                               SEQUENCE LISTING

<110> ARBOR BIOTECHNOLOGIES, INC.
 
<120> COMPOSITIONS COMPRISING A VARIANT POLYPEPTIDE AND USES THEREOF

<130> A2186-7045WO

<140>
<141>

<150> 63/176,021
<151> 2021-04-16

<150> 63/158,738
<151> 2021-03-09

<160> 66    

<170> PatentIn version 3.5

<210> 1
<211> 1792
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      parent sequence

<400> 1
attggtgata tcgcgagctt cctgaaagaa gcgaccaaca aggataccat cccgacctat       60

attaacatgg gcctgagcga ggaatggaag tacaaaccga tttatcacct gttcaccgac      120

gattaccacg agaagagcgc gaacaacctg ctgtacgcgt attttaagga gaaaaacctg      180

gactgctata acggtaacat cctgaacctg agcgaaacct actatcgtcg taacggttac      240

ttcaaaagcg tggttggcaa ctatcgtacc aagatccgta ccctgaacta caagattaag      300

cgtaagaacg tggacgagaa cagcaccaac gaggatatcg aactgcaggt tatgtatgaa      360

atcgcgaagc gtaagctgaa cattaagaaa gactgggaga actacatcag ctatattgag      420

aacgtggaaa acatcaacat caagaacatc gatcgttaca acctgctgta taagcacttc      480

tgcgagaacg aaagcaccat taactgcaag atggaactgc tgagcgtgga gcaactgaaa      540

gaatttggtg gctgcgttat gaagcagcac atcaacagca tgaccatcaa cattcaagat      600

ttcaaaatcg agaacaagga aaacagcctg ggttttattc tgaacctgcc gctgaacaag      660

aaaaagtacc agatcgagct gtggggtaac cgtcaaatta aaaagggcaa caaagataac      720

tacaagaccc tggtggattt catcaacacc tatggccaga acatcatctt caccatcaag      780

aacaacaaga tctacgtggt tttcagctat gagtgcgaac tgaaggagaa ggaaatcaac      840

ttcgacaaga tcgtgggtat tgatgttaac ttcaagcacg cgctgtttgt tgcgagcgag      900

cgtgacaaaa acccgctgca ggataacaac caactgaaag gctacatcaa cctgtacaag      960

tatctgctgg agcacaacga gttcaccagc ctgctgacca aagaggagct ggacatctac     1020

aaagaaattg cgaagggtgt gaccttctgc ccgctggagt ataacctgct gtttacccgt     1080

atcgaaaaca aaggtggcaa gagcaacgat aaagagcagg ttctgagcaa gctgctgtac     1140

agcctgcaaa ttaaactgaa gaacgagaac aaaatccagg aatacattta tgtgagctgc     1200

gttaacaaac tgcgtgcgaa gtacgtgagc tatttcatcc tgaaagagaa gtactatgaa     1260

aaacaaaagg agtacgacat tgaaatgggc tttaccgacg atagcaccga gagcaaagaa     1320

agcatggata agcgtcgtct ggagttcccg tttcgtaaca cccagatcgc gaacggtttc     1380

ctggagaagc tgagcaacgt tcagcaagac attaacggct gcctgaaaaa catcattaac     1440

tacgcgtata aggtgttcga acaaaacggt tttggcgtta tcgcgctgga gaacctggaa     1500

aacagcaact ttgagaaaac ccaagtgctg ccgaccatta aaagcctgct ggagtaccac     1560

aagctggaaa accagaacat caacaacatt aacgcgagcg acaaagttaa ggagtatatc     1620

gagaaggaat actatgaact gaccaccaac gagaacaacg aaattgtgga tgcgaaatac     1680

accaaaaagg gtatcattaa ggttaaaaag gcgaacttct ttaacctgat gatgaaaagc     1740

ctgcacttcg cgagcaacaa ggacgaattt atcctgctga gcaacaacgg ca             1792


<210> 2
<211> 2268
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      parent sequence

<400> 2
atgaccacaa agcaggtgaa gagcatcgtg ctgaaggtga agaacaccaa tgagtgccca       60

