                         SEQUENCE LISTING

<110>  DANA-FARBER CANCER INSTITUTE, INC.
       Qi, Jun
       Durbin, Adam
 
<120>  EP300 DEGRADER AND USES THEREOF IN NEUROBLASTOMA

<130>  52095-718001WO

<150>  63/158,620
<151>  2021-03-09

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  2388
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro 
1               5                   10                  15      


Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp 
            20                  25                  30          


Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile 
        35                  40                  45              


Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu 
    50                  55                  60                  


Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln 
65                  70                  75                  80  


Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly 
                85                  90                  95      


Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser 
            100                 105                 110         


Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln 
        115                 120                 125             


Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn 
    130                 135                 140                 


Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln 
145                 150                 155                 160 


Pro Ala Met Gly Met Asn Thr Gly Met Asn Ala Gly Met Asn Pro Gly 
                165                 170                 175     


Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met 
            180                 185                 190         


Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asn Met Gln Tyr Pro 
        195                 200                 205             


Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln 
    210                 215                 220                 


Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln 
225                 230                 235                 240 


Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro 
                245                 250                 255     


Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu 
            260                 265                 270         


Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala 
        275                 280                 285             


Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln 
    290                 295                 300                 


Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala 
305                 310                 315                 320 


Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys 
                325                 330                 335     


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
            340                 345                 350         


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His 
        355                 360                 365             


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser 
    370                 375                 380                 


Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
385                 390                 395                 400 


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
                405                 410                 415     


Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly 
            420                 425                 430         


Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln 
        435                 440                 445             


Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile 
    450                 455                 460                 


Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met 
465                 470                 475                 480 


Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro 
                485                 490                 495     


Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser 
            500                 505                 510         


Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu 
        515                 520                 525             


Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met 
    530                 535                 540                 


Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala 
545                 550                 555                 560 


Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr 
                565                 570                 575     


Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe 
            580                 585                 590         


Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu 
        595                 600                 605             


Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn 
    610                 615                 620                 


Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile 
625                 630                 635                 640 


Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn 
                645                 650                 655     


Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly 
            660                 665                 670         


Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Ser Leu Asn Gln 
        675                 680                 685             


Phe Gly Gln Met Ser Met Ala Gln Pro Pro Ile Val Pro Arg Gln Thr 
    690                 695                 700                 


Pro Pro Leu Gln His His Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn 
705                 710                 715                 720 


Pro Pro Met Gly Tyr Gly Pro Arg Met Gln Gln Pro Ser Asn Gln Gly 
                725                 730                 735     


Gln Phe Leu Pro Gln Thr Gln Phe Pro Ser Gln Gly Met Asn Val Thr 
            740                 745                 750         


Asn Ile Pro Leu Ala Pro Ser Ser Gly Gln Ala Pro Val Ser Gln Ala 
        755                 760                 765             


Gln Met Ser Ser Ser Ser Cys Pro Val Asn Ser Pro Ile Met Pro Pro 
    770                 775                 780                 


Gly Ser Gln Gly Ser His Ile His Cys Pro Gln Leu Pro Gln Pro Ala 
785                 790                 795                 800 


Leu His Gln Asn Ser Pro Ser Pro Val Pro Ser Arg Thr Pro Thr Pro 
                805                 810                 815     


His His Thr Pro Pro Ser Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr 
            820                 825                 830         


Ile Pro Ala Pro Val Pro Thr Pro Pro Ala Met Pro Pro Gly Pro Gln 
        835                 840                 845             


Ser Gln Ala Leu His Pro Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr 
    850                 855                 860                 


Thr Gln Leu Pro Gln Gln Val Gln Pro Ser Leu Pro Ala Ala Pro Ser 
865                 870                 875                 880 


Ala Asp Gln Pro Gln Gln Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala 
                885                 890                 895     


Ser Val Pro Thr Pro Thr Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr 
            900                 905                 910         


Pro Leu Ser Gln Pro Ala Val Ser Ile Glu Gly Gln Val Ser Asn Pro 
        915                 920                 925             


Pro Ser Thr Ser Ser Thr Glu Val Asn Ser Gln Ala Ile Ala Glu Lys 
    930                 935                 940                 


Gln Pro Ser Gln Glu Val Lys Met Glu Ala Lys Met Glu Val Asp Gln 
945                 950                 955                 960 


Pro Glu Pro Ala Asp Thr Gln Pro Glu Asp Ile Ser Glu Ser Lys Val 
                965                 970                 975     


Glu Asp Cys Lys Met Glu Ser Thr Glu Thr Glu Glu Arg Ser Thr Glu 
            980                 985                 990         


Leu Lys Thr Glu Ile Lys Glu Glu  Glu Asp Gln Pro Ser  Thr Ser Ala 
        995                 1000                 1005             


Thr Gln  Ser Ser Pro Ala Pro  Gly Gln Ser Lys Lys  Lys Ile Phe 
    1010                 1015                 1020             


Lys Pro  Glu Glu Leu Arg Gln  Ala Leu Met Pro Thr  Leu Glu Ala 
    1025                 1030                 1035             


Leu Tyr  Arg Gln Asp Pro Glu  Ser Leu Pro Phe Arg  Gln Pro Val 
    1040                 1045                 1050             


Asp Pro  Gln Leu Leu Gly Ile  Pro Asp Tyr Phe Asp  Ile Val Lys 
    1055                 1060                 1065             


Ser Pro  Met Asp Leu Ser Thr  Ile Lys Arg Lys Leu  Asp Thr Gly 
    1070                 1075                 1080             


Gln Tyr  Gln Glu Pro Trp Gln  Tyr Val Asp Asp Ile  Trp Leu Met 
    1085                 1090                 1095             


Phe Asn  Asn Ala Trp Leu Tyr  Asn Arg Lys Thr Ser  Arg Val Tyr 
    1100                 1105                 1110             


Lys Tyr  Cys Ser Lys Leu Ser  Glu Val Phe Glu Gln  Glu Ile Asp 
    1115                 1120                 1125             


Pro Val  Met Gln Ser Leu Gly  Tyr Cys Cys Gly Arg  Lys Leu Glu 
    1130                 1135                 1140             


Phe Ser  Pro Gln Thr Leu Cys  Cys Tyr Gly Lys Gln  Leu Cys Thr 
    1145                 1150                 1155             


Ile Pro  Arg Asp Ala Thr Tyr  Tyr Ser Tyr Gln Asn  Arg Tyr His 
    1160                 1165                 1170             


Phe Cys  Glu Lys Cys Phe Asn  Glu Ile Gln Gly Glu  Ser Val Ser 
    1175                 1180                 1185             


Leu Gly  Asp Asp Pro Ser Gln  Pro Gln Thr Thr Ile  Asn Lys Glu 
    1190                 1195                 1200             


Gln Phe  Ser Lys Arg Lys Asn  Asp Thr Leu Asp Pro  Glu Leu Phe 
    1205                 1210                 1215             


Val Glu  Cys Thr Glu Cys Gly  Arg Lys Met His Gln  Ile Cys Val 
    1220                 1225                 1230             


Leu His  His Glu Ile Ile Trp  Pro Ala Gly Phe Val  Cys Asp Gly 
    1235                 1240                 1245             


Cys Leu  Lys Lys Ser Ala Arg  Thr Arg Lys Glu Asn  Lys Phe Ser 
    1250                 1255                 1260             


Ala Lys  Arg Leu Pro Ser Thr  Arg Leu Gly Thr Phe  Leu Glu Asn 
    1265                 1270                 1275             


Arg Val  Asn Asp Phe Leu Arg  Arg Gln Asn His Pro  Glu Ser Gly 
    1280                 1285                 1290             


Glu Val  Thr Val Arg Val Val  His Ala Ser Asp Lys  Thr Val Glu 
    1295                 1300                 1305             


Val Lys  Pro Gly Met Lys Ala  Arg Phe Val Asp Ser  Gly Glu Met 
    1310                 1315                 1320             


Ala Glu  Ser Phe Pro Tyr Arg  Thr Lys Ala Leu Phe  Ala Phe Glu 
    1325                 1330                 1335             


Glu Ile  Asp Gly Val Asp Leu  Cys Phe Phe Gly Met  His Val Gln 
    1340                 1345                 1350             


Glu Tyr  Gly Ser Asp Cys Pro  Pro Pro Asn Gln Arg  Arg Val Tyr 
    1355                 1360                 1365             


Ile Ser  Tyr Leu Asp Ser Val  His Phe Phe Arg Pro  Lys Cys Leu 
    1370                 1375                 1380             


Arg Thr  Ala Val Tyr His Glu  Ile Leu Ile Gly Tyr  Leu Glu Tyr 
    1385                 1390                 1395             


Val Lys  Lys Leu Gly Tyr Thr  Thr Gly His Ile Trp  Ala Cys Pro 
    1400                 1405                 1410             


Pro Ser  Glu Gly Asp Asp Tyr  Ile Phe His Cys His  Pro Pro Asp 
    1415                 1420                 1425             


Gln Lys  Ile Pro Lys Pro Lys  Arg Leu Gln Glu Trp  Tyr Lys Lys 
    1430                 1435                 1440             


Met Leu  Asp Lys Ala Val Ser  Glu Arg Ile Val His  Asp Tyr Lys 
    1445                 1450                 1455             


Asp Ile  Phe Lys Gln Ala Thr  Glu Asp Arg Leu Thr  Ser Ala Lys 
    1460                 1465                 1470             


Glu Leu  Pro Tyr Phe Glu Gly  Asp Phe Trp Pro Asn  Val Leu Glu 
    1475                 1480                 1485             


Glu Ser  Ile Lys Glu Leu Glu  Gln Glu Glu Glu Glu  Arg Lys Arg 
    1490                 1495                 1500             


