                         SEQUENCE LISTING

<110>  The Johns Hopkins University
 
<120>  ENGINEERED IMMUNE CELLS AND USES THEREOF

<130>  44807-0389WO1

<150>  63/160,338
<151>  2021-03-12

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  243
<212>  PRT
<213>  Artificial

<220>
<223>  Clone 13 scFv

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Ser Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Asn Leu Ser Gly Thr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Phe Ser Pro 
                165                 170                 175     


Tyr Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Gly Ser Ser 
    210                 215                 220                 


His Ser Ser Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  2
<211>  499
<212>  PRT
<213>  Artificial

<220>
<223>  A2-CAR (Clone BB7.2)

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr His Ile Gln Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Ile Tyr Phe Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
145                 150                 155                 160 


Ala Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Val Ser Ile Ser 
                165                 170                 175     


Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu 
            180                 185                 190         


Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
225                 230                 235                 240 


Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Thr Gly Leu Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Phe Trp 
305                 310                 315                 320 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                325                 330                 335     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
            340                 345                 350         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        355                 360                 365             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    370                 375                 380                 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  3
<211>  495
<212>  PRT
<213>  Artificial

<220>
<223>  `A3-CAR (Clone 13)

<400>  3

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
            100                 105                 110         


Tyr Thr Ser Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Gly Thr 
                165                 170                 175     


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ala Trp Phe Ser Pro Tyr Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ser Arg Gly Ser Ser His Ser Ser Val Ala Phe Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Gly Leu Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  4
<211>  440
<212>  PRT
<213>  Artificial

<220>
<223>  A2-iCAR (Clone BB7.2)

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr His Ile Gln Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Ile Tyr Phe Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
145                 150                 155                 160 


Ala Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Val Ser Ile Ser 
                165                 170                 175     


Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu 
            180                 185                 190         


Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
225                 230                 235                 240 


Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Thr Gly Leu Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Asn His Arg Cys Ser Arg Ala Ala Arg Gly Thr Ile 
            340                 345                 350         


Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val 
        355                 360                 365             


Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu 
    370                 375                 380                 


Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr 
385                 390                 395                 400 


Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg 
                405                 410                 415     


Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu 
            420                 425                 430         


Asp Gly His Cys Ser Trp Pro Leu 
        435                 440 


<210>  5
<211>  436
<212>  PRT
<213>  Artificial

<220>
<223>  A3-iCAR (Clone 13)

<400>  5

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
            100                 105                 110         


Tyr Thr Ser Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Gly Thr 
                165                 170                 175     


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ala Trp Phe Ser Pro Tyr Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ser Arg Gly Ser Ser His Ser Ser Val Ala Phe Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Gly Leu Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Asn His Arg Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg 
            340                 345                 350         


Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser 
        355                 360                 365             


Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu 
    370                 375                 380                 


Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val 
385                 390                 395                 400 


Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala 
                405                 410                 415     


Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys 
            420                 425                 430         


Ser Trp Pro Leu 
        435     


<210>  6
<211>  989
<212>  PRT
<213>  Artificial

<220>
<223>  B2M--A2-iCAR-2A-A3-CAR

<400>  6

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            20                  25                  30          


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        35                  40                  45              


Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    50                  55                  60                  


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
65                  70                  75                  80  


His Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
                85                  90                  95      


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
            100                 105                 110         


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
        115                 120                 125             


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
    130                 135                 140                 


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
145                 150                 155                 160 


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Pro Leu Ser Leu 
            180                 185                 190         


Pro Val Ser Leu Gly Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln 
        195                 200                 205             


Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln 
    210                 215                 220                 


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
225                 230                 235                 240 


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                245                 250                 255     


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            260                 265                 270         


Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr 
        275                 280                 285             


Lys Leu Glu Leu Lys Arg Thr Gly Leu Ser Thr Thr Thr Pro Ala Pro 
    290                 295                 300                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
305                 310                 315                 320 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                325                 330                 335     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            340                 345                 350         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
        355                 360                 365             


His Arg Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr 
    370                 375                 380                 


Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val 
385                 390                 395                 400 


Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro 
                405                 410                 415     


Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe 
            420                 425                 430         


Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp 
        435                 440                 445             


Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser 
    450                 455                 460                 


Trp Pro Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
465                 470                 475                 480 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
                485                 490                 495     


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
            500                 505                 510         


Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        515                 520                 525             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    530                 535                 540                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
545                 550                 555                 560 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                565                 570                 575     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            580                 585                 590         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr 
        595                 600                 605             