atcacaaagg acgtgatcaa cgagtacaag aagtactata atatctgttc cgagtggatc      120

aaggacaacc tgacctccat cacaatcggc gatatcgcct ctttcctgaa ggaggccacc      180

aataaggata ccatccccac atatatcaac atgggcctgt ccgaggagtg gaagtacaag      240

cctatctatc acctgttcac agacgattac cacgagaagt ctgccaacaa tctgctgtac      300

gcctacttca aggagaagaa cctggactgc tataacggca atatcctgaa tctgtccgag      360

acctactatc ggagaaacgg ctacttcaag tctgtggtgg gcaattatcg gaccaagatc      420

agaacactga actacaagat caagaggaag aatgtggacg agaactctac aaatgaggat      480

atcgagctgc aggtcatgta tgagatcgcc aagcgcaagc tgaacatcaa gaaggactgg      540

gagaattaca tcagctatat cgagaacgtg gagaacatca atatcaagaa catcgatagg      600

tacaatctgc tgtataagca cttctgcgag aacgagagca ccatcaattg taagatggag      660

ctgctgtccg tggagcagct gaaggagttt ggcggctgcg tgatgaagca gcacatcaac      720

tctatgacaa tcaatatcca ggatttcaag atcgagaaca aggagaatag cctgggcttt      780

atcctgaacc tgcccctgaa caagaagaag taccagatcg agctgtgggg caaccggcag      840

atcaagaagg gcaacaagga caattacaag accctggtgg atttcatcaa cacatatggc      900

cagaacatca tctttaccat caagaacaat aagatctacg tggtgttctc ctatgagtgt      960

gagctgaagg agaaggagat caactttgac aagatcgtgg gcatcgatgt gaatttcaag     1020

cacgccctgt ttgtggcctc tgagagagac aagaacccac tgcaggataa caatcagctg     1080

aagggctaca tcaacctgta caagtatctg ctggagcaca atgagttcac cagcctgctg     1140

acaaaggagg agctggacat ctacaaggag atcgccaagg gcgtgacctt ctgccccctg     1200

gagtataacc tgctgtttac aaggatcgag aacaagggcg gcaagtccaa tgataaggag     1260

caggtgctga gcaagctgct gtactccctg cagatcaagc tgaagaacga gaataagatc     1320

caggagtaca tctacgtgag ctgcgtgaat aagctgcgcg ccaagtacgt gagctatttc     1380

atcctgaagg agaagtacta tgagaagcag aaggagtacg acatcgagat gggctttacc     1440

gacgatagca cagagtccaa ggagtctatg gataagaggc gcctggagtt cccttttcgg     1500

aacacccaga tcgccaatgg cttcctggag aagctgagca acgtgcagca ggacatcaat     1560

ggctgtctga agaacatcat caattacgcc tataaggtgt tcgagcagaa cggctttggc     1620

gtgatcgccc tggagaatct ggagaacagc aattttgaga agacccaggt gctgccaaca     1680

atcaagtccc tgctggagta ccacaagctg gagaaccaga atatcaacaa tatcaacgcc     1740

tctgacaagg tgaaggagta tatcgagaag gagtactatg agctgaccac aaatgagaac     1800

aatgagatcg tggatgccaa gtacaccaag aagggcatca tcaaggtgaa gaaggccaac     1860

ttctttaatc tgatgatgaa gtctctgcac ttcgccagca acaaggacga gtttatcctg     1920

ctgtccaaca atggcaagac ccagatcgcc ctggtgccca gcgagtacac atcccagatg     1980

gattctatcg agcactgcct gtatgtggac aagaacggca agaaggtgga taagaagaag     2040

gtgcggcaga agcaggagac ccacatcaac ggcctgaatg ccgacttcaa tgccgccaac     2100

aatatcaagt acatcatcga gaacgagaat ctgagaaagc tgttttgtgg caagctgaag     2160

gtgtccggct ataacacccc tatcctggat gccacaaaga agggccagtt caacatcctg     2220

gccgagctga agaagcagaa taagatcaag atctttgaga tcgagaag                  2268


<210> 3
<211> 756
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      parent sequence

<400> 3
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Asp Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 4
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
ccuguuguga auacucuuuu auagguauca aacaac                                 36


<210> 5
<211> 35
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
ccuguuguga auacucuuua uagguaucaa acaac                                  35


<210> 6
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
ccuguuguga auacuc                                                       16


<210> 7
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
uuauagguau caaacaac                                                     18


<210> 8
<211> 61
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
ccuguuguga auacucuuuu auagguauca aacaacagcc aguguugcua gucaagggca       60

g                                                                       61


<210> 9
<211> 25
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      EMX1 mammalian target sequence

<400> 9
agccagtgtt gctagtcaag ggcag                                             25


<210> 10
<211> 61
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
ccuguuguga auacucuuuu auagguauca aacaacgaaa ucuauugagg cucuggagag       60

a                                                                       61


<210> 11
<211> 25
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      VEGFA mammalian target sequence

<400> 11
gaaatctatt gaggctctgg agaga                                             25


<210> 12
<211> 61
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
ccuguuguga auacucuuuu auagguauca aacaacuagc cucucccgcu cugguucagg       60

g                                                                       61


<210> 13
<211> 25
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      AAVS1 mammalian target sequence

<400> 13
tagcctctcc cgctctggtt caggg                                             25


<210> 14
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Asp Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 15
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Asp Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 16
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Asp Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 17
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Asp Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 18
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 19
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Asp Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 20
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 21
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Asp Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 22
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 23
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Asp Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 24
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 25
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 26
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Asp Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 27
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Asp Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 28
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 29
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Asp Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 30
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 31
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 32
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Asp Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 33
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 34
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 35
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 36
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Asp Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 37
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Glu Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 38
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 39
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 40
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Asp Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 41
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 42
<211> 56
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
ccuguuguga auacucuuuu auagguauca aacaacugag aauggugcgu ccuagg           56


<210> 43
<211> 20
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      AAVS1 mammalian target sequence

<400> 43
tgagaatggt gcgtcctagg                                                   20


<210> 44
<211> 56
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
ccuguuguga auacucuuuu auagguauca aacaacucca gaccaccaau gggcac           56


<210> 45
<211> 20
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      VEGFA mammalian target sequence

<400> 45
tccagaccac caatgggcac                                                   20


<210> 46
<211> 56
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
ccuguuguga auacucuuuu auagguauca aacaacccgc cgcuuccuga gccauc           56


<210> 47
<211> 20
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      EMX1 mammalian target sequence

<400> 47
ccgccgcttc ctgagccatc                                                   20


<210> 48

<400> 48
000


<210> 49
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Arg Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Gly Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 50
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Arg Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Gly Leu Gln Gly Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 51
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Arg Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Leu Gln Gly Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Arg Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 52
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Arg Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Gly Leu Gln Gly Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Gly 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Arg Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 53
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Arg Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 54
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Thr Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Gly Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 55
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Arg Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Gly Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 56
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Arg Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Gly Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Glu Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 57
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Arg Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Pro Gly Gln Asp Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Arg Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 58
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Met Thr Thr Lys Gln Val Lys Ser Ile Val Leu Lys Val Lys Asn Thr 
1               5                   10                  15      


Asn Glu Cys Pro Ile Thr Lys Asp Val Ile Asn Glu Tyr Lys Lys Tyr 
            20                  25                  30          


Tyr Asn Ile Cys Ser Glu Trp Ile Lys Asp Asn Leu Thr Ser Ile Thr 
        35                  40                  45              


Ile Gly Asp Ile Ala Ser Phe Leu Lys Glu Ala Arg Asn Lys Asp Thr 
    50                  55                  60                  


Ile Pro Thr Tyr Ile Asn Met Gly Leu Ser Glu Glu Trp Lys Tyr Lys 
65                  70                  75                  80  


Pro Ile Tyr His Leu Phe Thr Asp Arg Tyr His Glu Lys Ser Ala Asn 
                85                  90                  95      


Asn Leu Leu Tyr Ala Tyr Phe Lys Glu Lys Asn Leu Asp Cys Tyr Asn 
            100                 105                 110         


Gly Asn Ile Leu Asn Leu Ser Glu Thr Tyr Tyr Arg Arg Asn Gly Tyr 
        115                 120                 125             


Phe Lys Ser Val Val Gly Asn Tyr Arg Thr Lys Ile Arg Thr Leu Asn 
    130                 135                 140                 


Tyr Lys Ile Lys Arg Lys Asn Val Asp Glu Asn Ser Thr Asn Glu Asp 
145                 150                 155                 160 


Ile Glu Leu Gln Val Met Tyr Glu Ile Ala Lys Arg Lys Leu Asn Ile 
                165                 170                 175     