Glu Glu  Asn Thr Ser Asn Glu  Ser Thr Asp Val Thr  Lys Gly Asp 
    1505                 1510                 1515             


Ser Lys  Asn Ala Lys Lys Lys  Asn Asn Lys Lys Thr  Ser Lys Asn 
    1520                 1525                 1530             


Lys Ser  Ser Leu Ser Arg Gly  Asn Lys Lys Lys Pro  Gly Met Pro 
    1535                 1540                 1545             


Asn Val  Ser Asn Asp Leu Ser  Gln Lys Leu Tyr Ala  Thr Met Glu 
    1550                 1555                 1560             


Lys His  Lys Glu Val Phe Phe  Val Ile Arg Leu Ile  Ala Gly Pro 
    1565                 1570                 1575             


Ala Ala  Asn Ser Leu Pro Pro  Ile Val Asp Pro Asp  Pro Leu Ile 
    1580                 1585                 1590             


Pro Cys  Asp Leu Met Asp Gly  Arg Asp Ala Phe Leu  Thr Leu Ala 
    1595                 1600                 1605             


Arg Asp  Lys His Leu Glu Phe  Ser Ser Leu Arg Arg  Ala Gln Trp 
    1610                 1615                 1620             


Ser Thr  Met Cys Met Leu Val  Glu Leu His Thr Gln  Ser Gln Asp 
    1625                 1630                 1635             


Arg Phe  Val Tyr Thr Cys Asn  Glu Cys Lys His His  Val Glu Thr 
    1640                 1645                 1650             


Arg Trp  His Cys Thr Val Cys  Glu Asp Tyr Asp Leu  Cys Ile Thr 
    1655                 1660                 1665             


Cys Tyr  Asn Thr Lys Asn His  Asp His Lys Met Glu  Lys Leu Gly 
    1670                 1675                 1680             


Leu Gly  Leu Asp Asp Glu Ser  Asn Asn Gln Gln Ala  Ala Ala Thr 
    1685                 1690                 1695             


Gln Ser  Pro Gly Asp Ser Arg  Arg Leu Ser Ile Gln  Arg Cys Ile 
    1700                 1705                 1710             


Gln Ser  Leu Val His Ala Cys  Gln Cys Arg Asn Ala  Asn Cys Ser 
    1715                 1720                 1725             


Leu Pro  Ser Cys Gln Lys Met  Lys Arg Val Val Gln  His Thr Lys 
    1730                 1735                 1740             


Gly Cys  Lys Arg Lys Thr Asn  Gly Gly Cys Pro Ile  Cys Lys Gln 
    1745                 1750                 1755             


Leu Ile  Ala Leu Cys Cys Tyr  His Ala Lys His Cys  Gln Glu Asn 
    1760                 1765                 1770             


Lys Cys  Pro Val Pro Phe Cys  Leu Asn Ile Lys Gln  Lys Leu Arg 
    1775                 1780                 1785             


Gln Gln  Gln Leu Gln His Arg  Leu Gln Gln Ala Gln  Met Leu Arg 
    1790                 1795                 1800             


Arg Arg  Met Ala Ser Met Gln  Arg Thr Gly Val Val  Gly Gln Gln 
    1805                 1810                 1815             


Gln Gly  Leu Pro Ser Pro Thr  Pro Ala Thr Pro Thr  Thr Pro Thr 
    1820                 1825                 1830             


Gly Gln  Gln Pro Thr Thr Pro  Gln Thr Pro Gln Pro  Thr Ser Gln 
    1835                 1840                 1845             


Pro Gln  Pro Thr Pro Pro Asn  Ser Met Pro Pro Tyr  Leu Pro Arg 
    1850                 1855                 1860             


Thr Gln  Ala Ala Gly Pro Val  Ser Gln Gly Lys Ala  Ala Gly Gln 
    1865                 1870                 1875             


Val Thr  Pro Pro Thr Pro Pro  Gln Thr Ala Gln Pro  Pro Leu Pro 
    1880                 1885                 1890             


Gly Pro  Pro Pro Ala Ala Val  Glu Met Ala Met Gln  Ile Gln Arg 
    1895                 1900                 1905             


Ala Ala  Glu Thr Gln Arg Gln  Met Ala His Val Gln  Ile Phe Gln 
    1910                 1915                 1920             


Arg Pro  Ile Gln His Gln Met  Pro Pro Met Thr Pro  Met Ala Pro 
    1925                 1930                 1935             


Met Gly  Met Asn Pro Pro Pro  Met Thr Arg Gly Pro  Ser Gly His 
    1940                 1945                 1950             


Leu Glu  Pro Gly Met Gly Pro  Thr Gly Met Gln Gln  Gln Pro Pro 
    1955                 1960                 1965             


Trp Ser  Gln Gly Gly Leu Pro  Gln Pro Gln Gln Leu  Gln Ser Gly 
    1970                 1975                 1980             


Met Pro  Arg Pro Ala Met Met  Ser Val Ala Gln His  Gly Gln Pro 
    1985                 1990                 1995             


Leu Asn  Met Ala Pro Gln Pro  Gly Leu Gly Gln Val  Gly Ile Ser 
    2000                 2005                 2010             


Pro Leu  Lys Pro Gly Thr Val  Ser Gln Gln Ala Leu  Gln Asn Leu 
    2015                 2020                 2025             


Leu Arg  Thr Leu Arg Ser Pro  Ser Ser Pro Leu Gln  Gln Gln Gln 
    2030                 2035                 2040             


Val Leu  Ser Ile Leu His Ala  Asn Pro Gln Leu Leu  Ala Ala Phe 
    2045                 2050                 2055             


Ile Lys  Gln Arg Ala Ala Lys  Tyr Ala Asn Ser Asn  Pro Gln Pro 
    2060                 2065                 2070             


Ile Pro  Gly Gln Pro Gly Met  Pro Gln Gly Gln Pro  Gly Leu Gln 
    2075                 2080                 2085             


Pro Pro  Thr Met Pro Gly Gln  Gln Gly Val His Ser  Asn Pro Ala 
    2090                 2095                 2100             


Met Gln  Asn Met Asn Pro Met  Gln Ala Gly Val Gln  Arg Ala Gly 
    2105                 2110                 2115             


Leu Pro  Gln Gln Gln Pro Gln  Gln Gln Leu Gln Pro  Pro Met Gly 
    2120                 2125                 2130             


Gly Met  Ser Pro Gln Ala Gln  Gln Met Asn Met Asn  His Asn Thr 
    2135                 2140                 2145             


Met Pro  Ser Gln Phe Arg Asp  Ile Leu Arg Arg Gln  Gln Met Met 
    2150                 2155                 2160             


Gln Gln  Gln Gln Gln Gln Gly  Ala Gly Pro Gly Ile  Gly Pro Gly 
    2165                 2170                 2175             


Met Ala  Asn His Asn Gln Phe  Gln Gln Pro Gln Gly  Val Gly Tyr 
    2180                 2185                 2190             


Pro Pro  Gln Gln Gln Gln Arg  Met Gln His His Met  Gln Gln Met 
    2195                 2200                 2205             


Gln Gln  Gly Asn Met Gly Gln  Ile Gly Gln Leu Pro  Gln Ala Leu 
    2210                 2215                 2220             


Gly Ala  Glu Ala Gly Ala Ser  Leu Gln Ala Tyr Gln  Gln Arg Leu 
    2225                 2230                 2235             


Leu Gln  Gln Gln Met Gly Ser  Pro Val Gln Pro Asn  Pro Met Ser 
    2240                 2245                 2250             


Pro Gln  Gln His Met Leu Pro  Asn Gln Ala Gln Ser  Pro His Leu 
    2255                 2260                 2265             


Gln Gly  Gln Gln Ile Pro Asn  Ser Leu Ser Asn Gln  Val Arg Ser 
    2270                 2275                 2280             


Pro Gln  Pro Val Pro Ser Pro  Arg Pro Gln Ser Gln  Pro Pro His 
    2285                 2290                 2295             


Ser Ser  Pro Ser Pro Arg Met  Gln Pro Gln Pro Ser  Pro His His 
    2300                 2305                 2310             


Val Ser  Pro Gln Thr Ser Ser  Pro His Pro Gly Leu  Val Ala Ala 
    2315                 2320                 2325             


Gln Ala  Asn Pro Met Glu Gln  Gly His Phe Ala Ser  Pro Asp Gln 
    2330                 2335                 2340             


Asn Ser  Met Leu Ser Gln Leu  Ala Ser Asn Pro Gly  Met Ala Asn 
    2345                 2350                 2355             


Leu His  Gly Ala Ser Ala Thr  Asp Leu Gly Leu Ser  Thr Asp Asn 
    2360                 2365                 2370             


Ser Asp  Leu Asn Ser Asn Leu  Ser Gln Ser Thr Leu  Asp Ile His 
    2375                 2380                 2385             


