ttggaatgtc ttcatccagg gacaaagttt      300

ttaaataacg gaacatgcac agccgaagga aagtttagtg tttccttgaa gcatggaaat      360

acagattcag agggaatagt tgaagtaaaa cttgtggacc aagataagac aatgttcata      420

tgcaaaagca gctggagcat gagggaagcc aacgtggcct gccttgacct tgggtttcaa      480

caaggtgctg atactcaaag aaggtttaag ttgtctgatc tctctataaa ttccactgaa      540

tgtctacatg tgcattgccg aggattagag accagtttgg ctgaatgtac ttttactaag      600

agaagaacta tgggttacca ggatttcgct gatgtggttt gttatacaca gaaagcagat      660

tctccaatgg atgacttctt tcagtgtgtg aatgggaaat acatttctca gatgaaagcc      720

tgtgatggta tcaatgattg tggagaccaa agtgatgaac tgtgttgtaa agcatgccaa      780

ggcaaaggct tccattgcaa atcgggtgtt tgcattccaa gccagtatca atgcaatggt      840

gaggtggact gcattacagg ggaagatgaa gttggctgtg caggctttgc atctgtgact      900

caagaagaaa cagaaatttt gactgctgac atggatgcag aaagaagacg gataaaatca      960

ttattaccta aactatcttg tggagttaaa aacagaatgc acattcgaag gaaacgaatt     1020

gtgggaggaa agcgagcaca actgggagac ctcccatggc aggtggcaat taaggatgcc     1080

agtggaatca cctgtggggg aatttatatt ggtggctgtt ggattctgac tgctgcacat     1140

tgtctcagag ccagtaaaac tcatcgttac caaatatgga caacagtagt agactggata     1200

caccccgacc ttaaacgtat agtaattgaa tacgtggata gaattatttt ccatgaaaac     1260

tacaatgcag gcacttacca aaatgacatc gctttgattg aaatgaaaaa agacggaaac     1320

aaaaaagatt gtgagctgcc tcgttccatc cctgcctgtg tcccctggtc tccttaccta     1380

ttccaaccta atgatacatg catcgtttct ggctggggac gagaaaaaga taacgaaaga     1440

gtcttttcac ttcagtgggg tgaagttaaa ctaataagca actgctctaa gttttacgga     1500

aatcgtttct atgaaaaaga aatggaatgt gcaggtacat atgatggttc catcgatgcc     1560

tgtaaagggg actctggagg ccccttagtc tgtatggatg ccaacaatgt gacttatgtc     1620

tggggtgttg tgagttgggg ggaaaactgt ggaaaaccag agttcccagg tgtttacacc     1680

aaagtggcca attattttga ctggattagc taccatgtag gaaggccttt tatttctcag     1740

tacaatgtat aa                                                         1752


<210>  51
<211>  1231
<212>  PRT
<213>  Unknown

<220>
<223>  Illustrative CFH polypeptide sequence

<400>  51

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  52
<211>  3696
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative CFH polynucleotide sequence

<400>  52
atgagacttc tagcaaagat tatttgcctt atgttatggg ctatttgtgt agcagaagat       60