Lys Lys Asp Trp Glu Asn Tyr Ile Ser Tyr Ile Glu Asn Val Glu Asn 
            180                 185                 190         


Ile Asn Ile Lys Asn Ile Asp Arg Tyr Asn Leu Leu Tyr Lys His Phe 
        195                 200                 205             


Cys Glu Asn Glu Ser Thr Ile Asn Cys Lys Met Glu Leu Leu Ser Val 
    210                 215                 220                 


Glu Gln Leu Lys Glu Phe Gly Gly Cys Val Met Lys Gln His Ile Asn 
225                 230                 235                 240 


Ser Met Thr Ile Asn Ile Gln Asp Phe Lys Ile Glu Asn Lys Glu Asn 
                245                 250                 255     


Ser Leu Gly Phe Ile Leu Asn Leu Pro Leu Asn Lys Lys Lys Tyr Gln 
            260                 265                 270         


Ile Glu Leu Trp Gly Asn Arg Gln Ile Lys Lys Gly Asn Lys Asp Asn 
        275                 280                 285             


Tyr Lys Thr Leu Val Asp Phe Ile Asn Thr Tyr Gly Gln Asn Ile Ile 
    290                 295                 300                 


Phe Thr Ile Lys Asn Asn Lys Ile Tyr Val Val Phe Ser Tyr Glu Cys 
305                 310                 315                 320 


Glu Leu Lys Glu Lys Glu Ile Asn Phe Asp Lys Ile Val Gly Ile Asp 
                325                 330                 335     


Val Asn Phe Lys His Ala Leu Phe Val Ala Ser Glu Arg Asp Lys Asn 
            340                 345                 350         


Gly Gly Gln Gly Asn Asn Gln Leu Lys Gly Tyr Ile Asn Leu Tyr Lys 
        355                 360                 365             


Tyr Leu Leu Glu His Asn Glu Phe Thr Ser Leu Leu Thr Lys Glu Glu 
    370                 375                 380                 


Leu Asp Ile Tyr Lys Glu Ile Ala Lys Gly Val Thr Phe Cys Pro Leu 
385                 390                 395                 400 


Glu Tyr Asn Leu Leu Phe Thr Arg Ile Glu Asn Lys Gly Gly Lys Ser 
                405                 410                 415     


Asn Asp Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ser Leu Gln Ile 
            420                 425                 430         


Lys Leu Lys Asn Glu Asn Lys Ile Gln Glu Tyr Ile Tyr Val Ser Cys 
        435                 440                 445             


Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys Glu 
    450                 455                 460                 


Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe Thr 
465                 470                 475                 480 


Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Leu Glu 
                485                 490                 495     


Phe Pro Phe Arg Asn Thr Gln Ile Ala Asn Gly Phe Leu Glu Lys Leu 
            500                 505                 510         


Ser Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile Asn 
        515                 520                 525             


Tyr Ala Tyr Lys Val Phe Glu Gln Asn Gly Phe Gly Val Ile Ala Leu 
    530                 535                 540                 


Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Thr Gln Val Leu Pro Thr 
545                 550                 555                 560 


Ile Lys Ser Leu Leu Arg Tyr His Lys Leu Arg Asn Gln Asn Ile Asn 
                565                 570                 575     


Asn Ile Asn Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Lys Glu Tyr 
            580                 585                 590         


Tyr Glu Leu Thr Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys Tyr 
        595                 600                 605             


Thr Lys Lys Gly Ile Ile Lys Val Lys Lys Ala Asn Phe Phe Asn Leu 
    610                 615                 620                 


Met Met Lys Ser Leu His Phe Ala Ser Asn Lys Asp Glu Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu Tyr 
                645                 650                 655     


Thr Ser Gln Met Asp Ser Ile Glu His Cys Leu Tyr Val Asp Lys Asn 
            660                 665                 670         


Gly Lys Lys Val Asp Lys Lys Lys Val Arg Gln Lys Gln Glu Thr His 
        675                 680                 685             


Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala Asn Asn Ile Lys Tyr 
    690                 695                 700                 


Ile Ile Glu Asn Glu Asn Leu Arg Lys Leu Phe Cys Gly Lys Leu Lys 
705                 710                 715                 720 


Val Ser Gly Tyr Asn Thr Pro Ile Leu Arg Ala Thr Lys Lys Gly Gln 
                725                 730                 735     


Phe Asn Ile Leu Ala Glu Leu Lys Lys Gln Asn Lys Ile Lys Ile Phe 
            740                 745                 750         


Glu Ile Glu Lys 
        755     


<210> 59
<211> 2268
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 59
atgactacca agcaagtcaa atccatagta ctgaaggtta agaatacaaa tgaatgccca       60