<210>  2
<211>  8701
<212>  DNA
<213>  Homo sapiens

<400>  2
gagaaggagg aggacagcgc cgaggaggaa gaggttgatg gcggcggcgg agctccgaga       60

gacctcggct gggcaggggc cggccgtggc gggccgggga ctgcgcctct agagccgcga      120

gttctcggga attcgccgca gcggacgcgc tcggcgaatt tgtgctcttg tgccctcctc      180

cgggcttggg cccaggcccg gcccctcgca cttgccctta ccttttctat cgagtccgca      240

tccctctcca gccactgcga cccggcgaag agaaaaagga acttccccca ccccctcggg      300

tgccgtcgga gccccccagc ccacccctgg gtgcggcgcg gggaccccgg gccgaagaag      360

agatttcctg aggattctgg ttttcctcgc ttgtatctcc gaaagaatta aaaatggccg      420

agaatgtggt ggaaccgggg ccgccttcag ccaagcggcc taaactctca tctccggccc      480

tctcggcgtc cgccagcgat ggcacagatt ttggctctct atttgacttg gagcacgact      540

taccagatga attaatcaac tctacagaat tgggactaac caatggtggt gatattaatc      600

agcttcagac aagtcttggc atggtacaag atgcagcttc taaacataaa cagctgtcag      660

aattgctgcg atctggtagt tcccctaacc tcaatatggg agttggtggc ccaggtcaag      720

tcatggccag ccaggcccaa cagagcagtc ctggattagg tttgataaat agcatggtca      780

aaagcccaat gacacaggca ggcttgactt ctcccaacat ggggatgggc actagtggac      840

caaatcaggg tcctacgcag tcaacaggta tgatgaacag tccagtaaat cagcctgcca      900

tgggaatgaa cacagggatg aatgcgggca tgaatcctgg aatgttggct gcaggcaatg      960

gacaagggat aatgcctaat caagtcatga acggttcaat tggagcaggc cgagggcgac     1020

agaatatgca gtacccaaac ccaggcatgg gaagtgctgg caacttactg actgagcctc     1080

ttcagcaggg ctctccccag atgggaggac aaacaggatt gagaggcccc cagcctctta     1140

agatgggaat gatgaacaac cccaatcctt atggttcacc atatactcag aatcctggac     1200

agcagattgg agccagtggc cttggtctcc agattcagac aaaaactgta ctatcaaata     1260

acttatctcc atttgctatg gacaaaaagg cagttcctgg tggaggaatg cccaacatgg     1320

gtcaacagcc agccccgcag gtccagcagc caggcctggt gactccagtt gcccaaggga     1380

tgggttctgg agcacataca gctgatccag agaagcgcaa gctcatccag cagcagcttg     1440

ttctcctttt gcatgctcac aagtgccagc gccgggaaca ggccaatggg gaagtgaggc     1500

agtgcaacct tccccactgt cgcacaatga agaatgtcct aaaccacatg acacactgcc     1560

agtcaggcaa gtcttgccaa gtggcacact gtgcatcttc tcgacaaatc atttcacact     1620

ggaagaattg tacaagacat gattgtcctg tgtgtctccc cctcaaaaat gctggtgata     1680

agagaaatca acagccaatt ttgactggag cacccgttgg acttggaaat cctagctctc     1740

taggggtggg tcaacagtct gcccccaacc taagcactgt tagtcagatt gatcccagct     1800

ccatagaaag agcctatgca gctcttggac taccctatca agtaaatcag atgccgacac     1860

aaccccaggt gcaagcaaag aaccagcaga atcagcagcc tgggcagtct ccccaaggca     1920

tgcggcccat gagcaacatg agtgctagtc ctatgggagt aaatggaggt gtaggagttc     1980

aaacgccgag tcttctttct gactcaatgt tgcattcagc cataaattct caaaacccaa     2040

tgatgagtga aaatgccagt gtgccctccc tgggtcctat gccaacagca gctcaaccat     2100

ccactactgg aattcggaaa cagtggcacg aagatattac tcaggatctt cgaaatcatc     2160

ttgttcacaa actcgtccaa gccatatttc ctacgccgga tcctgctgct ttaaaagaca     2220

gacggatgga aaacctagtt gcatatgctc ggaaagttga aggggacatg tatgaatctg     2280

caaacaatcg agcggaatac taccaccttc tagctgagaa aatctataag atccagaaag     2340

aactagaaga aaaacgaagg accagactac agaagcagaa catgctacca aatgctgcag     2400

gcatggttcc agtttccatg aatccagggc ctaacatggg acagccgcaa ccaggaatga     2460

cttctagttt gaatcaattt ggccagatga gcatggccca gccccctatt gtaccccggc     2520

aaacccctcc tcttcagcac catggacagt tggctcaacc tggagctctc aacccgccta     2580

tgggctatgg gcctcgtatg caacagcctt ccaaccaggg ccagttcctt cctcagactc     2640

agttcccatc acagggaatg aatgtaacaa atatcccttt ggctccgtcc agcggtcaag     2700

ctccagtgtc tcaagcacaa atgtctagtt cttcctgccc ggtgaactct cctataatgc     2760

ctccagggtc tcaggggagc cacattcact gtccccagct tcctcaacca gctcttcatc     2820

agaattcacc ctcgcctgta cctagtcgta cccccacccc tcaccatact cccccaagca     2880

taggggctca gcagccacca gcaacaacaa ttccagcccc tgttcctaca cctcctgcca     2940

tgccacctgg gccacagtcc caggctctac atccccctcc aaggcagaca cctacaccac     3000

caacaacaca acttccccaa caagtgcagc cttcacttcc tgctgcacct tctgctgacc     3060

agccccagca gcagcctcgc tcacagcaga gcacagcagc gtctgttcct accccaacag     3120

caccgctgct tcctccgcag cctgcaactc cactttccca gccagctgta agcattgaag     3180

gacaggtatc aaatcctcca tctactagta gcacagaagt gaattctcag gccattgctg     3240

agaagcagcc ttcccaggaa gtgaagatgg aggccaaaat ggaagtggat caaccagaac     3300

cagcagatac tcagccggag gatatttcag agtctaaagt ggaagactgt aaaatggaat     3360

ctaccgaaac agaagagaga agcactgagt taaaaactga aataaaagag gaggaagacc     3420

agccaagtac ttcagctacc cagtcatctc cggctccagg acagtcaaag aaaaagattt     3480

tcaaaccaga agaactacga caggcactga tgccaacttt ggaggcactt taccgtcagg     3540

atccagaatc ccttcccttt cgtcaacctg tggaccctca gcttttagga atccctgatt     3600

actttgatat tgtgaagagc cccatggatc tttctaccat taagaggaag ttagacactg     3660

gacagtatca ggagccctgg cagtatgtcg atgatatttg gcttatgttc aataatgcct     3720

ggttatataa ccggaaaaca tcacgggtat acaaatactg ctccaagctc tctgaggtct     3780

ttgaacaaga aattgaccca gtgatgcaaa gccttggata ctgttgtggc agaaagttgg     3840

agttctctcc acagacactg tgttgctacg gcaaacagtt gtgcacaata cctcgtgatg     3900

ccacttatta cagttaccag aacaggtatc atttctgtga gaagtgtttc aatgagatcc     3960

aaggggagag cgtttctttg ggggatgacc cttcccagcc tcaaactaca ataaataaag     4020

aacaattttc caagagaaaa aatgacacac tggatcctga actgtttgtt gaatgtacag     4080

agtgcggaag aaagatgcat cagatctgtg tccttcacca tgagatcatc tggcctgctg     4140

gattcgtctg tgatggctgt ttaaagaaaa gtgcacgaac taggaaagaa aataagtttt     4200

ctgctaaaag gttgccatct accagacttg gcacctttct agagaatcgt gtgaatgact     4260

ttctgaggcg acagaatcac cctgagtcag gagaggtcac tgttagagta gttcatgctt     4320

ctgacaaaac cgtggaagta aaaccaggca tgaaagcaag gtttgtggac agtggagaga     4380

tggcagaatc ctttccatac cgaaccaaag ccctctttgc ctttgaagaa attgatggtg     4440

ttgacctgtg cttctttggc atgcatgttc aagagtatgg ctctgactgc cctccaccca     4500

accagaggag agtatacata tcttacctcg atagtgttca tttcttccgt cctaaatgct     4560

tgaggactgc agtctatcat gaaatcctaa ttggatattt agaatatgtc aagaaattag     4620

gttacacaac agggcatatt tgggcatgtc caccaagtga gggagatgat tatatcttcc     4680

attgccatcc tcctgaccag aagataccca agcccaagcg actgcaggaa tggtacaaaa     4740

aaatgcttga caaggctgta tcagagcgta ttgtccatga ctacaaggat atttttaaac     4800

aagctactga agatagatta acaagtgcaa aggaattgcc ttatttcgag ggtgatttct     4860

ggcccaatgt tctggaagaa agcattaagg aactggaaca ggaggaagaa gagagaaaac     4920

gagaggaaaa caccagcaat gaaagcacag atgtgaccaa gggagacagc aaaaatgcta     4980

aaaagaagaa taataagaaa accagcaaaa ataagagcag cctgagtagg ggcaacaaga     5040

agaaacccgg gatgcccaat gtatctaacg acctctcaca gaaactatat gccaccatgg     5100

agaagcataa agaggtcttc tttgtgatcc gcctcattgc tggccctgct gccaactccc     5160

tgcctcccat tgttgatcct gatcctctca tcccctgcga tctgatggat ggtcgggatg     5220

cgtttctcac gctggcaagg gacaagcacc tggagttctc ttcactccga agagcccagt     5280

ggtccaccat gtgcatgctg gtggagctgc acacgcagag ccaggaccgc tttgtctaca     5340

cctgcaatga atgcaagcac catgtggaga cacgctggca ctgtactgtc tgtgaggatt     5400

atgacttgtg tatcacctgc tataacacta aaaaccatga ccacaaaatg gagaaactag     5460

gccttggctt agatgatgag agcaacaacc agcaggctgc agccacccag agcccaggcg     5520

attctcgccg cctgagtatc cagcgctgca tccagtctct ggtccatgct tgccagtgtc     5580

ggaatgccaa ttgctcactg ccatcctgcc agaagatgaa gcgggttgtg cagcatacca     5640

agggttgcaa acggaaaacc aatggcgggt gccccatctg caagcagctc attgccctct     5700

gctgctacca tgccaagcac tgccaggaga acaaatgccc ggtgccgttc tgcctaaaca     5760

tcaagcagaa gctccggcag caacagctgc agcaccgact acagcaggcc caaatgcttc     5820

gcaggaggat ggccagcatg cagcggactg gtgtggttgg gcagcaacag ggcctccctt     5880

cccccactcc tgccactcca acgacaccaa ctggccaaca gccaaccacc ccgcagacgc     5940

cccagcccac ttctcagcct cagcctaccc ctcccaatag catgccaccc tacttgccca     6000

ggactcaagc tgctggccct gtgtcccagg gtaaggcagc aggccaggtg acccctccaa     6060

cccctcctca gactgctcag ccaccccttc cagggccccc acctgcagca gtggaaatgg     6120

caatgcagat tcagagagca gcggagacgc agcgccagat ggcccacgtg caaatttttc     6180

aaaggccaat ccaacaccag atgcccccga tgactcccat ggcccccatg ggtatgaacc     6240

cacctcccat gaccagaggt cccagtgggc atttggagcc agggatggga ccgacaggga     6300

tgcagcaaca gccaccctgg agccaaggag gattgcctca gccccagcaa ctacagtctg     6360

ggatgccaag gccagccatg atgtcagtgg cccagcatgg tcaacctttg aacatggctc     6420

cacaaccagg attgggccag gtaggtatca gcccactcaa accaggcact gtgtctcaac     6480

aagccttaca aaaccttttg cggactctca ggtctcccag ctctcccctg cagcagcaac     6540

aggtgcttag tatccttcac gccaaccccc agctgttggc tgcattcatc aagcagcggg     6600

ctgccaagta tgccaactct aatccacaac ccatccctgg gcagcctggc atgccccagg     6660

ggcagccagg gctacagcca cctaccatgc caggtcagca gggggtccac tccaatccag     6720

ccatgcagaa catgaatcca atgcaggcgg gcgttcagag ggctggcctg ccccagcagc     6780

aaccacagca gcaactccag ccacccatgg gagggatgag cccccaggct cagcagatga     6840

acatgaacca caacaccatg ccttcacaat tccgagacat cttgagacga cagcaaatga     6900

tgcaacagca gcagcaacag ggagcagggc caggaatagg ccctggaatg gccaaccata     6960