tgcaatgaac ttcctccaag aagaaataca gaaattctga caggttcctg gtctgaccaa      120

acatatccag aaggcaccca ggctatctat aaatgccgcc ctggatatag atctcttgga      180

aatgtaataa tggtatgcag gaagggagaa tgggttgctc ttaatccatt aaggaaatgt      240

cagaaaaggc cctgtggaca tcctggagat actccttttg gtacttttac ccttacagga      300

ggaaatgtgt ttgaatatgg tgtaaaagct gtgtatacat gtaatgaggg gtatcaattg      360

ctaggtgaga ttaattaccg tgaatgtgac acagatggat ggaccaatga tattcctata      420

tgtgaagttg tgaagtgttt accagtgaca gcaccagaga atggaaaaat tgtcagtagt      480

gcaatggaac cagatcggga ataccatttt ggacaagcag tacggtttgt atgtaactca      540

ggctacaaga ttgaaggaga tgaagaaatg cattgttcag acgatggttt ttggagtaaa      600

gagaaaccaa agtgtgtgga aatttcatgc aaatccccag atgttataaa tggatctcct      660

atatctcaga agattattta taaggagaat gaacgatttc aatataaatg taacatgggt      720

tatgaataca gtgaaagagg agatgctgta tgcactgaat ctggatggcg tccgttgcct      780

tcatgtgaag aaaaatcatg tgataatcct tatattccaa atggtgacta ctcaccttta      840

aggattaaac acagaactgg agatgaaatc acgtaccagt gtagaaatgg tttttatcct      900

gcaacccggg gaaatacagc aaaatgcaca agtactggct ggatacctgc tccgagatgt      960

accttgaaac cttgtgatta tccagacatt aaacatggag gtctatatca tgagaatatg     1020

cgtagaccat actttccagt agctgtagga aaatattact cctattactg tgatgaacat     1080

tttgagactc cgtcaggaag ttactgggat cacattcatt gcacacaaga tggatggtcg     1140

ccagcagtac catgcctcag aaaatgttat tttccttatt tggaaaatgg atataatcaa     1200

aatcatggaa gaaagtttgt acagggtaaa tctatagacg ttgcctgcca tcctggctac     1260

gctcttccaa aagcgcagac cacagttaca tgtatggaga atggctggtc tcctactccc     1320

agatgcatcc gtgtcaaaac atgttccaaa tcaagtatag atattgagaa tgggtttatt     1380

tctgaatctc agtatacata tgccttaaaa gaaaaagcga aatatcaatg caaactagga     1440

tatgtaacag cagatggtga aacatcagga tcaattacat gtgggaaaga tggatggtca     1500

gctcaaccca cgtgcattaa atcttgtgat atcccagtat ttatgaatgc cagaactaaa     1560

aatgacttca catggtttaa gctgaatgac acattggact atgaatgcca tgatggttat     1620

gaaagcaata ctggaagcac cactggttcc atagtgtgtg gttacaatgg ttggtctgat     1680

ttacccatat gttatgaaag agaatgcgaa cttcctaaaa tagatgtaca cttagttcct     1740

gatcgcaaga aagaccagta taaagttgga gaggtgttga aattctcctg caaaccagga     1800

tttacaatag ttggacctaa ttccgttcag tgctaccact ttggattgtc tcctgacctc     1860

ccaatatgta aagagcaagt acaatcatgt ggtccacctc ctgaactcct caatgggaat     1920

gttaaggaaa aaacgaaaga agaatatgga cacagtgaag tggtggaata ttattgcaat     1980

cctagatttc taatgaaggg acctaataaa attcaatgtg ttgatggaga gtggacaact     2040

ttaccagtgt gtattgtgga ggagagtacc tgtggagata tacctgaact tgaacatggc     2100

tgggcccagc tttcttcccc tccttattac tatggagatt cagtggaatt caattgctca     2160

gaatcattta caatgattgg acacagatca attacgtgta ttcatggagt atggacccaa     2220

cttccccagt gtgtggcaat agataaactt aagaagtgca aatcatcaaa tttaattata     2280

cttgaggaac atttaaaaaa caagaaggaa ttcgatcata attctaacat aaggtacaga     2340

tgtagaggaa aagaaggatg gatacacaca gtctgcataa atggaagatg ggatccagaa     2400

gtgaactgct caatggcaca aatacaatta tgcccacctc cacctcagat tcccaattct     2460

cacaatatga caaccacact gaattatcgg gatggagaaa aagtatctgt tctttgccaa     2520

gaaaattatc taattcagga aggagaagaa attacatgca aagatggaag atggcagtca     2580

ataccactct gtgttgaaaa aattccatgt tcacaaccac ctcagataga acacggaacc     2640

attaattcat ccaggtcttc acaagaaagt tatgcacatg ggactaaatt gagttatact     2700

tgtgagggtg gtttcaggat atctgaagaa aatgaaacaa catgctacat gggaaaatgg     2760

agttctccac ctcagtgtga aggccttcct tgtaaatctc cacctgagat ttctcatggt     2820

gttgtagctc acatgtcaga cagttatcag tatggagaag aagttacgta caaatgtttt     2880