Ser Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Glu Val 
625                 630                 635                 640 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                645                 650                 655     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Gly Thr Tyr Met 
            660                 665                 670         


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp 
        675                 680                 685             


Phe Ser Pro Tyr Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly 
    690                 695                 700                 


Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln 
705                 710                 715                 720 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg 
                725                 730                 735     


Gly Ser Ser His Ser Ser Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            740                 745                 750         


Leu Val Thr Val Ser Ser Gly Leu Ser Thr Thr Thr Pro Ala Pro Arg 
        755                 760                 765             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    770                 775                 780                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
785                 790                 795                 800 


Leu Asp Phe Ala Cys Asp Ile Tyr Phe Trp Val Leu Val Val Val Gly 
                805                 810                 815     


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
            820                 825                 830         


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
        835                 840                 845             


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
    850                 855                 860                 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
865                 870                 875                 880 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                885                 890                 895     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            900                 905                 910         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
        915                 920                 925             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    930                 935                 940                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
945                 950                 955                 960 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                965                 970                 975     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            980                 985                 


<210>  7
<211>  522
<212>  PRT
<213>  Artificial

<220>
<223>  B2M--A3-CAR

<400>  7

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            20                  25                  30          


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        35                  40                  45              


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
    50                  55                  60                  


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
65                  70                  75                  80  


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                85                  90                  95      


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
            100                 105                 110         


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
        115                 120                 125             


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Ser Pro Ile 
    130                 135                 140                 


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Glu Val Gln Leu Val 
                165                 170                 175     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            180                 185                 190         


Cys Ala Ala Ser Gly Phe Asn Leu Ser Gly Thr Tyr Met His Trp Val 
        195                 200                 205             


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Phe Ser Pro 
    210                 215                 220                 


Tyr Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
225                 230                 235                 240 


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
                245                 250                 255     


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Gly Ser Ser 
            260                 265                 270         


His Ser Ser Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        275                 280                 285             


Val Ser Ser Gly Leu Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    290                 295                 300                 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
305                 310                 315                 320 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                325                 330                 335     


Ala Cys Asp Ile Tyr Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
            340                 345                 350         


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
        355                 360                 365             


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
    370                 375                 380                 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
385                 390                 395                 400 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
                405                 410                 415     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            420                 425                 430         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        435                 440                 445             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
    450                 455                 460                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
465                 470                 475                 480 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                485                 490                 495     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            500                 505                 510         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520         


<210>  8
<211>  885
<212>  PRT
<213>  Artificial

<220>
<223>  CD28H/TM - A2-ICdel-2A-A3-CAR

<400>  8

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            20                  25                  30          


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        35                  40                  45              


Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    50                  55                  60                  


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
65                  70                  75                  80  


His Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
                85                  90                  95      


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
            100                 105                 110         


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
        115                 120                 125             


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
    130                 135                 140                 


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
145                 150                 155                 160 


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Pro Leu Ser Leu 
            180                 185                 190         


Pro Val Ser Leu Gly Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln 
        195                 200                 205             


Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln 
    210                 215                 220                 


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
225                 230                 235                 240 


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                245                 250                 255     


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            260                 265                 270         


Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr 
        275                 280                 285             


Lys Leu Glu Leu Lys Arg Ala Ala Ala Pro Thr Thr Thr Pro Ala Pro 
    290                 295                 300                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
305                 310                 315                 320 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                325                 330                 335     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            340                 345                 350         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
        355                 360                 365             


His Arg Met His Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
    370                 375                 380                 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
385                 390                 395                 400 


Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
                405                 410                 415     


Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            420                 425                 430         


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        435                 440                 445             


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    450                 455                 460                 


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
465                 470                 475                 480 


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                485                 490                 495     


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            500                 505                 510         


Thr Ser Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        515                 520                 525             


Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Glu 
    530                 535                 540                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
545                 550                 555                 560 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Gly Thr Tyr 
                565                 570                 575     


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
            580                 585                 590         


Trp Phe Ser Pro Tyr Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val Lys 
        595                 600                 605             


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
    610                 615                 620                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
625                 630                 635                 640 


Arg Gly Ser Ser His Ser Ser Val Ala Phe Asp Tyr Trp Gly Gln Gly 
                645                 650                 655     


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Ile Glu Val Met Tyr Pro 
            660                 665                 670         


Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 
        675                 680                 685             


Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
    690                 695                 700                 