accagttcca gcaaccccaa ggagttggct acccaccaca gcagcagcag cggatgcagc     7020

atcacatgca acagatgcaa caaggaaata tgggacagat aggccagctt ccccaggcct     7080

tgggagcaga ggcaggtgcc agtctacagg cctatcagca gcgactcctt cagcaacaga     7140

tggggtcccc tgttcagccc aaccccatga gcccccagca gcatatgctc ccaaatcagg     7200

cccagtcccc acacctacaa ggccagcaga tccctaattc tctctccaat caagtgcgct     7260

ctccccagcc tgtcccttct ccacggccac agtcccagcc cccccactcc agtccttccc     7320

caaggatgca gcctcagcct tctccacacc acgtttcccc acagacaagt tccccacatc     7380

ctggactggt agctgcccag gccaacccca tggaacaagg gcattttgcc agcccggacc     7440

agaattcaat gctttctcag cttgctagca atccaggcat ggcaaacctc catggtgcaa     7500

gcgccacgga cctgggactc agcaccgata actcagactt gaattcaaac ctctcacaga     7560

gtacactaga catacactag agacaccttg tagtattttg ggagcaaaaa aattattttc     7620

tcttaacaag actttttgta ctgaaaacaa tttttttgaa tctttcgtag cctaaaagac     7680

aattttcctt ggaacacata agaactgtgc agtagccgtt tgtggtttaa agcaaacatg     7740

caagatgaac ctgagggatg atagaataca aagaatatat ttttgttatg gctggttacc     7800

accagccttt cttccccttt gtgtgtgtgg ttcaagtgtg cactgggagg aggctgaggc     7860

ctgtgaagcc aaacaatatg ctcctgcctt gcacctccaa taggttttat tatttttttt     7920

aaattaatga acatatgtaa tattaatagt tattatttac tggtgcagat ggttgacatt     7980

tttccctatt ttcctcactt tatggaagag ttaaaacatt tctaaaccag aggacaaaag     8040

gggttaatgt tactttaaaa ttacattcta tatatatata aatatatata aatatatatt     8100

aaaataccag ttttttttct ctgggtgcaa agatgttcat tcttttaaaa aatgtttaaa     8160

aaaaaaaaaa aactgccttt cttcccctca agtcaacttt tgtgctccag aaaattttct     8220

attctgtaag tctgagcgta aaacttcaag tattaaaata atttgtacat gtagagagaa     8280

aaatgacttt ttcaaaaata tacaggggca gctgccaaat tgatgtatta tatattgtgg     8340

tttctgtttc ttgaaagaat ttttttcgtt atttttacat ctaacaaagt aaaaaaatta     8400

aaaagagggt aagaaacgat tccggtggga tgattttaac atgcaaaatg tccctggggg     8460

tttcttcttt gcttgctttc ttcctcctta ccctaccccc cactcacaca cacacacaca     8520

cacacacaca cacacacaca cacacacttt ctataaaact tgaaaatagc aaaaaccctc     8580

aactgttgta aatcatgcaa ttaaagttga ttacttataa atatgaactt tggatcactg     8640

tatagactgt taaatttgat ttcttattac ctattgttaa ataaactgtg tgagacagac     8700

a                                                                     8701


<210>  3
<211>  2191
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Ser Tyr Pro Glu Trp Thr Cys Trp Arg Gly Ser His Gln Met 
1               5                   10                  15      


Gly Ile Thr Gly Asn Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala 
            20                  25                  30          


Gly Gly Gln Pro Met Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser 
        35                  40                  45              


Lys Gln Ser Met Val Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys 
    50                  55                  60                  


Asn Thr Ser Val Thr Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser 
65                  70                  75                  80  


Val Gly Ile Val Pro Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp 
                85                  90                  95      


Pro Glu Lys Arg Lys Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His 
            100                 105                 110         


Ala His Lys Cys Gln Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala 
        115                 120                 125             


Cys Ser Leu Pro His Cys Arg Thr Met Lys Asn Val Leu Asn His Met 
    130                 135                 140                 


Thr His Cys Gln Ala Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser 
145                 150                 155                 160 


Ser Arg Gln Ile Ile Ser His Trp Lys Asn Cys Thr Arg His Asp Cys 
                165                 170                 175     


Pro Val Cys Leu Pro Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln 
            180                 185                 190         


Thr Ile Leu Gly Ser Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser 
        195                 200                 205             


Val Gly Thr Gly Gln Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro 
    210                 215                 220                 


Ile Asp Pro Ser Ser Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro 
225                 230                 235                 240 


Tyr Met Asn Gln Pro Gln Thr Gln Leu Gln Pro Gln Val Pro Gly Gln 
                245                 250                 255     


Gln Pro Ala Gln Pro Gln Thr His Gln Gln Met Arg Thr Leu Asn Pro 
            260                 265                 270         


Leu Gly Asn Asn Pro Met Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp 
        275                 280                 285             


Gln Gln Pro Pro Asn Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu 
    290                 295                 300                 


Gly Ala Thr Asn Pro Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile 
305                 310                 315                 320 


Gly Thr Leu Ser Thr Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly 
                325                 330                 335     


Val Arg Lys Gly Trp His Glu His Val Thr Gln Asp Leu Arg Ser His 
            340                 345                 350         


Leu Val His Lys Leu Val Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala 
        355                 360                 365             


Ala Leu Lys Asp Arg Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys 
    370                 375                 380                 


Val Glu Gly Asp Met Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr 
385                 390                 395                 400 


His Leu Leu Ala Glu Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu 
                405                 410                 415     


Lys Arg Arg Ser Arg Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro 
            420                 425                 430         


Ala Leu Pro Ala Pro Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln 
        435                 440                 445             


Pro Val Arg Pro Pro Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met 
    450                 455                 460                 


Gln Val Ser Gln Gly Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn 
465                 470                 475                 480 


Val Gln Leu Pro Gln Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met 
                485                 490                 495     


Asn His Ser Val Gln Met Asn Ser Met Gly Ser Val Pro Gly Met Ala 
            500                 505                 510         


Ile Ser Pro Ser Arg Met Pro Gln Pro Pro Asn Met Met Gly Ala His 
        515                 520                 525             


Thr Asn Asn Met Met Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro 
    530                 535                 540                 


Gln Asn Gln Phe Pro Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly 
545                 550                 555                 560 


Gln Pro Pro Ala Gln Thr Gly Val Ser Gln Gly Gln Val Pro Gly Ala 
                565                 570                 575     


Ala Leu Pro Asn Pro Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu 
            580                 585                 590         


Pro Cys Pro Pro Val Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro 
        595                 600                 605             


Ala Ser Thr Ala Ala Gly Met Pro Ser Leu Gln His Thr Thr Pro Pro 
    610                 615                 620                 


Gly Met Thr Pro Pro Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro 
625                 630                 635                 640 


Val Ser Ser Ser Gly Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro 
                645                 650                 655     


Ser Ala Thr Gln Thr Gln Ser Thr Pro Thr Val Gln Ala Ala Ala Gln 
            660                 665                 670         


Ala Gln Val Thr Pro Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val 
        675                 680                 685             


Ala Thr Pro Gln Ser Ser Gln Gln Gln Pro Thr Pro Val His Ala Gln 
    690                 695                 700                 


Pro Pro Gly Thr Pro Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg 
705                 710                 715                 720 


Val Pro Thr Pro Ser Ser Val Ala Ser Ala Glu Thr Asn Ser Gln Gln 
                725                 730                 735     


Pro Gly Pro Asp Val Pro Val Leu Glu Met Lys Thr Glu Thr Gln Ala 
            740                 745                 750         