gaaggttttg gaattgatgg gcctgcaatt gcaaaatgct taggagaaaa atggtctcac     2940

cctccatcat gcataaaaac agattgtctc agtttaccta gctttgaaaa tgccataccc     3000

atgggagaga agaaggatgt gtataaggcg ggtgagcaag tgacttacac ttgtgcaaca     3060

tattacaaaa tggatggagc cagtaatgta acatgcatta atagcagatg gacaggaagg     3120

ccaacatgca gagacacctc ctgtgtgaat ccgcccacag tacaaaatgc ttatatagtg     3180

tcgagacaga tgagtaaata tccatctggt gagagagtac gttatcaatg taggagccct     3240

tatgaaatgt ttggggatga agaagtgatg tgtttaaatg gaaactggac ggaaccacct     3300

caatgcaaag attctacagg aaaatgtggg ccccctccac ctattgacaa tggggacatt     3360

acttcattcc cgttgtcagt atatgctcca gcttcatcag ttgagtacca atgccagaac     3420

ttgtatcaac ttgagggtaa caagcgaata acatgtagaa atggacaatg gtcagaacca     3480

ccaaaatgct tacatccgtg tgtaatatcc cgagaaatta tggaaaatta taacatagca     3540

ttaaggtgga cagccaaaca gaagctttat tcgagaacag gtgaatcagt tgaatttgtg     3600

tgtaaacggg gatatcgtct ttcatcacgt tctcacacat tgcgaacaac atgttgggat     3660

gggaaactgg agtatccaac ttgtgcaaaa agatag                               3696


<210>  53
<211>  449
<212>  PRT
<213>  Unknown

<220>
<223>  Illustrative FHL-1 polypeptide sequence

<400>  53

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr 
        435                 440                 445             


Leu 
    


<210>  54
<211>  1350
<212>  DNA
<213>  Unknown

<220>
<223>  Illustrative FHL-1 polynucleotide sequence

<400>  54
atgagacttc tagcaaagat tatttgcctt atgttatggg ctatttgtgt agcagaagat       60

tgcaatgaac ttcctccaag aagaaataca gaaattctga caggttcctg gtctgaccaa      120

acatatccag aaggcaccca ggctatctat aaatgccgcc ctggatatag atctcttgga      180

aatgtaataa tggtatgcag gaagggagaa tgggttgctc ttaatccatt aaggaaatgt      240

cagaaaaggc cctgtggaca tcctggagat actccttttg gtacttttac ccttacagga      300

ggaaatgtgt ttgaatatgg tgtaaaagct gtgtatacat gtaatgaggg gtatcaattg      360

ctaggtgaga ttaattaccg tgaatgtgac acagatggat ggaccaatga tattcctata      420

tgtgaagttg tgaagtgttt accagtgaca gcaccagaga atggaaaaat tgtcagtagt      480

gcaatggaac cagatcggga ataccatttt ggacaagcag tacggtttgt atgtaactca      540

ggctacaaga ttgaaggaga tgaagaaatg cattgttcag acgatggttt ttggagtaaa      600

gagaaaccaa agtgtgtgga aatttcatgc aaatccccag atgttataaa tggatctcct      660

atatctcaga agattattta taaggagaat gaacgatttc aatataaatg taacatgggt      720

tatgaataca gtgaaagagg agatgctgta tgcactgaat ctggatggcg tccgttgcct      780

tcatgtgaag aaaaatcatg tgataatcct tatattccaa atggtgacta ctcaccttta      840

aggattaaac acagaactgg agatgaaatc acgtaccagt gtagaaatgg tttttatcct      900

gcaacccggg gaaatacagc aaaatgcaca agtactggct ggatacctgc tccgagatgt      960

accttgaaac cttgtgatta tccagacatt aaacatggag gtctatatca tgagaatatg     1020

cgtagaccat actttccagt agctgtagga aaatattact cctattactg tgatgaacat     1080

tttgagactc cgtcaggaag ttactgggat cacattcatt gcacacaaga tggatggtcg     1140

ccagcagtac catgcctcag aaaatgttat tttccttatt tggaaaatgg atataatcaa     1200

aatcatggaa gaaagtttgt acagggtaaa tctatagacg ttgcctgcca tcctggctac     1260

gctcttccaa aagcgcagac cacagttaca tgtatggaga atggctggtc tcctactccc     1320

agatgcatcc gtgtcagctt taccctctga                                      1350


<210>  55
<211>  383
<212>  PRT
<213>  Unknown

<220>
<223>  Exemplary NPHS2 amino acid sequence

<400>  55

Met Glu Arg Arg Ala Arg Ser Ser Ser Arg Glu Ser Arg Gly Arg Gly 
1               5                   10                  15      


Gly Arg Thr Pro His Lys Glu Asn Lys Arg Ala Lys Ala Glu Arg Ser 
            20                  25                  30          