atcaccaagg atgtgatcaa cgagtacaag aagtattata atatctgtag cgagtggatt      120

aaagataatc tgacctctat aaccatcggc gacatcgcct cttttttgaa agaagcaaca      180

aacaaagata ctatcccaac gtacatcaat atgggactta gtgaagagtg gaaatacaag      240

cctatctacc atctctttac cgacagatac cacgagaaat cagccaacaa cctgctttat      300

gcttacttta aggaaaagaa tctggattgt tataatggca atatcctcaa cttgtccgag      360

acatactacc gtcgcaatgg atacttcaag tcggtagtgg ggaactatcg tacaaaaatt      420

cgcacactta actataagat taagagaaaa aacgttgacg agaatagcac caatgaagat      480

attgaactcc aagttatgta tgaaatcgca aagcgcaagc tgaacattaa gaaggactgg      540

gagaattata tctcatacat tgagaatgtc gagaacatca acatcaaaaa tatcgatcgg      600

tacaacctgc tatacaagca tttctgtgaa aatgagtcca ccatcaactg caagatggag      660

ttgctctctg tggaacagct caaagagttc gggggttgtg tgatgaagca gcacataaat      720

tccatgacga taaacataca ggactttaag attgaaaaca aggagaactc actgggtttc      780

atcctgaacc tgcccttgaa caagaaaaag taccagatag aactgtgggg gaaccgacaa      840

atcaaaaaag ggaataagga taactataag acgctggttg actttatcaa cacttatggt      900

cagaacatta ttttcaccat taaaaataat aaaatttacg tcgtgttcag ctacgagtgt      960

gaattaaagg agaaggaaat caatttcgac aagattgtcg ggattgatgt gaatttcaag     1020

cacgccctgt ttgtggcttc cgagcgggac aaaaacccac tgcaagataa taaccagcta     1080

aaagggtaca taaacctgta tggctatctt ctggagcata atgaatttac aagcctgctg     1140

accaaggagg aactggacat ttataaagaa attgcgaagg gcgtcacatt ttgtcccctg     1200

gagtacaact tgcttttcac tagaatagag aataagggcg gaaagtctaa cgacaaagaa     1260

caggtgctga gcaagctgct ctatagcttg cagatcaaac tcaaaaatga aaataagatt     1320

caggagtata tctatgtgag ttgcgtaaat aagctccgag ccaaatacgt gtcatacttt     1380

atcttgaaag aaaaatacta cgaaaagcag aaagagtacg acatcgagat gggcttcacg     1440

gatgactcga ctgagtctaa agagtctatg gacaagaggc ggctggagtt cccctttagg     1500

aatactcaga ttgctaatgg cttcctcgaa aaactctcca acgtgcagca agatatcaac     1560

ggatgcttaa agaatattat taactatgcc tataaagtat tcgagcaaaa cggatttgga     1620

gtcatcgcac tggaaaactt agagaacagc aacttcgaaa agacacaggt cttacctaca     1680

atcaagagtc tacttcggta tcataagttg gagaatcaga atattaataa tattaacgcg     1740

agtgacaagg tgaaagagta catagagaag gagtattacg aactaactac caacgagaac     1800

aatgaaatag tcgatgctaa atacactaaa aagggaatta tcaaggtgaa aaaagctaac     1860

ttttttaacc taatgatgaa atccctgcac tttgccagta acaaagatga gttcatcttg     1920

ctgagcaata acggtaaaac acaaattgca ctggttccga gcgagtatac ctcccagatg     1980

gactctatag aacactgcct ctacgtggac aaaaatggga aaaaagtgga caaaaagaag     2040

gttaggcaga agcaggaaac tcacatcaac ggcctcaacg ccgatttcaa cgccgctaac     2100

aatataaagt acatcatcga aaacgagaat cttaggaagc tgttttgcgg caagctgaag     2160

gtgtcaggtt ataacacccc tatcctcaga gccaccaaaa agggccagtt caatattctg     2220

gcagagctga agaagcagaa taagattaaa atcttcgaga ttgagaaa                  2268


<210> 60
<211> 2268
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 60
atgaccacca agcaagtgaa gagcatcgtg ctgaaggtga agaacaccaa cgagtgcccc       60

atcaccaagg acgtgatcaa cgagtacaag aagtactaca acatctgcag cgagtggatc      120

aaggacaacc tgacaagcat caccatcggc gacatcgcta gcttcctgaa ggaggccacc      180

aacaaggaca ccatccccac ctacatcaac atgggcctga gcgaggagtg gaagtacaag      240

cccatctacc acctgttcac cgacagatac cacgagaaga gcgccaataa cctgctgtac      300

gcctatttca aggagaagaa cctggactgc tacaacggca acatcctgaa cctgagcgag      360

acctactaca gaagaaacgg ctacttcaag agcgtggtgg gcaactacag aaccaagatc      420

agaaccctga actataagat caagcgtaaa aacgtggacg agaacagcac caacgaggac      480

atcgagctgc aagtgatgta cgagatcgcc aaaagaaagc tgaacatcaa gaaggactgg      540

gagaactaca tcagctacat cgagaacgtg gaaaacatca atattaagaa catcgacaga      600

tataaccttt tgtacaagca tttctgcgag aacgagagca ccatcaactg caagatggag      660

ctgctgagcg tggagcagct gaaggagttc ggcggctgcg tgatgaagca gcacatcaac      720

agcatgacca tcaacatcca agacttcaag atcgaaaaca aagaaaacag cctgggcttt      780

atcctcaacc ttccactgaa caagaagaag tatcagatcg agctgtgggg caacagacag      840

atcaagaagg gcaacaagga caactataag acgttagtgg acttcatcaa cacctacggg      900

cagaacatca tcttcaccat caagaacaac aagatctacg tggtgttcag ctacgagtgc      960

gagctgaaag agaaggaaat caacttcgac aagatcgtgg gcatcgacgt gaacttcaag     1020

cacgccctgt tcgtggctag cgagagagac aagaaccccc tgcaagacaa caatcagctg     1080

aagggctaca tcaacctgta cggctacctg ctggagcaca acgagttcac aagcctgctg     1140

accaaggagg agctggacat ctacaaggag atcgccaagg gtgtcacctt ctgccccctg     1200

gagtacaacc ttcttttcac aagaatcgag aacaagggcg gcaagagcaa cgacaaggag     1260

caagtgctga gcaagctgct gtacagcctg cagatcaagc tgaagaacga gaacaagatc     1320

caagagtaca tctacgtgag ctgcgtgaac aagctgagag ccaagtacgt gagctacttc     1380

atcctgaagg aaaagtacta cgagaagcag aaggagtacg acatcgagat gggcttcacc     1440

gacgacagca ccgagagcaa ggagagcatg gacaagagaa gactggagtt ccccttcaga     1500

aacacacaga tcgccaacgg gttcctggag aagctgagca acgtgcagca agacatcaac     1560

ggctgcctga agaacatcat caactacgcc tacaaggtgt tcgagcagaa cggcttcggc     1620

gtgatcgccc tggagaacct ggagaacagc aacttcgaga agacccaagt gctgcccacc     1680

atcaagagcc tgctgagata ccacaagctg gagaaccaaa atatcaataa tatcaatgct     1740

agcgacaagg tgaaggagta catcgagaag gagtactacg agctgaccac caacgagaac     1800

aacgagatcg tggacgccaa gtacactaag aagggtataa tcaaggtgaa gaaggccaac     1860

ttcttcaacc tgatgatgaa gagcctgcac ttcgctagca acaaggacga gttcatcctg     1920

ctgagcaaca acggcaagac acagatcgca ctggtgccta gcgagtacac atctcagatg     1980

gacagcatcg agcactgcct gtacgtggac aagaacggca agaaggtgga caagaagaag     2040

gtgagacaga agcaagagac ccacatcaac ggcctgaacg ccgacttcaa cgccgccaac     2100

aacatcaagt atatcatcga gaacgagaac ctgagaaagc tgttctgcgg caagctgaag     2160

gtgagcggct acaacacccc catcctgaga gccacaaaga aagggcagtt taacatcctg     2220

gccgagctga agaagcagaa caagatcaag atctttgaga tcgagaag                  2268


<210> 61
<211> 2268
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 61
atgaccacca agcaggtgaa gagcatcgtg ctgaaggtga agaacaccaa cgagtgcccc       60