Glu Asp Thr Glu Pro Asp Pro Gly Glu Ser Lys Gly Glu Pro Arg Ser 
        755                 760                 765             


Glu Met Met Glu Glu Asp Leu Gln Gly Ala Ser Gln Val Lys Glu Glu 
    770                 775                 780                 


Thr Asp Ile Ala Glu Gln Lys Ser Glu Pro Met Glu Val Asp Glu Lys 
785                 790                 795                 800 


Lys Pro Glu Val Lys Val Glu Val Lys Glu Glu Glu Glu Ser Ser Ser 
                805                 810                 815     


Asn Gly Thr Ala Ser Gln Ser Thr Ser Pro Ser Gln Pro Arg Lys Lys 
            820                 825                 830         


Ile Phe Lys Pro Glu Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu 
        835                 840                 845             


Ala Leu Tyr Arg Gln Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val 
    850                 855                 860                 


Asp Pro Gln Leu Leu Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Asn 
865                 870                 875                 880 


Pro Met Asp Leu Ser Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr 
                885                 890                 895     


Gln Glu Pro Trp Gln Tyr Val Asp Asp Val Trp Leu Met Phe Asn Asn 
            900                 905                 910         


Ala Trp Leu Tyr Asn Arg Lys Thr Ser Arg Val Tyr Lys Phe Cys Ser 
        915                 920                 925             


Lys Leu Ala Glu Val Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser 
    930                 935                 940                 


Leu Gly Tyr Cys Cys Gly Arg Lys Tyr Glu Phe Ser Pro Gln Thr Leu 
945                 950                 955                 960 


Cys Cys Tyr Gly Lys Gln Leu Cys Thr Ile Pro Arg Asp Ala Ala Tyr 
                965                 970                 975     


Tyr Ser Tyr Gln Asn Arg Tyr His Phe Cys Glu Lys Cys Phe Thr Glu 
            980                 985                 990         


Ile Gln Gly Glu Asn Val Thr Leu  Gly Asp Asp Pro Ser  Gln Pro Gln 
        995                 1000                 1005             


Thr Thr  Ile Ser Lys Asp Gln  Phe Glu Lys Lys Lys  Asn Asp Thr 
    1010                 1015                 1020             


Leu Asp  Pro Glu Pro Phe Val  Asp Cys Lys Glu Cys  Gly Arg Lys 
    1025                 1030                 1035             


Met His  Gln Ile Cys Val Leu  His Tyr Asp Ile Ile  Trp Pro Ser 
    1040                 1045                 1050             


Gly Phe  Val Cys Asp Asn Cys  Leu Lys Lys Thr Gly  Arg Pro Arg 
    1055                 1060                 1065             


Lys Glu  Asn Lys Phe Ser Ala  Lys Arg Leu Gln Thr  Thr Arg Leu 
    1070                 1075                 1080             


Gly Asn  His Leu Glu Asp Arg  Val Asn Lys Phe Leu  Arg Arg Gln 
    1085                 1090                 1095             


Asn His  Pro Glu Ala Gly Glu  Val Phe Val Arg Val  Val Ala Ser 
    1100                 1105                 1110             


Ser Asp  Lys Thr Val Glu Val  Lys Pro Gly Met Lys  Ser Arg Phe 
    1115                 1120                 1125             


Val Asp  Ser Gly Glu Met Ser  Glu Ser Phe Pro Tyr  Arg Thr Lys 
    1130                 1135                 1140             


Ala Leu  Phe Ala Phe Glu Glu  Ile Asp Gly Val Asp  Val Cys Phe 
    1145                 1150                 1155             


Phe Gly  Met His Val Gln Glu  Tyr Gly Ser Asp Cys  Pro Pro Pro 
    1160                 1165                 1170             


Asn Thr  Arg Arg Val Tyr Ile  Ser Tyr Leu Asp Ser  Ile His Phe 
    1175                 1180                 1185             


Phe Arg  Pro Arg Cys Leu Arg  Thr Ala Val Tyr His  Glu Ile Leu 
    1190                 1195                 1200             


Ile Gly  Tyr Leu Glu Tyr Val  Lys Lys Leu Gly Tyr  Val Thr Gly 
    1205                 1210                 1215             


His Ile  Trp Ala Cys Pro Pro  Ser Glu Gly Asp Asp  Tyr Ile Phe 
    1220                 1225                 1230             


His Cys  His Pro Pro Asp Gln  Lys Ile Pro Lys Pro  Lys Arg Leu 
    1235                 1240                 1245             


Gln Glu  Trp Tyr Lys Lys Met  Leu Asp Lys Ala Phe  Ala Glu Arg 
    1250                 1255                 1260             


Ile Ile  His Asp Tyr Lys Asp  Ile Phe Lys Gln Ala  Thr Glu Asp 
    1265                 1270                 1275             


Arg Leu  Thr Ser Ala Lys Glu  Leu Pro Tyr Phe Glu  Gly Asp Phe 
    1280                 1285                 1290             


Trp Pro  Asn Val Leu Glu Glu  Ser Ile Lys Glu Leu  Glu Gln Glu 
    1295                 1300                 1305             


Glu Glu  Glu Arg Lys Lys Glu  Glu Ser Thr Ala Ala  Ser Glu Thr 
    1310                 1315                 1320             


Thr Glu  Gly Ser Gln Gly Asp  Ser Lys Asn Ala Lys  Lys Lys Asn 
    1325                 1330                 1335             


Asn Lys  Lys Thr Asn Lys Asn  Lys Ser Ser Ile Ser  Arg Ala Asn 
    1340                 1345                 1350             


Lys Lys  Lys Pro Ser Met Pro  Asn Val Ser Asn Asp  Leu Ser Gln 
    1355                 1360                 1365             


Lys Leu  Tyr Ala Thr Met Glu  Lys His Lys Glu Val  Phe Phe Val 
    1370                 1375                 1380             


Ile His  Leu His Ala Gly Pro  Val Ile Asn Thr Leu  Pro Pro Ile 
    1385                 1390                 1395             


Val Asp  Pro Asp Pro Leu Leu  Ser Cys Asp Leu Met  Asp Gly Arg 
    1400                 1405                 1410             


Asp Ala  Phe Leu Thr Leu Ala  Arg Asp Lys His Trp  Glu Phe Ser 
    1415                 1420                 1425             


Ser Leu  Arg Arg Ser Lys Trp  Ser Thr Leu Cys Met  Leu Val Glu 
    1430                 1435                 1440             


Leu His  Thr Gln Gly Gln Asp  Arg Phe Val Tyr Thr  Cys Asn Glu 
    1445                 1450                 1455             


Cys Lys  His His Val Glu Thr  Arg Trp His Cys Thr  Val Cys Glu 
    1460                 1465                 1470             


Asp Tyr  Asp Leu Cys Ile Asn  Cys Tyr Asn Thr Lys  Ser His Ala 
    1475                 1480                 1485             


His Lys  Met Val Lys Trp Gly  Leu Gly Leu Asp Asp  Glu Gly Ser 
    1490                 1495                 1500             


Ser Gln  Gly Glu Pro Gln Ser  Lys Ser Pro Gln Glu  Ser Arg Arg 
    1505                 1510                 1515             


Leu Ser  Ile Gln Arg Cys Ile  Gln Ser Leu Val His  Ala Cys Gln 
    1520                 1525                 1530             


Cys Arg  Asn Ala Asn Cys Ser  Leu Pro Ser Cys Gln  Lys Met Lys 
    1535                 1540                 1545             


Arg Val  Val Gln His Thr Lys  Gly Cys Lys Arg Lys  Thr Asn Gly 
    1550                 1555                 1560             


Gly Cys  Pro Val Cys Lys Gln  Leu Ile Ala Leu Cys  Cys Tyr His 
    1565                 1570                 1575             


Ala Lys  His Cys Gln Glu Asn  Lys Cys Pro Val Pro  Phe Cys Leu 
    1580                 1585                 1590             


Asn Ile  Lys His Lys Leu Arg  Gln Gln Gln Ile Gln  His Arg Leu 
    1595                 1600                 1605             


Gln Gln  Ala Gln Leu Met Arg  Arg Arg Met Ala Thr  Met Asn Thr 
    1610                 1615                 1620             


Arg Asn  Val Pro Gln Gln Ser  Leu Pro Ser Pro Thr  Ser Ala Pro 
    1625                 1630                 1635             


Pro Gly  Thr Pro Thr Gln Gln  Pro Ser Thr Pro Gln  Thr Pro Gln 
    1640                 1645                 1650             


Pro Pro  Ala Gln Pro Gln Pro  Ser Pro Val Ser Met  Ser Pro Ala 
    1655                 1660                 1665             


Gly Phe  Pro Ser Val Ala Arg  Thr Gln Pro Pro Thr  Thr Val Ser 
    1670                 1675                 1680             


Thr Gly  Lys Pro Thr Ser Gln  Val Pro Ala Pro Pro  Pro Pro Ala 
    1685                 1690                 1695             


Gln Pro  Pro Pro Ala Ala Val  Glu Ala Ala Arg Gln  Ile Glu Arg 
    1700                 1705                 1710             


Glu Ala  Gln Gln Gln Gln His  Leu Tyr Arg Val Asn  Ile Asn Asn 
    1715                 1720                 1725             


Ser Met  Pro Pro Gly Arg Thr  Gly Met Gly Thr Pro  Gly Ser Gln 
    1730                 1735                 1740             


Met Ala  Pro Val Ser Leu Asn  Val Pro Arg Pro Asn  Gln Val Ser 
    1745                 1750                 1755             


Gly Pro  Val Met Pro Ser Met  Pro Pro Gly Gln Trp  Gln Gln Ala 
    1760                 1765                 1770             