Gly Gly Gly Arg Gly Arg Gln Glu Ala Gly Pro Glu Pro Ser Gly Ser 
        35                  40                  45              


Gly Arg Ala Gly Thr Pro Gly Glu Pro Arg Ala Pro Ala Ala Thr Val 
    50                  55                  60                  


Val Asp Val Asp Glu Val Arg Gly Ser Gly Glu Glu Gly Thr Glu Val 
65                  70                  75                  80  


Val Ala Leu Leu Glu Ser Glu Arg Pro Glu Glu Gly Thr Lys Ser Ser 
                85                  90                  95      


Gly Leu Gly Ala Cys Glu Trp Leu Leu Val Leu Ile Ser Leu Leu Phe 
            100                 105                 110         


Ile Ile Met Thr Phe Pro Phe Ser Ile Trp Phe Cys Val Lys Val Val 
        115                 120                 125             


Gln Glu Tyr Glu Arg Val Ile Ile Phe Arg Leu Gly His Leu Leu Pro 
    130                 135                 140                 


Gly Arg Ala Lys Gly Pro Gly Leu Phe Phe Phe Leu Pro Cys Leu Asp 
145                 150                 155                 160 


Thr Tyr His Lys Val Asp Leu Arg Leu Gln Thr Leu Glu Ile Pro Phe 
                165                 170                 175     


His Glu Ile Val Thr Lys Asp Met Phe Ile Met Glu Ile Asp Ala Ile 
            180                 185                 190         


Cys Tyr Tyr Arg Met Glu Asn Ala Ser Leu Leu Leu Ser Ser Leu Ala 
        195                 200                 205             


His Val Ser Lys Ala Val Gln Phe Leu Val Gln Thr Thr Met Lys Arg 
    210                 215                 220                 


Leu Leu Ala His Arg Ser Leu Thr Glu Ile Leu Leu Glu Arg Lys Ser 
225                 230                 235                 240 


Ile Ala Gln Asp Ala Lys Val Ala Leu Asp Ser Val Thr Cys Ile Trp 
                245                 250                 255     


Gly Ile Lys Val Glu Arg Ile Glu Ile Lys Asp Val Arg Leu Pro Ala 
            260                 265                 270         


Gly Leu Gln His Ser Leu Ala Val Glu Ala Glu Ala Gln Arg Gln Ala 
        275                 280                 285             


Lys Val Arg Met Ile Ala Ala Glu Ala Glu Lys Ala Ala Ser Glu Ser 
    290                 295                 300                 


Leu Arg Met Ala Ala Glu Ile Leu Ser Gly Thr Pro Ala Ala Val Gln 
305                 310                 315                 320 


Leu Arg Tyr Leu His Thr Leu Gln Ser Leu Ser Thr Glu Lys Pro Ser 
                325                 330                 335     


Thr Val Val Leu Pro Leu Pro Phe Asp Leu Leu Asn Cys Leu Ser Ser 
            340                 345                 350         


Pro Ser Asn Arg Thr Gln Gly Ser Leu Pro Phe Pro Ser Pro Ser Lys 
        355                 360                 365             


Pro Val Glu Pro Leu Asn Pro Lys Lys Lys Asp Ser Pro Met Leu 
    370                 375                 380             


<210>  56
<211>  1149
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary NPHS2 transgene sequence

<400>  56
atggagagga gggcgcggag ctcctccagg gagtcccgcg ggcgaggcgg caggactccg       60