atcaccaagg acgtgatcaa cgagtacaag aagtactaca acatctgcag cgagtggatc      120

aaggacaacc tgaccagcat caccatcggc gacatcgcca gcttcctgaa ggaggccacc      180

aacaaggaca ccatccccac ctacatcaac atgggcctga gcgaggagtg gaagtacaag      240

cccatctacc acctgttcac cgaccggtac cacgagaaga gcgccaacaa cctgctgtac      300

gcctacttca aggagaagaa cctggactgc tacaacggca acatcctgaa cctgagcgag      360

acctactacc ggcggaacgg ctacttcaag agcgtggtgg gcaactaccg gaccaagatc      420

cggaccctga actacaagat caagcggaag aacgtggacg agaacagcac caacgaggac      480

atcgagctgc aggtgatgta cgagatcgcc aagcggaagc tgaacatcaa gaaggactgg      540

gagaactaca tcagctacat cgagaacgtg gagaacatca acatcaagaa catcgaccgg      600

tacaacctgc tgtacaagca cttctgcgag aacgagagca ccatcaactg caagatggag      660

ctgctgagcg tggagcagct gaaggagttc ggcggctgcg tgatgaagca gcacatcaac      720

agcatgacca tcaacatcca ggacttcaag atcgagaaca aggagaacag cctgggcttc      780

atcctgaacc tgcccctgaa caagaagaag taccagatcg agctgtgggg caaccggcag      840

atcaagaagg gcaacaagga caactacaag accctggtgg acttcatcaa cacctacggc      900

cagaacatca tcttcaccat caagaacaac aagatctacg tggtgttcag ctacgagtgc      960

gagctgaagg agaaggagat caacttcgac aagatcgtgg gcatcgacgt gaacttcaag     1020

cacgccctgt tcgtggccag cgagcgggac aagaaccccc tgcaggacaa caaccagctg     1080

aagggctaca tcaacctgta cggctacctg ctggagcaca acgagttcac cagcctgctg     1140

accaaggagg agctggacat ctacaaggag atcgccaagg gcgtgacctt ctgccccctg     1200

gagtacaacc tgctgttcac ccggatcgag aacaagggcg gcaagagcaa cgacaaggag     1260

caggtgctga gcaagctgct gtacagcctg cagatcaagc tgaagaacga gaacaagatc     1320

caggagtaca tctacgtgag ctgcgtgaac aagctgcggg ccaagtacgt gagctacttc     1380

atcctgaagg agaagtacta cgagaagcag aaggagtacg acatcgagat gggcttcacc     1440

gacgacagca ccgagagcaa ggagagcatg gacaagcggc ggctggagtt ccccttccgg     1500

aacacccaga tcgccaacgg cttcctggag aagctgagca acgtgcagca ggacatcaac     1560

ggctgcctga agaacatcat caactacgcc tacaaggtgt tcgagcagaa cggcttcggc     1620

gtgatcgccc tggagaacct ggagaacagc aacttcgaga agacccaggt gctgcccacc     1680

atcaagagcc tgctgcggta ccacaagctg gagaaccaga acatcaacaa catcaacgcc     1740

agcgacaagg tgaaggagta catcgagaag gagtactacg agctgaccac caacgagaac     1800

aacgagatcg tggacgccaa gtacaccaag aagggcatca tcaaggtgaa gaaggccaac     1860

ttcttcaacc tgatgatgaa gagcctgcac ttcgccagca acaaggacga gttcatcctg     1920

ctgagcaaca acggcaagac ccagatcgcc ctggtgccca gcgagtacac cagccagatg     1980

gacagcatcg agcactgcct gtacgtggac aagaacggca agaaggtgga caagaagaag     2040

gtgcggcaga agcaggagac ccacatcaac ggcctgaacg ccgacttcaa cgccgccaac     2100

aacatcaagt acatcatcga gaacgagaac ctgcggaagc tgttctgcgg caagctgaag     2160

gtgagcggct acaacacccc catcctgcgg gccaccaaga agggccagtt caacatcctg     2220

gccgagctga agaagcagaa caagatcaag atcttcgaga tcgagaag                  2268


<210> 62
<211> 2268
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 62
atgactacga aacaagtaaa gtctattgtg cttaaagtga agaatactaa cgagtgtccc       60