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
705                 710                 715                 720 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                725                 730                 735     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            740                 745                 750         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        755                 760                 765             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    770                 775                 780                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
785                 790                 795                 800 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                805                 810                 815     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            820                 825                 830         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        835                 840                 845             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    850                 855                 860                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
865                 870                 875                 880 


Ala Leu Pro Pro Arg 
                885 


<210>  9
<211>  982
<212>  PRT
<213>  Artificial

<220>
<223>  CD28H/TM - A2-iCAR-2A-A3-CAR

<400>  9

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            20                  25                  30          


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        35                  40                  45              


Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    50                  55                  60                  


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
65                  70                  75                  80  


His Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
                85                  90                  95      


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
            100                 105                 110         


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
        115                 120                 125             


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
    130                 135                 140                 


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
145                 150                 155                 160 


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Pro Leu Ser Leu 
            180                 185                 190         


Pro Val Ser Leu Gly Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln 
        195                 200                 205             


Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln 
    210                 215                 220                 


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
225                 230                 235                 240 


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                245                 250                 255     


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            260                 265                 270         


Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr 
        275                 280                 285             


Lys Leu Glu Leu Lys Arg Ala Ala Ala Pro Thr Thr Thr Pro Ala Pro 
    290                 295                 300                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
305                 310                 315                 320 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                325                 330                 335     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            340                 345                 350         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
        355                 360                 365             


His Arg Met His Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg 
    370                 375                 380                 


Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe 
385                 390                 395                 400 


Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro 
                405                 410                 415     


Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile 
            420                 425                 430         


Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser 
        435                 440                 445             


Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His 
    450                 455                 460                 


Cys Ser Trp Pro Leu Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn 
465                 470                 475                 480 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                485                 490                 495     


Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
            500                 505                 510         


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
        515                 520                 525             


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
    530                 535                 540                 


Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
545                 550                 555                 560 


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro 
                565                 570                 575     


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
            580                 585                 590         


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
        595                 600                 605             


Tyr Thr Ser Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
    610                 615                 620                 


Arg Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser 
625                 630                 635                 640 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                645                 650                 655     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Gly Thr 
            660                 665                 670         


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        675                 680                 685             


Ala Trp Phe Ser Pro Tyr Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val 
    690                 695                 700                 


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
705                 710                 715                 720 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                725                 730                 735     


Ser Arg Gly Ser Ser His Ser Ser Val Ala Phe Asp Tyr Trp Gly Gln 
            740                 745                 750         


Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Ile Glu Val Met Tyr 
        755                 760                 765             


Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
    770                 775                 780                 


Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
785                 790                 795                 800 


Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
                805                 810                 815     


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
            820                 825                 830         


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
        835                 840                 845             


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
    850                 855                 860                 


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
865                 870                 875                 880 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                885                 890                 895     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            900                 905                 910         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        915                 920                 925             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    930                 935                 940                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
945                 950                 955                 960 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                965                 970                 975     


Gln Ala Leu Pro Pro Arg 
            980         


<210>  10
<211>  1452
<212>  PRT
<213>  Artificial

<220>
<223>  CD28H/TM - 2xA2-iCAR-2A-A3-CAR

<400>  10

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            20                  25                  30          


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        35                  40                  45              


Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    50                  55                  60                  


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
65                  70                  75                  80  


His Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
                85                  90                  95      


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
            100                 105                 110         


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
        115                 120                 125             


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
    130                 135                 140                 


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
145                 150                 155                 160 


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Pro Leu Ser Leu 
            180                 185                 190         


Pro Val Ser Leu Gly Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln 
        195                 200                 205             


Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln 
    210                 215                 220                 


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
225                 230                 235                 240 


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                245                 250                 255     


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            260                 265                 270         


Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr 
        275                 280                 285             


Lys Leu Glu Leu Lys Arg Ala Ala Ala Pro Thr Thr Thr Pro Ala Pro 
    290                 295                 300                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
305                 310                 315                 320 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                325                 330                 335     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            340                 345                 350         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
        355                 360                 365             


His Arg Met His Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg 
    370                 375                 380                 


Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe 
385                 390                 395                 400 


Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro 
                405                 410                 415     


Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile 
            420                 425                 430         


Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser 
        435                 440                 445             


Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His 
    450                 455                 460                 


Cys Ser Trp Pro Leu Arg Ala Lys Arg Ser Gly Ser Gly Gln Cys Thr 
465                 470                 475                 480 


Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
                485                 490                 495     


Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
            500                 505                 510         


Leu His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu 
        515                 520                 525             


Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
    530                 535                 540                 


Tyr Thr Phe Thr Ser Tyr His Ile Gln Trp Val Lys Gln Arg Pro Gly 
545                 550                 555                 560 


Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr 
                565                 570                 575     


Gln Tyr Asn Glu Lys Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys 
            580                 585                 590         


Ser Ser Ser Thr Ala Tyr Met Leu Leu Ser Ser Leu Thr Ser Glu Asp 
        595                 600                 605             


Ser Ala Ile Tyr Phe Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp 
    610                 615                 620                 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
                645                 650                 655     


Gln Ala Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Val Ser Ile 
            660                 665                 670         


Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
        675                 680                 685             


Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
    690                 695                 700                 


Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
705                 710                 715                 720 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
                725                 730                 735     


Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg 
            740                 745                 750         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Pro 
        755                 760                 765             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    770                 775                 780                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
785                 790                 795                 800 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
                805                 810                 815     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            820                 825                 830         


Ile Thr Leu Tyr Cys Asn His Arg Met His Cys Ser Arg Ala Ala Arg 
        835                 840                 845             


Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro 
    850                 855                 860                 


Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln 
865                 870                 875                 880 


Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln 
                885                 890                 895     


Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser 
            900                 905                 910         


Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu 
        915                 920                 925             


Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Arg Ala Lys Arg Ser 
    930                 935                 940                 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
945                 950                 955                 960 


Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu 
                965                 970                 975     


Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile Gln Met Thr 
            980                 985                 990         


Gln Ser Pro Ser Ser Leu Ser Ala  Ser Val Gly Asp Arg  Val Thr Ile 
        995                 1000                 1005             


Thr Cys  Arg Ala Ser Gln Asp  Val Asn Thr Ala Val  Ala Trp Tyr 
    1010                 1015                 1020             


Gln Gln  Lys Pro Gly Lys Ala  Pro Lys Leu Leu Ile  Tyr Ser Ala 
    1025                 1030                 1035             


Ser Phe  Leu Tyr Ser Gly Val  Pro Ser Arg Phe Ser  Gly Ser Arg 
    1040                 1045                 1050             


Ser Gly  Thr Asp Phe Thr Leu  Thr Ile Ser Ser Leu  Gln Pro Glu 
    1055                 1060                 1065             


Asp Phe  Ala Thr Tyr Tyr Cys  Gln Gln Ser Tyr Thr  Ser Pro Ile 
    1070                 1075                 1080             


Thr Phe  Gly Gln Gly Thr Lys  Val Glu Ile Lys Arg  Thr Gly Gly 
    1085                 1090                 1095             


Gly Ser  Gly Gly Gly Gly Ser  Gly Gly Gly Ala Ser  Glu Val Gln 
    1100                 1105                 1110             


Leu Val  Glu Ser Gly Gly Gly  Leu Val Gln Pro Gly  Gly Ser Leu 
    1115                 1120                 1125             


Arg Leu  Ser Cys Ala Ala Ser  Gly Phe Asn Leu Ser  Gly Thr Tyr 
    1130                 1135                 1140             


Met His  Trp Val Arg Gln Ala  Pro Gly Lys Gly Leu  Glu Trp Val 
    1145                 1150                 1155             


Ala Trp  Phe Ser Pro Tyr Ser  Ser Tyr Thr Asn Tyr  Ala Asp Ser 
    1160                 1165                 1170             


Val Lys  Gly Arg Phe Thr Ile  Ser Ala Asp Thr Ser  Lys Asn Thr 
    1175                 1180                 1185             


Ala Tyr  Leu Gln Met Asn Ser  Leu Arg Ala Glu Asp  Thr Ala Val 
    1190                 1195                 1200             


Tyr Tyr  Cys Ser Arg Gly Ser  Ser His Ser Ser Val  Ala Phe Asp 
    1205                 1210                 1215             


Tyr Trp  Gly Gln Gly Thr Leu  Val Thr Val Ser Ser  Ala Ala Ala 
    1220                 1225                 1230             


Ile Glu  Val Met Tyr Pro Pro  Pro Tyr Leu Asp Asn  Glu Lys Ser 
    1235                 1240                 1245             


Asn Gly  Thr Ile Ile His Val  Lys Gly Lys His Leu  Cys Pro Ser 
    1250                 1255                 1260             


Pro Leu  Phe Pro Gly Pro Ser  Lys Pro Phe Trp Val  Leu Val Val 
    1265                 1270                 1275             