cacaaggaga acaagagggc aaaggccgag aggagcggcg ggggccgcgg gcgccaggag      120

gctgggcccg agccgtcggg ctccggacgg gcggggaccc cgggggagcc ccgagcgccc      180

gccgccacgg tggtggacgt ggatgaggtc cgaggctccg gcgaggaggg caccgaggtg      240

gtggcgctgt tggagagcga gcggcccgag gaaggtacca aatcctccgg cttaggggcc      300

tgtgagtggc ttcttgtcct catttccctg ctcttcatca tcatgacctt ccctttttcc      360

atctggttct gcgtaaaggt tgtacaagag tatgaaagag taattatatt ccgactggga      420

catctgcttc ctggaagagc caaaggccct ggtcttttct tttttttgcc ctgcctggat      480

acctaccaca aggttgacct tcgtctccaa actctggaga taccttttca tgagatcgtg      540

accaaagaca tgtttataat ggagatagat gccatttgct actaccgaat ggaaaatgcc      600

tctcttctcc taagcagtct tgctcatgta tctaaagctg tgcaattcct tgtgcaaacc      660

actatgaagc gtctcctagc acatcgatcc ctcactgaaa ttcttctaga gaggaagagc      720

atcgcccaag atgcaaaggt tgccttggat tcagtgacct gtatttgggg aatcaaagtg      780

gagagaatag aaattaaaga tgtgaggttg ccagctgggc ttcagcactc actggctgtg      840

gaggctgaag cgcaaagaca agccaaagtg cggatgattg ctgcagaagc ggaaaaggct      900

gcttctgagt ccctgaggat ggcagctgag attctgtcag gcacccctgc tgctgttcag      960

cttcgatacc tccacaccct tcagtctctg tccacagaga agccttccac tgtggtttta     1020

cctttgccat ttgacctact gaattgcctg tcttctccca gcaacagaac tcagggaagc     1080

ctccccttcc caagtccttc caaacctgtt gagccactaa atcctaaaaa gaaagactct     1140

cccatgtta                                                             1149


<210>  57
<211>  1152
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary NPHS2 transgene sequence

<400>  57
atggagagga gggcgcggag ctcctccagg gagtcccgcg ggcgaggcgg caggactccg       60

cacaaggaga acaagagggc aaaggccgag aggagcggcg gaggccgcgg gcgccaggag      120

gctgggcccg agccgtcggg ctccggacgg gcggggaccc cgggggagcc ccgagcgccc      180

gccgccacgg tggtggacgt ggatgaggtc cgaggctccg gcgaggaggg caccgaggtg      240

gtggcgctgt tggagagcga gcggcccgag gaaggtacca aatcctccgg cttaggggcc      300

tgtgagtggc ttcttgtcct catttccctg ctcttcatca tcatgacctt ccctttttcc      360

atctggttct gcgtaaaggt tgtacaagag tatgaaagag taattatatt ccgactggga      420

catctgcttc ctggaagagc caaaggccct ggtcttttct tttttttgcc ctgcctggat      480

acctaccaca aggttgacct tcgtctccaa actctggaga taccttttca tgagatcgtg      540

accaaagaca tgtttataat ggagatagat gccatttgct actaccgaat ggaaaatgcc      600

tctcttctcc taagcagtct tgctcatgta tctaaagctg tgcaattcct tgtgcaaacc      660

actatgaagc gtctcctagc acatcgatcc ctcactgaaa ttcttctaga gaggaagagc      720

atcgcccaag atgcaaaggt tgccttggat tcagtgacct gtatttgggg aatcaaagtg      780

gagagaatag aaattaaaga tgtgaggttg ccagctgggc ttcagcactc actggctgtg      840

gaggctgaag cgcaaagaca agccaaagtg cggatgattg ctgcagaagc ggaaaaggct      900

gcttctgagt ccctgaggat ggcagctgag attctgtcag gcacccctgc tgccgttcag      960

cttcgatacc tccacaccct tcagtctctg tccacagaga agccttccac tgtggtttta     1020

cctttgccat ttgacctact gaattgcctg tcttctccca gcaacagaac tcagggaagc     1080

ctccccttcc caagtccttc caaacctgtt gagccactaa atcctaaaaa gaaagactct     1140

cccatgttat ag                                                         1152


<210>  58
<211>  818
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary minimal nephrin promoter

<400>  58
ggccctgggg tcacggaggc tggggaggca ccgaggaacg cgcctggcat gtgctgacag       60