Pro Leu  Pro Gln Gln Gln Pro  Met Pro Gly Leu Pro  Arg Pro Val 
    1775                 1780                 1785             


Ile Ser  Met Gln Ala Gln Ala  Ala Val Ala Gly Pro  Arg Met Pro 
    1790                 1795                 1800             


Ser Val  Gln Pro Pro Arg Ser  Ile Ser Pro Ser Ala  Leu Gln Asp 
    1805                 1810                 1815             


Leu Leu  Arg Thr Leu Lys Ser  Pro Ser Ser Pro Gln  Gln Gln Gln 
    1820                 1825                 1830             


Gln Val  Leu Asn Ile Leu Lys  Ser Asn Pro Gln Leu  Met Ala Ala 
    1835                 1840                 1845             


Phe Ile  Lys Gln Arg Thr Ala  Lys Tyr Val Ala Asn  Gln Pro Gly 
    1850                 1855                 1860             


Met Gln  Pro Gln Pro Gly Leu  Gln Ser Gln Pro Gly  Met Gln Pro 
    1865                 1870                 1875             


Gln Pro  Gly Met His Gln Gln  Pro Ser Leu Gln Asn  Leu Asn Ala 
    1880                 1885                 1890             


Met Gln  Ala Gly Val Pro Arg  Pro Gly Val Pro Pro  Gln Gln Gln 
    1895                 1900                 1905             


Ala Met  Gly Gly Leu Asn Pro  Gln Gly Gln Ala Leu  Asn Ile Met 
    1910                 1915                 1920             


Asn Pro  Gly His Asn Pro Asn  Met Ala Ser Met Asn  Pro Gln Tyr 
    1925                 1930                 1935             


Arg Glu  Met Leu Arg Arg Gln  Leu Leu Gln Gln Gln  Gln Gln Gln 
    1940                 1945                 1950             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gly Ser Ala 
    1955                 1960                 1965             


Gly Met  Ala Gly Gly Met Ala  Gly His Gly Gln Phe  Gln Gln Pro 
    1970                 1975                 1980             


Gln Gly  Pro Gly Gly Tyr Pro  Pro Ala Met Gln Gln  Gln Gln Arg 
    1985                 1990                 1995             


Met Gln  Gln His Leu Pro Leu  Gln Gly Ser Ser Met  Gly Gln Met 
    2000                 2005                 2010             


Ala Ala  Gln Met Gly Gln Leu  Gly Gln Met Gly Gln  Pro Gly Leu 
    2015                 2020                 2025             


Gly Ala  Asp Ser Thr Pro Asn  Ile Gln Gln Ala Leu  Gln Gln Arg 
    2030                 2035                 2040             


Ile Leu  Gln Gln Gln Gln Met  Lys Gln Gln Ile Gly  Ser Pro Gly 
    2045                 2050                 2055             


Gln Pro  Asn Pro Met Ser Pro  Gln Gln His Met Leu  Ser Gly Gln 
    2060                 2065                 2070             


Pro Gln  Ala Ser His Leu Pro  Gly Gln Gln Ile Ala  Thr Ser Leu 
    2075                 2080                 2085             


Ser Asn  Gln Val Arg Ser Pro  Ala Pro Val Gln Ser  Pro Arg Pro 
    2090                 2095                 2100             


Gln Ser  Gln Pro Pro His Ser  Ser Pro Ser Pro Arg  Ile Gln Pro 
    2105                 2110                 2115             


Gln Pro  Ser Pro His His Val  Ser Pro Gln Thr Gly  Ser Pro His 
    2120                 2125                 2130             


Pro Gly  Leu Ala Val Thr Met  Ala Ser Ser Ile Asp  Gln Gly His 
    2135                 2140                 2145             


Leu Gly  Asn Pro Glu Gln Ser  Ala Met Leu Pro Gln  Leu Asn Thr 
    2150                 2155                 2160             


Pro Ser  Arg Ser Ala Leu Ser  Ser Glu Leu Ser Leu  Val Gly Asp 
    2165                 2170                 2175             


Thr Thr  Gly Asp Thr Leu Glu  Lys Phe Val Glu Gly  Leu 
    2180                 2185                 2190     


<210>  4
<211>  9674
<212>  DNA
<213>  Homo sapiens

<400>  4
cagatgacag ttgaaggaag cttcttgcaa atcagaaatg tgcttaatat ttatcgagct       60