Val Gly  Gly Val Leu Ala Cys  Tyr Ser Leu Leu Val  Thr Val Ala 
    1280                 1285                 1290             


Phe Ile  Ile Phe Trp Val Arg  Ser Lys Arg Ser Arg  Leu Leu His 
    1295                 1300                 1305             


Ser Asp  Tyr Met Asn Met Thr  Pro Arg Arg Pro Gly  Pro Thr Arg 
    1310                 1315                 1320             


Lys His  Tyr Gln Pro Tyr Ala  Pro Pro Arg Asp Phe  Ala Ala Tyr 
    1325                 1330                 1335             


Arg Ser  Arg Val Lys Phe Ser  Arg Ser Ala Asp Ala  Pro Ala Tyr 
    1340                 1345                 1350             


Gln Gln  Gly Gln Asn Gln Leu  Tyr Asn Glu Leu Asn  Leu Gly Arg 
    1355                 1360                 1365             


Arg Glu  Glu Tyr Asp Val Leu  Asp Lys Arg Arg Gly  Arg Asp Pro 
    1370                 1375                 1380             


Glu Met  Gly Gly Lys Pro Arg  Arg Lys Asn Pro Gln  Glu Gly Leu 
    1385                 1390                 1395             


Tyr Asn  Glu Leu Gln Lys Asp  Lys Met Ala Glu Ala  Tyr Ser Glu 
    1400                 1405                 1410             


Ile Gly  Met Lys Gly Glu Arg  Arg Arg Gly Lys Gly  His Asp Gly 
    1415                 1420                 1425             


Leu Tyr  Gln Gly Leu Ser Thr  Ala Thr Lys Asp Thr  Tyr Asp Ala 
    1430                 1435                 1440             


Leu His  Met Gln Ala Leu Pro  Pro Arg 
    1445                 1450         


<210>  11
<211>  893
<212>  PRT
<213>  Artificial

<220>
<223>  CD8H/TM - A3-CAR-2A-A2-ICdel

<400>  11

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            20                  25                  30          


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        35                  40                  45              


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
    50                  55                  60                  


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
65                  70                  75                  80  


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                85                  90                  95      


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
            100                 105                 110         


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
        115                 120                 125             


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Ser Pro Ile 
    130                 135                 140                 


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Glu Val Gln Leu Val 
                165                 170                 175     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            180                 185                 190         


Cys Ala Ala Ser Gly Phe Asn Leu Ser Gly Thr Tyr Met His Trp Val 
        195                 200                 205             


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Phe Ser Pro 
    210                 215                 220                 


Tyr Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
225                 230                 235                 240 


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
                245                 250                 255     


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Gly Ser Ser 
            260                 265                 270         


His Ser Ser Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        275                 280                 285             


Val Ser Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    290                 295                 300                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
305                 310                 315                 320 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                325                 330                 335     


Cys Asp Ile Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            340                 345                 350         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        355                 360                 365             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    370                 375                 380                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
385                 390                 395                 400 


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
                405                 410                 415     


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
            420                 425                 430         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
        435                 440                 445             


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
    450                 455                 460                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
465                 470                 475                 480 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                485                 490                 495     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            500                 505                 510         


Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg Ser Gly Ser Gly Ala 
        515                 520                 525             


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
    530                 535                 540                 


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
545                 550                 555                 560 


Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro 
                565                 570                 575     


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser 
            580                 585                 590         


Gly Tyr Thr Phe Thr Ser Tyr His Ile Gln Trp Val Lys Gln Arg Pro 
        595                 600                 605             


Gly Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser 
    610                 615                 620                 


Thr Gln Tyr Asn Glu Lys Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp 
625                 630                 635                 640 


Lys Ser Ser Ser Thr Ala Tyr Met Leu Leu Ser Ser Leu Thr Ser Glu 
                645                 650                 655     


Asp Ser Ala Ile Tyr Phe Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met 
            660                 665                 670         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
    690                 695                 700                 


Thr Gln Ala Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Val Ser 
705                 710                 715                 720 


Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr 
                725                 730                 735     


Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
            740                 745                 750         


Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
        755                 760                 765             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
    770                 775                 780                 


Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro 
785                 790                 795                 800 


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Met Asp Pro Ala 
                805                 810                 815     


Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro Thr 
            820                 825                 830         


Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly Ser 
        835                 840                 845             


Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
    850                 855                 860                 


Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu Ile Ile Thr 
865                 870                 875                 880 


Leu Ile Cys Tyr His Arg Ser Arg Lys Arg Val Cys Lys 
                885                 890             


<210>  12
<211>  1178
<212>  PRT
<213>  Artificial

<220>
<223>  CD8H/TM - A3-CAR-2A-A2-SHP1

<400>  12

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            20                  25                  30          


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        35                  40                  45              


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
    50                  55                  60                  


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
65                  70                  75                  80  


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                85                  90                  95      


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
            100                 105                 110         


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
        115                 120                 125             


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Ser Pro Ile 
    130                 135                 140                 


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Glu Val Gln Leu Val 
                165                 170                 175     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            180                 185                 190         


Cys Ala Ala Ser Gly Phe Asn Leu Ser Gly Thr Tyr Met His Trp Val 
        195                 200                 205             


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Phe Ser Pro 
    210                 215                 220                 


Tyr Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
225                 230                 235                 240 


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
                245                 250                 255     


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Gly Ser Ser 
            260                 265                 270         


His Ser Ser Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        275                 280                 285             


Val Ser Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    290                 295                 300                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
305                 310                 315                 320 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                325                 330                 335     


Cys Asp Ile Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            340                 345                 350         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        355                 360                 365             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    370                 375                 380                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
385                 390                 395                 400 


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
                405                 410                 415     


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
            420                 425                 430         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
        435                 440                 445             


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
    450                 455                 460                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
465                 470                 475                 480 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                485                 490                 495     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            500                 505                 510         


Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg Ser Gly Ser Gly Ala 
        515                 520                 525             


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
    530                 535                 540                 


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
545                 550                 555                 560 


Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro 
                565                 570                 575     


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser 
            580                 585                 590         


Gly Tyr Thr Phe Thr Ser Tyr His Ile Gln Trp Val Lys Gln Arg Pro 
        595                 600                 605             


Gly Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser 
    610                 615                 620                 


Thr Gln Tyr Asn Glu Lys Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp 
625                 630                 635                 640 


Lys Ser Ser Ser Thr Ala Tyr Met Leu Leu Ser Ser Leu Thr Ser Glu 
                645                 650                 655     


Asp Ser Ala Ile Tyr Phe Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met 
            660                 665                 670         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
    690                 695                 700                 


Thr Gln Ala Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Val Ser 
705                 710                 715                 720 


Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr 
                725                 730                 735     


Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
            740                 745                 750         


Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
        755                 760                 765             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
    770                 775                 780                 


Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro 
785                 790                 795                 800 


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Met Asp Pro Ala 
                805                 810                 815     


Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro Thr 
            820                 825                 830         


Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly Ser 
        835                 840                 845             


Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
    850                 855                 860                 


Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu Ile Ile Thr 
865                 870                 875                 880 


Leu Ile Cys Tyr His Arg Ser Arg Lys Arg Val Cys Lys Ser Gly Gly 
                885                 890                 895     


Gly Ser Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val Lys 
            900                 905                 910         


Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly Lys 
        915                 920                 925             


Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile Leu 
    930                 935                 940                 


Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala Asn 
945                 950                 955                 960 


Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr Tyr 
                965                 970                 975     


Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp Gln 
            980                 985                 990         


Met Ala Trp Gln Glu Asn Ser Arg  Val Ile Val Met Thr  Thr Arg Glu 
        995                 1000                 1005             


Val Glu  Lys Gly Arg Asn Lys  Cys Val Pro Tyr Trp  Pro Glu Val 
    1010                 1015                 1020             


Gly Met  Gln Arg Ala Tyr Gly  Pro Tyr Ser Val Thr  Asn Cys Gly 
    1025                 1030                 1035             


Glu His  Asp Thr Thr Glu Tyr  Lys Leu Arg Thr Leu  Gln Val Ser 
    1040                 1045                 1050             


Pro Leu  Asp Asn Gly Asp Leu  Ile Arg Glu Ile Trp  His Tyr Gln 
    1055                 1060                 1065             


Tyr Leu  Ser Trp Pro Asp His  Gly Val Pro Ser Glu  Pro Gly Gly 
    1070                 1075                 1080             


Val Leu  Ser Phe Leu Asp Gln  Ile Asn Gln Arg Gln  Glu Ser Leu 
    1085                 1090                 1095             


Pro His  Ala Gly Pro Ile Ile  Val His Cys Ser Ala  Gly Ile Gly 
    1100                 1105                 1110             