attaccaagg atgttataaa tgaatacaaa aaatattata acatctgcag cgaatggata      120

aaagataacc ttacttctat tactataggg gatatagcgt cctttctgaa ggaggcgacg      180

aacaaagaca ctatcccgac ctacatcaac atggggctct ccgaagaatg gaagtacaag      240

cctatctacc atcttttcac cgacagatat catgagaaat ccgcaaataa tttgttgtat      300

gcttacttca aagagaagaa cttggattgc tacaacggta atattcttaa tctctcagag      360

acttattaca ggaggaacgg gtactttaaa agcgtggtcg gaaattatcg cacaaaaata      420

cgcacattga attataaaat caagcgaaaa aacgtcgatg aaaactctac aaacgaggat      480

attgagctgc aagtgatgta tgaaatcgca aagagaaaac tgaacatcaa gaaggattgg      540

gagaattaca tatcctatat cgaaaacgtg gagaatatca acatcaagaa catagataga      600

tataatctgc tctataagca tttttgcgaa aacgagtcta caattaactg caagatggag      660

ctgctttccg tagagcaact taaggaattt ggtggatgcg ttatgaagca gcatatcaac      720

agtatgacta ttaatataca ggattttaag atcgagaata aggaaaactc cctgggcttt      780

attctcaatc tgcccctgaa caaaaaaaag tatcagatag aactctgggg caatagacag      840

attaagaaag gtaataagga caattataaa accctcgtag actttataaa tacatacggg      900

caaaacatca ttttcacgat taagaataac aaaatttatg ttgtgttctc ctatgagtgt      960

gaactgaagg agaaagagat taacttcgat aagatagttg ggattgatgt gaactttaaa     1020

cacgcccttt tcgttgcgtc cgagagggac aagaatccct tgcaggataa taatcaactg     1080

aagggttaca tcaatctcta tggatacttg ctggaacaca acgaattcac aagtctcctg     1140

acgaaggagg aactcgatat ttataaggaa atagccaaag gagttacctt ttgtccgctc     1200

gagtataatc ttctcttcac acggatcgaa aacaaaggag gaaagagcaa tgataaagaa     1260

caagtacttt ccaaacttct ttatagtctc caaattaagc tgaagaacga gaacaagatc     1320

caggagtata tatatgtgtc atgtgtgaat aagctgcgag cgaaatacgt atcttacttc     1380

attctcaaag aaaaatatta tgagaagcag aaagaatacg atattgaaat gggctttaca     1440

gacgactcaa ccgagtccaa agagtctatg gacaaaagac gattggagtt cccgtttcga     1500

aatacacaga tcgccaatgg tttcctcgag aagctgagta atgtgcagca agatataaat     1560

ggctgcctta agaatataat taactacgct tacaaggtgt ttgaacaaaa tgggttcggc     1620

gttatcgccc tcgaaaacct tgaaaattct aactttgaaa agacgcaagt ccttcctaca     1680

attaagtccc ttcttcgcta tcacaaactg gagaaccaaa atatcaataa cattaatgct     1740

tcagataaag ttaaggaata catagaaaag gagtactacg aacttaccac caacgaaaac     1800

aatgaaattg tagacgctaa gtacacaaag aagggcatta taaaagttaa aaaagcgaac     1860

ttctttaact tgatgatgaa atcacttcat tttgcgtcaa acaaagacga gtttatcttg     1920

ctcagcaata atggtaagac tcaaatcgcc ctcgtccctt ctgagtatac aagccagatg     1980

gattctattg agcactgtct ctacgtggat aagaacggaa agaaagtaga caagaaaaag     2040

gtcaggcaga aacaagagac acacatcaat gggctgaatg ccgactttaa tgccgcaaac     2100

aacataaagt atataatcga gaacgaaaac ctccgaaagc tgttttgcgg taaactgaaa     2160

gtgagcgggt acaatacacc tatcctgcgc gctaccaaaa aaggccaatt taatatactg     2220

gctgagctca agaagcaaaa taaaatcaaa atctttgaga tagagaag                  2268


<210> 63
<211> 2268
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 63
atgaccacca agcaagtgaa atctatcgtg ctgaaggtga agaacaccaa cgaatgccct       60

atcaccaagg atgtgatcaa cgagtacaag aagtattata acatctgcag cgagtggatc      120

aaagataatt tgacaagcat caccatcggc gacatcgcct ccttcctgaa ggaagccacc      180

aacaaggata caatacccac ctacatcaac atgggcctga gcgaggaatg gaaatacaag      240

cccatctacc atctgtttac cgaccgctac cacgagaaaa gcgccaacaa cctgctctac      300

gcttatttca aggagaagaa cctggactgc tacaatggaa atatcctgaa cctgtctgag      360

acatactaca gaagaaacgg ctatttcaag agtgtggtcg gaaactacag gaccaaaatc      420

cggaccctga actacaagat caagcggaag aacgtggacg agaattctac caacgaggac      480

atcgagctgc aggtgatgta cgagatcgct aagcggaagc tgaatatcaa gaaagactgg      540

gagaactaca tcagctacat cgagaacgtg gaaaacatca acatcaagaa tatcgataga      600

tacaatctgc tgtacaagca cttctgcgag aacgagagca ccatcaactg caagatggaa      660

ctcctgagcg tggaacagct gaaagagttc ggcggctgtg tgatgaaaca acacatcaat      720

agcatgacca tcaacattca ggacttcaag atcgagaaca aggaaaatag cttgggcttc      780

atcctgaacc tgcctctgaa caagaagaag taccagatcg agctctgggg caacagacag      840

atcaagaaag gcaataagga taactacaaa accctggtcg atttcatcaa cacatacggg      900

cagaacataa tctttacaat caagaacaac aaaatctacg tggtgttcag ctacgaatgt      960

gaactgaagg aaaaagaaat caacttcgac aagattgtgg gcatcgacgt gaactttaag     1020

cacgccctgt tcgtggcctc tgaaagagat aagaatcctc tgcaagacaa caatcaactg     1080

aagggctaca tcaacctcta cggctacctg ctggagcaca acgagttcac atctctgctg     1140

accaaggaag aactggatat ctataaggag attgccaagg gtgttacatt ctgcccactg     1200

gaatacaacc tgctgttcac cagaatcgag aacaagggcg gaaagtccaa cgacaaggag     1260

caggtgctgt ctaagctgct gtacagcctg cagatcaagc tgaagaatga aaacaagatc     1320

caggagtaca tctacgtgag ctgcgtgaac aagctgcggg ccaaatacgt gtcctacttc     1380

atcctgaagg aaaaatacta cgagaagcag aaggaatacg acatcgagat gggatttaca     1440

gacgacagca ccgagagcaa ggaaagcatg gacaaacgga gactggaatt ccccttcaga     1500

aacacccaga tcgccaacgg cttcctggaa aagctgagca acgtgcagca ggacatcaac     1560

ggctgtctga aaaacatcat taactacgcc tacaaagtct tcgagcagaa cggctttggc     1620

gtgatagctc tggaaaacct ggaaaacagc aacttcgaga agacccaggt gctgcctacc     1680

atcaagagcc tgctgcggta ccacaagctc gagaaccaga atattaacaa cattaatgcc     1740

agcgacaagg tgaaggagta tattgagaag gaatactacg agctgacaac caacgagaac     1800

aacgaaatcg tggacgccaa gtacaccaag aagggcatca tcaaggtgaa gaaggccaat     1860

tttttcaacc tgatgatgaa gtctctgcac ttcgcctcta ataaagatga gttcatcctg     1920

ctgtccaaca atggcaaaac ccagatcgct ctggtgccta gcgagtatac tagccagatg     1980

gatagcatcg agcactgtct gtacgtggac aagaacggca agaaggtgga caagaagaaa     2040

gttagacaga aacaggagac ccacatcaac ggacttaacg ccgactttaa cgccgctaac     2100

aacataaagt acatcatcga gaatgagaac cttagaaagc tgttttgcgg caagctgaaa     2160

gtctccggct acaacacccc tatcctgaga gccacaaaga aaggacagtt caacatcctg     2220

gccgagctga agaaacagaa caagatcaag atcttcgaga tcgagaag                  2268


<210> 64
<211> 2268
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 64
atgaccacta agcaagtgaa atccatcgtc ttgaaagtaa agaataccaa tgagtgccct       60