accatcttgc ctagattaag tcatttgaac tcgaaattga gtctggtttg tggacttgca      120

gaagaattag tgtctcagtt cacttaagta gagcacctag tggtgacaag aatgtgattg      180

ctttccaaaa ggtgagaaat gtcacctagg aggactacat ggggaaggaa atcacctgcg      240

tatgaaatgc acagagctag aactttctgg ttatactcct ttggttttta tttgtgtttc      300

tgtacaggca tttcagcaga aagggccagt tgtgttgagt gttgatttgt ttgtagccta      360

gacttttaga gctgaaagaa ataatacgat ccatcttgtt caagacactc atcttacagg      420

cgaggagttt gaagtccata gaaggaatgt taagttaccc agagtggaca tgctggcgtg      480

gcagtcacca gatgggaata actgggaaca caagtccatt tggacagccc tttagtcaag      540

ctggagggca gccaatggga gccactggag tgaaccccca gttagccagc aaacagagca      600

tggtcaacag tttgcccacc ttccctacag atatcaagaa tacttcagtc accaacgtgc      660

caaatatgtc tcagatgcaa acatcagtgg gaattgtacc cacacaagca attgcaacag      720

gccccactgc agatcctgaa aaacgcaaac tgatacagca gcagctggtt ctactgcttc      780

atgctcataa gtgtcagaga cgagagcaag caaacggaga ggttcgggcc tgctcgctcc      840

cgcattgtcg aaccatgaaa aacgttttga atcacatgac gcattgtcag gctgggaaag      900

cctgccaagt tgcccattgt gcatcttcac gacaaatcat ctctcattgg aagaactgca      960

cacgacatga ctgtcctgtt tgcctccctt tgaaaaatgc cagtgacaag cgaaaccaac     1020

aaaccatcct ggggtctcca gctagtggaa ttcaaaacac aattggttct gttggcacag     1080

ggcaacagaa tgccacttct ttaagtaacc caaatcccat agaccccagc tccatgcagc     1140

gagcctatgc tgctctcgga ctcccctaca tgaaccagcc ccagacgcag ctgcagcctc     1200

aggttcctgg ccagcaacca gcacagcctc aaacccacca gcagatgagg actctcaacc     1260

ccctgggaaa taatccaatg aacattccag caggaggaat aacaacagat cagcagcccc     1320

caaacttgat ttcagaatca gctcttccga cttccctggg ggccacaaac ccactgatga     1380

acgatggctc caactctggt aacattggaa ccctcagcac tataccaaca gcagctcctc     1440

cttctagcac cggtgtaagg aaaggctggc acgaacatgt cactcaggac ctgcggagcc     1500

atctagtgca taaactcgtc caagccatct tcccaacacc tgatcccgca gctctaaagg     1560

atcgccgcat ggaaaacctg gtagcctatg ctaagaaagt ggaaggggac atgtacgagt     1620

ctgccaacag cagggatgaa tattatcact tattagcaga gaaaatctac aagatacaaa     1680

aagaactaga agaaaaacgg aggtcgcgtt tacataaaca aggcatcttg gggaaccagc     1740

cagccttacc agccccgggg gctcagcccc ctgtgattcc acaggcacaa cctgtgagac     1800

ctccaaatgg acccctgtcc ctgccagtga atcgcatgca agtttctcaa gggatgaatt     1860

catttaaccc catgtccttg gggaacgtcc agttgccaca agcacccatg ggacctcgtg     1920

cagcctcccc aatgaaccac tctgtccaga tgaacagcat gggctcagtg ccagggatgg     1980

ccatttctcc ttcccgaatg cctcagcctc cgaacatgat gggtgcacac accaacaaca     2040

tgatggccca ggcgcccgct cagagccagt ttctgccaca gaaccagttc ccgtcatcca     2100

gcggggcgat gagtgtgggc atggggcagc cgccagccca aacaggcgtg tcacagggac     2160

aggtgcctgg tgctgctctt cctaaccctc tcaacatgct ggggcctcag gccagccagc     2220

taccttgccc tccagtgaca cagtcaccac tgcacccaac accgcctcct gcttccacgg     2280

ctgctggcat gccatctctc cagcacacga caccacctgg gatgactcct ccccagccag     2340

cagctcccac tcagccatca actcctgtgt cgtcttccgg gcagactccc accccgactc     2400

ctggctcagt gcccagtgct acccaaaccc agagcacccc tacagtccag gcagcagccc     2460

aggcccaggt gaccccgcag cctcaaaccc cagttcagcc cccgtctgtg gctacccctc     2520

agtcatcgca gcaacagccg acgcctgtgc acgcccagcc tcctggcaca ccgctttccc     2580

aggcagcagc cagcattgat aacagagtcc ctaccccctc ctcggtggcc agcgcagaaa     2640

ccaattccca gcagccagga cctgacgtac ctgtgctgga aatgaagacg gagacccaag     2700

cagaggacac tgagcccgat cctggtgaat ccaaagggga gcccaggtct gagatgatgg     2760

aggaggattt gcaaggagct tcccaagtta aagaagaaac agacatagca gagcagaaat     2820

cagaaccaat ggaagtggat gaaaagaaac ctgaagtgaa agtagaagtt aaagaggaag     2880

aagagagtag cagtaacggc acagcctctc agtcaacatc tccttcgcag ccgcgcaaaa     2940

aaatctttaa accagaggag ttacgccagg ccctcatgcc aaccctagaa gcactgtatc     3000

gacaggaccc agagtcatta cctttccggc agcctgtaga tccccagctc ctcggaattc     3060

cagactattt tgacatcgta aagaatccca tggacctctc caccatcaag cggaagctgg     3120

acacagggca ataccaagag ccctggcagt acgtggacga cgtctggctc atgttcaaca     3180

atgcctggct ctataatcgc aagacatccc gagtctataa gttttgcagt aagcttgcag     3240

aggtctttga gcaggaaatt gaccctgtca tgcagtccct tggatattgc tgtggacgca     3300

agtatgagtt ttccccacag actttgtgct gctatgggaa gcagctgtgt accattcctc     3360

gcgatgctgc ctactacagc tatcagaata ggtatcattt ctgtgagaag tgtttcacag     3420

agatccaggg cgagaatgtg accctgggtg acgacccttc acagccccag acgacaattt     3480

caaaggatca gtttgaaaag aagaaaaatg ataccttaga ccccgaacct ttcgttgatt     3540

gcaaggagtg tggccggaag atgcatcaga tttgcgttct gcactatgac atcatttggc     3600

cttcaggttt tgtgtgcgac aactgcttga agaaaactgg cagacctcga aaagaaaaca     3660

aattcagtgc taagaggctg cagaccacaa gactgggaaa ccacttggaa gaccgagtga     3720

acaaattttt gcggcgccag aatcaccctg aagccgggga ggtttttgtc cgagtggtgg     3780

ccagctcaga caagacggtg gaggtcaagc ccgggatgaa gtcacggttt gtggattctg     3840

gggaaatgtc tgaatctttc ccatatcgaa ccaaagctct gtttgctttt gaggaaattg     3900

acggcgtgga tgtctgcttt tttggaatgc acgtccaaga atacggctct gattgccccc     3960

ctccaaacac gaggcgtgtg tacatttctt atctggatag tattcatttc ttccggccac     4020

gttgcctccg cacagccgtt taccatgaga tccttattgg atatttagag tatgtgaaga     4080

aattagggta tgtgacaggg cacatctggg cctgtcctcc aagtgaagga gatgattaca     4140

tcttccattg ccacccacct gatcaaaaaa tacccaagcc aaaacgactg caggagtggt     4200

acaaaaagat gctggacaag gcgtttgcag agcggatcat ccatgactac aaggatattt     4260

tcaaacaagc aactgaagac aggctcacca gtgccaagga actgccctat tttgaaggtg     4320

atttctggcc caatgtgtta gaagagagca ttaaggaact agaacaagaa gaagaggaga     4380

ggaaaaagga agagagcact gcagccagtg aaaccactga gggcagtcag ggcgacagca     4440

agaatgccaa gaagaagaac aacaagaaaa ccaacaagaa caaaagcagc atcagccgcg     4500

ccaacaagaa gaagcccagc atgcccaacg tgtccaatga cctgtcccag aagctgtatg     4560

ccaccatgga gaagcacaag gaggtcttct tcgtgatcca cctgcacgct gggcctgtca     4620

tcaacaccct gccccccatc gtcgaccccg accccctgct cagctgtgac ctcatggatg     4680

ggcgcgacgc cttcctcacc ctcgccagag acaagcactg ggagttctcc tccttgcgcc     4740

gctccaagtg gtccacgctc tgcatgctgg tggagctgca cacccagggc caggaccgct     4800

ttgtctacac ctgcaacgag tgcaagcacc acgtggagac gcgctggcac tgcactgtgt     4860

gcgaggacta cgacctctgc atcaactgct ataacacgaa gagccatgcc cataagatgg     4920

tgaagtgggg gctgggcctg gatgacgagg gcagcagcca gggcgagcca cagtcaaaga     4980

gcccccagga gtcacgccgg ctgagcatcc agcgctgcat ccagtcgctg gtgcacgcgt     5040

gccagtgccg caacgccaac tgctcgctgc catcctgcca gaagatgaag cgggtggtgc     5100

agcacaccaa gggctgcaaa cgcaagacca acgggggctg cccggtgtgc aagcagctca     5160

tcgccctctg ctgctaccac gccaagcact gccaagaaaa caaatgcccc gtgcccttct     5220

gcctcaacat caaacacaag ctccgccagc agcagatcca gcaccgcctg cagcaggccc     5280

agctcatgcg ccggcggatg gccaccatga acacccgcaa cgtgcctcag cagagtctgc     5340

cttctcctac ctcagcaccg cccgggaccc ccacacagca gcccagcaca ccccagacgc     5400

cgcagccccc tgcccagccc caaccctcac ccgtgagcat gtcaccagct ggcttcccca     5460

gcgtggcccg gactcagccc cccaccacgg tgtccacagg gaagcctacc agccaggtgc     5520

cggccccccc acccccggcc cagccccctc ctgcagcggt ggaagcggct cggcagatcg     5580

agcgtgaggc ccagcagcag cagcacctgt accgggtgaa catcaacaac agcatgcccc     5640

caggacgcac gggcatgggg accccgggga gccagatggc ccccgtgagc ctgaatgtgc     5700

cccgacccaa ccaggtgagc gggcccgtca tgcccagcat gcctcccggg cagtggcagc     5760

aggcgcccct tccccagcag cagcccatgc caggcttgcc caggcctgtg atatccatgc     5820

aggcccaggc ggccgtggct gggccccgga tgcccagcgt gcagccaccc aggagcatct     5880

cacccagcgc tctgcaagac ctgctgcgga ccctgaagtc gcccagctcc cctcagcagc     5940

aacagcaggt gctgaacatt ctcaaatcaa acccgcagct aatggcagct ttcatcaaac     6000

agcgcacagc caagtacgtg gccaatcagc ccggcatgca gccccagcct ggcctccagt     6060

cccagcccgg catgcaaccc cagcctggca tgcaccagca gcccagcctg cagaacctga     6120

atgccatgca ggctggcgtg ccgcggcccg gtgtgcctcc acagcagcag gcgatgggag     6180

gcctgaaccc ccagggccag gccttgaaca tcatgaaccc aggacacaac cccaacatgg     6240

cgagtatgaa tccacagtac cgagaaatgt tacggaggca gctgctgcag cagcagcagc     6300

aacagcagca gcaacaacag cagcaacagc agcagcagca agggagtgcc ggcatggctg     6360

ggggcatggc ggggcacggc cagttccagc agcctcaagg acccggaggc tacccaccgg     6420

ccatgcagca gcagcagcgc atgcagcagc atctccccct ccagggcagc tccatgggcc     6480

agatggcggc tcagatggga cagcttggcc agatggggca gccggggctg ggggcagaca     6540

gcacccccaa catccagcaa gccctgcagc agcggattct gcagcaacag cagatgaagc     6600

agcagattgg gtccccaggc cagccgaacc ccatgagccc ccagcaacac atgctctcag     6660

gacagccaca ggcctcgcat ctccctggcc agcagatcgc cacgtccctt agtaaccagg     6720

tgcggtctcc agcccctgtc cagtctccac ggccccagtc ccagcctcca cattccagcc     6780

cgtcaccacg gatacagccc cagccttcgc cacaccacgt ctcaccccag actggttccc     6840

cccaccccgg actcgcagtc accatggcca gctccataga tcagggacac ttggggaacc     6900

ccgaacagag tgcaatgctc ccccagctga acacccccag caggagtgcg ctgtccagcg     6960

aactgtccct ggtcggggac accacggggg acacgctaga gaagtttgtg gagggcttgt     7020

agcattgtga gagcatcacc ttttcccttt catgttcttg gaccttttgt actgaaaatc     7080

caggcatcta ggttcttttt attcctagat ggaactgcga cttccgagcc atggaagggt     7140

ggattgatgt ttaaagaaac aatacaaaga atatattttt ttgttaaaaa ccagttgatt     7200

taaatatctg gtctctctct ttggtttttt tttggcgggg gggtgggggg ggttcttttt     7260

tttccgtttt gtttttgttt ggggggaggg gggttttgtt tggattcttt ttgtcgtcat     7320

tgctggtgac tcatgccttt ttttaacggg aaaaacaagt tcattatatt catatttttt     7380

atttgtattt tcaagacttt aaacatttat gtttaaaagt aagaagaaaa ataatattca     7440