Arg Thr  Gly Thr Ile Ile Val  Ile Asp Met Leu Met  Glu Asn Ile 
    1115                 1120                 1125             


Ser Thr  Lys Gly Leu Asp Cys  Asp Ile Asp Ile Gln  Lys Thr Ile 
    1130                 1135                 1140             


Gln Met  Val Arg Ala Gln Arg  Ser Gly Met Val Gln  Thr Glu Ala 
    1145                 1150                 1155             


Gln Tyr  Lys Phe Ile Tyr Val  Ala Ile Ala Gln Phe  Ile Glu Thr 
    1160                 1165                 1170             


Thr Lys  Lys Lys Leu 
    1175             


<210>  13
<211>  1426
<212>  PRT
<213>  Artificial

<220>
<223>  CD8H/TM - A3-CAR-2A-A2-CD148

<400>  13

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            20                  25                  30          


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        35                  40                  45              


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
    50                  55                  60                  


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
65                  70                  75                  80  


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                85                  90                  95      


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
            100                 105                 110         


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
        115                 120                 125             


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Ser Pro Ile 
    130                 135                 140                 


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Glu Val Gln Leu Val 
                165                 170                 175     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            180                 185                 190         


Cys Ala Ala Ser Gly Phe Asn Leu Ser Gly Thr Tyr Met His Trp Val 
        195                 200                 205             


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Phe Ser Pro 
    210                 215                 220                 


Tyr Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
225                 230                 235                 240 


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
                245                 250                 255     


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Gly Ser Ser 
            260                 265                 270         


His Ser Ser Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        275                 280                 285             


Val Ser Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    290                 295                 300                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
305                 310                 315                 320 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                325                 330                 335     


Cys Asp Ile Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            340                 345                 350         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        355                 360                 365             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    370                 375                 380                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
385                 390                 395                 400 


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
                405                 410                 415     


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
            420                 425                 430         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
        435                 440                 445             


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
    450                 455                 460                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
465                 470                 475                 480 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                485                 490                 495     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            500                 505                 510         


Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg Ser Gly Ser Gly Ala 
        515                 520                 525             


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
    530                 535                 540                 


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
545                 550                 555                 560 


Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro 
                565                 570                 575     


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser 
            580                 585                 590         


Gly Tyr Thr Phe Thr Ser Tyr His Ile Gln Trp Val Lys Gln Arg Pro 
        595                 600                 605             


Gly Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser 
    610                 615                 620                 


Thr Gln Tyr Asn Glu Lys Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp 
625                 630                 635                 640 


Lys Ser Ser Ser Thr Ala Tyr Met Leu Leu Ser Ser Leu Thr Ser Glu 
                645                 650                 655     


Asp Ser Ala Ile Tyr Phe Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met 
            660                 665                 670         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
    690                 695                 700                 


Thr Gln Ala Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Val Ser 
705                 710                 715                 720 


Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr 
                725                 730                 735     


Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
            740                 745                 750         


Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
        755                 760                 765             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
    770                 775                 780                 


Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro 
785                 790                 795                 800 


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Met Asp Pro Ala 
                805                 810                 815     


Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro Thr 
            820                 825                 830         


Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly Ser 
        835                 840                 845             


Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Leu Ile Gly Val 
    850                 855                 860                 


Ser Val Val Phe Leu Phe Cys Leu Leu Leu Leu Val Leu Phe Cys Leu 
865                 870                 875                 880 


His Arg Gln Asn Gln Ile Lys Gln Gly Pro Pro Arg Ser Lys Asp Glu 
                885                 890                 895     


Glu Gln Lys Pro Gln Gln Arg Pro Asp Leu Ala Val Asp Val Leu Glu 
            900                 905                 910         


Arg Thr Ala Asp Lys Ala Thr Val Asn Gly Leu Pro Glu Lys Asp Arg 
        915                 920                 925             


Glu Thr Asp Thr Ser Ala Leu Ala Ala Gly Ser Ser Gln Glu Val Thr 
    930                 935                 940                 


Tyr Ala Gln Leu Asp His Trp Ala Leu Thr Gln Arg Thr Ala Arg Ala 
945                 950                 955                 960 


Val Ser Pro Gln Ser Thr Lys Pro Met Ala Glu Ser Ile Thr Tyr Ala 
                965                 970                 975     


Ala Val Ala Arg His Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys 
            980                 985                 990         