attacaaagg acgttatcaa tgagtataaa aaatactaca acatctgttc tgaatggatt      120

aaagacaacc tcacgagcat cactatagga gatatcgcat ccttcctgaa ggaggcaacc      180

aacaaggata ccatccctac atatataaac atggggcttt cagaggagtg gaaatacaag      240

cccatttatc accttttcac agatagatac cacgaaaaaa gtgcaaataa cttgctttac      300

gcttacttta aagagaaaaa cttggactgt tacaatggta acattctgaa cctgtccgag      360

acatactaca gacggaacgg ctacttcaaa tcagtcgtcg ggaattatag gaccaagatc      420

cggaccttga actacaaaat taaaagaaaa aatgttgatg agaatagcac aaacgaagac      480

attgagctgc aagtaatgta tgagattgca aagagaaagc tgaacatcaa aaaggattgg      540

gagaattaca tatcctacat tgagaatgtg gaaaatatca acattaagaa tatagaccgc      600

tacaacctgc tgtataaaca cttctgcgag aatgaaagca ctataaattg caagatggag      660

ctgctgtcag tggagcagtt gaaagaattt ggagggtgtg tgatgaagca acatatcaat      720

agtatgacaa ttaacataca ggacttcaag attgaaaaca aggagaattc cctgggattc      780

atcctcaatc tgccattgaa taaaaagaaa taccaaatag aattgtgggg aaaccgacag      840

atcaagaagg gaaataagga caactataag accctggtcg actttatcaa cacatatggc      900

cagaacatta ttttcactat aaaaaacaac aagatctacg tggtattcag ctacgagtgc      960

gagctgaaag agaaagaaat taattttgac aaaattgtag gaatcgatgt gaacttcaaa     1020

cacgccctgt tcgtcgccag cgaaagagac aagaatccgc tgcaggataa caatcagctg     1080

aagggctaca tcaatctcta tggttatctc ctggagcaca atgaattcac aagtctgctg     1140

accaaagagg aattggatat ctacaaggaa atcgccaagg gggtcacctt ttgtccactg     1200

gagtacaacc tgctgttcac gcgcatcgag aataaaggcg ggaaaagtaa tgataaagaa     1260

caagtactga gtaagctgtt gtatagcctg cagattaagc tcaagaatga aaacaagatc     1320

caggagtaca tttacgtgag ctgcgtcaat aagctgaggg ctaagtacgt gtcatatttt     1380

attctcaaag aaaagtatta tgagaaacag aaagagtacg acatcgagat gggatttaca     1440

gacgattcta ccgaaagcaa ggaatcaatg gacaagcgcc gcttggagtt tcctttcaga     1500

aacactcaga tcgccaatgg attcctggaa aagctgagta acgtgcaaca ggacatcaat     1560

ggttgtctca agaacattat taactacgca tacaaggtgt ttgaacagaa cgggttcggt     1620

gtgattgctc ttgaaaacct ggaaaatagc aacttcgaaa agacacaggt cctcccaaca     1680

attaaatcac tgctcagata tcacaagctc gaaaaccaga acatcaataa tatcaacgcc     1740

tccgataaag tgaaagagta cattgaaaag gagtactacg agctgacaac caacgaaaac     1800

aatgaaattg tggatgctaa gtacaccaaa aagggaatta tcaaggtgaa gaaagctaat     1860

tttttcaacc tgatgatgaa gagcctgcat ttcgcttcca ataaggatga atttattctt     1920

ctgtcaaaca atggaaagac ccagatcgcc ctcgtgccaa gtgagtatac atcacagatg     1980

gactctattg agcattgtct ctatgtggat aagaacggaa agaaggtcga taagaagaaa     2040

gtgcgacaga aacaagagac gcatatcaat ggcctcaatg ctgattttaa tgccgcaaac     2100

aatataaaat atatcattga aaacgagaat ttgcgcaagc tgttttgcgg gaagctgaaa     2160

gtttctgggt ataatacccc tatcttgcgc gccactaaga agggacaatt taatatcctg     2220

gctgagctga agaaacaaaa taaaatcaaa atattcgaga tcgagaag                  2268


<210> 65
<211> 2268
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 65
atgaccacca agcaggtgaa atcaattgtg ctgaaggtga agaataccaa tgagtgcccc       60