ggaattttat gctccagctg ggccagctgg gaggagcctg ctgggcagag gccagagctg      120

ggggctctgg aaggtacctg ggggaggttg cactgtgaga atgagctcaa gctgggtcag      180

agagcagggc tgactctgcc agtgcctgca tcagcctcat cgctctccta ggctcctggc      240

ctgctggact ctgggctgca ggtccttctt gaaaggctgt gagtagtgag acaaggagca      300

ggagtgaggg gtggcaggag agaagataga gattgagaga gagagagaga gagacagaga      360

gagaggaaga gacagagaca aaaggagaga gaacggctta gacaaggaga gaaagatgga      420

aagataaaga gactgggcgc agtggctcac gcctgtaatc ccaacacttg gggaggccaa      480

ggtgggagga tggcttgaag gaaagagtct gagatcaacc tggccaacat agtgagaccc      540

cgtctctaaa aaaaaaaaag aaaaaaaaaa gaaaaaagaa aaaaaagttt ttttaaagag      600

acagagaaag agactcagag attgagactg agagcaagac agagagagac actcacaggg      660

aagaggggaa gaggaaaacg agaaagggag gagagtaacg gaaagagata aaaaagaaaa      720

gcaggtggca gagacacaga gagagggacc cagagaaagc cagacagacg caggtggctg      780

gcagcgggcg ctgtgggggt cacagtaggg ggacctgt                              818


<210>  59
<211>  818
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary minimal nephrin promoter variant

<400>  59
ggccctgggg tcacggaggc tggggaggca ccgaggaacg cgcctggcat gtgctgacag       60

gggattttat gctccagctg ggccagctgg gaggagcctg ctgggcagag gccagagctg      120

ggggctctgg aaggtacctg ggggaggttg cactgtgaga atgagctcaa gctgggtcag      180

agagcagggc tgactctgcc agtgcctgca tcagcctcat cgctctccta ggctcctggc      240

ctgctggact ctgggctgca ggtccttctt gaaaggctgt gagtagtgag acaaggagca      300

ggagtgaggg gtggcaggag agaagataga gattgagaga gagagagaga gagagacaga      360

gagagaggaa gagacagaga caaaaggaga gagaacggct tagacaagga gagaaagatg      420

gaaagataaa gagactgggc gcagtggctc acgcctgtaa tcccaacact tggggaggcc      480

aaggtgggag gatggcttga aggaaagagt ctgagatcaa cctggccaac atagtgagac      540

cccgtctcta aaaaaaaaag aaaaaaaaaa gaaaaaagaa aaaaaagttt ttttaaagag      600

acagagaaag agactcagag attgagactg agagcaagac agagagagat actcacaggg      660

aagaggggaa gaggaaaacg agaaagggag gagagtaacg gaaagagata aaaaagaaaa      720

gcaggtggca gagacacaca gagagggacc cagagaaagc cagacagacg caggtggctg      780

gcagcgggcg ctgtgggggt cacagtaggg ggacctgt                              818


<210>  60
<211>  818
<212>  DNA
<213>  Unknown

<220>
<223>  Exemplary minimal nephrin promoter variant

<400>  60
ggccctgggg tcacggaggc tggggaggca ccgaggaacg cgcctggcat gtgctgacag       60

gggattttat gctccagctg ggccagctgg gaggagcctg ctgggcagag gccagagctg      120

ggggctctgg aaggtacctg ggggaggttg cactgtgaga atgagctcaa gctgggtcag      180

agagcagggc tgactctgcc agtgcctgca tcagcctcat cgctctccta ggctcctggc      240

ctgctggact ctgggctgca ggtccttctt gaaaggctgt gagtagtgag acaaggagca      300

ggagtgaggg gtggcaggag agaagataga gattgagaga gagagagaga gagacagaga      360

gagaggaaga gacagagaca aaaggagaga gaacggctta gacaaggaga gaaagatgga      420

aagataaaga gactgggcgc agtggctcac gcctgtaatc ccaacacttg gggaggccaa      480

ggtgggagga tggcttgaag gaaagagtct gagatcaacc tggccaacat agtgagaccc      540

cgtctctaaa aaaaaaaaag aaaaaaaaaa gaaaaaagaa aaaaaagttt ttttaaagag      600

acagagaaag agactcagag attgagactg agagcaagac agagagagat actcacaggg      660

aagaggggaa gaggaaaacg agaaagggag gagagtaacg gaaagagata aaaaagaaaa      720

gcaggtggca gagacacaga gagagggacc cagagaaagc cagacagacg caggtggctg      780

gcagcgggcg ctgtgggggt cacagtaggg ggacctgt                              818


<210>  61
<211>  7
<212>  DNA
<213>  Unknown

<220>
<223>  sequence

<400>  61
ggggtca                                                                  7


<210>  62
<211>  17
<212>  DNA
<213>  Unknown

<220>
<223>  sequence

<400>  62
cggaggctgg ggaggca                                                      17


<210>  63
<211>  5
<212>  DNA
<213>  Unknown

<220>
<223>  Sequence

<400>  63
atgtg                                                                    5