Gly Asp Val Glu Glu Asn Pro Gly  Pro Trp Tyr His Gly  His Met Ser 
        995                 1000                 1005             


Gly Gly  Gln Ala Glu Thr Leu  Leu Gln Ala Lys Gly  Glu Pro Trp 
    1010                 1015                 1020             


Thr Phe  Leu Val Arg Glu Ser  Leu Ser Gln Pro Gly  Asp Phe Val 
    1025                 1030                 1035             


Leu Ser  Val Leu Ser Asp Gln  Pro Lys Ala Gly Pro  Gly Ser Pro 
    1040                 1045                 1050             


Leu Arg  Val Thr His Ile Lys  Val Met Cys Glu Gly  Gly Arg Tyr 
    1055                 1060                 1065             


Thr Val  Gly Gly Leu Glu Thr  Phe Asp Ser Leu Thr  Asp Leu Val 
    1070                 1075                 1080             


Glu His  Phe Lys Lys Thr Gly  Ile Glu Glu Ala Ser  Gly Ala Phe 
    1085                 1090                 1095             


Val Tyr  Leu Arg Gln Pro Tyr  Ser Gly Gly Gly Gly  Ser Phe Glu 
    1100                 1105                 1110             


Ala Tyr  Phe Lys Lys Gln Gln  Ala Asp Ser Asn Cys  Gly Phe Ala 
    1115                 1120                 1125             


Glu Glu  Tyr Glu Asp Leu Lys  Leu Val Gly Ile Ser  Gln Pro Lys 
    1130                 1135                 1140             


Tyr Ala  Ala Glu Leu Ala Glu  Asn Arg Gly Lys Asn  Arg Tyr Asn 
    1145                 1150                 1155             


Asn Val  Leu Pro Tyr Asp Ile  Ser Arg Val Lys Leu  Ser Val Gln 
    1160                 1165                 1170             


Thr His  Ser Thr Asp Asp Tyr  Ile Asn Ala Asn Tyr  Met Pro Gly 
    1175                 1180                 1185             


Tyr His  Ser Lys Lys Asp Phe  Ile Ala Thr Gln Gly  Pro Leu Pro 
    1190                 1195                 1200             


Asn Thr  Leu Lys Asp Phe Trp  Arg Met Val Trp Glu  Lys Asn Val 
    1205                 1210                 1215             


Tyr Ala  Ile Ile Met Leu Thr  Lys Cys Val Glu Gln  Gly Arg Thr 
    1220                 1225                 1230             


Lys Cys  Glu Glu Tyr Trp Pro  Ser Lys Gln Ala Gln  Asp Tyr Gly 
    1235                 1240                 1245             


Asp Ile  Thr Val Ala Met Thr  Ser Glu Ile Val Leu  Pro Glu Trp 
    1250                 1255                 1260             


Thr Ile  Arg Asp Phe Thr Val  Lys Asn Ile Gln Thr  Ser Glu Ser 
    1265                 1270                 1275             


His Pro  Leu Arg Gln Phe His  Phe Thr Ser Trp Pro  Asp His Gly 
    1280                 1285                 1290             


Val Pro  Asp Thr Thr Asp Leu  Leu Ile Asn Phe Arg  Tyr Leu Val 
    1295                 1300                 1305             


Arg Asp  Tyr Met Lys Gln Ser  Pro Pro Glu Ser Pro  Ile Leu Val 
    1310                 1315                 1320             


His Cys  Ser Ala Gly Val Gly  Arg Thr Gly Thr Phe  Ile Ala Ile 
    1325                 1330                 1335             


Asp Arg  Leu Ile Tyr Gln Ile  Glu Asn Glu Asn Thr  Val Asp Val 
    1340                 1345                 1350             


Tyr Gly  Ile Val Tyr Asp Leu  Arg Met His Arg Pro  Leu Met Val 
    1355                 1360                 1365             


Gln Thr  Glu Asp Gln Tyr Val  Phe Leu Asn Gln Cys  Val Leu Asp 
    1370                 1375                 1380             


Ile Val  Arg Ser Gln Lys Asp  Ser Lys Val Asp Leu  Ile Tyr Gln 
    1385                 1390                 1395             


Asn Thr  Thr Ala Met Thr Ile  Tyr Glu Asn Leu Ala  Pro Val Thr 
    1400                 1405                 1410             


Thr Phe  Gly Lys Thr Asn Gly  Tyr Ile Ala Ser Gly  Ser 
    1415                 1420                 1425     