atcacaaagg acgtgatcaa cgagtacaag aagtactata atatctgtag cgagtggatc      120

aaggacaatc tgacatccat cactatcggc gacatcgcct ccttcctgaa ggaggccacc      180

aacaaggaca caatccctac ttacatcaac atgggactgt ccgaggaatg gaagtacaag      240

ccaatctacc acctgtttac cgataggtac cacgagaaat ccgccaataa cctgctgtac      300

gcatatttca aggaaaagaa tctggactgc tataacggga atatcctgaa cctgtccgag      360

acgtactacc ggcgcaacgg atacttcaag agcgtggtgg gcaactaccg caccaagatc      420

agaaccctga attacaagat taagagaaaa aacgtggacg aaaatagcac caacgaggat      480

atcgagctgc aggtgatgta cgagatcgcc aaacggaaac tgaatatcaa gaaagattgg      540

gagaactata tcagttatat tgagaatgtg gagaatatca acatcaaaaa cattgacaga      600

tacaacctgc tctacaaaca cttttgtgaa aacgagtcta ccatcaattg taagatggag      660

ctgctgtccg tggaacagct gaaggagttt ggcggctgtg tgatgaagca gcatatcaac      720

tccatgacca tcaatatcca ggacttcaag atcgagaata aggagaatag cctggggttt      780

atcctgaacc tgcctctgaa caagaagaag tatcagatcg agctgtgggg aaaccgccag      840

atcaagaagg gcaacaaaga taactataag accctggtgg acttcatcaa cacatacggg      900

cagaatatca tcttcaccat taagaacaac aagatctatg tggtgtttag ttacgagtgc      960

gagctgaagg agaaggagat taatttcgac aagatcgtgg gaattgacgt gaatttcaag     1020

cacgctctgt tcgtggcttc agagagagac aagaatccac tgcaggacaa caaccagctg     1080

aagggttaca ttaaccttta cggctacctg ctggagcaca atgagtttac cagcctgctg     1140

actaaggagg agctggacat atacaaggaa atcgccaagg gcgtgacgtt ctgcccactg     1200

gagtataacc tgctctttac acggatcgag aataaaggcg ggaaaagcaa tgacaaggag     1260

caggtgctgt ctaaactgct gtattcactg cagatcaagc tgaaaaacga gaacaagatc     1320

caggaataca tttacgtgag ctgcgtgaac aaactgaggg ccaagtatgt gtcatatttc     1380

atcctgaagg agaagtacta tgagaagcag aaggagtacg acatcgagat gggatttact     1440

gacgactcca ccgagagcaa ggagagcatg gataagagaa gactggagtt cccattccgc     1500

aacacccaga tcgccaacgg ctttctggaa aaactgagta acgtgcagca ggacattaat     1560

ggatgtctga agaatatcat caactacgct tacaaggtgt ttgagcagaa cggatttggc     1620

gttatcgccc tggaaaacct ggaaaactcc aactttgaga agacacaggt gctgccaacc     1680

atcaagagcc tgctgaggta ccacaagctg gagaatcaga acattaacaa tatcaacgct     1740

agcgacaaag tgaaggagta cattgagaaa gaatactacg agctgaccac caatgaaaac     1800

aacgagatcg tggacgccaa gtataccaag aaaggcatca tcaaggtcaa aaaggctaat     1860

ttcttcaatc tgatgatgaa aagcctgcac tttgcctcca ataaagacga gtttattctc     1920

ctgagtaata acggcaagac ccagatcgcc ctggtgccat cagagtatac cagccagatg     1980

gattcaattg agcactgtct gtacgtggac aagaatggca agaaagtgga caagaagaaa     2040

gttcgacaga agcaggaaac ccacatcaat ggactcaatg cagatttcaa tgccgccaac     2100

aatatcaagt acattatcga gaacgagaac ctccggaagc tgttttgcgg caagctgaag     2160

gtgtccgggt acaatacccc catcctgcgc gccaccaaga aggggcagtt caacatcctg     2220

gccgaactga aaaagcagaa caagatcaag atctttgaga tcgagaag                  2268


<210> 66
<211> 2268
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 66
atgaccacaa agcaggtgaa gagcatcgtg ctgaaggtga agaacaccaa tgagtgccca       60

atcacaaagg acgtgatcaa cgagtacaag aagtactata atatctgttc cgagtggatc      120

aaggacaacc tgacctccat cacaatcggc gatatcgcct ctttcctgaa ggaggccacc      180

aataaggata ccatccccac atatatcaac atgggcctgt ccgaggagtg gaagtacaag      240

cctatctatc acctgttcac agaccgttac cacgagaagt ctgccaacaa tctgctgtac      300

gcctacttca aggagaagaa cctggactgc tataacggca atatcctgaa tctgtccgag      360

acctactatc ggagaaacgg ctacttcaag tctgtggtgg gcaattatcg gaccaagatc      420

agaacactga actacaagat caagaggaag aatgtggacg agaactctac aaatgaggat      480

atcgagctgc aggtcatgta tgagatcgcc aagcgcaagc tgaacatcaa gaaggactgg      540

gagaattaca tcagctatat cgagaacgtg gagaacatca atatcaagaa catcgatagg      600

tacaatctgc tgtataagca cttctgcgag aacgagagca ccatcaattg taagatggag      660

ctgctgtccg tggagcagct gaaggagttt ggcggctgcg tgatgaagca gcacatcaac      720

tctatgacaa tcaatatcca ggatttcaag atcgagaaca aggagaatag cctgggcttt      780

atcctgaacc tgcccctgaa caagaagaag taccagatcg agctgtgggg caaccggcag      840

atcaagaagg gcaacaagga caattacaag accctggtgg atttcatcaa cacatatggc      900

cagaacatca tctttaccat caagaacaat aagatctacg tggtgttctc ctatgagtgt      960

gagctgaagg agaaggagat caactttgac aagatcgtgg gcatcgatgt gaatttcaag     1020

cacgccctgt ttgtggcctc tgagagagac aagaacccac tgcaggataa caatcagctg     1080

aagggctaca tcaacctgta cggctatctg ctggagcaca atgagttcac cagcctgctg     1140

acaaaggagg agctggacat ctacaaggag atcgccaagg gcgtgacctt ctgccccctg     1200

gagtataacc tgctgtttac aaggatcgag aacaagggcg gcaagtccaa tgataaggag     1260

caggtgctga gcaagctgct gtactccctg cagatcaagc tgaagaacga gaataagatc     1320

caggagtaca tctacgtgag ctgcgtgaat aagctgcgcg ccaagtacgt gagctatttc     1380

atcctgaagg agaagtacta tgagaagcag aaggagtacg acatcgagat gggctttacc     1440

gacgatagca cagagtccaa ggagtctatg gataagaggc gcctggagtt cccttttcgg     1500

aacacccaga tcgccaatgg cttcctggag aagctgagca acgtgcagca ggacatcaat     1560

ggctgtctga agaacatcat caattacgcc tataaggtgt tcgagcagaa cggctttggc     1620

gtgatcgccc tggagaatct ggagaacagc aattttgaga agacccaggt gctgccaaca     1680

atcaagtccc tgctgcgtta ccacaagctg gagaaccaga atatcaacaa tatcaacgcc     1740

tctgacaagg tgaaggagta tatcgagaag gagtactatg agctgaccac aaatgagaac     1800

aatgagatcg tggatgccaa gtacaccaag aagggcatca tcaaggtgaa gaaggccaac     1860

ttctttaatc tgatgatgaa gtctctgcac ttcgccagca acaaggacga gtttatcctg     1920

ctgtccaaca atggcaagac ccagatcgcc ctggtgccca gcgagtacac atcccagatg     1980

gattctatcg agcactgcct gtatgtggac aagaacggca agaaggtgga taagaagaag     2040

gtgcggcaga agcaggagac ccacatcaac ggcctgaatg ccgacttcaa tgccgccaac     2100

aatatcaagt acatcatcga gaacgagaat ctgagaaagc tgttttgtgg caagctgaag     2160

gtgtccggct ataacacccc tatcctgcgt gccacaaaga agggccagtt caacatcctg     2220

gccgagctga agaagcagaa taagatcaag atctttgaga tcgagaag                  2268