gaactgattc ctgaaataat gcaagcttat aatgtatccc gataactttg tgatgtttcg     7500

ggaagatttt tttctatagt gaactctgtg ggcgtctccc agtattaccc tggatgatag     7560

gaattgactc cggcgtgcac acacgtacac acccacacac atctatctat acataatggc     7620

tgaagccaaa cttgtcttgc agatgtagaa attgttgctt tgtttctctg ataaaactgg     7680

ttttagacaa aaaataggga tgatcactct tagaccatgc taatgttact agagaagaag     7740

ccttcttttc tttcttctat gtgaaacttg aaatgaggaa aagcaattct agtgtaaatc     7800

atgcaagcgc tctaattcct ataaatacga aactcgagaa gattcaatca ctgtatagaa     7860

tggtaaaata ccaactcatt tcttatatca tattgttaaa taaactgtgt gcaacagaca     7920

aaaagggtgg tccttcttga attcatgtac atggtattaa cacttagtgt tcggggtttt     7980

ttgttatgaa aatgctgttt tcaacattgt atttggacta tgcatgtgtt ttttccccat     8040

tgtatataaa gtaccgctta aaattgatat aaattactga ggtttttaac atgtattctg     8100

ttctttaaga tccctgtaag aatgtttaag gtttttattt atttatatat attttttgag     8160

tctgttcttt gtaagacatg gttctggttg ttcgctcata gcggagaggc tggggctgcg     8220

gttgtggttg tggcggcgtg ggtggtggct gggaactgtg gcccaggctt agcggccgcc     8280

cggaggcttt tcttcccgga gactgaggtg ggcgactgag gtgggcggct cagcgttggc     8340

cccacacatt cgaggctcac aggtgattgt cgctcacaca gttagggtcg tcagttggtc     8400

tgaaactgca tttggcccac tcctccatcc tccctgtccg tcgtagctgc cacccccaga     8460

ggcggcgctt cttcccgtgt tcaggcggct cccccccccc gtacacgact cccagaatct     8520

gaggcagaga gtgctccagg ctcgcgaggt gctttctgac ttccccccaa atcctgccgc     8580

tgccgcgcag catgtcccgt gtggcgtttg aggaaatgct gagggacaga caccttggag     8640

caccagctcc ggtccctgtt acagtgagaa aggtccccca cttcggggga tacttgcact     8700

tagccacatg gtcctgcctc ccttggagtc cagttccagg ctcccttact gagtgggtga     8760

gacaagttca caaaaaccgt aaaactgaga ggaggaccat gggcagggga gctgaagttc     8820

atcccctaag tctaccaccc ccagcaccca gagaacccac tttatcccta gtcccccaac     8880

aaaggctggt ctaggtgggg gtgatggtaa ttttagaaat cacgccccaa atagcttccg     8940

tttgggccct tacattcaca gataggtttt aaatagctga atacttggtt tgggaatctg     9000

aattcgagga acctttctaa gaagttggaa aggtccgatc tagttttagc acagagcttt     9060

gaaccttgag ttataaaatg cagaataatt caagtaaaaa taagaccacc atctggcacc     9120

cctgaccagc ccccattcac cccatcccag gaggggaagc acaggccggg cctccggtgg     9180

agattgctgc cactgctcgg cctgctgggt tcttaacctc cagtgtcctc ttcatctttt     9240

ccacccgtag ggaaaccttg agccatgtgt tcaaacaaga agtggggcta gagcccgaga     9300

gcagcagctc taagcccaca ctcagaaagt ggcgccctcc tggttgtgca gccttttaat     9360

gtgggcagtg gaggggcctc tgtttcaggt tatcctggaa ttcaaaacgt tatgtaccaa     9420

cctcatcctc tttggagtct gcatcctgtg caaccgtctt gggcaatcca gatgtcgaag     9480

gatgtgaccg agagcatggt ctgtggatgc taaccctaag tttgtcgtaa ggaaatttct     9540

gtaagaaacc tggaaagccc caacgctgtg tctcatgctg tatacttaag aggagaagaa     9600

aaagtcctat atttgtgatc aaaaagagga aacttgaaat gtgatggtgt ttataataaa     9660

agatggtaaa acta                                                       9674


<210>  5
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser 
            180                 185                 190         


Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe 
        195                 200                 205             


Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp 
    210                 215                 220                 


Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp 
225                 230                 235                 240 


Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg 
                245                 250                 255     


Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser 
            260                 265                 270         


Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu 
        275                 280                 285             


Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala 
    290                 295                 300                 


Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser 
305                 310                 315                 320 


Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu 
                325                 330                 335     


Ile Phe Arg Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser 
            340                 345                 350         


His Ile Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln 
        355                 360                 365             


Lys Phe Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp 
    370                 375                 380                 


Thr Glu Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
385                 390                 395             


<210>  6
<211>  3586
<212>  DNA
<213>  Homo sapiens

<400>  6
gcgggtaaac agacatggcc ggcgaaggag atcagcagga cgctgcgcac aacatgggca       60

accacctgcc gctcctgcct gcagagagtg aggaagaaga tgaaatggaa gttgaagacc      120

aggatagtaa agaagccaaa aaaccaaaca tcataaattt tgacaccagt ctgccgacat      180

cacatacata cctaggtgct gatatggaag aatttcatgg caggactttg cacgatgacg      240

acagctgtca ggtgattcca gttcttccac aagtgatgat gatcctgatt cccggacaga      300

cattacctct tcagcttttt caccctcaag aagtcagtat ggtgcggaat ttaattcaga      360

aagatagaac ctttgctgtt cttgcataca gcaatgtaca ggaaagggaa gcacagtttg      420

gaacaacagc agagatatat gcctatcgag aagaacagga ttttggaatt gagatagtga      480

aagtgaaagc aattggaaga caaaggttca aagtccttga gctaagaaca cagtcagatg      540

gaatccagca agctaaagtg caaattcttc ccgaatgtgt gttgccttca accatgtctg      600

cagttcaatt agaatccctc aataagtgcc agatatttcc ttcaaaacct gtctcaagag      660

aagaccaatg ttcatataaa tggtggcaga aataccagaa gagaaagttt cattgtgcaa      720

atctaacttc atggcctcgc tggctgtatt ccttatatga tgctgagacc ttaatggaca      780

gaatcaagaa acagctacgt gaatgggatg aaaatctaaa agatgattct cttccttcaa      840

atccaataga tttttcttac agagtagctg cttgtcttcc tattgatgat gtattgagaa      900

ttcagctcct taaaattggc agtgctatcc agcgacttcg ctgtgaatta gacattatga      960

ataaatgtac ttccctttgc tgtaaacaat gtcaagaaac agaaataaca accaaaaatg     1020

aaatattcag gtatgcctgg actgttgccc agtgtaagat ctgtgcaagc catattggat     1080

ggaagtttac ggccaccaaa aaagacatgt cacctcaaaa attttggggc ttaacgcgat     1140

ctgctctgtt gcccacgatc ccagacactg aagatgaaat aagtccagac aaagtaatac     1200

tttgcttgta aacagatgtg atagagataa agttatctaa caaattggtt atattctaag     1260

atctgctttg gaaattattg cctctgatac atacctaagt aaacataaca ttaataccta     1320

agtaaacata acattacttg gagggttgca gtttctaagt gaaactgtat ttgaaacttt     1380

taagtatact ttaggaaaca agcatgaacg gcagtctaga ataccagaaa catctacttg     1440

ggtagcttgg tgccattatc ctgtggaatc tgatatgtct ggtagcatgt cattgatggg     1500

acatgaagac atctttggaa atgatgagat tatttcctgt gttaaaaaaa aaaaaaatct     1560

taaattccta caatgtgaaa ctgaaactaa taatttgatc ctgatgtatg ggacagcgta     1620

tctgtaccag tgctctaaat aacaaaagct agggtgacaa gtacatgttc cttttggaaa     1680

gaagcaaggc aatgtatatt aattattcta aaagggcttt gttcctttcc attttcttta     1740

acttctctga gatactgatt tgtaaatttt gaaaattagt taaaatatgc agttttttga     1800

gcccacgaat agttgtcatt tcctttatgt gcctgttagt aaaaagtagt attgtgtatt     1860

tgctcagtat ctgaactata agcccattta tactgttcca tacaaaagct atttttcaaa     1920

aattaatttg aaccaaaact actactatag ggaaaagatg ccaaaacatg tcccctcacc     1980

cagactaaac ttgatactgt attattttgt tcaatgtaaa ttgaagaaaa tctgtaagta     2040

agtaaacctt aagtgtgaaa ctaaacatgt tctttgttca aataatgtaa aatatctact     2100

cataatttta aagttctaaa aaggctgctt tgccacctac ctctttgctt atattcaagg     2160

gtttagtggg tccttccttc cacatttgta tgataacttt cgttttattg gtagtccttt     2220

gctactttaa aactaatcag gttaaatgtt tactcaaatg tagtaatagt atgaggccaa     2280

aatacatgcc ttgaaggtgg agtgaaatca gttgagtgtc acactgcata tttatgtaaa     2340

tagagtaaat gaaaattcaa gaatacttcc aatcaggata tgcccctgcc ttattttttc     2400

taaggtctac ttttactact ttaataattt tgggtttgtg tgacttcact ggtctggttt     2460

gttcctatag ttcttacact gcactaaaac ttacttactc caggaagttc ctgtcagtag     2520

catagtacct ctctgtaggc tgaactctaa accagttgca atgagttacc ttgtccctct     2580

gaaaagttaa aatttcagta tgtcccatac cgtttactag caaataaaat tttctgatct     2640

gtaaaaacac acatatacta tactactact gaaaatggtt ttacacatga caaaaccaga     2700

cctgatagct aaatctgcat actttctata cagaaatagt atgtattata tgacgttggg     2760

tctaaatctg tattttggca gtacttaaat attttaagta agtatttcaa agtattattt     2820

tataatgcat ctaattactg acctgtatgc agtcatttct gaggctttct tgcatcatag     2880

cccctgtgac atttcctctt agaaatatta cactctacaa aattgtttta tcaaggtcca     2940

aaattactat ttgctcatag agtacaaaga tgttatgact ggctacacag aaaggaaata     3000

aattatgaaa tgtcagtata gcagctgaaa ttatagcagc tgaaataaac agtttgtatt     3060

atacatttta tttacctgat gaaagcattt aggactcaaa tctttagaga atatataata     3120

atagccatat ccttttaatt aataaaataa cactttaaag acaggcatat taccattgta     3180

tatgacacct aatacacatt gtcagatacc acataaacat atttatcttc caataccaat     3240

gtttgtttta ttaaaacaat aattaattaa taggctcaat agtgaccctc aagttaatcc     3300

catgacttcc ccaggctctg catgcataaa gaaatcattg tgacagaaaa atatcaacca     3360

catactgaag catagcttgc tagaacaaat cctgtacata tgaatgccag caactgggga     3420

cacatttagt attcacattt tatgcaaact tacttggtca attatttctt ttttaagcac     3480

aggtttattt tggaattcag ataagaactg acacatcata gacagtcatt gttaaggtaa     3540

ccctgttatt tcaattgcaa acaaacaata aacgtttttt cttcaa                    3586


